CN101516437A

CN101516437A - Implantable multi-electrode device

Info

Publication number: CN101516437A
Application number: CNA2007800350821A
Authority: CN
Inventors: M·默茨; Y·V·波诺马雷夫; R·H·W·皮南伯格
Original assignee: Koninklijke Philips Electronics NV
Current assignee: Sapiens Steering Brain Stimulation BV
Priority date: 2006-09-22
Filing date: 2007-09-18
Publication date: 2009-08-26
Also published as: WO2008035285A3; JP2010504128A; US8798737B2; US20100076536A1; EP2066396B1; US20140309548A1; EP2066396A2; RU2009115195A; US9020607B2; WO2008035285A2

Abstract

The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340...348) radiating from the assembly block (320), each of the plurality of leads (340...348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.

Description

Implantable multi-electrode device

Technical field

The present invention relates generally to electrode assembly, relate more particularly to implantable multi-electrode device, and the device that is used for its sealing and implantation.

Background technology

Many sacred diseases and condition of illness comprise in their symptom and trembling.Usually, utilizing Drug therapy only is partly can treat above-mentioned trembling.In other cases, along with the development of disease or condition of illness, the influence of Drug therapy reduces.In some cases, such as, serious Parkinson's disease, Drug therapy is invalid to controlling above-mentioned trembling.

Be the brain operation at present, in described brain operation, cause and form infringement in the brain zone of trembling thinking having the available Therapeutic Method of patient that drug resistance trembles.Yet, provide some to alleviate the above-mentioned operation of tremor symptoms though shown, there is more shortcoming in the irreversibility of above-mentioned Therapeutic Method.For example, if determine the unexpected damage that operation does not alleviate tremor symptoms and/or causes normal brain activity to be moved, patient does not obtain medical treatment.

Another Therapeutic Method that trembles for drug resistance comprises that electricity irritation causes the brain zone of tremor symptoms.These zones comprise subthalamic nuclei (STN), the ventral intermediate nucleus (VIM) of internal part of globus pallidus (GPi) and thalamus.For example, with reference to figure 1, individual 100 brain 110 target areas 112 are via one or more electrode 122 electricity irritation of being carried by lead 120, and described lead 120 is implanted in the brain 110 by surgical operation.Therefore, above-mentioned Therapeutic Method is commonly called dark brain stimulation art (DBS).Electric pulse typically uses the pacemaker-like neurostimulator 130 of implanting individual thoracic cavity to supply with and gives institute's implant electrode 122, and described electrode 122 is connected with the holding wire 128 of described nerve stimulator 130 below individual's skin.

Though DBS normally reversible (that is, electrode can and/or be reorientated with exenterate) provides change seldom at present aspect the brain volume of the electrode that uses around the irriate electrode.That is, the volume that is stimulated by known electrodes comprises the common cylindrical volume that directly centers on electrode.Fig. 2 shows the simplification view of the known lead 220 that three electrodes 222,224,226 are installed.Simultaneously, electrode 222,224 and 226 can stimulate the brain volume 240 adjacent with lead 220.As finding out among Fig. 2, volume 240 is columniform basically.Be positioned in brain target area 212 under the situation of volume 240 outsides, be difficult to or for example can not use the known electrodes of electrode shown in Fig. 2 to come stimulation target 212.Increase the electrical signal amplitude that is applied on the electrode and will increase volume 240, but still can not arrive target area 212, remove nontarget area 212 very near lead 220.In addition, the electrical signal amplitude size that may be increased to by the tissue injury adjacent with lead 220 begin limit.

On this degree, need to have the method and apparatus that is used for the treatment of individual with tremor symptoms, described method and apparatus does not have shortcoming well known in the prior art.

Summary of the invention

The invention provides a kind of implantable multi-electrode device and associated method and equipment.In one embodiment, the present invention includes implantable device, it comprises: building-blocks; And a plurality of leads of certainly dispersing from assembly, each in a plurality of leads contains at least one electrode, so that distribution of electrodes is in three dimensions inside, wherein, building-blocks comprises barb, is used for building-blocks is fastened to the organization internal of being implanted.

A first aspect of the present invention provides a kind of method that is used for electricity irritation is delivered to individual's nervous tissue, and method comprises: implantable stimulation thing device in individual's nervous tissue, and it comprises: building-blocks; And a plurality of leads that stretch out from building-blocks, each in a plurality of leads contains at least one electrode, so that distribution of electrodes is in the target volume of nervous tissue; And use at least one electrode to increase the electricity irritation of nervous tissue.

A second aspect of the present invention provides a kind of implantable device, and it comprises: building-blocks; And a plurality of leads of dispersing from building-blocks, each in a plurality of leads contains at least one electrode, so that distribution of electrodes is in three dimensions inside.

A third aspect of the present invention provides a kind of system that is used to implant implantable device, and system comprises: implantable device, and it comprises: building-blocks; And a plurality of leads of dispersing from building-blocks, each in a plurality of leads contains at least one electrode, so that distribution of electrodes is in three dimensions inside; And the equipment that is used to implant implantable device, it comprises: outer tube; Interior pipe; And the mating feature on the interior tube-surface that adapts with the lip-deep feature of implantable device, wherein, the internal diameter of the outer tube external diameter with interior pipe at least is the same big, so that implantable device can pass through outer tube through interior pipe.

A fourth aspect of the present invention provides a kind of equipment that is used to implant implantable device, and it comprises: outer tube; Interior pipe; And the mating feature on the interior tube-surface that adapts with the lip-deep feature of implantable device, wherein, the internal diameter of the outer tube external diameter with interior pipe at least is the same big, so that implantable device can pass through outer tube through interior pipe.

A fifth aspect of the present invention provides a kind of method that is used to protect implantable device, and method comprises: sealer is added on the surface of at least a portion implantable device.

Diagram of the present invention aspect is designed for and solves problem described herein and other problem that does not have discussion, and these problems are revealable to those skilled in the art.

Description of drawings

The following detailed description of different aspect will be easier to understand these and other features of the present invention together with the accompanying drawing of describing different embodiments of the invention according to the present invention, wherein:

Fig. 1 shows known dark brain stimulation art (DBS) device.

Fig. 2 shows the detailed view of Fig. 1 device.

Fig. 3 A shows according to graphic display unit of the present invention.

Fig. 3 B-C shows the part detailed view of Fig. 3 A device.

Fig. 4 shows according to illustrative encapsulated device of the present invention.

Fig. 5 A-C shows according to the consecutive steps in the sealer biodegradation of the present invention.

Fig. 6 A-C shows the general and detailed view according to the device of the present invention and the equipment of implantation.

Fig. 7 A-C shows another embodiment according to implantation equipment of the present invention and device.

Fig. 8 A-E shows the consecutive steps of implantation equipment implantation used according to the invention according to device of the present invention.

It is pointed out that accompanying drawing of the present invention is not proportional.Therefore accompanying drawing is intended to only describe typical aspect of the present invention, and should not be considered as and limit the scope of the invention, in the accompanying drawings, and identical digitized representation components identical between accompanying drawing.

The specific embodiment

As shown in above, the invention provides a kind of implantable multi-electrode device.Fig. 3 A-C shows the common and detailed view according to graphic display unit of the present invention.In Fig. 3 A, device 300 comprises building-blocks 320, stretches out one or more lead-in wire 328 and a plurality of flexible wire 340,342,344,346,348 from described building-blocks 320, and a plurality of arrangement of conductors are in three dimensions.Lead 340,342,344,346,348 can have than known electrodes device (see, for example, Fig. 1-2) littler diameter.Preferably, each lead 340,342,344,346,348 has the diameter littler than about 2mm, than the littler height of about 40mm, and enough hard, in implantation process, to thrust cerebral tissue.

Building-blocks 320 can have many forms, only is exemplifying described in Fig. 3 A.For example, assembly is determined and 320 can be comprised the pipe that a plurality of leads pass through.Replacedly, in a preferred embodiment, building-blocks 320 comprises from 328 to one or more lead 340...348 electronics duplex circuits that operationally distribute and stimulate that go between.In the above-described embodiments, can reduce lead-in wire 328 quantity, because they need only feeding assembly piece 320, rather than each of a plurality of lead 340...348.This provides many advantages, comprises owing to littler and/or more flexible implantation and the mechanical force that has reduced to be delivered to from skull device 300 of being more prone to of lead-in wire.In the above-described embodiments, the electronics duplex circuit can use for example other lead-in wire or radio frequency telemetry link to control.

By use a plurality of littler leads in the distributed in three dimensions of " fan out " more, the volume of target area 312 can be than using known devices more accurately to mate.That is, though a plurality of littler lead of the present invention can transmit and the approximately uniform peak power of known single-lead devices, the more accurate placement of a plurality of leads allows to use lower power.In addition, each lead can comprise one or more electrode.For example, as shown in Fig. 3 B, lead 342 comprises the single electrode 342A adjacent with its far-end.Otherwise Fig. 3 C shows the detailed view that comprises along the lead 346 of three electrode 346A-C of its distribution of lengths.Though, be described as transmitting stimulus signal up to now, need recognize that one or more electrode can replacedly be used for measuring and/or write down the level of nerve stimulation in the zone of implant electrode.

As noted before, because some electrode of the present invention is more near the target area, so stimulation amplitude (being used to obtain identical clinical effectiveness) is than being used for the littler of known electrodes device.This provides many advantages.At first, use the stimulus signal that has more by a small margin to reduce the danger of the tissue injury adjacent with electrode.The second, the combination of more accurately placing than small amplitude signal and each electrode has reduced the side effect that is caused by nontarget area stimulation in the brain.The 3rd, use stimulation more by a small margin to prolong the life-span of battery powered pulse generator (for example, the pacemaker-like neurostimulator among Fig. 1 130).

Device 300 can be supplied with according to the pre-lead of arranging of length, quantity and orientation, with coupling known target zone (for example, subthalamic nuclei (STN), the ventral intermediate nucleus (VIM) of internal part of globus pallidus (GPi) and thalamus).Replacedly, the layout of lead can according to use image device (for example, NMR (Nuclear Magnetic Resonance)-imaging (MRI) device, computerization x-ray tomography scanning (CT) device, or the like) target area determined customizes.Similarly, if determine that only a part of target area 312 needs to stimulate (for example, being the reason of tremor symptoms) after implantation, only lead 340,342, and the electrode of 344,346,348 subclass can be triggered.As described above, this can realize by using the building-blocks that for example contains the electronics duplex circuit.

Though the electricity irritation of brain target area may itself be enough to reduce or prevent individual's tremor symptoms,, in some cases, also can expect to increase one or more anti-Drug therapy of trembling of individual.In these cases, the dosage of the anti-Drug therapy of trembling is preferably lower than the dosage of drug effect when the stimulation of brain target area does not take place simultaneously.

As shown in Fig. 3 A, building-blocks 320 can at random comprise one or more barb 350,352, is used for building-blocks 320 is fastened to individual's cerebral tissue inside.In one embodiment, in a single day one or more barb can be suitable for folding in implantation process and lean on or be included in building-blocks 320 inside, and installs 300 in position, outstanding from building-blocks 32.In another embodiment, one or more barb 352 can be retractable, so that can easily remove implanting device 300.Building-blocks 320 preferably includes recess or similar characteristics, is used for angular orientation and/or rotation at implantation process control and/or monitoring (that is, determining) device 300.Preferably, building-blocks 320 has the maximum gauge less than 5mm.

Preferably, lead-in wire 328 is included in the flexible insulation metal wire assembly, is convenient to make the power that is delivered to cerebral tissue from skull (will finally be fixed with lead-in wire 328) to minimize.This allows device 300 to move freely.

Think usefully in the disease of tremor symptoms or the illness (for example, Parkinson's disease) though present in treatment up to now, need recognize that the electricity irritation of brain target area effectively also is known in the treatment of other diseases and illness.Therefore, apparatus and method of the present invention are applicable to treating known now or thinking that later on using electricity irritation brain target area is medicable any disease or illness.At present, these diseases or illness comprise, for example melancholia, bipolarity mental disease, mandatory spasm illness and epilepsy.

Just as recognized by those skilled in the art, behavior in the human brain tissue that any device is implanted may cause influence some damage of tissue.Therefore, Ge Ren immune system typically will be reacted to above-mentioned damage.Especially, acute inflammatory reaction is normally tangible in the zone of being damaged.In case acute inflammatory reaction disappears, the seal tissue layer usually forms around institute's implanting device.This may have special negative effect for the function of device, because the seal tissue layer blocks, hinder or with the electric coupling between method for distinguishing countermeasure set and peripheral nerve (for example, the brain) tissue.

Similarly, in the implant procedure process of device itself, it may be polluted by dead cell and/or tissue.This more may be the apparatus surface place that is useful on the adhesion molecule that promotes nervous tissue to be adhered to device (for example, polylysine, laminine, cell Fibronectin, or the like) coated.These materials glue and can be bonded in implantation process on the unexpected material very much, have reduced the function of device thus.

In addition, in the implant procedure process, implant apparatus or nervous tissue by contact, device itself may damage.The latter more may be the equipment place that helps lend some impetus to the accurate topographic structure that contacts between device electrode and the nerve such as pillar etc. comprising.Any " coarse " surface of topographic structure or device also may cause the increase of tissue injury in implantation process.

Therefore, can be contemplated that before implanting with the coated institute of biodegradable protectiveness material implanting device.Fig. 4 shows the sealing device 400 similar to the device 300 of Fig. 3 A.As finding out among Fig. 4, the integral body of device 400 is covered by biodegradable sealer 470.The material that is suitable in sealer 470 using comprises: for example polylactic acid (PLA), polyglycolic acid (PGA), PPDO (PDS), Polyethylene Glycol (PEG), poly butyric fat (PHB).Other suitable materials are certainly come cognitive by those skilled in the art.

Sealer 470 can be suitable for using any method or technology known or research and development afterwards.Preferable methods comprises injection moulding, spraying and vapor deposition.Selected adhoc approach will depend on a large amount of factors such as ideal thickness that comprise device to be sealed, sealer composition and the sealer of finishing certainly.

Sealer 470 provides the dramatic benefit that is better than the non-tight device; comprise: in implantation process protection institute sealing device avoid mechanical damage, protection institute sealing device avoid the pollution of dead cell and/or tissue, protection attachment molecules, because more slick surface is easy to implant, and reduce inflammatory reaction.Inflammatory reaction can further reduce by one or more anti-inflammatory component of incorporating sealer itself into.In the above-described embodiments, when the sealer biodegradation, anti-inflammatory component discharges in institute's implanting device tissue on every side.In order further to increase adhesion and the coupling between nervous tissue and the electrode, promote protein (trophic factors) growth also can be increased to sealer.

As shown in positive Fig. 4, when lead 440...448 is included in sealer 470 when inner, it can have basically " non-segmental " and distributes, in case and sealer 470 complete biodegradable, adopt lead 440 ' ... 448 ' " fan-shaped " distributes.

With more detailed description, sealer 470 can at random form sharp or sharp-pointed leading edge as following, so that sealer 470 itself can be used for running through tissue in the implant procedure process, and helps device 400 is passed the implantation position of its expection.

Fig. 5 A-C shows the progressively biodegradation from the sealer 570 of the implantable device 500 with topographic structure 540,542.In Fig. 5 A, device 500 is sealing fully, and adjacent neurocyte (for example, neuron) 590 contact sealers 570.In Fig. 5 B, the biodegradation of a part of sealer 570 is so that neuron 590 can contact uppermost topographic structure 542.In Fig. 5 C, neuron 570 complete biodegradables, and neuron 590 freely contacts any part of the device 500 that comprises topographic structure 540.

Though it is useful that sealer of the present invention is thought in sealing is used for multi-electrode device that cerebral tissue implants, need recognize that sealer described herein can be applied to any implantable device similarly.Sealer of the present invention require with the fine sealing device that electrically contacts of surrounding tissue in be useful especially.Said apparatus comprises, for example, retina is implanted, dark brain stimulation art (DBS) electrode, be used for for example controlling the recording electrode of the motor cortex of prosthese, and (for example be used to excite nerve activity, be used to stimulate somatosensory cortex or transmit input from other device (for example, photographing unit)) device.The U.S. Provisional Patent Application No.60/701 that said apparatus was submitted on July 21st, 2005 is described in 337 and among the international patent application No.PCT/US2006/052348 that submitted on July 11st, 2006, and each is applied for reference to incorporating into therewith.

As already pointed out, can at random comprise recess or similar characteristics according to device of the present invention, be used for angular orientation and/or rotation at implantation process control and/or monitoring (that is, determining) device.Fig. 6 A-C shows the alternative embodiment of the device 300 that is associated with implantation equipment 600 according to the present invention.As shown in the figure, implantation equipment 600 comprises outer tube 602 and interior pipe 604, and interior pipe 604 has the external diameter that is less than or equal to outer tube 602 internal diameters, so that interior pipe 604 can be in outer tube 602 slides within.As shown in Figure 6A, and in more detail shown in Fig. 6 B, device 300 comprises the bulge 362 that adapts with interior pipe 604 mating features 603, can be inner by passing through outer tube 602 at outer tube 602 as interior pipe 604 so that install 300.Just as the skilled person will recognize, preferred, install 300 angular orientation and rotation at least and can use bulge 362 and mating feature 603 to determine and/or control.As among Fig. 6 A as can be seen, and following with more detailed description, the inner space of pipe 604 in lead-in wire 328 can run through.

Fig. 6 C shows alternative embodiment of the present invention, and wherein, device 300 comprises the recess 360 that is different from bulge as shown in Fig. 6 A-B.Therefore, the mating feature 605 of interior pipe 604 comprises the bulge that is different from groove (grove) as shown in Fig. 6 A-B.Just as the skilled person will recognize, for device 300 and interior pipe 604, can also use other shapes and characteristics combination.

As above pointed, may in implantation process, pollute by dead cell and/or tissue according to device of the present invention.Similarly, in the implantation process of device 300, the inner space of outer tube 602 may be by cell or tissue blockage.Therefore, Fig. 7 A-C shows the illustrative embodiment of implantation equipment 600 layouts that can avoid above-mentioned obstruction.In Fig. 7 A, sharp metal shaft 606 is arranged on the inside, termination of outer tube 602, and it seals or minimize the available opening in the outer tube 602 effectively.In addition, sharp metal shaft 606 must be used for penetrating any tissue in the implantation process of device 300.In Fig. 7 B, arrange each lead 340...348, so that make any opening minimum in the outer tube 602.In Fig. 7 C, as mentioned above, a part of sealer forms sharp edges 372 at the end of lead 340...348.As sharp metal shaft 606, except sealing or minimize the opening in the outer tube 602, sharp edges 372 must be used for penetrating any tissue in the implantation process of device 300.

Fig. 8 A-E shows the illustrative steps of using implantation equipment 600 will install 300 implant procedures successively.In Fig. 8 A, the implantation equipment 600 that contains device 300 is provided with adjacent with brain target area 312.Shown in Fig. 8 B, when interior pipe 604 moved downward, lead 340...348 moved into the target area from the inside of interior pipe 602.In Fig. 8 C, lead 340...348 is fully extended into target area 312.As described above, can arrange (for example, according to length, quantity, relative position) lead 340...348 in advance, so that in a single day extend fully, their distribution is near the volume of target area 312.In Fig. 8 D, interior pipe 604 partly takes out from outer tube 604.As above pointed, pipe 604 in lead-in wire 328 runs through is so that the taking-up of interior pipe 604 is kept intact the remainder of lead-in wire 328 and device.At last, in Fig. 8 E, interior pipe 604 and outer tube 602 take out fully, stay device 300, and lead 340...348 are distributed in 312 inside, target area.If behind apparatus for placing 300, barb 350,352 operationally stretches out, for example, for example when from installing 300 when taking out outer tube 602, they can be suitable for so doing.

For the diagram and purpose of description, by the agency of the aforementioned description of different aspect of the present invention.This does not also mean that it is exhaustive, and limit the invention to disclosed precise forms, and it is evident that, and is possible during many modifications and variations.Be that conspicuous above-mentioned modification and change are intended to be included in the scope of the present invention by top that accessory claim is limit for those skilled in the art.

Claims

1. method of nervous tissue that is used for electricity irritation is delivered to the individual, this method comprises:

Implantable stimulation device (300) in individual's nervous tissue, it comprises:

Building-blocks (320); And

From a plurality of leads (340...348) that building-blocks (320) stretches out, each in a plurality of leads (340...348) contains at least one electrode (342A), so that distribution of electrodes is in the target volume (312) of nervous tissue; And

Use at least one electrode (342A) that nervous tissue is applied electricity irritation.

2. the method for claim 1, wherein building-blocks (320) comprises at least one barb (350), is used for building-blocks (320) is fastened to nervous tissue inside.

3. method as claimed in claim 2, wherein, this at least one barb (350) is suitable in primary importance orientating component piece (320) indentation, and stretches out from building-blocks (320) in the second position.

4. at least one in the method for claim 1, wherein a plurality of leads (340...348) comprises one with top electrode (342A).

5. the method for claim 1, wherein this device (300) further comprises:

Biodegradable sealer (470), it is used at implantation process protection described device (300).

6. method as claimed in claim 5, wherein, when lead (340...348) was included in biodegradable sealer (470) inside, this electrode (342A) was suitable for presenting first and distributes, and presented second distribution when biodegradable sealer (470) biodegradation.

7. method as claimed in claim 5, wherein sealer (470) comprise following at least one: polylactic acid (PLA), polyglycolic acid (PGA), PPDO (PDS), Polyethylene Glycol (PEG) and poly butyric ester (PHB).

8. the method for claim 1 is wherein arranged a plurality of leads (340...348), in advance so that the target volume (312) of the distribution of electrode (342A) and nervous tissue adapts.

9. the method for claim 1, wherein apply and comprise: can be by using than being included in the inner electrode still less of a plurality of electrodes (340...348), electricity irritation is applied to nervous tissue's volume less than maximum volume.

10. the method for claim 1 further comprises:

Use the interior neural activity of target volume (312) of at least one electrode (342A) record nervous tissue.

11. the method for claim 1, wherein electricity irritation can reduce individual trembling of being suffered.

12. method as claimed in claim 11 further comprises:

Apply at least a anti-medicine that trembles to the individual.

13. the method for claim 1, wherein described individual suffers from following at least a disease: Parkinson's disease, depression, bipolar disorder, mandatory spasm illness and epilepsy.

14. an implantable device (300), it comprises:

Building-blocks (320); And

From a plurality of leads (340...348) that building-blocks (320) is dispersed, each in described a plurality of leads (340...348) contains at least one electrode (342A), makes described distribution of electrodes in three dimensions.

15. device as claimed in claim 14, wherein, described building-blocks (320) comprises at least one barb (350), is used for building-blocks (350) is fastened to the organization internal of being implanted.

16. device as claimed in claim 14 comprises further:

At least one lead-in wire (328), it operationally is distributed to stimulation on the building-blocks (320),

Wherein, this building-blocks (320) comprises the electronics duplex circuit, and it operationally is distributed to stimulation at least one electrode (342A).

17. device as claimed in claim 16, wherein, this electronics duplex circuit is by following at least one control: lead-in wire (328) and radio frequency telemetry link.

18. device as claimed in claim 14, wherein, at least one in a plurality of leads (340...348) comprises one with top electrode (342A).

19. device as claimed in claim 14 wherein, is arranged described a plurality of lead (340...348) in advance, makes the distribution of electrode and the target volume (312) of institute's implanting tissue adapt.

20. device as claimed in claim 14 comprises further:

Biodegradable sealer (470) is used at least a portion in implantation process protector (300).

21. device as claimed in claim 20, wherein, described electrode presents first and distributes when being suitable in lead (340...348) is included in biodegradable sealer (470), and presents second distribution when biodegradable sealer (470) biodegradation.

22. device as claimed in claim 20, wherein, described sealer (470) comprises following at least a: polylactic acid (PLA), polyglycolic acid (PGA), PPDO (PDS), Polyethylene Glycol (PEG) and poly butyric ester (PHB).

23. device as claimed in claim 14 further comprises:

Be used at least a instrument in implantation process is determined the angular orientation of this device and rotated.

24. a system that is used to implant implantable device, system comprises:

Implantable device (300), it comprises:

Building-blocks (320); And

From a plurality of leads (340...348) that building-blocks (320) is dispersed, each in described a plurality of leads (340...348) contains at least one electrode (342A), makes this distribution of electrodes in three dimensions; And

Be used to implant the equipment (600) of implantable device (300), it comprises:

Outer tube (602);

Interior pipe (604); And

Mating feature (603) on the interior tube-surface that adapts with the lip-deep feature of implantable device (300) (362),

Wherein, the internal diameter of outer tube (602) external diameter with interior pipe (604) at least is the same big, so that implantable device (300) can move through outer tube (602) through interior pipe (604).

25. system as claimed in claim 24, wherein, building-blocks (320) comprises at least one barb (350), is used for building-blocks (320) is fastened to the organization internal of being implanted.

26. system as claimed in claim 24, wherein, at least one comprises more than one electrode (342A) in described a plurality of leads (340...348).

27. system as claimed in claim 24 wherein, arranges described a plurality of lead (340...348) in advance, makes the distribution of electrode and the target volume of implanting tissue (312) adapt.

28. system as claimed in claim 24 further comprises:

Biodegradable sealer (470), it is used at least a portion at the implantation process described device of protection (300).

29. system as claimed in claim 28, wherein, described electrode presents first and distributes when being suitable in lead (340...348) is included in biodegradable sealer (470), and presents second distribution when biodegradable sealer (470) biodegradation.

30. device as claimed in claim 28, wherein, described sealer (470) comprises following at least a: polylactic acid (PLA), polyglycolic acid (PGA), PPDO (PDS), Polyethylene Glycol (PEG) and poly butyric ester (PHB).

31. system as claimed in claim 28 further comprises:

Be used at least a instrument in implantation process is determined the angular orientation of device (300) and rotated.

32. system as claimed in claim 24, wherein, the interior pipe (604) of described implantation equipment (600) is suitable for including at least one lead-in wire (328) of implantable device (300).

33. an equipment (600) that is used to implant implantable device, it comprises:

Outer tube (602);

Interior pipe (604); And

The lip-deep mating feature of interior pipe (604) (603) that adapts with the lip-deep feature of implantable device (300) (362),

34. equipment as claimed in claim 33, wherein, at least a can the control in the angular orientation of implantable device (300) and the rotation by operating this mating feature.

35. equipment as claimed in claim 33, wherein, the lip-deep feature of described implantable device (300) (362) comprises at least a in following: recess or protuberance.

36. equipment as claimed in claim 33, wherein, interior pipe (604) is suitable for comprising at least one lead-in wire (328) of implantable device.

37. a method that is used to protect implantable device (300), this method comprises: the surface that sealer (470) is applied at least a portion of implantable device (300).

38. method as claimed in claim 37, wherein, described sealer (470) comprises at least a composition that is selected from the group that is made of polylactic acid (PLA), polyglycolic acid (PGA), PPDO (PDS), Polyethylene Glycol (PEG) and poly butyric ester (PHB).

39. method as claimed in claim 37 wherein, applies and comprises at least a in injection moulding, spraying and the vapor deposition.

40. method as claimed in claim 37, wherein, described sealer (470) further comprises operationally discharge at least a in following when the sealer biodegradation: anti-inflammatory medicaments and growth protein.

41. an implantable device (300), it comprises the sealer that applies according to claim 37 method.