CN101489612A - Variable dose inhalation device - Google Patents
Variable dose inhalation device Download PDFInfo
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- CN101489612A CN101489612A CNA200780012364XA CN200780012364A CN101489612A CN 101489612 A CN101489612 A CN 101489612A CN A200780012364X A CNA200780012364X A CN A200780012364XA CN 200780012364 A CN200780012364 A CN 200780012364A CN 101489612 A CN101489612 A CN 101489612A
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Abstract
An inhaler contains one or more vibrator mechanisms in one or more powder dispensing chambers for delivery of varying doses of a therapeutic agent or drug.
Description
Technical field
The present invention relates generally to the suction apparatus field.The present invention is utilizing facilitated therapeutic agent or medicine to be particularly useful with the suction apparatus aspect that powder or liquid form are suspended to the air-flow that is inhaled into (for example, sucking air), and will should be used for describing in conjunction with this, also expects other application certainly.
Background technology
The disease of known some respiratory tract is replied the treatment generation of direct administering therapeutic agent or medicine.Obtain with dry powder form because these reagent or medicine are the easiest, so their the most convenient ground of using is to suck powdered rubber by per nasal or per os to finish.These powder types since reagent or medicine deposit to the site of expectation exactly and may need the site of its effect and this reagent or medicine are produced better application; Therefore, very Xiao Jiliang reagent or medicine usually with give by additive method more heavy dose of the same effective, the result is that the generation of the side effect do not expected (comprise underdosage or overdose and above the risk of cost) significantly reduces.Perhaps, reagent or the medicine with this form can be used for treating those diseases except respiratory system.When reagent or drug deposition during in the very large lung areas of surface area, it may be absorbed rapidly by blood flow; Therefore, this application process can replace the administration by injection, tablet or other conventional methods.
The viewpoint of medical industry is that most bioavailability of medicament is best when the drug particles that is delivered to respiratory tract is about 1 to 5 micron big or small.Yet, there are some problems with this size range delivering drugs granule:
(1) undersized granule is being made and is being produced electrostatic charge between the storage life.This causes particle agglomeration or gathering, produces to have effective dimensions greater than about 5 microns cluster of particle.These probabilities of big bunch cause it to arrive dark pulmonary to reduce then.It is lower that this causes the patient can obtain the percentage ratio of the medicine that is used to absorb conversely.
(2) order of magnitude of the amount that need be delivered to patient's active medicine (for example tens) microgram that may only be a little.For example, albuterol, under the situation of the medicine that is used for asthma, it is 25 to 50 micrograms normally.Present manufacturing equipment can be sent the drug moiety of milligram dosage range effectively with acceptable accuracy.Therefore, the practice of standard is to mix with active medicine and excipient filler or such as the filler of lactose.This additive also makes medicine " be easy to flow ".Because drug particles is also by static or chemical bond these granules that bond, so this filler also is known as carrier.These carrier granulars are dimensionally much larger than drug particles.The ability of Diskus separate drug from carrier is important performance parameter at the design effectiveness.
(3) having size will deposit in mouth or larynx greater than about 5 microns active drug particles.This causes the uncertainty of another level, because bioavailability and the absorption of medicine in these positions is different from lung.Diskus need make the minimal drug that is deposited on these positions to reduce the uncertainty relevant with drug bioavailability.
The Diskus of prior art (DPIs) has usually medicine (active medicine adds carrier) is introduced into instrument in the high velocity air.This high velocity air is used as to be made micron-sized cluster of particle decomposition or makes drug particles isolating principal organ from carrier.The dispersive suction apparatus of powder type that is used to make this medicament more known in the state of the art.For example, such suction apparatus is disclosed in the U.S. Patent No. 3507277,3518992,3635219,3795244 and 3807400, it has and is used to pierce through the capsular instrument that contains Powdered medicament, and when sucking, medicament is drawn out of and enters from the capsule that pierces through in the mouth of user.In these patents some disclose propeller means, and it is assisted powder is disperseed to come out from capsule when sucking, and suck air suction powder from capsule so that do not need to rely on separately.For example, U.S. Patent No. 2517482 discloses to have in suction and has been prepended to the device that contains Sprinkle Caps in the lower chambers, depresses pecker and pierces through this capsule by user is manual.After piercing through, begin to suck and capsule is introduced into the upper chamber of this device, it moves to cause powder to disperse by pierced holes and to enter the suction air-flow with all directions in upper chamber.U.S. Patent No. 3831606 disclose have a plurality of peckers, propeller means and self-powered suction apparatus, this is self-powered control propeller means so that when sucking by outside manual operations, and propeller means is auxiliary to be distributed to powder in the suction air flow.Also referring to U.S. Patent No. 5458135.
The prior art major part of above-mentioned explanation is from people's such as Wilke U.S. Patent No. 3948264, and they disclose the device that is used to promote the powder medicine suction, comprises having elementary and the secondary air admission passage and the passage of going out.This secondary admission passage provides cavity and this is gone out passage and forms from the outstanding mouth of pipe of main body to the capsule that contains powder medicine.Provide a kind of capsule to pierce through structure, it causes one or more holes so that when capsule is vibrated by electromechanical vibrator in capsule when rotating, can discharge powder medicaments from capsule.People such as Wilke are disclosed to pierce through instrument and comprises that three thorns that are installed in the trochoidal curve chamber vertically arranged, bias spring thread a needle.When the hand rotation chamber, this pin inwardly moves radially and pierce through capsule simultaneously.The further rotation of chamber makes the initial position that is fixed to them by the pin that its spring shrank to regain pin from capsule.This electromechanical vibrator is at its inner terminal involving vibrations plunger rod, and it is projected into admission passage and goes out the crossing of passage.The solenoid buzzer that this bar energising is vibrated is connected to this thromboembolism bar.This buzzer is activated by the high energy battery power supply and by the outer button switch.According to people such as Wilke, when sucking and to press switch simultaneously when activating motor machine vibration tool by going out passage, air is inhaled into by one or more admission passage and air communication is crossed the secondary admission passage capsule is improved for vibration thromboembolism bar.Therefore rapidly capsule is vibration, and powder is fluidized and disperse from pierced holes in capsule.This technology is used usually in the mill with by the hopper dispersed powders, and this hopper vibration is so that powder fluidisation and it is moved by hopper outlet.Puncturing hole in the capsule is represented hopper outlet.Air-flow by admission passage helps from capsule withdrawal of powder and this powder is brought in the mouth of user by going out passage.People such as Wilke further disclose electromechanical vibrator means may with enter chamber and meet at right angles and be placed and can change the amplitude of vibration and frequency to regulate the dispersing character of inhaler.
The electromechanical device that the vibrator of the disclosed inhalers of people such as Wilke is made up of the bar that is driven by solenoid buzzer.According to people such as Wilke, this electromechanical means may be the motor-driven cam.The shortcoming of the disclosed inhaler instrument of Wilke is that bar needs big relatively mechanical movement to vibrate capsule effectively.Because the elasticity of capsule wall and medicine and capsular inertia need the big motion of the usually nearly hundreds of micron of this bar.
Solenoid buzzer has operating frequency usually less than 5kHz.Therefore this operating frequency is tending towards noisy and when being attached to Diskus, from patient's angle, does not expect.A shortcoming again of the electromechanical actuators of Wilke need to be high capacity power source, therefore, needs a large amount of battery sources or to the frequent replacing of the set of cells of portable unit.From patient's safety and the position of " being easy to use ", these characteristics are not expected.
With respect to other inhaler of quoting in the open text of this patent, people's such as Wilke inhaler mainly is intended to reduce amount of powder remaining in the capsule.Yet, people such as Wilke do not propose with powder depolymerize to particle size or combination as effectively send medicament to lung required dimensionally less than 6 microns needs; On the contrary, the inhaler of people such as Wilke and prior art is the same, continues to depend on air velocity so that inject the powder of air-flow to depolymerize to the particle size that is suitable for being delivered to lung.
Another suction apparatus is open in people's such as Burns U.S. Patent No. 5284133 in the prior art.In this device, liquid preparation is by the Vltrasonic device atomizing such as piezoelectric element.Usually be in high speed airflow, or propellant brings to the patient with this atomizing particle subsequently.Yet the required energy of this liquid preparation of atomizing may be very high in nebulizer, makes this delivering drugs only feasible on desktop unit basically to the method for lung.
Therefore, prior-art devices has some shortcomings, comprising:
The performance of the inhaler of prior art depends on the flow velocity that user produces.Lower flow velocity may not cause the whole depolymerization of powder quilt and therefore the dosage that is delivered to the patient be had side effects.
Because lack the concordance of separating collecting process, therefore, the bioavailability of medicament between various dose is inconsistent.
Drive motor tool class inhaler needs huge energy, and it increases this device size.
Another shortcoming of prior-art devices is only to send the ability of the medicine of fixed dosage to the patient, yet the patient can change according to the current state of patient's medical symptom for the demand of medication dosing.For example, diabetics may the not commensurability insulin of needs according to the measurement of concentration of glucose in the blood samples of patients.
Won, transfer commonly-assigned us MicrodoseTechnologies on the 9th at applicant's December in 1997, Inc. in the previous U.S. Patent No. 5694920, provide and utilized the inhaler of facilitated powder suspension at gas, it has overcome above-mentioned aforementioned and other shortcoming and disadvantage of the prior art.More specifically, the inhaler of applicant's aforementioned patent comprises the piezoelectric vibrator that is used to vibrate powder.Provide controller with control (being amplitude and/or frequency) thus supply with driving electric to vibrator and cause at least a portion that is suitable for this powder to be suspended in powder vibration in the gas best.As described in applicant's aforementioned patent, controller can comprise the control that user drives, frequency of vibration and/or amplitude that the powder type that is used for allowing user to select to be used at present inhaler suspends in gas best.The control that this user drives is suspended to mode in the gas with the controller pre-calibration best with at least a portion with this powder, causes controller to regulate the frequency of the driving electric of supplying with this vibrator and/or the selected powder type of controller that amplitude to user drives is vibrated required frequency and/or amplitude.The control that user drives can comprise by the average-size that will be suspended in the powder particle in the gas and/or by required frequency of vibration and amplitude selects rank.For these normally used powder particles are suspended in the gas best, frequency of vibration will be adjusted at least about 12kHz.Certainly, frequency of vibration and amplitude can be adjusted to the best powder medicine to be used that suspends.
Pass air-flow and set up electrostatic field, its intensity by the control electrostatic field is only introduced air-flow with the purpose particle size basically, and larger sized granule is left in the container.So this has reduced the discordance relevant with drug bioavailability because deposit to the bulky grain of mouth or larynx usually with device described in the prior.
The applicant wins, also transfers Microdose Technologies on November 7th, 2000, Inc. another formerly U.S. Patent No. 6142146 provides inhaler, its piezoelectric element is designed to different amplitudes and frequency vibration, promptly, for example, to such an extent as to two kinds of different medicines can disperse from same inhaler valuably simultaneously, and do not influence the performance of every kind of medicine.This allows to send two kinds of medicines that activity arranged together but may not easily store together.For example, can provide the asthma inhaler that contains such as the bronchodilator of albuterol and can need the cholesterol that different piezoelectricity are provided with.
Similarly, people such as Coffee have instructed the inhaler that uses two or more piezo-electric resonators in the U.S. Patent No. 6684879 that on February 3rd, 2004 won, and this resonator is configured to different frequency resonances so that the drop atomizing is scattered.
Summary of the invention
The invention provides improvement to the suction apparatus of the prior art of all U.S. Patent No.s of mentioning as described above 6142146.The present invention allows user easily to give the therapeutic agent or the medicine of various dose.As used herein, term " medicament ", " therapeutic agent ", " reagent " and " medicine " are used interchangeably.The inhaler of prior art only allows user once to give separately or the limited dosage of numbers of poles.The present invention allows user to give the various dose of one or more therapeutic agents or medicine with independent or controlled suction number.The suction number that restriction gives the combination of the medicament of desired amount or different medicaments causes the adaptability and the effectiveness that improve.
For example, consider to use the inhaler delivery of powered insulin.The available inhaler that is used for delivery of powered insulin all is a single dose device at present.Yet, the people who suffers from diabetes according to the measured value of their blood sugar levels when measuring may needs one day repeatedly, the insulin of various dose.This means user or must carry a plurality of suction apparatus that each suction apparatus is sent various dose that perhaps the patient must breathe so that finish the dosage of expectation continuously several times.Inhaler of the present invention provide effectively and easily approach to suck the insulin that various dose is provided in the step at one.
In the embodiment, the invention provides the inhaler that has two (or a plurality of) vibrator mechanisms or piezoelectric element and can write the dose pack of address (addressable).Therefore, inhaler of the present invention can be with the single inhaler that is inserted into of the blister packs (blister) of the snap action insulin of various dose to provide the dosage that needs.For example, if user needs the insulin of 8 units, the inhaler and disperse of the blister packs of the blister packs of 5 units and 3 units can being packed into a round.Therefore, inhaler of the present invention provides not commensurability medicament simply and effectively to give, and without the required repeatedly suction of the inhaler of prior art.
In another embodiment of the present invention, inhaler contains two or more vibrator mechanisms or piezoelectric element, its each be arranged in powder dispersion chamber separately.The inhaler structure allows single medicine blister packs that user can contain the drug dose of identical or different size to insert inhaler to be used for a round and to send.In second embodiment of inhaler, two or more vibrator mechanisms or piezoelectric element are arranged in same powder dispersion chamber.
In the embodiment more of the present invention, two (or a plurality of) cartridge strip are inserted into the rear portion of inhaler.Each band contains one or more blister packs that contain medicine or medicine.User is selected medicine or the drug dose expected by one or more blister packs of choosing one or two (or more) cartridge steps.
In the another embodiment of the invention, anchor clamps that the use permission is selected or instrument are with single medicine or the medicine blister packs is inserted and the obstructed abutment of receiving and distributing is handled this blister packs.
In the another embodiment of the invention, blister packs is packaged on reel or the rotatable cartridge and once falls or be put in the inhaler.
In another embodiment of the present invention (shown in Figure 13), the a plurality of blister packs or the platinum capsule that contain medicine can be by vibrator mechanisms or piezoelectric element activate separately, opened simultaneously or pierced through and before administration, be exposed to resonator cavity simultaneously, thereby make by penetrating the medicine that medicine is sent variable dose from resonator cavity, for example, by the synthetic injection according to the US2005/0183724-A1 instruction, its content is incorporated herein by reference.
In the another embodiment of the invention (shown in Figure 14), by using at least one vibrator mechanisms or piezoelectric element, the medicine of variable dose is delivered to the patient, use this vibrator mechanisms or piezoelectric element simultaneously or in a sequence to activate the multiple choices dose pack so that be created in the medicine of sending given dose when once sucking, wherein this dosage can change according to patient's needs.In this embodiment, the combination results of some more low dose of encapsulation satisfies the controlled accumulated dose of needs of patients.Preferred blister packs of dose pack or platinum capsule.According to this embodiment of the present invention, dose package comprises on the platinum or blister packs is interior a plurality of loculuses or micro-blister, they are once sucking/are moving continuously or off and on when giving medicine, by vibrator or piezoelectric element or other thermo-mechanical drive, wherein, the variable dose that is delivered to the patient in once sucking is defined in the loculus that is opened when sucking or pierces through or micro-blister and gives patient's quantity.In the embodiment, each micro-blister can contain the medicine of same amount, for example the medicine of 0.5mg.For medicine from 1mg to the patient that send, 2 micro-blister are opened or pierce through.Similarly, for the medicine of sending 2mg, 4 micro-blister are opened or pierce through.
In the another embodiment of the invention (shown in Figure 15), by using at least one vibrator mechanisms or piezoelectric element the medicine of variable dose is delivered to the patient, this vibrator mechanisms or piezoelectric element are used to drive simultaneously one or more dose pack.The quantity of driven dose pack will determine to be delivered to patient's accumulated dose.
In the another embodiment of the invention (shown in Figure 16), provide pick off monitoring the amount of the passive medicine that send, this medicine is given with dose pack or the encapsulation that contains above the medication amount of needs of patients amount.In case need dosage to be delivered to the patient, so pick off stop medicine sending and abandon residual drug or give over to after give.The particulate optics of aerosol (aerosol) or the acoustic sensor of suction apparatus flow duct preferably can be monitored and quantize to move through to pick off.Another embodiment of pick off is the pick off that the medication amount in blister packs or dose pack or the encapsulation is stayed in monitoring, wherein, and the preferred quartz microbalance sensor of pick off or piezoelectric transducer or acoustic sensor.In the embodiment, be used for driving and the piezoelectric element that vibrates medicine also as pick off to monitor the medication amount of staying cell-shell or dose pack by this dose pack of measurement or the resonant frequency of blister packs or the motor machine parameter (for example admittance of piezoelectric actuator) of piezoelectric actuator.In another embodiment, acoustic sensor is used as the acoustic characteristic that detects cell-shell or measures the resonant acoustic wave that produces in this cell-shell and therefore monitor the medication amount of still staying in the cell-shell.In case this pick off monitors required medication amount by the aerosol granule of measuring residual drug amount or quantification and moving through flow duct and has been delivered to the patient, pick off sends signal to stop the delivering drugs to the patient to control circuit so.In another embodiment, pick off is by measuring the optical transmission by dose pack or cell-shell, and the medication amount in dose pack or the cell-shell is stayed in monitoring optically.
In the another embodiment of the invention (shown in Figure 17), contain the quantitatively tube of above medication amount of enough medicines.This has the outlet that communicates with the quantitative plate and first valve plate, the preferred form of this quantitative plate comprises the rotatable disc with identical or variable-sized little quantitative chamber, the preferred form of this first valve plate be included in tube and quantitatively between the plate localized first rotatable cover allowing to select to be used to fill the chamber number of medicine, thereby allow to select the variable dose of medicine.In this embodiment, first valve plate allows to open towards the chamber of the selection quantity that is used to fill medicine from tube.Second valve plate is between the resonator cavity of quantitatively plate and inhaler, and its preferred form comprises second rotatable disc, uses vibrator mechanisms or piezoelectric element to carry out that medicine is sent so that medicine is vaporific scatters and sent from this resonator cavity.In the use, first valve plate is opened so that select specific microcavity number corresponding to desired amount.Fill selected chamber from tube then.First valve cuts out and second valve is opened to allow medicine to be transferred to that resonator cavity is used for atomizing and to penetrate and be delivered to the patient from resonator cavity then, for example by the synthetic injection according to US2005/0183724-A1 instructed.
In the embodiment more of the present invention, from Delivery time and suitable calibration curve estimation dosage delivered, wherein, the vibration of drug pack or cell-shell or Piezoelectric Driving time are proofreaied and correct by dosage delivered.This after embodiment in, will need dosage to send by control medicine Delivery time or the time that more specifically vibrator mechanisms or piezoelectric element is contacted with drug pack be activated by control or load cycle.In this embodiment, all medication amount that contain in perhaps single drug pack or the cell-shell are sent with maximal dose, and the part medication amount that contains in perhaps single drug pack or the cell-shell is sent as the more low dosage of medicine.Turn off vibrating elements before sending by the whole dosage that in single drug pack, contains, the variable dose medicine can be delivered to the patient.Perhaps, can the medicine of variable drug dose be delivered to the patient by producing lower vibratory drive, perhaps be delivered to the patient by switching opening of output discontinuously and close with lower load cycle operation vibrating elements with more low-yield input operation vibrating elements.
Description of drawings
To find out other method of the present invention, device, feature and advantage from following accompanying drawing with describing in detail.Other method of all these kinds, device, feature and advantage intention comprise in this manual, comprise within the scope of the invention, and are protected by claims.
With reference to the accompanying drawings, many aspects that the present invention may be better understood.Assembly in the accompanying drawing must not amplify, and emphasizes when clearly principle of the present invention being described.In the accompanying drawing, identical reference number is represented corresponding parts in some diagrammatic sketch, wherein:
Fig. 1 is the longitudinal cross-section sketch map of the inhaler of first embodiment that carries out according to the present invention;
Fig. 2 is the perspective view of the inhaler of Fig. 1;
Fig. 3 is the pharmacy used in first embodiment of the present invention of Fig. 4 or the birds-eye perspective of medicine blister packs or cartridge case;
Fig. 6 is the longitudinal cross-section sketch map of second embodiment of the present invention;
Fig. 7 is the birds-eye perspective of the 3rd embodiment of the present invention;
Fig. 8 is the birds-eye perspective of the used cartridge case band of the 3rd embodiment of the present invention of Fig. 7;
Fig. 9 is the birds-eye perspective of the 4th embodiment of the present invention;
Figure 10 is another birds-eye perspective of the 4th embodiment of the present invention of Fig. 9;
Figure 11 is the used cryptomere jar (pitcher) of the 4th embodiment of the present invention of Fig. 9-10 and the birds-eye perspective of second storage device;
Figure 12 is the birds-eye perspective of the 5th embodiment of the present invention and the reel (spool) that uses with inhaler; With
Figure 13-17 illustrates other embodiment of the present invention.
The specific embodiment
Fig. 1-3 illustrates first embodiment of the present invention.Inhaler 10 comprises having duroplasts L-shape longitudinal cross-section, that have mouthpiece cover 11 or metal-back 18 usually.This shell 18 comprises four gas flow openings 20,28,30 and 32.Inhaler 10 comprises main air flow passage 26, and its front end 22 from shell 18 (opening 20) is to its rear portion 24 (opening 28 places) development length and have square lateral cross section usually, so that allow air to flow through (representing with arrow among Fig. 3).
Selectable second air conduit 31 is normally L shaped and vertically advance to main channel 26 from the opening 30 on 24 surfaces, rear portion of shell 18.One-way flow valve 50 is installed in the inner surface of main channel 26 by biasing spring linkwork (not shown), when the pressure of air flow F in the trunk line 26 is lower than when showing that user passes through predetermined threshold that passage 26 sucks, this biasing spring linkwork be suitable for causing valve 50 block fully air flow S by conduit 31 to trunk line 26.
Form the cartridge case 34,35 that two powder dispersion chamber 54,55 are used to hold powder medicine to be sucked in the shell 18.Shell 18 comprises that hinged mobile plate portion 75 is to allow to contain the blister packs or the cartridge case 34 of medicine or medicine in the rear portion 24,35 are introduced into two chambers 54,55 and be placed to the vibrating mechanism 36 between four steering tool 60A, 60B, 60C, 60D respectively, 37 the seat 52 on so that cartridge case 34,35 mechanically are coupled to cartridge case 34,35 to allow from vibrating mechanism 36,37 the maximum vibration energy delivery to cartridge case 34,35. Steering tool 60A, 60B, 60C, 60D are designed to allow from any secondary encapsulation (not shown) is manual and easily insert cartridge case 34,35 and capsule is retained on the seat 52 in two chambers 54,55.Preferably, mouthpiece cover 11 hinged boards rotationally 75.
Inhaler 10 also preferably includes the conventional small-sized air velocity that is installed in conduit 26 inner surfacies or pressure transducer 40 so that speed and/or the pressure of induction air flow F.Preferably, pick off 40 comprises baffle plate sinking (flapper-yield) switch of spring loaded, it produces the flow velocity of the air flow F of indication in conduit 26 and/or the signal of telecommunication of pressure, and transmits those signals with the startup based on those signal controlling vibrator mechanisms.Perhaps, pick off 40 can comprise pressure transducer or sound transducer and control, is for example transferring Microdose Technologies, described in the U.S. Patent No. 6152130 of Inc..
Preferably, control circuit 48 is as using the specific IC chip and/or the height IC chip of some other types.Perhaps, control circuit 48 can adopt the form of microprocessor, perhaps discrete electrical and electronic building brick.
The present invention also discloses not to be had selectable air conduit 30 and does not have gas flow opening 30 and the embodiment of the inhaler of valve 50.In this embodiment, drug powder directly is discharged into primary air pipeline 26.
In this first embodiment of the present invention, medicine is stored in the single blister packs 34,35 with unit dose.Specifically with reference to figure 3, this single blister packs 34,35 contains two parts: the substrate 92 of cell-shell 90 and labelling.This cell-shell 90 contains the controlled part or the dosage of dry powder pharmaceutical or liquid medicine.The substrate 92 of this labelling is used for some purposes: it provides about the sort of type of cell-shell Chinese medicine or medicament and the information of amount; It supports this cell-shell; And it provides the handle that easily cell- shell 34,35 is loaded into inhaler 10.Big numeral on the labelling 92 or other marks (under this situation, numeral " 9IU ") show that this blister packs contains the insulin of 9 units.The dose pack of other sizes, for example, the encapsulation of 3 units will allow user to select the dosage of 3,6,9 or 12 units by the combination of selecting one or two blister packs in once breathing.Similarly, the blister packs that contains 1,2 and 4 unit will allow user to select the dosage of 1,2,3,4,5,6 and 8 units by the combination of selecting one or two blister packs in once breathing.Similar mode, the blister packs that contains 3,4 and 5 units will allow user to select the dosage of 3,4,5,6,7,8,9 or 10 units by the combination of selecting one or two blister packs in once breathing.Big numbering make user easily the blister packs of calculation expectation combination and be inserted in the inhaler.This blister packs 34,35 also can contain readable labelling of electricity or mechanics or label; This labelling or label contain the information relevant for cell-shell content.Inhaler can comprise that the mechanism that reads this information receives the correct dose of correct medicine to check user.
Second preferred implementation 100 of the present invention as shown in Figure 4.In this embodiment, 100 of inhalers contain a powder dispersion chamber 102.This chamber 102 contains two vibrating mechanisms 104,106, and it makes two blister packs 34,35 be placed on the seat of vibrating mechanism 104,106.Comprise air flow P from the medicine of two cartridge cases 34,35 path 10 8 of flowing through, by conduit 31 to main channel 26.
Fig. 5-6 illustrates the 3rd embodiment 202 of the present invention.In this embodiment, inhaler is configured to receive a pair of cartridge strip (only illustrate one of them 214), and they are inserted in the groove (not shown) at rear portion 204 of inhaler 202.Mouthpiece cover 206 (not shown) are hinged rotationally at the attached mouth of pipe (not shown) of inhaler front end.Each cartridge strips has a plurality of blister packs 34.Preferably, all blister packs 34 on particular bands contain the medicament of same amount.User is loaded in the inhaler by two cartridge strip that will have different blister packs, and the button 212 at slip inhaler 202 tops is controlled desired medicine or drug dose with one or more blister packs of choosing and pierce through on each band.In case user has selected dosage and this cell-shell 90 of expectation to be pierced, piezoelectric vibrator just makes the medicament depolymerization so.Preferably, flow-sensint unit and feedback (for example laid-open U.S. Patents No.US2003/0041859-A1 is described) such as noise generator or one or more lamp 210 can be provided, with remind user when this medicine correctly sucked and when this is quantitatively finished.According to required accumulated dose, user may need switch cartridge strips and suck once more or suck in addition with same cartridge case.After user sucked, band separately was pushed into through used cell-shell, for example as film camera.Preferably, thus be when transparent permission user has observed these band 214 skies around the lid 208 of band 214.
Fig. 6 illustrates the cartridge strip 214 consistent with the 3rd preferred implementation of the present invention.This cartridge strip 214 has the labelling of printing thereon or the cartridge case 34 of mark is formed by a plurality of.
Shown in Fig. 7-9; the 4th embodiment 300 of the present invention allows user to select single cell-shell 90 or its combinations from the cartridge case of protection, and the receiving slit 312 that one or two cell-shell 90 usefulness anchor clamps or instrument 314 is inserted in the inhalers 300 according to the dosage of required medicine.As described in the early time, this inhaler can comprise such as the flow-sensint unit of noise generator or lamp 310 and feedback with remind user when this medicine correctly sucked and when this is quantitatively finished.In addition, do not suck if user is correct, inhaler 300 can be programmed to stop this dosage and correctly suck up to user.This inhaler 300 also can be programmed with the summation of calculating dispersive number of blisters and the running total amount that is kept for continuing quantitative incident, and shows this total amount on LCD302 etc.
In this embodiment, second packaging system or protection cartridge case 320 are protected before single cell-shell 90 uses and are stored it.This second packaging system 320 contains groove 322 with fixing cell-shell 90.Cell-shell 90 is by using anchor clamps or instrument 314 to finish from second packaging system 320 to the mobile of inhaler 300.Anchor clamps or instrument 321 preferably include have groove pair of parallel track 324 to allow collecting cell-shell 90 easily.Protective cover 316 on anchor clamps or the instrument 314 is owing to protecting cell-shell 90 in the cartridge case and the transhipment of the Tool Room that is used.Anchor clamps or instrument 314 are inserted in the cartridge case 320 to catch cell-shell 34 by groove 322.The opening 312 that user is regained anchor clamps or instrument 314 then and moved it and be inserted into inhaler 300.When inhaler was used, these anchor clamps or instrument 314 were left on original position.Take away these anchor clamps or instrument 314 then, take out exhausted cell-shell with it.Use the feature and advantage of anchor clamps or instrument to be to avoid by the hands of user or finger contact to pollution that cell-shell caused or possible infringement.
As shown in figure 10, the 5th embodiment of the present invention uses reel or rotating disk 402 with protection cell-shell 90 before sending.During use, rotating disk 402 is installed in the groove 404 of inhaler 400.Rotate this rotating disk 402 so that cell-shell 90 is delivered to opening 410.Cell-shell 90 is fallen from groove 404, enter inhaler by opening 410, cell-shell can be also processed as being opened in the past in inhaler.Each all contains the medicine of same dose the cell-shell that contains in the reel rotating disk.Figure 11-12 illustrates other encapsulation technologies and the structure that is used to protect cell-shell.
With reference now to Figure 13 A and 13B,, embodiments of the present invention comprise resonator cavity 500, and drug substance atomizing is scattered for it and from 510 ejaculations of medicine ejecting device, this resonator cavity 500 is driven by the vibrator 530 with its coupling connection, for example piezoelectric actuator or transducers.Provide dose pack or blister delivery window 520 to deposit to resonator cavity 500 with drug substance with variable.Utilize winding propulsive mechanism engagement cell-shell winding 540 and before quantitatively propelling so that contain the dose pack or the cell-shell of medicine and contact with delivery window 520.In this embodiment, the cell-shell 550 of selected quantity the sending that be pierced or be opened in the cell-shell winding 540 with the medicine that causes desired amount.In this embodiment, a plurality of dose pack 550 are opened simultaneously by 530 activation of a vibrator and were exposed to resonator cavity 520 simultaneously before giving medicine, thereby make the medicine of sending variable dose by penetrating medicine from resonator cavity, for example spray by synthetic.
With reference now to Figure 14 A,, in another embodiment of the present invention, by using at least one vibrator 690 that the medicine of variable dose is delivered to the patient, this vibrator is piezoelectric element for example, thereby it simultaneously or sequentially activate a plurality of selected dose pack 630 or 635 and cause sending the medicine of certain desired amount, preferably once to suck.This dosage delivered can change by selecting one or more dose pack 630 or 635 according to patient's needs.Shown in Figure 14 B and 14C, with dose pack 630 and 635 on winding 600,610 or 620 with one or many rows be provided with, and can be shape-variable, for example circular dose pack 630 shown in Figure 14 D or microscler dose pack 635.Dose pack 630 and 635 preferred cell-shells or the anologue cavity that in the carrier winding 600,610 or 620 of the fixing medicine of scheduled volume, forms.In the embodiment, vibrator 690 surfaces are passed in winding 600 continuously or discontinuously, and it covers winding (lidding tape) 680 and comes off from single dose pack 630 by push rod (peel) mechanism 680.Winding 600 is advanced from reel 670 by winding propulsive mechanism 660.The moving direction of separated drug when vibrator 690 drives penetrated and is atomized in arrow 650 indications.The quantity that is delivered to the dose pack 630 that patient's drug dose is opened controls and contacts with piezoelectric actuator during medicine is sent incident.According to this embodiment of the present invention, dose pack 630 or 635 comprises a plurality of loculuses or micro-blister on winding or capsule or in blister packs, it is once sucking/when giving medicine, move continuously or discontinuously, by vibrator or piezoelectric element or other mechanism's drivers, the variable dose that wherein is delivered to the patient when once sucking is opened when sucking or is pierced and is limited to loculus or micro-blister that the patient gives.In the embodiment, each micro-blister or dose pack 630 can contain the medicine of same amount, for example, and the medicine of 0.5mg.In order to send the medicine of 1mg to the patient, 2 micro-blister are opened or pierce through.Similarly, in order to send the medicine of 2mg, 4 micro-blister are opened or pierce through.
With reference now to 14E,, an embodiment of the invention are shown, wherein the dose pack of selected quantity or micro-blister 630 pierce through by the top cover with this dose pack and are opened, thereby make ejaculation medicine (not shown puncturing mechanism) when contact vibration device 690.In this embodiment, a plurality of micro-blister or dose pack 690 are quantitatively contacting in the incident with vibrator 690.The ejaculation of medicine is only carried out from the micro-blister that is pierced or is opened or dose pack 690, thereby the quantity of micro-blister that is pierced or opens or dose pack 690 selects to limit the variable dose of the medicine that is delivered to the patient.The moving direction of the medicine that scatters is penetrated and is atomized in arrow 650 indications when vibrator 690 drives.
With reference now to Figure 15 A and 15B,, in another embodiment of the present invention, the medicine of variable dose is delivered to the patient by using at least one vibrator 700, this vibrator is as driving one or more dose pack 710 simultaneously.The quantity of driven dose pack will determine to be delivered to patient's accumulated dose.Figure 15 A illustrates from a plurality of dose pack that are pierced or open 710 and sends high amount of drug, and the atomizing of arrow 720 schematically illustrated medicines is scattered and penetrated.
Figure 15 B illustrates from a dose pack that is pierced or opens 710 and sends small quantities of drugs, and the atomizing of arrow 720 schematically illustrated medicines is scattered and penetrated.In this embodiment, the variable dose of medicine is limited by the quantity of dose pack that is pierced or opens or cell-shell 710.
In another embodiment of the present invention shown in Figure 15 C and the 15D, the single dose pack by selecting to be pierced or to open and all to be coupled to vibrator 700 or the quantity of cell-shell 710 are carried out the medicine of variable dose and are sent.A single dose pack 710 is shown Figure 15 C and Figure 15 D illustrates three individually dosed encapsulation 710, and wherein the atomizing of arrow 720 schematically illustrated medicines is scattered and penetrated.
Figure 16 A and 16B illustrate another embodiment of the present invention, wherein provide pick off or monitor to be used to monitor amount by delivering drugs.From containing greater than penetrating medicine the dose pack of the medication amount of needs of patients amount or the encapsulation.In case must be delivered to the patient by dosage, the medicine that stops and being left of sending of medicine is dropped or is preserved for later giving so, causes sending the medicine of variable dose.Send by interrupting providing the driving of the vibrator (for example piezoelectric vibrator) of vibrational energy to stop medicine to dose pack or cell-shell.The particulate optics of aerosol or the acoustic sensor of suction apparatus flow duct preferably can be monitored and be quantized to move through to pick off.
Shown in Figure 16 A and 16B, be atomized separated drug 800 jet flows (also can with the medicine of mixed with excipients) and move, shown in arrow 804 and 802 by inhaler flow channel 810.With reference now to Figure 16 A,, optics, acoustics or other physical sensors or the monitor of aerosol 800 through measuring the characteristic of aerosol jet flow 800 and can inferring the medication amount of the flow channel 810 of flowing through.The light source or the sound source 820 that are installed in flow channel 810 are shown, and also are installed in the optics of this flow channel 810 or acoustic monitoring device 830 can be monitored the signal of being launched by source 820 owing to interacting with aerosol 800 decay.The decay of unified signal can be inferred the medication amount of having passed through flow channel 810 with the time of aerosol process flow channel 810.After predetermined close passed through flow channel 810, the driving of piezoelectric actuator (not shown) was stopped and therefore interrupts medicine and sends.Thereby can send the medicine of variable dose.In another embodiment, the reflector (not shown) that installation can reflex to light or sound source 820 with the light or the acoustical signal of decay replaces light or sound monitor 830, and as known in the art, this reflector also can be accepted reflected signal in this embodiment.The decay of unified signal can be inferred the medication amount of having passed through flow channel 810 with the time of aerosol process flow channel 810.
With reference now to Figure 16 B,, the light source 850 that is installed in flow duct 810 outsides is provided, it has fibre-optic light guide or optical fiber or the light guide 840 that enters flow duct 810.The optical signal that leaves optical fiber 840 is decayed by aerosol 800 and is monitored by light detection device 860.The decay of unified signal can be inferred the medication amount of having passed through flow channel 810 with the time of aerosol process flow channel 810.After required dosage passed through flow channel 810, the driving of piezoelectric actuator (not shown) was stopped and therefore interrupts medicine and sends.Thereby can send the medicine of variable dose.
Perhaps, pick off is the pick off that the medication amount in cell-shell or dose pack or the encapsulation is stayed in monitoring, the wherein preferred quartz microbalance sensor of this pick off or piezoelectric transducer or acoustic sensor.In the embodiment, be used for driving and vibrate cell-shell with the piezoelectric element that penetrates medicine also as pick off to monitor the medication amount of staying cell-shell or dose pack by the resonant frequency or the motor machine parameter (for example admittance of piezoelectric actuator) of this piezoelectric actuator of measurement.In another embodiment, acoustic sensor is used as the acoustic characteristic that detects cell-shell or measures the resonance wave that produces and therefore monitor the medication amount of still staying in the cell-shell in this cell-shell.In the another embodiment, pick off is by measuring the optical transmission through dose pack or cell-shell, and the medication amount in dose pack or the cell-shell is stayed in monitoring optically.In case pick off monitors by the aerosol granule of measuring residual drug amount or quantification and moving through flow duct required medication amount is delivered to the patient, pick off sends signal to control circuit and is delivered to the patient to stop medicine so.
With reference now to Figure 17 A-17F,, in another embodiment of the present invention, contains the tube 900 of a large amount of (being multiple dose) medication amount.This can comprise the humidity level of selectable hygroscopic element 920 to absorb moisture and to keep the best in the tube 900.Tube 900 has the outlet that communicates with the quantitative plate 930 and first valve plate 940, these quantitative plate 930 preferred forms comprise the rotatable disc in the little quantitative chamber 960 with identical or different size, these first valve plate, 940 preferred forms be included in tube and quantitatively between the plate localized first rotatable cover allowing to select to be used to fill the chamber number of medicine, thereby allow to select the variable dose of medicine.In this embodiment, first valve plate 940 allows to open towards the chamber of the selected quantity that is used to fill medicine from tube 900.Second valve plate 950 is between the resonator cavity of quantitatively plate and inhaler, and its preferred form is to comprise second rotatable disc, and medicine is sent and used vibrator mechanisms or piezoelectric element to carry out so that medicine is vaporific scatters and sent from this resonator cavity.During use, first valve plate 940 is opened so that select and is counted corresponding to the specific microcavity 960 of desired amount.Fill selected chamber from tube 900 then, schematically illustrated as arrow 970.First valve 940 cuts out and second valve 950 is opened to allow medicine to be transferred to that the resonator cavity (not shown) is used for atomizing and be delivered to the patient by penetrating from resonator cavity then, and is schematically illustrated as arrow 980, for example sprays by synthetic.Figure 17 B-17C illustrates the quantitative plate 930 of closing respectively, opens to be used for powder filler 910, and opens and be used to discharge powder 910.Figure 17 E and 17F are the plan view from above of quantitative plate 930, are illustrated in first valve plate 940 and open the variable dose of selecting drug powder 910 by the variable number of selecting little dosing chamber 960.
In the embodiment more of the present invention, provide and inhaler 10 shown in Figure 1 or inhaler shown in Figure 4 100 similar inhalers, just this inhaler has only a vibrating mechanism 36 or 37 or 104 or 106.Estimate from single cartridge case 34 that is coupled to vibrating mechanism or 35 dosage delivered from Delivery time and suitable calibration curve, wherein, are proofreaied and correct the cartridge case 34 of drug pack or cell-shell or 35 vibration or Piezoelectric Driving time by dosage delivered.This after embodiment in, will need dosage to send by control medicine Delivery time or the time that more specifically vibrator mechanisms or piezoelectric element is contacted with drug pack be activated by control or load cycle.In this embodiment, all medication amount that contain in perhaps single drug pack or the cell-shell are sent with maximal dose, and the part medication amount that contains in perhaps single drug pack or the cell-shell is sent as the more low dosage of medicine.Turn off vibrating elements by before the whole dosage that contains in the single drug pack is sent, the variable dose medicine can be delivered to the patient.Perhaps, variable drug dose can be by with more low-yield input operation vibrating elements, causes lower vibratory drive and is delivered to the patient, perhaps by with lower load cycle operation vibrating elements, switches opening and closing of output discontinuously and is delivered to the patient.
Above-mentioned embodiment of the present invention only is a possible example in implementing, and it proposes only in order to be expressly understood principle of the present invention.Can carry out many changes or modification to above-mentioned embodiment of the present invention and do not deviate from spirit of the present invention and principle in fact.All modifications herein or change one's intention comprises in this open text and the scope of the present invention and by following claim to be protected.
Claims (54)
1, a kind of suction apparatus to patient's delivering therapeutic agents, it is characterized in that, described therapeutic agent is assembled to be delivered to the patient by the vibrator depolymerization and in air-flow, wherein said device comprises at least two vibrators, and described vibrator optionally joins to produce the desired amount of described therapeutic agent with two or more described therapeutic agent couplings that contain identical or different dosage amount.
2, suction apparatus according to claim 1 is characterized in that, described at least two vibrators are with identical frequency and/or amplitude vibrations.
3, suction apparatus according to claim 1 is characterized in that, described at least two vibrators are with different frequencies and/or amplitude vibrations.
4, suction apparatus according to claim 1 is characterized in that, described at least two vibrators comprise piezoelectric vibrator.
5, suction apparatus according to claim 1 is characterized in that, described at least two vibrators comprise the barrier film that static drives.
6, suction apparatus according to claim 1 is characterized in that, described therapeutic agent is the form of dry powder or the form of liquid.
7, suction apparatus according to claim 1 is characterized in that, described dose pack comprises and contains the blister packs of the described therapeutic agent of measuring amount.
8, suction apparatus according to claim 7 is characterized in that, carries a plurality of described blister packs on band.
9, suction apparatus according to claim 1 is characterized in that, described dose pack comprises single dose pack.
10, suction apparatus according to claim 1 is characterized in that, described dose pack comprises two or more dose pack of various dose size.
11, suction apparatus according to claim 10 is characterized in that, described dose pack comprises the dosage size that is selected from the group of being made up of 1,2,3,4 and 5 dosage unit.
12, suction apparatus according to claim 11, it is characterized in that, described therapeutic agent comprises that insulin and described dose pack comprise the insulin of the insulin of the insulin of the insulin of 1 unit dose encapsulation, 2 unit dose encapsulation, 3 unit dose encapsulation, 4 unit dose encapsulation and the insulin of 5 unit dose encapsulation.
13, a kind ofly send the suction apparatus of one or more therapeutic agents to the patient, described device provides chooses at least two dose pack to produce the desired amount of described one or more therapeutic agents when once sucking.
14, suction apparatus according to claim 18 is characterized in that, described dose pack is simultaneously or in a sequence sent.
15, a kind of suction apparatus comprises:
Resonator cavity,
Be coupled to the vibrator in described chamber,
A plurality of drug pack that contain therapeutic agent, described drug pack are arranged in the carrier winding,
Wherein from the described therapeutic agent of one or more described drug pack be deposited over described resonator cavity with the desired amount that produces described therapeutic agent and
The vibration of wherein said vibrator causes described therapeutic agent to be atomized to scatter and penetrates from described resonator cavity, and sends described therapeutic agent when once sucking.
16, suction apparatus according to claim 15 is characterized in that, described therapeutic agent is the form of dry powder or the form of liquid.
17, suction apparatus according to claim 15 is characterized in that, described drug pack comprises and contains the blister packs of the described therapeutic agent of measuring amount.
18, suction apparatus according to claim 15 is characterized in that, described drug pack comprises single dose pack.
19, suction apparatus according to claim 15 is characterized in that, described drug pack comprises two or more dose pack of various dose size.
20, suction apparatus according to claim 19 is characterized in that, described drug pack comprises the dosage size that is selected from the group of being made up of 1,2,3,4 and 5 dosage unit.
21, suction apparatus according to claim 20, it is characterized in that, described therapeutic agent comprises that insulin and described drug pack comprise the insulin of the insulin of the insulin of the insulin of 1 unit dose encapsulation, 2 unit dose encapsulation, 3 unit dose encapsulation, 4 unit dose encapsulation or the insulin of 5 unit dose encapsulation.
22, a kind of suction apparatus comprises:
A plurality of drug pack that contain therapeutic agent, described drug pack are arranged in the carrier winding,
Vibrator is coupled at least one described drug pack,
Wherein from the described therapeutic agent of one or more described drug pack be atomized when the described vibrator vibration scatter and from described drug pack, penetrate and
Wherein said drug pack advances to be created in the desired amount of the described therapeutic agent of being sent when once sucking in described carrier winding.
23, suction apparatus according to claim 22 is characterized in that, described therapeutic agent is the form of dry powder or the form of liquid.
24, suction apparatus according to claim 22 is characterized in that, described drug pack comprises and contains the blister packs of the described therapeutic agent of measuring amount.
25, suction apparatus according to claim 22 is characterized in that, described drug pack comprises single dose pack.
26, suction apparatus according to claim 22 is characterized in that, described drug pack comprises two or more dose pack of various dose size.
27, suction apparatus according to claim 26 is characterized in that, described drug pack comprises the dosage size that is selected from the group of being made up of 1,2,3,4 and 5 dosage unit.
28, suction apparatus according to claim 27, it is characterized in that, described therapeutic agent comprises that insulin and described drug pack comprise insulin or 5 unit dose encapsulation of the insulin of the insulin of the insulin of 1 unit dose encapsulation, 2 unit dose encapsulation, 3 unit dose encapsulation, 4 unit dose encapsulation.
29, a kind of suction apparatus comprises:
A plurality of drug pack that contain therapeutic agent,
Vibrator is coupled to more than one described drug pack,
Wherein one or more described drug pack be the drug pack that is opened or be pierced and
Wherein be atomized when the described vibrator vibration and scatter and from described that be opened or the drug pack that is pierced, penetrate to be created in the desired amount of the described therapeutic agent of being sent when once sucking from the described therapeutic agent of described that be opened or the drug pack that is pierced.
30, suction apparatus according to claim 29 is characterized in that, described therapeutic agent is the form of dry powder or the form of liquid.
31, suction apparatus according to claim 29 is characterized in that, described drug pack comprises and contains the blister packs of the described therapeutic agent of measuring amount.
32, suction apparatus according to claim 29 is characterized in that, described drug pack comprises single dose pack.
33, suction apparatus according to claim 29 is characterized in that, described drug pack comprises two or more dose pack of various dose size.
34, suction apparatus according to claim 33 is characterized in that, described drug pack comprises the dosage size that is selected from the group of being made up of 1,2,3,4 and 5 dosage unit.
35, suction apparatus according to claim 34, it is characterized in that, described therapeutic agent comprises that insulin and described drug pack comprise the insulin of the insulin of the insulin of the insulin of 1 unit dose encapsulation, 2 unit dose encapsulation, 3 unit dose encapsulation, 4 unit dose encapsulation or the insulin of 5 unit dose encapsulation.
36, a kind of suction apparatus comprises:
At least one contains the drug pack of therapeutic agent,
Vibrator is coupled to described drug pack, and described vibrator is suitable for vibration and makes described therapeutic agent atomizing scatter and penetrate from described drug pack forming aerosol,
Pick off is suitable for measuring the amount of therapeutic agent described in the described aerosol,
Wherein said pick off is provided signal after sending so that the vibration of described vibrator stops at the described therapeutic agent of desired amount when once sucking.
37, suction apparatus according to claim 36 is characterized in that, described therapeutic agent is the form of dry powder or the form of liquid.
38, suction apparatus according to claim 36 is characterized in that, described drug pack comprises and contains the blister packs of the described therapeutic agent of measuring amount.
39, suction apparatus according to claim 36 is characterized in that, described drug pack comprises single dose pack.
40, suction apparatus according to claim 36 is characterized in that, described drug pack comprises two or more dose pack of various dose size.
According to the described suction apparatus of claim 40, it is characterized in that 41, described drug pack comprises the dosage size that is selected from the group of being made up of 1,2,3,4 and 5 dosage unit.
42, according to the described suction apparatus of claim 41, it is characterized in that, described therapeutic agent comprises that insulin and described drug pack comprise the insulin of the insulin of the insulin of the insulin of 1 unit dose encapsulation, 2 unit dose encapsulation, 3 unit dose encapsulation, 4 unit dose encapsulation or the insulin of 5 unit dose encapsulation.
43, suction apparatus according to claim 36 is characterized in that, described pick off is optical pickocff or acoustic sensor.
44, a kind of suction apparatus that is used for to patient's delivering drugs comprises:
Be used to contain the tube of drug powder, have the valve outlet port that is used for described drug powder;
Quantitatively plate has the little quantitative chamber that optionally is communicated with described valve cylinder outlet, and the drug powder of selected amount can be delivered to described plate by described outlet;
Valve plate is optionally operated the described drug powder of selected amount is delivered to the resonator cavity of suction apparatus from described quantitative plate; With
Vibrator is coupled to described resonator cavity and is suitable for vibration and makes the atomizing of described drug powder scatter and penetrate from described resonator cavity.
According to the described suction apparatus of claim 44, it is characterized in that 45, described medicament comprises insulin.
According to the described suction apparatus of claim 44, it is characterized in that 46, described valve plate comprises rotating valve plate.
47, a kind of suction apparatus comprises:
At least one contains the drug pack of therapeutic agent,
Vibrator is coupled to described drug pack,
Pick off is suitable for measuring the amount of therapeutic agent described in the described drug pack,
Wherein be atomized when the described vibrator vibration and scatter and from described drug pack, penetrate being created in the desired amount of the described therapeutic agent of being sent when once sucking from the described therapeutic agent of described drug pack,
Wherein said pick off is provided signal after sending so that the vibration of described vibrator stops at the described therapeutic agent of desired amount when once sucking.
According to the described suction apparatus of claim 47, it is characterized in that 48, described therapeutic agent is the form of dry powder or the form of liquid.
According to the described suction apparatus of claim 47, it is characterized in that 49, described therapeutic agent comprises insulin.
According to the described suction apparatus of claim 47, it is characterized in that 50, described pick off is optical pickocff, acoustic sensor or piezoelectric transducer.
51, a kind of suction apparatus comprises:
At least one contains the drug pack of therapeutic agent,
Vibrator is coupled to described drug pack,
Wherein be atomized when the described vibrator vibration and scatter and from described drug pack, penetrate from the described therapeutic agent of described drug pack,
Wherein said vibration continue for some time with the desired amount that produces described therapeutic agent and
Wherein said vibration stops after described therapeutic agent is sent when once sucking.
According to the described suction apparatus of claim 51, it is characterized in that 52, described therapeutic agent comprises insulin.
53,, comprise the pick off of the amount that is used to detect the described therapeutic agent of being sent according to the described suction apparatus of claim 50.
According to the described suction apparatus of claim 53, it is characterized in that 54, described pick off comprises optical pickocff or acoustic sensor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78929006P | 2006-04-05 | 2006-04-05 | |
| US60/789,290 | 2006-04-05 | ||
| US11/696,683 | 2007-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101489612A true CN101489612A (en) | 2009-07-22 |
Family
ID=40892000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200780012364XA Pending CN101489612A (en) | 2006-04-05 | 2007-04-04 | Variable dose inhalation device |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101489612A (en) |
| ES (1) | ES2360634T3 (en) |
| ZA (1) | ZA200808466B (en) |
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| CN102384778A (en) * | 2011-10-08 | 2012-03-21 | 山东大学 | Inhaled medicine dose detector based on optical waves |
| CN103945885A (en) * | 2011-11-15 | 2014-07-23 | 皇家飞利浦有限公司 | A nebulizer, a control unit for controlling the same and a method of operating a nebulizer |
| CN105381524A (en) * | 2010-01-05 | 2016-03-09 | 微剂量治疗技术公司 | Inhalation device and method |
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- 2007-04-04 ES ES07781365T patent/ES2360634T3/en active Active
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2008
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA200808466B (en) | 2009-12-30 |
| ES2360634T3 (en) | 2011-06-07 |
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