CN101485920B - Laser therapy device - Google Patents
Laser therapy device Download PDFInfo
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- CN101485920B CN101485920B CN 200910105414 CN200910105414A CN101485920B CN 101485920 B CN101485920 B CN 101485920B CN 200910105414 CN200910105414 CN 200910105414 CN 200910105414 A CN200910105414 A CN 200910105414A CN 101485920 B CN101485920 B CN 101485920B
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Abstract
The invention relates to a laser therapy device, which comprises a power supply, a laser, an output power controller, a pulse controller, a light gathering device, an optical fiber processing device and a central control system, wherein the central control system is used for controlling the power supply, the laser, the output power controller and the pulse controller; the power supply is used for supplying power to the laser; the laser is used for generating laser light; the laser light enters the light gathering device through the output power controller and the pulse controller; the laser light is transmitted to the optical fiber processing device after being gathered by the light gathering device; and the optical fiber processing device is used for irradiating the laser light into cells inoculated with light perception genes. The light perception genes are photaesthesia channel genes or pump protein genes. The laser therapy device has cell specificity, and can effectively activate or inhibit the neuron.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, relate in particular to a kind of device for laser therapy.
Background technology
Central nervous system disease refers to the disease that brain and spinal cord etc. cause owing to reasons such as infection, heredity, degeneration, such as epilepsy, parkinson, cerebral palsy of children, major depressive disorder etc., complicated, the serious symptom of the state of an illness often, cause the obvious disability of patient, the forfeiture self care ability brings heavy mental pressure and financial burden for family and society.Therefore the treatment of central nervous system disease attracts wide attention, and is more and more urgent to the Treatment need of this type of nervous system disease.
Traditional Therapeutic Method comprises Drug therapy and damages operation.Drug therapy is the Treatment of Central Nervous System Diseases method of commonly using.The outbreak of epileptics can be controlled and alleviate to antuepileptic, but easily produce drug resistance, and anti-insane spectrum is narrow, and side effect is large.Patient about 20% uses antuepileptic to still have repeatedly outbreak, fails to reach the effect of control epileptics.Parkinsonian Drug therapy adopts alternative medicine more, started new era of parkinson Drug therapy such as levodopa class medicine, but the side effect such as also produced dizzy, vomiting, feel sick, and the motor complications such as symptom fluctuation, unusual fluctuation disease appear in 50% above patient.Drug therapy cerebral palsy of children curative effect is limited, holds time short, and prolonged and repeated application has side effect, still needs further research.Then onset is slow, remission is not thorough, relapse rate is high, still lacks ideal medicament for the medicine of depression.Damaging operation is under the condition that disease is clear and definite in brain, removal of lesions was or damage target spot.But surgical risk is large, and difficulty is high, has certain traumaticly, and irreversible damage often has again unpredictable pernicious consequence, causes case fatality rate and disability rate high.
For the problems referred to above, developed again in recent years deep brain nuclear group's electricity irritation (Deep brain stimulation, DBS) and stimulated (Transcranial Magnetic Stimulation, TMS) two technology through cranium repeatability low-frequency magnetic.The electricity irritation of deep brain nuclear group is to utilize brain stereotactic operation a certain specific position implant electrode in brain, produces pulse by stimulus generator, and group carries out chronic stimulation to brain deep nerve nuclear, thus the dyskinetic disorders such as treatment epilepsy and parkinson.The method is not destroyed cerebral tissue and nervous tissue, is reversible, can adjust stimulus intensity and frequency external, for extensive patients has been brought Gospel.Stimulating through cranium repeatability low-frequency magnetic is a kind of AT electrophysiological technique that neurocyte is stimulated in the brain outside.The action principle that stimulates through cranium repeatability low-frequency magnetic is to produce transient magnetic field with a fast current pulse, skull is passed in this magnetic field, cause that contiguous nervous tissue produces the secondary electric current, the neurocyte depolarization, thereby produce the electrical activity that stimulates or block cerebral tissue, be mainly used in clinically treatment epilepsy, parkinson, major depressive disorder, apoplexy, chronic pain etc.Stimulating through cranium repeatability low-frequency magnetic is a kind of noinvasive, painless, safe new technique, and multiple central nervous system disease is had certain curative effect.The aspect still needs further research but its mechanism of action, stimulus parameter, curative effect are held time etc.
But the deep brain is examined group's electricity irritation and is also had some shortcomings through the stimulation of cranium repeatability low-frequency magnetic, for example:
1. shortage cell-specific.The electricity irritation of deep brain nuclear group can not realize a certain specific cells hypotype is stimulated, and often causes side effect, and because neurogliocyte cicatrization and electrode can be insulated, therapeutical effect can only continue some months by several years.Around can only stimulating brain, the stimulation of cranium repeatability low-frequency magnetic in several cm range, can't stimulate deep nerve unit at all.
2. both all can not realize the purpose of inhibitory neuron.
Summary of the invention
In view of this, be necessary to lack cell-specific and problem that can not inhibitory neuron for the Therapeutic Method of central nervous system disease, a kind of cell-specific and can the neuronic device for laser therapy of establishment of having is provided.
A kind of device for laser therapy comprises power supply, laser instrument, output power device, impulse controller, beam condensing unit, optical fiber treating device and central control system; Described central control system is used for controlling described power supply, described laser instrument, described output power device and described impulse controller; Described power supply is used for to described laser instrument power supply; Described laser instrument is for generation of laser; Described laser enters described beam condensing unit through described output power device and described impulse controller; Described laser transfers to described optical fiber treating device after described beam condensing unit is assembled; Described optical fiber treating device is used for described laser irradiation has been imported the cell of light sensation gene, makes dissimilar light sensation gene only to the photaesthesia of specific wavelength, and described sensitization gene can be photaesthesia channel gene or chlG gene;
Described laser instrument comprises the first laser instrument and second laser, described output power device comprises the first output power device and the second output power device, described impulse controller comprises the first impulse controller and the second impulse controller, described laser comprises the first laser and the second laser, described the first laser instrument is for generation of described the first laser, described second laser is for generation of described the second laser, described central control system controls described the first laser instrument and the second laser timesharing produces described the first laser and described the second laser, described the first laser enters described beam condensing unit through described the first output power device and described the first impulse controller, described the second laser enters described beam condensing unit through described the second output power device and described the second impulse controller, and described central control system is also for the intensity of regulating described the first laser and described the second laser, repetition rate, pulse number and relative time relation;
Described the first laser instrument is to utilize the frequency multiplication of the 946nm spectral line that neodymium-doped yttrium-aluminum garnet sends to produce the blue light that wavelength is 473nm, and adopt three Lithium biborates to carry out intracavity frequency doubling, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～10kHz, and resonator cavity adopts flat-curved cavity;
Preferably, described second laser is to utilize 1064nm that the Nd-doped yttrium vanadate crystal sends and 1342nm spectral line by KTP crystal and frequently produce wavelength to be the gold-tinted of 593.5nm, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～50kHz, 1064nm and 1342nm laser adopt same resonator cavity, use 1342nm film system during the outgoing mirror plated film, make 1064nm reflectance bead 1342nm reflectance;
Described optical fiber treating device is used for shining the described cell that imports the light sensation gene with the laser after the described decomposition again after described laser being decomposed at least two bundles, laser before the described decomposition is by the first fiber-optic transfer, laser after the described decomposition is by the second fiber-optic transfer, described optical fiber treating device comprises optical fiber emanator and optical fiber integrator, described optical fiber emanator and described the first optical fiber be connected the second optical fiber and be connected, described optical fiber integrator is used for the relative position between fixing described the second optical fiber; Described optical fiber integrator is plate, which is provided with at least two apertures, and each aperture is by second optical fiber, and the length of the second optical fiber is adjustable.
Preferably, described optical fiber emanator is spherical, and its surface is provided with a macropore and at least two apertures, and described macropore connects described the first optical fiber, and each aperture connects second optical fiber.
Preferably, described power supply, laser instrument, output power device, impulse controller, central control system and beam condensing unit form pulse generator, the volume range of described pulse generator is 4 cubic centimetres to 72 cubic centimetres, and the volume range of described optical fiber treating device is 4 cubic millimeters to 50 cubic millimeters.
Preferably, also comprise outside program controller, described outside program controller is used for opening or closing pulse generator, regulates laser generation parameter.
Preferably, also comprise record microelectrode and computer, described record microelectrode is used for the potential change of record cell and the potential change of cell is sent to described computer, described computer is tested for the information that is recorded to is analyzed with behavioristics, and the result that will analyze and test is sent to described central control system, described central control system corresponding modify laser generation parameter.
Above-mentioned device for laser therapy shines lesions position by producing laser, and this laser only works to the cell that has imported the light sensation gene, and therefore, this device for laser therapy has cell-specific.In addition, the laser that this device for laser therapy produces is directly to be deep in the skull to shine, thereby can effectively activate or the inhibitory neuron cell.
Description of drawings
Fig. 1 is the schematic diagram of device for laser therapy the first embodiment.
Fig. 2 is the schematic diagram of blue laser.
Fig. 3 is the schematic diagram of Yellow light laser.
Fig. 4 is the schematic diagram of beam condensing unit.
Fig. 5 is the schematic diagram that optical fiber treating device uses at human body.
Fig. 6 is the amplification inclinating view of optical fiber emanator.
Fig. 7 is the amplification inclinating view of optical fiber integrator.
Fig. 8 is the schematic diagram of laser irradiation cell.
Fig. 9 is the neuronic schematic diagram that laser irradiation has imported the light sensation gene.
Figure 10 is the graph of a relation that brings out current potential and laser pulse.
Figure 11 is the schematic diagram of device for laser therapy the second embodiment.
The specific embodiment
Device for laser therapy comprises power supply, laser instrument, output power device, impulse controller, beam condensing unit, optical fiber treating device and central control system; Described central control system is used for controlling described power supply, described laser instrument, described output power device and described impulse controller; Described power supply is used for to described laser instrument power supply; Described laser instrument is for generation of laser; Described laser enters described beam condensing unit through described output power device and described impulse controller; Described laser transfers to described optical fiber treating device after described beam condensing unit is assembled; Described optical fiber treating device is used for described laser is decomposed at least two bundles, and the laser after the described decomposition is used for the cell that irradiation has imported the light sensation gene.This device for laser therapy has cell-specific and energy establishment neuron.
The number of the laser instrument of this device for laser therapy, output power device and impulse controller can be 1,2,3 or more.Below be to describe as an example of 2 situation example.
Fig. 1 is the schematic diagram of device for laser therapy the first embodiment.The device for laser therapy 100 of the first embodiment comprises power supply 10, the first laser instrument 11, the first output power device 12, the first impulse controller 13, second laser 18, the second output power device 23, the second impulse controller 19, beam condensing unit 14, optical fiber treating device 15, outside program controller 20 and central control system 17.Power supply 10 is rechargable power supplies, and for example chargeable lithium cell once charges and can use at least 5 years.The first laser instrument 11 is for generation of the first laser, and second laser 18 is for generation of the second laser.The first laser enters beam condensing unit 14, the second laser through the first output power device 12 and the first impulse controller 13 and enters beam condensing unit 14 through the second output power device 23 and the second impulse controller 19.Central control system 17 is used for control power supply 10, the first laser instrument 11, second laser 18, the first output power device 12, the second output power device 23, the first impulse controller 13 and the second impulse controller 19, thereby realizes any adjusting of intensity, repetition rate, pulse number and the relative time relation of the first laser and the second laser.Under the control of central control system 17, the first laser and the second laser are that timesharing produces, and namely any time only has a kind of laser to enter beam condensing unit 14.The first laser or the second laser transfer to optical fiber treating device 15 by the first optical fiber (not shown) after beam condensing unit 14 is assembled.Optical fiber treating device 15 is decomposed at least two bundle the 3rd laser or the 4th laser with the first laser or the second laser, and every bundle the 3rd laser or the 4th laser are transmitted by second an optical fiber (not shown).This at least two bundle the 3rd laser or the 4th laser are used for lesions position is shone.
The first laser instrument 11 can be blue laser, a kind of wavelength be 473nm blue laser as shown in Figure 2.Utilize the frequency multiplication of the 946nm spectral line that neodymium-doped yttrium-aluminum garnet (Nd:YAG) sends to produce the blue light of 473nm, at this wave band, general three Lithium biborates (LiB3O5 or LBO) that adopt carry out intracavity frequency doubling, transfer Q to realize quasi-continuous output by acousto-optic Q-switching (A-O-Switch), the range of accommodation of pulse recurrence frequency is 1～10kHz.Resonator cavity adopts flat-curved cavity.
The effect of the various instructions (referring to Fig. 1) that central control system 17 is sent is as follows:
1.P11 and P13 makes the output of the first laser instrument 11 adjustable in the 10-50mW scope for the output of control the first laser instrument 11.
2.P21 and P23 makes the output of second laser 18 adjustable in the 10-50mW scope for the output of control second laser 18.
3.P12 be used for the repetition rate of the acousto-optic Q-switching of control the first laser instrument 11.
4.P22 be used for the repetition rate of the acousto-optic Q-switching of control second laser 18.
5.T1 be used for the lighting time interval of control the first laser.
6.T2 be used for the lighting time interval of control the second laser.
In addition, utilize the clock in the central control system 17 can also control the relative time of the luminous and pulse of first, second laser, thereby finally can realize any adjusting of intensity, repetition rate, pulse number and the relative time relation of first, second laser.
Fig. 4 is the schematic diagram of beam condensing unit 14.Beam condensing unit 14 comprises the first plane mirror 301, the second plane mirror 302 and convex lens 303.The first laser enters convex lens 303, the second laser through the first plane mirror 301 and enter convex lens 303 after the second plane mirror 302 and 301 reflection of the first plane mirror.After the first laser or the second laser planoconvex lens 303 are assembled by the first fiber-optic transfer to optical fiber treating device 15.
In use, power supply 10, the first laser instrument 11, the first output power device 12, the first impulse controller 13, second laser 18, the second output power device 23, the second impulse controller 19, central control system 17 and beam condensing unit 14 form pulse generator.The volume range of pulse generator is 4 cubic centimetres to 72 cubic centimetres.Pulse generator is imbedded near the position the clavicle of human body by operation.
In use, outside program controller 20 is equivalent to a remote controller, is used for opening or closing pulse generator, regulates laser generation parameter.
Fig. 5 is the schematic diagram that optical fiber treating device uses at human body.Optical fiber treating device 15 comprises optical fiber emanator 405 and optical fiber integrator 406.Optical fiber emanator 405 is connected be connected two the second optical fiber 407 with the first optical fiber 402.As shown in Figure 6, optical fiber emanator 405 is spherical, and its surface is provided with a macropore 52 and at least two apertures 51, and macropore 52 and at least two apertures 51 are oppositely arranged.Macropore 52 connects the first optical fiber 402, and each aperture 51 connects second optical fiber 407.As shown in Figure 7, optical fiber integrator 406 is used for the relative position between fixing at least two the second optical fiber 407.Optical fiber integrator 406 is plate, which is provided with at least two apertures 61.Each aperture 61 can pass through second optical fiber 407.Like this, many second optical fiber 407 can cover widely target spot.The volume range of optical fiber treating device 15 is 4 cubic millimeters to 50 cubic millimeters, and therefore, optical fiber treating device 15 can be deep in the cortex 408 in the skull 401.
The first optical fiber 402 is encased by the sleeve pipe 403 of diameter 300-500 μ m, sleeve pipe 403 whole heeling-ins are in human epidermal, one end of sleeve pipe 403 connects pulse generator, the other end is fixed on the skull 401 by holder 404 in scalp 400, and passes skull 401 (in advance positional punch) and be deep into cortex 408.The length of the second optical fiber 407 is adjustable, thereby can control the degree of depth that the second optical fiber 407 is deep into cortex 408.
Fig. 8 is the schematic diagram of laser irradiation cell.The scope of 701 expression laser irradiations, 702 expressions have imported the cell of light sensation gene, 703 represent lead-in light sensillary base not because of cell.The light sensation gene can be photaesthesia channel gene or chlG gene, can import in a certain specific cell, tissue or the individuality light sensation gene and great expression by viral vector in the practice.The importing that only is irradiated by light the cell 702 of light sensation gene just can produce electricity and change and comprise excitement or inhibitory action, and all not lead-in light sensillary bases because of cell 703 and do not receive illumination importing the cell 702 of light sensation gene all unaffected.And, a dissimilar light sensation gene photaesthesia to specific wavelength, for example, the gene pairs sensitive to blue light of photoactivation type ionophorous protein, the gene pairs gold-tinted of light inhibition type ionophorous protein is responsive.Because each the 3rd laser beam that disperses or the range of exposures of the 4th laser beam are less, can shine non-specific site on every side, thereby guarantee the accuracy in treatment site.
Fig. 9 is the neuronic schematic diagram that laser irradiation has imported the light sensation gene, and Figure 10 is the graph of a relation that brings out current potential and laser pulse.When laser pulse arrived neuron 801, the dendron 802 of neuron 801 was accepted this photostimulation, and current potential is brought out in neuron 801 one of corresponding generation, brought out current potential and propagated by aixs cylinder 803.As seen from Figure 10, laser pulse 806 one of a correspondence are brought out current potential 805.
Above-mentioned device for laser therapy 100 resolves into the little laser beam of at least two bundles by optical fiber treating device 15 with a branch of large laser beam, and therefore, the area of the lesions position that this device for laser therapy 100 can shine is larger.And the range of exposures of the little laser beam of every bundle is less, can not shine non-specific site on every side, thereby has guaranteed the accuracy of this device for laser therapy 100.In addition, because this device for laser therapy 100 is to be placed in the human body, can carry, therefore, this device for laser therapy 100 is well suited for patient's routine use.
Figure 11 is the schematic diagram of device for laser therapy the second embodiment.The structure of the device for laser therapy 900 of the second embodiment and the device for laser therapy 100 of the first embodiment is basic identical, and its difference is: the device for laser therapy 900 of the second embodiment also comprises record microelectrode 16 and computer 21.Record microelectrode 16 is used for being imbedded in patient's lesions position, be sent to computer 21 with the potential change of record cell and with the potential change of cell, computer 21 is analyzed with behavioristics the information that is recorded to by specific software and is tested, and feedback information is sent to central control system 17 by wireless transmission method, central control system 17 corresponding modify laser generation parameters.The diameter of record microelectrode 16 is about 100 microns, and therefore, record microelectrode 16 can be deep in the cortex 408 in the skull 401.
Because the information that record microelectrode 16 records is to process at computer 21, computer 21 can carry out more senior analyzing and processing to information, and therefore, 900 pairs of research worker of the device for laser therapy of the second embodiment are studied very helpful.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make at least two distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (5)
1. a device for laser therapy is characterized in that: comprise power supply, laser instrument, output power device, impulse controller, beam condensing unit, optical fiber treating device and central control system; Described central control system is used for controlling described power supply, described laser instrument, described output power device and described impulse controller; Described power supply is used for to described laser instrument power supply; Described laser instrument is for generation of laser; Described laser enters described beam condensing unit through described output power device and described impulse controller; Described laser transfers to described optical fiber treating device after described beam condensing unit is assembled; Described optical fiber treating device is used for described laser irradiation has been imported the cell of light sensation gene, makes dissimilar light sensation gene only to the photaesthesia of specific wavelength, and described light sensation gene can be photaesthesia channel gene or chlG gene;
Described laser instrument comprises the first laser instrument and second laser, described output power device comprises the first output power device and the second output power device, described impulse controller comprises the first impulse controller and the second impulse controller, described laser comprises the first laser and the second laser, described the first laser instrument is for generation of described the first laser, described second laser is for generation of described the second laser, described central control system controls described the first laser instrument and the second laser timesharing produces described the first laser and described the second laser, described the first laser enters described beam condensing unit through described the first output power device and described the first impulse controller, described the second laser enters described beam condensing unit through described the second output power device and described the second impulse controller, and described central control system is also for the intensity of regulating described the first laser and described the second laser, repetition rate, pulse number and relative time relation;
Described the first laser instrument is to utilize the frequency multiplication of the 946nm spectral line that neodymium-doped yttrium-aluminum garnet sends to produce the blue light that wavelength is 473nm, and adopt three Lithium biborates to carry out intracavity frequency doubling, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～10kHz, and resonator cavity adopts flat-curved cavity;
Described second laser is to utilize 1064nm that the Nd-doped yttrium vanadate crystal sends and 1342nm spectral line by KTP crystal and frequently produce wavelength to be the gold-tinted of 593.5nm, transfer Q to realize quasi-continuous output by acousto-optic Q-switching, the range of accommodation of pulse recurrence frequency is 1～50kHz, 1064nm and 1342nm laser adopt same resonator cavity, use 1342nm film system during the outgoing mirror plated film, make the 1064nm reflectance less than the 1342nm reflectance;
Described optical fiber treating device is used for shining the described cell that imports the light sensation gene with the laser after the described decomposition again after described laser being decomposed at least two bundles, laser before the described decomposition is by the first fiber-optic transfer, laser after the described decomposition is by the second fiber-optic transfer, described optical fiber treating device comprises optical fiber emanator and optical fiber integrator, described optical fiber emanator and described the first optical fiber be connected the second optical fiber and be connected, described optical fiber integrator is used for the relative position between fixing described the second optical fiber; Described optical fiber integrator is plate, which is provided with at least two apertures, and each aperture is by second optical fiber, and the length of the second optical fiber is adjustable.
2. device for laser therapy according to claim 1 is characterized in that: described optical fiber emanator is for spherical, and its surface is provided with a macropore and at least two apertures, and described macropore connects described the first optical fiber, second optical fiber of each aperture connection.
3. device for laser therapy according to claim 1, it is characterized in that: described power supply, laser instrument, output power device, impulse controller, central control system and beam condensing unit form pulse generator, the volume range of described pulse generator is 4 cubic centimetres to 72 cubic centimetres, and the volume range of described optical fiber treating device is 4 cubic millimeters to 50 cubic millimeters.
4. device for laser therapy according to claim 3 is characterized in that: also comprise outside program controller, described outside program controller is used for opening or closing pulse generator, regulates laser generation parameter.
5. device for laser therapy according to claim 1, it is characterized in that: also comprise record microelectrode and computer, described record microelectrode is used for the potential change of record cell and the potential change of cell is sent to described computer, described computer is tested for the information that is recorded to is analyzed with behavioristics, and the result that will analyze and test is sent to described central control system, described central control system corresponding modify laser generation parameter.
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| CN101693138B (en) * | 2009-09-28 | 2014-10-29 | 深圳先进技术研究院 | Light stimulus system and control method thereof |
| CN102517195A (en) * | 2011-12-27 | 2012-06-27 | 中国科学院深圳先进技术研究院 | Cell secreta production system based on photosensitive gene and cell secreta production method |
| CN106730396A (en) * | 2017-02-26 | 2017-05-31 | 常州亚当生物技术有限公司 | The therapeutic system of senile dementia and Parkinson's, therapeutic room and treatment glasses |
| CN107684668B (en) * | 2017-05-23 | 2020-04-07 | 西安雅泽泰克医疗科技有限公司 | Laser therapeutic apparatus and spinal cord repair method |
| CN109009428A (en) * | 2018-08-02 | 2018-12-18 | 南京生命源医药实业有限公司 | Infrared laser therapeutic device and system |
| CN112688155A (en) * | 2020-12-25 | 2021-04-20 | 武汉奇致激光技术股份有限公司 | Control method and control system for laser light intensity |
| WO2023108485A1 (en) * | 2021-12-15 | 2023-06-22 | 中国科学院深圳先进技术研究院 | Method for regulating heterogeneity of vascular endothelial cells by means of locus coeruleus and peripheral region thereof |
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