CN101473210A - System and method for collecting, storing, processing, transmitting and presenting very low amplitude signals - Google Patents
System and method for collecting, storing, processing, transmitting and presenting very low amplitude signals Download PDFInfo
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Abstract
Methods and apparatus inject noise into a substance, detect the combination of the noise and the signal emitted by the substance, adjust the noise until the combination signal takes on the characteristic of the signal generated by the substance through stochastic resonance, and apply such characteristic signals to responsive chemical, biochemical, or biological systems. The generated signal may be stored, manipulated, and/or transmitted to a remote receiver.
Description
CROSS-REFERENCE TO RELATED PATENT
That present patent application is advocated is that on June 30th, 2004 submitted to, exercise question be " System andMethod for Producing Chemical or Biochemical Signals ", U.S. Provisional Patent Application No.60/593,006 (attorney docket 38547.8010); Submitted on July 27th, 2004, exercise question be " Signal Processing System; Such as forProducing and Manipulating Signal from Chemical or BiochemicalCompound or Samples ", U.S. Provisional Patent Application No.60/591,549 (attorney docket 38547.8011US); Submitted on August 19th, 2004, exercise question be " Transducing Signals and Methods ", U.S. Provisional Patent Application No.60/593,006 (attorney docket 38547.8012US); With submitted on April 21st, 2005, exercise question be " System and Method for Producing Chemical orBiochemical Signals ", U.S. Provisional Patent Application No.60/674, the rights and interests of 083 (attorney docket 38547.8010US).
Technical field
Embodiments of the invention relate to can be by being used for signal transformation or converting the signal that electromagnetic waves is read to, and the method that produces and use such signal.
Background technology
In chemistry and biochemical field one of received example be chemistry or biochemical effect thing (effector) reagent (for example molecule) by such as the various physical-chemistry force of ion, electric charge or diffusive force one class or pass through the splitting of covalency electric charge induction key or formation and with the goal systems reciprocation.These power can involve vibration or the rotating energy pattern in effector molecules reagent or goal systems.
The inevitable outcome of this example is for the requirement of the effector molecules reagent in the targeted environment in effector molecules-goal systems.Yet, do not know or uncomprehending be whether this requirement relevant with the physical presence of effector molecules, or whether it at least may be because the existence of the energy model of the feature of action effect thing aspect some effector function.If effector function to small part can be carried out emulation by some characteristic energy pattern, then might the influence of " simulation " effector molecules reagent in goal systems by some energy model that system is exposed to feature with effector molecules.If like this, naturally the problem that causes is: which kind of effector molecules molecular energy pattern is effective, how they can be transformed into or convert to the form of measurable signal, can and how these signals be used for influencing goal systems? that is some effector function imitation at least of the molecule of goal systems.
These problems are resolved in the patented claim of submitting to recently of owning together 60/593,006 and 60/591,549 (attorney docket 38547-8010 and-8011).The experiment of carrying out in the support of the invention of describing in patented claim shows that some effector function of on goal systems (one of a plurality of biosystems in this example) can be replicated by the electromagnetic wave that time-domain signal produced that goal systems is exposed to by " conversion " effector molecules compound.According to the invention of previous description, time-domain signal is the signal that is produced by shielding environment compound down by record, and quilt is produced to strengthen the level of observing by the ability of the low frequency random occurrence of compound generation to be injected into recording unit noise simultaneously.In the previous invention of describing, the signal of conversion is the compound time-domain signal of the reality of effector molecules compound.
By being exposed to the effector molecules-molecular signal of feature, goal systems do not need physical presence effector molecules reagent to have many important and interesting application with regard to the possibility that reaches the effector molecules molecular function.Not to come treatment of organs, but can reach same effect by the signal that organ is exposed to drug-specific by applying medicine.Make the field in nanometer, might can encourage from the signal characteristic of the concerted effect thing molecule of the pattern of the expectation of assembly and catalysis or promote by in package system, introducing now from the assembly pattern.
Description of drawings
Fig. 1 is the axonometric drawing that waits according to an embodiment of the molecule electromagnetism signaling checkout equipment of one embodiment of the present of invention formation;
Fig. 2 be faraday cup shown in Figure 1 and content thereof amplification, detailed view;
Fig. 3 is the sectional view of the amplification of an attenuated tubes shown in Fig. 1 and 2;
Fig. 4 is the faraday cup shown in Figure 2 and the sectional view of content thereof;
Fig. 5 is the figure of the Electromagnetic Launching detection system of replacement;
Fig. 6 is the figure that is included in the processing unit in the detection system of above figure;
Fig. 7 is the figure for the processing unit of the replacement of the unit of Fig. 6;
Fig. 8 is by the input of the present invention's execution and the process flow diagram of processing;
Fig. 9 shows the high level flow chart of the data stream that is used for histogram of the present invention space guidance method;
Figure 10 be according to of the present invention, be used for the process flow diagram that the span is guided histogrammic algorithm;
Figure 11 is the process flow diagram according to the step of the best time-domain signal of identification of second embodiment of method of the present invention;
Figure 12 is the process flow diagram according to the step of the best time-domain signal of identification of the 3rd embodiment of method of the present invention;
Figure 13 is presented at conversion equipment layout in the typical transition experiment;
Figure 14 is presented at reset coil and the container that uses in the typical transition experiment;
Figure 15 A-15E shows the part (15A) for the time-domain signal that comprises 40% herbicidal compounds, with-70.9dBm (15B) ,-74.8dBm (15C and 15D) and-recording of the noise level of 78.3dBm (15E), from the FFT of the auto-correlation time-domain signal of the sample of 15A;
Figure 15 F is for the auto-correlation mark of the sample of Figure 15 curve map to the noise value of setting;
Figure 16 shows the block diagram that is used to create from the Signal Processing stream of the sample that can be added to biosystem;
Figure 17 shows the block diagram that is used for the electromagnetic wave that the signal that produces from sample generates is applied to patient's suitable system under system of the present invention;
Figure 18 is the process flow diagram that shows an example of the signal Processing rules be used to revise one or more startup waveforms;
Figure 19 A-19D shows the correction of use graphical user interface to spectrum curve figure;
Figure 20 is the block diagram that shows the alternative of the signal that generated and handled by detection system and processing unit of being used to distribute;
Figure 21 is the block diagram that shows the transducer-receiver/transceiver of the compartment system that is used for Figure 20;
Figure 22 is the H type telefault that is used to present system;
Figure 23 is the implantable coil that is used to change sample in an embodiment of the present invention;
Here the title that provides only is for convenience, and it not necessarily influences scope of the present invention or meaning.
Embodiment
1. definition
Unless expression in addition, following term has following definition.
" sample that presents the molecule rotation " is meant can have gas, the sample material of liquid or solid form (except solid metal), and wherein the one or more molecular compounds or the atomic ion of composition or existence present rotation in sample.
" magnetic shielding " is meant the shielding that the magnetoconductivity owing to shielding material reduces, forbids or stops magnetic flux to pass through.
" electromagnetic screen " is meant for example standard faraday electromagnetic screen, or reduces other method of passing through of electromagnetic radiation.
" time-domain signal " or " time series signal " is meant the signal with the transient signal characteristic that changes in time.
" sample source radiation " is meant magnetic flux or the electromagnetic flux emission that causes from the molecular motion such as the such sample of the rotation of molecular dipole magnetic field.
" Gaussian noise " is meant the random noise with Gauss's distribute power." Gaussian noise " is meant the random noise with Gauss's distribute power." static additive white Gaussian " is meant the random Gaussian with predictable following component." construct noise " can comprise log characteristic, and energy is displaced to another spectral regions from a spectral regions, or it can be designed to the random time unit is provided and amplitude remains unchanged.Compare these two the pink even noises of representative with the real random noise that does not have predictable following component." evenly noise " is meant the noise with constant amplitude.
" frequency domain frequency spectrum " is meant the Fourier frequency curve chart of time-domain signal.
" spectrum component " relates to the amount unusual or that repeat in the time-domain signal that can measure in frequency, amplitude and/or phase field.Spectrum component generally is meant the signal that is present in the frequency domain.
" similarly sample " is meant the sample identical with first sample or has the sample of identical with first sample basically sample component for first sample.
" faraday cup " is meant electromagnetic armouring structure, for the electromagnetic radiation of not expecting is provided to the power path on ground, makes the electromagnetic environment peace and quiet thus.
" spectral characteristic mark " be meant based on selected low-frequency range for example DC (direct current) to 1kHz or DC to 8kHz, the number of the spectrum peak that the reagent of observing in the time-domain signal for reagent or sample record is specific and/or the mark of amplitude, this reagent or sample are by processed such as the proper method of one of three methods described herein, so that disclose reagent or the distinctive discernible spectral characteristic of sample.
" time-domain signal that optimized reagent is specific " is meant to have maximum or near the time-domain signal of maximum spectrum characteristic mark.
II.
Be used to produce and handle the suitable equipment of time-domain signal
Detailed hereafter is used to detect, handle and present the low frequency electromagnetic radiation or the signal of interested sample.In one embodiment, known white or Gaussian noise signal are introduced in sample.Gaussian noise is configured to make the electromagnetic radiation from sample to be enough to be detected by signal detection system.The signal that many groups detect is processed together, to guarantee repeatability and statistic correlation.The radiation pattern or the frequency spectrum that finally obtain can be shown, store and/or be identified as concrete material.
Some embodiments of the present invention have been described with being used for producing signal that the specific electromagnetic converting system of compound that can act on the goal systems that is placed on electromagnetic wave field uses and the method that produces such signal.Other embodiment relates to generation and distributes such signal.
The following description is provided for well understanding and enable to illustrate the concrete details of embodiments of the invention.Yet, it will be apparent to those skilled in the art that the present invention can be implemented without these concrete details.In other example, at length show or describe the 26S Proteasome Structure and Function of knowing, to avoid unnecessarily having blured description to embodiments of the invention.
As what explain below, embodiments of the invention are at the equipment and the method that are provided for repeatedly detecting and writing down low threshold value molecule electromagnetic signal, long-range use after being used for.The faraday cup shielding shielding sample material and the checkout equipment of magnetic shielding are not influenced by external electromagnetic signal.In the faraday cup of magnetic shielding, coil injects white or Gaussian noise, and the non iron pallet is contained sample, and gradiometer detects low threshold value molecule electromagnetic signal.Equipment also comprises superconducting quantum interference device (" SQUID ") and prime amplifier.
Equipment is used by sample being placed in the faraday cup near the magnetic shielding of noise coil and gradiometer.White noise is injected into the noise coil, and modulated, until the molecule electromagnetic signal by till resonance is enhanced at random.The molecule electromagnetic signal of the enhancing by the shielding of faraday cup and external signal and detected and measure by gradiometer and SQUID then by the field that the noise coil generates.Signal is exaggerated and is sent to any suitable record or measuring equipment then.
With reference to Fig. 1, display screen shield structure 10 on the figure, it comprises, arrives the direction of the inside from the outside, lead cage 16, it provides magnetic shielding and inner lead cage 18 and 20 of electromagnetic screen.In another embodiment, the outside is deposited the field and is formed by the solid aluminum sheet material material with alumel outer cover, and electromagnetic screen is provided by two interior wall structures, and each is formed by solid aluminum.
With reference to Fig. 2, faraday cup 10 is open at the place, top, and comprises areole 12 and 14.Faraday cup 10 also comprises three copper mesh cages 16,18 and 20, mutually intussusception.Each copper mesh cage 16,18 and 20 is isolated with other cage by the dielectric barrier (not shown) between each cage.
Areole 12 and 14 also comprises attenuated tubes 22 and 24, and the inside that is linked into faraday cup 10 is provided, and simultaneously the inside of cage and external interference source is kept apart.With reference to Fig. 3, attenuated tubes 24 comprises three copper mesh pipelines 26,28 and 30, mutually intussusception.Outside copper mesh cage 16,18 and 20, each is electrically connected to a copper mesh pipeline 26,28 and 30 respectively.Attenuated tubes 24 is also with there being the cap 32 of perforate 34 to cover.Attenuated tubes 22 comprises copper mesh pipeline 26,28 and 30 equally, but does not comprise cap 32.
Refer again to Fig. 2, low-density non iron sample pallet 50 is placed on faraday cup 10 the insides.Sample pallet 50 is installed into makes it to unload from faraday cup 10 by attenuated tubes 11 and side-wall hole 12.Three clubs 52, each length is attached to sample pallet 50 greater than the distance from the central vertical shaft of faraday cup 10 to the outermost edge of attenuated tubes 11.Three clubs 52 are applicable to the inner curve of deferring to attenuated tubes 22, and like this, sample pallet 50 can be by being supported on club in the attenuated tubes, and are placed on the center of faraday cup 10.In illustrative embodiment, sample pallet 50 and club 52 are made by glass-epoxy.Those skilled in the art will see easily that sample pallet 50 and club 52 can be made by other nonferrous material, and pallet can install by means of other, such as being installed in the faraday cup 10 by means of single club.
Refer again to Fig. 2, cryogenic Dewar bottle 100 is installed in the faraday cup 10 and on sample pallet 50.In disclosed embodiment, Dewar flask 100 is adjusted in the perforate at the top that is fitted to faraday cup 10, and it is by Tristan Technologies, the model BMD-6 liquid helium Dewar bottle that Inc. makes.Dewar flask 100 is made by the glass-epoxy compound.Gradiometer 110 with very narrow visual field suitably is installed in the Dewar flask 100, so that its visual field comprises sample pallet 50.In the illustrated embodiment, gradiometer 110 is the axial magnetic test coils of single order, 1 centimetre of diameter nominal value, and 2% balance, it is to be made by semiconductor.Gradiometer can be any type of gradiometer that comprises the plane gradient meter.Gradiometer 110 is connected to the input coil of a low temperature DC superconducting quantum interference device (" SQUID ") 120.In the disclosed embodiment.SQUID is by Tristan Technologies, the model LSQ/10LTS dc SQUID that Inc. makes.It will be apparent to those skilled in the art that and to use high temperature or exchange SQUID, and do not deviate from the spirit and scope of the present invention.In alternative embodiment, SQUID120 comprises noise suppressing coil 124.
The disclosed combination of gradiometer 110 and SQUID 120 has the sensitivity of 5 little Tesla/ √ Hz when measuring magnetic field.
The output terminal of SQUID 120 is connected to the Technologies by Tristan, the model SP cryocable 130 that Inc. makes.Cable 130 can bear in Dewar flask 100 and not have the temperature of Dewar flask, and signal is sent to the flow locking ring 140 of the outside that is installed in faraday cup 10 and Dewar flask 100 from SQUI 120.Flow locking ring 140 is by Tristan Technologies in the disclosed embodiment, the model iFL-301-L flow locking ring that Inc. makes.
With reference to Fig. 1, flow locking ring 140 further amplifies the signal that receives from SQUID 120, and outputs to iMC-303 iMAG via high level output circuit 142
SQUID controller 150.Flow locking ring 140 also connects optical cable 144 via six meters Optical Fiber Composite of model C C-60 and is connected to SQUID controller 150.Optical Fiber Composite connects optical cable 144 and SQUID controller 150 is by Tristan Technologies, and Inc. makes.Controller 150 is installed in the outside of magnetic shielding cage 40.Optical Fiber Composite connects optical cable 144 control signal is carried to flow locking ring 140 from SQUID controller 150, and the signal that further reduces to measure is subjected to the possibility of electromagnetic interference (EMI).Those skilled in the art it will be appreciated that can use other flow locking ring, connect optical cable and SQUID controller, and does not deviate from the spirit and scope of the present invention.
With reference to Fig. 2, when the sample pallet was fully inserted into faraday cup 10, two unit Helmholtz transformers 60 were installed in arbitrary end of sample pallet 50.In the illustrated embodiment, the coil winding 62 and 64 of Helmholtz transformer 60 is designed to work in direct current to the 50kHz scope, has the centre frequency of 25kHz and the self-resonant frequency of 8.8MHz.In the illustrated embodiment, coil winding 62 and 64 is the shape of rectangle normally, and approximate be 8 inches high and 4 inches wide.Can use other Helmholtz coil, but its size and dimension should be to make gradiometer 110 and sample pallet 50 be placed in the magnetic field that is produced by the Helmholtz coil.Each coil winding 62 and 64 is installed on one of two low-density non iron frameworks 66 and 68.Framework 66 is connected with 68 mutual hinges, and is supported by leg 70.Framework 66 and 68 to leg 70, allows the lower vertical motion of framework with respect to Dewar flask 100 in side attachment.The motion of framework allows to regulate the coil winding 62 and 64 of Helmholtz transformer 60, to change the amplitude of the white noise that receives at gradiometer 110 places.Leg 70 is placed on or is exposed to the bottom of faraday cup 10.In the illustrated embodiment, framework 66 and 68 and leg 70 make by glass-epoxy.Can use other the transformer or the device of coil, and not deviate from the spirit and scope of the present invention.
With reference to Fig. 4, show the sectional view of faraday cup and its content on the figure, with the winding 62 of demonstration Helmholtz transformer 60 and the relativeness of Dewar flask and faraday cup 10.Also represent the placement of sample pallet 50 and sample 200 on Fig. 4.
Referring again to Fig. 1, the adjustable white noise generator 80 of amplitude is in the outside of magnetic shielding cage 40, and is electrically connected to Helmholtz transformer 60 via cable 82 by wave filter 90.With reference to Fig. 3, cable 82 passes side opening 12, attenuated tubes 24 and passes cap 32 via perforate 34.Cable 82 is concentric cable, and it comprises that distribution is by inside and outside magnetic shielding 86 and the 88 means of twisted pair copper leads 84 that surround.In one embodiment, lead can be non-magnetic conductive material, such as silver or golden.Inside and outside magnetic shielding 86 and 88 terminates in cap 32 places, stays the Distance Remaining that this crosses over from the cap end to Helmholtz transformer 60 twisted-pair feeder 84, as shown in Figure 1.Inner magnetic shield 86 is electrically connected to faraday cup 16 by cap 32, and external magnetic shielding 88 is electrically connected to magnetic shielding cage 40, as shown in Figure 1.
With reference to Fig. 1, white noise generator 80 can be created on from zero to the frequency spectrum of 100kHz near noise uniformly.In the illustrated embodiment, the noise that wave filter 90 filtering 50kHz are above, but can use other frequency range, and do not deviate from the spirit and scope of the present invention.
With reference to Fig. 1,2 and 3, the sample of material 200 that be measured is placed on sample pallet 50, and sample pallet 50 is placed in the faraday cup 10.In first embodiment, white noise generator 80 is used for injecting white noise by Helmholtz transformer 60.Noise signal produces induced voltage on gradiometer 110.Induced voltage on gradiometer 110 is detected and is exaggerated by SQUID 120 then, is further amplified by flow locking ring 140 and sends to SQUID controller 150 from the output of SQUID, and then send to dual beam oscilloscope 160.Dual beam oscilloscope 160 also is used for showing the signal that is generated by white noise generator 80.
The white noise signal is by the output of change white noise generator 80 with by being conditioned around sample 200 rotation Helmholtz transformers, as shown in Figure 2.The rotation that centers on hinged Helmholtz transformer 60 of framework 66 and 68 changes its phase place with respect to gradiometer 110.The phase change that depends on expectation, framework 66 are connected with 68 hinge and allow winding 62 and 64 to keep parallel to each other and simultaneously around about 30 to 40 degree of sample pallet 50 rotations.Hinge connect also allow winding 62 and 64 rotations many lose to about 60 degree parallel so that change a signal phase that generates by Helmholtz transformer 60 with respect to gradiometer 110.The typical adjusting of phase place also comprises this parallel orientation that loses, and is preferred though other is oriented under some environment, so that hold for example erose sample 200.Noise is applied in and regulates, and becomes compared with the molecule Electromagnetic Launching of managing to detect until noise to surpass till 30 to 35dB.Under this noise level, noise presents the characteristic of molecule electromagnetic signal by the resonance phenomena of knowing at random.When the oscillograph track of the signal that is detected by gradiometer 110 when reflection changes from reflecting directly track from the signal of white noise generator 80, observe the product of detecting at random.In alternative embodiment, signal can be recorded and/or be processed by any equipment of purchase on the market.
In alternative embodiment, the method for detection molecules electromagnetic signal also comprises injects the anti-phase noise of original noise signal 100 that is added to Helmholtz transformer 60 with noise suppressing coil 124 by SQUID 120.Then, the oscillograph track of the signal that is detected by gradiometer 110 when reflection becomes when nonrandom, can observe the product of detecting at random.
Inject howsoever and regulate noise, product can also be determined by observing the increase that spectrum peak when occurs at random.Spectrum peak can be used as rectilinear on the oscillograph 160 or observed as digital value, or observed by other measurement mechanism of knowing.
Embodiments of the invention provide the molecule electromagnetic signal that detects extremely low threshold value without external intervention.These embodiment are also to be provided the output of these signals by various signal record and the easy-to-use form of treatment facility.
Referring now to Fig. 5, show the molecule Electromagnetic Launching detection of above accompanying drawing and the alternative embodiment of disposal system on the figure.System 700 comprises the detecting unit 702 that is coupled to processing unit 704.Though processing unit 704 is shown in the outside of detecting unit 702, the part of processing unit can be in the detecting unit at least.
Be shown in the detecting unit 702 of Fig. 5 with sectional view, comprise a plurality of parts that mutual cover superimposition is concentrated.Sample container or faraday cup 706 are nested in the metal cage 708.706 metal cages 708 of each sample container can be made up of aluminum.Sample container 706 can be maintained at vacuum, and can be controlled to the temperature that presets by temperature.Metal cage 708 is configured to be used as low-pass filter.
One group of parallel heater coil or unit 710 are between sample container 706 and the metal cage 708 and around sample container 706.One or more temperature sensors 711 also are positioned near heating unit 710 and the sample container 706.For example, four temperature sensors can be placed on around the different position of the outside of sample container 706.Heating unit 710 and temperature sensor 711 can be configured to keep certain temperature of sample container 706 the insides.
Around radome 712 are the cold-producing medium layers 716 with G10 insulation.Cold-producing medium can be a liquid helium.Cold-producing medium layer 716 (being also referred to as cryogenic Dewar bottle) is in the working temperature of 4K.Around cold-producing medium layer 716 are exterior shield covers 718.Exterior shield cover 718 is made by nickel alloy, and it is configured to magnetic shielding.The total magnetic shielding amount that is provided by detecting unit 702 is about respectively-100dB along three orthogonal planes of rectangular coordinate system ,-100dB and-120dB.
Various unit described above is by air-gap or the mutual electrical isolation of medium baffle plate (not shown).Should see that also in order to be easy to explanation, these unit do not draw in ratio relative to each other.
Detecting unit 702 is configured to handle solid, liquid or gas sample.In detecting unit 702, can utilize various sample carriage.For example, depend on the size of sample, can utilize bigger sample carriage.As another example, when sample is when air is reacted, the sample carriage can be configured to seal or form the level Hermetic Package around sample.In another example, when sample was gaseous state, sample can be introduced in sample container 706 the insides and without sample carriage 720.For such sample, sample container 706 remains vacuum.The vacuum seal of locating at the top of sample container 706 721 helps to keep vacuum and/or holds sample carriage 720.
Can rearrange sample carriage 720 or rearrange coil 726,728 one or both of by relative coil 722,724 in the emission and the degree of coupling between the coil 722,724, and be changed by relative sample carriage 720 from sample.
With reference to Fig. 6, utilize the processing unit of aspect of the present invention to comprise sample pallet 840, its allows sample 842 to be inserted into faraday cup 844 and Helmholtz coil 846 and from wherein being removed.SQUID/ gradiometer detector module 848 is placed in the cryogenic Dewar bottle 850.Flow locking ring 852 is coupling between SQUID/ gradiometer detector module 848 and the SQUID controller 854.SQUID controller 854 can be the model iMC-303iMAG multichannel controller that is provided by Tristan.
On Fig. 7, the block diagram of another embodiment of display processing unit.Quarter-phase lock-in amplifier 202 first signal (for example is configured to, " x " or noise signal) be provided to coil 726,728, secondary signal (for example, " y " or noise cancellation signal) is provided to the noise cancellation coil of superconducting quantum interference device (SQUID) 206.Amplifier 202 be configured to the locking and without outside reference, it can be a Perkins Elmer model 7265DSP lock-in amplifier.This amplifier is operated in " Virtualization Mode ", and under this pattern, it locks onto the initial baseline frequency, removes reference frequency then, to allow its free-running operation and to lock onto " noise ".
The noise cancellation characteristic of SQUID 206 can turn on and off.When the noise cancellation characteristic was connected, SQUID 206 can offset or cancel the noise component of the injection that comes self-monitoring emission.For noise cancellation is provided, first signal that is added to coil 726,728 is the noise that surpasses 20dB or 35dB compared with the molecule Electromagnetic Launching of managing to detect.Under this level, the noise of injection presents the characteristic of molecule electromagnetic signal by resonance at random.The secondary signal that is added to SQUID 206 is the noise cancellation signal, it and the first signal paraphase, and the amplitude that has is enough to offset the noise (for example, anti-phase with respect to first signal, 180 degree) at the SQUID output.
The output of SQUID 206 is the input that is added to SQUID controller 208.SQUID controller 208 is configured to control the duty of SQUID 206 and further regulates the signal that detects.As an example, SQUID controller 208 can be by Tristan Technologies, the model iMC-303 iMAG multichannel SQUID controller that Inc. makes.
The output of SQUID controller 208 is imported into amplifier 210.Amplifier 210 is configured to be provided at the gain in the 0-100dB scope.When the noise cancellation node is switched at SQUID 206 places, provide the gain of about 20dB.When SQUID 206 does not provide noise cancellation, provide the gain of about 50dB.
Amplifying signal is imported into register or memory storage 212.Register 212 is configured to the amplifying signal of simulation is transformed into digital signal, and the storage digital signal.In one embodiment, every Hz 8600 data points of register 212 storages, and can handle 2.46Mbit/s.As an example, register 212 can be Sony digital audiotape (DAT) register.By using the DAT register, original signal or data set can be sent to the third party, are used to show or by the specific processing of hope.
The digitalized data group that low-pass filter 214 filters self-recorder 212.Low-pass filter 214 is analog filters, and it can be the Butterworth wave filter.Cutoff frequency is about 50kHz.
The output of bandpass filter 216 is the inputs that are added to Fourier transformer processor 218.Fourier transformer processor 218 is configured to being in the data set that the data in time domain group is transformed into frequency domain.Fourier transformer processor 218 is carried out the conversion of fast Fourier transform (FFT) type.
Data set through Fourier transform is input relevant and comparator processor 220.The output of register 212 also is the input of processor 220.Processor 220 is configured to data set and the data set that writes down are in the past carried out relevant, determines threshold value and carries out noise cancellation (when noise cancellation is not provided by SQUID 206).The output of processor 220 is last data sets of frequency spectrum of the molecule low frequency electromagnetic emission of representative sample.
User interface (UI) 222 such as graphical user interface (GUI), also can be connected to wave filter 216 and processor 220 at least, so that the specified signal processing parameter.Wave filter 216, processor 218 and processor 220 can be implemented with hardware, software or firmware.For example, wave filter 216 and processor 218 may be implemented within one or more semi-conductor chips.Processor 220 can be implemented with software in calculation element.
This amplifier is operated in " Virtualization Mode ", and under this pattern, it locks onto the initial baseline frequency, removes reference frequency then, to allow its free-running operation and to lock onto " noise ".Analogue noise generator (it is made by General Radio, real analogue noise generator) need be respectively applied for the 20dB and the 45dB decay of Helmholtz and noise cancellation.
The Helmholtz coil can have about 1 cubic inch light point, has 1/100
ThBalance.In alternative embodiment, the Helmholtz coil can (insert around vertical) vertically, rotatably and move, and from the parallel pie that diffuses into.In one embodiment, SQUID, gradiometer and driving transformer (controller) numerical value that has 1.8,1.5 and 0.3 microhenry respectively.The Helmholtz coil can have the sensitivity in light point every ampere 0.5 Gauss in place.
May need about 10 to 15 microvolts for random response.By injecting noise, system improves the sensitivity of SQUID device.The SQUID device has the sensitivity of about 5femtotesla when not having noise.This system can improve sensitivity 25 to 35dB by injecting noise and using this resonance response at random, and this amount approaches 1500% increase.
Behind the signal that receives and write down from system, computing machine such as mainframe computer, supercomputer or high-performance computer one class carries out pre-service and aftertreatment, be used for pre-service such as utilization by Autosignal (automatic signal) software that Systat Software of Richmond CA makes, and the Flexpro software product carries out aftertreatment.Flexpro is by Dewetron, data (statistics) analysis software of Inc. supply.Following formula or option can be used in Autosignal and Flexpro product.
Be shown in Fig. 8 by the input of system's 100 execution and the process flow diagram of processing.When sample when being interested, carry out at least four input or data run: first data run is at time t
1Do not have sample, second data run is at time t
2Have sample, the 3rd data run is at time t
3Have sample, the 4th data run is at time t
4Do not have sample.The precision of the execution and last (for example, the being correlated with) data set of collecting to improve from the data set of more than one data run.In this four data run, the parameter of system 100 and condition remain constant (for example, temperature, amplification quantity, coil position, noise signal or the like).
At square 300, suitable sample (if or its first or the 4th data run, no specimen) is placed in the system 100.Given sample does not inject noise, is emitted in the Electromagnetic Launching in the DC-50kHz scope, and its amplitude is equal to or less than about 0.001 little Tesla.In order to obtain so low emission, inject additive white Gaussian at square 301.
At square 302, the induced voltage of the emission of coil 722,724 detection representative samples and the noise of injection.Induced voltage comprises the function of the continuous stream of voltage value (amplitude and phase place) as the time of the duration of data run.Therefore data run length can be 2-20 minute, comprises 2-20 minute the magnitude of voltage as the function of time corresponding to the data set of data run.
At square 304, the noise of induction is cancelled when induced voltage is detected.When the noise cancellation characteristic of SQUID106 was turned off, this piece can be omitted.
At square 306, the magnitude of voltage of data set is exaggerated 20-50dB, depends at square 304 noise cancellation whether occurs.At square 308, the data set of amplification carries out analog to digital (A/D) conversion, and is stored in register 212 then.Digitized data set can comprise the data of millions of row.
After the data set that obtains is stored, at square 310, test, whether (for example, whether obtaining at least four data sets) takes place to check at least four data operations for sample.If obtained four data sets,, carried out low-pass filtering then at square 312 for given sample.Otherwise, with next data run initialization (returning square 300).
Behind low-pass filtering (square 312) and the digitized data set of bandpass filtering (square 314), at Fourier transform square 316, data set is transformed into frequency domain.
Then, at square 318, identical data set is relevant mutually in each data point.For example, corresponding to first data set of first data run (for example baseline or environmental noise data operation) with relevant mutually corresponding to the 4th data set of the 4th data run (for example another noise data operation).If the range value of first data set is identical with the range value of the 4th data set on given frequency, then correlation or the number for this given frequency will be 1.0.Alternatively, the scope of correlation can be set between the 0-100.Like this relevant and more also can carrying out for the second and the 3rd data run (for example, sample data is moved).Because the data set that obtains is stored, they can be after remaining data run be finished afterwards time be access in.
When SQUID 206 did not provide noise cancellation, the predetermined threshold value level can be added to each relevant data set so, to eliminate the irrelevant correlation of statistics.Can use various threshold values, depend on the probable similarity of the sample of the emission spectrum of reality of the length (data run is long more, and the precision of the data of obtaining is big more) of data run and sample and other type.Except threshold level, correlation is averaged.The noise component that the related value of use peace of threshold value causes injecting becomes very little at the relevant data set that finally obtains.
If provide noise cancellation at SQUID 206 places, then the related value of the use of threshold value peace is unnecessary.
In case two sample data groups are finish-machined to relevant sample data group and two noise data groups are finish-machined to relevant noise data group, just from relevant sample data group, deduct relevant noise data group.The data set that finally obtains is final data group (for example, the data set of the emission spectrum of representative sample) (square 320).
Because every Hz can have 8600 data points and final data group can have data point in the frequency range of DC-50kHz, the final data group can comprise several hundred million line data.Each row of data can comprise frequency, amplitude, phase place and correlation.
III.
Produce the method for optimum time-domain signal
According to an aspect of the present invention, have been found that, spectral characteristic relevant with sample in the low frequency time-domain signal that obtains for given sample can be by being recorded in the time-domain signal of sample on the noise level scope, promptly during signal record, be injected into the power gain on the noise in the sample, and be optimised.The signal of record is processed then, disclosing the spectrum signal characteristic, and selects to have the time-domain signal of optimum spectral characteristic mark, as what describe below.Selection optimum or suboptimal time-domain signal is useful, because have been found that according to the present invention, compared with non-optimized time-domain signal, provides intensity more and more predictable response with optimized time-domain signal conversion chemistry or biosystem.On the other hand, the time-domain signal of selecting optimization (or near optimization) is useful when obtaining reliable, detectable sample effect when goal systems is converted with sample signal.
Generally speaking, the scope of the noise level of injection, time-domain signal typically is recorded between 0 to 1 volt on it, typically or alternatively, the noise that injects preferably is in compared with the molecule Electromagnetic Launching of managing to detect and surpasses between 30 to 35dB, for example, and at 70-80-dBm.The number of samples that is recorded, that is, noise level number at interval of record time-domain signal can change from 10-100 or more on it, in any case typically and, with enough little interval, so that can discern good Optimal Signals.For example, the power gain of noise generator level can change on 50 20mV intervals.As what see below, when the spectral characteristic mark of the signal that draws during to the curve of the level of the noise that injects, the peak value that enough hour of noise level increment extends is worked as in demonstration figure on several different noise levels.
The present invention's imagination is used to calculate three kinds of diverse ways for the spectral characteristic mark of the time-domain signal that writes down.These three kinds of methods are 1) histogram sampled point method, 2) generate the FFT of autocorrelation signal, and 3) average FFT, every kind of method of three kinds of methods in describing in detail below.
Though describe particularly, it will be appreciated that every kind of method can be carried out under artificial mode, the user estimates the frequency spectrum as the basis of spectral characteristic mark therein, next record is carried out noise level regulate, and determine when and reach the peak value mark; Or every kind of method can carry out under automatic or semi-automatic pattern, and the program by computer drives increases progressively continuously to noise level and/or estimated spectral characteristic mark therein.
A.
Generate the histogram method of spectrum information
Fig. 9 is at the middle-and-high-ranking other data flowchart of histogram method that is used to generate spectrum information.The data (square 2004) of data of obtaining from SQUID (square 2002) or storage are preserved (square 2006) as 16 bit WAV data, and are transformed into double-precision floating point data (square 2008).The data of conversion can be saved (square 2010) or be shown (square 2012) as original waveform.The data of conversion are sent to the algorithm of describing below with reference to Figure 10, also represent with the square 2014 that is labeled as Fourier analysis then.Can show histogram 2016.Alternatively, as what describe below, the data of conversion can be sent to one of two additional devices.
With reference to Figure 10, the main-process stream of histogramming algorithm is to get the time-domain signal of discrete sampling and use Fourier analysis that it is transformed into the frequency domain frequency spectrum, so that further analyze.Time-domain signal is acquired from ADC (analogue-to-digital converters), and is stored in the impact damper, is represented as 2102.This sample is that SampleDuration is long second, and is sampled with a per second SampleRate sample, therefore provides SampleCount (SampleDuration*SampleRate) individual sample.Can be defined as half of SampleRate from the FrequencyRange that signal is resumed, as by the Nyquist regulation.Therefore, if time series signal is sampled with 10000 samples of per second, then FrequencyRange (frequency range) will be that 0Hz is to 5kHz.An operable fourier algorithm is Radix 2 real number fast fourier transform (RFFT), and it has up to 2
16The selectable frequency domain resolution (FFTSize) of 2 power time.The FFTSize that selection equals 8192 has every hertz of at least one spectral sample point so that enough resolution to be provided, as long as FrequencyRange is in or is lower than 8kHz.SampleDuration should long enough, so that SampleCount〉(2*) FFTSize* 10, so that guarantee reliable result.
Because this FFT only is used as in time FFTSize sample, program must be carried out FFT and average result together to sample order ground, frequency spectrum that must be to the end.If select to skip the FFTSize sample for each FFT, then introduce the statistical error of 1/FFTSize^0.5.Yet if select overlapping FFT to import FFTSize half, this error is reduced to 1/ (0.81*2*FFTSize) ^0.5.This error is reduced to 0.0086805556 from 0.0110485435.About the additional information of sum of errors correlation analysis total can reference: Bendat and Piersol, " Engineering Applications of Correlation and SpectralAnalysis ", 1993.
Before carrying out FFT on the given window, can apply data and come to a point that wave filter is avoided because the spectrum leakage that causes is obscured in sampling.This wave filter can be selected in the middle of rectangle (reactive filter), Hamming, Hanning, Bartlett, Blackman and Blackman/Harris.
In illustrative methods, as showing on square 2104, we select 8192 for variable FFTSize, this be our single job time-domain signal number and by the number of the discrete frequency of FFT output.Should be pointed out that FFTSize=8192 is a resolution, or in by the scope of sampling rate regulation the number of sampled point.This variable n that regulation is carried out how many times discrete RF FT (real number FFT) by SampleCount divided by FFTSize*2, the number of FFT sampled point and being set up.For algorithm generates rational result, this number n should be 10 to 20 (though other numerical value also is possible) at least, wherein more may be preferably to get more weak signal.This is meant that for given SampleRate and FFTSize SampleDuration must be a long enough.Counting is initialized to zero from 0 to n count value m, also as showing on square 2104.
Program is at first set up three impact dampers: be used for the impact damper 2108 of FFTSize histogram sampled point, it is accumulated in the count value of each sampled point frequency; The impact damper 2110 that is used for the average power of each frequency sampling point; With the impact damper 2112 that comprises for the FFTSize reproduction copies of each m.
Program is first with histogram and array initialization (square 2113), and 2114, the FFTSize of a wave datum sample is copied in the impact damper 2112, then wave datum is carried out RFFT (square 2115).FFT is by normalization, so that high-amplitude is 1 (square 2116), and determines the average power (square 2117) of all FFTSize sampled points from normalized signal.For each sampled point frequency, the normalized value from the FFT of this frequency is added to each sampled point (square 2118) in the impact damper.
At square 2119, program check then on each sampled point frequency, with respect to power from the average power of above calculating.If power is in certain multiple ε (between 0 and 1) of average power, then it is counted and the sampled point expected is incremented in histogram buffer device 16.Otherwise, just abandon it.
Should be pointed out that the average power that it compares is only used for this FFT example.Though the slower algorithm that strengthens can be got the path of two deal with data, and calculate temporal mean value all before the histogram level is set.Relatively help to provide for a performance number that frequency sampling point is enough big with ε.More broadly, utilize the formula of ε to help to answer a question, " at this moment on this frequency, signal being arranged? " if answer to being, then it be following the two one of: 1) static noise, its value dropped on this sampled point in this time, or 2) real low-level period signal, almost each time occurs for it.Therefore, histogram counters will be removed the noise bump, to strengthen the low level signal bump.So average and ε multiple allows to select the minimal power level to think important.
Count value m increases progressively at square 2120, and above process repeats for every n group of WAV data, till m is for n (square 2121).In each circulation, 2118, the average power for each sampled point is added to relevant sampled point, and when when 2114 power magnitude condition satisfies, each histogram sampled point is incremented 1.
When considering the data in n all cycles, in the average power of the average power on each sampled point by the total accumulation of handle on each sampled point divided by n, the sum in cycle (square 2122) and shown result's (square 2123), and be determined.Except wherein having construct noise, DC=0 or be in the multiple of 60Hz for example, the average power on each sampled point will more or less be relatively low number.
The value of setting relevant in this method is the numerical value of noise gain and ε.This numerical value decision will be used for distinguishing the power of the incident on the mean value.When 1 numerical value, will not detect incident, because power never surpasses average power.Be tending towards at 0 o'clock at ε, virtually, each numerical value will be placed on the sampled point.Between 0 and 1, promptly typically during the number of the sampled point count value between the about 20-50% that is given in total sampled point count value for construct noise, ε will have maximum " spectral characteristic ", and the meaning is that the resonance incident will definitely be better than pure noise at random.
Therefore, can increase power gain to noise input system ground, 50 millivolts of increments between 0 and 1 volt for example, and at each power settings adjusting ε, till the histogram of observing the peak value with sharp outline.Represent at for example processed sample under the occasion of 20 second time period, will be about 25 seconds for total processing time of each different power and ε.When observing the signal of sharp outline, power settings or ε or the two can be modified, and till producing best histogram, mean the discernible peak value with maximum number.
Under this algorithm, many sampled points can be filled, and relevant histogram presents low frequency, because noise (such as neighbourhood noise) appears at low frequency usually.Therefore, the sampled point that is lower than given frequency (for example, being lower than 1kHz) can be ignored by system, and still presents the enough sampled point numerical value of high frequency, to determine the signal signature of the uniqueness between sample.
Alternatively, because the purposes of ε variable is to be contained in definite different average power level of each cycle, program itself can be regulated ε automatically by using the predetermined function that the optimum value of average power level and ε is interrelated.
Similarly, program is the peak height when each power settings relatively, and regulates the noise power value of setting automatically, until till observing best peak height or characteristic on the histogram.
Though the numerical value of ε can be fixed numeric values for all frequencies, also plan to utilize the numerical value that depends on frequency for ε, so that regulate for low frequency, DC to 1000 for example may observed higher the average energy value.The ε multiple that depends on frequency for example can be by average maximum number low frequency FFT zone and determining be used for a mean value " adjusting " to being determined with numerical value at the ε of the observed numerical value that those are compared of higher frequency.
B.
The FFT of autocorrelation signal
In the second kind of universal method that is used for determining the spectral characteristic mark, the time-domain signal that writes down on the noise of selecting carries out auto-correlation, and the fast Fourier transform (FFT) of autocorrelation signal is used to generate spectral characteristic graph, that is, and and the curve map of signal in frequency domain.FFT is used to calculate then on the frequency range of selecting, and for example DC goes up the mark of a plurality of spectrum signals that surpass average noise level to 8kHz to 1kHz or DC.
Figure 11 is the process flow diagram of the step carried out when the mark of the time-domain signal that calculates record according to this second embodiment.Time-domain signal is sampled as described above, digitizing and filtering (square 402), and the gain of noise level is set to initial level, as 404.408, the typical time-domain signal 402 that is used for sample compound uses the standard auto-correlation algorithm to carry out auto-correlation, and 410, uses the standard fft algorithm to generate the FFT of autocorrelation function.
412, on statistics, the FFT curve map is calculated mark by counting, and, calculate mark 414 greater than the number of the spectrum peak of observed average noise in autocorrelative FFT.This processing procedure repeats by step 416 and 406, till the peak value mark is recorded, that is, begins along with increasing noise gain till reducing until the mark for given signal.418, record peak value mark, then, program or user are from selecting the signal (square 420) corresponding to the peak value mark the file of 422 o'clock time-domain signal.
As mentioned above, this embodiment can carry out in artificial mode, and wherein the user incrementally regulates the noise value of setting with manual mode, from FFT spectrum curve figure manual analysis (counting peak value), and uses the peak value mark to discern one or more best time-domain signals.Replacedly, one or more aspects of described step can robotization.
C.
Ask average FFT
At another embodiment that is used for determining the spectrum peak mark, many under each noise gain, for example the FFT of 10-20 time-domain signal is asked on average, produces the spectrum peak curve map, and calculates mark as described above.
Figure 12 is the process flow diagram of the step carried out when the mark of the time-domain signal that calculates record according to this 3rd embodiment.Time-domain signal is sampled as described above, digitizing and filtering (square 424), and the yield value on noise level is set to original levels, as 426.428, program is created under each noise gain then for a series of FFT of time-domain signal, then 430, these curve maps is asked average.By using the FFT curve map after average, counting on the statistics greater than the FFT after average in observed average noise spectrum peak number and carry out fractional computation, as 432,434.This processing procedure repeats by 436 and 437 logical block, till the peak value mark is recorded, that is, begins along with increasing noise gain till reducing until the mark for given signal.438, record peak value mark, then, program or user are from selecting the signal (square 440) corresponding to the peak value mark the file of 422 o'clock time-domain signal.
As mentioned above, this embodiment can carry out at artificial, semi-automatic or fully automatic mode.
IV.
Form switching signal
The signal that is used for various therapeutical uses or is used to influence biosystem in addition can be directly be generated from the time-domain signal of handling.Signal also can be formed by the signal that structure has a crest frequency of specific identification.For example, system can utilize " activity sexual intercourse ", therein molecular signal characteristic, for example the characteristic peaks frequency of compound, relate to chemical activity, be similar to the structure activity relation of in traditional drug design, using for the reality of compound.In general an application, the activity sexual intercourse is used to drug screening, follows following method in an example.
At first, identification has one or more compound of the activity of expectation, for example, can produce the compound of the response of expectation in biosystem.System log (SYSLOG) is for the time series signal of one of these compounds, and waveform is processed or be optimised, so that identification is for the low frequency peak value of this compound.(in this example " low frequency " relates to the peak value that is in or is lower than 10kHz.) these steps repeat for each compound of the relevant compound of one group of structure.The relevant compound of structure comprises those active compounds (producing the response of expectation) and is some nonactive compound for the biological response of test.The spectrum component of two group compounds compares, so that identification those spectrum components relevant uniquely with the compound activity.For example, by analyzing the form from three activity and three non-active compounds, can be identified in those peak values of finding in the reactive compound and do not have the signal of discovery in non-active compound, wherein some hypothesis provides the biological response of expectation.
Similarly, system can write down the compound with any the unknown of optimization.Then, whether the waveform that can finally obtain with the signal analysis relevant with compound known shows the component that the architectural characteristic relevant with desired characteristics is relevant with nonactive component with shortage to check unknown compound, to help the active compound of identification.Concern that from signal structure available rule is compared with concerning available rule from the structure activity, be that more can insert and more predictable, because active can being correlated with, rather than carry out relevant with the structure variable of big figure with the crest frequency of relative less number.Therefore,, can use the existence of some crest frequency or do not exist, have medicine synthetic of improved pharmacokinetics or targeted activity with guiding in order to be used for drug design.For example, if the pharmacokinetic properties of difference or the flanking effect do not expected can carry out relevantly with some crest frequency, then will propose not or reduce the compound of novelty of the amplitude of these frequencies.As a result, system of the present invention simplifies the task of working out useful drug design rule widely, because rule is based on the crest frequency of less relatively number.
Represent the big database of the spectrum peak frequency of chemical compound lot to allow the composite signal characteristic, so that the drug regimen characteristic of synthetic virtually any medicine or expectation.By making up this database and chemical compound database, can generate the chemical constitution of the crest frequency group that shows expectation.This method is similar to current computer assistant chemical synthesis program, and the compound that is used for generating the compound that is used for interested novelty is synthetic.
System can utilize many signal processing technologies, as described herein.For example, from the signal of the relevant compound of two or more structures can with come self-structure relevant but one or more signals inactive or not desired compounds compare so that only be identified in desired frequency component between the signal.Therefore can make up the signal that finally obtains of the peak value that includes only expectation.By generating time-domain signal then, this time-domain signal can be used to therapeutical uses.
Certainly, time-domain signal can be generated from the frequency-region signal of the processing of individualized compound.For example, can obtain being used to expect the frequency-region signal of sample, and produce the wanted signal after handling.Use known technology, the signal after handling can generate time-domain signal, and it can be used to treatment or other purposes then, as the simulation of compound itself.
Figure 15 shows the typical time-domain signal for sample compound, be in this example glyphosate herbicidal (herbicide glyphosphate) (RoundupR).Here the fragment of Xian Shiing is taken as 14.08 to 14.16 seconds time periods.Time-domain signal carries out auto-correlation by use standard auto-correlation algorithm then, and generates the FFT of autocorrelation function by use standard fft algorithm.
Use the FFT curve map,, on statistics, curve map is calculated mark greater than the number of the spectrum peak of observed average noise in autocorrelative FFT by counting such as what show at Figure 15 B-15E.This processing procedure repeats, and till the peak value mark is recorded, that is, begins along with increasing noise gain till reducing until the mark for given signal.Record peak value mark, then, program or user select the signal corresponding to the peak value mark from the file of time-domain signal.
A series of autocorrelative FFT curve maps show the signal analysis that relates in the method on Figure 15 B-15E.On the noise level of 70.9-dBm (Figure 15 B), observe the considerably less peak value (the highest spike is represented 60 recurrent (impulsive) noises) more than ground unrest.(Figure 15 C and 15D) (this represents records different under identical noise level) on the optimum noise level of 74.8-dBm observed at many peak values of adding up on the DC-8kHz scope greater than average noise.Several peak values of these peak values are not too outstanding or disappear under the higher noise gain of 78.3-dBm (Figure 15 E).
When the spectral characteristic mark of these signals is drawn as the function of the noise value of setting, shown in Figure 15 F, observe the peak value mark when noise value of setting of about 75-dBm.From this curve map, select time-domain signal corresponding to a peak value mark.
V.
Conversion equipment and agreement
This section is described equipment and the method that is used for by the conversion of signals sample that forms according to aspect of the present invention, and the various biosystems of general introduction demonstration are for the experiment of the response of time-domain signal of the present invention.The signal that adopts in these experiments is the optimized time-domain signal that the method for as described above forms, and their show the ability that is created in the specific response of compound in the various biosystems according to signal of the present invention.
Figure 13 shows the layout that is used for changing by the reagent specific signal equipment of sample according to embodiments of the invention.Concrete layout contains 5 different samples, comprises being maintained in the reset coil and being exposed on three samples 444,446 and 448 in the electromagnetic signal; Be used as a sample 450 of control; An and sample 452 that is used as chemical co-ordination control.The system of Figure 13 can be used to experiment; If be used to treat patient, then some unit can omit, such as 448,450,452 or the like.
Conversion by the reagent specific signal is carried out to sample by " broadcast " optimization reagent specific signal, and wherein signal is recorded in CD, and is played by prime amplifier 456 and note amplifier on CD register 454.This signal is provided to solenoid 444 and 446 by separated channels, as shown in the figure.In one embodiment, use Sony model C DP CE375 CD Player.The channel 1 of player is connected to the CD input end 1 of Adcom prime amplifier model GFP 750.Channel 2 is connected to the CD input end 2 of Adcom prime amplifier model GFP 750.CD is recorded into from each channel and plays identical signal.Alternatively, CD can be recorded into from each channel and play different signals.Coil in sample 448 mainly is used for producing the white noise field as the control that is used to test.For example, GR analogue noise generator is by being used for the additive white Gaussian of this coil.Alternatively, this coil can be used for playing any switching signal of record in advance via the 2nd Crown amplifier.
Figure 14 shows sample conversion equipment 446, represents such as any sample 444,446 on Figure 13 and 448.Equipment comprises container 468, places electromagnet 470 and various probe, is used to monitor the condition in the container, for example, and temperature.Electromagnet is placed on the base 474, and it comprises annular traditionally ferromagnetic core and wire-wound group.
In one embodiment, coil carries out engineering design and making by American Magnetics, to be provided at the uniform performance between the coil.Each coil comprises #8 wire gauge (awg) square copper cash of 416 circles, enameled wire, about 2 " air-cores.Each coil can produce about 1500 Gausses at 10 peace RMS at the center at 10 volts of RMS under 11Hz, the temperature that is no more than 15 ℃ rises.
During work, the sample for example part of patient or patient body is placed between the core between the coil.Therefore, for example, coil can be the relative two ends at supporting bed, or in the relative both sides of bed, or in the relative both sides of patient's head.Then, in predetermined treatment cycle, for example 1 to several hours, use signal as shown in figure 13 to generate the device drives coil.
Figure 16 is presented at the example that is used to produce and apply the Signal Processing process under the system of the present invention.At square 3102, system receives and writes down time-domain signal from one or more samples in above-mentioned mode.At square 3104, system generates frequency-region signal, handles this signal then, makes desired frequency component and desired frequency component not separate.At square 3106, the frequency-region signal of processing is transformed back to time-domain signal, at square 3108, then time-domain signal is added to biosystem, to generate the result of expectation.
With reference to Figure 18, be used to revise waveform display method 3300 in square 3302 beginning, therein user's waveform of obtaining beginning.For example, the user selects and the recovery expected waveform from data storage device by using the Standard User interfacing.Alternatively, the user can obtain signal during " in real time " inquiry of sample.
At square 3304, the user can make up waveform and another waveform of beginning, and if wish like this, then the user recovers another waveforms at square 3306.Certainly, the user can only revise the waveform of beginning, if desired.
At square 3308, the waveform that the user begins by any technology modification that uses various technology.Figure 19 C shows an example.Wherein the user only utilizes such as one or more frequency peak in the waveform that the such Standard User interfacing of mouse is handled pointer 3404 and decay (or amplification) begins, as what show on display device.For example, the user can only click the peak value 3402 of the display part of waveform, and uses mouse to spur peak value downwards, to decay its amplitude, shown in Figure 19 D.
Can utilize many other technology.The user can only select the part of waveform, cuts or duplicates it, then it is pasted on the waveform of beginning.For example, with reference to Figure 19 A, the user can be near the part of waveform moving cursor, with the waveform (shown in the dotted line of square 3406) of selecting this part.In case selected, the user just can select from one of several menus, such as cut this part from waveform.Alternatively, in case selected, the user just can revise this portion waveshape, such as by replacing it with smooth line, decays it, amplifies it, or carries out various other signal processing technologies.
System can utilize waveform library, and they can being inserted into or being utilized by user expectation like that.The user can select the part of signal, and makes the peak value that its filtering is all, thus, eliminates noise or desired frequency component not in waveform.For example, Figure 19 B shows the waveform can be stored in the thesaurus or the example of filtering signal 3408.By signal 3408 being applied to the waveform of Figure 19 A, system provides the waveform of the processing that finally obtains, shown in Figure 19 C.
System can utilize various mathematical methods to revise the waveform of beginning at square 3308.For example, the waveform of beginning can be combined with the one or more waveforms that recover at square 3306 by using various mathematical methods.The example of such mathematical operation comprises: addition, subtract each other, multiply each other, the convergent-divergent of convolution, simple crosscorrelation, initial waveform (SW) is as nonlinear function of other waveform or the like.
At square 3310, whether subroutine 3300 inquiry users: wishing has more modification for the waveform of beginning.If then the subroutine loop returns, carry out square 3304 to 3308 once more.If not, then at square 3312, the user can store the waveform that finally obtains.The waveform of storage can be used to revise in the future other initial waveform then, is used to result of treatment, or various other reason described herein.
Be to be used to be shaped waveform or below with some example of the supplementary technology of seasonal effect in time series sets of waveforms.
Passive filter: simple electronic filter is based on the combination (or representative of their logical OR programming) of resistance, inductance and electric capacity.These wave filters can be used in before the record, before handling, or before conversion waveform are formed.Various existing software packages or subroutine allow the user to give the electronic filter modeling of response.Such software routines can be under system of the present invention version by the software modeling that uses such electronic filter be utilized to the filter in frequency domain waveform.
Active filter: hardware or software filter also can be implemented by the combination of using passive component and amplifier, create active filter.These wave filters can have high Q value, and need not use inductance and reach resonance.The same with passive filter, have software application or subroutine for the response of modeling active filter, such subroutine here can be utilized to by using one or more active filter model modification waveforms.System of the present invention can utilize similarly existing software routines, realizes the processing and the shaping that describe below with wave filter.
Digital filter: digital filter is the electronic filter (normally linear) with discrete time, and it normally calculates effective by digital and electronic.Digital filter finite impulse response (FIR) typically (FIR) or infinite impulse response (IIR) wave filter, though also have other type, such as the wave filter that is called as the mixed type that blocks infinite impulse response (TIIR) wave filter, they show finite impulse response (FIR), although it is made by the IIR parts.
Digital signal processing: digital signal processing (for example, being performed as calculation procedure) can emulation for example have the comb filter of tapped delay line.Program is selected number with the broach of emulation tapped delay line from the string number value of representation signal.These numbers multiply each other with constant, and added together, cause the output of wave filter.DSP allows a plurality of passbands or a plurality of band gap, only allows the frequency of a group selection basically, makes it become output stage.
Waveform shaping: have many methods of knowing for the shaping waveform, by rise time, duration and the die-away time that changes it, or by using full wave rectifier or pulse-length modulation (as an example) signal change is become sine wave or changes into signal from sine wave in addition.
All devices described herein can be scaled the system that produces greater or lesser size or intensity and be used for various application.For example, if system will be used to treat patient, then can make up and be used to generate the electromagnetic system that is directed to patient with coil.In an example, embed the bench grafting that circular or square Helmholtz coil are arranged therein and receive the time-domain signal that produces from the frequency-region signal of handling.Patient receives the electromagnetic wave that finally obtains then, to respond to by the biological effect of the expectation that is provided by its compound that generates signal for example is provided.
Be used for electromagnetic wave is applied to patient's system with more aiming at yes possible.For example, one or more coils are provided in the little device (such as the helmet or hand-held club).This output unit receives the time-domain signal that produces from the frequency-region signal of expectation, and is as mentioned above all.The electromagnetic wave that finally obtains can be directed into the specific part of patient body via output device, so that produce the effect of expectation in the part of patient's part.
Figure 17 shows the example of such signal output apparatus.Database 3202 storages are from the signal of one or more compounds or sample.Alternatively, signal can be such untreated frequency domain or time-domain signal that generates of as above mentioning.Computing machine 3204 recall signals and it is provided to signal generator 3206.For example, the time-domain signal of the expectation that generates from the frequency-region signal of the processing that produces by specific compound of computer search.Computing machine is provided to signal processor 3206, only amplifying signal to time-domain signal then.Alternatively, the frequency-region signal that computing machine can retrieval process, this signal is transformed into time-domain signal by signal generator.Can be modified by signal modifier 3208 from the signal of signal generator 3206 outputs.Signal modifier can be carried out additional amplification, filtering or the like.In alternative embodiment, computing machine 3204 is carried out necessary signal and is generated modification, and the circuit that separates that therefore is used for signal generator 3206 and signal modifier 3208 can omit.Alternatively, signal generator 3206 or signal modifier 3208 can be omitted.Alternatively, signal generator 3206 or signal modifier 3208 can be eliminated.
Detecting device 702 is from sample 200 picked up signal, and the processed unit 704 of this signal is handled, to produce digital document 1501, for example a .wav file.This document is stored in storage medium 1502 then, and is distributed or be sent to remote computer or other device.Any storage medium above-mentioned can be utilized to carry signal or data file.
Many aspects of the present invention can be implemented with the executable instruction of computing machine, such as by multi-purpose computer, and server computer for example, wireless device, or the subroutine carried out of personal computer.Those skilled in the art it will be appreciated that, the present invention can pass through other communication, data processing, or computer system configurations, comprising: internet device, handheld device (comprising PDA(Personal Digital Assistant)), the honeycomb that can wear computing machine, form of ownership or mobile phone, to processor system, based on microprocessor or programmable consumer electronics device, set-top box, network PC, mini-computer, principal computer, or the like be implemented.In fact, term " computing machine ", " calculation element " and similar term are here used by exchange ground usually, and relate to any above equipment and system and any data processor.
Many aspects of the present invention can or be specifically programmed, dispose or be fabricated to carry out in one or more computing machines data processor executable instruction, that here explain and be implemented at special purpose computer.Aspect of the present invention can also be implemented in distributed computing environment, wherein execute the task or module by the teleprocessing device that is linked such as Local Area Network, the such communication network of wide area network (WAN) or internet, in distributed computing environment, program module can be placed on local and remote memory storage apparatus.
Many aspects of the present invention for example data file can be stored or be distributed in computer-readable medium, the chip (for example, EEPROM semi-conductor chip), nanometer technology storer, biological memory or other data storage medium that comprise computer-readable disk or CD, hardwired or pre-programmed.In fact, computer implemented instructions, data structure, screen display, ripple/signal file and aspect of the present invention under other data can be by the internet or by other network (comprising wireless network), (for example pass through propagation medium by the signal of propagating, electromagnetic wave, sound wave or the like) in the time period, distributed, perhaps they may be provided in any analog or digital network (packet switch, Circuit-switched or other scheme).
Alternatively, the transmitter in signal collection, processing and transmission system 1504 file via suitable cable or electric wire or wirelessly send to network 1506 (for example, internet).File can be sent to computing machine 1512 (once more, wired or wirelessly) then.
File can be transported to remote location via network, such as arriving transducer-receiver 1508.For example, satellite network 1510 can be used for sending file to transducer-receiver 1508.
Transducer-receiver 1508 can be the reference receiver that is used to receive file, and it comprises transducer, is used for the electromagnetic signal of file conversion for being applied in.In one embodiment, implanting transducer-receiver is implanted in patient, health or the structure.Receiver components at transducer-receiver 1508 is under the occasion of wireless receiver, and transducer-receiver can wirelessly receive file via network (or satellite).In alternative embodiment, cell phone or mobile device 1514 receive the file of automatic network and via any known wireless protocols, comprise short-range wireless protocol, such as bluetooth or any IEEE 802.11 agreements or the like, it is relayed to transducer-receiver.
Transducer-transceiver 1516 is similar to transducer-receiver 1508, has sensor 1518.Therefore, transducer-transceiver 1516 not monoenergetic enough similarly receives the file 1501 that sent and its conversion or be applied to biosystem, but also obtains data from sensor 1518, and these data are sent it back system 1500 (for example, via network).
According to Figure 21, the example of transducer-receiver 1508 and transducer-receiver 1516 is provided, it comprises power supply 1530, is used to provide power to equipment.Transducer-transceiver 1532 receives file 1501 wired or wirelessly, and this document can be converted or be applied to object or sample via transducer 1534 then.File can be amplified and/or handled by processor 1538 by amplifier 1536.Storer 1540 can storage file, or the data that obtain from one or more optional sensors 1518 of storage.
Figure 22 and 23 demonstrations are applicable to reset coil of the present invention.Transducer 494 on Figure 22 is long spiral pipes (solenoid), for example on length up to several feet.Field inside spiral pipe is parallel to the axle of spiral pipe and is constant in spiral pipe, goes to zero in the field of spiral pipe outside (spiral pipe that is similar to endless).This limited length coil only has basic field uniformly near its center.Therefore, by sample or object being placed on the center of coil, when coil is supplied energy by data file 1501 or MIDS signal, produce basic magnetic field uniformly at the sample place.
By the additional number of turns is added to spiral pipe, the additional number of turns 500 of spiral pipe 496 on Figure 23 for example can add additional field intensity at the end of coil, with the decline of compensation at spiral pipe end coil magnetic field.
For any or additional embodiment.Reset coil can be little implantable ferromagnetic coil, blood vessel dilatation coil for example, the electrode of two relative ends that can be by being attached to coil, by implantable system (as system 1508,1516), or by long-range induction system, wherein electromagnet is placed on patient's the preceding close body surface of chest, and receives switching signal.Send to induction of signal implanted coil then.
As mentioned above, the audio files that system's utilization obtains in the experiment of resonance at random is as input, and the sinusoidal wave frequency of output content, amplitude and phase place.System can utilize software routines, and so-called " peakfinder ", it utilizes other software package again, and such as Octave and Pd, these two is the software platform of open-source and current support.
In addition, can use two environmental variance: PF_TMP, it has defined temp directory; And PF_BASE, the position of its regulation peak value finder file.If PF_BASE is not provided, then peakfinder.sh attempts its (the supposing that it is cited as the absolute path title) of citation inference from it originally.Input file is the stereo sound file, supposes it is standard sample speed with 44100.File layout can be " wav ", " au " or " aiff " of 16,24 or 32 bit-pattern frames.Output file is sinusoidal ascii text file of regulation.For example:
| 595 | 100.095749 | 0.095624 | -0.091218 | -0.028693 |
| 1487 | 250.155258 | 0.100177 | 0.040727 | 0.091524 |
Here, first field is a frequency, in first-harmonic analysis frequency unit, illustrate that as following second field is a frequency, in Hz, the 3rd field is sinusoidal wave peak amplitude, in sound import file natural unit, and the 4th and the 5th field is the amplitude of sinusoidal wave cosine and sinusoidal component, the real part of complex amplitude and imaginary part.Yes derives from real part and imaginary part component for amplitude.First field does not have physical significance, and it is intended for use diagnostic uses.
Be used for determining that in the amplitude of the single sine wave of white noise and the technology of frequency be maximum probability (ML) method, it has expanded to a plurality of sine waves.The sinusoidal wave number of this method hypothesis is in advance known.The problem of finding out the sine wave of non-predetermined number is more unmanageable on the mathematics, but it can be processed by supposing the sine wave of being mentioned suitably to be separated on frequency.And, need a kind of method whether to distinguish sinusoidal wave existence.
Following analysis is single sine wave from consider white noise, enters the problem of a plurality of sine waves and non-white (for example, pink) noise then.Given measuring-signal:
x[n]，n＝0，...，N，
(discrete time) not normalized Fourier transform is defined as:
Wherein k is a frequency, in the unit of the fundamental frequency analyzed; 2 π/N is the radian of each sample.K needs not be integer; In fact, when zero filled signal in order needs, can insert the bonus values of k.Have single sine wave by hypothesis, its most probable frequency is given:
k＝argmax|FT{x[n]}(k)|。
In other words, best valuation only is the amplitude of its Fourier transform k value when being maximum.
Then, system determines that whether the valuation of k is corresponding to real sine wave or just corresponding to random fluctuation.For this reason, analyze empty hypothesis, to determine x[n] whether only comprise white noise, for example, its average is 0, the RMS amplitude is σ.Fourier transform at each some k place be N independent random variables and value, each equals sample x[n] multiply by the plural number of unit amplitude, like this, the average of each point of Fourier transform still is zero, standard deviation is
If the hangover characteristic of each noise sample is put up a good show (for example, it is for Gauss or evenly noise performance), the stochastic variable FT{x[n that then finally obtains] (k), for employed N numerical value (10
6Magnitude), will be to approach very much Gauss.So, surpass greater than about
Probability be very little.
On the other hand, peak amplitude is α, and frequency is that k (has the Fourier transform amplitude of α N/2 in 2 π of common unit/real number value sine wave N).In order to obtain
Size, we only need α to be at least
This method is carried out zero padding (between 2 and 4 multiple, depending on next power of 2) to the audio files of record, and report surpasses the peak value of this amplitude threshold then.Peak value is defined as having bigger amplitude for given k value compared with the neighbours for it, and have k 20 consecutive values amplitude at least half (for one minute sample, about 20 π/N Hz or 1/3
The frequency band of Hz).
If there are several sine waves, the frequency of supposing them is apart from one another by opening greater than about 20 π/N, and then Yi Shang method should solve them dividually; Each sine wave drops to 2/3 π k for the influence of approximate Fourier transform being in away from a peak value k cps on the amplitude.
For the non-characteristic white of comfort noise signal, estimate the spectrum envelope of measured signal.Noise can be assumed to be that (as being local white in the 20 above π/N), the numerical value of σ changes lenitively according to selected frequency range in each narrow frequency range.Another problem is whether noise sample that determine to inject can be deducted from the output of the measurement of experiment.Under such situation, by easily measurable transfer function that these two are interrelated, even it is non-linear, the valuation of transfer function is used for removing much noise from the signal of measuring.This has also improved the sensitivity of method.
As what can see from the above explanation that provides, system allows the user to create can be used to treat the waveform that influences or induce reaction in biosystem.Can obtain from the waveform or the frequency spectrum sequence of two or more compounds generations.Can be combined the then signal of the single combination that produces characteristic of these two signals with two independent signals.For example, if for example two original signals relate to two different compounds with two kinds of different treatment characteristics, the signal of the combination that then finally obtains will have the treatment characteristic of two combination of compounds.Composite signal can be controlled then, is found to be the not desired frequency component relevant with spinoff in biosystem or negative reaction with removal.
Alternatively, if two compounds produce similarly response in biosystem, then two signals that generate from these compounds can compare mutually, with identification and the relevant common frequency component of generation biological effect.Can generate the 3rd signal then, it includes only those frequency components relevant with biological effect.Therefore, for example, the signal of some analgesic of example can compare mutually, to discern common frequency component, generates the signal that finally obtains then, is used for transmission, storage or is applied to biosystem.In fact, system allow to make up not directly the new signal based on the signal that generates from one or more compounds.But system allows to generate the signal that only has peak value on desired frequency, and wherein such peak value has the result of expectation in biosystem.Therefore, so synthetic signal is irrelevant with the compound that exists.
Conclusion
Unless context is requirement significantly, in whole instructions and claims, word " comprises " or the like and to be counted as the open implication that comprises, rather than exclusive or exhaustive meaning; That is to say, be the meaning of " including but not limited to ".Word " coupling " makes land used relate to two or more unit as here, and they are connected directly or are connected by one or more temporary locations.In addition, word " here ", " more than ", the individual character of " following " and similar meaning is meant the application's integral body when being used to the application, rather than the application's any concrete part.Under the occasion of context permission, in above detailed description, use odd number or most terms also can comprise a plurality of respectively or odd number.The word of row in two or more " or " cover all following explanations: in the row any, all in the row, and any combination in the row.
The above detailed description of embodiments of the invention is not planned to be exhaustive or to limit the invention to above disclosed precise forms.Though specific embodiments of the invention or example are used for illustrative purposes above being described, the various within the scope of the invention modifications that are equal to are possible, it will be appreciated that as those skilled in the art.For example, though processing procedure or square present with given order, have the routine of step but alternative embodiment can be carried out with different order, or utilize the system of square, and some processing procedure or square can be deleted, mobile, add, divide again, make up and/or revise.Each these processing procedure or square can be implemented in various mode.In addition, carry out serially though processing procedure or square are shown as in time, these processing procedures or square be executed in parallel alternatively, or can be performed in the different time.
Here the instruction of the present invention that provides can be applied to other system, not necessarily above-mentioned system.The unit of various embodiment described above and action can be made up, so that additional embodiments to be provided.
All above patent and application comprise any other list of references that can enumerate in appended form, be hereby incorporated by reference.Many aspects of the present invention can be modified if necessary, utilize system, function and the notion of above-mentioned various lists of references, and additional embodiments of the present invention is provided.
According to above embodiment part, can make these and other change to the present invention.Though above explanation has elaborated some embodiment of the present invention, and described the optimal mode of imagining, no matter how the content more than in text is at length explained, the present invention can realize in many ways.The details of signal processing system can change aspect the details of its embodiment greatly, and simultaneously still by in disclosed herein present invention resides in.As mentioned above, employed concrete term not will be understood that it is that the hint term is redefined here when describing some characteristic of the present invention or aspect, is limited to of the present invention any concrete feature, characteristic or the aspect relevant with this term.Usually, the term that uses in following claim should not seen as and limit the invention to disclosed specific embodiment in technical specification, unless above detailed description one joint is stipulated such term significantly.Therefore, the scope of reality of the present invention not only comprises the disclosed embodiments, and comprises of the present invention all equivalent way of putting into practice or be implemented under the claim.
Claims (33)
1. equipment that is used for providing molecular signal from sample, this equipment comprises:
(a) signal source that generates to small part from sample;
(b) be used to detect near the device of the Electromagnetic Launching signal sample;
(c) superconducting quantum interference device (SQUID) is electrically connected to the Electromagnetic Launching magnetic test coil, and wherein said SQUID is placed on and is used in subcooled device;
(d) be used for surrounding described signal source and the described device that is used for the device of detection signal with noise, the wherein said device that is used for surrounding with noise generates the resonance at random that enough noises cause sample, so that amplify the sample properties signal;
(e) be used for the device that the described signal source of electromagnetic screen, Electromagnetic Launching magnetic test coil, SQUID and noise device are not subjected to the external electromagnetic radiation interference;
(f) be used to control the device of described SQUID;
(g) be used to observe and store the device that is used for the detected signal of device of detection signal by described;
(h) be used for revising the device of the signal of storage according to user-defined criterion; And
(i) be used for amended signal wireless offer chemistry or biosystem so that cause the device of the effect of this chemistry or biosystem.
2. one kind produces this chemistry or biological reagent to the method for the influence of system in response to chemistry or biological reagent, comprising:
(a) generate a plurality of low frequency time-domain signals by following steps:
(i) sample that comprises described reagent is placed in the container with magnetic shielding and electromagnetic screen, wherein said sample is as the signal source of molecular signal, and wherein said magnetic shielding is in the outside of low-temperature (low temperature) vessel;
(ii) under not existing from the situation of another signal of another signal source with noise with enough generations at random the noise amplitude of resonance be injected in the described sample, wherein said noise has basic amplitude uniformly on a plurality of frequencies;
(iii) be recorded under the situation of the signal that does not have another generation the electromagnetic time domain signal of forming by the sample source radiation that is superimposed upon on the noise that injects described low-temperature (low temperature) vessel; And
If (iv) described sample source radiation is not enough to distinguish with the noise that injects, repeat step (ii)-(iii) on each of a plurality of noise levels in the noise level scope of selecting so, present the characteristic of the signal that produces by described signal source until the signal of stack by resonance at random;
(b) by analyzing the signal that in (a), produces, the frequency of the key property of the described time-domain signal of identification representative;
(c) produce signal by the synthetic response of following steps:
From the identification frequency of sample, select at least one frequency; Or
Combination is discerned the frequency of selecting the frequency from two or more reagent samples; And
(d), and in the reagent response system, produce the signal amplitude of the specific effect of reagent and apply synthetic signal in the time period being enough to by transducer by in the magnetic field that the reagent response system is placed on electromagnetic transducer and the reagent response system is exposed to synthetic response produces signal.
3. method according to claim 2, wherein synthetic response produce the combination that signal is following frequency:
The identification frequency of one or more reagent samples of the chemistry of representative sample or biological effect; Or
Discern the frequency of selecting the frequency from one or more reagent samples of some aspect of the chemistry of representing each reagent sample or biological effect.
4. method according to claim 2, wherein analyze (b) and be implemented by one of following steps:
(i) generate histogram, demonstration is for each the incident sampled point f on the frequency range of selecting in the 8kHz scope at DC, number at each sample point event count, wherein f is used to sample the sampling rate of time-domain signal, distributes to the relevant mark of number of one of histogram and sampled point more than given threshold value; And according to this mark selection time-domain signal;
(ii) time-domain signal is carried out auto-correlation, be created on the FFT (fast fourier transform) of the autocorrelation signal on the frequency range that DC selects in the 8kHz scope, distribute to the relevant mark of number of one of FFT signal and the peak value that surpasses average noise average, and select time-domain signal according to mark; And
(iii) calculate a series of fourier spectras of the time-domain signal on each time period in time period of a plurality of definition on the frequency range of selecting between the 8kHz, fourier spectra is asked average at DC; Distribute to the relevant mark of number that this asks one of FFT signal and the peak value that surpasses average noise average after average, and according to mark selection time-domain signal.
5. method according to claim 2, before being included in and exposing, wherein said electromagnetic transducer is implanted to implantable coil in the biosystem, handheld mobile device or the two, wherein signal is via arriving transducer wired or wirelessly, and wherein wireless signal directly or via satellite transmits.
6. equipment that uses characteristic signals in the frequency range of sample between DC and 10kHz to detect the selected material in the described sample, this equipment comprises:
Be used for described sample is placed on the detector coil next door, to generate the device of the electromagnetic time domain signal of forming by the sample source radiation;
Be used to control time-domain signal,, wherein removed the signal in the frequency component of selecting on the frequency from controlling of described amplification with the device of controlling signal that this signal transformation becomes to amplify;
Be used for the described signal of controlling of filtering, selectively to transmit the device of low-frequency spectral components that is in the frequency range between DC and the 10kHz and (ii) has the characteristic of selected material by (i);
The data set that is used for the low-frequency spectral components of the characteristic that with filtered signal and (i) is in the frequency range between DC and the 10kHz and (ii) has selected material carries out simple crosscorrelation, being created in the device of the frequency domain frequency spectrum of DC in the frequency range of 10KHz, and
Be used for determining whether described frequency domain frequency spectrum comprises the characteristic with selected material, and whether diagnosis exists the device of one or more low-frequency signal components of such material in sample.
7. many aspects that are used to produce chemistry or biological chemical reagent are to the equipment in response to the treatment influence of the system of this reagent, and this equipment comprises:
(i) container adapts to the sample of admitting reagent, and this container has magnetic shielding and electromagnetic screen;
The (ii) noise source of scalable power, each that is used for a plurality of noise levels in selected scope is injected into noise in the container that sample is housed;
(iii) detecting device is used to write down by being superimposed upon and injects the electromagnetic time domain signal that the sample source radiation on the noise is formed;
(iv) storage arrangement is used for being stored in each of a plurality of time-domain signals of writing down under the different injection noise levels;
(v) computing machine is applicable to:
(a) take out the time-domain signal that is stored in the storage arrangement;
(b) spectrogram of the described time-domain signal of generation allows to discern the specific time-domain signal of optimized reagent based on the information on the described spectrogram;
(c) discern the frequency of the described optimized reagent signal specific of representative by analyzing time-domain signal; And
(d) generate response by following steps and produce signal:
From the frequency of being discerned, select at least one frequency; Or
With the frequency selected from the frequency of identification with and other relevant selected combination of frequency of generation biological effect; And
(vi) electromagnetic transducer is used for to be enough in system's generation signal amplitude and time period to the reagent specific effect of the system reagent response system being exposed to synthetic signal.
8. equipment according to claim 7, wherein noise source comprises the Gassian noise generator and the Helmholtz coil of scalable power, its receive from noise generator, up to the noise output signal of selecting in 1 volt the scope.
9. equipment according to claim 7, wherein said container is the attenuated tubes with sample retaining zone, around this regional magnetic shielding cage, and be comprised in the magnetic shielding cage also around this regional faraday cup, described Gaussian noise source comprises Gassian noise generator and Helmholtz coil, this coil is comprised in magnetic shielding cage and the faraday cup, and it receives the noise output signal from noise generator, it is used for removing the static noise component of time correlation signal, also comprise the signal phase inverter, effectively be connected to noise source and SQUID (superconducting quantum interference device), be used to receive Gaussian noise, and will output among the SQUID with respect to being injected into the Gaussian noise that Gaussian noise in the sample is the paraphase form from described noise source.
10. equipment according to claim 7, wherein electromagnetic transducer is the Helmholtz coil, and it has the solenoid of a pair of aligning, forms one and expose platform between them, and described exposure comprises sample is placed in the platform.
11. represent the optimization LF-response of the many aspects of chemistry or bioactive agents to produce signal for one kind, this signal produces by following steps:
(a) generate a plurality of low frequency time-domain signals of reagent by following steps:
(i) with the noise amplitude selected noise is injected into the sample of described reagent, to produce resonance at random;
(ii) write down the electromagnetic time domain signal of forming by the sample source radiation on the noise that is superimposed upon injection; And
If (iii) described sample source radiation is not enough to distinguish with the noise that injects, repeat step (ii)-(iii) on each of a plurality of noise levels in the scope of selecting so;
(b) discern the frequency of the optimized reagent signal specific of representative by analyzing preferred time-domain signal;
(d) produce signal by the synthetic response of following steps:
At least one frequency is provided from the identification frequency of reagent sample; Or
Combination is discerned the frequency of selecting the frequency from two or more reagent samples, the selected aspect of the signal that the frequency representative of wherein selecting is associated with chemistry of expecting or biological effect.
12. signal according to claim 11, wherein said signal is directed into biological targets.
13. signal according to claim 11, wherein said signal is transmitted wirelessly receiver, and wherein said receiver comprises implantable transducer or hand-held calculating or telecommunication apparatus.
14. the data-signal that the data handling system of one or more generations is readable, wherein said data-signal is generated by the method that may further comprise the steps:
(a) chemistry or biological reagent are exposed in the noise signal;
(b) detection noise with since at random the result of resonance by the combination of the signal of reagent emission;
(c) regulate noise till the signal that is generated by reagent is to be enough to can distinguish with noise;
(d) obtain the frequency content of reagent signal;
(e) frequency component of modification reagent signal is to strengthen at least one attribute relevant with signal; And
(f) by following steps predetermined reagent signal:
Enhancing is from least one frequency of the frequency of the modification of reagent; Or
Combination from by two or more reagent samples in step (a) at least, (b) and the frequency of selecting in the signal that (d) produces down, wherein the frequency of Xuan Zeing is represented the selected chemical or biological aspect of two or more reagent samples.
15. a method that is used to generate electromagnetic signal, described electromagnetic signal produce selected chemistry or the biological effect that the many aspects because of chemistry that adopts or biological reagent cause, this method comprises:
Sample is inserted in the checkout equipment of magnetic shielding, so that molecular signal to be provided;
Noise is injected in the checkout equipment of described magnetic shielding;
The noise that detect to inject and by the combination of the signal of described sample emission;
Reagent specific signal and noise are separated;
Calculate the frequency content of described reagent specific signal;
Strengthen the frequency content of described reagent specific signal by convergent-divergent or elimination frequency component;
The frequency content of the reagent attribute of identification representative expectation; And
Use produces signal from the detected selected enhancing frequency synthesis galvanomagnetic effect of different reagent, and it is part or all of that wherein Xuan Ding frequency is represented the expectation of the chemistry of described reagent or biological effect.
16. method according to claim 15 wherein, utilizes user interface to strengthen the frequency content of described reagent specific signal at least by the user.
17. the equipment of the signal of at least one subclass that is used to produce the effect with one or more chemistry or biological chemical reagent, this equipment comprises:
(i) carriage is applicable to the sample of admitting reagent;
(ii) adjustable noise source is used for applying the sample of noise to described carriage;
(iii) detecting device is used to write down the time-domain signal of being made up of sample radiation and described noise;
(iv) storage arrangement is used to store the signal of detection;
(v) computing machine is applicable to:
(a) take out the signal of storing from described storage arrangement;
(b) frequency spectrum designation of the described signal of generation allows the specific time-domain signal of identification agent; And
(c) revise a plurality of parts of the signal of described taking-up via user interface or software program, with the part of at least one expectation of the signal that strengthens or weaken described taking-up; And
(vi) compositor, its utilize at least one reagent signal selected modification part combination and produce signal.
18. equipment according to claim 17, wherein element (v), (vi) or they the two remotely place with respect to other element of described equipment, and with other element radio communication.
19. generation signal that is used to influence the biological or chemical system, wherein, the Fourier transform of described signal comprises a plurality of peak values, each peak value is corresponding to the frequency of the compound particular random incident that is produced by the known compound that causes detectable response in biological targets, and it is observed by the time-domain signal that writes down described sample in the sample that noise is injected into described compound with selected noise amplitude, described selected noise amplitude allows to discern described crest frequency when described time-domain signal is transformed frequency domain, wherein:
Described signal frequency peak value is the crest frequency that identifies of one or more compounds, and represents the chemistry or the biological effect of described compound; Or
Described signal frequency peak value is the frequency of selecting from the crest frequency that identifies of one or more compounds of controlling, and represents the enhancement effect of some aspect of described chemistry or biologic artifact.
20. generation signal according to claim 19, wherein, described signal generates by following steps:
(i) discern the crest frequency of two or more compounds, each compound can produce given detectable response in given biological targets;
(ii) discern those total crest frequencies of described compound; And
The total crest frequency that identifies in (iii) being superimposed upon (ii) is to generate electromagnetic waves.
21. generation signal according to claim 19, wherein, described signal generates by following steps:
(i) identification can produce the crest frequency in first group of compound of given or the detected response expected in given biological targets, and is identified in the crest frequency in second group of compound that can't produce such Expected Response in the described target;
It is total (ii) to discern all compounds in first group, but is not those total crest frequencies of all compounds of second group; And
Some the total crest frequency at least that identifies in (iii) being combined in (ii) is to generate electromagnetic waves.
22. generation signal according to claim 19, wherein, described signal generates by following steps:
(i) identification can produce the crest frequency in first group of compound of given or the detected response expected in given biological targets;
(ii) identification can produce the crest frequency in second group of compound of detected response of another expectation in identical biological targets;
(iii) discern total crest frequency of all compounds in first group and second group the total crest frequency of all compounds; And
Some frequency at least in two groups of total crest frequencies that identify in (iv) being superimposed upon (iii) is to generate electromagnetic waves.
23. generation signal according to claim 19 wherein, generates signal and may further comprise the steps:
(i) crest frequency of the given compound of identification, and
(ii) being that the selected amplitude of the 2x on the baseline noise frequency is come combination frequency at least.
24. generation signal according to claim 23, wherein, the step that generates signal also comprises:
Step (i) comprises the crest frequency of discerning two or more compounds, and each compound can produce given detected response in given biological targets, and discerns those total crest frequencies of these compounds; And
Step (ii) comprises the total crest frequency that stack identifies like this, to generate electromagnetic waves.
25. generation signal according to claim 23, wherein, the step that generates signal also comprises:
Step (i) comprises that identification can produce the crest frequency in first group of compound of detected response of given or expectation and can produce crest frequency in second group of compound of such Expected Response in described target in given biological targets, and discerns that all compounds in first group have but be not those crest frequencies that have for all compounds of second group; And
Step (ii) comprises some total crest frequency at least that combination identifies like this, to generate electromagnetic waves.
26. generation signal according to claim 23, wherein, the step that generates signal also comprises:
Step (i) comprises that identification can produce the crest frequency in first group of compound of detected response of given or expectation in given biological targets, identification can produce the crest frequency in second group of compound of detected response of another expectation in identical biological targets, and discerns those total crest frequencies of all compounds in first group and those total crest frequencies of all compounds of second group; And
Stack identifies like this, some frequency at least in two groups of total crest frequencies that step (ii) comprises is to generate electromagnetic waves.
27. generation signal according to claim 19, wherein, described signal is sent to remote transducer, and is applied in chemistry or biosystem causing response, and wherein said transducer is implanted to described system in, is placed near or the handheld mobile device of described system.
28. a method that produces electromagnetic signal signature, described electromagnetic signal signature are that described method comprises from the material radiation that is encouraged:
Controlled electromagnetic noise is injected in the container that does not have material;
Calculate first frequency spectrum of the electromagnetic radiation in the described container;
Interested material is placed in the described container;
Controlled electromagnetic noise is injected in the container that comprises described material;
Calculate second frequency spectrum of the electromagnetic radiation in the described container;
By comparing the frequency spectrum that first frequency spectrum that calculates and second frequency spectrum that calculates obtain described material; And
Strengthen the content of the frequency spectrum of described material.
29. method according to claim 28, wherein, the information of the enhancing frequency content of relevant signal is sent to remote transducer, and wherein said transducer is implanted in the biosome, is placed near the biosome or handheld mobile device.
30. an equipment that is used to generate the signal of representing chemistry or biological specimen, this equipment comprises:
(i) carriage is applicable to the admittance sample, container have magnetic shielding cover, electro-magnetic shielding cover or they the two;
(ii) adjustable noise source is used for the sample that is applied to respect to the noise of sample on the carriage, so that cause with respect to the resonance at random from the electromagnetic radiation of sample;
(iii) detecting device is used to write down the time-domain signal of being made up of sample electromagnetic radiation and noise;
(iv) storage arrangement is used to store time-domain signal;
(v) robot calculator is applicable to:
(a) take out the time-domain signal that is stored in the storage arrangement;
(b) spectrogram of generation time-domain signal allows the specific time-domain signal of reagent according to the information Recognition the best on spectrogram; And
(c) handle a plurality of parts of the time-domain signal of described taking-up via user interface, so that strengthen or weaken at least one expectation part of the time-domain signal of described taking-up.
31. equipment according to claim 30, wherein the information of the frequency content of the manipulation of relevant signal is sent to remote transducer, and wherein transducer is implanted in the biosome, is placed near the biosome or handheld mobile device.
32. one kind is used for producing the equipment of the aspect of at least one chemistry or biological reagent to the influence of system according at least one reagent, this equipment comprises:
Receiver is used to receive the signal of processing, and wherein the signal of Chu Liing is generated by following steps:
Noise is injected in the sample of reagent, so that generate resonance at random;
The signal that record is made up of the sample source radiation on the noise that is superimposed on injection with different injection noise levels;
Represent the frequency of optimum reagent specific signal by the time-domain signal identification of analyzing preferred record; And
Produce signal by the synthetic response of following project:
At least one frequency of from the frequency of the identification of reagent sample, selecting; Or
The combination frequency of from the frequency of the identification of two or more reagent samples, selecting, the aspect of the chemistry of the reagent sample that the frequency of wherein selecting representative is adopted or the selection of biological effect.
33. one kind be used to send signal or information so that again radiation represent the transmitter of the electromagnetic signal of the part of at least one chemistry or bioactive agents or all effects, transmitter comprises:
Be used to store the device of the specific electromagnetic signal characteristic of reagent original or that strengthen;
Be used for the specific electromagnetic signal characteristic of reagent is transformed into the device in other territory that is used for signal Processing, information retrieval, manipulation, storage or their any combination;
Be used to write down the specific electromagnetic signal characteristic of reagent original or conversion, so that send later on the device that is used for regenerating with the specific electromagnetic signal of radiation reagent in the position of expectation;
Be used to select, strengthen and make up some of the specific electromagnetic signal of one or more reagent or the device of all characteristic; And
Wherein the specific electromagnetic signal characteristic of reagent obtains by following steps:
The sample that comprises reagent is placed in the container;
Noise is projected sample;
The electromagnetic signal that record is made up of sample source radiation and noise;
Analyze described signal and identification agent specific signal; And
Revise the reagent specific signal so that generate the best specific time-domain signal of reagent.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59154904P | 2004-07-27 | 2004-07-27 | |
| US60/591,549 | 2004-07-27 | ||
| US60/593,006 | 2004-07-30 | ||
| US60/602,962 | 2004-08-19 | ||
| US60/674,083 | 2005-04-21 |
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| Publication Number | Publication Date |
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| CN101473210A true CN101473210A (en) | 2009-07-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2005800254280A Pending CN101473210A (en) | 2004-07-27 | 2005-07-27 | System and method for collecting, storing, processing, transmitting and presenting very low amplitude signals |
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Cited By (5)
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| CN108310655A (en) * | 2013-03-15 | 2018-07-24 | 纳特维斯公司 | For implementing to treat, such as the controller and flexible coil for the treatment of of cancer |
| CN111073948A (en) * | 2019-07-04 | 2020-04-28 | 山东百多安医疗器械有限公司 | Non-contact cell weak magnetic determination method |
| CN113311366A (en) * | 2020-02-27 | 2021-08-27 | Aptiv技术有限公司 | Harness testing device and method for verifying connection during assembly of harness |
| CN114884857A (en) * | 2022-07-13 | 2022-08-09 | 中车工业研究院(青岛)有限公司 | Signal quality detection method and device and computer readable storage medium |
| CN117420527A (en) * | 2023-12-19 | 2024-01-19 | 南京航天工业科技有限公司 | Radar monitoring method based on broadband real-time spectrum analysis |
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2005
- 2005-07-27 CN CNA2005800254280A patent/CN101473210A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310655A (en) * | 2013-03-15 | 2018-07-24 | 纳特维斯公司 | For implementing to treat, such as the controller and flexible coil for the treatment of of cancer |
| CN108310655B (en) * | 2013-03-15 | 2021-11-26 | 纳特维斯公司 | Controller and flexible coil for performing therapy, such as cancer therapy |
| CN111073948A (en) * | 2019-07-04 | 2020-04-28 | 山东百多安医疗器械有限公司 | Non-contact cell weak magnetic determination method |
| WO2021000714A1 (en) * | 2019-07-04 | 2021-01-07 | 山东百多安医疗器械股份有限公司 | Non-contact cell flux-weakening determination method |
| CN113311366A (en) * | 2020-02-27 | 2021-08-27 | Aptiv技术有限公司 | Harness testing device and method for verifying connection during assembly of harness |
| CN114884857A (en) * | 2022-07-13 | 2022-08-09 | 中车工业研究院(青岛)有限公司 | Signal quality detection method and device and computer readable storage medium |
| CN114884857B (en) * | 2022-07-13 | 2022-10-25 | 中车工业研究院(青岛)有限公司 | Signal quality detection method and device and computer readable storage medium |
| CN117420527A (en) * | 2023-12-19 | 2024-01-19 | 南京航天工业科技有限公司 | Radar monitoring method based on broadband real-time spectrum analysis |
| CN117420527B (en) * | 2023-12-19 | 2024-03-12 | 南京航天工业科技有限公司 | Radar monitoring method based on broadband real-time spectrum analysis |
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