CN101385702A - Lidocaine hydrochloride mucilage preparation method - Google Patents
Lidocaine hydrochloride mucilage preparation method Download PDFInfo
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- CN101385702A CN101385702A CNA2008101213372A CN200810121337A CN101385702A CN 101385702 A CN101385702 A CN 101385702A CN A2008101213372 A CNA2008101213372 A CN A2008101213372A CN 200810121337 A CN200810121337 A CN 200810121337A CN 101385702 A CN101385702 A CN 101385702A
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- lidocaine hydrochloride
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Abstract
A method for preparing a lidocaine hydrochloride mucilage comprises the following steps: a formula amount of ethyl p-hydroxybenzoate is put into purified water which accounts for 25% of the total volume of the ethyl p-hydroxybenzoate, heated and stirred until complete dissolution, added with a formula amount of lidocaine hydrochloride and stirred for dissolution, added with a formula amount of glycerol and stirred evenly; additionally, a formula amount of sodium carboxymethyl cellulose is added to purified water which accounts for 50% of the total volume of the sodium carboxymethyl cellulose, and stirred for complete swelling; the two solutions obtained are mixed evenly, and added with 0.1N sodium hydroxide to adjust the pH value to 6.0-7.0; the monarch drug content of the obtained mucilage is determined; the mucilage is added with water to sufficient amount, mixed evenly and filled, and sterilized by 110 DEG C saturated vapor for 30 minutes; inspected under a lamp and packaged to obtain the finished product. Compared with the prior art, the lidocaine hydrochloride mucilage has the advantages of matching anaesthesia and inspection time, good lubricating property and sterility assurance level.
Description
[technical field]
The invention belongs to a kind of preparation method of the lidocaine hydrochloride mucilage that before gastroscopy, uses.
[background technology]
Gastroscopy is one of the most frequently used means of diagnosis and treatment upper digestive disease, and it has the irreplaceable effect directly perceived of other clinical means.Yet because when doing gastroscopy, patient easily causes nausea, vomits, chokes and symptom such as cough because of the bottleneck throat irriate, and bears bigger misery, causes a lot of patients because of fearing, frightenedly refusing inspection.Eliminate the ill symptoms that gastroscopy produced, method commonly used at present is oral local anaesthetics.The lidocaine hydrochloride oral formulations is one of oral local anaesthetics, and it has, and absorption is fast, local anaesthesia is effective, strong to the mucosa penetration power, and does not have advantages such as local excitation and blood vessel dilating effect, is present most widely used local anaesthetics.But there are the following problems in actual applications for existing lidocaine hydrochloride oral formulations: 1, medicinal liquid is shorter in the time of contact of bottleneck throat and mucosa, and drug effect is influenced to some extent.2, greasy property is not good enough, stimulates the bottleneck throat mucosa easily when inserting mirror yet, cause patient choke cough, feel sick, untoward reaction such as vomiting, be difficult to eliminate fully patient's misery.3, the asepticize degree is low, has the courses of infection phenomenon.
[summary of the invention]
For overcoming the problems referred to above that prior art exists, the present invention aims to provide a kind of lidocaine hydrochloride mucilage preparation method, with the lidocaine hydrochloride mucilage that this method is prepared from, have that anesthesia was complementary with the review time, greasy property is good and product reaches the advantage of aseptic level.
For achieving the above object, the present invention has adopted following technical scheme: the ethylparaben of recipe quantity is put in 25% the purified water of cumulative volume, heating, stirred and make dissolving fully, the lidocaine hydrochloride that adds recipe quantity, stirring and dissolving, the glycerol of adding recipe quantity stirs; The carmethose that other gets recipe quantity is put in 50% the purified water of cumulative volume, stirring makes complete swelling, above-mentioned two kinds of liquid mixing are even, regulate pH value to 6.0-7.0 with the 0.1N sodium hydroxide, measure the drug content of rubber cement, add water to capacity, mix homogeneously, fill, under 110 ℃ of saturated vapor conditions the sterilization 30 minutes, lamp inspection, the packing product.
Beneficial effect: compared with prior art, because the present invention has added glycerol and carmethose in preparation process, 30 minutes technical scheme of 110 ℃ of saturated vapor condition sterilizations is adopted in sterilization, and carmethose is as thickening agent, and glycerol is as lubricant, thereby make this product possess greasy property, delay drug absorption simultaneously, make and anaesthetize the advantage that is complementary with the review time, help reducing stimulating, alleviate patient choke cough, feel sick, untoward reaction such as vomiting, product has reached aseptic level.
This lidocaine hydrochloride mucilage is a kind of gastroscopy premedicant of succeeding in developing on the lot of experiments basis, and thickening agent, lubricant formulation form in right amount by lidocaine hydrochloride for it in addition.This product has the following advantages:
1, have stickiness and lubricity preferably, medicinal liquid inflow bottleneck throat is moments later slowly swallowed when taking, and medicinal liquid can evenly be coated bottleneck throat, medicinal liquid fully contacts with the bottleneck throat mucosa, play good anesthesia and lubrication, rapid-action to the anesthetic action of bottleneck throat, anaesthetic effect is good; The good lubrication effect of this product simultaneously is convenient to insert mirror, improves and inserts the mirror success rate, can reduce stimulation, reduces patient's misery and untoward reaction.Clinical trial shows, before the art oral lidocaine hydrochloride mucilage choke in the reduction of patient gastroscopy process effectively cough, feel sick, vomiting, uncooperative, difficult intubation, the gastrointestinal tract inner foam reduces, pylorus alternately open with close well.
2, this product contains adhesion agent, can slow drug absorption and retarding action, and make the action time of medicine controlled, prevent that drug absorption is too fast, the too short and medication repeatedly of effective drug duration.Adopt this product, only need single administration before the art, can obtain effect preferably, compare (the each inspection needs spraying 2～3 times) with the spraying that 2% dicaine solution and 2% lignocaine aqueous solution are pharyngeal, simplified working procedure, alleviated the nurse job amount, not only made things convenient for administration but also accepted by patient easily.
3, this product can reduce the surface tension of gastrointestinal tract inner foam, and lather collapse is disappeared, and eliminates the foam in the gastrointestinal tract effectively, make the mirror downward view clear, avoid omitting minute lesion, improve accurate rate of diagnosis, shorten the gastroscopy time simultaneously, increase work efficiency.
4, this product is oral formulations, and is easy to use, can avoid cross infection again.5, apparent side effect is not seen in clinical trial, and this product is safe in utilization.
Therefore, using lidocaine hydrochloride mucilage before the gastroscopy is a kind of safe, economical, method efficiently, has both alleviated the medical and nursing work amount, improves accurate rate of diagnosis, has alleviated patient's misery again, convenient drug administration, and the patient is easy to accept, and is suitable for hospitals at different levels use.Realize the industrialization of lidocaine hydrochloride mucilage, will provide brand-new selection scheme in the use of gastroscopy premedicant thing, greatly make things convenient for carrying out of gastroscopy for our province and even national hospital at different levels.Can predict, this product will obtain using more widely clinically, and the market space is wide, has good social benefit and economic benefit.
[specific embodiment]
Embodiment 1:
Get ethylparaben 6 grams and put in the 2500ml purified water, heating, stirring make dissolving fully, add lidocaine hydrochloride 200 grams, and stirring and dissolving adds glycerol 1200 and restrains, and stirs; Other gets carmethose 80 grams and puts in the purified water of 5000ml, stirring makes complete swelling, above-mentioned two kinds of liquid mixing are even, regulate pH value to 6.0 with the 0.1N sodium hydroxide, measure the drug content of rubber cement, add water to 10000 grams, mix homogeneously, fill, under 110 ℃ of saturated vapor conditions the sterilization 30 minutes, lamp inspection, the packing product.
Embodiment 2:
Get ethylparaben 6 grams and put in the 2500ml purified water, heating, stirring make dissolving fully, add lidocaine hydrochloride 200 grams, and stirring and dissolving adds glycerol 800 and restrains, and stirs; Other gets carmethose 90 grams and puts in the purified water of 5000ml, stirring makes complete swelling, above-mentioned two kinds of liquid mixing are even, regulate pH value to 7.0 with the 0.1N sodium hydroxide, measure the drug content of rubber cement, add water to 10000 grams, mix homogeneously, fill, under 110 ℃ of saturated vapor conditions the sterilization 30 minutes, lamp inspection, the packing product.
Claims (1)
1, a kind of lidocaine hydrochloride mucilage preparation method is characterized in that: the ethylparaben of recipe quantity is put in 25% the purified water of cumulative volume, heating, stirred and make dissolving fully, the lidocaine hydrochloride that adds recipe quantity, stirring and dissolving, the glycerol of adding recipe quantity stirs; The carmethose that other gets recipe quantity is put in 50% the purified water of cumulative volume, stirring makes complete swelling, above-mentioned two kinds of liquid mixing are even, regulate pH value to 6.0-7.0 with the 0.1N sodium hydroxide, measure the drug content of rubber cement, add water to capacity, mix homogeneously, fill, under 110 ℃ of saturated vapor conditions the sterilization 30 minutes, lamp inspection, the packing product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101213372A CN101385702A (en) | 2008-09-26 | 2008-09-26 | Lidocaine hydrochloride mucilage preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101213372A CN101385702A (en) | 2008-09-26 | 2008-09-26 | Lidocaine hydrochloride mucilage preparation method |
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| CN101385702A true CN101385702A (en) | 2009-03-18 |
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| CNA2008101213372A Pending CN101385702A (en) | 2008-09-26 | 2008-09-26 | Lidocaine hydrochloride mucilage preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007297A (en) * | 2012-12-25 | 2013-04-03 | 中国人民解放军兰州军区乌鲁木齐总医院 | Preparation method of lubricating agent for gastroscope |
| CN104888286A (en) * | 2015-05-26 | 2015-09-09 | 福州先亚生物科技有限公司 | Tetracaine hydrochloride endoscope lubricant and preparation method thereof |
| CN106492231A (en) * | 2016-11-03 | 2017-03-15 | 山东威高药业股份有限公司 | A kind of lidocaine hydrochloride tract lubricates infusion of dispelling |
| CN111388416A (en) * | 2020-02-26 | 2020-07-10 | 浙江康德药业集团股份有限公司 | Lidocaine hydrochloride mucilage |
| CN112587674A (en) * | 2020-12-28 | 2021-04-02 | 江苏瑞阳医疗科技有限公司 | Lubricating mucilage for gastroscope detection |
-
2008
- 2008-09-26 CN CNA2008101213372A patent/CN101385702A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007297A (en) * | 2012-12-25 | 2013-04-03 | 中国人民解放军兰州军区乌鲁木齐总医院 | Preparation method of lubricating agent for gastroscope |
| CN104888286A (en) * | 2015-05-26 | 2015-09-09 | 福州先亚生物科技有限公司 | Tetracaine hydrochloride endoscope lubricant and preparation method thereof |
| CN106492231A (en) * | 2016-11-03 | 2017-03-15 | 山东威高药业股份有限公司 | A kind of lidocaine hydrochloride tract lubricates infusion of dispelling |
| CN106492231B (en) * | 2016-11-03 | 2019-09-20 | 山东威高药业股份有限公司 | A kind of lidocaine hydrochloride cavity lubrication is dispelled infusion |
| CN111388416A (en) * | 2020-02-26 | 2020-07-10 | 浙江康德药业集团股份有限公司 | Lidocaine hydrochloride mucilage |
| CN111388416B (en) * | 2020-02-26 | 2022-03-08 | 浙江康德药业集团股份有限公司 | Lidocaine hydrochloride mucilage |
| CN112587674A (en) * | 2020-12-28 | 2021-04-02 | 江苏瑞阳医疗科技有限公司 | Lubricating mucilage for gastroscope detection |
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Open date: 20090318 |