CN101306404B - Blood composition preparation device and method - Google Patents
Blood composition preparation device and method Download PDFInfo
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- CN101306404B CN101306404B CN2008100121890A CN200810012189A CN101306404B CN 101306404 B CN101306404 B CN 101306404B CN 2008100121890 A CN2008100121890 A CN 2008100121890A CN 200810012189 A CN200810012189 A CN 200810012189A CN 101306404 B CN101306404 B CN 101306404B
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Abstract
The invention discloses a blood component preparation method and a preparation device thereof. A blood gathering bag tray with a pressing mechanism and a collecting bag tray are installed on a centrifuge shaft, and a blood collecting trigeminy bag is arranged on the tray. Blood centrifugation and separation and blood component collection are automatically and synchronistically accomplished, and the operation process of the centrifuge, the tray and a blood bag control clamp are manually controlled during the preparation process. The centrifuge is started to ensure the whole blood in the blood gathering bag to be centrifuged at high speed, after delamination appears, an air cell expands to press an elastic tray and the blood gathering bag, blood plasma and blood platelet in the upper layer are pressed into the collecting bag, then the pressing is stopped and the centrifuge is stopped when a set quantify is achieved; and red corpuscle preservative fluid is added into the blood gathering bag. The high purity separation of the blood component is realized, the system is completely closed and pollution free, and the quality of the blood component is high; the separation efficiency of the whole blood is high, and thereby the large scale multi-bag separation and the collecting operation are convenient; the key process is mechanized, the auxiliary process is artificial, and the working strength is small.
Description
Technical field
The invention belongs to blood component preparation device and preparation method field, be specifically related to a kind of blood component preparation device and preparation method.
Background technology
The utilization rate of valuable blood resource has greatly been improved being that preservation blood (preservation condition of each composition of blood is different) or patient blood transfusion all needs whole blood is prepared into blood constituent in the blood station.The whole blood that gather the blood station, main component is blood plasma, red blood cell, blood platelet and white blood cell.
At present, blood constituent in enormous quantities separates preparation, uses centrifuge and blood component separator more, and centrifuge and blood component separator are separate equipment separately, centrifugal blood and blood component collection can not be finished synchronously, and be earlier that whole blood is centrifugal usually, uses other device separates blood constituent again.Produce many problems thus: owing to need deceleration, stall after centrifugal the finishing, blood component collection is by manual operations, and the time is long, process is loaded down with trivial details; Time delays centrifugal and between blood constituent separates composition can occur and merge, and the blood plasma of preparation is sneaked into a certain amount of red blood cell usually, needs secondary centrifuging, is easy to destroy red blood cell again, and influences the quality and the output of blood constituent.The rotary synchronous centrifugal blood component preparation device of a kind of many casees of published day the present invention for information about in the recent period, each vertical whole blood collection bag and collecting bag placed in each case, between two bags pressing plate is arranged, whole blood through centrifugal, separate after, enter collecting bag by pressing plate squeezes blood composition, but cannot separating whole blood.
Summary of the invention
The present invention discloses a kind of blood component preparation device and preparation method, adopts the pellet type pressing mechanism, solves the technical problem that centrifugal blood, separation and blood component collection can not be finished simultaneously automatically.
Blood collection bags pallet and the collecting bag pallet that has pressing mechanism is installed on centrifuge of the present invention, the centrifugal arbor, on pallet, placed blood sampling three linked blood bags.Preparation process is by the operating process of Artificial Control centrifuge, pallet and blood bag.
Described centrifugal arbor is cylindric, merogenesis, is screwed into bearing by joint mouthful lead screw with a joint mouthful screw hole.Each nodal axisn upper end has one section inscribed square axle, the square axial length of a bottom nodal axisn to equate with blood collection bags pallet center square hole depth, above the square axial length of each nodal axisn equate with collecting bag pallet center square hole depth; Except that going up most a nodal axisn, one section joint mouthful lead screw is arranged on the plane of the square axle of other each nodal axisn upper end, except that a bottom nodal axisn, the height of other each nodal axisn upper end joint mouthful lead screw should be greater than collecting bag pallet center square hole depth; Below the lower end of second nodal axisn and above each nodal axisn, respectively have one with below the joint mouth screw hole that the joint mouth lead screw of a nodal axisn is complementary that joins.
The square axle of a bottom nodal axisn has the individual mouth of pipe of giving vent to anger of N/4 (N is 4 integral multiple) along horizontal perimeter on each axial plane, from N the mouth of pipe of giving vent to anger converge to the axle center along the downward axle center gas pipeline of axis, axle center appendix terminal communicates with air pump.
From the bottom to top, a blood collection bags pallet is installed in the middle of a bottom nodal axisn and second nodal axisn, two or polylith collecting bag pallet more are installed between above each nodal axisn of second nodal axisn successively, two adjacent collecting bag pallets can overlay same joint mouth, the square nut but installation is in the above screwed on lead screw earlier before, nut size, profile are identical with square hole, collecting bag pallet center, by joint mouthful screw column between each joint and joint mouthful screw hole each pallet and axle are assembled into integral body.
N restitope by the even layout of circumference arranged at the bottom of the described blood collection bags pallet, the tray edge of restitope correspondence extends upward Pallet side frame for certain altitude, more obliquely upward, extend to the spill pallet cover to center of circle direction, the pallet cover leading edge is bent downwardly slightly, approximately is bags of blood length from leading edge to the length of Pallet side frame, and the end, frame, lid three parts are one.Middle part at Pallet side frame inner face height makes horizontal draw-in groove, but level is inserted spring bed, the pallet cover shape that spring bed is relative with top, measure-alike; Spring bed is advisable can place the blood separation bag of having filled whole blood apart from the tray bottom height, and spring bed, can be advisable spring bed extruding downwards behind the air bag sufficient gas to insert the pancake air bag apart from last spill pallet cover.
Square hole, blood collection bags tray bottom center, be inserted on the square axle of the bottom nodal axisn of centrifuge, the square hole wall is along horizontal perimeter, and each limit wall has N/4 the air inlet mouth of pipe, matches with N/4 on each axial plane on the centrifugal arbor of relative square the mouth of pipe of giving vent to anger.Tray bottom inside has N bar appendix radial to tray bottom edge, Pallet side frame extension, the mouth of pipe of giving vent to anger on the through Pallet side frame inwall between spring bed and the pallet cover from N the air inlet mouth of pipe respectively.The air inlet pipe of air bag is inserted in Pallet side frame and gives vent to anger on the mouth of pipe.
Described collecting bag pallet is installed in blood collection bags pallet top, can be provided with two-layerly or more multi-layered, and relative with the blood collection bags pallet should have N up concave type restitope, and two surveys are provided with two folding shaft that make progress only to pallet by axle, and the pallet outward flange is upturned.
Described special-purpose one bags of blood, the volume size and the connected mode of blood collection bags and collecting bag are identical with present general multi-joint blood taking bag, only difference to some extent on conduit length.
The preparation method: centrifugal blood, separation and blood component are collected and are finished synchronously automatically, by the operating process of Artificial Control centrifuge, pallet and blood bag control folder.
Manually open the collecting bag control folder of the second layer and start centrifuge, when blood under the high speed centrifugation state, after layering appears in blood plasma, blood platelet and white blood cell and red blood cell, the Artificial Control air pump is given air pressure, send into air bag through gas pipeline, air bag expands and pushes spring bed, the suitable squeezes blood collection bag of spring bed, upper plasma, blood platelet and white blood cell when flowing into the second layer, conduit are in the empty bag of collecting bag of apocarpy, until set amount, the Artificial Control air pump reduces air pressure, and the extruding of subduction air bag manually stops centrifuge; Close the collecting bag control folder of the second layer, open the 3rd layer of control folder that red blood cell additive collecting bag is housed, inject the red blood cell additive in the red blood cell that in the ground floor blood collection bags, is extruded.
The present invention has realized the high purity separation of blood constituent owing to adopt the pellet type pressing mechanism, and system is totally-enclosed, pollution-free, composition blood quality height; Centrifugal blood, separation and blood component collection are finished synchronously, and separation of whole blood efficient height is convenient to many bags of separation in enormous quantities and is collected operation; Critical process mechanization aided process is manually changed, and working strength is little.
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
Fig. 1 is the blood component preparation device schematic diagram;
Fig. 2 is a blood collection bags pallet pressing mechanism schematic diagram;
Fig. 3 is the blood component preparation device vertical view.
Figure labeling description: centrifugal arbor 1, joint mouthful lead screw 2, joint mouthful screw hole 2 ', control folder 3, collecting bag 4, collecting bag pallet 5, folding shaft 6, conduit 7, pallet cover 8, pallet cover axle 9, air bag 10, Pallet side frame 11, blood collection bags 12, spring bed 13, blood collection bags pallet 14, gas pipeline 15, centrifuge 16, air pump 17, horizontal draw-in groove 18.
The specific embodiment
As shown in Figure 1, the centrifugal arbor 1 of preparation facilities centrifuge 16 is cylindric, merogenesis, is screwed into bearing 1 by joint mouthful lead screw 2 with a joint mouthful screw hole 2 '; There is one section inscribed square axle the upper end of each nodal axisn 1, and a bottom nodal axisn 1 square axial length equates with blood collection bags pallet 14 center square hole depths; Other each nodal axisn 1 square axial length equates with collecting bag pallet 5 center square hole depths; Except that going up most a nodal axisn, one section joint mouthful lead screw 2 is arranged on the plane of square axle 1 upper end of other each nodal axisn 1; Except that a bottom nodal axisn 1, the height of other each nodal axisn 1 upper end joint mouthful lead screw 2 should be greater than collecting bag pallet center square hole depth, except that a bottom nodal axisn 1, there is the joint mouth screw hole 2 ' that is complementary with last nodal axisn 1 joint mouthful lead screw 2 other each nodal axisn 1 lower end.
The square axle of a bottom nodal axisn 1 has two mouths of pipe of giving vent to anger along horizontal perimeter on each axial plane, from 8 mouths of pipe of giving vent to anger converge to the axle center along the downward axle center gas pipeline 15 of axis, gas pipeline 15 terminals in axle center communicate with air pump 17.
All there is the square hole at blood collection bags pallet 14 and collecting bag pallet 5 centers, blood collection bags pallet 14 is inserted in the centrifugal arbor of a bottom joint 1 upper end, two collecting bag pallets 5 are inserted in second joint respectively, the centrifugal arbor of the 3rd joint 1 upper end, also two collecting bag pallets 5 can be overlayed second joint, the square joint mouthful nut but installation is in the above screwed on the joint mouth lead screw 2 of second joint earlier before, joint mouthful nut size, profile is identical with square hole, collecting bag pallet 5 center, twist each joint mouthful lead screw 2 of jail and joint mouthful screw hole 2 ' respectively, make blood collection bags pallet 14 and collecting bag pallet 5 be mounted to one with centrifugal arbor 1.
Eight or 12 restitopes (eight restitopes in the present embodiment) by the even layout of circumference are arranged at the bottom of blood collection bags pallet 14 round trays usually, need frame 11 or be designed to the up concave type restitope around the restitope, to prevent blood collection bags 12 displacements and damaged when centrifugal, the tray edge of restitope correspondence has 8 Pallet side frames 12 that extend upward to certain altitude, again obliquely upward, extend to spill pallet cover 8 to center of circle direction, pallet cover 8 leading edges are bent downwardly slightly, be equal to or greater than blood collection bags 12 length from leading edge to the length of Pallet side frame 11, power is inhomogeneous in order to avoid the blood bag is squeezed causes the breakage of blood bag, the end, frame, covering three parts is one, pallet cover 8 can outwards open, and is convenient to picking and placeing of blood collection bags 12 and air bag 10.
As shown in Figure 2, make into horizontal draw-in groove 18 at the middle part of the inner face height of Pallet side frame 12, insert spring beds 13 at horizontal draw-in groove 18, the corresponding pallet cover in spring bed 13 and top 8 is measure-alike; Place whole blood blood collection bags 12 between spring bed 13 and tray bottom restitope, sack is towards centrifugal arbor 1, and total places 8 bags; Place pancake air bag 10 between spring bed 13 and pallet cover 8, the reclinate slightly leading edge of pallet cover 8 can hinder grade air bag 10 and outwards squeeze.
As shown in Figure 1, the square hole at blood collection bags pallet 14 centers is inserted on the centrifugal arbor 1 upper end square axle of first segment, and two mouths of pipe of giving vent to anger of each axial plane match on two air inlet mouths of pipe of each limit wall of square hole wall and the centrifugal arbor 1 of relative square.
Inside, 14 end of blood collection bags pallet has eight appendixs radial to pallet 14 feather edges, Pallet side frame 11 extensions, the mouth of pipe of giving vent to anger on through Pallet side frame 11 inwalls between spring bed 13 and the pallet cover 8 from eight air inlet mouths of pipe respectively.The air inlet pipe of air bag 10 is inserted in Pallet side frame 11 and gives vent to anger on the mouth of pipe.
As shown in Figure 3, collecting bag pallet 5 is installed in blood collection bags pallet 13 tops, can be provided with two-layerly, and relative with blood collection bags pallet 13 should have 8 restitopes, 1 liang of survey is provided with two folding shaft that make progress only 6 to collecting bag pallet 5 by axle, conveniently picks and places blood collection bags 12 and collecting bag 4; Collecting bag pallet 5 edges are upturned, support collecting bag 4 bottoms.
Described special-purpose one bags of blood, the volume size and the connected mode of blood collection bags 12 and collecting bag 4 are identical with present general multi-joint blood taking bag, only difference to some extent on conduit length.Be connected into one by conduit 7, control folder 3 is housed on the conduit 7 that enters collecting bag 4, the bottom is towards collecting bag pallet 5 outer rims without exception for sack, and conduit 7 ends are towards axle 1.
The preparation method: centrifugal blood, separation and blood component are collected and are finished synchronously automatically, by the operating process of Artificial Control centrifuge, pallet and blood bag.
When whole blood carried out the blood constituent preparation and prepares in to blood collection bags 12, the collecting bag 4 of the second layer was used for plasma collection, opens control folder 3; The 3rd layer collecting bag 4 is equipped with the red blood cell additive, and control folder 3 cuts out.
Start centrifuge 16, centrifugal arbor 1 and blood collection bags pallet 14,5 rotations of collecting bag pallet, whole blood in the blood collection bags 12 is carried out centrifugal, separation, blood is under the high speed centrifugation state, after blood plasma, white blood cell and blood platelet and the red blood cell layering, reduce centrifugal force, control air pump 17 simultaneously and give air pressure, send into air bag 10 through gas pipeline 15, air bag 10 expands and pushes spring bed 13, spring bed 13 suitable squeezes blood collection bags 12 are in upper plasma, blood platelet etc. in the collecting bag 4 empty bags of apocarpy when conduit 7 flows into the second layer; Strengthen centrifugal force, continue squeezes blood collection bag 12,, finish separation of whole blood until set amount, continue centrifugal a few minutes after, stop centrifuge 16.Control air pump 17 subtracts air pressure, and air bag 11 shrinks, and spring bed 13 sets back and puts, and manually opens the 3rd layer collecting bag 4 control folders 3, injects the red blood cell additive in the red blood cell that is extruded in ground floor blood collection bags 12.Preparation finishes.
Claims (7)
1. a blood component preparation device is installed blood collection bags pallet and collecting bag pallet on the centrifugal arbor, and the blood collection bags pallet has pressing mechanism; Adopt multi-joint blood taking bag and conduit, it is characterized in that: described centrifugal arbor is that cylindric, merogenesis is screwed into bearing by joint mouthful lead screw with a joint mouthful screw hole; Each nodal axisn upper end has one section inscribed square axle, the square axial length of a bottom nodal axisn to equate with blood collection bags pallet center square hole depth, above the square axial length of each nodal axisn equate with collecting bag pallet center square hole depth; Except that going up most a nodal axisn, one section joint mouthful lead screw is arranged on the plane of the square axle of other each nodal axisn upper end; Except that a bottom nodal axisn, the height of other each nodal axisn upper end joint mouthful lead screw should be greater than collecting bag pallet center square hole depth, below the lower end of second nodal axisn and above each nodal axisn, respectively have one with below the joint mouth screw hole that the joint mouth lead screw of a nodal axisn is complementary that joins; The square axle of a bottom nodal axisn has N/4 the mouth of pipe of giving vent to anger along horizontal perimeter on each axial plane, from N the mouth of pipe of giving vent to anger converge to the axle center along the downward axle center gas pipeline of axis, axle center gas pipeline terminal communicates with compression pump.
2. according to the described blood component preparation device of claim 1, it is characterized in that: described centrifugal arbor from the bottom to top, a blood collection bags pallet is installed in the middle of a bottom nodal axisn and second nodal axisn, two or polylith collecting bag pallet more are installed between above each nodal axisn of second nodal axisn successively, two adjacent collecting bag tray stack are placed on same joint mouth, a collecting bag pallet is installed the square nut of screwing on earlier before on lead screw in the above, the nut size, profile is identical with square hole, collecting bag pallet center, by joint mouthful lead screw between each joint and joint mouthful screw hole each pallet and axle is assembled into integral body.
3. according to the described blood component preparation device of claim 1, it is characterized in that: described blood collection bags pallet has pressing mechanism, N restitope by the even layout of circumference arranged at the bottom of the blood collection bags pallet round tray, the tray edge of restitope correspondence extends upward Pallet side frame for certain altitude, more obliquely upward, extend to the spill pallet cover to center of circle direction, the pallet cover leading edge is bent downwardly slightly, approximately is bags of blood length from leading edge to the length of Pallet side frame, tries to get to the heart of a matter, frame, disk cover three parts be one; Middle part at Pallet side frame inner face height makes horizontal draw-in groove, but level is inserted spring bed, the pallet cover shape that spring bed is relative with top, measure-alike; Spring bed can be placed the blood separation bag of having filled whole blood apart from the tray bottom height, and spring bed and last spill pallet cover distance can be inserted the pancake air bag.
4. according to the described blood component preparation device of claim 3, it is characterized in that: square hole, described blood collection bags tray bottom center, be inserted on the square axle of the bottom nodal axisn of centrifuge, the square hole wall is along horizontal perimeter, each limit wall has N/4 the air inlet mouth of pipe, matches with N/4 on each axial plane on the centrifugal arbor of relative square the mouth of pipe of giving vent to anger; Tray bottom inside has N bar appendix radial to tray bottom edge and the extension of each Pallet side frame from N the air inlet mouth of pipe respectively, the mouth of pipe of giving vent to anger on the Pallet side frame inwall in the middle of spring bed and the upper tray lid; The air inlet pipe of air bag is inserted in Pallet side frame and gives vent to anger on the mouth of pipe.
5. according to the described blood component preparation device of claim 1, it is characterized in that: described collecting bag pallet is installed in blood collection bags pallet top, can be provided with two-layer or more multi-layered, relative with the blood collection bags pallet should have N up concave type restitope, the collecting bag pallet is provided with two folding shaft that make progress only by the axle both sides, and the pallet outward flange is upturned.
6. according to claim 1 or 3 or 4 or 5 described blood component preparation devices, it is characterized in that: described digital N is 8 or 12.
7. according to the described blood component preparation device of claim 6, it is characterized in that: described digital N gets 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100121890A CN101306404B (en) | 2008-07-04 | 2008-07-04 | Blood composition preparation device and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100121890A CN101306404B (en) | 2008-07-04 | 2008-07-04 | Blood composition preparation device and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101306404A CN101306404A (en) | 2008-11-19 |
| CN101306404B true CN101306404B (en) | 2011-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2008100121890A Expired - Fee Related CN101306404B (en) | 2008-07-04 | 2008-07-04 | Blood composition preparation device and method |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444763B (en) * | 2008-11-25 | 2010-12-08 | 康炜 | Full automatic blood component preparation device and preparation method |
| US8870733B2 (en) * | 2010-11-19 | 2014-10-28 | Kensey Nash Corporation | Centrifuge |
| CN102489044B (en) * | 2011-12-01 | 2013-09-25 | 北京市红十字血液中心 | System and method for separating component blood based on vision images |
| CN114289194A (en) * | 2021-12-30 | 2022-04-08 | 昕慕(江苏)生物医药科技有限公司 | Blood component separator and use method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3679128A (en) * | 1969-08-11 | 1972-07-25 | Aga Ab | Centrifuge |
| CN1099652A (en) * | 1993-06-07 | 1995-03-08 | 泰尔茂股份有限公司 | Apparatus for and method of preparation of blood agent |
| DE4340678A1 (en) * | 1993-11-30 | 1995-06-01 | Hettich Andreas Fa | Blood product separation centrifuge with hydraulic drive |
| US6852074B1 (en) * | 1997-05-20 | 2005-02-08 | Zymequest, Inc. | Biological processing apparatus for expressing fluid material |
-
2008
- 2008-07-04 CN CN2008100121890A patent/CN101306404B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3679128A (en) * | 1969-08-11 | 1972-07-25 | Aga Ab | Centrifuge |
| CN1099652A (en) * | 1993-06-07 | 1995-03-08 | 泰尔茂股份有限公司 | Apparatus for and method of preparation of blood agent |
| DE4340678A1 (en) * | 1993-11-30 | 1995-06-01 | Hettich Andreas Fa | Blood product separation centrifuge with hydraulic drive |
| US6852074B1 (en) * | 1997-05-20 | 2005-02-08 | Zymequest, Inc. | Biological processing apparatus for expressing fluid material |
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| CN101306404A (en) | 2008-11-19 |
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