CN101191793A - Biosensing test sheet - Google Patents
Biosensing test sheet Download PDFInfo
- Publication number
- CN101191793A CN101191793A CNA2006101449865A CN200610144986A CN101191793A CN 101191793 A CN101191793 A CN 101191793A CN A2006101449865 A CNA2006101449865 A CN A2006101449865A CN 200610144986 A CN200610144986 A CN 200610144986A CN 101191793 A CN101191793 A CN 101191793A
- Authority
- CN
- China
- Prior art keywords
- corpse
- biological sensing
- test sheet
- laboratory examination
- chemical testing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a biosensing test piece which is applicable for distinguishing the biologic health condition or the disease infection of a test sample. The biosensing test piece at least comprises an insulating substrate and a capillary channel, wherein, the surface of the insulating substrate is provided with a print electrode; the capillary channel is arranged on the upper part of the insulating substrate and provided with two ends which are respectively provided with at least one fixed reaction area and at least one exhaust passage, herein, the exhaust passage is formed by the thickness of a gum and the shape of the gum. Therefore, the biosensing test piece of the invention can maintain the advantage of a siphoning type micro test sample, and can eliminate the complicated manufacturing procedure.
Description
Technical field:
The invention relates to a kind of biological sensing test sheet, particularly about the technical field of the mode of the loam cake gum that changes test pieces.
Background technology:
Along with the quick differentiation of science and technology, for disease or healthy diagnosis significant progress is also arranged, medical personnel's assistance and assistant are differentiated many labor intensive, time and cost with the interpretation of instrument yet above-mentioned diagnosis is rely more.Especially for the people that partly pay attention to privacy, its grasp for self health is considered as the some of the right of privacy mostly, before further seeking the medical treatment ﹠ health consultation and assisting, does not wish that other people know the health status of own body.Again or for busy modern, the complex steps of Gernral Check-up and wish to have a comparatively easy mode to check and know, wherein body fluid is comparatively universal in order to detect health status and medical diagnosis on disease, so various test pieces at the body fluid detection is arisen at the historic moment.
General comparatively common test pieces is many to see also Fig. 1 based on blood sugar test, is known blood sugar test sheet synoptic diagram.Test pieces has a corpse or other object for laboratory examination and chemical testing district 10 and puts position 11 in order to settle a test paper 110 in order to insert the blood and one that drips.Corpse or other object for laboratory examination and chemical testing district 10 and put 11 at position and still have a passage (figure does not show) to use the blood flow of making way in the corpse or other object for laboratory examination and chemical testing district 10 to arrive this test paper 110 through this passage, this moment, this test paper 110 produced change color, this tested test paper was inserted such as obtaining reading so that interpretation blood sugar or other diseases detected value in the blood sugar of hand-held or the other diseases detector together with test pieces again.
Yet at present many blood glucose test on the market, its mode that adds a corpse or other object for laboratory examination and chemical testing mainly is divided into drip-type and hydrocone type (capillary action mode).Wherein, the drip-type test piece is covered on the reaction zone with plastic net usually, that is the demand of a corpse or other object for laboratory examination and chemical testing is big and must be condensed into one and bleed, can be accurately and q.s drop to reaction zone.This measure is for quite inconvenience of operator, and easily causes operational error and then cause the regular waste of test piece.Review the hydrocone type test piece, adopting capillary action mode and a corpse or other object for laboratory examination and chemical testing because of it is to utilize the contact suction inlet to satisfy to be introduced reaction zone automatically, so the aequum of a corpse or other object for laboratory examination and chemical testing is less naturally.Only, end is seen the siphon function design of at present commercially available hydrocone type test piece, usually in the pairing other end punching of the suction inlet of a corpse or other object for laboratory examination and chemical testing, or keeps the exhaust hole between the base material of its hydrocone type test piece and dividing plate.To this, the required production and processing program of hydrocone type test piece is quite numerous and diverse naturally.
For the advantage of possessing hydrocone type simultaneously and exempt its shortcoming.The inventor is based on going in for the study for many years and many practical experience, inquires into special topic through research and design in many ways, satisfies in the present invention to propose a kind of biological sensing test sheet with as aforementioned expectation one implementation and foundation.
Summary of the invention:
Because above-mentioned problem, fundamental purpose of the present invention except that the advantage of the required more a spot of corpse or other object for laboratory examination and chemical testing of the above-mentioned known hydrocone type test piece of available reservation, more can be exempted numerous and diverse production and processing program in the above-mentioned known hydrocone type test piece for a kind of biological sensing test sheet is provided.
Edge is that for reaching above-mentioned purpose, biological sensing test sheet of the present invention includes an insulated substrate and a capillary channel at least.The insulated substrate here has and can be provided with one at least one surface and this surface and print electrode.And the capillary channel here is located at insulated substrate top place and have the exhaust passage that place, two ends at least can be respectively equipped with at least one fixation reaction district and at least one direction.Wherein, a contact corpse or other object for laboratory examination and chemical testing in the end place in mat fixation reaction district carries out exhaust by the exhaust passage of one or more directions, to spread and to adsorb a corpse or other object for laboratory examination and chemical testing in the fixation reaction district.Note that the exhaust passage here then can utilize the thickness of a gum and shape thereof to constitute.
From the above, biological sensing test sheet of the present invention more comprises a suction inlet, for introducing a corpse or other object for laboratory examination and chemical testing to the fixation reaction district.That is when a corpse or other object for laboratory examination and chemical testing when its suction inlet, a corpse or other object for laboratory examination and chemical testing then is introduced into the fixation reaction district rapidly, the air of being carried secretly when introducing simultaneously then can be discharged via its exhaust passage.In addition, when the fixation reaction district is typically provided with a material with oxidation or reducing power, to produce a narrow spectrum biochemical reaction with a corpse or other object for laboratory examination and chemical testing by this and then by the generation electron transfer that prints electrode.At last, the biological sensing test sheet of the present invention electrochemical biological sensing device of then can arranging in pairs or groups can measure the concentration content of some predetermined substance in the corpse or other object for laboratory examination and chemical testing then according to this electron transfer, and then as the reference frame of learning biological health status or disease infection.
The invention has the beneficial effects as follows: can exempt production and processing program numerous and diverse in the hydrocone type test piece, keep the advantage of the required more a spot of corpse or other object for laboratory examination and chemical testing of hydrocone type test piece.
Description of drawings:
Fig. 1 is known blood sugar test sheet synoptic diagram;
Fig. 2 is the synoptic diagram of capillary channel of the present invention;
Fig. 3 is the synoptic diagram of biological sensing test sheet interlayer of the present invention;
Fig. 4 is the synoptic diagram of insulated substrate of the present invention.
The figure number explanation:
10: corpse or other object for laboratory examination and chemical testing district; 11: put the position;
110: test paper; 20: capillary channel;
201: the fixation reaction district; 202: the direction of exhaust passage;
203: gum; 204: a corpse or other object for laboratory examination and chemical testing sucks direction;
30: interlayer; 301: breach;
40: look edge substrate; 401: the surface;
4011: print electrode.
Embodiment:
For above-mentioned purpose of the present invention, feature and advantage can be become apparent, hereinafter according to biological sensing test sheet of the present invention, and cooperate appended correlative type, be described in detail below.
See also the synoptic diagram of Fig. 2 for the capillary channel 20 that the present invention censured.This capillary channel 20 is to utilize the thickness of a gum 203 (oblique line) and the shape of gum 203 thereof to constitute place, two ends at least, it more is respectively equipped with the exhaust passage of at least one fixation reaction district 201 and at least one direction 202, fixation reaction district 201 can be provided with a material with oxidation or reducing power in advance, for producing a narrow spectrum biochemical reaction with a corpse or other object for laboratory examination and chemical testing; A corpse or other object for laboratory examination and chemical testing is contacted with fixation reaction district 201, carries out exhaust by the exhaust passage of aforementioned direction 202, sucks with direction 204, makes corpse or other object for laboratory examination and chemical testing diffusion and is adsorbed in fixation reaction district 201.
See also the synoptic diagram of Fig. 3 for biological sensing test sheet interlayer of the present invention.This interlayer 30 is provided with a breach 301 in the fixation reaction district 201 that corresponding diagram 2 censured, and increases the space in fixation reaction district 201 by the thickness of interlayer 30, carries out biochemical reaction with the corpse or other object for laboratory examination and chemical testing of absorption q.s.
See also the synoptic diagram of Fig. 4 for the insulated substrate 40 that the present invention censured.This insulated substrate 40 have at least one surperficial 401 and its surface 401 on can be provided with one and print electrode 4011.
Note that Fig. 2, Fig. 3 in this enforcement and the combination of Fig. 4, be synoptic diagram into biological sensing test sheet of the present invention.Fixation reaction district 201 correspondences that also are about to the capillary channel 20 among Fig. 2 are located at the breach 301 of interlayer 30 among Fig. 3.Continue, interlayer 30 is located at the place, top of the insulated substrate 40 among Fig. 3 then.
In addition, in the present embodiment, biological sensing test sheet should comprise a suction inlet (figure do not show), with provide a corpse or other object for laboratory examination and chemical testing near the time, a contact corpse or other object for laboratory examination and chemical testing is introduced into fixation reaction district 201 rapidly and the air carried secretly when introducing can be discharged by the exhaust passage of at least one direction 202.In this example, the preferable blood that can be of a corpse or other object for laboratory examination and chemical testing.Can be considered a main corpse or other object for laboratory examination and chemical testing of the present invention although please note blood, thought can further include biological serum, urine, saliva, tear etc. and not only exceed with blood.
Moreover, in this example, utilize blood of human body as whether detecting target with interpretation health status and infection risk.Also human finger finger tip, ear-lobe or venipuncture etc. are soon pierced through a blood corpse or other object for laboratory examination and chemical testing of gathering a microunit (μ L) in the back and are contacted above-mentioned suction inlet, or, after being mixed, the damping fluid of recycling dropper absorption a certain amount of (mL) contacts above-mentioned suction inlet more earlier with this blood corpse or other object for laboratory examination and chemical testing.The damping fluid here can be acid and adds the salt (KH2PO4) of acid or the alkali salt (NaHPO4) that adds alkali and for the hydrogen ion reaction that adds or remove, resist the change of pH value, and adds sodium hydroxid and distilled water constitutes.After treating that a blood corpse or other object for laboratory examination and chemical testing utilizes capillary channel 20 to introduce fixation reaction district 201, satisfy to produce produce a narrow spectrum biochemical reaction and the electron transfer of deriving and give electrochemical biological sensing device (figure does not look) and receive the concentration content that its electron transfer measures predetermined substance in the corpse or other object for laboratory examination and chemical testing, use and learn biological health status or caught (ANOMALOUS VARIATIONS appears in blood sugar) by this electrochemical biological sensing device.
The above only is an illustrative, but not is restricted person.Anyly do not break away from spirit of the present invention and category, and, all should be contained in the interest field of the present invention its equivalent modifications of carrying out or change.
Claims (7)
1. a biological sensing test sheet is applicable to biological health status or disease infection or the blood sugar concentration of differentiating a corpse or other object for laboratory examination and chemical testing, it is characterized in that this biological sensing test sheet comprises at least:
One insulated substrate has at least one surface and should the surface be provided with one and prints electrode;
One capillary channel is located at this place, insulated substrate top and is had place, two ends at least, and those places, two ends more are respectively equipped with the exhaust passage of at least one fixation reaction district and at least one direction;
Wherein, this end place in this fixation reaction district of mat contacts this corpse or other object for laboratory examination and chemical testing, carries out exhaust by the exhaust passage of those directions, to spread and to adsorb this corpse or other object for laboratory examination and chemical testing in this fixation reaction district.
2. biological sensing test sheet as claimed in claim 1 is characterized in that, those exhaust passages are to utilize the thickness of a gum and the shape of this gum to constitute.
3. biological sensing test sheet as claimed in claim 1 is characterized in that this biological sensing test sheet more comprises a suction inlet.
4. biological sensing test sheet as claimed in claim 3 is characterized in that, when this suction inlet provided this corpse or other object for laboratory examination and chemical testing close, the air of being carried secretly when making this corpse or other object for laboratory examination and chemical testing be introduced into this fixation reaction district and introducing was rapidly then satisfied by this exhaust passage discharge.
5. biological sensing test sheet as claimed in claim 1 is characterized in that, this fixation reaction district comprises and is provided with material and this corpse or other object for laboratory examination and chemical testing with oxidation or reducing power and produces a narrow spectrum biochemical reaction.
6. biological sensing test sheet as claimed in claim 5 is characterized in that, this narrow spectrum biochemical reaction is by this corresponding electron transfer that produces that prints electrode.
7. biological sensing test sheet as claimed in claim 6, it is characterized in that, the more alternative collocation one electrochemical biological sensing device of this biological sensing test sheet also receives the concentration content that this electron transfer measures predetermined substance in this corpse or other object for laboratory examination and chemical testing by this electrochemical biological sensing device, uses and learns this biology health status or disease infection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101449865A CN101191793A (en) | 2006-11-28 | 2006-11-28 | Biosensing test sheet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101449865A CN101191793A (en) | 2006-11-28 | 2006-11-28 | Biosensing test sheet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101191793A true CN101191793A (en) | 2008-06-04 |
Family
ID=39486922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101449865A Pending CN101191793A (en) | 2006-11-28 | 2006-11-28 | Biosensing test sheet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101191793A (en) |
-
2006
- 2006-11-28 CN CNA2006101449865A patent/CN101191793A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20240090804A1 (en) | Personal diagnostic device having a plurality of tubules | |
| Ates et al. | Integrated devices for non‐invasive diagnostics | |
| CN1320357C (en) | Test piece-bar container system | |
| AU2001249468B2 (en) | Method of preventing short sampling of a capillary or wicking fill device | |
| CN1273833C (en) | Device and method for sampling and testing components of biologic fluid via skin | |
| JP2007511770A (en) | Sample collection cup with integrated sample analysis system | |
| US20060094028A1 (en) | Rapid diagnostic assay | |
| CN101583393A (en) | Integrated sensor for analyzing biological samples | |
| JPH04223267A (en) | Nonreturnable reagent unit | |
| CN107121478A (en) | A kind of biology sensor that can detect that sample is not enough, method | |
| US20210132049A1 (en) | Simultaneous Parallel Signal Amplification and Analyte-Ligand Capture Functions | |
| CN101191793A (en) | Biosensing test sheet | |
| TWI329740B (en) | ||
| US11197658B2 (en) | Collection and treatment of a biofluid sample | |
| CN110346579B (en) | In-vitro HIV protease detection instrument and method based on nanopores | |
| CN105891281A (en) | Biosensing test piece | |
| AU2012200505A1 (en) | "Personal diagnostic devices and related methods" | |
| EP4374793A1 (en) | Device for testing analyte in liquid sample | |
| CN203535004U (en) | Electrochemical biosensor film layer of fiber derivative and interference layer compositing system thereof | |
| CN201222062Y (en) | Biology sensitive test slice | |
| Veronica et al. | Dermal-fluid-enabled detection platforms for non-invasive ambulatory monitoring | |
| CN116348764A (en) | Assay device and method for simultaneous separation of erythrocytes and proteins from a blood fluid sample | |
| TR2021017928A2 (en) | ELECTRODE SENSOR THAT CAN PERFORM MEDICAL TESTS | |
| Veronica et al. | Sensors & Diagnostics | |
| Yamanishi et al. | Biosensor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080604 |