CN101137895A - Sampling liquid container - Google Patents
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- CN101137895A CN101137895A CNA2006800079712A CN200680007971A CN101137895A CN 101137895 A CN101137895 A CN 101137895A CN A2006800079712 A CNA2006800079712 A CN A2006800079712A CN 200680007971 A CN200680007971 A CN 200680007971A CN 101137895 A CN101137895 A CN 101137895A
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Abstract
A sampling liquid container that overcomes the drawbacks of contamination and infection risk attributed to surveyor viruses and cumbersome handling. There is provided a sampling liquid container including a cylindrical vessel with open upper end and lower end; to install a liquid-tight dissolution liquid compartment in the cylindrical vessel, a stopper slidably inserted in the cylindrical vessel and a cap detachably fitted to the upper end of the cylindrical vessel; and an adaptor liquid-tightly fitted to the lower end of the cylindrical vessel, characterized in that the cylindrical vessel at the lower end has an inside diameter slightly larger than the outside diameter of the stopper, and that the adaptor accommodates the stopper pushed down when pressure is applied to the dissolution liquid compartment of the cylindrical vessel, and that a gap is created between the inside wall of lower end of the cylindrical vessel and the external surface of the stopper, and that the lower end of the cylindrical vessel is fitted with a dropping orifice.
Description
Technical field
The present invention relates to the sampling liquid container that the bacterioscopy of virus etc. is used.More particularly, the present invention relates to have the sampling liquid container of following structure, in this structure, at the following sampling liquid of modulation, promptly when sampling liquid that the reaction reagent container of the virus that is used for detecting influenza etc. drips, prevent that the examiner is subjected to the pollution of virus, the danger of infection.
Background technology
As the viral antigen of influenza etc. check a kind of, adopt in recent years and can check box (キ Star ト) by the influenza antigens that the bed side is checked.In addition, check box, can also detect the judgement of the A type Type B of influenza apace by this.Such inspection box generally adopts the immunochromatographiassay assay method, flows through (Off ロ-ス Le-) method, EIA method etc.In the where method in office, all be to drip the reaction reagent container, implement such as the mode of reaction kit by the sampling liquid that the sample that will take from the patient in advance is modulated into.Specifically, attract mucus from patient's nasal cavity, throat, or by after the cotton swab wiping by suction device, in lysate to its dissolving, be modulated into sampling liquid, it is dripped in the reaction reagent container.
As the container of the such sampling liquid of modulation, can enumerate the cap that to be pre-charged with the container that has cap of lysate and replace with mouthful cap that drips, the type of dripping (TOHKEMY 2004-109015 document).Such as, at first at extruded tube internal modulation sample treatment solution, then, the cotton swab of taking sample be impregnated in the sample treatment solution, sample is handled the modulation sampling liquid.In addition, in extruded tube, embed mouthful cap (pipe drips) that drips,, sample is dripped from the sample that mouthful cap that drips (pipe drips) drops onto the reaction reagent container the extruded tube counter-rotating.
Summary of the invention
In the container of the above-mentioned type, sampling liquid container can be same as before use container as dripping, can be since the 1st, make under each sample deviation fluid drips little, extraction uniformly in reaction reagent.In addition, if filtering bodies is installed on mouthful cap that drips (pipe drips),, still can not stop up even then under the situation that contains the high extract of toughness, solid.But in this occasion, when a mouthful cap (pipe drips) was dripped in installation, sampling liquid dispersed under the little situations such as occasion of the occasion, mouthful cap that drips that adhere to periphery etc., and the dangerous of examiner's infective virus taken place significantly to be increased.
In addition, in the occasion of the cap that is not installed on the special use on the mouth that drips, when the container of discarding after dripping, sampling liquid spreads in discarded container, and when offal treatment, the danger of infection has also increased.Even, also be attended by the operation that must prepare troubles such as mouthful cap that drips according to sample quantities separately in advance.So problem of the present invention provides the sampling liquid container of the shortcoming of the pollution, risk of infection of the virus of eliminating the examiner or complicated operation.
Another problem of the present invention is to provide the said sample sampling liquid container that easily container is taken out from stand.
Also have, another problem of the present invention is to provide the said sample sampling liquid container that can carry out the modulation of test liquid simply.
In addition, an also problem of the present invention is to provide the said sample sampling liquid container that disperses that can prevent sampling liquid.
That is, the present invention relates to a kind of sampling liquid container, this sampling liquid container comprises the cylindrical container of top and bottom end opening; Retainer and opening cap, so that the dissolving liquid chamber of fluid tightness is set in this cylindrical container inside, this retainer inserts the inside of cylindrical container slidably, this opening is installed on the top of this cylindrical container in mode removably with cap, and this sampling liquid container comprises the breakout box that is installed on the bottom of this cylindrical container with fluid-tight fashion, it is characterized in that the internal diameter of the bottom of cylindrical container is a bit larger tham the external diameter of retainer, breakout box holds retainer, this retainer is pressed when the dissolving liquid chamber of compressing cylindrical container, between the outside of the bottom of cylindrical container inwall and retainer, form the space, have the mouth of dripping in the bottom in addition.
In addition, in sampling liquid container of the present invention, be provided for catching the filtering bodies of high viscosity liquid up according to mode with mouthful adjacency of dripping.In addition, in sampling liquid container of the present invention, the mouth cap of installing in the mode of loading and unloading that drips is set at the above-mentioned mouth that drips.
In sampling liquid container of the present invention, by inserting retainer slidably, further have a mouth of dripping, drip to the dripping during liquid of reaction reagent container in modulation, can prevent the danger of pollution that the examiner is subjected to poison due to illness and produces, infection etc.In addition, the complexity that also can reduce to operate.
Usually, such sampling liquid container is listed in the such stand made of paper of developmental tube support at the state that erects, and it is contained in the outer container (packing case) of top opening.When the operator checks it, catch from the sidepiece of the top that the stand of this container is exposed it is taken out.
At this moment, has following problem, promptly, this container is being contained in the approaching substantially state of mode in the outer container according to a plurality of containers with good sealing property, upright regularly and arranged side by side, even catch the operator under the situation of upper portion, still be difficult to point the sidepiece that inserts container.This relatively situation, the physical dimension that each manufacturer is a bit larger tham the container cartridge body at the opening of stand is so that can have slightly more than needed at sidepiece when being contained in container in the stand; Sidepiece at container is provided with flange, according to the mode of come-up container is contained in the stand, the alignment of container have degree of freedom aspect spent time.
But, after taking sample, in order to improve the inspection precision, time is stood in the stand according to the rules with container once more, or, having bottom end vicinity at the exposed to contact cap of operator's finger in order to be undertaken by same containers that the occasion of same container is used in inspection more than 2 kinds or once more container to be stood in order to wait for inspection once more under the situation of occasion in the stand etc., sampling liquid, sample etc. disperses, the danger of the drop of residual dipping, infected dangerous the increasing of operator.
Also have, when importing the cap of sample specimens handling cask, catch the tube portion of container by a hand, a hand is caught the side of cap, and similarly, the operator has infected danger.
So, in order to solve above-mentioned problem, the inventor has carried out various in-depth analyses, consequently expects the mode of following danger of avoiding infection, in above-mentioned cylindrical container, take out container from stand easily, the border necessary grip part of (cap bottom) opening of the sidepiece when the installation of cap and container body is positioned at the position of separating, and cap can load and unload, in addition, be arranged on the sampling liquid container at the cap that has pinch hand on the end face, thus, realize the present invention.
That is, the present invention relates to a kind of sampling liquid container, this sampling liquid container is included in the top and has the cylindrical container that is used for sample specimens is imported the peristome of lysate; Be installed on the opening cap on the peristome of cylindrical container in mode removably; It is characterized in that being arranged on top and/or the bottom auxiliary body that stretch out, that take out this container of sampling liquid container.
In the present invention, by top and/or the bottom auxiliary body that stretch out, that take out container that is arranged on sampling liquid container, the examiner can easily take out sampling liquid container from storage case, and can prevent the pollution that virus causes, the danger of infection.
In such sampling liquid container,, will take the cotton swab of sample to impregnated in the sample treatment solution (lysate) by a hand in order to make test liquid, around cylindrical container, by the fingerhold cotton balls part of another hand, simultaneously, make cotton swab rotate a few, extract sample.Then, under the head of cylindrical container, the part on the liquid level is pushed the cotton balls part consumingly, extrudes liquid, takes out cotton swab simultaneously, forms test liquid.
But because of contain the mucus material in sample, they are pasted on the cotton swab, thus, the finger clamping on one side cotton balls part by the another hand around the cylindrical container only is Yi Bian the mode that makes cotton swab rotate a few is difficult to easily extract sample in sample treatment solution.
Another problem of the present invention is to provide a kind of sampling liquid container, and it can carry out the modulation of test liquid simply.
That is, the present invention relates to a kind of sampling liquid container, it comprises the cylindrical container of top and bottom end opening; Retainer and opening cap, so that the dissolving liquid chamber of fluid tightness is set in this cylindrical container inside, this retainer inserts the inside of this cylindrical container slidably, this opening is installed on the top of this cylindrical container in mode removably with cap, and this sampling liquid container comprises breakout box, this breakout box top is installed on the bottom of this cylindrical container with fluid-tight fashion, and has filtering bodies in the breakout box bottom and the mouth that drips, in addition, the internal diameter of the bottom of cylindrical container is a bit larger tham the external diameter of retainer, this breakout box holds retainer, this retainer is pressed when oppressing the dissolving liquid chamber of cylindrical container from the outside, and between the outside of the bottom of cylindrical container inwall and retainer, form the space, in the inside of above-mentioned cylindrical container, be provided for promoting in the dissolving of the inside of above-mentioned dissolving liquid chamber sample or the auxiliary body of extraction.
In the present invention, indoor at above-mentioned lysate by being provided for promotion, the dissolving of sample or the auxiliary body of extraction can carry out the modulation of test liquid simply.
In the said sample sampling liquid container, in the inner cylinder portion of above-mentioned breakout box, filtering bodies is set according to mode with mouthful adjacency of dripping, this filtering bodies is removed the impurity in the sampling liquid, and removes dope.But, has following problem, promptly, because above-mentioned retainer is formed by the material of rubber, high-elastic gonosome usually, block so in the keeping of sampling liquid container, produce, be bonding between the material, like this, in order to realize fluid connection, the sidepiece of extruding cylindrical container, the internal pressure of container is risen sharp, at this moment, unblocking hastily, by this impetus, retainer slides, and when being communicated with operation for sample being dripped in reaction reagent, sampling liquid resembles and disperses the water gun.
In order to prevent dispersing of sampling liquid, the inventor has carried out various in-depth analyses, consequently, suitably selects the aperture and the thickness of filtering bodies, and the aperture of the mouth that drips etc., can avoid such problem.
That is, the present invention relates to a kind of sampling liquid container, this sampling liquid container comprises the cylindrical container of top and bottom end opening; Retainer and opening cap, so that the dissolving liquid chamber of fluid tightness is set in this cylindrical container inside, this retainer inserts the inside of cylindrical container slidably, this opening is installed on the top of this cylindrical container in mode removably with cap, and this sampling liquid container comprises the breakout box that is installed on the bottom of this cylindrical container with fluid-tight fashion, and, the internal diameter of the bottom of this cylindrical container is a bit larger tham the external diameter of retainer, this breakout box holds retainer, this retainer is pressed when the dissolving liquid chamber of compressing cylindrical container, and between the outside of the bottom of cylindrical container inwall and retainer, form the space, in addition, have the mouth of dripping in its bottom, it is characterized in that in the inner cylinder portion of above-mentioned breakout box, filtering bodies is set according to mode with mouthful adjacency of dripping, this filtering bodies is continuous poriferous plastid, wherein, the aperture is in the scope of 0.1～20 μ m, and thickness is in the scope of 1.0～6.0mm.
In addition, best, the above-mentioned mouth that drips has its bore in the scope of 0.5～2mm, the hollow groove of its length in the scope of 6～15mm, and best in addition, the amount that is filled in the liquid in the above-mentioned dissolving liquid chamber is in the scope of 0.1～2.0mL.In addition, best, at the above-mentioned mouth that drips, with the mouth cap that drips of mode setting removably.
In the present invention, by aperture and the thickness of selecting above-mentioned filtering bodies, the bore and the length of dripping mouthful, and liquid filling amount when dripping sample in reaction reagent, can be eliminated sampling liquid and resemble the problem of dispersing the water gun etc.
Sampling liquid container of the present invention slidably inserts retainer, has the mouth of dripping in addition, thus, drips to the dripping during liquid of reaction reagent container in modulation, can prevent that the examiner is subjected to the danger of the pollution of virus, infection etc.In addition, the complexity that also can reduce to operate.In addition, top and/or the bottom auxiliary body that stretch out, that take out this container of sampling liquid container of the present invention by being arranged on sampling liquid container, take out container from stand easily, the border necessary grip part of (cap bottom) opening of the sidepiece when the installation of cap and container body is positioned at the position of leaving, load and unload this cap, thus, the danger that can avoid infection.In addition, in the present invention, can be by being provided for promoting that the dissolving of sample or the auxiliary body of extraction carry out the modulation of test liquid simply in above-mentioned lysate chamber interior.In addition, according to the present invention, by aperture and the thickness of selecting above-mentioned filtering bodies, the bore and the length of dripping mouthful, and liquid filling amount when dripping sample in reaction reagent, can be eliminated sampling liquid and resemble the problem of dispersing the water gun etc.
Description of drawings
Fig. 1 is the longitudinal sectional view of the preceding state of the use of an example of expression sampling liquid container of the present invention;
The longitudinal sectional view of the state when Fig. 2 adjusts for the dissolving of expression sampling liquid container shown in Figure 1;
The appearance assumption diagram of the state when Fig. 3 is dripping of expression sampling liquid container shown in Figure 1;
Fig. 4 is the longitudinal sectional view of an example of expression sampling liquid container of the present invention;
Fig. 5 is the front view of sampling liquid container shown in Figure 4;
Fig. 6 is the side view of sampling liquid container shown in Figure 4;
Fig. 7 is the vertical view of the pinch hand of sampling liquid container shown in Figure 4;
Fig. 8 is from storage case, takes out the appearance assumption diagram of sampling liquid container of the present invention by hand;
Fig. 9 is the longitudinal sectional view of the preceding state of the use of expression another sampling liquid container of the present invention;
Figure 10 is the cut-open view along the A-A line among Fig. 9;
The longitudinal sectional view of the state when Figure 11 modulates for the dissolving of expression sampling liquid container shown in Figure 9;
The appearance assumption diagram of the state when Figure 12 is dripping of expression sampling liquid container shown in Figure 9;
Figure 13 (a)～Figure 13 (c) is used to promote the longitudinal sectional view of another embodiment of the auxiliary body of the dissolving of sample specimens or extraction for expression is of the present invention;
The longitudinal sectional view of the state when Figure 14 is the lysate modulation of sampling liquid container shown in Figure 4;
The appearance assumption diagram of the state of Figure 15 during for the dripping of sampling liquid container shown in Figure 4.
Embodiment
Below by accompanying drawing, sampling liquid container of the present invention is specifically described.Fig. 1 is the longitudinal sectional view of expression sampling liquid container of the present invention, and Fig. 2 is illustrated in the longitudinal sectional view that inserts the state of the cotton swab of taking sample in the sampling liquid container of the present invention from peristome.Fig. 3 is the appearance assumption diagram of the following state of expression, at this state,, retainer is pressed from the dissolving liquid chamber of the cylindrical container of the sampling liquid container of outside compressing Fig. 1, the inner face of sampling liquid by cylindrical container and the space of the outside of retainer are from mouthful drippage that drips.
Sampling liquid container 1 of the present invention comprises the cylindrical container 2 of top and bottom end opening as shown in Figure 1; Retainer 3 and opening cap 4, so that the dissolving liquid chamber 7 of fluid tightness is set in this cylindrical container inside, this retainer 3 inserts the inside of cylindrical container 2 slidably, this opening is installed on the top of this cylindrical container 2 with cap 4 in mode removably, and this sampling liquid container 1 comprises the breakout box 5 that is installed on the bottom of this cylindrical container 2 with fluid-tight fashion.
Comprise having the part that its internal diameter is a bit larger tham the external diameter of retainer 3 in its bottom by the peristome that can screw togather opening usefulness cap 4 usually on the top of above-mentioned cylindrical container 2.In addition, can be at this bottom part interpolation breakout box 5.
At the bottom end vicinity of cylindrical container 2, insert slidably retainer 3, and on its top, with mode mounting cap 4 removably.By retainer 3 and cap 4 are installed, form dissolving liquid chamber 7 in the inside of cylindrical container 2.In this dissolving liquid chamber 7, be filled with the liquid of dissolved samples (nasal cavity wiping liquid, nasal cavity attracts liquid, throat wiping liquid etc.).Usually, this lysate is a water, and the reactivity of the sample when dropping onto in the reaction reagent in order to improve is added interfacial agent.In addition, add as antiseptic, sodium azide etc.
Sampling liquid for the inter-process that is squeezed in cylindrical container 2, be not limited to from outside compressing cylindrical container 2, make the tube portion distortion of cylindrical container 2, relatively the dissolving liquid measure relatively reduces to dissolve the occasion of the volume of liquid chamber, also can carry out physical mechanism extruding by other, or compression is positioned at the indoor gas of lysate, presses the operation that rises etc. in making.
So cylindrical container 2 preferably has the state that can confirm in the container, even and under the situation of compressing repeatedly, still not albefaction is transparent and flexible, and such material preferably adopts tygon, polypropylene, vestolit etc.
Because retainer 3 and cap 4 are assembled according to the mode of the fluid tightness of the dissolving liquid chamber that keeps cylindrical container 2, so there is not lysate to leak into outside danger from cylindrical container 2.
As the material of retainer 3, enumerate the resilient material of normal-butyl (ノ Le マ Le Block チ Le) rubber, halogenated butyl rubber, butadiene rubber, isoprene rubber, isobutene rubber, thermoplastic and high-elastic etc., usually, adopt thermoplastic and high-elastic.
In addition, slide smoothly, also can on retainer 3, cyclic rib be set in order to make.
Opening is installed on the cylindrical container 2 in mode removably with cap 4, usually, is screwed together on this cylindrical container 2.In addition, in order to keep fluid tightness, usually, the sleeve that engages with the openend inwall of cylindrical container is set.
If breakout box 5 is installed on the cylindrical container 2 according to the mode that keeps fluid tightness, then both can weld, also can be and bonding by solvent, in addition, also can engage at the state that be pressed into.Such material adopts tygon, polypropylene, ABS resin, polystyrene, BS resin, polycarbonate resin etc.
Above the inner chamber of breakout box 5, filtering bodies 6 is set according to mode with mouthful 8 adjacency of dripping.This filtering bodies 6 is the type with higher tack at the sample of taking from the patient, or comprises the occasion of solid, has the bore of catching the degree of said sample according to mouthful not obstruction mode of dripping.Filtering the big I of useful area and mesh freely selects.As such material, adopt tygon, polypropylene, fluorine resin, nylon resin etc., also adopt inorganic material etc., still, adopt the tygon sintered body usually.
When the modulation sampling liquid, as shown in Figure 2, at first, state is up opened the cap 4 of peristome, the bar of taking that is attached with the cotton swab etc. of the sample of taking from the patient is inserted the dissolving chamber of cylindrical container 2 from top end opening portion, extract sample by the lysate dissolving, the modulation sampling liquid.
Then, as shown in Figure 3, once more at the peristome mounting cap 4 of cylindrical container 2, to be positioned at mouthful 8 orientating reaction reagent containers that drip of the opposition side of container 2, thus, if the rising of the pressure inside that causes is then pushed by the tube portion with dissolving liquid chamber of compressing in the cylindrical container 2 by this, retainer 3 advances downwards, moves and is contained in the breakout box 5.Between the inwall of the outside of the retainer 3 that is received and breakout box 5, the space is set, this space can make the sampling liquids in the dissolving liquid chamber 7 can be by dripping therebetween.So sampling liquid can pass through this space,, drop onto in the reaction reagent container from mouthful 8 directed outwards of dripping.
By accompanying drawing, another sampling liquid container of the present invention is specifically described.
Fig. 4 is the longitudinal sectional view of the preceding state of the use of an example of expression sampling liquid container of the present invention, and Fig. 5 is the front view of the sampling liquid container of presentation graphs 4, and Fig. 6 is a side view.Fig. 7 is the top view of pinch hand.Fig. 8 for the operator with hand from accommodating the storage case of a plurality of sampling liquid containers, take out the appearance assumption diagram of this container.
Sampling liquid container 1 of the present invention comprises the cylindrical container 2 of top and bottom end opening as shown in Figure 4; Retainer (seal member) 3a and opening cap 4, so that inside at this cylindrical container, the dissolving liquid chamber 7 of fluid tightness is set, the inside that this retainer 3a inserts cylindrical container 2 slidably, this opening is installed on the top of this cylindrical container 2 with cap 4 in mode removably, and this sampling liquid container 1 comprises the breakout box 5a that is installed on the bottom of this cylindrical container 2 with fluid-tight fashion.
On the top of above-mentioned cylindrical container 2, comprise to screw togather the peristome of opening usually to have the part that its internal diameter is a bit larger tham the external diameter of retainer 3a in its bottom with cap 4.In addition, can be at this bottom part interpolation breakout box 5a.
At the bottom end vicinity of cylindrical container 2, insert slidably retainer 3a, and on its top, with mode construction opening removably with cap 4.By retainer 3a and opening being installed, form dissolving liquid chamber 7 in the inside of cylindrical container 2 with cap 4.In this dissolving liquid chamber 7, be filled with the liquid of dissolved samples (nasal cavity wiping liquid, nasal cavity attracts liquid, throat wiping liquid etc.).Usually, lysate is a water, and the reactivity of the sample when dropping onto in the reaction reagent in order to improve is added interfacial agent.In addition, add as the sodium azide of antiseptic etc.
Sampling liquid for the inter-process that is squeezed in cylindrical container 2, be not limited to from outside compressing cylindrical container 2, make the tube portion distortion of cylindrical container 2, relatively the dissolving liquid measure relatively reduces to dissolve the occasion of the volume of liquid chamber, also can carry out physical mechanism extruding by other, or compression is positioned at the indoor gas of lysate, presses the operation that rises etc. in making.
So cylindrical container 2 preferably has the state that can confirm in the container, even and under the situation of compressing repeatedly, still not albefaction is transparent and flexible, and such material preferably adopts tygon, polypropylene, vestolit etc.
Because retainer 3a and opening are assembled according to the mode of the fluid tightness of the dissolving liquid chamber that keeps cylindrical container 2 with cap 4, so there is not lysate to leak into outside danger from cylindrical container 2.
As the material of retainer 3a, enumerate the resilient material of normal-butyl (ノ Le マ Le Block チ Le) rubber, halogenated butyl rubber, butadiene rubber, isoprene rubber, isobutene rubber, thermoplastic and high-elastic etc., usually, adopt thermoplastic and high-elastic.
In addition, for smooth slip, also can on retainer 3, cyclic rib be set according to the mode that reduces with the contact area of inwall.
Opening is installed on the cylindrical container 2 in mode removably with cap 4, usually, is screwed together on this cylindrical container 2.In addition, in order to keep fluid tightness, usually, the sleeve that engages with the openend inwall of cylindrical container is set.
If breakout box 5a is installed on the cylindrical container 2 according to the mode that keeps fluid tightness, then both can weld, also can be and bonding by solvent, in addition, also can engage at the state that be pressed into.Such material adopts its hardness to be relatively higher than the cylindrical container polypropylene of (or its crooked elastic rate is higher than this container), ABS resin, polystyrene, BS resin, polycarbonate resin etc.
Above the inner chamber of breakout box 5a, filtering bodies 6a is set according to mode with mouthful 8 adjacency of dripping.This filtering bodies 6a is the type with higher tack at the sample of taking from the patient, or is comprising the occasion of solid, has the bore of catching the degree of this sample according to mouthful not obstruction mode of dripping.Filtering the size of useful area and mesh can freely select.As such material, adopt tygon, polypropylene, fluorine resin, nylon resin etc., also adopt inorganic material etc., still, adopt the tygon sintered body usually.
On mouthful 8a that drips, be provided with dripping mouthful that mode is removably installed with a cap 9.Drip mouthful with cap 9 with mode removably be installed on mouthful 8a that drips also can, its material selection adopts tygon usually than the material of the material softer that is used for breakout box, polypropylene, vestolit etc.In addition, also can form with breakout box 5a.In addition, also can stand on mode in the special-purpose container stand according to sampling liquid container, make special-purpose container stand diameter for the essentially identical size of tube portion diameter of cylindrical container 2.
Best, above-mentioned opening with cap 4 and/or drip mouthful with cap 9 end face have top board and with the continuous and vertically disposed perisporium of this top board, on the outer peripheral face of this perisporium, the jog of the anti-skidding usefulness when cap 4,9 is rotated is set auxiliaryly.
The invention is characterized in to have pinch hand 41, direction is not outstanding outward with the outer peripheral face on the end face of cap 4 from being arranged at above-mentioned opening for this pinch hand 41.In addition, in the present invention, have at above-mentioned mouthful the pinch hand 91 that drips with setting on the cap 9.In order successfully to load and unload cylindrical container 2 and breakout box 5, pinch hand 41 and 91 has particularly such length and the width of power that applies torque etc. along draw-off direction or sense of rotation easily.The size of pinch hand can be corresponding to the reagent container, the assembly of cotton swab of wrapping together, the size of storage case and freely setting.In addition, slide in order to prevent finger, and improve operability, in pinch hand 41 and 91, also can groove or fin be set along the direction perpendicular with loading and unloading direction.Perhaps, also can carry out the processing of pleat crape.Except carrying out these processing, also can be the processing that mode that crosswise intersects is stretched out etc., so that finger is fastened from any direction according to auxiliary body.Usually, best, adopt its hardness relatively to be higher than the cylindrical container polypropylene of (or its crooked elastic rate is higher than this container), ABS resin, polycarbonate resin, cyclic polyolefin, BS resin etc. as the opening that is provided with such pinch hand 41 with the material of cap 4.
In the present invention, by top and/or the bottom auxiliary body that stretch out, that take out container that is arranged on sampling liquid container, the examiner easily takes out sampling liquid container from storage case, and prevents the pollution of virus generation, the danger (with reference to Fig. 8) of infection.
When the modulation sampling liquid, at first, the state up makes the opening of peristome open with cap 4, and the bar of taking that is attached with the cotton swab etc. of the sample of taking from the patient is inserted the dissolving chamber of cylindrical container 2 from top end opening portion, extract sample by the lysate dissolving, the modulation sampling liquid.
Then, once more at the peristome of cylindrical container 2, construction opening cap 4, to be positioned at mouthful 8 orientating reaction reagent containers that drip of the opposition side of container 2, oppress the tube portion in the cylindrical container 2 then with dissolving liquid chamber, then push the rising of the pressure inside that causes by this, retainer 3a advances downwards, moves and is contained among the breakout box 5a.Between the inwall of the outside of the retainer 3a that has held and breakout box 5a, the sampling liquids that are provided with in the dissolving liquid chamber 7 can be by the space of dripping therebetween.So sampling liquid can pass through this space,, drop onto in the reaction reagent container from mouthful 8 directed outwards of dripping.
Adopt accompanying drawing, another sampling liquid container of the present invention is specifically described.Fig. 9 is the longitudinal sectional view of sampling liquid container of the present invention.Figure 10 is the cut-open view along the A-A line among Fig. 9.Figure 11 is illustrated in the sampling liquid container of Fig. 9, inserts the longitudinal sectional view of the state of the cotton swab of taking sample from peristome.Figure 12 presses retainer for the dissolving liquid chamber 7 of expression from the cylindrical container of the sampling liquid container of outside compressing Fig. 9, and the inner face of sampling liquid by cylindrical container and the space of the outside of retainer are from mouthful appearance assumption diagram of the state of drippage that drips.Figure 13 (a)～Figure 13 (c) is used to promote the longitudinal sectional view of another embodiment of the auxiliary body of the dissolving of sample of sampling liquid container of the present invention or extraction for expression.
Sampling liquid container 1 of the present invention comprises the cylindrical container 2 of top and bottom end opening as shown in Figure 11; Retainer 3a and cap 4, so that the dissolving liquid chamber 7 of fluid tightness is set in this cylindrical container inside, the inside that this retainer 3a inserts cylindrical container 2 slidably, this cap 4 is installed on the top of this cylindrical container 2 in mode removably, and this sampling liquid container 1 comprises the breakout box 5a that is installed on the bottom of this cylindrical container 2 with fluid-tight fashion.
On the top of above-mentioned cylindrical container 2, comprise the peristome that can screw togather cap 4 usually, in its bottom, have the part that its internal diameter is a bit larger tham the external diameter of retainer 3a.In addition, can be at this bottom part interpolation breakout box 5a.At the bottom end vicinity of cylindrical container 2, insert slidably retainer 3a, and on its top, with mode mounting cap 4 removably.By retainer 3a and cap 4 are installed, form dissolving liquid chamber 7 in the inside of cylindrical container 2.In this dissolving liquid chamber 7, be filled with the liquid of dissolved samples (nasal cavity wiping liquid, nasal cavity attracts liquid, throat wiping liquid etc.).Usually, lysate is a water, and the reactivity of the sample when dropping onto in the reaction reagent in order to improve is added interfacial agent.In addition, add as the sodium azide of antiseptic etc.
Sampling liquid for the inter-process that is squeezed in cylindrical container 2, be not limited to from outside compressing cylindrical container 2, make the tube portion distortion of cylindrical container 2, relatively the dissolving liquid measure relatively reduces to dissolve the occasion of the volume of liquid chamber 7, also can carry out physical mechanism extruding by other, or compression is positioned at the gas of lysate chamber 7, the operation that presses in making liter etc.So cylindrical container 2 preferably has the state that can confirm in the container, even and under the situation of compressing repeatedly the transparency of not albefaction and flexible still, such material preferably adopts tygon, polypropylene, vestolit etc.
The cotton swab here refers to medical sth. made by twisting cotton swab, specifically, refers to that the front end at plastics system or rod axis made of paper has the utensil of nonwoven fabrics etc., is used to take body fluid samples.The material of nonwoven fabrics adopts rayon, paper, PLA, cotton etc.
The invention is characterized in the inside that is provided for promoting at above-mentioned dissolving liquid chamber 7, the dissolving of sample or the auxiliary body of extraction 21.In this auxiliary body 21, have separates walls, it offers and makes cylindrical container 2 interior side-prominent, and cotton swab is inserted the through hole 24 of pars intermedia.As such separates walls, specifically, comprise circular protrusion 121 (Fig. 9, Figure 10) on the inwall that is arranged at above-mentioned cylindrical container 2, that be provided with continuously vertically, or be arranged on the inwall of above-mentioned cylindrical container 2, spiral helicine projection 221 (Figure 13 (a)), on the inwall of above-mentioned cylindrical container 2 with the isolated projection 321 of prescribed distance (Figure 13 (b)).
Best, in the circular protrusion 121 that is provided with continuously vertically, as shown in Figure 9, compare with the occasion on being arranged at whole of inwall, a plurality of circular protrusions are arranged on the internal face, between each projection, leave the part of the sense of hardening when slowing down the extruding cylindrical container.Circular protrusion shown in Figure 9 is formed by 4 projections, still, is not limited to this.Best, according to the mode that scrapes wiping liquid easily from cotton balls, the action that moves up and down corresponding to cotton balls strides across liquid level is arranged in the position that strides across liquid level up and down this circular protrusion usually.In addition, best, spaced apart following distance promptly can be because of not pushing the careless distance that is communicated with of retainer by the front end of cotton swab.The height of projection is preferably low as far as possible, so as when easily to obtain extruding in press liter.Specifically, usually should height in the scope of 0.1～0.3mm, as long as but can scrape and get wiping liquid, then can freely select corresponding to the size of cotton balls, shape.
In addition, best, in spiral helicine projection 221,, to compare with the occasion on being arranged at whole of inwall as shown in Figure 13 (a), 2～5 spiral helicine projection preferably is arranged on the internal face.Best, also usually according to the mode that scrapes wiping liquid easily from cotton balls, the action that moves up and down corresponding to cotton balls strides across liquid level is arranged in the position that strides across liquid level up and down this spiral helicine projection.In addition, best, spaced apart following distance promptly can be because of not pushing the careless distance that is communicated with of retainer by the front end of cotton swab.The height of the teeth of spiral is preferably low as far as possible, so as when easily to obtain extruding in press liter.Specifically, usually should height in the scope of 0.1～0.3mm, if but can scrape and get wiping liquid, then can freely select corresponding to the size of cotton balls, shape.
In addition, best, on inwall with the isolated projection 321 of prescribed distance as shown in 13 (b), be arranged on the internal face of the scope that when cylindrical container is erected, strides across liquid level, form each projection extruding the time do not harden sense, can pass through the height and the spacing of the degree of Visual Confirmation content from the outside.With the isolated projection of this prescribed distance, according to the mode that scrapes wiping liquid easily from cotton balls, the action that moves up and down corresponding to cotton balls strides across liquid level is arranged in the position that strides across liquid level up and down usually.In addition, best, spaced apart following distance promptly can be because of not pushing the careless distance that is communicated with of retainer by the front end of cotton swab.The height of projection is preferably low as far as possible, so as when easily to obtain extruding in press liter.Specifically, this highly is preferably in the scope of 0.1～0.3mm usually, if but can scrape and get wiping liquid, then can freely select corresponding to the size of cotton balls, shape.
In addition, above-mentioned auxiliary body 21 also can be as shown in Figure 13 (c), in the bottom of above-mentioned cylindrical container 2, and has from the bottom of above-mentioned cylindrical container 2 on the top of the part that keeps retainer 3, towards a plurality of post portion 22 that top orientation is stretched out.Top, top in this post portion 22 radially has the projection 421 of beam 23.By making cotton swab wipe the mode of rubbing beam 23, can scrape the mucus material that sticks on the cotton swab, after retainer 3 dropped, sampling liquid flowed in the gap of post portion 22 or beam 23, flows to filtering bodies 6.Usually according to the mode that scrapes wiping liquid easily from cotton balls, the action that moves up and down corresponding to cotton balls strides across liquid level roughly is arranged on the liquid level this beam.In addition, best, spaced apart following distance promptly can be because of not pushing the careless distance that is communicated with of retainer by the front end of cotton swab.In addition, according to the mode of the sidepiece of cotton balls contact, the sidepiece of beam has and equals cotton balls substantially, or is a bit larger tham its space.Get wiping liquid if can scrape, the quantity of beam, direction can freely be selected corresponding to the size of cotton balls, shape.
Above-mentioned auxiliary body 21 usually and cylindrical container form, still, also can be discrete item, assemble.Best, the material of the above-mentioned auxiliary body 21 of this occasion is formed such as elastomer by elastic body.The length of the degree that the length of the above-mentioned auxiliary body 21 of this moment also tilts not throw off during cylindrical container 2 for extruding if the situation by the Visual Confirmation content is not counteracted, then can freely be set.The projection of above-mentioned auxiliary body 21 must have and cotton swab can be inserted in the cylindrical container 2, and realizes the through hole 24 of motion freely.
When the modulation sampling liquid, as shown in Figure 11, at first, state is up opened the cap 4 of peristome, the bar of taking that is attached with the cotton swab etc. of the sample of taking from the patient is inserted the dissolving chamber of cylindrical container 2 from top end opening portion, it is moved up and down in auxiliary body 21, scrape sample, extract sample by the lysate dissolving, the modulation sampling liquid.
Then, as shown in Figure 12, once more at the peristome mounting cap 4 of cylindrical container 2, to be positioned at mouthful 8a orientating reaction reagent container that drips of the opposition side of cylindrical container 2, then, if the rising of the pressure inside that causes is then pushed by the tube portion with dissolving liquid chamber 7 of compressing in the cylindrical container 2 by this, retainer 3a advances downwards, moves and is contained among the breakout box 5a.Between the inwall of the outside of the retainer 3a that has held and breakout box 5a, the sampling liquids that are provided with in the dissolving liquid chamber 7 can be by the space of dripping therebetween.So sampling liquid can pass through this space, from mouthful 8a directed outwards of dripping, in the reaction reagent container that drips.
In the present invention, filtering bodies comprises sintered body, shaping foam element, nonwoven fabrics or superimposed fiber body etc.As such material, adopt tygon, polypropylene, fluorine resin, nylon resin etc., also adopt inorganic material etc., still, usually, adopt the tygon sintered body.
In the present invention, filtering bodies 6 is following continuous poriferous plastid, wherein, the aperture is in the scope of 0.1～20 μ m, best in the scope of 1.00～10 μ m, and its thickness is in the scope of 1.0～6.0mm, preferably in the scope of 1.5～4.5mm.Filtering bodies 6 both can be 1, also can be a plurality of.If the aperture of filtering bodies is less than about 0.1 μ m, then the viscosity of the sample of taking from the patient is high or comprise and the occasion of solid produce mouthful situation about stopping up of dripping.In addition, if surpass about 20 μ m, then sampling liquid is easily by filtering bodies, resembles easily to disperse the water gun.If the gas of inner chamber that thickness, then is positioned at the indoor sampling liquid of lysate less than about 1.0mm and is positioned at breakout box is at the state that mixes, easily by filtering bodies, sampling liquid resembles from the mouth that drips easily and disperses the water gun.If surpass about 7.5mm, then being used for path that filtering bodies passes through, too long the interfacial agent that comprises in the sampling liquid mixes with gas and complicated, easy foaming, and the situation that bubble is sneaked into from the front end of the mouth that drips is remarkable.
Best, above-mentioned dripping mouthfuls 8 has its bore in the scope of 0.5～3.5mm, preferably in the scope of 1.0～3.3mm, its length in the scope of 6～15mm, the best hollow groove in the scope of 6～12mm.In addition, the amount that is filled in the liquid in the breakout box 5 is usually with in the scope of 0.1～2.0mL, preferably in the scope of 0.4mL～1.5mL.
In Fig. 4, be provided with at mouthful 8a place of dripping with dripping mouthful that mode is removably installed with a cap 9.This drips mouthful and to be installed on mouthful 8a that drips its material employing tygon, polypropylene, vestolit etc. with cap 9 in mode removably.In addition, also can be integrally formed into breakout box 5a.In addition, also can found the mode of being located in the special-purpose container stand, make the barrel diameter of the diameter of special-purpose container stand and cylindrical container 2 roughly the same according to a plurality of sampling liquid containers 1.Also can on dripping mouthful with cap 9, pinch hand 91 be set.
When the modulation sampling liquid, as shown in Figure 14, at first, state is up opened the cap 4 of peristome, the bar of taking that is attached with the cotton swab etc. of the sample of taking from the patient is inserted the dissolving liquid chamber of cylindrical container 2 from top end opening portion, it is moved up and down on auxiliary body's 21 (not shown)s, scrape and smear sample, extract sample by the lysate dissolving, the modulation sampling liquid.
Then, as shown in Figure 15, once more at the peristome mounting cap 4 of cylindrical container 2, to be positioned at mouthful 8a orientating reaction reagent container that drips of the opposition side of cylindrical container 2, then, if the rising of the pressure inside that causes is then pushed by the tube portion with dissolving liquid chamber 7 of compressing in the cylindrical container 2 by this, retainer 3a advances downwards, moves and is contained among the breakout box 5a.Between the inwall of the outside of the retainer 3a that is received and breakout box 5a, the sampling liquids that are provided with in the dissolving liquid chamber 7 can be by the space of dripping therebetween.So sampling liquid can pass through this space,,, drop onto in the reaction reagent container from mouthful 8a directed outwards of dripping through filtering bodies 6.
Below by embodiment, the present invention is carried out more concrete description.
Embodiment 1
Preparation has the sampling liquid container (Fig. 1) of 3 kinds different sintering filtering bodies of the surface vacancies diameter shown in the table 1 (Off ィ Le sunset-レ Application is produced, high density polyethylene).The filling liquid measure that makes the dissolving liquid chamber (O.4～1.OmL) and the surface apertures (2.0～30 μ m) of filtering bodies, various variations (table 2～4) take place in thickness (1.5～6.0mm * 5), by the outside of hand extruding cylindrical container, the having or not of the water gun phenomenon when confirming fluid connection.
Table 1
The sintering filtering bodies
| Sample | The filtering bodies kind | Aperture (μ m) | Thickness (mm) | Number | Loading (mL) | The N | |
| A-1 | XHDPE | ||||||
| 2 | 1.5 | 1 | 1.0 | 5 | |||
| | XHDPE | 2 | 3.0 | 2 | 1.0 | 5 | |
| | XHDPE | 2 | 4.5 | 3 | 1.0 | 5 | |
| B-1 | UHDPE | 10 | 1.5 | 1 | 1.0 | 5 | |
| B-2 | UHDPE | 10 | 3.0 | 2 | 1.0 | 5 | |
| B-3 | UHDPE | 10 | 4.5 | 3 | 1.0 | 5 | |
| B-4 | UHDPE | 10 | 6.0 | 4 | 1.0 | 5 | |
| C-1 | XUHDPE | 30 | 1.5 | 1 | 1.0 | 5 | |
| C-2 | XUHDPE | 30 | 3.0 | 2 | 1.0 | 5 | |
| C-3 | XUHDPE | 30 | 4.5 | 3 | 1.0 | 5 |
Table 3
| Sample | The filtering bodies kind | Aperture (μ m) | Thickness (mm) | Number | Loading (mL) | The N | |
| A-11 | XHDPE | ||||||
| 2 | 1.5 | 1 | 0.7 | 5 | |||
| | XHDPE | 2 | 3.0 | 2 | 0.7 | 5 | |
| | XHDPE | 2 | 4.5 | 3 | 0.7 | 5 | |
| B-11 | UHDPE | 10 | 1.5 | 1 | 0.7 | 5 | |
| B-12 | UHDPE | 10 | 3.0 | 2 | 0.7 | 5 | |
| B-13 | UHDPE | 10 | 4.5 | 3 | 0.7 | 5 | |
| B-14 | UHDPE | 10 | 6.0 | 4 | 0.7 | 5 | |
| C-11 | XUHDPE | 30 | 1.5 | 1 | 0.7 | 5 | |
| C-12 | XUHDPE | 30 | 3.0 | 2 | 0.7 | 5 | |
| C-13 | XUHDPE | 30 | 4.5 | 3 | 0.7 | 5 |
Table 4
| Sample | The filtering bodies kind | Aperture (μ m) | Thickness (mm) | Number | Loading (mL) | The N | |
| A-21 | XHDPE | ||||||
| 2 | 1.5 | 1 | 0.4 | 5 | |||
| | XHDPE | 2 | 3.0 | 2 | 0.4 | 5 | |
| | XHDPE | 2 | 4.5 | 3 | 0.4 | 5 | |
| B-21 | UHDPE | 10 | 1.5 | 1 | 0.4 | 5 | |
| B-22 | UHDPE | 10 | 3.0 | 2 | 0.4 | 5 | |
| B-23 | UHDPE | 10 | 4.5 | 3 | 0.4 | 5 | |
| B-24 | UHDPE | 10 | 6.0 | 4 | 0.4 | 5 | |
| C-21 | XUHDPE | 30 | 1.5 | 1 | 0.4 | 5 | |
| C-22 | XUHDPE | 30 | 3.0 | 2 | 0.4 | 5 | |
| C-23 | XUHDPE | 30 | 4.5 | 3 | 0.4 | 5 |
Table 5 expression confirms to have the result of water gun phenomenon.In table 5, when being illustrated in fluid connection, symbol zero do not see the occasion that produces the water gun phenomenon from mouthful front end that drips, the water gun phenomenon that does not produce when symbol △ is illustrated in fluid connection from mouthful front end that drips, but, if maintenance squeezed state, the number of discharge occasion of dripping slow then, the liquid of symbol * when being illustrated in fluid connection resemble the occasion of discharging the water gun from the mouth that drips.
Table 5
| Sample | Validation test (N=5) | Estimate | Sample | Validation test (N=5) | Estimate | Sample | Validation test (N=5) | Estimate |
| A-1 | ○○○○○ | Be fit to | A-11 | ○○○○△ | Be fit to | A-21 | △○△△○ | Be fit to |
| A-2 | ○○○○○ | Be fit to | A-12 | ○○○○○ | Be fit to | A-22 | ○○○○○ | Be fit to |
| A-3 | ○○○○○ | Be fit to | A-13 | ○○○○○ | Be fit to | A-23 | ○○○○○ | Be fit to |
| B-1 | ○○○○○ | Be fit to | B-11 | ×○×○× | Be not suitable for | B-21 | ××××× | Be not suitable for |
| B-2 | ○○○○○ | Be fit to | B-12 | △○△×○ | Be not suitable for | B-22 | △○○×△ | Be not suitable for |
| B-3 | ○○○○○ | Be fit to | B-13 | ×○○×△ | Be not suitable for | B-23 | ××△×△ | Be not suitable for |
| B-4 | ○○○○○ | Be fit to | B-14 | △△○○○ | Be fit to | B-24 | △×××× | Be not suitable for |
| C-1 | ○○○×○ | Be not suitable for | C-11 | ○××○× | Be not suitable for | C-21 | ××××× | Be not suitable for |
| C-2 | ○×○○○ | Be not suitable for | C-12 | △△×△△ | Be not suitable for | C-22 | ××××× | Be not suitable for |
| C-3 | △○○○○ | Be fit to | C-13 | △△×△△ | Be not suitable for | C-23 | ××××× | Be not suitable for |
As what understand according to table 5, if select aperture 2 μ m, (filtering bodies (Sample A) of 1.5mm * 5=7.5mm) then with to fill liquid measure irrelevant, can prevent the water gun phenomenon to thickness.In addition, if the aperture is 10 μ m (sample B), then filling liquid measure must be at least more than 1.0mL.In addition, be the occasion of 30 μ m (sample C) in the aperture, liquid measure is irrelevant with filling, and produces the water gun phenomenon.
Sampling liquid container of the present invention is not limited to the inspection of the virus of influenza virus etc., can be used for comprising the common biopsy of other pathogen.
Label declaration
Label 1 expression sampling liquid container;
Label 4 expression opening caps;
Claims (20)
1. sampling liquid container, this sampling liquid container comprises the cylindrical container of top and bottom end opening; Retainer and opening cap, so that the dissolving liquid chamber of fluid tightness is set in this cylindrical container inside, this retainer inserts the inside of cylindrical container slidably, this opening is installed on the top of this cylindrical container in mode removably with cap, and this sampling liquid container comprises the breakout box that is installed on the bottom of this cylindrical container with fluid-tight fashion, it is characterized in that, the internal diameter of the bottom of cylindrical container is a bit larger tham the external diameter of retainer, breakout box holds retainer, this retainer is pressed when the dissolving liquid chamber of compressing cylindrical container, between the outside of the bottom of cylindrical container inwall and retainer, form the space, have the mouth of dripping in the bottom in addition.
2. sampling liquid container according to claim 1 is characterized in that, at the inner chamber of above-mentioned breakout box, according to the mode with mouthful adjacency of dripping filtering bodies is set up.
3. sampling liquid container according to claim 1 and 2 is characterized in that the mouth cap of installing in the mode of loading and unloading in the above-mentioned mouthful setting of dripping that drips.
4. sampling liquid container according to claim 1 is characterized in that, further in the top and/or the bottom of sampling liquid container, the auxiliary body that takes out this container is set.
5. sampling liquid container according to claim 4 is characterized in that, the auxiliary body that takes out said vesse is not from the outstanding pinch hand of the outer peripheral face outward direction of sampling liquid container.
6. according to claim 4 or 5 described sampling liquid containers, it is characterized in that the auxiliary body that takes out said vesse is arranged at above-mentioned opening with on the end face of cap.
7. sampling liquid container according to claim 4 is characterized in that, the above-mentioned mouth that drips is for being used for sampling liquid is discharged to the mouth that drips of bottom, and this sampling liquid obtains for sample specimens is imported in the lysate.
8. sampling liquid container according to claim 7 is characterized in that, the above-mentioned mouth that drips is arranged on the breakout box of the bottom that is installed in cylindrical container.
9. sampling liquid container according to claim 7 is characterized in that, at the above-mentioned place of dripping mouthful the mouth cap that drips is set, and the auxiliary body of taking-up said vesse is set on this drips mouthful with cap.
10. sampling liquid container according to claim 9 is characterized in that, above-mentioned opening with cap and/or drip mouthful with cap end face have top board and with the continuous and vertically disposed perisporium of this top board, the jog of anti-skidding usefulness is set on the outer peripheral face of this perisporium.
11. sampling liquid container according to claim 1 is characterized in that, in the inside of above-mentioned cylindrical container, is provided for promoting the inside at above-mentioned dissolving liquid chamber, the dissolving of sample specimens or the auxiliary body of extraction.
12. sampling liquid container according to claim 11, it is characterized in that, be used to promote that the dissolving of above-mentioned sample specimens or the auxiliary body of extraction are separates walls, this separates walls is according to making cylindrical container interior side-prominent, and forms in the mode that pars intermedia is offered the through hole that inserts for cotton swab.
13. sampling liquid container according to claim 12 is characterized in that, above-mentioned separates walls is to be arranged on the inwall of above-mentioned cylindrical container, vertically the circular protrusion that is provided with continuously.
14. sampling liquid container according to claim 12 is characterized in that, above-mentioned separates walls is the spiral helicine projection that is arranged on the inwall of above-mentioned cylindrical container.
15. sampling liquid container according to claim 12 is characterized in that, above-mentioned separates walls is with the isolated projection of prescribed distance on the inwall of above-mentioned cylindrical container.
16. sampling liquid container according to claim 11, it is characterized in that, the auxiliary body that is used to promote the dissolving of above-mentioned sample specimens or extraction comprises from the bottom of above-mentioned cylindrical container a plurality of post portion of stretching out towards the direction on top, top, top in this post portion radially has the projection of beam.
17. sampling liquid container according to claim 1, it is characterized in that, in the inner cylinder portion of above-mentioned breakout box, according to mode filtering bodies is set with mouthful adjacency of dripping, this filtering bodies is continuous poriferous plastid, wherein, the aperture is in the scope of 0.1～20 μ m, and thickness is in the scope of 1.0～6.0mm.
18. sampling liquid container according to claim 1 is characterized in that, the above-mentioned mouth that drips has bore in the scope of 0.5～2mm, the hollow groove of length in the scope of 6～15mm.
19. sampling liquid container according to claim 1 is characterized in that, the amount that is filled in the lysate in the above-mentioned dissolving liquid chamber is in the scope of 0.1～2.0mL.
20. sampling liquid container according to claim 1 is characterized in that, above-mentioned filtering bodies is sintered body, shaping foam element, nonwoven fabrics or superimposed fiber body.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP070840/2005 | 2005-03-14 | ||
| JP2005070840A JP4492396B2 (en) | 2005-03-14 | 2005-03-14 | Sample collection liquid container |
| JP220025/2005 | 2005-07-29 | ||
| JP259045/2005 | 2005-09-07 | ||
| JP001557/2006 | 2006-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101137895A true CN101137895A (en) | 2008-03-05 |
Family
ID=37091522
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800079712A Pending CN101137895A (en) | 2005-03-14 | 2006-03-14 | Sampling liquid container |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4492396B2 (en) |
| CN (1) | CN101137895A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111656156A (en) * | 2018-01-30 | 2020-09-11 | 善肴控股株式会社 | Method for trapping microorganism and gene and method for extracting the same |
| CN111889152A (en) * | 2020-07-31 | 2020-11-06 | 珠海市人民医院 | Reaction reagent bottle |
| CN112014141A (en) * | 2020-07-31 | 2020-12-01 | 珠海市人民医院 | Sampling reaction method |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5265492B2 (en) * | 2009-09-28 | 2013-08-14 | 栄研化学株式会社 | Wiping device for environmental microbiological examination |
| JP2012021953A (en) * | 2010-07-16 | 2012-02-02 | Mk Medical Co Ltd | Flock brush inspection kit and method for inspection for wiping-off using the same |
| JP6344794B2 (en) * | 2014-08-20 | 2018-06-20 | 株式会社佐藤アンプル製作所 | Sample testing tool |
| JP2020524789A (en) * | 2017-06-21 | 2020-08-20 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ | A compressible extraction device for sample preparation |
| CN108871908A (en) * | 2018-09-06 | 2018-11-23 | 杭州优思达生物技术有限公司 | Biological sample processing unit |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03107824U (en) * | 1990-02-22 | 1991-11-06 | ||
| JP3487685B2 (en) * | 1995-04-24 | 2004-01-19 | 積水化学工業株式会社 | Fecal occult blood determination device |
| AT404317B (en) * | 1996-08-02 | 1998-10-27 | Greiner & Soehne C A | LOCKING DEVICE, DISCONNECTING DEVICE AND RECEIVING CONTAINER FOR A RECEIVING DEVICE |
| JP3814395B2 (en) * | 1997-12-17 | 2006-08-30 | 勝恒 佐藤 | Sample collection device |
| JP3719572B2 (en) * | 1997-12-19 | 2005-11-24 | 栄研器材株式会社 | Sample collection container for environmental health inspection |
| JP4123401B2 (en) * | 1999-01-05 | 2008-07-23 | 栄研化学株式会社 | Examination container, sample specimen collection method and stool collection container |
| JP2001116739A (en) * | 1999-08-06 | 2001-04-27 | Sekisui Chem Co Ltd | Instrument for inspection |
| JP4091350B2 (en) * | 2001-10-01 | 2008-05-28 | 株式会社トーメー | Liquid dripping container |
-
2005
- 2005-03-14 JP JP2005070840A patent/JP4492396B2/en not_active Expired - Fee Related
-
2006
- 2006-03-14 CN CNA2006800079712A patent/CN101137895A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111656156A (en) * | 2018-01-30 | 2020-09-11 | 善肴控股株式会社 | Method for trapping microorganism and gene and method for extracting the same |
| CN111889152A (en) * | 2020-07-31 | 2020-11-06 | 珠海市人民医院 | Reaction reagent bottle |
| CN112014141A (en) * | 2020-07-31 | 2020-12-01 | 珠海市人民医院 | Sampling reaction method |
| CN111889152B (en) * | 2020-07-31 | 2022-04-08 | 珠海市人民医院 | Reaction reagent bottle |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006250860A (en) | 2006-09-21 |
| JP4492396B2 (en) | 2010-06-30 |
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