CN101087617A

CN101087617A - Method and material for curing wound, burn and skin disease

Info

Publication number: CN101087617A
Application number: CN 200580044672
Authority: CN
Inventors: J·加贝
Original assignee: Cupron Corp
Current assignee: Cupron Corp
Priority date: 2004-11-07
Filing date: 2005-11-07
Publication date: 2007-12-12
Also published as: ZA200703628B; IL165064A0

Abstract

The invention provides a treatment method for sore, common cold sore, skin breach, ulcer, damage, abrasion, burn, and dermatosis, which includes coating material containing water-fast copper compound on the skin, wherein, the compound releases Cu+ ion, Cu++ ion, or the two ions when connects to fluid.

Description

Treatment wound, burn and dermopathic method and material

Invention field

The present invention relates to treat skin ulcer, cold sore, skin openings, ulcer, scratch, infringement, burn and dermopathic method and relate to the application of material in treatment skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis of having mixed the water-insoluble copper compound.

More particularly, the present invention relates to treat skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic method, comprise it is used the Wound healing and bone regeneration material, mixed release Cu when contacting with fluid in this material ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

The invention still further relates to and when contacting with fluid, discharge Cu ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination this class of preparation such as fabric or cast film, silk or sheath contact have skin ulcer, scratch, ulcer, infringement, skin openings, burn and dermopathic body surface so as it to be treated and the material that heals in application.Described sheath or cast film can have novel monolithic layer, and this layer has except that moisture performance or micropore.

In addition, the particulate thin polymer film of microcosmic water-insoluble that the present invention relates to have the ionic oxide formation copper of powder type is used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic binder in preparation, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

Similarly, the present invention relates to mix release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic binder in preparation.

As described below, in a preferred embodiment of the invention, described fiber is to have to mix wherein and the polymer fiber of the described chemical compound that its surface is outstanding.

As described below, in other preferred embodiment of the present invention, applied described copper compound on the described fiber.

In other preferred embodiment of the present invention, described material is made of component of polymer, described component of polymer is selected from polyamide, polyester, acrylic acid and poly-olefin(e), can also comprise that described material is the form of fiber, yarn or sheet such as polypropylene, polyurethanes, polyolefin, polyethylene and other hydrophilic and this class material of hydrophobic polymer.

Just seeing below that embodiment and accompanying drawing describe, finding unexpectedly at present and can discharge Cu when the contacting with fluid having mixed ⁺Ion, Cu ⁺⁺The material of the water-insoluble copper compound of ion or its combination is used to produce fabric, thin film, silk or sheath, and their contacts have such as skin ulcer cold sore, skin openings, ulcer, infringement, comprise vascular lesion and mucosal injury, scratch, burn and dermopathic body surface are so that make its healing.

More particularly, material of the present invention effectively heal ulcer skin ulcer and/or infringement have been found at present unexpectedly, such as those skin ulcers, decubital ulcer, burn, acne, the herpes sore that cause because of diabetes, and effectively healing and antibacterial, fungus or the relevant dermatosis of virus, such as eczema, psoriasis, herpes etc.

In addition, material of the present invention can be used for the treatment of hello newborn women's nipple skin ulcer and scratch skin ulcer and the infringement on amputee's part limbs.Can also use material treatment decubital ulcer of the present invention.Can use suture material wound closure and the surgical openings made by material of the present invention, and because also find as for example hereinafter material of the present invention as shown in the embodiment 7 help wound healing and preventing from scar, be other operation of a factor so suture material of the present invention is particularly useful for the plastic surgery with aesthetics.

Background of invention

Instructed to have directly or the different aspect of the fabric of the metal wholly or in part of its fiber of strong bonded or metal oxide coating in WO 98/06508 and WO 98/06509, wherein metal and metal-oxide comprise that copper combines with described fiber.

More particularly, in WO 98/06509, provide the method that comprises the following steps: the fabric that plating (a) is provided, the fabric of this plating comprises: (i) comprise the fabric of fiber, described fiber is selected from natural fiber, synthetic cellulose fibres, regenerated fiber, acrylic fiber, polyolefine fiber, polyurethane fibre, vinyl fiber and admixture thereof; The coating that (ii) comprises the material that is selected from metal and metal-oxide, the fabric of plating are characterised in that coating directly combines with fiber; (b) fabric with plating mixes goods.

In the context of the present invention, term " fabric " comprising: no matter fiber is natural (for example Cotton Gossypii, silk thread, Pilus Caprae seu Ovis and linen), still is by the synthetic threads of those fibre spinnings; With knitting, braiding of making and non-woven fabric by those yarns.Scope of the present invention comprises all natural fibers and all synthetic fibers that are used for fabric applications, and including, but are not limited to synthetic cellulose fibres (is regenerated celulose fibre, such as artificial silk; And cellulose derivative fibres, such as typel); Azlon; Acrylic fiber; Polyolefine fiber; Polyurethane fibre; And vinyl fiber, but do not comprise nylon and polyester fiber and admixture thereof.

Present invention resides in the application of product of technological improvement of the metallide of the plastics that are used for containing metal, the printed circuit board (PCB) that particularly is made of plastics.For example, referring to Bncyclopediaof Polymer Science and Bngineering (Jacqueline I.Kroschwitz, editor), Wiley and Sons, 1987, vol.IX, pp 580-598.As the application in fabric, this method comprised for two steps.The first step is by making catalytic precious metal nucleation site be deposited in activated textile on the fabric.This step is by at first immersing fabric low-oxidation-state Reducing agent cationic solution and then this fabric being immersed precious metal cation solution, preferred Pd++ cationic solution, most preferably acid PdCl ₂Carry out in the solution.Low-oxidation-state cation is reduced into noble metal self with precious metal cation, is oxidized to higher oxidation state simultaneously.Preferred Reducing agent cation is a soluble cation under initial low-oxidation-state and final high oxidation state, and for example, Sn++ is oxidized to Sn++++, or Ti+++ is oxidized to Ti++++.

Second step was reduction, and promptly closely near activatory fabric reducing metal cation, it reduces by precious metal catalyst.The cationic Reducing agent that is used to reduce is generally molecular species, for example, with regard to Cu++, is formaldehyde.Because Reducing agent is oxidized, so metal cation is called " oxidant cations " in this article.The fabric of consequent plating is characterised in that its coat of metal directly combines with fabric fibre.

In WO 98/06508, describe and asked for protection a kind of composition of matter, comprising:

(a) comprise the fabric of fiber, described fiber is selected from natural fiber, synthetic cellulose fibres, azlon, acrylic fiber, polyolefine fiber, polyurethane fibre, vinyl fiber and admixture thereof; With

(b) comprise the coating of the material that is selected from metal and metal-oxide;

This composition of matter is characterised in that described coating directly combines with described fiber.

The disclosure document is also asked for protection a kind of composition of matter, comprising:

(b) a plurality of nucleation site, described nucleation site comprises at least a noble metal separately;

This composition of matter is characterised in that the reduction of at least a metal cation kind of catalysis, makes into reductive metal, plates described reductive metal for thus described fiber.

In addition, instruct and asked for protection the method that is used to produce described product in the disclosure document.

The method for optimizing of fabric that is used for preparing the plating of the disclosure document comprises the following steps:

A) select a kind of fabric, its form is selected from yarn and fabric, described fabric comprises fiber, and described fiber is selected from natural fiber, synthetic cellulose fibres, azlon, acrylic fiber, polyolefine fiber, polyurethane fibre, vinyl fiber and admixture thereof;

B) described fabric immersion is contained at least a solution with Reducing agent cation type of at least two kinds of positive oxidation state, described at least a cation type is the low form at least two kinds of positive oxidation state;

C) described fabric is immersed the solution that contains at least a precious metal cation kind, produce activatory fabric thus; With

D) at least a oxidant cations kind of reduction in the medium of the described activatory fabric of contact produces the fabric of plating thus.

Yet, the disclosure document is limited to fiber and the fabric according to the coating that is used for application as herein described of the preparation of the method described in the literary composition, but, do not instruct or point out the fiber of this class coating and fabric can treat effectively and heal as described herein and be typical skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis in the disclosure document with this paper.

Similarly, in the disclosure document the instruction or the prompting cation copper is mixed in the polymer slurries of hydrophobic polymer, have with production and to be encapsulated in the described polymer and from the thin film of the microscopic particles of wherein outstanding cation copper and the probability of fiber, the present invention finds that unexpectedly they can also treat effectively and heal as described herein and be typical skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis with this paper.

According to the description among the USSN 10/240993, discovery is added in the polymer slurries to be formed by the Cu++ with the little percentage ratio of water-insoluble copper oxide particle form, resulting polymers has antimicrobial property, and the content that the document is instructed is incorporated herein by reference.

In addition, this article is found unexpectedly and has been described by the copper oxide with particle form and joins such as polyethylene, polypropylene, polyesters with similarly in the polymer slurries of hydrophobicity or this base polymer of hydrophilic polymer material, can have the antimicrobial of extensive use and fiber, yarn or the sheet of ntiviral characteristic by extrusion molding.The application that new antimicrobial of describing in to described description and antiviral polymeric material are paid close attention to is: its application in the carpet backing layer, even can be used for hospital facility, because can not producing mycete, abnormal smells from the patient and can make, it is not deposited in any virally inactivated on it; As the application of the composition of molded non-knitting product, maybe can see through air such as the air filter in hospital or the aircraft and maybe can see through liquid and can be used for filtering the fluid of circulation and make antibacterial that described fluid finds and virally inactivated face shield; Form continuous, open and flat, texture or tensile form are arranged, it can be used for clothes product, such as stocking, socks, shirt or any clothes product that can mix hydrophobic polymer fiber or yarn; Form short use subsequently, or can with other fiber, such as the staple fiber of Cotton Gossypii fusion, the yarn of fusion can be used to produce various braidings or knit product then, such as socks, sheet etc.; With of the application of this class with the polymeric material of two composition form of yarns productions, wherein core is that a kind of chemical compound and the sheath around core are the polymer that contains the insoluble shape copper oxide particle of water, thereby produce the yarn of numerous intended application, it is staple fiber continuous, open and flat, that texture, stretchable form or conduct weak point are arranged.The example that use described back one can be the application of polyethylene core in forming yarn with the polymer jacket that has mixed described water-insoluble copper oxide particle, described yarn has the enhanced anti-drag that is cut or tears, also have antimicrobial and ntiviral characteristic simultaneously and have multiple application, be included in Application in Food Industry.

Described material is described as being made by any synthetic polymer, and this polymer allows cationic, oxidized copper granule is introduced its liquid slurry state.The example of some material is that polyamide-based (nylon), polyester, acrylic acid and polyene belong to hydro carbons, such as polyethylene and polypropylene.When cupric oxide powder is ground to form fine powder, for example size is at the 1-10 micron and with a small amount of introducing slurry, for example, as acceptable when being used for masterbatch that production extruded fibers and thin film implement and accounting for the amount of polymer weight 0.25-10%, find subsequently to show antimicrobial and ntiviral characteristic by the product of this slurry production.

Be different from for example at the fiber described in WO 98/06508 and the WO 98/06509, wherein the fiber outside is coated, in described product, polymer has the microcosmic water-insoluble granule of the cationic oxidation copper that is encapsulated in wherein, and wherein the described granule of part exposes and be outstanding from its surface.Verified these granules from the outstanding exposure of polymer material membrane have activity, as the training centre confirmation by test and this description described in the described description, because they are related to the present invention, so be introduced into this paper as a reference.

Yet, do not instruct in the described US description yet or point out polymeric material as herein described can effectively treat and heal as described herein and be typical skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis with this paper.

Generally speaking, the product in the described description and can be used for product of the present invention and produce as follows:

1. by polymer manufacture slurry arbitrarily, primary raw material is preferably from polyamide, poly-olefin(e), polyurethanes and polyester.Can also use in the described material more than one combination, as long as they have the compatibility and maybe can be adjusted into the compatibility.Polymer raw material is generally the form of pearl and in fact can be single composition, two composition or multicomponent.These pearls are heated to preferably under about 120-180 ℃ temperature, melt.

2. at hot mix stages, before extrusion molding, join the water-insoluble powder of cationic oxidation copper in the described slurry and it is fully distributed in the slurry of whole heating.Granular size is preferably at the 1-10 micron, and but, when thin film or fiber thickness can hold larger particles, described size can be bigger.

3. push liquid slurry by forming circle or being called hole on a series of metal plates of other required form of spinning head with pressure then.When pushing slurry when the approximating pore, they form ultimate fibre, if or they are contacted with each other, their formation thin film or sheaths so.Use cold air upwards to push hot liquid fiber or thin film, form the fiber or the circular piece of continuous series.Upwards push the speed controlling fiber of slurry or the thickness of sheet according to the size in hole with by the hole with by thin cooling blast.

The antimicrobial compositions that comprises particles of inorganic material has been described in WO 94/15463; described particles of inorganic material has first coating that antimicrobial property is provided and second coating that defencive function is provided; wherein said first coating can be the chemical compound of silver or copper or silver, copper and zinc, and preferably contains the chemical compound of silver oxide and copper oxide (II).Yet; this patent is based on complicated and expensive method; this method comprises with the second protective finish plating compositions; described second protective finish is selected from silicon dioxide, silicate, borosilicate, aluminium silicate salt, aluminium oxide, aluminum phosphate or its mixture; and in fact all claim all relates to and has continuous coated compositions, wraps described coating and draws together silicon dioxide, aqueous alumina and dioctyl azelate.

On the contrary, The present invention be more particularly directed to have the application of the particulate thin polymer film of microcosmic water-insoluble of the cationic oxidation copper of powder type, described particle release is encapsulated in Cu wherein ⁺⁺, wherein the described granule of part exposes and is outstanding from its surface, and this characteristic is instruction in described open source literature, also prompting, and the present invention has following advantage: confirmed the release Cu that exposes ⁺⁺Outstanding water-insoluble granule from polymeric material can be effective to the healing of open wound.

A kind of bactericidal composition has been described in EP 427858, it is characterized in that having applied on the fine inorganic particles antibacterial metal and/or antisepsis metallic compound, and this patent is instructed not also or point out the particulate polymer of microcosmic water-insoluble of the cationic oxidation copper that has mixed powder type can discharge the Cu that is encapsulated in wherein ⁺⁺, wherein the described granule of part exposes and is outstanding from its surface.

Use and ion Cu have been described in DE 4403016 ⁺⁺The sterilization of opposite copper and Fungicidal composition, and this patent is not instructed or point out the particulate polymer of microcosmic water-insoluble of the cationic oxidation copper that has mixed powder type can discharge the Cu that is encapsulated in wherein ⁺⁺, wherein the described granule of part exposes and is outstanding from its surface.

Described the release of the using metal ionic condom that sterilizes in JP-01046465, described metal is selected from copper, silver, hydrargyrum and alloy thereof, and these metals have sterilization and kill and wound the effect of sperm, and wherein said metal is preferably micronization copper.As is known, although also mentioned mantoquita, such as copper chloride, copper sulfate and copper nitrate, they are water soluble salt, can dissolve and decompose the polymer of introducing them.Similarly, although mentioned Red copper oxide, Cu especially ⁺⁺Ionic species, and therefore the release Cu of exposure is not instructed or pointed out to described patent ⁺⁺The outstanding and verified particulate application of water-insoluble that is effective to the open wound healing from polymeric material.

Described a kind of antimicrobial molded products in JP-01246204, wherein the mixture of powdery copper compound and organopolysiloxane is dispensed into thermoplastic molded goods so that prepare cloth, socks etc.This patent mentions especially and has instructed and metal ion self can not have been introduced polymer molecule and need be comprised organopolysiloxane that it also can provide the connection approach that copper ion is released into fiber surface.Therefore, as cognoscible, described copper compound can be encapsulated, but the release Cu of exposure is not instructed or pointed out to this patent ⁺⁺The application of outstanding water-insoluble copper oxide particle from polymeric material.

The fiber that is preferred for producing underwear with good resistance fungus and health effect has been described in JP-03113011, wherein said synthetic fibers contain copper or copper compound and germanium or its combination of compounds, but, the germanium of the existence that this patent instruction and requirement expose therein and the major part of copper compound are preferably metallic copper, are monovalence Cu ⁺The Hydro-Giene (Water Science). of chemical compound and water solublity mantoquita.Therefore, the release Cu of exposure is not instructed or pointed out to this patent ⁺⁺The application of outstanding water-insoluble copper oxide particle from polymeric material.

In EP 116865, describe and asked for protection the polymer product that contains zeolite granular, wherein to small part kept at least a have the metal ion of antibacterial attribute and thus this patent do not instruct or point out the release Cu of exposure ⁺⁺Water-insoluble copper oxide particle self and in the application that does not have in the presence of the zeolite, described granule is the outstanding and verified healing that can be used for open wound effectively from polymeric material.

Describe and asked for protection the polymer that contains amorphism silicic acid alumina particles among the BP 253653; the amorphism silicic acid aluminum solid particle that described granule includes organic polymer and amorphism silicic acid aluminum solid particle or handles with coating reagent, in the described amorphism silicic acid aluminum solid particle some maintains the metal ion with bactericidal action at least.Therefore, the release Cu of exposure is not instructed or pointed out to this patent ⁺⁺Water-insoluble copper oxide particle self and in the application that does not have in the presence of the amorphism silicic acid alumina particles, the release Cu of exposure ⁺⁺The outstanding and verified healing that is effective to open wound from polymeric material of water-insoluble copper oxide particle.

Therefore, there is not one piece to instruct or pointed out release Cu when contacting with fluid in the described open source literature ⁺Ion, Cu ⁺⁺The application of the water-insoluble copper compound of ion or its combination in preparation fabric or cast film, silk or sheath, described fabric or cast film, silk or sheath contact has skin ulcer, scratch, ulcer, infringement, skin openings, burn and dermopathic body surface so that it is treated and heals.

Summary of the invention

Therefore, relate in the preferred aspect of the present invention and having mixed at contacting with fluid discharging Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic binder in preparation.

In the preferred embodiment of the present invention aspect this, described binder is made of the gauze material that has wherein mixed described copper compound.

The particulate thin polymer film of microcosmic water-insoluble that second preferred aspect of the present invention relates to the ionic oxide formation copper with powder type is used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic binder in preparation, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In the preferred embodiment aspect second of the present invention, described fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

In the present invention's other preferred embodiment aspect this, applied described copper compound on the described fiber.

The 3rd preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the application of patient's clothing of hospital and health-care facilities in preparation, described hospital and health care facilities such as home care chamber, senior citizen reside institute, long-term care facility, rehabilitation center and hospice, so that the prevention decubital ulcer forms, if and form, then treat this class skin ulcer.

As known, such as invalid and chronic disease this class patient and be limited to for a long time among the gerontal patient of sick bed or wheelchair, extruding skin ulcer (pressure sores) and decubital ulcer (bed sores) cause life-threatening complication usually.

Therefore, according to the present invention, discharge Cu when the contacting with fluid by being provided at least to have mixed with the contiguous place of patient's seat area ⁺Ion, Cu ⁺⁺The medicated clothing of the water-insoluble copper compound of ion or its combination, such as nightwear, women's nightwear and underwear, can prevent or initial period of this class skin ulcer to its healing performance immediate effect.

More particularly, this aspect of the present invention also relates to release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination is used for the application such as the medicated clothing of nightwear, women's nightwear and underwear of patient's clothing of hospital and health care facilities in preparation, described medicated clothing has the cloth sheet that mixes in contiguous patient's seat area at least, and described cloth sheet is included in and discharges Cu when fluid is mixed in contact ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination is with prevention and healing decubital ulcer and extruding skin ulcer.

It is to be further understood that vicinity that material of the present invention can also be incorporated into described medicated clothing forms these other zones in other zone of health of extruding skin ulcer easily.

In addition, aspect this 3rd of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The particulate thin polymer film of microcosmic water-insoluble that the 4th preferred aspect of the present invention relates to the ionic oxide formation copper with powder type the preparation body limbs with protective jacket so that treat application in the skin ulcer that forms on it, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

The 5th preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination the preparation body limbs with protective jacket so that treat application in the skin ulcer that forms on it.

In addition, aspect this 5th of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The 6th preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The application of the fiber of the water-insoluble copper compound of ion or its combination in being used for the treatment of skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic dressing.

In addition, aspect this 6th of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The 7th preferred aspect of the present invention relates to the application of the particulate thin polymer film of microcosmic water-insoluble in preparation treatment skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic dressing of the ionic oxide formation copper with powder type, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

The 8th preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in the underwear of male genital organ herpes sore outburst in preparation.

In addition, aspect this 8th of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The 9th preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of the medicated bra of feeding wet nurse parent usefulness of nipple skin ulcer and the application in the nursing pad in preparation.

In addition, aspect this 9th of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The of the present invention ten preferred aspect relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in the dressing of acne in preparation.

In addition, aspect this tenth of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

In the especially preferred embodiment aspect this tenth of the present invention, described fiber is mixed the elastic bandage pad of filling.

The 11 preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is subjected to the body surface of psoriasis infringement so that the application in the fabric that it is treated in the preparation contact.

In addition, aspect this 11 of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The 12 preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is subjected to the body surface of eczema infringement so that the application in the fabric that it is treated in the preparation contact.

In addition, aspect this 12 of the present invention in, described fiber is preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

The 13 preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination preparation contact have skin ulcer, scratch, burn and dermopathic body surface so as it to be treated and the fabric that heals in application.

The 14 preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The application of the fiber of the water-insoluble copper compound of ion or its combination in the preparation suture material.

The 15 preferred aspect of the present invention relates to the application of the particulate polymer filament of microcosmic water-insoluble in the preparation suture material of the ionic oxide formation copper with powder type, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

The 16 preferred aspect of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination is used for the application of the wound healing fabric of army's uniform or underwear or coat goods in preparation, described fabric comprises and entering when dressing its wound of military staff in spite of wound, can obtain the antibacterial effect of described wound and the fiber of healing effect.

This embodiment preferred of the present invention relates to has mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the application of the wound healing fabric of army's uniform or underwear or coat goods in preparation, when described fiber enters the military staff's in spite of wound who dresses it wound, can obtain antibacterial effect and healing effect to described wound.

In addition, in the present invention was aspect this, described fiber was preferably and has wherein mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface, or has applied described copper compound on the described fiber.

As known, for the problem of army's existence be when the military staff for example because of emitting substance, shrapnel and blast when injured, be driven into the wound of generation the uniform that fiber is dressed from them usually or underwear or the coat goods and they self also can become the source of infection.Therefore, above-mentioned aspect of the present invention is by provide uniform and underwear or coat goods to solve this problem to the military staff, when its wearer was unfortunate injured, these products not only can bring into play antibacterial action so that prevention infection, and can initiatively promote the healing of wound.

The additional application of material of the present invention is to form the plasticity wadding.

Another aspect of the present invention provides the treatment skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic method, comprise the polymeric material that constitutes by component of polymer using on it, described component of polymer is selected from polyamide, polyester, acrylic acid and poly-olefin(e), described material is a fiber, yarn, sheath, the form of silk or sheet, and microcosmic water-insoluble granule with ionic oxide formation copper of powder type, described granule directly is embedded in the polymeric material, wherein the described granule of part exposes and is outstanding from its surface, and these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

Another embodiment preferred of the present invention provides the method for prevent diabetes granuloma, infringement and ulcer, comprises that the material that will mix the water-insoluble copper compound is applied to the protected area, and described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

Another preferred aspect of the present invention provides the method for prevent diabetes granuloma, infringement and ulcer; comprise and to use the protected area by the polymeric material that component of polymer constitutes; described component of polymer is selected from polyamide, polyester, acrylic acid and poly-olefin(e); described material is the form of fiber, yarn, sheath, silk or sheet; and microcosmic water-insoluble granule with ionic oxide formation copper of powder type; directly be embedded with the described granule that part exposes and give prominence to from its surface in the described material, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In the especially preferred embodiment of the present invention aspect this, described material is the fabric with the fiber that has mixed the water-insoluble copper compound, and described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

As described, the present invention relates to treatment and healing skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic method, comprise the body surface that shows these situations is used the material that mixed the water-insoluble copper compound so that it is treated and heals, described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In first embodiment preferred, described skin ulcer is the ulcer skin ulcer.

In second embodiment preferred, described skin ulcer is a decubital ulcer.

In an especially preferred embodiment, the ulcer skin ulcer of described skin ulcer for causing because of diabetes.

In another preferred embodiment, described infringement is a vascular lesion.

In another preferred embodiment, described infringement is a mucosal injury.

In first group of embodiment preferred of the present invention, described material discharges Cu when the contacting with fluid for having to have mixed ⁺Ion, Cu ⁺⁺The fabric of the fiber of the water-insoluble copper compound of ion or its combination.

In second group of embodiment preferred of the present invention, described material is the particulate thin polymer film of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In the 3rd group of embodiment preferred of the present invention, described material is the particulate polymer fiber of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In the 4th group of embodiment preferred of the present invention, described material is the particulate polymer filament of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In the 5th group of embodiment preferred of the present invention, described material is the particulate polymer jacket of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

In the 6th group of embodiment preferred of the present invention, described material is the particulate thin polymer film of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination, wherein said thin film has the ability by the infiltration dispersing liquid.

In the 7th group of embodiment preferred of the present invention, described material is the particulate thin polymer film of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination spreads all over the micropore that runs through so that excessive liquid is discharged on the wherein said thin film.

As mentioned above, based on the unexpected discovery of the present invention, promptly mixed release Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The material of the water-insoluble copper compound of ion or its combination can be used for the treatment of and heal skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic method, so that used the surface that the treatment of described material and healing are encroached on, have realized that at present method of the present invention can effectively treat numerous disease by this class encroaching on body surface.

Therefore, the invention provides the method for treatment male genital organ herpes sore outburst, comprise the underwear with the fiber that has mixed the water-insoluble copper compound is provided that described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

The present invention also provides the method for treatment acne, comprises it is used the fabric with the fiber that has mixed the water-insoluble copper compound that described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

Similarly, the invention provides the method that newborn women's body surface nipple skin ulcer is fed in treatment, comprise medicated bra or the nursing pad with fiber is provided, mixed release Cu when contacting with fluid in the described fiber ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

In addition, the invention provides the method for treatment burn, comprise the wound healing fabric that is applied to described burn surfaces or the wound healing thin film or the silk of extrusion molding are provided, wherein mixed and when contacting with fluid, discharge Cu ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

Can produce through the following steps and be used for polymeric material of the present invention: the preparation polymer slurries, described polymer is selected from polyamide, polyester, acrylic acid and poly-olefin(e) and composition thereof; Introduce mainly the powder that becomes by water-insoluble cationic oxidation copper group and make it be dispersed in the described slurry and then the described slurry of extrusion molding wherein discharge Cu so that form polymeric material ⁺Ion, Cu ⁺⁺The water-insoluble copper oxide particle of ion or its combination is encapsulated in wherein, wherein the described granule of part exposes and is outstanding from its surface, make this polymeric material form fiber, yarn or sheet then in case make be suitable for contacting have skin ulcer, scratch, burn and dermopathic body surface and treat and their fabric of healing.

At US 6; 124; describe and asked for protection clothes product in 221 with antibiotic, antifungal and anti-yeast character; the fabric that comprises at least one block of plating; this fabric comprises fiber; described fiber is selected from natural fiber, synthetic cellulose fibres, azlon, acrylic fiber, polyolefine fiber, polyurethane fibre, vinyl fiber and admixture thereof, and has the oxidant cations kind coating of at least a copper that comprises antibiotic, antifungal and anti-yeast effective dose.

Having described described clothes product in described description can effectively anti-tinea pedis (TineaPedis), white candida mycoderma (Candida Albicans), thrush (Thrush) and the antibacterial that causes the foot abnormal smells from the patient, be selected from brevibacterium (brevubacterium), acinetobacter (acinetobacter), Micrococcus (micrococCus) and combination thereof, yet, described patent is not instructed or is pointed out the plan application of this class clothes product or can effectively treat wound, such as skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis.

The textile of having described the fiber of the cationic form that has mixed copper coated in WO 01/81671 also can effectively make the antibiotic resistance strain inactivation of antibacterial, and the cation type of described copper preferably comprises Cu ⁺⁺Ion, yet, in addition in this description, described and be used to handle hospital environment so that by making excretory this bacterioid inactivation of infected patient come the textile of prevention infection diffusion, and in this description not the clothes product that constitutes by this class textile of instruction or prompting can effectively treat wound, such as skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis.

Describe and asked for protection release Cu among the WO 01/74166 ⁺⁺The application of ionic granule in the preparation polymeric material, described polymeric material has and discharges the microscopic particles be encapsulated in wherein, wherein the described granule of part exposes and is outstanding from its surface, described polymeric material effectively suppresses HIV-1 propagation, yet, the disclosure document is limited to the application of this base polymer material of instruction in preparation condom and possible glove, and its inventor do not recognize at that time and the disclosure document in also not the instruction or the prompting the invention provides the design that can effectively treat the clothes product of wound, described wound is such as skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermatosis.

The air filter or the water filter of the copper metal, copper oxide, chloride, carbonate and the sulfate that comprise anti-poisonous steam and gas and antibacterium and virus in US 5848592, US 5492882, FR 2764518, GB 1382820 and US 5217626, have been disclosed separately.With regard to GB1382820, disclosed the pneumatic filter that has mixed active carbon and/or one or more high molecular metal-oxides or multiple oxide, so that go down to posterity with physics mode blocking-up and pre-bacteriological protection.With regard to US 5215626, disclosed and mixed permanganate compounds, silver compound and water-soluble copper compound, such as the water strainer of the mixture of copper chloride or copper sulfate.

Yet none instruction or prompting have been mixed and discharged Cu when contacting with fluid in the described list of references ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination preparation contact have skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic body surface so as it to be treated and the fabric that heals in application.

DATABASE WPI Section Ch, Week 199031 Derwent PublicationsLtd .London, GB; Class B04, An 1990-234808 XP002247181 ﹠amp; JP02 161954 and DATABASE WPI Section Ch, Week 198821 DerwentPublications Ltd .London, GB; Class A88, An 1988-145060XP002247182 ﹠amp; JP 631088007 relates to the hollow porous fibre, and has especially disclosed with the bonded cuprammonium treatment of cellulose body fluid among the JP631088007, yet, both not instructions in the described list of references, also release Cu when contacting with fluid has not been mixed in prompting ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination preparation contact have skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic body surface so as it to be treated and the fabric that heals in application.

As mentioned above, instruction and asked for protection antimicrobial and antiviral polymeric material among the WO 01/74166, it has and discharges the Cu that is encapsulated in wherein ⁺⁺Ion and the microscopic particles of giving prominence to from its surface, but do not instruct or point out method of the present invention in the document.Similarly; WO01/81671 instruction and the method for having asked for protection opposing and having prevented nosocomial infection; comprise the textile that health care facilities is provided the fiber of the cationic form that has mixed copper coated; wherein said textile can effectively make the antibiotic resistance strain inactivation of antibacterial, but release Cu when contacting with fluid has not been mixed in instruction or prompting yet in the document ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination preparation contact have skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic body surface so as it to be treated and the fabric that heals in application.

Therefore, none instruction or pointed out theme of the present invention in the above-mentioned open source literature.

In the method for the invention, the cation type of copper must the contact liq medium so that can make atomic dispersion go into medium, no matter described medium is the body fluid from open wound, skin ulcer or burn, as the perspire that the carrier of described atomic dispersion works, still join in fiber or the fabric so that promote the liquid or the surfactant of ion-transfer to skin ulcer, scratch or burn position.

Has the Cu of being selected from order to form wound of the present invention-treatment material, can preferably to adopt ⁺And Cu ⁺⁺The fiber of ionic ion copper, and they are included in the substrate.In a kind of knitting substrate, fiber can be with any other fiber fusion and by knitting or be woven into substrate.In the non-knitting structure, fiber can be blended into thin layer.In both of these case, can preferably multilamellar be placed another layer top so that form pad.

According to the similar mode and combine the ion copper that hereinafter described moderate modification preparation is used for the inventive method described in the description formerly of above-mentioned reference, and by on the substrate or the acquisition of the redox reaction in liquid separately.This production method is the plastics electroless plating coating that conduct is used to contain metal, the improvement of the technology of the printed circuit board (PCB) that particularly is made of plastics.For example, referring to Encyclopedia of Polymer Science and Engineering (Jacqueline I.Kroschwitz, editor), Wiley and Sons, 1987, vol.IX, pp 580-598.As the application in fiber or fabric or film, this method comprised for two steps.The first step is for to activate substrate by catalytic precious metal nucleation site is deposited on the substrate surface.This step is by at first immersing substrate low-oxidation-state Reducing agent cationic solution and then this substrate being immersed precious metal cation solution, preferred Pd++ cationic solution, most preferably acid PdCl ₂Carry out in the solution.Low-oxidation-state cation is reduced into noble metal self with precious metal cation, is oxidized to higher oxidation state simultaneously.Preferred Reducing agent cation is a soluble cation under initial low-oxidation-state and final high oxidation state, and for example, Sn++ is oxidized to Sn++++, or Ti+++ is oxidized to Ti++++.

In second step, close to coming the reducing metal cation with activatory substrate, it reduces by precious metal catalyst.The cationic Reducing agent that is used to reduce is generally molecular species, for example, with regard to Cu++, is formaldehyde.Because Reducing agent is oxidized, so metal cation is called " oxidant cations " in this article.The substrate of consequent plating is characterised in that its coat of metal directly combines with substrate.

Based on said method, the person trained in a certain field who knows this area can also be according to its color identification oxidant state.When substrate being swum in the copper solution so that reduce as mentioned above, on every side of substrate, obtained different colors.The upside of substrate is glossiness bright copper (red/Huang) color, and this is the feature of elemental copper-Cu.The downside of fabric is a black, and this is the feature of CuO.Any substrate that is positioned at top substrate below also thereon side show degree of blackness.

In said method, this method is changed so that with the different cation types of copper but not elemental copper or copper oxide (CuO-black) plated fiber cellulose fiber or substrate.

The form of this electroless plating coating process is included on the surface for preparing on fabric or the substrate from such as copper sulfate or this class copper solution of copper nitrate cationic form of native copper also.Must be at first will treat that the fiber of coating or substrate immerse in the solution that contains at least a Reducing agent cation type with at least two kinds of positive oxidation state, immerse at least a cation type then in the solution than low state at least two kinds of positive oxidation state.Then fiber or substrate immersion are contained in the solution of at least a precious metal cation kind, produce activatory surface thus.

Make at least a oxidant cations kind in the fiber contact medium then, the surface of described medium contact activation.Add Reducing agent then and copper is reduced to himself on the fiber surface from solution.Owing to there is not following change, so use fiber that this scheme produces or substrate to show elemental copper coating on fiber, under the fiber that described fiber is arranged in fiber or substrate group's top and black is positioned at and be dispersed throughout fiber or substrate group.

As mentioned above, in order to obtain effectively to treat skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic surface, must obtain the cation type of copper.The active compound of copper must contain Cu (I) or Cu (II) kind or they both.On cellulose, must use Pd+ in order to ensure these kinds, so that for example make all fibres have equisaturation simultaneously by immersion and extruding.If big groups of fibers is immersed Pd++ solution, the first batch of fiber that contacts this solution so can absorb more Pd++ solution than the other parts of groups of fibers, and this can disturb cation copper deposition.In addition, washing the fibre between first process of Sn++ that must be in comprising water and second process of Pd++.Be retained in residual Sn++ solution between the fiber and can cause Pd++ directly to be reduced into solution between the fiber, and only can go back the Pd++ on the fibril at random, thereby influence the deposition of copper once more.Although these 2 seem may be very small, they have direct influence to coating.

In addition, the change of administration system that is used for the copper solution of described process is absolutely necessary.The ill effect of reduction process is to generate hydrogen on the fiber.This hydrogen occurs as the bubble on the fiber surface.The formation of hydrogen is Pd++ results of interaction on copper solution and the fiber surface.If not when forming at once by known method own, such as extruding from fiber surface except that dehydrogenation, the fiber of ingress of air will coated elemental copper so.These just are positioned at the copper oxide that the subsurface fiber of elemental copper can become black.Yet,, will all obtain required cation type in the groups of fibers so if when the bubble formation of hydrogen, remove it at once.Required color is a brown, and this color or cupric oxide with the copper metal is different.The extra indication of cation type is that fiber is non-conductive.

This method has produced Cu (I) and Cu (II) the kind ingredient as the copper oxide chemical compound.What the analysis of the residual cupric oxide powder that forms by this method was confirmed to form from the teeth outwards is the copper oxide chemical compound of 70%Cu (I) and 30%Cu (II).Verified these chemical compounds are very effective to treatment skin ulcer, scratch, burn and dermatosis.The activity of copper has utilized cation type can change between Cu (II) and Cu (I) with the redox reaction of water and when contacting water.Cu (I) is more effective to HIV than Cu (II), and Cu (II) is more stable than Cu (I).

In being equivalent to the U.S. Patent application US 10/339886 of PCT/IL03/00230, to have described and asked for protection and be used to make the virally inactivated device that comprises filtering material, described device has wherein mixed and has been selected from Cu ⁺And Cu ⁺⁺The ion copper of ion and combination thereof, also that the document is relevant instruction is incorporated herein by reference.

Described in this description and used the cellulose fibre coating that forms the copper solution of copper oxide on described fiber surface, wherein method therefor has produced Cu (I) and Cu (II) the kind ingredient as the copper oxide molecule.Then described fiber is mixed filter, find that it can effectively make the HIV-1 inactivation.Use the extra test of described filter disclose this combination also can effectively make west Nile fever virally inactivated and in and adenovirus and think that thus anti-virus hydrophilic polymeric material of the present invention also can effectively resist this viroid because they work with same mechanism.

Although do not understand the mechanism of hydrophilic polymer material of the present invention as yet fully, but according to the result who obtains, think when making this polymeric material contacting with fluid water-bearing media, described medium can be from the cation type of leaching copper in the described polymer, and described in PCT/IL03/00230, antiviral activity has utilized this cation type can change between Cu (II) and Cu (I) with the redox reaction of water and when contacting water.Cu (I) is more effective than Cu (II), and Cu (II) is more stable than Cu (I).Cu (II) compound oxidation is must be more than Cu (I) chemical compound more slow and can increase shelf life of product.

As mentioned above, discovery of the present invention is to have mixed and discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The material of the water-insoluble copper compound of ion or its combination unexpectedly effectively healing of wound and even the healing open wound, comprise following beat all discovery: this class material can make ulcer skin ulcer, the vascular lesion that causes because of diabetes and think up to now and be difficult to the similar wound healing of (even being not impossible) that heals, thereby can produce all new line products of the present invention.

Therefore, be the description of the scheme of some product and application thereof below:

Wound dressing: it can be the form of stocking yarn cloth or solid film.When being the gauze form, implement usually as the application of untreated sterile gauze, place material on the wound and with adhesive tape binding or fix in position.If the use thin film places thin film so on the wound area and with adhesive tape and binds so that it is held in place around its side.If fiber is hunted down or snarls,, so preferably use thin film as under the situation of burn wound.

Hospital and health care facilities clothing: it is by Cotton Gossypii/polyester or the textile form made based on the fabric of Cotton Gossypii, wherein the yarn of certain percentage (can change between 3%-10%) is the cellulose of processing, or wherein yarn fibers is the polymer of silk or staple fiber form.Goods can be knitting, such as plasticity wadding or socks, maybe can be knit goods, such as head covering or other clothes product, such as nightwear and underwear.Can use not contain extra cream or medicine, such as the goods of antibiotic or steroid ointment or medicine.These class clothing are particularly useful for chronic patients or other bedfast patients, so that prevention and healing extruding skin ulcer and decubital ulcer.

Binder: can be equipped with that viscosity is mounted backing layer so that it is held in place and can has the treatment pad of being made by the gauze of the fiber that uses polymer or cellulose to handle to them.In addition, in some cases, the thin film that can add processing is to replace gauze.

Medicated bra: the knit goods that it can be made by cellulose that can comprise the water-soluble cationic copper oxide particle or polymer fiber.

Nursing pad: it can be made by a series of absorbed layers, and described absorbed layer can contain the cellulosic loose fiber that wherein mixes polymerizable thing or processing.

The jointing material of filling: in some cases, the layer that has mixed water-insoluble cationic oxidation copper can not be ground floor.The layer of the processing of fabric can or descend one deck (thickness that depends on pad) and remain effective for second, as long as liquid reaches the layer of processing.

Masculinity and femininity underwear:, can meet the demands by the polyester of handling or the thread triangle lining cloth of cellulose yarn of mixed processing for the major part treatment.

Burn use sheath: they are preferably made by new respirable polymer, and described polymer can and disperse moisture by their wickings, used the introducing pressing method water-insoluble cationic oxidation copper particle manufacture these polymer.Thin film directly can be placed on the burn area and reduce concentrating on the wound surface, have the effect of required cation copper simultaneously.Although in conjunction with some preferred embodiment and the following example and describe the present invention with reference to the accompanying drawings, make and more completely to understand and to understand its aspect, and do not mean that and limit the invention to these specific embodiments.On the contrary, as what can comprise in the scope of the invention as the claim definition of awaiting the reply, should comprise all selections, modification and equivalent technical solutions.Therefore, the following example that comprises preferred embodiment is used to explain enforcement of the present invention, specific embodiments shown in should understanding only as an example and purpose be to explain discussion to the preferred embodiment of the invention, and provide their reason to be to think that it is the most useful and be used to understand description goods operating procedure and the principle of the invention and design aspect.

Description of drawings:

Accompanying drawing 1a and accompanying drawing 1b are at the photo for the treatment of the sufficient top of the diabetics of getting front and back described in hereinafter embodiment 3 according to the present invention.

Accompanying drawing 2a and accompanying drawing 2b for described in hereinafter embodiment 3 according to the present invention get before and after treating as described in the photo of vola portion of diabetics.

Accompanying drawing 3a and accompanying drawing 3b are at the lateral photo of foot for the treatment of the paralytic patient of getting front and back described in hereinafter embodiment 4 according to the present invention.

Accompanying drawing 4a is at the photo for the treatment of the vola portion of the different diabeticss of getting front and back described in hereinafter embodiment 5 according to the present invention with accompanying drawing 4b.

Accompanying drawing 5a and accompanying drawing 5b for as hereinafter embodiment 6 described in the photo of profile of adolescent patient of the trouble acne of getting before and after treating according to the present invention.

Accompanying drawing 6 can be breathed the electron micrograph of thin film for polypropylene, described thin film prepares through the following steps: the water-insoluble copper oxide with 1% is introduced masterbatch, after this cast film, thereby form the particulate thin film of microcosmic water-insoluble of ionic oxide formation copper, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface with powder type; And on its electron micrograph, be shown as white point; And

Accompanying drawing 7 is the electron micrograph of polyester fiber, described fiber prepares through the following steps: the water-insoluble copper oxide with 1% is introduced masterbatch, after this extruded fibers, thereby form the particulate fiber of microcosmic water-insoluble of ionic oxide formation copper with powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, and on its electron micrograph, be shown as white point.

Embodiment 1 prepares fabric by the cellulose fibre of handling

First.Select cellulose fibre to be used for required final application.In fiber, can use such as Tencel or acetas or viscose or this fibrid of raw cotton.Must be noted that fiber is necessary for based on cellulosic, initial binding fiber because coating uses OH from the teeth outwards.The fibre length of selecting is for the final function of using and be the common knowledge in the industry (promptly with regard to combing Cotton Gossypii etc., with long staple fiber and the fiber mixing with equal length).

Second.Make fiber by various chemical methodes as described herein:

1. the fiber of preparation in thin pad is to guarantee correct cation type deposition.

2. will fill up and immerse stannum dichloride and hydrochloric acid solution.This pad dipping short period is absorbed fully so that guarantee.

3. dummy block and remove nearly all liquid and wash with water then is so that guarantee to remove all solution of tin.

4. then pad is placed the extremely dilute solution of palladium chloride and hydrochloric acid.Although other slaine can be used for this method, find that palladium is the most effective.

5. after taking out from palladium chloride, washing and dummy block are to guarantee to remove all external liquid once more.At this moment, this spacer changes into cervine color.

6. use copper sulfate, Polyethylene Glycol and EDTA to prepare the copper-bath of chelating.By sodium hydroxide being added to the pH of control solution in this solution.In copper-bath, add Reducing agent.Although can use many Reducing agents, formaldehyde is elected to be preferred chemical compound.

7. pad is put into this solution and made its experience can reach the technology of absorption in 7 minutes.In the coating process, must push or pat this pad downwards.

8. wash this pad then with water so that remove excessive dust and make its drying.

9. when this method finishes, have for fiber coating and described fiber with the ionic species of copper and mixed dark-coloured dark-brown.

10. with fiber and other fiber (identical untreated or other fiber) fusion, so that end-product only contains the fiber of the copper oxide coating of aequum.In some cases, other fiber of 1% admixture/99% is required, and in other situation, other fiber of fiber/70% that preparation as many as 30% is handled or combination arbitrarily.Can carry out this process according to being the known several modes of the technical staff who knows yarn fabric yarn field.

11. make blended fiber through all normal textile processes, promptly with regard to the opening textile product: carded, sliver, weaving.

12. it is in case obtained yarn, just can be knitting or weave it according to required final application.

13. fabric can be used as or can be colored or print use subsequently, but can not bleached, because this can cause copper self to separate from cellulosic substrate.

14. yarn fabric is easy to be converted to required product subsequently.

Embodiment 2: prepare fabric or thin film by the polymeric material of handling:

A1. the selective polymer material is used for required final application.Such as this fibrids such as polyester, polypropylene, polyethylene, nylon 66 is operable fiber.Fiber can form thread form or short staple fiber form.

A2. use the host material identical to prepare masterbatch with the required yarn that adds cupric oxide powder.With regard to the final application of most of fabric, masterbatch can have the cupric oxide powder of the 20%-25% concentration that is included in wherein.This masterbatch can be joined in the polymer for the treatment of extrusion molding and dilution, so that only about 1% or 2% material is present in the finished product yarn.A certain amount of this copper appears on the polymeric fiber surface and can observe in electron microscope image.

A3. be filamentary fibers as fruit fiber, so can be knitting or be woven into textile with it.

A4. behave as fruit fiber and make short fiber, so can with its with other fiber just serving as that the mode of the above-mentioned coated fiber of mixing is mixed and deferred to identical production process then.

In case A5. yarn forms, just can be with it knitting or be woven into textile, this product be deferred to normal and acceptable system and is carried out the conversion of finished product.

B1. select to be used for the polymeric material of required final application.Such as this fibrids such as polyester, polypropylene, polyethylene, nylon 66, nylon 6 is operable fiber.Described polymeric material can form thin film or sheath.

B2. use with the required polymer phase that adds cupric oxide powder host material together and prepare masterbatch.With regard to the final application of major part, masterbatch can have the cupric oxide powder that accounts for 1-3% concentration therein.This masterbatch can be joined in the polymer for the treatment of extrusion molding.A certain amount of this copper appears on thin polymer film or the jacket surface and can observe in electron microscope image.

The preparation of embodiment 2 C-fibers

Amount to the polyamide pair-component cpd of 500 grams by two kinds of beading chemical substances preparations of heating in each comfortable 160 ℃ of independent bath down.

Then two kinds of independent compositions are mixed with each other and it was stirred 15 minutes, become evenly up to the color of this mixture.

Once more blended chemicals branch is gone into independent two jars.In a jar, add 25 gram CuO and Cu ₂The mixture of O powder obtains 1% mixture.In second jar, add the CuO and the Cu of 6.25 grams ₂The O mixture obtains 0.25% mixture.In two kinds of situations, keep 160 ℃ temperature.Stir these chemical compounds, even up to their color change.

Make two kinds of mixture by being with foraminous spinning head, described hole can produce the fiber that diameter is the 50-70 micron.Be lower than 20 microns granule owing to the cupric oxide powder that will discharge Cu++ grinds to form, block so observe the hole of spinning head.The fiber of extrusion molding is carried out air cooling and centers on the cone spinning.

The gained nylon fiber that has wherein mixed the copper oxide that discharges Cu++ can use in many application of the present invention, comprises binder, and the diabetes socks suffer from the glove of eczema or psoriatic patient or its hands or sufficient usefulness or socks etc.

Just as will be understood by the skilled person in the art, the conventional method and the difference between this method of producing any synthetic fibers have been to add the cupric oxide powder that discharges Cu++ in raw material, and, can exchange this base polymer of use such as polyester, nylon and polypropylene to many application of the present invention.

Embodiment 3: the healing of the ulcer skin ulcer that diabetes cause

With regard to accompanying drawing 1a and 2a, the sufficient face and the vola of 62 years old white race women with diabetes have been observed, wherein observe the ulcer skin ulcer that 1.5cm reaches bone deeply and in vola portion, and predetermined thus this patient implements to block art since 30 days 2 weeks of JIUYUE in 2004 in this zone of foot, gets the photo of accompanying drawing 1a and 2a this moment.

Assistance carry out product of the present invention clinical trial this patient the doctor with as according to the gauze parcel patient's of containing 3% cellulose fibre of US application 10/339886 that is equivalent to PCT/ILO3/00230 and method as indicated above preparation foot, wherein with being selected from Cu ⁺And Cu ⁺⁺Ionic ion copper applies the cellulose fibre of described processing, and that promptly form on described fiber surface is Cu ⁺And Cu ⁺⁺Insoluble copper oxide chemical compound.

As can be observed in accompanying drawing 1b and 2b, described accompanying drawing is the photo of the same patient's that 1 week got after 7 days October in 2004 identical foot, the result who obtains unexpectedly shows the vascular lesion elimination, skin corium regeneration, and the most beat all be that diabetic ulcer in the portion of vola is clean and closed.

As the result of this treatment, foot blocks no longer necessity of art.

Embodiment 4: the healing of paraplegia infringement property skin ulcer

With regard to accompanying drawing 3a, in the infringement of taking from the sufficient side of observing 36 years old white race male paraplegia person on 23 days the photo of JIUYUE in 2004, this patient has this infringement and reaches 6 months, and reason is to contact the skin ulcer that the limbs fixation clamp of its wheelchair forms.On the same day, can breathe the described zone of film wrapped with polypropylene, described polypropylene can be breathed thin film and prepare through the following steps: 1% water-insoluble copper oxide is introduced masterbatch, after this cast film, thereby form the particulate thin film of microcosmic water-insoluble of ionic oxide formation copper with powder type, wherein directly embedding the described granule that partly exposes and give prominence to from its surface, as observed from associated accompanying drawing 6, these particle release Cu ⁺⁺

With regard to accompanying drawing 3b, this accompanying drawing is the photo of getting in 2 weeks after 7 days October in 2004, and unresponsive infringement begins healing and clearly be shown as fibrocyte regeneration on photo to any conventional therapy in 6 months time limits can to observe this.

Embodiment 5: the diabetic skin granuloma is improved

With regard to accompanying drawing 4a, on photo, observe 76 years old white race male diabetes patient's vola, this photo was taken from JIUYUE in 2004 28, and wherein observed the severe granulation of skin area.

In JIUYUE 28 days, the designated APAIR OF SOCKS that begins to dress special preparation of this patient, it is made by polyester and wherein exists the use of introducing to discharge Cu ⁺⁺The polyester fiber that forms of cupric oxide powder, these fibers are as shown in accompanying drawing 7, and these fibers have the microcosmic water-insoluble granule of the ionic oxide formation copper of powder type, in the described fiber directly embedding the described granule that partly exposes and give prominence to from its surface, these particle release Cu ⁺⁺And form the fabric that contains 1% copper oxide at its downside.

With regard to accompanying drawing 4b, this accompanying drawing is the photo of getting on October 6th, 2004, can observe the skin area appearance regeneration that previous granulation forms.

Thinking thus provides the socks according to the present invention's preparation can be used for prevent diabetes granuloma, ulcer and infringement formation to diabetics, and can be used for its treatment.

Embodiment 6: the treatment of adolescent acne

With regard to accompanying drawing 5a, on photo, observe the 16 years old white race male's who suffers from acne side view, this photo is taken from October 10th, 2004.

This patient is designated to place gauze pad the next-door neighbour every night it is encroached on location, described gauze pad make by polyester and wherein exist introduce by discharging Cu ⁺⁺The polyester fiber that constitutes of cupric oxide powder, these fibers are as shown in accompanying drawing 7, and these fibers have the microcosmic water-insoluble granule of the ionic oxide formation copper of powder type, in the described fiber directly embedding the described granule that partly exposes and give prominence to from its surface, these particle release Cu ⁺⁺Formation contains the gauze pad of 1% copper oxide.

With regard to accompanying drawing 5b, observed this patient's who takes from October 13 photo, only using gauze pad of the present invention after 3 nights, visible huge improvement and acne size reduce, and this minimizing is generally speaking only in the back appearance of several weeks.

Embodiment 7: play the burn without leaving scars healing of vesicle

57 years old women of white race suffers from 2 about 6 inches * 2 inches burns that play vesicle of spending on its thigh, reason is that one cup of boiling hot tea is poured on its knee suddenly.

Cover burn area with gauze pad of the present invention, this gauze pad make by Cotton Gossypii and wherein exist introduce by discharging Cu ⁺⁺The cellulose fibre that constitutes of cupric oxide powder, these fibrages become gauze and form the finished product that 97% Cotton Gossypii and 3% discharges the fiber of cation copper.Regularly use the pad of the same material of new system to replace gauze pad, continued for 3 weeks, after this, remove pad to have exposed vesicle and the burned skin slough that come off fully, left over the fresh layer of the epidermal tissue of no cicatrix, should the zone after 1 week basically with the peripheral region indifference.

Embodiment 8: clinical trial

The Board Certified Neurologist Dr.MichaelS.Smith that request has master's degree uses experimental statistics analysis use to mix release Cu ⁺And Cu ⁺⁺The socks of one fritter textile of ionic water-insoluble copper compound are to various brothers' diseases, the i.e. effectiveness of erythema, pruritus and burn, ichthyosis, herpes, be full of cracks, drain, abnormal smells from the patient and edema.

Studied one group of patient; And result and brothers doctor are compared the experience of patient with the socks treatment of the present invention of not using of similar disease.

The result:

Think that following result all has statistical significance, promptly have reliable medical evidence to show to use socks treatment of the present invention during follow-up investigation effectively because all results' confidence interval does not comprise 0 and all results' p-value＜0.001.

Demographic:

In all 56 patients, 17 is the women, and 39 is the male.The mean age of this group is 58 years old, and standard deviation is 16 years old (scope 21-85 year).21 (21) is diabetes, and 21 ages surpass 65 years old, and subsequently 24 are carried out following up a case by regular visits to more than 1 time.

Variable:

7 kinds of measured values have been studied: erythema, burn and pruritus, edema, ichthyosis, herpes, be full of cracks, drain and abnormal smells from the patient.Only ichthyosis is present among all 56 patients, wherein has erythema (referring to table) in 51.Edema (6), abnormal smells from the patient (5) and drain (3) are least common variable." long term follow-up meant used the socks post-evaluation once more than.The used order grade that has three kinds of levels: exist, improve and disappear.Think to move forward and (, think oppositely mobile (from " improvement " to " the negative sign of existence ") from " existence " to " improvement " or in the past two kinds situations to " ") positive sign that disappears along this grade.Disappear if recognize when a patient goes to a doctor after dressing socks first, should can be " identical " long term follow-up by scoring at the most by individuality so.Therefore, can think that " identical " is equal to " keeping improving ".Average length of time in the long-term stage is defined as the time between the date of following up a case by regular visits to for the first time when relevant this patient is estimated for the last time.Only there is the patient of particular problem in statistics when this research begins subsequently.Exhausted situation about not having is not exist the patient of particular problem a kind of situation to occur.In the situation of edema, abnormal smells from the patient and drain, sample size is too small and can't draw any conclusion, but, still the result is tabulated.

Embodiment 8A: erythema (51 patients)

A1. in the average 9 days time limit, all 51 patients improve; 22 (42%) disappear fully (4-28 days).95% confidence interval of disappearing is (0.29,0.58).Although this result means the percentage ratio (parameter) that we do not understand whole colony and disappear fully, we are very confident to think that it belongs in the interval of 29%-58%.Do not having general no patient's improvement under other treatment situation if we understand in advance in this time range, the result of Huo Deing has meaning very much so; Promptly be not occurrent.

A2. (22 patients) studies for a long period of time:

19 (86%) has been kept its improvement or has been disappeared, 95%Cl (0.65,097).3 patients (14%) do not keep improvement or return to " existence ", 95%Cl (0.03,0.34).Follow up a case by regular visits to average during be 36 days.Diabetics and surpass 65 years old patient improvement is all arranged in early days or for a long time.

Embodiment 8B: ichthyosis (56 patients):

There are 55 (55) to improve (98%) in the B1.56 position, 5 disappear (9%), and 1 rest on identical.95% confidence interval of identical improvement is (0.90,1.00); Disappear and be (0.03,0.20).For effect, the p-value is all very meaningful.

B2. (24 patients) studies for a long period of time:

21 (88%) has kept improving or disappearing, and 3 are recovered when average 34 days following up a case by regular visits to.95% confidence interval is (0.68,0.97), wherein p-value＜0.001.In addition, diabetics and middle-older patient all have improvement.

Attention: follow up a case by regular visits to figure and have identical yardstick with the above-mentioned figure that helps comparison.

Embodiment 8C: be full of cracks (37 patients):

C1. all 37 patients improve; 15 (40%) disappear fully, and wherein average follow-up period is 10 days, 95%Cl (0.25,0.58).This is very significant.

C2. (17 patients) studies for a long period of time:

In average 39 days follow-up period, all 17 patients improve; 6 (35%) disappear fully, 95%Cl (0.14,0.62).Diabetics and middle-older patient all have improvement.

Embodiment 8D: burn or pruritus (23 patients):

D1. in average 8 days follow-up period, there are 19 to improve (83%) in 23,4 rest on identical or reverse.95% confidence interval is (0.61,0.95), and wherein the p-value is 0.003, and is also very meaningful.

D2. (8 patients) studies for a long period of time:

All 8 patients all do not change in 46 days average follow-up period limits, this means that its initial improvement is maintained.Can't study diabetes and middle-older patient to such an extent as to quantity is too small.

Embodiment 8E: herpes (23 patients)

All 23 patients of E1 improve; 13 (56%) disappear fully, 95%Cl (0.34,0.76).

E2. (10 patients) studies for a long period of time:

All 10 patients have kept its improvement or disappear (6) in 45 days average follow-up period limits.This ratio and the ratio in diabetics and over-65s patient are similar.

Embodiment 8F: edema (6), drain (3) and abnormal smells from the patient (5):

3 patients with edema improve; 1 disappears.All 3 patients with drain improve; 2 disappear.Have among 5 patients of abnormal smells from the patient 3 improvement are arranged, wherein 2 disappear.Data have been summarized in the relevant table.In addition, word " deterioration " mean patient from " disappear " or " improvement " be back to " existence ".

Discuss:

The purpose of this research is to observe the socks whether patient that suffers from various brothers' diseases only have a fiber bale of the present invention by wearing and just can improves.A problem in the above-mentioned disease of treatment is to obtain and use the compliance of this treatment (special-purpose socks).Relevant issues are at suitable administering therapeutic (special-purpose socks) on the plantar surfaces of toe and between toe.

1. with regard to the purpose of these embodiment, infer as follows to the analysis of the data that provide:

A. the patient is the rational representational sample of the patient colony of these diseases of existence.Still there is not the information of receiving with this deduction contradiction.There are male, women, old people, youngster, diabetics and ND.

B. the patient is independently of one another; Promptly being selected from one by one, body influences selecting another individual nothing.

C. the definition that improves and disappear is constant for every patient.

D. known sample size and suitably analyzing.

E. the result can be defined as and be divided into two.

The existence of these deductions can use binomial probability to distribute.

2. the matched group that does not have report; Yet the information of receiving thinks that brothers doctor thinks that any patient is only disappeared or improved by the socks of dressing customization is impossible in this search time scope.Owing to obtained this category information,, promptly existed medical evidence to think and use fiber bale treatment of the present invention effective in this follows up a case by regular visits to the time limit so think that all The above results have statistical significance.

Importantly understand the vocabulary that is used to describe this research:

-colony: the group that relevant hope is learned.In this case, colony is all patients with above-mentioned pedopathy.

-sample: colony's subgroup.

-random sample: the subgroup of selection, wherein each member in the colony has the selection probability of definite non-zero.

-parameter, the DATA REASONING value of colony.

-statistics: the DATA REASONING value of sample.

-p-value: the concrete sample statistics that we can obtain is learned probability (or an above extremum), and condition is that invalid inferring (unaltered inferring) is correct.Study in the whole process at this, the p-value less than 0.001 mean obtain separately these results at random probability in 1000 less than 1.Generally speaking, think have 1 to be " cut-off point in 20.Minitab software can't be calculated to the p-value 4 decimal digits, obtain thus herein numerous in addition less.

The confidence interval contains the seemingly reasonable value of the certain limit that is useful on parameter.We are called the confidence interval with it, although because unknown, parameter exists really, and the interval is contained or do not contain this parameter.It is not a probability problem.With regard to this research, if inferring in the time bar that uses conventional therapy research, we do not have the patient to improve, as long as the interval does not contain 0, the result just has meaning so, is 0 because do not have like reasonable value in the parameter.Improve if infer some other ratio, think that so any interval that does not contain occurrence has meaning.In this research, owing to obtained above-mentioned information, so All Ranges has all reached statistical significance.

Cycle of inference: we take a sample from colony, obtain result's (statistics) and use this value to infer about some situation as the parameter of colony's ingredient.

Population sample

Parametric statistics

Importantly recognize all members that can identify hardly in the colony, its DATA REASONING value, parameter are still unknown thus.With regard to this research,, be used to represent the similar colony ratio that also can improve so ratio is improved the sample results of (or disappearing) because we can not learn all members in the colony.If sample is selected suitably, estimated value has value so.Certainly, we must recognize that other samples can produce other result, thus, as mentioned above, have the seemingly reasonable value that sample has of can thinking of certain limit, and our sample are one of those possible values.

Conclusion:

Owing to compared the medical history contrast, used with having mixed as discharging Cu according to the present invention ⁺And Cu ⁺⁺The patient of the socks of the fritter textile of ionic water-insoluble copper compound exists in following situation and significantly improves or disappear:

The erythema herpes

The be full of cracks of burn/pruritus

The ichthyosis drain

In addition, (in 51 19) be diabetes or the patient above 65 years old (10 diabetes and above 65 years old) because nearly 40% in the group, so this research for all above-mentioned situations of the people that suffers from diabetes improve or disappear aspect have statistical significance, comprise the middle and elderly diabetic patient.

As known, erythema is characterised in that the skin rubefaction that causes because of blood capillary swelling and hyperemia and is generally inflammation or the sign of infection, and is the healing target thus.

Pruritus and burn are the healing target.

For curing target, the product that it can the application of the invention improves ichthyosis when its psoriasis with microorganism property is relevant.

Herpes is with the approaching blood capillary rash of skin surface and thus also for curing target.

Drain is to remove fluid or suppurative material with the product of the present invention that promotes wound healing from wound or body cavity.

Edema for observable swelling on some position in vivo and modal be to occur in foot and shank, wherein also relate to peripheral edema.Swelling is the interior spatial result of tissue that excess fluid is accumulated in subcutaneous blood vessel outside, and uses method of the present invention and product can promote its healing.

Be full of cracks is common cracking on the skin, and wherein it is connected with mucosa, produces crack sample skin ulcer or ulcer, and this also is can be according to the healing target of the present invention's processing.

The apparent the present invention of those skilled in the art is not limited to the particular content of above-mentioned exemplary embodiments, and can under the situation that does not break away from spirit of the present invention, implement the present invention with other concrete form, and need thus to think that embodiment of the present invention and embodiment are exemplary in all respects and do not play the qualification effect, benchmark is with reference to awaiting the reply claim, but not foregoing description, and the institute that belongs to claim equivalents and scope changes and includes therein thus.

Claims

1. treat and healing skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic method, comprise the body surface that shows above-mentioned situation is used the material that mixed the water-insoluble copper compound so that it is treated and heals, described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

2. the process of claim 1 wherein that described skin ulcer is the ulcer skin ulcer.

3. the process of claim 1 wherein that described skin ulcer is a decubital ulcer.

4. the process of claim 1 wherein that described skin ulcer is the ulcer skin ulcer that is caused by diabetes.

5. the process of claim 1 wherein that described infringement is a vascular lesion.

6. the process of claim 1 wherein that described infringement is a mucosal injury.

7. the process of claim 1 wherein that described material is the fabric with fiber, mixed release Cu when contacting with fluid in the described fiber ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

8. the method for claim 1, wherein said material is the particulate thin polymer film of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

9. the method for claim 1, wherein said material is the particulate polymer fiber of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

10. the method for claim 1, wherein said material is the particulate polymer filament of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

11. the method for claim 1, wherein said material is the particulate polymer jacket of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

12. the method that is used for the treatment of the outburst of male genital organ herpes sore of claim 1 comprises the underwear with fiber is provided, and has mixed in the described fiber to discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

13. the method that is used for the treatment of acne of claim 1 comprises but it is used the fabric with fiber, has mixed in the described fiber to discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

14. the method that is used for the treatment of hello newborn women's nipple skin ulcer of claim 1 comprises medicated bra or the nursing pad with fiber is provided, and has mixed in the described fiber to discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

15. the method that is used for the treatment of burn of claim 1 comprises wound healing thin film or silk that the wound healing fabric that is applied to described burn surfaces or extrusion molding are provided, has wherein mixed to discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

16. when contacting with fluid, discharge Cu ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination preparation contact have skin ulcer, scratch, ulcer, infringement, skin openings, burn and dermopathic body surface so as it to be treated and the wound healing material that heals in application.

17. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic binder in preparation.

18. the described application of claim 17, wherein said binder is made of the gauze material that has wherein mixed described copper compound.

Be used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic binder 19. have the particulate thin polymer film of microcosmic water-insoluble of the ionic oxide formation copper of powder type in preparation, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

20. the described application of claim 17, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

21. the described application of claim 17 has applied described copper compound on the wherein said fiber.

22. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the application of patient's clothing that hospital and health care facilities form with the prevention decubital ulcer in preparation.

23. the described application of claim 22, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

24. the described application of claim 22 has applied described copper compound on the wherein said fiber.

Be used for the treatment of application in the protective jacket of the skin ulcer that forms on the body limbs 25. have the particulate thin polymer film of microcosmic water-insoluble of the ionic oxide formation copper of powder type in preparation, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

26. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in the protective jacket of the skin ulcer that forms on the body limbs in preparation.

27. the described application of claim 26, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

28. the described application of claim 26 has applied described copper compound on the wherein said fiber.

29. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic dressing in preparation.

30. the described application of claim 18, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

31. the described application of claim 18 has applied described copper compound on the wherein said fiber.

Be used for the treatment of application in skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and the dermopathic dressing 32. have the particulate thin polymer film of microcosmic water-insoluble of the ionic oxide formation copper of powder type in preparation, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described thin polymer film, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

33. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The male that the fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of male genital organ herpes sore outburst in preparation is with the application in the underwear.

34. the described application of claim 33, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

35. the described application of claim 33 has applied described copper compound on the wherein said fiber.

36. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for feeding the medicated bra of wet nurse parent treatment nipple skin ulcer and the application of nursing pad in preparation.

37. the described application of claim 33, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

38. the described application of claim 33 has applied described copper compound on the wherein said fiber.

39. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the treatment of application in the dressing of acne in preparation.

40. the described application of claim 39, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

41. the described application of claim 39 has applied described copper compound on the wherein said fiber.

42. the elastic bandage pad of filling is wherein mixed described fiber in the described application of claim 39.

43. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is subjected to the body surface of psoriasis infringement so that the application in the fabric that it is treated in the preparation contact.

44. the described application of claim 43, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

45. the described application of claim 43 has applied described copper compound on the wherein said fiber.

46. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is subjected to the body surface of eczema infringement so that the application in the fabric that it is treated in the preparation contact.

47. the described application of claim 46, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

48. the described application of claim 46 has applied described copper compound on the wherein said fiber.

49. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination has skin ulcer, scratch, burn and dermopathic body surface so that the application in treatment and its fabric of healing in preparation contact.

50. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The application of the fiber of the water-insoluble copper compound of ion or its combination in the preparation suture material.

51. have the application of the particulate polymer filament of microcosmic water-insoluble in the preparation suture material of the ionic oxide formation copper of powder type, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described polymer filament, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

52. treatment skin ulcer, cold sore, skin openings, ulcer, infringement, scratch, burn and dermopathic method, comprise the polymeric material that constitutes by component of polymer using on it, described component of polymer is selected from polyamide, polyester, acrylic acid and poly-olefin(e), described material is the form of fiber, yarn, sheath, silk or sheet, and microcosmic water-insoluble granule with ionic oxide formation copper of powder type, directly be embedded with the described granule that part exposes and give prominence to from its surface in the described polymeric material, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

53. the method for prevent diabetes granuloma, infringement and ulcer comprises that the material that will mix the water-insoluble copper compound is applied to the protected area, described chemical compound discharges Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

54. the method for prevent diabetes granuloma, infringement and ulcer; comprise and to use the protected area by the polymeric material that component of polymer constitutes; described component of polymer is selected from polyamide, polyester, acrylic acid and poly-olefin(e); described material is the form of fiber, yarn, sheath, silk or sheet; and microcosmic water-insoluble granule with ionic oxide formation copper of powder type; directly be embedded with the described granule that part exposes and give prominence to from its surface in the described material, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination.

55. the method for claim 53, wherein said material are the fabric with fiber, have mixed in the described fiber to discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination.

56. the method for claim 1, wherein said material is the particulate thin polymer film of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination, wherein said thin film has the ability by the osmosis dispersing liquid.

57. the method for claim 1, wherein said material is the particulate thin polymer film of microcosmic water-insoluble with ionic oxide formation copper of powder type, wherein directly be embedded with the described granule that part exposes and give prominence to from its surface, these granules discharge Cu when contacting with fluid ⁺Ion, Cu ⁺⁺Ion or its combination spreads all over the micropore that runs through so that excessive liquid is discharged on the wherein said thin film.

58. when contacting with fluid, discharge Cu ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination is used for the application of the wound healing fabric of army's uniform or underwear or coat goods in preparation, and the described fabric that comprises fiber can obtain antibacterial effect and the healing effect to described wound when entering the wound of military staff in spite of wound of dressing it.

59. mixed and when contacting with fluid, discharged Cu ⁺Ion, Cu ⁺⁺The fiber of the water-insoluble copper compound of ion or its combination is used for the application of army's uniform or underwear or coat goods in preparation, and described fiber can obtain antibacterial effect and healing effect to described wound when entering the wound of military staff in spite of wound of dressing it.

60. the application of claim 59, wherein said fiber is for wherein having mixed described chemical compound and described chemical compound from the outstanding polymer fiber in its surface.

61. the described application of claim 59 has applied described copper compound on the wherein said fiber.

62. when contacting with fluid, discharge Cu ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination preparation contact have skin ulcer, scratch, ulcer, infringement, skin openings, burn and dermopathic body surface so as it to be treated and wound healing thin film, silk or the sheath of the wound healing fabric that heals or extrusion molding in application.

63. when contacting with fluid, discharge Cu ⁺Ion, Cu ⁺⁺The water-insoluble copper compound of ion or its combination is selected from application in the medicated clothing of patient's clothing of nightwear, women's nightwear and underwear that hospital and health care facilities use in preparation, discharges Cu when described medicated clothing has the contacting with fluid of being included in ⁺Ion, Cu ⁺⁺The cloth sheet of the embedding of the water-insoluble copper compound of ion or its combination, this cloth sheet be embedded in medicated clothing at least with the contiguous zone of patient's seat area so that prevention and healing decubital ulcer and extruding skin ulcer.