CN101072600A - System and method for delivering a therapeutic agent for bone disease - Google Patents
System and method for delivering a therapeutic agent for bone disease Download PDFInfo
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- CN101072600A CN101072600A CN 200580041894 CN200580041894A CN101072600A CN 101072600 A CN101072600 A CN 101072600A CN 200580041894 CN200580041894 CN 200580041894 CN 200580041894 A CN200580041894 A CN 200580041894A CN 101072600 A CN101072600 A CN 101072600A
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Abstract
Various systems, and methods are provided for transporting a therapeutic agent to the interior of a skeletal support structure. In one implementation, a first elongated member, a second elongated member and an expandable structure provide for non-axial access to the interior of a skeletal support structure. The second elongated member is configured to transport a radiation source through a lumen in the first elongated member to the interior of the skeletal support structure.
Description
Technical field
The present invention relates to the treatment of osteopathia.Particularly, thus the present invention relates to be used to enter the system and method that bone is placed therapeutic agent.
Background technology
When the spongy bone pathological changes, for example, the pathological changes owing to osteoporosis, avascular necrosis or cancer, it can't provide suitable support for cortical bone on every side again.Therefore bone becomes and is more prone to compression fracture or subsides.
Radiation therapy and chemotherapy are generally used for treating cancer, for example backbone metastatic carcinoma.Radiation therapy can be used in any way, comprises outside radiation exposure treatment, stereotaxic radiosurgery treatment, and permanent or temporary matter brachytherapy.
Summary of the invention
The method and apparatus that describes below can directly be placed on therapeutic agent in the internal cavities of skeletal support structure (for example vertebral body), reduces to minimum to the exposure of the harmful side effect of ray and this Therapeutic Method surrounding tissue simultaneously.In one embodiment, first slender member has tube chamber, and described tube chamber is configured to provide the non axial passage that enters skeletal support structure inside.Second slender member is configured to therapeutic agent is delivered to skeletal support structure inside via described tube chamber.
To set forth the details of one or more embodiments of the present invention in the the accompanying drawings and the following description.Other features of the present invention, purpose and advantage are conspicuous from description, accompanying drawing and claims.
Description of drawings
Fig. 1 illustrates the device that comprises first slender member and have second slender member of expandable structures.
Fig. 2 A illustrates the not expandable structures of deployed configuration that is that is connected to second slender member.
Fig. 2 B illustrates the expandable structures that is deployed configuration that is connected to second slender member.
Fig. 2 C illustrates the cross-sectional end view of the expandable structures of Fig. 2 B.
Fig. 2 D illustrates the cross-sectional end view of second slender member of Fig. 2 A.
Fig. 3 illustrates the device that comprises first slender member and have second slender member of expandable structures, and this device is arranged in the vertebral body.
Fig. 4 A illustrates the not expandable structures of deployed configuration that is that comprises main tube cavity and a plurality of sublumen.
Fig. 4 B illustrates the expandable structures of Fig. 4 A that is deployed configuration.
Fig. 4 C illustrates the cross-sectional end view of the expandable structures of Fig. 4 B that is deployed configuration.
Fig. 4 D illustrates the cross-sectional end view of second slender member of Fig. 4 A.
In institute's drawings attached, identical Reference numeral is represented components identical.
The specific embodiment
Fig. 1 illustrates the device 100 that is used for providing to skeletal support structure inside radiation source.Device 100 comprises first slender member 101 with tube chamber 104, and wherein first slender member 101 is configured to provide the non axial passage that enters skeletal support structure inside.In a kind of implementation, first slender member 101 can be configured to, for example, intubate, conduit, pin, trocar or other suitable accesss to plant.Device 100 comprises second slender member 102, and it is configured to therapeutic agent is delivered to skeletal support structure inside via the tube chamber 104 of first slender member 101.At last, device 100 comprises expandable structures 103, and it is configured to insert in the skeletal support structure, and wherein expandable structures 103 is configured to generation/expansion space in skeletal support structure.
The therapeutic agent that is transported to skeletal support structure inside can include but not limited to, for example, and chemotherapeutant, radiation source or its combination.
The skeletal support structure that operative installations 100 enters can include but not limited to, for example, and bone, cartilage and sclerotin derivant thereof, film skeletonization and replacement bone.As shown in Figure 3, in a kind of implementation, first slender member 101 helps entering the skeletal support structure of being made up of vertebral body 301.Especially, as shown in Figure 3, enter the internal cavities 304 that contains spongy bone 305 usually via the pedicle of vertebral arch 303 of vertebral body 301 by first slender member 101.For example use that pedicle of vertebral arch is outer, the outside, back, side direction or the operation of the place ahead route, by the sidewall of vertebral body 301, perhaps can also enter vertebral body 301 inside by vertebral body 301 soleplates.
Shown in Fig. 1,2A-2C and 3, in a kind of implementation, second slender member 102 has far-end, and this far-end comprises the expandable structures 103 that is configured to produce space 302 (for example, referring to the space among Fig. 3 302) in skeletal support structure.Term used herein " expandable type " is meant the performance that comprises elasticity, non-resilient and part elasticity/non-resilient extensibility of described structure.Expandable structures can be made by deformable plastics or metal material.Term used herein " generation space " intention comprises the existing space that enlarges in the skeletal support structure, comprises that also expansion skeletal support structure inside is to produce the space.Can before being entered or when being entered, comprise the space by device 100 skeletal support structure that enter.Also can use above-mentioned expandable structures 103 to enlarge described space that existed in the past or that when entering, form.
Shown in Fig. 2 A-D, expandable structures 103 is connected with second slender member 102, and expandable structures 103 is configured to skeletal support structure delivered inside radiation dose.In the implementation that illustrates, expandable structures 103 comprises first expandable structures 200 and second expandable structures 201.First and second expandable structures 200 and 201 are configured to limit main tube cavity 202 and sublumen 203 (referring to Fig. 2 A-C).The suitable main tube cavity 202 and the example of sublumen and 203 include but not limited to manage, internal open space or cavity in sleeve pipe, bag, cover, capsule, bag or the conduit.In a kind of implementation, main tube cavity 202 and sublumen 203 stretch in second slender member 102 and extend the distance of the length of second slender member 102 basically.Can hold radiation source between first expandable structures 200 in the sublumen 203 and second expandable structures 201.Can control the expansion of expandable structures 103 by in main tube cavity 202, adding material (for example fluid).
In one embodiment, shown in Fig. 2 B and 2C, first expandable structures 200 is configured to realize relevant deployable state with second expandable structures 201.Term used herein " relevant deployable state " intention describes that first expandable structures 200 and second expandable structures 201 depend on the elasticity of first expandable structures 200 and second expandable structures 201 or other performances and synchronously or non-synchronously with identical or different speed or realize the expansion of fixed relationship or variable relation in any suitable manner.For example, first expandable structures 200 can be expanded to first size, and second expandable structures 201 can be expanded to substantially the same first size simultaneously.Perhaps, first expandable structures 200 can be expanded to first size, and second expandable structures 201 can be expanded to second size simultaneously.After the expansion, first expandable structures 200 and second expandable structures 201 are configured to not unfolded.This not deployment configuration for example can be convenient to from skeletal support structure, to take out part or all of device 100.
In a kind of implementation, it is remote visualization (for example using fluoroscopy, X-ray, MRI, CT scan or area of computer aided imaging) that second slender member 102 is formed at far-end, and described far-end is positioned at skeletal support structure inside.This structure can comprise the suitable labelling apparatus (not shown) that is used for remote visualization, and it is disposed in basically the position near the far-end of second slender member 102.For example, this structure indicia band (markerband) that can use one or more rays to see through realizes.In another example, expandable structures 103 can comprise one or more radio-opaque substances (radiopacifier).The example of radio-opaque substance includes but not limited to iodine (for example can available from the CONRAY of Mallinckrodt), gadolinium, tungsten, tantalum, barium, strontium.Think and radio-opaque substance can be arranged in the main tube cavity 202 and/or sublumen 203 of expandable type structure 103.Perhaps, can use radio-opaque substance co-manufactured first expandable structures 200 and/or second expandable structures 201, perhaps radio-opaque substance can be coated on the inside or the outside of expandable structures 103.
In another kind of implementation, first slender member 101 further comprises the device (not shown) that is used to thrust skeletal support structure.Term used herein " is used to thrust the device of skeletal support structure " and includes but not limited to probe, drill bit, trocar, needle assembly, conduit and other any available apparatus that is used to thrust skeletal support structure.The device that is used to thrust skeletal support structure can be connected with the far-end of first slender member 101, perhaps is configured to be used in combination with slender member 101.The device that is used to thrust skeletal support structure can also be connected with second slender member 102.
In a kind of implementation, radiation source can be placed on precalculated position (for example, with respect to skeletal support structure).When progressively locating, the precalculated position can be a series of basically near skeletal support structure or be positioned at the stop place (below will discuss to it) of skeletal support structure inside.The location of radiation source can be controlled by the structure of first slender member 101 and second slender member 102.First slender member 101 includes but not limited to the relevant structure of second slender member 102, for example, passes on the labelling or the mark (not shown) of the position relation between first slender member 101 and second slender member 102.Can determine the measured value of skeletal support structure and the distance that calculating is placed on desired location by using CT scan, thereby help the location radiation source.Can also control the location of radiation source in skeletal support structure based on the expansion of expandable structures 103.For example, the relative amount of expansion of expandable structures can provide near the location (for example, in the internal cavities 304 vertebral body 301) of the radiation source that is configured in the expandable structures 103 or a plurality of pre-positions it inner in skeletal support structure.
In a kind of implementation, radiation source is configured to provide the radiation dose that is positioned substantially at skeletal support structure inside.Especially, thus can regulate the form of radiation source and the structure and the configuration of the material and second slender member 102 provides required local dose.This dosage can calculate.For example, can using dosage assay method (dosimetry plan) calculate radiation source should the specific portion position (stop place) in skeletal support structure in experience how long (time of staying).
In specific implementation, use afterloader (afterloader) (not shown) that radiation source is placed in the space 302.Afterloader can be connected to the tube chamber of second slender member 102 of device 100, is used for introducing radiation source at tube chamber.
In one embodiment, radiation source is a radionuclide.Radionuclide can be the form of liquid, seed, pin, ball, granule or microsphere, or is the form of other any suitable radionuclides that are used for radiation therapy.Radionuclide can comprise Au-198, Co-60, Cs-137, I-125, I-135, lr-192, P-32, Pd-103, Ra-226, Rh-106, Ru-106, Sr-90, Y-90 or other any isotopes that is applicable to radiation therapy, and can be liquid, solid maybe can by electronics brachytherapy instrument (can be available from Xoft, Inc.) original position produces.
In a kind of implementation, device 100 further comprises the radiation shield that is configured to the radioactive source shielding (not shown).The ray that described protective shield can be configured to hold from radiation source discharges ray until needs, for example provides dosage to local bone.In one embodiment, described protective shield can be configured to around second slender member 102 and/or connected expandable structures 103 (not shown).In another embodiment, protective shield can comprise wire netting, and after expandable structures 103 was launched, this wire netting was inserted into skeletal support structure inside.In another embodiment, described protective shield can be incorporated in first expandable structures 200 and/or second expandable structures 201.
Referring to Fig. 1 and 3, use the method for said apparatus 100 to comprise: first slender member 101 that will have tube chamber 104 non-axially is inserted into skeletal support structure inside, and described tube chamber 104 limits the admission passage that enters skeletal support structure inside; Second slender member 102 is inserted in the tube chamber 104, and described second slender member 102 is configured to skeletal support structure delivered inside radiation source; And radiation source is transported to skeletal support structure inside via tube chamber 104.
In a kind of implementation, the method for operative installations 100 further comprises at least a portion of launching second slender member 102, thereby in the inner space 302 that produces of skeletal support structure.Can choose wantonly and before or after carrying radiation source, make 102 expansion of second slender member, thereby produce space 302 via tube chamber.
In another kind of implementation, the method for operative installations 100 further is included in the space 302 and deposits backing material.Backing material can be bone cement (for example, polymethyl methacrylate (PMMA), pottery), people bone graft (autograft and allotransplant), the synthetic bone substitute that obtains, for example calcium sulfate, calcium phosphate and hydroxyapatite.In addition, in another implementation, backing material can comprise chemotherapeutant.
In a kind of implementation, carry the method step of radiation source further to be included in one or more stop places placement radiation sources.And this method can comprise determines that a plurality of stop places are to provide the radiation dose that is positioned substantially at skeletal support structure inside.Determine that the stop place software that includes but not limited to use a computer determines the stop place.
In another implementation, the method step that first slender member 101 is inserted comprises first slender member 101 is inserted into (see figure 3) in the internal cavities 304 of vertebral body 301 via the pedicle of vertebral arch 303 of vertebral body 301.In another implementation, two or more first slender members 101 are inserted via one or more pedicles of vertebral arch 303 of vertebral body 301.Perhaps, the step that first slender member 101 is inserted can comprise the sidewall of one or more first slender members 101 via vertebral body 301 is inserted in the internal cavities 304 of vertebral body 301.For example, first slender member 101 can be outer by pedicle of vertebral arch, the outside, back, side direction or the place ahead route insert; Perhaps insert by vertebral body 301 soleplates.In another implementation, the method step that first slender member 101 is inserted comprises first slender member 101 is inserted in the skeletal support structure that comprises bone, cartilage and sclerotin derivant thereof, film skeletonization and replacement bone.
As mentioned above, the device 100 that provides is used in skeletal support structure inside, and device 100 comprises expandable structures, and described expandable structures can comprise that at least one is configured to hold the tube chamber of radiation source.Shown in Fig. 4 A-D, device 100 can comprise expandable structures 103, it is configured to insert in the skeletal support structure and randomly is configured to and is connected with slender member, and described slender member for example is above-mentioned second slender member 102 (seeing Fig. 1,2A, 2B and 2D).
In another implementation, first and second expandable structures 200 and 201 comprise following material, and described material has performance or the characteristic that comprises compliance or non-compliance and combination thereof.Term used herein " compliance " is included in the pliability of elasticity, deployable property or flexible aspect.And term used herein " non-compliance " comprises rigidity, but depends on that concrete condition may not represent rigidity completely.By when making first expandable structures 200 and second expandable structures 201, changing the introducing of described material, can obtain different size, shape and the concordance of not unfolded and unfolded the one the second expandable structures 200 and second expandable structures 201.
In a kind of implementation, expandable structures 103 comprises the expandable material with interior lumen, and described expandable material is configured to be expanded to first shape and reversibly is expanded to second shape.Shown in Fig. 2 A-D, the expandable structures 103 of device 100 can comprise first expandable structures 200 and second expandable structures 201 that is arranged in first expandable structures 200.And first expandable structures 200 and second expandable structures 201 comprise inwall and sidewall.Can be (for example with material, fluid) introduces in the interior lumen (being shown main tube cavity 202 among Fig. 2 A-C), can cause fluid to push the inwall of second expandable structures 201 herein so that the expansion (effect) of expandable structures 103 (not shown) that comprise first expandable structures 200 and second expandable structures 201 to be provided.Shown in Fig. 2 A-C, between first expandable structures 200 and second expandable structures 201, be furnished with sublumen 203.In a kind of implementation, sublumen 203 is configured to hold material (for example fluid).Especially, the material that held of sublumen 203 can be a radiation source.
In a kind of implementation, first and second expandable structures 200 and 201 are configured to take out first expandable structures 200, second expandable structures 201 or both from the far-end (not shown) that installs 100 second slender member 102 is optional.For example, first expandable structures 200 can be configured to take out from installing 100, and wherein when taking out, second expandable structures 201 still is connected to second slender member 102 of device 100.Perhaps, second expandable structures 201 can be configured to take out from installing 100, wherein when taking out second expandable structures 201, first expandable structures 200 is connected with second slender member 102 of device 100.In a kind of implementation, the structure of expandable structures 103 forms pipe, sleeve pipe, bag, cover, capsule, bag, conduit or other suitable enclosed spaces.
In another implementation, expandable structures 103 comprises the expandable geometries (not shown) that is configured to reversibly expand to required form.The example of described expandable geometries includes but not limited to spiral, various types of spring and self-deploying support or stand.In a kind of implementation, device 100 further comprises the insertion sleeve pipe (not shown) that is configured to center on basically expandable structures 103.Inserting sleeve pipe can be used for placing and protecting expandable structures when expandable structures is taken out in skeletal support structure inside.During taking out pathological tissues or having contacted the apparatus of pathological tissues, insert sleeve pipe and can also protect tissue on every side.Insert sleeve pipe and can help prevent pathological tissues " sowing " its hetero-organization in the admission passage.
Shown in Fig. 4 A and 4B, expandable structures 103 comprises main tube cavity 202 and sublumen 203.Main tube cavity 202 can be configured to launch expandable structures 103, and sublumen 203 can be configured to hold radiation source (seeing Fig. 4 A and 4B).Perhaps, in another implementation, main tube cavity 202 can be configured to hold radiation source, and sublumen 203 is configured to launch expandable structures 103.
Shown in Fig. 4 A and 4B, at least one sublumen 203 is arranged essentially parallel to the major axis of second slender member 102 and arranges.And at least one sublumen 203 centers on expandable structures 103 along circumferential arrangement (seeing Fig. 4 A and 4B).Can use any multiple structure to come to arrange at least one sublumen 203 with respect to second slender member 102 and expandable structures 103.For example, can change sublumen (that is described at least one sublumen 203) thus number and orientation make holding of radiation source and carry optimization.
In a kind of implementation, expandable structures 103 comprises the one or more tube chambers by the radiation source co-manufactured.For example, can be by at least one sublumen 203 of radiation source co-manufactured.Perhaps, can be by radiation source co-manufactured main tube cavity 202.
Shown in Fig. 4 A-D, in a kind of implementation, at least one tube chamber 203 of expandable structures 103 comprises conduit 400, and conduit 400 is arranged in the expandable structures 103 and has opening 402 in the position near the far-end of expandable structures 103 basically.Opening 402 can hold lead or strengthen the passage of stylet (stiffening stylet).Conduit 400 comprises conduit cavity 401, and conduit 400 can stretch in second slender member 102 and extend the distance (seeing Fig. 4 A-D) of the length of second slender member 102 basically.In another implementation, at least one tube chamber 203 of expandable structures 103 does not comprise near opening or the outlet of far-end that is positioned at expandable structures 103.
Use the method for above-mentioned expandable structures 103 to comprise that wherein expandable structures 103 comprises at least one tube chamber that is configured to hold radiation source with in the expandable structures 103 insertion skeletal support structure; Launch expandable structures 103; And radiation source is delivered in the skeletal support structure via at least one tube chamber.In another implementation, this method also is included in deposition backing material in the skeletal support structure.Backing material can be bone cement (for example, polymethyl methacrylate (PMMA), pottery), people bone graft (autograft and allotransplant), the synthetic bone substitute that obtains, for example calcium sulfate, calcium phosphate and hydroxyapatite.In addition, in another implementation, backing material can comprise chemotherapeutant or radioactive agent.
In a kind of implementation, comprise that the device 100 of expandable structures 103 is configured to provide the Wicresoft that enters skeletal support structure insertion.For example, as shown in Figure 3, comprise that the device 100 of first slender member 101 and second slender member 102 comprises the Wicresoft's structure that is used in internal cavities 304 configurations of vertebral body 301.Described structure is a Wicresoft, (for example, passes pedicle of vertebral arch 303, will install as shown in Figure 3) 100 and introduce in the internal cavities 304 because only need to pass the passage aisle that skin and Musclar layer enter the desired area of vertebral body 301.Perhaps, invasive methods can be applied to the sidewall of vertebral body 301.For example, can be outer by pedicle of vertebral arch, the outside, back, side direction or the operation of the place ahead route or enter the desired area of vertebral body 301 by vertebral body 301 soleplates.Can include but not limited to bone, cartilage and sclerotin derivant thereof, film skeletonization and replacement bone to its other skeletal support structure of using Wicresoft's insertion route.
Numerous embodiments of the present invention has been described in the front.But, should be appreciated that under the prerequisite that does not deviate from the spirit and scope of the present invention and can make various improvement.Therefore, other embodiments also are encompassed in the scope of claims.
Claims (80)
1. device comprises:
First slender member, it has the tube chamber that is configured to provide the non axial passage that enters skeletal support structure inside; And
Second slender member, it is configured to therapeutic agent is delivered to skeletal support structure inside via described tube chamber.
2. the device of claim 1, wherein therapeutic agent is a radiation source.
3. the device of claim 1, wherein therapeutic agent is a chemotherapeutant.
4. the device of claim 1, wherein skeletal support structure is a bone.
5. the device of claim 1, wherein skeletal support structure is selected from cartilage and sclerotin derivant, film skeletonization and replacement bone.
6. the device of claim 1, wherein skeletal support structure is a vertebral body.
7. the device of claim 1, wherein second slender member has far-end, and described far-end comprises the expandable structures that is configured to enlarge the space in the skeletal support structure.
8. the device of claim 7, wherein expandable structures comprises radiation source.
9. the device of claim 7 further comprises being connected to second slender member and being configured to expandable structures to skeletal support structure delivered inside radiation dose.
10. the device of claim 9, wherein expandable structures comprises at least one tube chamber that is configured to hold radiation source.
11. the device of claim 9, wherein expandable structures comprises the ground floor and the second layer, and the described ground floor and the second layer are configured to hold radiation source between the two at it.
12. the device of claim 11, wherein the ground floor and the second layer are configured to hold radiation impermeability material between the two at it.
13. the device of claim 11, wherein the ground floor and/or the second layer comprise radiation impermeability material.
14. the device of claim 1, wherein second slender member comprises far-end, and it is remote visualization that described far-end is formed at skeletal support structure inside.
15. the device of claim 1, wherein first slender member comprises the device that is used to thrust skeletal support structure.
16. the device of claim 1, wherein one of first slender member and second slender member are configured to that further radiation source is positioned at the precalculated position.
17. the device of claim 14 wherein comprises one of at least the labelling that is configured to provide positional information in first slender member and second slender member.
18. the device of claim 1 further comprises radiation source, described radiation source is configured to provide the radiation dose that is positioned substantially at skeletal support structure inside.
19. the device of claim 18, wherein radiation source comprises radionuclide.
20. the device of claim 19, wherein radionuclide has the form that is selected from liquid, seed, pin, ball, granule and microsphere.
21. the device of claim 19, wherein radionuclide is selected from Au-198, Co-60, Cs-137, I-125, I-135, Ir-192, P-32, Pd-103, Ra-226, Rh-106, Ru-106, Sr-90 and Y-90.
22. the device of claim 1 further comprises the radiation shield that is configured to radioactive source shielding.
23. a method comprises:
First slender member that will have tube chamber non-axially is inserted into skeletal support structure inside, and described tube chamber limits the admission passage that enters skeletal support structure inside;
Second slender member is inserted in the tube chamber, and described second slender member is configured to skeletal support structure delivered inside radiation source; And radiation source is transported to skeletal support structure inside via tube chamber.
24. the method for claim 23 further comprises at least a portion of launching second slender member, thereby enlarges the space of skeletal support structure inside.
25. the method for claim 24 further comprises: in the space, deposit backing material.
26. the method for claim 25, wherein backing material is selected from bone cement, people's bone autograft, people's bone allotransplant, calcium sulfate, calcium phosphate and hydroxyapatite.
27. the method for claim 25, wherein backing material comprises chemotherapeutant.
28. the method for claim 25, wherein backing material comprises radioreagent.
29. the method for claim 23 is wherein carried the step of radiation source to comprise radiation source is placed on one or more stop places.
30. the method for claim 29 comprises further and determines one or more stop places that described position provides the radiation dose that is positioned substantially at skeletal support structure inside.
31. the method for claim 23, wherein the step that first slender member is inserted comprises the internal cavities that described device is inserted into vertebral body via the pedicle of vertebral arch of vertebral body.
32. device, comprise expandable structures with at least one tube chamber that is configured to hold radiation source, described expandable structures is configured to be inserted in the skeletal support structure, and further be configured to produce in skeletal support structure the space, described expandable structures comprises at least one tube chamber that is configured to hold radiation source.
33. the device of claim 32, wherein expandable structures is configured to be connected with slender member, is used for expandable structures is inserted in the skeletal support structure.
34. the device of claim 33, wherein at least one tube chamber is arranged essentially parallel to the slender member layout.
35. the device of claim 33, wherein slender member comprises first slender member and second slender member, and wherein second slender member is connected to expandable structures, and first slender member is configured to hold the expandable structures and second slender member.
36. the device of claim 35 further comprises the device that is used to thrust skeletal support structure, it is configured to hold first slender member.
37. the device of claim 32, wherein expandable structures comprises main tube cavity, and wherein at least one tube chamber comprises sublumen.
38. the device of claim 32, wherein at least one tube chamber be configured to slender member in tube chamber be fluid communication.
39. the device of claim 32, wherein expandable structures comprises:
Ground floor; With
The second layer, it is configured to hold radiation source between the ground floor and the second layer.
40. the device of claim 32, wherein expandable structures is configured to insert in the space, be expanded to deployed configuration and no longer launch after expansion in the space with deployed configuration not.
41. the device of claim 32, wherein expandable structures comprises the expandable material with interior lumen, and this expandable material is configured to be expanded to first shape and reversibly is expanded to second shape.
42. the device of claim 32, wherein expandable structures comprises the collapsible geometry that is configured to reversibly be expanded to required form.
43. the device of claim 32, wherein expandable structures is configured to enlarge the space in the internal cavities of vertebral body.
44. the device of claim 32 further comprises the insertion sleeve pipe that is configured to center on basically expandable structures.
45. the device of claim 32, wherein two or more tube chambers center on expandable structures along circumferential arrangement.
46. the device of claim 32, wherein expandable structures comprises:
First tube chamber; And
Second tube chamber, wherein first tube chamber is configured to launch expandable structures, and second tube chamber is configured to hold radiation source.
47. the device of claim 46, wherein first tube chamber and second tube chamber are configured to hold radiation impermeability material between the two at it.
48. the device of claim 32, wherein expandable structures comprises the one or more tube chambers with wall, and described wall is jointly by the radiation source manufacturing.
49. the device of claim 32, wherein expandable structures comprises the one or more tube chambers with wall, and described wall is made by radiation impermeability material jointly.
50. the device of claim 32 further comprises radiation source, and wherein at least one tube chamber is configured to hold radiation source.
51. the device of claim 32, wherein expandable structures comprises far-end, and at least one tube chamber is included in the conduit that has opening basically near the position of far-end.
52. the device of claim 32, wherein radiation source comprises radionuclide.
53. the device of claim 52, wherein radionuclide has the form that is selected from liquid, line, seed, pin, ball, granule and microsphere.
54. the device of claim 52, wherein radionuclide is selected from Au-198, Co-60, Cs-137, I-125, I-135, Ir-192, P-32, Pd-103, Ra-226, Rh-106, Ru-106, Sr-90 and Y-90.
55. a method comprises:
The expandable structures that is configured to be connected with slender member is inserted in the skeletal support structure, and described expandable structures comprises at least one tube chamber that is configured to hold radiation source;
Launch expandable structures; And
Radiation source is transported in the skeletal support structure via at least one tube chamber.
56. the method for claim 55 further is included in and deposits backing material in the skeletal support structure.
57. the method for claim 56, wherein backing material is selected from bone cement, people's bone autograft, people's bone allotransplant, calcium sulfate, calcium phosphate and hydroxyapatite.
58. a device comprises:
First expandable structures; And
Be arranged in second expandable structures in first expandable structures, first and second expandable structures are configured to enlarge the interior space of skeletal support structure and hold radiation source between the two at it.
59. the device of claim 58, wherein first expandable structures and second expandable structures are configured to realize relevant expansion relation between first expandable structures and second expandable structures.
60. the device of claim 59, wherein first expandable structures and second expandable structures are configured to optional first expandable structures or second expandable structures of taking out from device.
61. the device of claim 58, wherein first expandable structures and second expandable structures are no longer launched after being formed at and launching.
62. the device of claim 58, wherein expandable structures comprise have the compliance of being selected from, the material of the performance of non-compliance and combination thereof.
63. the device of claim 58, wherein first and second expandable structures are configured to enlarge the space in the internal cavities of vertebral body.
64. the device of claim 63, wherein the space that is provided when one or more expansion the in first and second expandable structures produces owing to spongy bone is compacted.
65. the device of claim 58 further comprises radiation source.
66. the device of claim 58, wherein first and second expandable structures are configured to insert in the space, be expanded to deployed configuration and no longer launch after expansion in the space with deployed configuration not.
67. the device of claim 58, wherein radiation source comprises radionuclide.
68. the device of claim 67, wherein radionuclide has the form that is selected from liquid, line, seed, pin, ball, granule and microsphere.
69. the device of claim 67, wherein radionuclide is selected from Au-198, Co-60, Cs-137, I-125, I-135, Ir-192, P-32, Pd-103, Ra-226, Rh-106, Ru-106, Sr-90 and Y-90.
70. the device of claim 58 wherein uses afterloader to hold radiation source in the space.
71. a method comprises:
First and second expandable structures are inserted into skeletal support structure inside, second expandable structures is arranged in first expandable structures, and first and second expandable structures are configured to enlarge the interior space of skeletal support structure and hold radiation source between the two at it;
Radiation source is provided; And
Radiation source is transported in the space of skeletal support structure inside.
72. the method for claim 71 comprises further that basically the expansion with first and second expandable structures is associated.
73. the method for claim 71 further comprises at least a portion of launching first and second expandable structures, thereby enlarges the space of skeletal support structure inside.
74. the method for claim 73 further is included in and deposits backing material in the space.
75. the method for claim 74, wherein backing material is selected from bone cement, people's bone autograft, people's bone allotransplant, calcium sulfate, calcium phosphate and hydroxyapatite.
76. the method for claim 74, wherein backing material comprises chemotherapeutant.
77. the method for claim 71 is wherein carried the step of radiation source to comprise radiation source is placed on one or more stop places.
78. the method for claim 77 further comprises and selects one or more stop places, so that the radiation dose that is positioned substantially at skeletal support structure inside to be provided.
79. the method for claim 71, the step of wherein first and second expandable structures being inserted skeletal support structure inside comprise the pedicle of vertebral arch of first and second expandable structures via vertebral body is inserted in the internal cavities of vertebral body.
80. a device comprises:
Have first slender member of tube chamber, described tube chamber is configured to provide the passage that enters skeletal support structure inside;
First expandable structures; And
Second expandable structures, it is arranged in first expandable structures, passes in the tube chamber that first and second expandable structures are configured to enlarge the space in the skeletal support structure and be configured for slender member.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/989,733 | 2004-11-15 | ||
| US10/990,291 | 2004-11-15 | ||
| US10/990,285 | 2004-11-15 | ||
| US10/989,733 US20050131267A1 (en) | 1995-06-07 | 2004-11-15 | System and method for delivering a therapeutic agent for bone disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101072600A true CN101072600A (en) | 2007-11-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200580041894 Pending CN101072600A (en) | 2004-11-15 | 2005-11-14 | System and method for delivering a therapeutic agent for bone disease |
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| Country | Link |
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| CN (1) | CN101072600A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178561A (en) * | 2011-03-14 | 2011-09-14 | 杨祚璋 | 125I particle-containing kit and application thereof |
| CN103126749A (en) * | 2012-12-08 | 2013-06-05 | 宁波市鄞州云帆工程咨询有限公司 | Air sac expansible and extensible anti-collapse implantation framework special for caput femoris |
-
2005
- 2005-11-14 CN CN 200580041894 patent/CN101072600A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178561A (en) * | 2011-03-14 | 2011-09-14 | 杨祚璋 | 125I particle-containing kit and application thereof |
| CN103126749A (en) * | 2012-12-08 | 2013-06-05 | 宁波市鄞州云帆工程咨询有限公司 | Air sac expansible and extensible anti-collapse implantation framework special for caput femoris |
| CN103126749B (en) * | 2012-12-08 | 2014-10-29 | 宁波市鄞州云帆工程咨询有限公司 | Air sac expansible and extensible anti-collapse implantation framework special for caput femoris |
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