CN100448466C - Medicine for preventing and auxiliary treating cancer - Google Patents
Medicine for preventing and auxiliary treating cancer Download PDFInfo
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- CN100448466C CN100448466C CNB021497435A CN02149743A CN100448466C CN 100448466 C CN100448466 C CN 100448466C CN B021497435 A CNB021497435 A CN B021497435A CN 02149743 A CN02149743 A CN 02149743A CN 100448466 C CN100448466 C CN 100448466C
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Abstract
The present invention discloses a medicine used for the prevention and the adjuvant therapy of cancer. The present invention is prepared from fermented Chinese caterpillar fungus powder, ganoderma and barbary wolfberry fruit, and has the functions of increasing organic immunity, adjusting incretion, removing detrimental free radicals in vivo, preventing tumor recurrence, etc. The present invention can also improve blood circulation and a hypercoagulative state of organisms, a stable internal environment can be maintained in vivo, and thereby, recrudescence and transfer of tumors can be prevented, and long-term therapeutic effect of patients with cancer can be improved.
Description
Affiliated technical field
The present invention relates to the medicine of a kind of prevention and auxiliary for treating cancer; Be the Chinese patent medicine of feedstock production specifically, the invention still further relates to the preparation method of this medicine with the Chinese herbal medicine.
Background technology
The treatment cancer is mainly taked methods such as operation, radiotherapy, chemotherapy, Chinese medicine auxiliary treatment, biotherapy both at home and abroad at present, and these methods all neither one can be treated method for cancer fully.Operation is fit to early stage less focus, and will strive for excising complete, has shifted the middle and advanced stage tumor of diffusion, and it is more harm than good to perform the operation, and at this moment, the purpose of operation is mostly to be for blocking of removing that tumor causes, complication such as hemorrhage.Radiotherapy has the effect of killing the local tumor cell, is first-selected Therapeutic Method for some to radiosensible tumor such as nasopharyngeal carcinoma etc., also is used for the pain management that neoplastic bone shifts pain in addition.The sequela of muscle, nerve injury is more after the radiotherapy, the recovery difficulty is big.Chemotherapy has general action, kinds of tumors all there is certain curative effect, can obviously dwindle tumor, control transfer and recurrence, but side effect is bigger, especially to the inhibition of bone marrow, make leukopenia, have certain risk, want the strict amount of drug of grasping, implement chemotherapy by the tumor medical practitioner.Biotherapy (claiming immunization therapy again) is new Therapeutic Method, goes to resist malignant tumor by inherent immune disease-resistance ability in the health.As interferon, interleukin-II etc., part tumor such as renal carcinoma, melanoma etc. are had certain curative effect, but price is expensive, many tumor efficiencies are imprecise.Traditional Chinese medical herbal treatment improves the immunologic function of human body with Chinese medicine, alleviate put, the toxicity of chemotherapy, improve curative effect etc.Chinese medicine has become the important means of treatment of cancer, rehabilitation.Chinese medicine can strengthen body immunity, suppress tumor growth, can also alleviate put, the side effect of chemotherapy, but to the lethality of tumor cell a little less than, short term effect is not as other therapies, but can be used as auxiliary treatment.Increasing data proves that immunodeficiency or reduction help cancer recurrence and transfer, and the cancer immunologic function that forms the back patient further is suppressed simultaneously, and can the quality of cancer patient immunologic function rehabilitation closely bound up with the patient.
Summary of the invention
The object of the present invention is to provide a kind of human body immunity improving power, endocrine there is regulating action, harmful free radical and prophylaxis of tumours recurrence etc. all have certain effect in the body to removing, can improve simultaneously the hypercoagulability of blood circulation and human body, make and keep a stable interior environment in the body, thereby prevent the recurrence and the transfer of tumor, the cancer prevention of the therapeutic effect at a specified future date of raising cancer patient and the medicine of auxiliary treatment.
Another object of the present invention provides the preparation method of the medicine of this cancer prevention and auxiliary treatment.
Solution of the present invention is based on motherland's medical science to cancer and pathogenetic understanding of complication and Therapeutic Principle, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out liver and kidney tonifying, mind tranquilizing and the heart calming, benefiting QI and nourishing blood, set upright training unit, the homologous natural edible-plant medicine of medicated diet, by the theory of Chinese medical science prescription, skim the cream off milk, its performance is strengthened the body cell immunity function, directly stimulate the T lymphopoiesis, the T lymphocyte is entered to be subjected in the thymus breaking up after the thymosin effect by small lymphocyte and forms.This class cell survival is grown (can survive more than 4 or five years), and quantity is more, is entered in the blood circulation by thymus, accounts for the 70-80% of blood medium-sized lymphocyte, can be the main cell that recirculates up to 95% in thoracic duct.The T lymphocyte is bodyguard loyal in the human body, bringing into play a kind of immunosurveillance of uniqueness, in a single day have the cancerous tumor cell of tumor specific antigen in the body, specially the T lymphocyte of this immunosurveillance of department just can be discerned foreign body, cause T lymphocyte sensitization, become the lymphocyte of sensitization, to many 25-1000 sensitized T lymphocyte enforcement attack doubly than cancerous tumor cell, cancerous tumor cell is killed, made it unlikely generation malignant tumor (some tumor Lock-out is exactly this reason).That is to say that medicine of the present invention takes before art, can control tumor, dwindle the tumor body, making it can only atrophy, can not develop, and by improving immune function of human body, gain time for successfully implementing operation, lays the foundation; Postoperative is taken, and can help patient's edge of a knife that heals, and regains one's strength, and eliminates the residual cancerous cell of human body, effectively prevents cancer return.
Medicine of the present invention is made by following component: (consumption is a weight portion)
Fermented Cordyceps powder 200～300 Ganodermas 200～300 Fructus Lycii 25～75
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Fermented Cordyceps powder 220～280 Ganodermas 220～280 Fructus Lycii 35～65
The optimum weight of medicine of the present invention (part) proportioning is:
Fermented Cordyceps powder 250 Ganodermas 250 Fructus Lycii 50
Above-mentioned each component is made medicine production method of the present invention is:
1, get fermented Cordyceps powder with 60% ethanol lixiviate secondary, each 12 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, relative density is 1.2～1.25 clear paste when being evaporated to 70～75 ℃;
2, get Ganoderma, decoct with water secondary, 2 hours each time, 1.5 hours for the second time, collecting decoction filtered, and relative density was 1.05～1.10 clear paste when filtrate decompression was concentrated into 70～75 ℃;
3, get Fructus Lycii with 70% ethanol lixiviate secondary, each 48 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, relative density is 1.2～1.25 clear paste when being evaporated to 70～75 ℃;
4, in described ratio above-mentioned clear paste is mixed, add dextrin and lactose mixing, make granule,, get final product to such an extent that the granule or the reuse common process of prevention and auxiliary for treating cancer makes the capsule medicine temperature drying below 75 ℃ 40～60 minutes with 14 mesh sieves.
Cordyceps and Ganoderma that an important feature of the present invention will have the title of " Herba mesonae chinensis " and " SHENCAO " exactly organically combine, make the bigger effect of its performance, because together with these two kinds of valuable ingredient of Chinese medicine prescriptions, it is can not self synthetic 8 kinds of essential amino acids content abundant to make medicament contain 18 seed amino acids, particularly human body such as a large amount of threonine, glutamic acid, alanine, leucine, serine, lysine, aspartic acid.Also contain the necessary vitamin A of normal life process, vitamin B1, B2, B6, B12, vitamin C, vitamin D and vitamin E simultaneously.Also contain trace element such as Se, Ca, Mn, Zn, Fe, Ge, Cu in addition; wherein Se (selenium) content is abundanter; selenium is the trace element of needed by human; be the active center of glutathione peroxidase, be connected on the peptide chain of pheron, protection cell membrane stability and normal permeability with the form of selenocystein; and energy immune stimulatory globulin and production of antibodies; enhancing human body immunity and oxidation resistance, the growth of anticancer reaches anticancer purpose by anti-gene mutation.Cordyceps polysaccharide in this medicament and ganoderan GLA, GLB, GLC can promote the T lymphopoiesis, improve serum IgG content, and the human body immunity improving function can also improve serum corticosterone, promote body nucleic acid and proteinic metabolism, thereby suppress tumor.Another effective component cordycepin is a kind of nucleosides material with antibacterial activity in this medicament, also has antitumaous effect.This medicament can also strengthen superoxide dismutase (SOD), catalase (CAT) vigor, effectively eliminates and suppresses cylinder super-oxidation lipid (LPO), removes the superoxide radical and the blood lactic acid of inducing generation, reaches defying age and antitumaous effect.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select the homologous natural edible-plant medicine of medicated diet for use be raw material in the present invention, and each component meets the Medicine Act regulation.Utilize the comprehensive function prevention and the auxiliary for treating cancer of the Chinese medicine of respectively distinguishing the flavor of, do not have chemical sweeting agent, nontoxic to human body.
2, the present invention need not decoct, and no bitterness sense is nutritious, and taking convenience meets national various Medicine Act regulation.
3, normal population of the present invention also can be taken, and takes for a long time, can play building body, and enhancing immunity and anti-cancer ability effectively prevent the sudden change of oncogene.
4, the cancer patient takes this medicament, but except enhancing human body immunity power, strengthen the T lymphopoiesis, outside the elimination cancerous cell, this medicament also has mind tranquilizing and the heart calming, improves the effect of sleep, thereby improves cancer patient's sleep quality, improving appetite, thus cancer patient's survival ability further improved.
For showing the adjuvant treatment effect of medicine of the present invention to cancer, the present invention is through the clinical observation of 52 routine systems, and selection medical history, the state of an illness, age, sex and suitable cancer patient 22 examples of former Therapeutic Method are matched group.Adopt the grouping of randomized controlled trial method to treat to be diagnosed as the cancer patient through biological tissue pathology and imageology, between treatment group age 32-83 year, the course of disease 1 month-19 years, between matched group age 30-81 year, the course of disease 2 months-12 years.Test group: on the former treatment basis, the inactive drug for increasing white cells of chemicotherapy patient and other tonics are obeyed medicine of the present invention.Matched group: take drug for increasing white cells and other tonics routinely.The employing same procedure is made regular check on, and three months observation periods, one month is a course of treatment, totally three courses of treatment.
Instructions of taking: 4g/ time, every day 2 times, ante cibum, boiled water was taken after mixing it with water.Clinical test results is as table.
Table one: medicine of the present invention is to the curative effect of different malignant tumor
| Group | Total routine number | Show routine number | Efficient | Good routine number | Efficient | There is not routine number | Efficient | Total effective rate | The P value |
| The treatment group | 52 | 11 | 21％ | 37 | 71％ | 4 | 8％ | 92.31％ | ＜0.05 |
| Matched group | 22 | 0 | 0 | 20 | 91％ | 2 | 9％ | 90.9％ |
As can be seen from the table, the total effective rate of medicine of the present invention is 92.31%, and matched group is 90.9%, and total effective rate is a little more than matched group, and takes medicine produce effects of the present invention 11 examples are arranged, and none example of matched group.
Table two: the cancer patient takes the variation of medicine of the present invention front and back performance status
Annotate:
0 grade of mobility is normal fully, does not have any difference with mobility before the onset;
1 grade of energy is freely walked about and is engaged in light physical exertion, comprises general housework or office work, but can not be engaged in moving than ass work;
2 grades of energy are freely walked about and are engaged in light physical exertion, but disablement, are no less than the half the time activity of can getting up in the daytime;
3 grades of lives only can partial self-help, time over half bed or wheelchair in the daytime;
Be unable to leave the bed, can't take care of oneself for 4 grades.
Improvement rate=routine the number that takes a turn for the better/total routine number, the performance status classification is fallen one-level or above person for taking a turn for the better after the medication.
As can be seen from the table, after the cancer patient takes medicine of the present invention, have patient's performance status of 30.8% that in various degree improvement is arranged, and the matched group patient have only 4.5% patient that improvement is arranged.
Table three: the cancer patient takes the variation of medicine of the present invention front and back total white blood cells
| Group | The example number | Before the treatment | After the treatment | The P value |
| The treatment group | 22 | 3.17±0.73 | 5.38±2.01 | ＜0.05 |
| Matched group | 8 | 3.23±0.96 | 4.57±1.88 | ＞0.05 |
Organize among the 52 routine patients in treatment, there are 22 routine patient's total white blood cellses to reduce, after taking medicine of the present invention, there is 20 routine patients' total white blood cells that in various degree rising is arranged, be that its improvement rate is 90.9%, 22 routine patients' leukocyte average also is significantly improved, contrast before and after the treatment, its difference significance.
Table four: the cancer patient takes medicine of the present invention front and back Immune Effects
Organize among the 52 routine patients in treatment, the OKT index occurred unusual before 21 routine patient treatments were arranged, after taking medicine of the present invention, there is 20 routine patients' OKT index that in various degree improvement is arranged, be that its improvement rate is 95.2%, this 21 routine patient's OKT index average then shows and increases, contrast before and after the treatment, its difference significance shows that this medicine can the enhancing human body immunity function.
The specific embodiment
Embodiment one
Take by weighing raw material (kilogram) by following proportioning
Fermented Cordyceps powder 250 Ganodermas 250 Fructus Lycii 50
Lactose 190 dextrin 45
Preparation method is as follows:
Get fermented Cordyceps powder with 60% ethanol lixiviate secondary, each 12 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, being evaporated to relative density is the clear paste of 1.2 (70 ℃).Get Ganoderma, decoct with water secondary, 2 hours each time, 1.5 hours for the second time, collecting decoction filtered, and filtrate decompression is concentrated into the clear paste that relative density is 1.05 (70 ℃).Get Fructus Lycii with 70% ethanol lixiviate secondary, each 48 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, being evaporated to relative density is the clear paste of 1.2 (70 ℃).Above-mentioned clear paste is mixed, add dextrin and lactose mixing, make granule,, make granule temperature drying below 75 ℃ 50 minutes with 14 mesh sieves.
Embodiment two
Take by weighing raw material (kilogram) by following proportioning
Fermented Cordyceps powder 200 Ganodermas 200 Fructus Lycii 25
Lactose 150 dextrin 30
Preparation method is as follows:
Get fermented Cordyceps powder with 60% ethanol lixiviate secondary, each 12 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, being evaporated to relative density is the clear paste of 1.2 (70 ℃).Get Ganoderma, decoct with water secondary, 2 hours each time, 1.5 hours for the second time, collecting decoction filtered, and filtrate decompression is concentrated into the clear paste that relative density is 1.05 (70 ℃).Get Fructus Lycii with 70% ethanol lixiviate secondary, each 48 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, being evaporated to relative density is the clear paste of 1.2 (70 ℃).Above-mentioned clear paste is mixed, add dextrin and lactose mixing, make granule,, make granule, again granule is made capsule with common process temperature drying below 75 ℃ 40 minutes with 14 mesh sieves.
Embodiment three
Take by weighing raw material (kilogram) by following proportioning
Fermented Cordyceps powder 300 Ganodermas 300 Fructus Lycii 75
Lactose 220 dextrin 70
Preparation method is identical with embodiment one.
Claims (5)
1, the medicine of a kind of prevention and auxiliary for treating cancer is characterized in that it being the medicament of being made by following materials of weight proportions:
Fermented Cordyceps powder 200～300 Ganodermas 200～300 Fructus Lycii 25～75
2, the medicine of prevention according to claim 1 and auxiliary for treating cancer, wherein the weight proportion scope of each raw material is:
Fermented Cordyceps powder 220～280 Ganodermas 220～280 Fructus Lycii 35～65
3, the medicine of prevention according to claim 1 and auxiliary for treating cancer, wherein the weight proportion of each raw material is:
Fermented Cordyceps powder 250 Ganodermas 250 Fructus Lycii 50
4,, it is characterized in that described medicament is granule or capsule according to the medicine of claim 1,2 or 3 described preventions and auxiliary for treating cancer.
5, the preparation method of the medicine of described prevention of claim 4 and auxiliary for treating cancer is characterized in that may further comprise the steps:
A, get fermented Cordyceps powder with 60% ethanol lixiviate secondary, each 12 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, relative density is 1.2～1.25 clear paste when being evaporated to 70～75 ℃;
B, get Ganoderma, decoct with water secondary, 2 hours each time, 1.5 hours for the second time, collecting decoction filtered, and relative density was 1.05～1.10 clear paste when filtrate decompression was concentrated into 70～75 ℃;
C, get Fructus Lycii with 70% ethanol lixiviate secondary, each 48 hours, merge lixiviating solution, filter, behind the decompression filtrate recycling ethanol, relative density is 1.2～1.25 clear paste when being evaporated to 70～75 ℃;
D, above-mentioned clear paste is mixed, add dextrin and lactose mixing, make granule,, get final product to such an extent that the granule or the reuse common process of prevention and auxiliary for treating cancer makes the capsule medicine temperature drying below 75 ℃ 40～60 minutes with 14 mesh sieves in described ratio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021497435A CN100448466C (en) | 2002-12-25 | 2002-12-25 | Medicine for preventing and auxiliary treating cancer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021497435A CN100448466C (en) | 2002-12-25 | 2002-12-25 | Medicine for preventing and auxiliary treating cancer |
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| Publication Number | Publication Date |
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| CN1509760A CN1509760A (en) | 2004-07-07 |
| CN100448466C true CN100448466C (en) | 2009-01-07 |
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| CNB021497435A Expired - Fee Related CN100448466C (en) | 2002-12-25 | 2002-12-25 | Medicine for preventing and auxiliary treating cancer |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102551058A (en) * | 2012-01-17 | 2012-07-11 | 北京东方红航天生物技术股份有限公司 | Chinese medicinal health-care product with function of enhancing immunity |
| CN103446201B (en) | 2012-05-29 | 2017-11-24 | 江中药业股份有限公司 | A kind of composition for preventing and treating anaphylactia and preparation method thereof |
| CN103494197A (en) * | 2013-10-09 | 2014-01-08 | 吉林省现代中药工程研究中心有限公司 | Health-care food with functions of enhancing immunity and assisting to reduce blood sugar and preparation method of food |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144047A (en) * | 1995-08-25 | 1997-03-05 | 汪景山 | Instant tea made of Chinese caterpillar fungus and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144047A (en) * | 1995-08-25 | 1997-03-05 | 汪景山 | Instant tea made of Chinese caterpillar fungus and its preparation method |
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