CN100438839C - Jet impulse type brain refrigerating device - Google Patents
Jet impulse type brain refrigerating device Download PDFInfo
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- CN100438839C CN100438839C CNB200610083825XA CN200610083825A CN100438839C CN 100438839 C CN100438839 C CN 100438839C CN B200610083825X A CNB200610083825X A CN B200610083825XA CN 200610083825 A CN200610083825 A CN 200610083825A CN 100438839 C CN100438839 C CN 100438839C
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- medicated cap
- jet impulse
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Abstract
The present invention relates to one kind of brain cooling jet impact device, which has a booster pump to pressurize the cooling medium, a cooling cap jet passage and an oral cavity pouring passage for jetting cooling medium to cool down the selected target tissue in brain quickly, an elevating bed fore required height and angle regulation, temperature sensors for taking the surface temperature and the core temperature of the patient, and a computer with treating software receiving the measured temperatures and regulating the pressure, temperature and other parameters of the cooling medium for reaching required treatment effect. The present invention has high cooling effect, automatic operation and other advantages.
Description
Technical field
The present invention relates to a kind of device that can realize fast cooling to deep tissue in the brain, be particularly related to and a kind ofly impact scalp strengthening heat exchange and to be aided with oral cavity injection infusate flow, thereby realize jet impulse type brain refrigerating device rapidly the selective fast cooling of cerebral tissue by means of liquid jet.
Background technology
As everyone knows, brain is the most important organ of function and conscious activity of earning a bare living.The cerebral tissue oxygen consumption is big, the blood flow height, and metabolism is vigorous.Under rest state, the every hectogram cerebral tissue of cerebral blood flow is 50～60ml/min, though Adult Human Brain approximately only percentage of liveweight 2%, blood flow accounts for about 15% of heart row output, oxygen consumption then accounts for 20% of whole body oxygen consumption.For this reason, need lasting blood oxygen and energy supply, cerebral blood flow is to guarantee that brain carries out the essential condition of normal physiological activity.When severe depletion of oxygen occurring and carbon dioxide gathers; can cause the organism metabolism obstacle; acid-base value and electrolyte take place to be changed; cause that finally intracellular plastochondria and lysosome break; directly cause cell death and self-dissolving; body enter the biological death stage (Jiang Jiyao. inferior hypothermia cerebral protection basis is with clinical. Shanghai: publishing house of The 2nd Army Medical College, 1998).At this moment, oxygen supply deficiency when anoxia overlong time or lung recovery causes the danger of possible permanent damage also just to respond to brain and increases.
A large amount of clinical experiments is verified, gives the brain low temperature therapy in the cardio-pulmonary resuscitation process, can significantly alleviate the extent of damage of cerebral tissue neuron pathology form, obviously improves and promote the brain function recovery.The definite curative effect and the safety of low temperature cerebral resuscitation are familiar with by various countries' neurosurgeon gradually, and promote the use of in many hospitals.In recent years, the various countries scholar cooperates at cooling degree, method, persistent period and medicine and avoids complication etc. to do positive exploration, and on this problem of the low temperature recovery degree of depth, reach unified common recognition substantially, promptly be advisable with the inferior low temperature of about 30 ℃ of body surfaces.And cooling begins more early good more, and it is quite crucial especially whether in time to implement low temperature in initial 15 minutes.Certainly, rely on the control physical condition can not effectively make the patient recover physical function fully far away merely.Therefore, be equipped with at different low temperature revival phases that suitable medicine or other physical means are supported to each life organ function and to keep homeostasis very important.So the low temperature composite treatment just becomes a focus of rising in recent years.
So far, all kinds of typical brain cooling means roughly comprise following a few class: 1, extracorporeal circulation method: carotid artery blood is drawn out to the outside is lowered the temperature; This method is traumatic bigger; 2, blood vessel internal cooling method: fine refrigeration probe is inserted blood vessel implement directly cooling, but there is operating difficulties in this method, the Instrument Manufacturing Technique complexity; 3, contact cooling: based on certain cryogenic media such as the ice blanket behind the semiconductor refrigerating brain scalp is implemented cooling, the cooling effectiveness of this method is limited; 4, body surface convection current cooling: by means of the cooling water that flows through head brain is implemented cooling, the cooling effectiveness of this method is also limited; 5, nasal cavity cold air cooling: be that gas after the cooling or gas-liquid-solid coexisting body (as containing ice crystal cold air) are driven into nasal cavity enforcement cooling, but cooling-down effect is limited; 6, space cooling: with cryogenic liquid by transfusion mode or be injected directly into destination organization and implement cooling, the application of this method has certain limitation.Generally, a large amount of early-stage Study show that all kinds of cooling means exist such-and-such advantage or deficiency; surface cool only has superiority in cooling body table organization; and not good, but, in the brain protection, be still method with the most use at present owing to implement convenient, safety to the cooling effect of deep tissue.If can promote its efficient on this basis, then can develop and the efficient easily cerebral tissue heat sink of use.
The current surface-cooled brain protective measure of analysis-by-synthesis, as can be seen, two key issues that restrict this class methods cooling effectiveness are: on the one hand, surperficial convection transfer rate is too small, causes the rate of temperature fall of brain inner tissue rapid inadequately; On the other hand, the cooling of taking at present mainly is limited to body surface, and the area of catching a cold is limited, thereby fails to realize to greatest extent the fast cooling to brain inner tissue.For this reason, the invention provides a kind of jet impulse type brain cooling means and device,, be aided with the oral cavity perfusion simultaneously brain inner tissue is directly implemented cooling with remarkable lifting body surface convection transfer rate by means of the jet impulse scalp, thereby realize rapidly the brain internal object is organized selectively cooling fast.Jet impulse type brain cooling means provided by the invention and device have easy and simple to handlely, can realize selectivity cooling, to characteristics such as patient's invasive are little.
Summary of the invention
The objective of the invention is to: a kind of jet impulse type brain cooling means and device are provided, promptly by means of the jet impulse scalp with remarkable lifting body surface convection transfer rate, be aided with simultaneously to pour in the oral cavity brain inner tissue is implemented cooling, thereby realize the selective quick cooling of brain destination organization rapidly.This method operation is very easy, cooling efficient height, and use cost is low, and human body is had no adverse effect.Comparatively favourable in clinical practice.
Technical scheme of the present invention is as follows:
Jet impulse type brain refrigerating device provided by the invention comprises:
Cold medicated cap 9, refrigerating plant 41 and Computer Control Unit 11; It is characterized in that, be provided with at least one its inlet in the air chamber 93 that limits between the shell medicated cap 92 of described cold medicated cap 9 and the interior medicated cap 91 and be located on the shell medicated cap 92, the jet impulse passage 19 in outlet is located on the medicated cap 91; The porch of described jet impulse passage 19 is equipped with the cold medium inlet pipe that is connected with the outfan of refrigerating plant 41; Described shell medicated cap 92 is provided with the medium back flow passage 39 that is connected with described air chamber 93; Be filled with sealing filled media 49 between the preceding upper end of described cold medicated cap 9 and the shell medicated cap 92 of preceding bottom and the interior medicated cap 91 respectively;
The outfan of described refrigerating plant 41 is connected with cold medium inlet tube inlet on the jet impulse passage 19 by flow control valve 6;
Described medium back flow passage 39 leads to the medium back flow coated lycopene by keying valve 5 or links to each other with driving pump 2 by opening and closing valve 5, recycles so that reflux medium participates in;
At described cold medicated cap 9 inner surfacies pick off is installed, described pick off is electrically connected with the control device 7 of Computer Control Unit 11, to control the temperature of jet fluid in the cold medicated cap 9;
Described Computer Control Unit 11 is made up of computer 10, control device 7 and external interface, and described computer 10 is PC or single-chip microcomputer.
Described refrigerating plant 41 carries out refrigerating steam compressing refrigerating device for adopting freon series, ammonia, carbon dioxide or lithium bromide refrigerating agent; Perhaps for adopting the thermoelectric cooling unit of semiconductor refrigerating; The temperature of its gaseous refrigerant is controlled between-190～30 ℃; The temperature of liquid refrigerant then is controlled between-10～30 ℃.
The refrigerant of refrigerating plant 41 is tap water, saline, cold air, nitrogen or oxygen.
Described driving pump 2 is pressure pump, electromagnetic pump or gas pressurized pump.
Described shell medicated cap 92 is the shell medicated cap of carbon steel, copper, aluminum, rustless steel or plastic material.
Described cold medium inlet pipe is plastic-aluminum pipe, plastic tube or steel pipe; Just be coated with adiabator layer on the face outside it.The cross section of described jet impulse passage 19 is circle, rectangle, square or oval; Sectional area is 1mm
2-100mm
2Described jet impulse passage 19 length are 10mm-1000mm; Described jet impulse passage 19 is the passage of rustless steel, pyrite, red copper or carbon steel material;
As everyone knows, traditional ice cap is encapsulated in ice cap inside to frozen water, and the air gap between ice cap and the patient's head becomes the biggest obstacle that heat transmits.For strengthening heat-transfer effect, cold medicated cap and head are pressed close to.And the result who does like this may make low temperature frozen water cold injury patient again.So, reduce thermal resistance and prevent that cold injury from being the unsurmountable contradiction of traditional ice cap.Reinforcement cooling means of the present invention is mainly impacted convection current by the contact of cold medium and cooling end interdigit and is realized that the more traditional ice cap of its convection transfer rate increases greatly.Particularly, coolant temperature is adjustable, can be with whole brain protection process control in non-cold injury temperature range.Both reach the purpose that cools fast, and can not cause cold injury again.Easily solve the deficiency of traditional ice cap.
In the use, cryogen can adopt multiple liquid state or gaseous working medium, can be water, ethanol or more non-toxic organic solution such as liquid medium, gaseous working medium can be the low-temperature carbon dioxide of dry ice generation, the cryogenic nitrogen steam that liquid nitrogen vaporization produces, the cryogenic oxygen that the liquid oxygen evaporation produces etc.The working medium kind can have different embodiments not simultaneously.Such as, the work process of gaseous working medium is: the high-pressure working medium in the gas bomb can enter the refrigeration machine cooling under self pressure effect, arrive the inherent brain of cold medicated cap surface afterwards and carry out the jet impulse heat exchange.After the working medium heat absorption, enter the return flow line, can directly emit, or recycle again.Liquid refrigerant work process and gaseous state cryogen major different are that liquid refrigerant needs the driving by means of force (forcing) pump.In the cooling procedure, cold medium temperature, pressure can be adjusted under the monitoring of computer as required, to satisfy the different needs under the different treatment conditions.Above-mentioned therapeutic process need to adopt the lifting bed, meets physiology's requirement with the arrangement of adjusting patient's brain, and the lifting bed height, the position can be by the random adjustment of patient's requirement.
Before the treatment, the clinicist is worn on patient's head with cooling headgear, simultaneously, cooling water circulation pipeline ejector is inserted the oral cavity; Afterwards, open pipeline, then the cooling water nozzle that reaches in the pipeline in the cooling headgear is ejected into head outer surface and oral cavity inner surface with cooling water, thereby implements the efficient cooling to brain.After the certain time, watch the number that need stop or changing jet velocity and injector head.Thus, can realize selectivity and controllability cooling to cerebral tissue.
In the real process, can arrange a plurality of playpipes simultaneously at some position of body surface, and be fixed according to refrigerating capacity and cooling position needs; Also can in the oral cavity, insert many injector heads in many places, to adjust the position and the intensity of cooling.So,, can adjust the cooling situation of brain neatly by means of this injector head that is decorated in array.Because this cooling realizes by means of the impact mode, thereby heat exchange efficiency is very high.This method is compared with external convection current cooling method in the past, and its advantage is that the coefficient of heat transfer is promoted greatly; And owing to increased oral cavity perfusion cooling, the refrigerative speed of its brain is faster.Thereby this is a kind of effectively brain cooling means.
It is worthy of note, arrange a large amount of injector head arrays in pairs, thereby can adjust cooling intensity by the cooperation between the injector head owing to adopt at body surface.
Being also advantageous in that of patent of the present invention, to patient's not damaged, cooling rapidly.Because increased oral cavity perfusion cooling, thereby can realize the harmless cooling to deep-brain to greatest extent, the cooling amount can be adjusted as required.This class clinical operation can carry out at general out patient service, and it is quite convenient that this makes based on the enforcement of the brain cooling first aid mode of apparatus of the present invention.
Description of drawings
Shown in Figure 1 is the structure of jet impulse type brain refrigerating device of the present invention and the sketch map that uses attitude.
Fig. 2 is a cold cap sketch map of the present invention.
The specific embodiment
Further describe the present invention below in conjunction with drawings and the specific embodiments.
Fig. 1 is the structure of jet impulse type brain refrigerating device of the present invention and the sketch map that uses attitude.Therefrom as seen, this jet impulse type brain refrigerating device comprises: liquid refrigerant 1; Driving pump 2; Gaseous state cryogen storage tank 3; Refrigeration machine 4; Open and close valve 5; Flow control valve 6; Controller 7; Temperature sensor; Cold medicated cap 9 and liftable bed; The cold medicated cap 9 of wherein being furnished with jet impulse passage 19 is these core technologies of inventing cold medicated cap different from the past.Described cold medicated cap 9 comprises by interior medicated cap 91 and shell medicated cap 92, and the air chamber 93 that limits between interior medicated cap 91 and the shell medicated cap 92; Be provided with 1-100 jet impulse passage 19 in the air chamber 93 of described cold medicated cap, each jet impulse passage is provided with cold medium inlet and outlet separately; It is 1mm that cold medium is imported and exported caliber
2-1000mm
2The cross section of jet impulse passage 19 is circle, rectangle, square or oval, and area of section is 1mm
2-100mm
2 Jet impulse passage 19 length are 10mm-1000mm; Jet impulse passage 19 is the passage of rustless steel, pyrite, red copper or carbon steel material; Shell medicated cap 92 can be the rigid crust medicated cap of materials such as carbon steel, rustless steel, copper, aluminum or plastics.Cold cap surface should have good heat-insulating property.About refrigerating plant, can adopt the vapour compression refrigerator as conventional refrigerator, or thermoelectric refrigerator.Wherein, vapour compression unit can adopt freon series, ammonia, carbon dioxide, cold-producing mediums such as lithium bromide; The electricity refrigerating plant also can adopt the thermoelectric cooling unit based on semiconductor technology.Refrigerant temperature control can be adjustable arbitrarily between-190～30 ℃.The cold medium that is used for lowering the temperature with the brain surface can adopt various heat-carrying agents such as tap water, saline, cold air, nitrogen or oxygen.Cold medium is reusable, also can drain after heat absorption.Shell medicated cap 92 can adopt high thermal conductivity coefficient materials such as copper, aluminum, rustless steel to manufacture.The cryogen conveyance conduit can be with materials such as plastic-aluminum pipe, plastic tube, steel pipes, and at its outside covering insulation material.In addition, Computer Control Unit can be made up of computer and external interface device, and computer can adopt PC, industrial computer or single-chip microcomputer.
Use the detailed process of apparatus of the present invention to be, the gaseous state cryogens enter transfer passage in the gas bomb 3 under self pressure effect, lower the temperature refrigeration machine 4 in, enter jet impulse passage 19 ejection at a high speed of cold medicated cap afterwards, do strong heat exchange in the tract between human brain and cold medicated cap.After the cold medium heat absorption, discharge through reflux pipeline.The difference of liquid refrigerant and gaseous state cryogen is that liquid refrigerant needs the pump pressurization.Its force (forcing) pump can adopt small-sized driving pump and the realizations of all gases force (forcing) pump such as electromagnetic pump, micro pump.Control device can be made up of catalyst, relay, converter, electric wiring, and control procedure is finished by the therapy plot software of prepackage.
Fig. 2 is cold cap sketch map.Cold medicated cap 9 comprises by interior medicated cap 91 and shell medicated cap 92, and the air chamber 93 between interior medicated cap 91 and the shell medicated cap 92; 1-100 its inlet is set in the air chamber 93 is located on the shell medicated cap 92, the jet impulse passage 19 in outlet is located on the medicated cap 91; Medium back flow passage 39; The described air chamber 93 that is positioned at human brain forehead place and neck is filled with sealing filled media 49; Jet impulse feeder connection on the shell medicated cap 92 of cold medicated cap 9 is equipped with inlet tube; Filling plastic cement flexible material between the jet impulse passage 19 described in the air chamber 93 is to guarantee tightly not leaking of cold medium.The side of cold medicated cap 9 is provided with a plurality of cold medium back flow passages 49, makes to reclaim smoothly after the heat absorption of cold medium or drain.Cold medicated cap 9 itself should adopt rigid material such as the plastics with certain intensity.
Apparatus of the present invention can be arranged into head or/and the oral cavity to playpipe with many, thereby by the effect of impact jet flow, come rapidly the brain internal object to be organized fast cooling selectively.Cryogen arrives oral cavity and cold medicated cap fluidic channel inlet under the promotion of force (forcing) pump, ejection is at a high speed carried out strong heat exchange at brain outer surface and oral cavity inner surface afterwards, reduces brain temperature rapidly.Cryogen heat absorption back temperature raises, and enters reflux pipeline, heat release in refrigeration machine, and cooling after the pump pressurization, circulates next time.In the work process, be arranged on patient oral cavity, axillary fossa or intrarectal temperature sensor and respectively patient oral cavity, axillary fossa or rectal temperature monitored, and give computer signal feedback, computer adjusts refrigerant temperature.In the operating process, the lifting bed can be adjusted height and angle as required, to satisfy the operation needs.The routine operation process is as follows:
1. nurse or doctor prepare before doing conventional art, check that pipeline connects, and gaseous state cryogen and liquid refrigerant pressure as insufficient pressure, in time replenish cryogen.Energized is opened computer, starts refrigeration system and force (forcing) pump, and refrigerant temperature is monitored.
2. patient keeps flat to the lifting bed, adjusts patient body position and head angle, so that operation.
3. the cold medicated cap 9 of jet impulse is fixed in patient's head, guarantees tightly not leak, and oral cavity fill up line and shower nozzle are adjusted to the appropriate location.
4. after preparation finishes, open driving pump 2, brain is carried out the jet impulse cooling, can pour into the oral cavity simultaneously, strengthen cooling effect.
5. in time adjust pressure, temperature parameter according to the temperature sensor feedback signal.
6. in to the brain cooling procedure, can do in other art and handle.
Claims (8)
1, a kind of jet impulse type brain refrigerating device comprises:
Cold medicated cap (9), refrigerating plant (41) and Computer Control Unit (11); It is characterized in that be provided with at least one its inlet in the air chamber (93) that limits between the shell medicated cap (92) of described cold medicated cap (9) and the interior medicated cap (91) and be located on the shell medicated cap (92), outlet is located at the jet impulse passage (19) on the interior medicated cap (91); The porch of described jet impulse passage (19) is equipped with the cold medium inlet pipe that is connected with the outfan of refrigerating plant (41); Described shell medicated cap (92) is provided with the medium back flow passage (39) that is connected with described air chamber (93); Be filled with sealing filled media (49) between the shell medicated cap (92) of the preceding upper end of described cold medicated cap (9) and preceding bottom and the interior medicated cap (91) respectively;
The outfan of described refrigerating plant (41) is connected with cold medium inlet tube inlet on the jet impulse passage (19) by flow control valve (6);
Control device (7) outfan of Computer Control Unit (11) is connected with flow control valve (6), with the cold of control by flow control valve (6) output;
Control device (7) outfan of Computer Control Unit (11) also is connected with refrigerating plant (41) simultaneously, with the cryogenic temperature of control refrigerating plant (41);
Described medium back flow passage (39) leads to the medium back flow coated lycopene by keying valve (5) or links to each other with driving pump (2) by opening and closing valve (5), recycles so that reflux medium participates in;
At described cold medicated cap (9) inner surface pick off is installed, described pick off is electrically connected with the control device (7) of Computer Control Unit (11), to control the temperature of the interior jet fluid of cold medicated cap (9);
Described Computer Control Unit (11) is made up of computer (10), control device (7) and external interface, and described computer (10) is PC or single-chip microcomputer.
By the described jet impulse type brain refrigerating device of claim 1, it is characterized in that 2, described refrigerating plant (41) carries out refrigerating steam compressing refrigerating device for adopting freon series, ammonia, carbon dioxide or lithium bromide refrigerating agent; Perhaps for adopting the thermoelectric cooling unit of semiconductor refrigerating; The temperature of its gaseous refrigerant is controlled between-190～30 ℃; The temperature of liquid refrigerant then is controlled between-10～30 ℃.
3, by the described jet impulse type brain refrigerating device of claim 1, it is characterized in that: the refrigerant of refrigerating plant (41) is tap water, saline, cold air, nitrogen or oxygen.
4, by the described jet impulse type brain refrigerating device of claim 1, it is characterized in that: described driving pump (2) is pressure pump, electromagnetic pump or gas pressurized pump.
5, by the described jet impulse type brain refrigerating device of claim 1, it is characterized in that: described shell medicated cap (92) is the shell medicated cap of carbon steel, copper, aluminum, rustless steel or plastic material.
6, by the described jet impulse type brain refrigerating device of claim 1, it is characterized in that: described cold medium inlet pipe is plastic-aluminum pipe, plastic tube or steel pipe; Just be coated with adiabator layer on the face outside it.
7, by the described jet impulse type brain refrigerating device of claim 1, it is characterized in that: the cross section of described jet impulse passage (19) is circle, rectangle, square or oval; Sectional area is 1mm
2-100mm
2
8, by the described jet impulse type brain refrigerating device of claim 1, it is characterized in that: described jet impulse passage (19) length is 10mm-1000mm; Described jet impulse passage (19) is the passage of rustless steel, pyrite, red copper or carbon steel material;
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610083825XA CN100438839C (en) | 2006-06-01 | 2006-06-01 | Jet impulse type brain refrigerating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610083825XA CN100438839C (en) | 2006-06-01 | 2006-06-01 | Jet impulse type brain refrigerating device |
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| CN101081187A CN101081187A (en) | 2007-12-05 |
| CN100438839C true CN100438839C (en) | 2008-12-03 |
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| CNB200610083825XA Expired - Fee Related CN100438839C (en) | 2006-06-01 | 2006-06-01 | Jet impulse type brain refrigerating device |
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Families Citing this family (7)
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| CN103006344B (en) * | 2012-12-05 | 2014-12-03 | 山东大学 | Semiconductor refrigerating frostbite model instrument |
| CN103190981A (en) * | 2013-02-27 | 2013-07-10 | 河南省华氏实业有限公司 | Low temperature therapeutic apparatus |
| CN203539516U (en) * | 2013-11-04 | 2014-04-16 | 曾建晖 | Medical cold compress machine |
| CN104188748B (en) * | 2014-09-15 | 2017-01-11 | 汕头大学医学院第一附属医院 | Light type cold compress device |
| CN104473714A (en) * | 2014-12-08 | 2015-04-01 | 刘思伯 | Extravascular cooling and mild hypothermia treatment control system and application thereof |
| CN104921929B (en) * | 2015-07-02 | 2017-03-01 | 中国人民解放军第四军医大学 | A kind of mask of scalable laser therapy rear face cooling |
| CN108523864A (en) * | 2018-04-18 | 2018-09-14 | 郭旭丽 | A kind of multinomial data monitoring therapeutic device of paediatrics |
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| CN2080391U (en) * | 1990-10-21 | 1991-07-10 | 刘国祥 | Multifunction cold effect brain protection instrument |
| CN2188363Y (en) * | 1994-03-11 | 1995-02-01 | 刘江齐 | Head semiconductor physical cooling instrument |
| US6277143B1 (en) * | 1991-05-22 | 2001-08-21 | Life Science Holdings, Inc. | Brain cooling apparatus and method for cooling the brain |
| CN1088574C (en) * | 1995-11-03 | 2002-08-07 | 复旦大学 | Method and apparatus for local temp. reducing of brain circulation system |
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2006
- 2006-06-01 CN CNB200610083825XA patent/CN100438839C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2080391U (en) * | 1990-10-21 | 1991-07-10 | 刘国祥 | Multifunction cold effect brain protection instrument |
| US6277143B1 (en) * | 1991-05-22 | 2001-08-21 | Life Science Holdings, Inc. | Brain cooling apparatus and method for cooling the brain |
| CN2188363Y (en) * | 1994-03-11 | 1995-02-01 | 刘江齐 | Head semiconductor physical cooling instrument |
| CN1088574C (en) * | 1995-11-03 | 2002-08-07 | 复旦大学 | Method and apparatus for local temp. reducing of brain circulation system |
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