CN100434033C - Power measurement arrangement for animal movement - Google Patents

Power measurement arrangement for animal movement Download PDF

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Publication number
CN100434033C
CN100434033C CNB2004101551101A CN200410155110A CN100434033C CN 100434033 C CN100434033 C CN 100434033C CN B2004101551101 A CNB2004101551101 A CN B2004101551101A CN 200410155110 A CN200410155110 A CN 200410155110A CN 100434033 C CN100434033 C CN 100434033C
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China
Prior art keywords
power measurement
animal movement
measurement arrangement
animal
data processing
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Expired - Fee Related
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CNB2004101551101A
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Chinese (zh)
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CN1704019A (en
Inventor
陆融
林刚
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SHEN ZHEN KANGZHE PHARMACEUTICAL CO Ltd
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SHEN ZHEN KANGZHE PHARMACEUTICAL CO Ltd
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Publication of CN1704019A publication Critical patent/CN1704019A/en
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Abstract

The present invention relates to a power testing device of animal movement, which comprises rotating wheels and detection devices, wherein the rotating wheels have fixing resistance moments, and the detection device comprise sensors and counters connected with the output of the sensors; the numbers of the rotating wheels, the sensors and the counters are respectively two, each rotating wheel is corresponding to a sensor and a counter, the detection devices also comprise a data processing device connected with the counters, each sensor senses angular displacement moving signals corresponding to the rotating wheels during the movement of animals the moving signals are inputted into the corresponding counters, and the data processing device receives and processes data inputted by all the counters. The power testing device can realize the centralized management for animal experiments, the purposes that a plurality of experiments are managed by one device and use a set of monolithic computer system can be achieved, and the cost performance of the device is effectively enhanced; furthermore, because a plurality of power testing parts realize high frequency experiments, a testing result is more accurate.

Description

Power measurement arrangement for animal movement
[technical field]
The present invention relates to animal experiment device capable, especially about a kind of power measurement arrangement for animal movement.
[background technology]
In medicine and biochemical test, often utilize zoopery check efficiency of drugs, this check is to change by the quantity of motion of animal under drug effect to understand drug effect.The conventional animal experimental technique has animal treadmill and swimming test method, and the common feature of these two kinds of experimental techniques is to observe the ability that animal is finished a certain amount of work within a certain period of time and finishes certain workload.
Animal treadmill test method is to allow animal finish a certain amount of moving with certain speed, as the quantity of motion of the merit metering animal of being finished; The swimming test method is the pond that animal is placed uniform temperature, animal is swum in the water or keeps the merit that balance action is done, as the quantity of motion of the merit metering animal of being finished.The existing common feature of method of these two kinds metering animal movement amounts is: all can only measure " merit " that it is done by the average case of animal motion, being limited to laboratory facilities simultaneously can not measure resulting result with standard volume, can only come proximate expression animal cardinal principle kinergety at the volley to consume with one " amount of ambiguous merit ", thereby the result who measures only has the meaning on the statistics, the statistical analysis that resulting measuring result can only change with the variation and the population mean quantity of motion of individual movement difference.
The practical alternative animal treadmill and the method for swimming test are: based on utilizing animal movement to make the method for the wheel rotation metering animal movement institute work of fixed resistance square.Though this method also exists the amount that can not utilize accurate mechanics to express the shortcoming of animal movement institute work accurately, can measure the relative motion amount of animal at least more accurately.Its principle is: make animal have in the wheel of the condition of climbing up by holding on at the wheel wall and move, make the wheel rotation, the action of animal overcomes the moment of resistance acting of " wheel ", represents the quantity of motion of animal by measuring the merit of being done when animal movement overcomes the resistance of wheel.
The report the earliest of this experimental technique starts from 1992, and the U.S. need carry out quantized device to the fatigue state of animal for the pathogenesis of research chronic fatigue syndrome.The Minn. medical research center please design this counting assembly by M.Gekkr in 1992; this device is fixed in the mouse cage top; mice freely drinks and is free movable, climbs the strong person's character of curiosity according to the rodent happiness, adopts 24 hours normal activity of mechanical counter record mice.This experimental data shows that under the normal condition, 24 hours quantity of motion of Bala/c female mice is 14,582+2599 foot, C57/BL female mice 16,207+3797 foot.
But the defective that above-mentioned two kinds of experimental techniques exist is: one, these two kinds of methods all are to adopt the method for mechanical measurement of power, write down angular displacement by mechanical counter, so a part of merit that animal is cooked will be used for the driving device enumerator and count, and then makes the low and inefficiency of precision as a result of measurement; Its two, be subjected to the influence of Animal behaviour and Measuring Time contradiction, certain difference often appears in experimental result; Its three, force animal in official hour, finish the work and therebetween force measure, can cause animal nervous system, endocrine and psychological stimulation, these harmful effect meetings change the effect of experiment, make experimental result produce deviation; Its four because these two kinds of methods can only experimentize to single animal,, thereby can not accurately calculate the motion merit of animal so different experiments can produce different results.
[summary of the invention]
The object of the present invention is to provide and a kind ofly can make testing result power measurement arrangement more accurately.
Further purpose of the present invention is to provide a kind of can realize the large sample zoopery, accurately the power measurement arrangement for animal movement of test animal motion merit.
The object of the present invention is achieved like this: this power measurement arrangement for animal movement comprises swiveling wheel, enumerator, photoelectric sensor and data processing equipment, this swiveling wheel has the fixed resistance square, the angular displacement signal of corresponding rotation wheel during photoelectric sensor induction animal movement, and converting this angular displacement signal to signal of telecommunication enter counter, data processing equipment receives the data of also handling the enumerator input.
Described swiveling wheel is provided with a pick off sum counter respectively for plural at least rotation wheels, each swiveling wheel, and data processing equipment receives and handle the data of each enumerator input.
Described photoelectric sensor is the grooved photo-coupler.
Described swiveling wheel comprises wheel hub, and the rod of climbing spaced apart is installed on this wheel hub, and this wheel hub rotational support is on a support by rotating shaft, this support is installed in feeds on the lid.
Described support comprises " L " type supporter, and rotating shaft is rotatable being installed on this supporter, and pick off is installed on this supporter and picks up and climb the signal of rod by this pick off when swiveling wheel rotates.
Compared with prior art, the present invention has following advantage: 1): by adopting photoelectric sensor, make enumerator not need directly to contact with swiveling wheel, thereby make animal institute work only be used to overcome the moment of resistance of swiveling wheel, thereby make testing result more accurate; 2) by rotation wheels, multisensor and enumerator are set, can realize the large sample measurement of power of animal is tested, make test result more accurate by data processing equipment.
[description of drawings]
Fig. 1 is the structural representation of wheel hub of the swiveling wheel of power measurement arrangement for animal movement of the present invention.
Fig. 2 is the axonometric chart of the swiveling wheel of power measurement arrangement for animal movement of the present invention.
Fig. 3 is the three-dimensional exploded view of power measurement arrangement for animal movement of the present invention.
Fig. 4 is the front view of power measurement arrangement for animal movement of the present invention.
Fig. 5 is a system architecture diagram of the present invention.
[specific embodiment]
See also Fig. 1 to Fig. 5, power measurement arrangement for animal movement of the present invention comprises rotation wheels and checkout gear.These rotation wheels comprise at least two independent swiveling wheels 1 that are provided with, each swiveling wheel 1 include the wheel hub 11 of two parallel interval settings and be arranged at therebetween climb the rod 12, this two wheel hub 11 couples together by the rod 12 of climbing that some equal angles distribute, and this distribution angle can be 360 °/32 or 360 °/48.Each swiveling wheel 1 turns to support by rotating shaft 2 and is installed on the support 3 of lattice-shaped, and this support 3 is mounted in the nursing lid 4 that is used to hold animal feed.This swiveling wheel 1 is that the supporter 31 by " L " type is installed on the support 3, and horizontal sides that should " L " type supporter 31 is fixedly mounted on the top of support 3, and its vertical edges is the setting of dangling downwards, and rotating shaft 2 is to be fixedly mounted on this vertical edges.
Checkout gear comprises pick off 5, enumerator and data processing equipment, and this pick off 5 and enumerator all have two at least.Each swiveling wheel 1 an all corresponding pick off 5 and enumerator, these pick off 5 sum counters connect, and each enumerator all is connected on the data processing equipment.The angular displacement motor message of swiveling wheel 1 when each pick off 5 picks up animal movement, this motor message of counter records, and this signal data is input to data processing equipment handles.Each pick off 5 is installed on the horizontal sides of supporter 31 at each self-corresponding swiveling wheel 1 top, in this implementation method, this pick off 5 is a photoelectric sensor 5, this photoelectric sensor 5 is the flute profile photo-coupler, it picks up the signal when respectively climbing rod 12 by the optical coupling slit when swiveling wheel 1 rotates, with its signal of go up jumping, and this signal is fed to its corresponding enumerator port by cable as count pulse.Each swiveling wheel 1 is to be arranged in successively on the feeder line support, the cable of each enumerator is connected with data processing equipment along this feeder line support, it connects employing computer general-purpose parallel cable and interface, thereby can support nearly 1-48 animal measurement of power experiment, each output all has identical structure, makes it efficiently be easy to administer and maintain.
This checkout gear also comprises input/output interface and control interface, and in the present embodiment, this enumerator is 18 digit counters, and this data processing equipment is single-chip microcomputer or central processing unit, and this input/output interface comprises display interface and printing interface.This checkout gear comprises single-chip microcomputer 89C55, the printing interface and the input/output interface that constitute by the 82C79 display interface, by the 81C55I/O interface, and two DLS12C887 clock chips.The output of this 18 bit data enumerator links to each other with the data/address bus of single-chip microcomputer 89C55, so that real-time the sending data to data processing equipment and finish corresponding date processing of recorded data.
The input of 18 digit counters is counting pulse signals that photoelectric sensor 5 sends, and each input pulse is measured as the least unit of metering merit, and the outfan of this enumerator is connected and receives at any time the reading command of this single-chip microcomputer with single-chip microcomputer 89C55.Control interface is connected with the control button, and printing interface is connected with printer, and display interface is connected with display.The external control of this checkout gear is to be used for I/O management, and it mainly comprises keyboard and function key dual mode.Keyboard management and print manager are arranged in the management procedure of data processing equipment, and the input of this keyboard, output are adopted the 82C79 chip, thereby can be sold to data handling procedure the running time of data processing equipment.In the ordinary course of things, this input, output can be managed by the function key on the keyboard, and the output of data comprises demonstration output and printout, and this demonstration output comprises 16 LED charactrons outputs and liquid crystal output, and this printout is that mini-printer is exported.
For satisfying the needs of large sample measuring as far as possible, nearly 48 such enumerators are arranged, in this device to support the nearly zoopery of 48 samples simultaneously.Do like this and not only can reduce the cost that experimental period also can reduce equipment to greatest extent.
The swiveling wheel of this device is an existing swiveling wheel with fixed resistance square, the animal (as mouse) that need carry out measurement of power during experiment moves in swiveling wheel, animal movement overcomes the moment of resistance acting of swiveling wheel, the rotational displacement of swiveling wheel can calculate animal movement institute work by the fixed resistance square of total angular displacement and swiveling wheel during by the metering animal movement.
For realizing that to zooperal centralized management 48 measurement of powers partly link together to utilize a data blood processor management counting to make nearly, carry out unified management.Reach an equipment summation and managed the purpose that multichannel is tested, the multichannel experiment utilizes a cover Single Chip Microcomputer (SCM) system, effectively raised the ratio of performance to price of equipment, made it to become a kind of cheap common apparatus.
For making this device obtain animal movement did work accurately " numerical value ", it is a fixed value that this device makes the rotational resistance torque of swiveling wheel with existing processing technology, enables to utilize more accurately angular displacement time of reflecting animal movement institute's work
During measuring, utilize the angular displacement of sensor swiveling wheel revolution moving 360 °/32 or 360 °/48 as a measurement unit metering animal movement process.Sensing data is counted by enumerator, finally provides the angular displacement that animal is finished in the stipulated time, and the merit of being finished with how many expressions of angular displacement.
This device can be measured nearly " numerical value " of 48 animal movement merits simultaneously, and set arbitrarily writing time in 0 to 24 hour, also can be set at the circulation mode determination.Digital display mode and printer output are adopted in reading of result.The data monitoring of its process has integral point to read, random time is read and read all day, also can select other output forms as required.

Claims (10)

1. power measurement arrangement for animal movement, comprise the swiveling wheel sum counter, this swiveling wheel has the fixed resistance square, it is characterized in that: also comprise photoelectric sensor and data processing equipment, the angular displacement signal of corresponding rotation wheel during photoelectric sensor induction animal movement, and converting this angular displacement signal to signal of telecommunication enter counter, data processing equipment receives the data of also handling the enumerator input.
2. power measurement arrangement for animal movement as claimed in claim 1, it is characterized in that: described swiveling wheel is plural at least rotation wheels, each swiveling wheel is provided with a pick off sum counter respectively, and data processing equipment receives and handle the data of each enumerator input.
3. power measurement arrangement for animal movement as claimed in claim 2 is characterized in that: described photoelectric sensor is the flute profile photo-coupler.
4. as any described power measurement arrangement for animal movement of claim 1-3, it is characterized in that: described swiveling wheel comprises wheel hub, the rod of climbing spaced apart is installed on this wheel hub, and this wheel hub rotational support is on a support by rotating shaft, this support is installed in feeds on the lid.
5. power measurement arrangement for animal movement as claimed in claim 4 is characterized in that: the described rod of climbing is that equal angles is distributed on the wheel hub.
6. power measurement arrangement for animal movement as claimed in claim 5 is characterized in that: described distribution angle is 360 °/32 or 360 °/48.
7. power measurement arrangement for animal movement as claimed in claim 4, it is characterized in that: described support comprises " L " type supporter, rotating shaft is rotatable being installed on this supporter, and pick off is installed on this supporter and picks up and climb the signal of rod by this pick off when swiveling wheel rotates.
8. as any described power measurement arrangement for animal movement of claim 1-3, it is characterized in that: described data processing equipment is a single-chip microcomputer.
9. power measurement arrangement for animal movement as claimed in claim 8 is characterized in that: also comprise the display interface, printing interface and the clock chip that are connected with data processing equipment, another termination display of this display interface, another termination printer of this printing interface.
10. power measurement arrangement for animal movement as claimed in claim 9 is characterized in that: described single-chip microcomputer model is 89C55, and display interface is 82C79, and printing interface is 81C55, and clock chip is DLS12C887.
CNB2004101551101A 2004-05-25 2004-05-25 Power measurement arrangement for animal movement Expired - Fee Related CN100434033C (en)

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8416102B2 (en) * 2008-03-14 2013-04-09 Koninklijke Philips Electronics N.V. Activity monitoring system insensitive to accelerations induced by external motion factors
CN101810516B (en) * 2010-04-07 2011-06-22 中国航天员科研训练中心 Rat swing experiment table
CN104665759A (en) * 2015-03-26 2015-06-03 河南中医学院 Animal visual function determinator
CN111345824B (en) * 2020-04-28 2020-08-11 苏州大学 Rotating rod fatigue testing device and testing method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423630A (en) * 1981-06-19 1984-01-03 Morrison Thomas R Cyclic power monitor
US5081991A (en) * 1989-03-14 1992-01-21 Performance Predictions, Inc. Methods and apparatus for using nuclear magnetic resonance to evaluate the muscle efficiency and maximum power of a subject during locomotion
DE4213065A1 (en) * 1992-04-21 1993-10-28 Norbert H L Dr Ing Koster Self-identifying physical or physiological telemetering system - includes implanted double-resonant transponder switched to receive strong power supply signal and transmit weaker measurement signal in turn
JP2002250740A (en) * 2001-02-23 2002-09-06 Nec Tokin Ceramics Corp Momentum-measuring device
US20030114769A1 (en) * 1999-08-20 2003-06-19 Capital Tool Company Limited Microminiature radiotelemetrically operated sensors for small animal research
CN2827267Y (en) * 2004-05-25 2006-10-18 一泰医药研究(深圳)有限公司 Device for testing power dissipation of kinesic animals

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423630A (en) * 1981-06-19 1984-01-03 Morrison Thomas R Cyclic power monitor
US5081991A (en) * 1989-03-14 1992-01-21 Performance Predictions, Inc. Methods and apparatus for using nuclear magnetic resonance to evaluate the muscle efficiency and maximum power of a subject during locomotion
DE4213065A1 (en) * 1992-04-21 1993-10-28 Norbert H L Dr Ing Koster Self-identifying physical or physiological telemetering system - includes implanted double-resonant transponder switched to receive strong power supply signal and transmit weaker measurement signal in turn
US20030114769A1 (en) * 1999-08-20 2003-06-19 Capital Tool Company Limited Microminiature radiotelemetrically operated sensors for small animal research
JP2002250740A (en) * 2001-02-23 2002-09-06 Nec Tokin Ceramics Corp Momentum-measuring device
CN2827267Y (en) * 2004-05-25 2006-10-18 一泰医药研究(深圳)有限公司 Device for testing power dissipation of kinesic animals

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