CN100368263C - Production of multiple chamber-bags for large infusion for preventing from opening pollution at charging after sterilization - Google Patents
Production of multiple chamber-bags for large infusion for preventing from opening pollution at charging after sterilization Download PDFInfo
- Publication number
- CN100368263C CN100368263C CNB200610031294XA CN200610031294A CN100368263C CN 100368263 C CN100368263 C CN 100368263C CN B200610031294X A CNB200610031294X A CN B200610031294XA CN 200610031294 A CN200610031294 A CN 200610031294A CN 100368263 C CN100368263 C CN 100368263C
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- Prior art keywords
- bag
- medicine
- chamber
- infusion solutions
- seal
- Prior art date
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 63
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 44
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 15
- 238000001802 infusion Methods 0.000 title description 6
- 239000003814 drug Substances 0.000 claims abstract description 79
- 239000003978 infusion fluid Substances 0.000 claims abstract description 53
- 229940126589 solid medicine Drugs 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000003466 welding Methods 0.000 claims abstract description 16
- 230000001681 protective effect Effects 0.000 claims description 41
- 238000007689 inspection Methods 0.000 claims description 22
- 238000010926 purge Methods 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 abstract description 10
- 238000007789 sealing Methods 0.000 abstract description 10
- 238000005516 engineering process Methods 0.000 abstract description 8
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000000843 powder Substances 0.000 description 24
- 230000010412 perfusion Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 238000012856 packing Methods 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The present invention discloses a method for manufacturing a non-PVC film multi-chamber bag for infusion solutions, which can prevent medicine feeding joints from being polluted and prevent residual water leaving in the medicine feeding joints after sterilization. The present invention aims to provide a non-PVC film multi-chamber bag for infusion solutions with simple manufacturing technology, which can prevent sterilizing media, etc. from entering medicine feeding chambers of the medicine feeding joints at the time of sterilization, so that the medicine feeding chambers are free from pollution and has no residual water after sterilization. The present invention comprises the technical steps: making bags, filling medicine for infusion solutions and sealing, coating a protecting bag outside the multi-chamber bag, sterilizing the multi-chamber bag in high temperature, removing the protecting bag, filling solid medicine, and sealing and welding labels. The present invention is characterized in that the present invention also comprises the technical steps: coating the protecting bag outside the multi-chamber bag after filling medicine for infusion solutions and before sterilizing the multi-chamber bag in high temperature, and removing the protecting bag after sterilizing the multi-chamber bag in high temperature and before filling the solid medicine and sealing.
Description
Technical field
The invention belongs to the medical packaging field, be specifically related to that a kind of powder charge chamber that solves medicine filling mouthpiece after sterilizing is avoided polluting and the production method of the non-PVC film multi-chamber-bag infusion solutions of noresidue water.
Background technology
It has only a charging room existing single port pipe single chamber infusion solutions bag, and can only adorn a kind of soup.Earlier make the single chamber bag during production by Bag Making Machine, pour in the bag again medicine with the combination cover welding.Because infusion solutions is generally normal saline or nutrient solution, with can not long-term storage after the therapeutic solid medicine mixes, thereby have only in use and the therapeutic solid medicine could be mixed with infusion solutions, its process is: extract the soup in the infusion bag out inject the dress solid medicine container with syringe earlier, extract the bag that injects the dress infusion solutions after it is dissolved fully again out from the container of dress solid medicine.In the man-hour that the infusion bag of this packing must also will be wasted a disposable syringe and make up a prescription in use, increase use cost; When first aid, delay rescue time, may cause serious consequence; Concerning busy nurse, also easily cause the mismatch medicine may, whether or it is correct not know to make up a prescription during transfusion after making up a prescription etc.For solving the problems of the technologies described above, can on same infusion bag, be provided with a plurality of can be with the charging room of fashionable dress liquid medicine and solid medicine, promptly make the non-PVC membrane big transfusion multi-chamber bag, but the medicine filling mouthpiece that can on Bag for holding medicine, connect powder charge in its inner chamber, dress large transfusion fluid medicine in the Bag for holding medicine, dress solid medicine or liquid medicine in the medicine filling mouthpiece.Liquid medicine palpus high-temperature sterilization behind filling and sealing in the infusion solutions, and solid medicine (mainly referring to aseptic powder) can not at high temperature be sterilized, i.e. solid medicine can is carried out after must being placed on the sterilization of liquid medicine.Because the powder charge chamber of medicine filling mouthpiece is an opening when sterilization, in sterilization process, thereby the powder charge chamber is vulnerable to pollute the requirement that can't satisfy sterile powder class drug package.After sterile medium of using when sterilizing simultaneously such as water or water vapour entered the powder charge chamber, essential oven dry could the package powder.
Summary of the invention
Technical matters to be solved by this invention is the defective that overcomes above-mentioned prior art, provide a kind of prevent when sterilization sterile medium etc. enter the powder charge chamber of medicine filling mouthpiece, make the powder charge chamber avoid polluting and noresidue water after sterilization, technology is simply avoided sterilizing, and the back medicine filling mouthpiece pollutes and the non-PVC film multi-chamber-bag infusion solutions production method of noresidue water.
For solving the problems of the technologies described above, the present invention adopts following technical proposals.
The non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of a kind of back medicine filling mouthpiece of avoiding sterilizing; its processing step comprise bag, the can of infusion solutions medicine and seal, high-temperature sterilization, solid medicine can and seal with label and weld; it is characterized in that described processing step also comprises: infusion solutions medicine can and seal the back, outside multi-chamber-bag, coat protective bag before the high-temperature sterilization, behind high-temperature sterilization, the solid medicine can and seal before remove protective bag.
Described protective bag by clean (satisfying the hygienic requirements of the I class cartridge bag material of national regulation) but high-temperature sterilization and the complex film that meets I class cartridge bag material with high water proof vapour are made.
Described high-temperature sterilizing process is a general-duty big infusion soft bag sterilization process.
Concrete processing step of the present invention can comprise: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, dry, remove protective bag, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
Concrete processing step of the present invention also can comprise: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, remove protective bag, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
Concrete processing step of the present invention also can comprise: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, dry, remove protective bag, lamp inspection, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
Concrete processing step of the present invention can comprise again: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, remove protective bag, lamp inspection, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
Beneficial effect of the present invention is: this time be vulnerable to the pollution of medicine behind quick-fried bag adorned in sterile medium and the infusion solutions bag when the high-temperature sterilization at the powder charge chamber of the medicine filling mouthpiece that links to each other with the infusion solutions bag in the multi-chamber-bag; the protective bag made from complex film high temperature resistant and high resistant steam before sterilization seals multi-chamber-bag, prevent when sterilization sterile medium etc. enter the powder charge chamber of medicine filling mouthpiece.The powder charge chamber is avoided polluting and noresidue water after sterilization, the health rank (satisfy the hygienic requirements of the I class cartridge bag material of national regulation) of powder charge chamber after sterilization that guarantees medicine filling mouthpiece with sterilize before identical, to satisfy the packing requirements of sterile powder class medicine.
Description of drawings
Fig. 1 is the structural representation after bag technology of the present invention is finished;
Fig. 2 is the structural representation after infusion solutions medicine of the present invention can and sealing process are finished;
Fig. 3 is that multi-chamber-bag of the present invention coats the structural representation after protective bag technology is finished outward;
Fig. 4 is the cutaway view of Fig. 3;
Fig. 5 is the structural representation after solid medicine can of the present invention and sealing process are finished;
Fig. 6 is the structural representation after label welding process of the present invention is finished;
Fig. 7 is the structural representation after bag technology is finished outside the bag of the present invention.
Each label is represented among the figure:
1, medicine filling mouthpiece 11, powder charge chamber
12, perfusion passage 13, easy-to-fold cap
14, Connection Block
2, infusion solutions bag 3, label
4, seal cover cap 5, combination cover
6, protective bag 7, outer bag
The specific embodiment
Below in conjunction with accompanying drawing, the invention will be further described.
Embodiment 1: production method of the present invention, its processing step is followed successively by: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, remove protective bag, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
1) bag: at first produce bag as shown in Figure 1, in this bag, infusion solutions bag 2 is welded to connect with medicine filling mouthpiece 1, medicine filling mouthpiece 1 is by the powder charge chamber 11 that is set up in parallel, perfusion passage 12 is formed an integral structure with the Connection Block 14 that is connected powder charge chamber 11 and perfusion passage 12, the bottom in powder charge chamber 11 is provided with the easy-to-fold cap 13 that communicates with the inner chamber of infusion solutions bag 2, this easy-to-fold cap 13 places the inner chamber of infusion solutions bag 2 (easy-to-fold cap 13 to be fractureed, then the inner chamber in powder charge chamber 11 communicates with the inner chamber of infusion solutions bag 2, and infusion solutions medicine in the infusion solutions bag 2 and the powder medicine in the powder charge chamber 11 can mix);
2) infusion solutions medicine can and sealing: as shown in Figure 2, with infusion solutions by perfusion passage 12 pour into infusion solutions bag 2 backs by seal cover cap 4 with 12 sealings of the perfusion passage in the medicine filling mouthpiece 1;
3) multi-chamber-bag coats protective bag outward: again bag shown in Figure 2 is sealed in clean (satisfying the hygienic requirements of the I class cartridge bag material of national regulation) but high-temperature sterilization and having in the protective bag 6 that the complex film that meets I class cartridge bag material of high water proof vapour makes, shown in Fig. 3,4.
4) high-temperature sterilization: with bag high-temperature sterilization shown in Figure 3.
5) remove protective bag: protective bag 6 is cut off.
6) medicine filling mouthpiece air purge oven dry: medicine filling mouthpiece 1 usefulness the ion wind purge on the bag of infusion solutions will be housed and dry.
7) solid medicine can and sealing: pour into powder medicine in the powder charge chamber 11 and as shown in Figure 5 with combination cover 5 sealings.
8) lamp inspection: bag shown in Figure 5 is carried out the lamp inspection.
9) label welding: after the lamp inspection is qualified, label 3 is welded in infusion solutions bag 2 one sides, as shown in Figure 6, it in this example the bottom side that is welded in infusion solutions bag 2, have label substance 31 on the label 3, the suppending hole of being convenient to hang when using 32 also can be set on label 3, and medicine filling mouthpiece is contaminated after then can avoiding sterilizing completes substantially with non-PVC film multi-chamber-bag infusion solutions residuary water.
10) outer bag: will be as shown in Figure 6 bag wrap antisoiling outer bag 7 again, as shown in Figure 7, contaminated and non-PVC film multi-chamber-bag infusion solutions residuary water of the back medicine filling mouthpiece of then can avoiding sterilizing completes.
Embodiment 2: the concrete processing step of present embodiment is followed successively by: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, dry, remove protective bag, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
The present embodiment difference from Example 1 is: step 4) high-temperature sterilization and step 5) at embodiment 1 are removed between the protective bag, are provided with a baking step, can with through behind the high-temperature sterilization as shown in Figure 4 the bag on residuary water Tumble Dry.
Embodiment 3: the concrete processing step of present embodiment is followed successively by: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, remove protective bag, lamp inspection, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
The present embodiment difference from Example 1 is: remove protective bag and 6 in the step 5) of embodiment 1) between the medicine filling mouthpiece air purge oven dry, also be provided with lamp inspection step.
Embodiment 4: the concrete processing step of present embodiment is followed successively by: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, dry, remove protective bag, lamp inspection, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
The present embodiment difference from Example 1 is: step 4) high-temperature sterilization and step 5) at embodiment 1 are removed between the protective bag; be provided with a baking step; can with through behind the high-temperature sterilization as shown in Figure 4 the residuary water on the bag Tumble Dry: remove protective bag and 6 in the step 5) of embodiment 1) between the medicine filling mouthpiece air purge oven dry, also be provided with a lamp and examine step.
High-temperature sterilizing process in the various embodiments described above is a general-duty big infusion soft bag sterilization process.
Claims (6)
1. the non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of the back medicine filling mouthpiece of can avoiding sterilizing; its processing step comprise bag, the can of infusion solutions medicine and seal, high-temperature sterilization, solid medicine can and seal with label and weld; it is characterized in that described processing step also comprises: infusion solutions medicine can and seal the back, outside multi-chamber-bag, coat protective bag before the high-temperature sterilization, behind high-temperature sterilization, the solid medicine can and seal before remove protective bag.
2. the non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of the back medicine filling mouthpiece of avoiding sterilizing according to claim 1, but it is characterized in that described protective bag made by high-temperature sterilization and the complex film that meets I class cartridge bag material with high water proof vapour.
3. the non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of the back medicine filling mouthpiece of avoiding sterilizing according to claim 1 and 2 is characterized in that its concrete processing step comprises: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, dry, remove protective bag, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
4. the non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of the back medicine filling mouthpiece of avoiding sterilizing according to claim 1 and 2 is characterized in that its concrete processing step comprises: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, remove protective bag, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
5. the non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of the back medicine filling mouthpiece of avoiding sterilizing according to claim 1 and 2 is characterized in that its concrete processing step comprises: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, dry, remove protective bag, lamp inspection, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
6. the non-PVC film multi-chamber-bag infusion solutions production method of the contaminated and residuary water of the back medicine filling mouthpiece of avoiding sterilizing according to claim 1 and 2 is characterized in that its concrete processing step comprises: bag, the can of infusion solutions medicine and seal, multi-chamber-bag coats protective bag, high-temperature sterilization outward, remove protective bag, lamp inspection, the oven dry of medicine filling mouthpiece air purge, solid medicine can and seal, lamp inspection, label welding and the outer bag of bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610031294XA CN100368263C (en) | 2006-03-03 | 2006-03-03 | Production of multiple chamber-bags for large infusion for preventing from opening pollution at charging after sterilization |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610031294XA CN100368263C (en) | 2006-03-03 | 2006-03-03 | Production of multiple chamber-bags for large infusion for preventing from opening pollution at charging after sterilization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1817747A CN1817747A (en) | 2006-08-16 |
| CN100368263C true CN100368263C (en) | 2008-02-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610031294XA Expired - Fee Related CN100368263C (en) | 2006-03-03 | 2006-03-03 | Production of multiple chamber-bags for large infusion for preventing from opening pollution at charging after sterilization |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101792028A (en) * | 2010-02-26 | 2010-08-04 | 四川沱牌药业有限责任公司 | Application of double-layer aseptic technique in outer package of large capacity injection |
| CN102247287B (en) * | 2010-05-20 | 2013-05-15 | 石家庄四药有限公司 | Making and sterilizing method of polypropylene plastic infusion bottle |
| JP5847180B2 (en) * | 2010-08-27 | 2016-01-20 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Packaging system for multi-component medical products |
| JP2017024727A (en) * | 2015-07-16 | 2017-02-02 | 日立造船株式会社 | Hermetically sealed bag, hermetically sealed package, aseptic charging system and method for manufacturing hermetically sealed package |
| CN113071735A (en) * | 2021-04-27 | 2021-07-06 | 汕头市达能轻工机械有限公司 | Multi-placenta packaging finished product of sauce and solid granular food and production method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001087350A (en) * | 1999-07-22 | 2001-04-03 | Showa Denko Kk | Multi-chamber transfunction container and method of manufacturing the same |
| JP2001314484A (en) * | 2000-05-08 | 2001-11-13 | Hideki Munekuni | Medical plural chamber container and manufacturing method thereof |
| US20020099354A1 (en) * | 2001-01-24 | 2002-07-25 | Carmel Pharma Ab | Infusion bag and infusion system |
| JP2003191405A (en) * | 2001-12-28 | 2003-07-08 | Fujimori Kogyo Co Ltd | Plastic film for medical liquid container |
| CN2686600Y (en) * | 2004-03-18 | 2005-03-23 | 湖南千山制药机械股份有限公司 | Double-chamber bag for trans fusion |
| CN1642716A (en) * | 2002-03-28 | 2005-07-20 | 昭和电工塑料产品株式会社 | Infusion container with multiple chambers and production method thereof |
-
2006
- 2006-03-03 CN CNB200610031294XA patent/CN100368263C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001087350A (en) * | 1999-07-22 | 2001-04-03 | Showa Denko Kk | Multi-chamber transfunction container and method of manufacturing the same |
| JP2001314484A (en) * | 2000-05-08 | 2001-11-13 | Hideki Munekuni | Medical plural chamber container and manufacturing method thereof |
| US20020099354A1 (en) * | 2001-01-24 | 2002-07-25 | Carmel Pharma Ab | Infusion bag and infusion system |
| JP2003191405A (en) * | 2001-12-28 | 2003-07-08 | Fujimori Kogyo Co Ltd | Plastic film for medical liquid container |
| CN1642716A (en) * | 2002-03-28 | 2005-07-20 | 昭和电工塑料产品株式会社 | Infusion container with multiple chambers and production method thereof |
| CN2686600Y (en) * | 2004-03-18 | 2005-03-23 | 湖南千山制药机械股份有限公司 | Double-chamber bag for trans fusion |
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| CN1817747A (en) | 2006-08-16 |
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