CL2017002677A1 - Method to increase the percentage of monomeric fab-dsfv antibodies of multimeric species - Google Patents

Method to increase the percentage of monomeric fab-dsfv antibodies of multimeric species

Info

Publication number
CL2017002677A1
CL2017002677A1 CL2017002677A CL2017002677A CL2017002677A1 CL 2017002677 A1 CL2017002677 A1 CL 2017002677A1 CL 2017002677 A CL2017002677 A CL 2017002677A CL 2017002677 A CL2017002677 A CL 2017002677A CL 2017002677 A1 CL2017002677 A1 CL 2017002677A1
Authority
CL
Chile
Prior art keywords
percentage
increase
multimeric species
monomeric fab
species
Prior art date
Application number
CL2017002677A
Other languages
Spanish (es)
Inventor
Sam Philip Heywood
Gavin Barry Wild
Razwan Hanif
Page Christopher John Le
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of CL2017002677A1 publication Critical patent/CL2017002677A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN PROPORCIONA UN MÉTODO PARA AUMENTAR EL PORCENTAJE DE MONÓMERO EN UNA COMPOSICIÓN DE MOLÉCULAS DE ANTICUERPO EXPRESADAS RECOMBINAITEMENTE QUE SE CARACTERIZAN PORQUE LA MOLÉCULA DE ANTICUERPO COMPRENDE AL MENOS UN EV CON ESPECIFICIDAD PARA UN ANTÍGENO DE INTERÉS QUE COMPRENDE UNA VH Y UNA VL EN LA QUE DICHOS VH Y VL ESTÁN CONECTADOS DIRECTA O INDIRECTAMENTE A TRAVÉS DE UNO O MÁS ENLACES Y SE ESTABILIZAN MEDIANTE UN ENLACE DISULFURO ENTRE ELLOS, DICHO MÉTODO COMPRENDE: A) UNA ETAPA DE CONVERSIÓN TÉRMICA DE MANTENER LA COMPOSICIÓN QUE COMPRENDE LA MOLÉCULA DE ANTICUERPO A UNA TEMPERATURA EN EL INTERVALO DE 30 A 60 C DURANTE UN PERÍODO DE AL MENOS 1 HORA, EN EL QUE LA ETAPA A) SE REALIZA EN LA PRESENCIA DE UN AGENTE REDUCTOR O DESPUÉS DEL TRATAMIENTO CON UN AGENTE REDUCTOR.</p><p> THE PRESENT INVENTION PROVIDES A METHOD FOR INCREASING THE PERCENTAGE OF MONOMER IN A COMPOSITION OF RECOMBINATELY EXHIBITED MOLECULES THAT ARE CHARACTERIZED BECAUSE THE ANTIBODY MOLECULE UNDERTAKES AT LEAST ONE EVENT FOR A SPECIES VL IN WHICH SUCH VH AND VL ARE DIRECTLY OR INDIRECTLY CONNECTED THROUGH ONE OR MORE LINKS AND STABILIZE THROUGH A DIFFERENT LINK BETWEEN THEM, SUCH METHOD OF CONVERSION THROUGH THE MERCHANGE COMPARTMENT OF THE COMMERCE ANTIBODY TO A TEMPERATURE IN THE INTERVAL FROM 30 TO 60 C FOR A PERIOD OF AT LEAST 1 HOUR, IN WHICH STAGE A) IS PERFORMED IN THE PRESENCE OF A REDUCING AGENT OR AFTER TREATMENT WITH A REDUCING AGENT. </p>

CL2017002677A 2015-04-22 2017-10-20 Method to increase the percentage of monomeric fab-dsfv antibodies of multimeric species CL2017002677A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1506869.5A GB201506869D0 (en) 2015-04-22 2015-04-22 Method

Publications (1)

Publication Number Publication Date
CL2017002677A1 true CL2017002677A1 (en) 2018-03-23

Family

ID=53299018

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017002677A CL2017002677A1 (en) 2015-04-22 2017-10-20 Method to increase the percentage of monomeric fab-dsfv antibodies of multimeric species

Country Status (16)

Country Link
US (2) US10829565B2 (en)
EP (1) EP3286220A1 (en)
JP (1) JP6901402B2 (en)
KR (1) KR20170138551A (en)
CN (1) CN107683290B (en)
AU (1) AU2016251960A1 (en)
BR (1) BR112017022472A2 (en)
CA (1) CA2983537A1 (en)
CL (1) CL2017002677A1 (en)
CO (1) CO2017010845A2 (en)
EA (1) EA201792325A1 (en)
GB (1) GB201506869D0 (en)
IL (1) IL255094A0 (en)
MX (1) MX2017013419A (en)
SG (1) SG11201708430VA (en)
WO (1) WO2016170137A1 (en)

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GB201506868D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
GB201506869D0 (en) * 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
CN110392695B (en) * 2016-12-09 2021-02-02 Ose免疫疗法 Antibodies and polypeptides against CD127

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Also Published As

Publication number Publication date
CO2017010845A2 (en) 2018-03-20
KR20170138551A (en) 2017-12-15
US20210079120A1 (en) 2021-03-18
US20180142039A1 (en) 2018-05-24
IL255094A0 (en) 2017-12-31
SG11201708430VA (en) 2017-11-29
EP3286220A1 (en) 2018-02-28
WO2016170137A1 (en) 2016-10-27
CN107683290B (en) 2022-01-04
JP2018515453A (en) 2018-06-14
EA201792325A1 (en) 2018-04-30
JP6901402B2 (en) 2021-07-14
AU2016251960A1 (en) 2017-11-02
CA2983537A1 (en) 2016-10-27
CN107683290A (en) 2018-02-09
US11834514B2 (en) 2023-12-05
MX2017013419A (en) 2018-02-09
US10829565B2 (en) 2020-11-10
BR112017022472A2 (en) 2018-07-17
GB201506869D0 (en) 2015-06-03

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