CH718051A1 - System for processing patient health indicator values. - Google Patents

Abstract

A system for processing health indicator values to determine a numerical score representative of the general health of a patient, comprises a database (1) comprising a series of indicator values of different health aspects calibrated according to standardized values. Several input means (2A, 2B, 2C) are each associated with at least one patient. As many intermediate servers (7) are each associated with the input means (2A, 2B, 2C) of one or more patients, and communicate with a master server (8) comprising a calculation unit (4) for the whole intermediate servers. Raw data of indicators of different health aspects of a patient received by the input means (2A, 2B, 2C) are calibrated and transmitted to the master server (8) whose calculated score is stored in a display (5) for example a smartphone associated with the patient input means.

Description

[0001] The subject of the present invention is a system for processing values of health indicators of at least one patient to determine for each patient a numerical score representative of the general health of the patient in order to help him find, optimize and maintain their health and ensure and increase their well-being and longevity.

[0002] The applicant's publication WO2016110734 has already disclosed a method for evaluating a score representative of a patient's health, based on the following considerations.

[0003] The immediate accessibility to the results of scientific research allows a phenomenal acceleration of the understanding of human physiology. Despite this, patients are still too often treated according to incorrect or incomplete concepts. This method is based only on recent and validated research in order to offer patients optimal care.

[0004] Health is the result of the balance between two parts of the body, the gastrointestinal system or digestive brain and the nervous system or brain encephalon.

[0005] The digestive brain must supply energy, essential nutrients, vitamins and trace elements. It must also act as a protective barrier in the same way as the skin, the pulmonary mucosa and the blood-brain barrier, in order to prevent the entry of unwanted intruders. It constantly communicates with the brain through the enteric nervous system and through numerous hormones, lipoproteins, interleukins and other substances, some of which are still unknown.

[0006] The digestive interface is to be designed as a whole. The thousands of species of bacteria that are contained in the digestive tract of an individual are part of it. They have lived in symbiosis with generations of individuals for thousands of years. Each individual feeds on the fruits of his metabolisms. They provide about 50% of the essential nutrient intake for each individual. They also produce a lot of lipoproteins, which are able to send information to the brain. They play a fundamental role in immune functions and especially in the production of inflammation, which can affect the whole body. The latest scientific evidence clearly demonstrates the links between the intestinal flora and certain diseases, such as obesity or type 2 diabetes. It is therefore essential to ensure the quality of an individual's intestinal flora in order to preserve their health.

[0007] The intestinal mucosa for its part plays a real role as a barrier. It is made up of juxtaposed cells that are held together by tight junctions. The integrity of these links is essential. The intestinal mucosa is the boundary between the outside and the inside of the body. It is therefore not surprising that more than half of an individual's immune defenses are located along his digestive tract. When a bacterium or a foreign protein penetrates this protective layer, the immune system must take over to rid the individual of it. This can represent considerable energy expenditure for the body. This energy will no longer be available for other functions. It is therefore essential to ensure that the intestinal cells (enterocytes) receive optimal nutrition and that nothing attacks the tight junctions.

[0008] The brain encephalon is the motor, the regulator, the coordinator of all the essential functions. For this brain to function well, it must firstly be well protected by the digestive brain and secondly be permanently activated. Physical activity, movement via the stimulation of neurons in the cerebellum, is the most important activation. Other visual, auditory, gustatory and tactile stimuli also play this role.

[0009] During evolution, the brain has changed. It is possible to distinguish different zones according to the stages of development. The primitive brain, known as the nervous or reptilian system, is the most important area with regard to health. It manages the essential functions and ensures the proper coordination of the different cycles punctuating the days of an individual. The other areas have regulatory actions on the reptilian brain.

[0010] The evaluation of the functioning of all these zones is therefore essential if the individual wants to know his state of health. It is done thanks to new discoveries made in the field of functional neurology. It is therefore possible to stimulate or inhibit certain brain areas in order to modify their regulatory effects on the nervous system.

[0011] Moreover, the marker of cellular suffering is well known. This is oxidative stress.

[0012] Furthermore, doctors, like patients, are less and less available and if finding an appointment in the event of illness is still manageable, scheduling appointments for medical follow-up is increasingly complicated.

[0013] Today an individual has on the one hand applications on smartphones for example to monitor his sports performance, to monitor his nights sleep, and on the other hand a medical file with each of the doctors he consults.

[0014] The object of the present invention is to provide a system for processing values of health indicators of at least one patient to determine for each patient a numerical score representative of the general health of the patient in order to help him to regain, optimize and maintain one's health and to ensure and increase one's well-being and longevity.

The invention relates to a system for processing values of health indicators of at least one patient to determine for each patient a numerical score representative of the general health of the patient. The system comprises a database comprising a series of values of health indicators calibrated according to standardized values, means for inputting a series of data of health indicators of a patient from among said standardized values, a unit for storing data received by the input means and a unit for calculating a numerical score representative of the general health of a patient according to a weighting of the values of health indicators of a patient.

[0016] Such a system stems from the implementation of the method described in WO2016110734 by a generalization of the values of health indicators and their groupings as well as by the weighting applied, whereas the method of WO2016110734 which will be described later involves values of health indicators and their groupings defined and a particular weighting.

An object of the present invention is to provide such a system which can implement the method of WO2016110734 in an easier way for the calculation of the health score and in particular by making the accessibility of the score faster at each patient, which is particularly advantageous when the system treats a large number of patients.

Another object of the invention is to provide such a system which can implement other methods with other values of health indicators and according to other weightings of the health indicator values of a patient. .

[0019] According to the invention, said input means comprise an electronic sensing device comprising at least one sensor arranged to receive raw health indicator data from a patient and to calibrate these raw data according to the standardized values from the database. There is a plurality of said input means each associated with at least one patient, and each of said input means is associated with its own intermediate server comprising a storage unit receiving input means associated therewith by means of communication the data calibrated according to the standardized values of the database. The calculation unit is integrated in a master server receiving by a means of communication, from each intermediate server, the data calibrated according to the standardized values of the database. Each intermediate server constitutes with the master server a platform for exchanging data of health scores calculated by the calculation unit of the master server, this data exchange platform being configured to store the general health score of each patient at a location associated with said patient-specific input means. The unit for calculating a numerical score representative of the general health of a patient is arranged to calculate the health score of a patient instantaneously each time data from a value of a health indicator influencing said health score, so that the general health score of each patient stored in the data exchange platform associated with said specific input means for the patient is automatically updated.

[0020] WO2016110734 on behalf of the applicant defines its method for determining a numerical score representative of the general health of a patient according to a series of indicators linked to the general state of health of the patient and stored in a database, which method can be implemented by the system of the present invention. This method comprises the following steps: – in an initial calibration step, a database is established from a series of indicators linked to the general state of health of the patient comprising indicators relating to oxidative stress, indicators relating to the functions of the digestive brain, indicators relating to the functions of the reptilian brain and indicators relating to the physical abilities of the patient coupled with his information on his general state of health, each individual indicator being assigned a numerical value between 0 and 10, and then - a statistical analysis of this database is carried out in order - to establish for each of said indicators of a patient a score, between 0 and 10, according to a measured value of the indicators of the state of health of the patient in relation to reference values, – establishing four groups made up of said indicators stored in the database, i.e.: • a group of indicators s relating to oxidative stress, hereinafter Group 1; • a group of indicators relating to the functions of the digestive brain, hereinafter Group 2; • a group of indicators relating to the functions of the reptilian brain, hereinafter Group 3; and • a group of indicators relating to the physical aptitudes of the patient coupled with his information on his general state of health, hereinafter Group 4, and – a value is attributed, for the patient, to each group ranging between 0 and 100, according to the scores of the patient's indicators, the value of each group being determined by the relationship 10*(the sum of the scores from 0 to 10 of each of a number N of indicators of the group of indicators taken into consideration for the calculation of the value of each group) / N, – then a health score S specific to the general health of the patient is calculated, on a scale between 0 and 100, using the formula: S = (Σ 1 *(Value Group 1) + 2*(Value Group 2) + 2*(Value Group 3) + 3*(Value Group 4)) / 8.

The numerical score is determined on a scale of 0 to 100. The value of each group also varies from 0 to 100 while the value of each indicator varies from 0 to 10.

[0022] In a preferred embodiment of this method, the Group 1 value is determined using scores linked to a digestive analysis, an oxidized LDL (Low Density Lipoprotein) value, a HOMA (homoestasis model assessment), a Selenium value, a Ferritin value, and a Zinc value. Group 1 gives a value to oxidative stress.

[0023] Oxidative stress is the basis of many chronic diseases and is the result of very reactive molecules, linked to oxygen, damaging our most vital molecules at all times, eventually making us sick. The paradox is that these very reactive molecules, called free radicals, have important biological functions, intervening in particular in cell signaling and are useful for the individual. In excess, they can also attack all the constituents of life and promote chronic diseases such as cataracts, cancer, coronary heart disease, diabetes, kidney failure, Alzheimer's, Parkinson's... In theory, these free radicals are neutralized or supported by the body's protective mechanisms called antioxidants. Antioxidants appear today as the keys to longevity and our allies in the fight against modern diseases. These are protective elements that intervene by trapping free radicals. Oxidative stress can generate temporary or persistent physical or nervous fatigue, as well as eating disorders.

In one embodiment of the method, the Group 2 value is determined using scores related to a digestive analysis, a CRP (C-reactive protein) value, a HOMA index and a ratio value. Omega 6/Omega 3. Group 2 gives a value for digestive inflammation.

[0025] In one embodiment of the method, the value of Group 3 is determined using scores linked to a health questionnaire, a value linked to the measurement of the perception time, a value of the homocysteine, a value of the Omega 3 index, a score linked to cardiac variability parameters during the night in particular, a value of the quadratic mean of the successive differences in heart rate, a value of the LF / HF ratio (low frequency / high frequency) reflecting the global sympathetic-vagal balance, a value of the recovery index during sleep, and a value related to measurements made on the total activity of the autonomic nervous system. Group 3 allows to give a value to the functioning of the brain.

[0026] In particular, the measurement of the activity of the nervous system is carried out through cardiac variability during the effort and over 24 hours, which makes it possible to measure the quality of sleep and the individual capacity to recover. This measurement is essential in patient follow-up. The more we advance in the program, the more it must improve.

[0027] In one embodiment of the method, the value of Group 4 is determined in particular using scores linked to a health questionnaire, the results of which are analyzed and weighted, to an exercise test in terms of speed or power, the measurement of cardiac amplitude, a score linked to a speed test and the value of the quadratic mean of the successive differences in heart rate equal to or less than 10, a somatosensory test, a visual test, a vestibular test, a ferritin value, a HOMA index, a Zinc value, a selenium value, a CRP value and an immunity questionnaire value. Group 4 gives a general health value. Indeed, a complete assessment, oriented on an in-depth functional neurology examination, makes it possible to determine the level of function of the nervous system as well as the ability to control the upper cortical areas. The individual functioning and the interaction of the three main sensory systems, namely peripheral, vestibular and ocular, are also tested. We also evaluate the adaptation of the motor system, the visual capacities when the head is in motion as well as the functional capacities of the joints of the lower limbs. Each indicator has values between 0 and 10.

For example, the value of Group 1 can be determined according to the following formula: Valuegroup1= Σ (((3*DigestiveanalysisValue)+(3*oxidized LDLValue)+2*(ZincValue+ SeleniumValue) + HOMAindexValue+ FerritinValue)*10)/ 12

The value of Group 2 can be determined according to the following formula: Valuegroup2= Σ (((5*CRPValue)+(3*DigestiveanalysisValue)+2*(Omega6/Omega3Value)+ HOMAindexValue)*10)/11

[0030] The value of group 3 can be determined according to the following formula: Group 3 value =Z((3* Health questionnaire value)+(4* Perception time measurement value)+(5* Autonomic nervous system measurement value)+(3* Cardiac variability parameter value during the night HF)+(3* Cardiac variability parameter value during the night LF )+(3* Mean quadratic value of successive heart rate differences)+(2* Homocysteine value)+(LF/HF ratio value)+ Omega3 index value+ Recovery index value during sleep)*10)/26 .

Finally, the value of Group 4 can be determined according to the following formula: Group 4 value= Σ (((3*Healthquestionnairevalue)+(5*Speedefforttestvalue)+(5*Powerefforttestvalue)+(4*Heartamplitudevalue)+(4 *Speedtest value and a root mean square value of successive heart rate differences)+(2*Aesthetic test value)+(2*Visual test value)+(3*Vestibular test value)+(2*Ferritin value)+Homa index value+Zinc value+Elenium value+ (4*CRP value) +(2*Immunity test value))*10)/39 .

[0032] In summary, the method of WO2016110734 makes it possible to determine a numerical score representative of the general health of a patient according to a weighting of the values of health indicators of a patient.

To perform the method described in WO2016110734, the calculation unit calculates a score stored in a storage unit accessible from the master server, the intermediate server or the electronic capture device.

In one embodiment of the invention, each of the input means comprises a keyboard for manual data entry as well as an input for computerized data.

According to this embodiment, each intermediate server and the calculation unit separately process the data of each patient.

Still according to this embodiment, each of said input means comprises a device for storing and for displaying the general health score of each patient.

In one embodiment, the calculation unit is configured to calculate the health score according to at least three and preferably at least four parameters representing different values of health indicators.

According to this embodiment, the calculation unit is configured to calculate the health score according to weighted values of four groups of parameters, representing different values of health indicators corresponding respectively to indicators of oxidative stress, digestive brain functions, reptilian brain functions and general health of a patient.

[0039] Still according to this embodiment, the calculation unit is configured to calculate the health score by taking into account the values of the cardiac amplitude, the perception time and the omega 3 index.

[0040] In one embodiment, the input means electronic sensing device is a smartphone, a connected watch and/or a heart rate monitor.

In another embodiment, the input means with the electronic capture device with the intermediate server are grouped in a single device or are integrated into several devices grouped in the same place, in principle in the doctor's office. treating.

Thus the system according to the invention will have as many input means, each with an intermediate server, as there are doctors, each doctor taking care of one or more patients.

The characteristics of the present invention will appear more clearly on reading several embodiments given solely by way of example, in no way limiting with reference to the schematic figure, in which: FIG. 1 represents a schematic view of part of the system illustrating the monitoring of a patient through his smartphone, an intermediate server and a master server; and FIG. 2 represents a schematic view of a system illustrating the monitoring of five patients, each through their smartphone, two intermediate servers and a master server;

[0044] FIG. 1 illustrates part of a system for processing values of health indicators of a patient to determine for this patient a numerical score representative of his general health. The system comprises a database 1 comprising a series of health indicator values calibrated according to standardized values, one or more input means 2A, 2B, 2C of a series of health indicator data of a patient among said standardized values, a storage unit 3A, 3B of data received by the input means 2A, 2B, 2C and a calculation unit 4 of a numerical score representative of the general health of a patient according to a weighting patient health indicator values.

In this example, the database 1 and the storage unit 3A are located in a master server 8 where the calculation unit 4 is located.

In this example, the input means 2C comprise a smartphone 5 comprising a sensor arranged to receive raw health indicator data from the patient and to calibrate, using electronic components, this raw data according to the standardized values of the database.

[0047] In this execution, the smartphone 5 is connected to a connected watch 9 and a cardiac belt 10.

The storage unit 3B is integrated in an intermediate server 7 and on the other hand the storage unit 3A is integrated in the master server 8 while the calculation unit 4 is entirely in the master server 8.

The database 1 contains for example a group of indicators relating to oxidative stress relating to the functions of the digestive brain, relating to the functions of the reptilian brain, and relating to the physical abilities of the patient coupled with his information on his general state of health. , quantified according to the indications of WO2016110734.

The various input means 2A, 2B, 2C correspond either to the keyboard of the master server, or to the keyboard of the intermediate server or to the keyboard of a smartphone. These different input means are arranged to enter raw values of all the health indicators according to the groups stored in the database 1. In this example, the data entered through the smartphone 5 or the intermediate server 7 are calibrated by the master server which instantly returns the health score. In another example, the data entered is automatically calibrated at the smartphone or intermediate server level in order to calculate a health score.

In this example, and usually, each intermediate server 7 is managed by each doctor who can thus follow the progress of each of his patients. The intermediate server 7 communicates with the master server 8 constituting a platform for exchanging health score data calculated by the calculation unit 4 of each intermediate server 7 and for storing the general health score of each patient at a place associated with said specific input means for the patient, normally in the intermediate server 7 which transmits the score to the smartphone 5.

[0052] The calculation unit 4 of a digital score representative of the general health of a patient is arranged to calculate the health score of a patient instantaneously at each manual or automatic integration in the input means 2A, 2B, 2C of data of a value of a health indicator influencing said health score. In this way, the general health score of each patient stored in the data exchange platform associated with the specific input means for the patient is automatically updated.

[0053] Indeed, for example at each sporting activity, the patient's smartphone 5, connected to a connected watch 9 and to a cardiac belt 10, records the data influencing the health score, and transmits them to the intermediate server 7 which itself transmits them to the master server 8. Thus, the patient's health score is automatically updated by the calculation unit 4 located in the master server 8.

The calculation unit 4 in the master server 8 can for example comprise a computer module programmed to calculate a numerical score representative of the general health of a patient according to a weighting of the health indicator values of a patient, for example, according to the algorithm described in the publication WO201611734. In the same way, when the doctor enters on the intermediate server 7 values influencing the health score of a patient, in particular in the context of blood test results, the calculation unit 4 in the master server 8 recalculates the patient's health score immediately and the patient can instantly view his new health score, for example on his smartphone 5.

[0055] A telephone application allows the patient to access his health score and follow its evolution over time, on a daily, weekly or monthly basis.

The measured values of the indicators make it possible to establish for each of said indicators a score as a function of the value measured with respect to reference values.

To perform the method described in WO2016110734, the input means 2A, 2B, 2C or the intermediate server 7 stores a value for each of the four groups made up of said indicators, each said group representing information corresponding respectively to oxidative stress, hereafter group 1; the functions of the gastrointestinal system, hereinafter group 2; to the functions of the nervous system, hereinafter group 3; and the physical aptitudes of the patient coupled with his information on his general state of health, hereinafter group 4.

Finally, the calculation unit 4, located in the master server 8, calculates by a computerized algorithm a health score S specific to the patient, on a scale ranging from 0 to 100, using the formula S = Σ (Value group 1+ (2* Value group 2) + (2* Value group 3) + (3* Value group 4) / (2* Number of groups).

For example, a patient whose group 1 value is 49.17, group 2 value is 47.27, group 3 value is 86.92 and group 4 value is 99.12 would have a health score S =76.86.

In this example, the closer the value of the health score is to the value 100, the healthier the patient.

As illustrated in FIG. 2, a system for processing the health indicator values of five patients to determine for each patient a numerical score representative of general health comprises a database in the intermediate server 7 and in the master server 8 comprising a series of health indicator values calibrated according to standardized values, means for inputting a series of health indicator data for each patient from among the standardized values, a storage unit 3A, 3B in the intermediate server 7 and in the master server 8 of data received by the input means 2A, 2B, 2C and a calculation unit 4 in the master server 8 of a numerical score representative of the general health according to a weighting health indicator values.

In this example, the input means 2A, 2B, 2C comprise a smartphone 5 for each patient, i.e. five smartphones 5 each comprising a sensor 6 arranged to receive raw health indicator data from each patient and to calibrate (either in the smartphone 5 or in the intermediate server 7 this raw data according to the standardized values of the database.

[0063] The storage unit and the calculation unit are integrated in each smartphone, in each of the two intermediate servers and in a master server, the two intermediate servers and the master server receiving by a means of communication the data calibrated according to the standardized values from the database.

In this example, the first intermediate server 7 makes it possible to follow two patients and the second intermediate server 7 makes it possible to follow three patients. Thus, each doctor can follow the evolution of each of his patients. Each intermediate server 7 communicates with the master server 8 constituting a platform for exchanging health score data calculated by the calculation unit 4 and for storing the general health score of each patient at a location associated with said means specific input for the patient.

[0065] The unit for calculating a numerical score representative of the general health of a patient is arranged to calculate the health score of a patient instantaneously each time integration, manual or automatic, of data from a value of a health indicator influencing said health score, so that the general health score of each patient stored in the data exchange platform associated with said specific input means for the patient is automatically updated by the master server.

[0066] Indeed, for example at each sports activity, the smartphone of each patient records the data influencing the health score, and transmits them to the remote server which itself transmits them to the master server. Thus, the patient's health score is automatically updated by the master server.

[0067] In the same way, when each of the two doctors enters on the intermediate server 7 values influencing the health score, in particular in the context of blood test results, each patient can instantly view his new health score. health.

For example, a period of four months makes it possible to establish significant changes having a real impact on health. It is only at the end of this period that the improvement of the blood balance and the quality of sleep will be visible, the best indicator of the function of the patient's reptilian brain. The comparative analysis of the pre and post-program assessments will demonstrate the improvement on the patient's health score.

Claims (9)

1. System for processing values of health indicators of at least one patient to determine for each patient a numerical score representative of the general health of the patient, the system comprising: – a database (1) comprising a series of values of health indicators calibrated according to standardized values; – one or more input means (2A, 2B, 2C) of a series of patient health indicator data from among said standardized values; – a storage unit (3A, 3B) for data received by the input means (2A, 2B, 2C); and – a calculation unit (4) of a numerical score representative of the general health of a patient according to a weighting of the values of health indicators of a patient; characterized in that said at least one input means (2A, 2B, 2C) comprises an electronic sensing apparatus (5) comprising at least one sensor (6) arranged to receive raw health indicator data from a patient and to calibrate these raw data according to the standardized values of the database (1); there is a plurality of said input means (2A, 2B, 2C) each associated with at least one patient; each of said input means (2A, 2B, 2C) is associated with its own intermediate server (7) comprising a storage unit (3B) receiving input means (2A, 2B, 2C) associated therewith by means of communication of the data calibrated according to the standardized values of the database; the calculation unit (4) is integrated in a master server (8) receiving by a means of communication, from each intermediate server (7), the data calibrated according to the standardized values of the database; each intermediate server (7) constituting with the master server (8) a platform for exchanging data of health scores calculated by the calculation unit of the master server (8), this data exchange platform being configured to store each patient's general health score at a location associated with said patient-specific input means; and the calculation unit (4) of a numerical score representative of the general health of a patient is arranged to calculate the health score of a patient instantaneously on each integration, in the input means (2A, 2B, 2C), data of a value of a health indicator influencing said health score, so that the general health score of each patient stored in the data exchange platform associated with the so-called specific input means for the patient is automatically updated. 2. System according to claim 1, in which each of the input means (2A, 2B, 2C) comprises a keyboard for the manual input of data as well as an input for computerized data. 3. System according to claim 2, in which each intermediate server (7) and the calculation unit (4) separately process the data of each patient. 4. System according to one of claims 2 or 3, wherein each of said input means (2A, 2B, 2C) comprises a device for storing and for displaying the general health score of each patient. 5. System according to one of the preceding claims, where the calculation unit (4) is configured to calculate the health score according to at least three and preferably at least four parameters representing different values of health indicators. 6. System according to claim 5, wherein the calculation unit (4) is configured to calculate the health score according to weighted values of four groups of parameters, representing different values of health indicators corresponding respectively to the indicators of oxidative stress , digestive brain functions, reptilian brain functions and the general health of a patient. 7. System according to claim 5 or 6, in which the calculation unit is configured to calculate the health score by taking into account the values of the cardiac amplitude, the perception time and the omega 3 index. 8. System according to one of the preceding claims, in which the electronic sensor device (5) of the input means is a smartphone, a connected watch (9) or a cardiac belt (10). 9. System according to one of the preceding claims, in which the input means (2A, 2B, 2C) with the electronic capture device (5) with the intermediate server (7) are grouped in a single device or are integrated into multiple devices grouped in one place.