CH661878A5 - CAPSULE DOSING FORMS. - Google Patents

CAPSULE DOSING FORMS. Download PDF

Info

Publication number
CH661878A5
CH661878A5 CH4939/84A CH493984A CH661878A5 CH 661878 A5 CH661878 A5 CH 661878A5 CH 4939/84 A CH4939/84 A CH 4939/84A CH 493984 A CH493984 A CH 493984A CH 661878 A5 CH661878 A5 CH 661878A5
Authority
CH
Switzerland
Prior art keywords
capsule
units
water
parts
starch
Prior art date
Application number
CH4939/84A
Other languages
German (de)
Inventor
Fritz Wittwer
Louis S Gillow
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CH661878A5 publication Critical patent/CH661878A5/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/56—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using mechanical means or mechanical connections, e.g. form-fits
    • B29C65/58—Snap connection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/114—Single butt joints
    • B29C66/1142—Single butt to butt joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/13—Single flanged joints; Fin-type joints; Single hem joints; Edge joints; Interpenetrating fingered joints; Other specific particular designs of joint cross-sections not provided for in groups B29C66/11 - B29C66/12
    • B29C66/131—Single flanged joints, i.e. one of the parts to be joined being rigid and flanged in the joint area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/13—Single flanged joints; Fin-type joints; Single hem joints; Edge joints; Interpenetrating fingered joints; Other specific particular designs of joint cross-sections not provided for in groups B29C66/11 - B29C66/12
    • B29C66/131—Single flanged joints, i.e. one of the parts to be joined being rigid and flanged in the joint area
    • B29C66/1312—Single flange to flange joints, the parts to be joined being rigid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2422—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being circular, oval or elliptical
    • B29C66/24221—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being circular, oval or elliptical being circular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2424—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain
    • B29C66/24241—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain forming a triangle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2424—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain
    • B29C66/24243—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain forming a quadrilateral
    • B29C66/24244—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being a closed polygonal chain forming a quadrilateral forming a rectangle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/543—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining more than two hollow-preforms to form said hollow articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/63—Internally supporting the article during joining
    • B29C66/636—Internally supporting the article during joining using a support which remains in the joined object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/545—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles one hollow-preform being placed inside the other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Fertilizers (AREA)
  • Packages (AREA)

Description

Die vorliegende Erfindung betrifft Dosierungsformen von hartschaligen Kapseln zur dosierten Verabreichung von festen, cremigen und flüssigen Substanzen, insbesondere Pharmazeutikas. The present invention relates to dosage forms of hard-shell capsules for the metered administration of solid, creamy and liquid substances, in particular pharmaceuticals.

Die Dosierungsform der vorliegenden Erfindung besteht aus zwei oder mehreren Kapseln, die miteinander verbunden sind. Dabei können die Verbindungsstücke der Kapseln in einem Arbeitsgang mit der Kapselherstellung durch Druckformen und aus denselben Materialien wie die Kapseln hergestellt werden. Weiter können die Kapseln zwei oder mehrere nicht trennbare Abschnitte oder Sektoren in jeder Kapsel enthalten, um verschiedene Medikamente aufzunehmen. Die erfindungsgemässen Kapselarten können als eine Vielzahl von Einzeldosierungen oder als Packungen hergestellt werden. Bisher bekannte Kapseln für den pharmazeutischen Gebrauch haben nur einen einzigen Behälter zum Aufnehmen von Füllmaterial, nämlich den durch das Zusammenschieben von Kappen- und Körperteil erhaltenen Hohlraum der Kapsel. The dosage form of the present invention consists of two or more capsules connected together. The capsule connecting pieces can be produced in one step with the capsule production by printing forms and from the same materials as the capsules. Furthermore, the capsules can contain two or more inseparable sections or sectors in each capsule to accommodate different medications. The types of capsules according to the invention can be produced as a large number of individual doses or as packs. Previously known capsules for pharmaceutical use have only a single container for holding filling material, namely the cavity of the capsule obtained by pushing the cap and body parts together.

Es ist bekannt, dass Tabletten für den Patienten die Möglichkeit bieten, die Dosierung z.B. durch Auseinanderbrechen in Stücke zu wählen. Gemäss der vorliegenden Erfindung können nun mit Druckformtechniken, vorzugsweise mittels Spritzguss, Kapseln hergestellt werden, die zwei oder mehrere Medikamente enthalten, die nicht in einer Tablette oder in bisher üblichen Kapseln kombiniert werden konnten, da ihre Aktivsubstanzen, z.B. miteinander zu unerwünschten Produkten reagieren. It is known that tablets offer the patient the option of e.g. to choose by breaking apart into pieces. According to the present invention, capsule containing two or more medicaments which could not be combined in a tablet or in capsules which were customary hitherto can now be produced using compression molding techniques, preferably by means of injection molding, since their active substances, e.g. react with each other to unwanted products.

•Kapseldosierungsformen gemäss der vorliegenden Erfindung können in kleinere Einheiten geteilt und geschluckt werden. Die Artikel der vorliegenden Erfindung können durch Druckformen, vorzugsweise Spritzgiessen von Stärke, hydrophilen Polymeren wie Gelatine, oder Stärkederivaten, alle mit niedrigen Wassergehalten, hergestellt werden. Capsule dosage forms according to the present invention can be divided into smaller units and swallowed. The articles of the present invention can be made by compression molding, preferably injection molding starch, hydrophilic polymers such as gelatin, or starch derivatives, all with low water contents.

Beim Spritzgiessen ist es wichtig, dass das zu formende, geschmolzene Material sich während des Formprozesses wie ein thermoplastisches Material verhält und anschliessend so schnell in der Form erstarrt, dass es rasch und ohne Dimensionsänderung aus der Form ausgestossen werden kann. Letzteres ist deshalb von besonderer Wichtigkeit, da von den meisten druckgeformten Artikeln hohe Formstabilität verlangt wird. Die erfindungsgemässen Artikel kann man mit höchster Genauigkeit und Dimensionsstabilität durch Druckformen, insbesondere Spritzgiessen, herstellen. In injection molding, it is important that the molten material to be molded behaves like a thermoplastic material during the molding process and then solidifies in the mold so quickly that it can be ejected from the mold quickly and without changing its dimensions. The latter is therefore of particular importance, since most of the pressure-molded articles require a high degree of dimensional stability. The articles according to the invention can be produced with the greatest accuracy and dimensional stability by pressure molding, in particular injection molding.

Das Verfahren zur Herstellung der erfindungsgemässen Kapselformen ist dadurch gekennzeichnet, dass diese hergestellt werden aus einem hydrophilen Polymeren oder einer Mischung solcher Polymere mit einem Wassergehalt von 5—25% (berechnet auf die hydrophile Polymer/Wasser-Mischung), wobei für den Fall, dass die Kapselformen aus Gelatine hergestellt werden, diese einen Wassergehalt von 10—20 Gew.% (berechnet auf die wasserhaltige Gelatine-Wasser-Mischung) aufweist, und für den Fall, dass diese aus Stärke oder einer Stärkemischung hergestellt werden, letztere einen Wassergehalt von 5—25 Gew.%, vorzugsweise 15—21 Gew.% (berechnet auf die Stärke/Wasser-Mischung) aufweist. The method for producing the capsule forms according to the invention is characterized in that they are produced from a hydrophilic polymer or a mixture of such polymers with a water content of 5-25% (calculated on the hydrophilic polymer / water mixture), in which case the capsule forms are made of gelatin, which has a water content of 10-20% by weight (calculated on the water-containing gelatin-water mixture), and in the event that they are produced from starch or a starch mixture, the latter has a water content of 5 - 25% by weight, preferably 15-21% by weight (calculated on the starch / water mixture).

Die vorliegende Erfindung betrifft teilbare hartschalige Kapselformen, dadurch gekennzeichnet, dass die einzelnen Kapseleinheiten, bestehend jeweils aus einem Kappenteil und einem Körperteil, die ineinander schiebbar sind, miteinander derart verbunden sind, dass die einzelnen Kapseleinheiten leicht voneinander abgetrennt werden können. The present invention relates to divisible hard-shell capsule shapes, characterized in that the individual capsule units, each consisting of a cap part and a body part which can be pushed into one another, are connected to one another in such a way that the individual capsule units can be easily separated from one another.

Die vorliegende Erfindung betrifft auch hartschalige Kapselformen, bestehend aus einem Kappenteil und einem Körperteil, dadurch gekennzeichnet, dass der Körperteil mehrere Abteilungen aufweist. Diese einzelnen Kapseleinheiten können mittels einer oder mehreren Lamellen zu grösseren Einheiten verbunden sein. Dabei kann der Körperteil und/oder der Kappenteil mit einer Lamelle verbunden sein. The present invention also relates to hard-shell capsule forms, consisting of a cap part and a body part, characterized in that the body part has several departments. These individual capsule units can be connected to larger units by means of one or more lamellae. The body part and / or the cap part can be connected to a lamella.

Die Erfindung betrifft im weiteren hartschalige Kapselpackungen, dadurch gekennzeichnet, dass die einzelnen Kapseleinheiten, jeweils bestehend aus einem Kappenteil und einem Körperteil die ineinander schiebbar sind, derart miteinander verbunden sind, dass die einzelnen Kapseleinheiten leicht voneinander abgetrennt werden können. Die verbundenen Kapseleinheiten der vorliegenden Erfindung sind vorzugsweise durch eine oder mehrere dünne Lamellen miteinander verbunden; diese verbundenen Einheiten werden vorzugsweise in einem einzigen Arbeitsgang mittels des Spritzgussverfahrens hergestellt. The invention further relates to hard-shell capsule packs, characterized in that the individual capsule units, each consisting of a cap part and a body part which can be pushed into one another, are connected to one another in such a way that the individual capsule units can be easily separated from one another. The interconnected capsule units of the present invention are preferably interconnected by one or more thin lamellae; these connected units are preferably produced in a single operation by means of the injection molding process.

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Erfmdungsgemäss können die einzelnen Kapseleinheiten oder die einzelnen Abteilungen eines Körperteils z.B. mit unterschiedlichen Medikamenten gefüllt werden. According to the invention, the individual capsule units or the individual departments of a body part can e.g. be filled with different medicines.

Die Kapseleinheiten können zur genauen Dosierung von festen, flüssigen und cremigen Substanzen, hauptsächlich im pharmazeutischen Bereich, verwendet werden. The capsule units can be used for the precise dosing of solid, liquid and creamy substances, mainly in the pharmaceutical field.

Bevorzugte Kapseln gemäss der vorliegenden Erfindung werden aus Stärke im Spritzgussverfahren hergestellt. Preferred capsules according to the present invention are made from starch by injection molding.

Das Spritzgiessen von hydrophilem Material, wie z.B. wasserhaltiger Gelatine, ist in der Europäischen Patentanmeldung Pub. Nr. 92 908 beschrieben und Teil der vorliegenden Erfindung. Injection molding of hydrophilic material, e.g. hydrous gelatin, is in the European Patent Pub. No. 92 908 and forms part of the present invention.

Hydrophile Polymere sind Polymere mit Molekularmassen von ungefähr IO3 bis 107 Dalton, die in ihrer Hauptkette und/oder in Seitenketten Molekülgruppen enthalten, die imstande sind, Wasserstoffbrücken zu bilden und/oder an solchen teilzunehmen. Die Bearbeitungstemperaturen für diese Materialien liegen im Bereich von vorzugsweise 70—190 °C, vorzugsweise 80—190 °C. Hydrophilic polymers are polymers with molecular masses of approximately IO3 to 107 daltons which contain molecular groups in their main chain and / or in side chains which are capable of forming and / or participating in hydrogen bonds. The processing temperatures for these materials are in the range of preferably 70-190 ° C, preferably 80-190 ° C.

Wird als hydrophiles Polymer Gelatine verwendet, so ist diese hergestellt z.B. durch saure oder alkalische Behandlung von Kollagen, saure Behandlung von Schweinehaut oder alkalische Behandlung von Rinderhäuten. Diese Gelatinearten besitzen Molekularmassen vorzugsweise im Bereich von 10 000 bis 2 x 107 Dalton oder Molekularmassen im Bereich von 10 000 bis 2 x 106 und 10 x 106 bis 20 x 106 Dalton. Die verwendete Gelatine hat einen Wassergehalt von vorzugsweise 10—19%, besonders bevorzugt von 12—18 Gew.% bezogen auf die wasserhaltige Gelatinemischung. If gelatin is used as the hydrophilic polymer, this is produced e.g. by acidic or alkaline treatment of collagen, acidic treatment of pig skin or alkaline treatment of cattle hides. These types of gelatin preferably have molecular weights in the range from 10,000 to 2 x 107 daltons or molecular weights in the range from 10,000 to 2 x 106 and 10 x 106 to 20 x 106 daltons. The gelatin used has a water content of preferably 10-19%, particularly preferably 12-18% by weight, based on the water-containing gelatin mixture.

Allen hydrophilen Polymeren, einschliesslich der Gelatine, können verschiedene Zusatzstoffe wie Plastifiziermittel, Gleitmittel, Vernetzungsmittel und Farbstoffe — wie in der Europäischen Patentanmeldung Pubi. No. 92 908 beschrieben — zugesetzt werden. Die hydrophilen Polymere können ausserdem bis zu 95% — vorzugsweise nicht mehr als 30 Gew.% Streckmittel, wie Proteine z.B. Sonnenblumenproteine, Sojabohnenproteine, Baumwollsaatproteine; Erdnuss-proteine, Blutproteine, Eierproteine, Rapssaatproteine und deren acrylierte Derivate, quervernetzte Gelatine, Vinylace-tate, Polysaccharide wie Cellulose, Methylcellulose, Hydro-xymethylcellulose, Natriumcarboxymethylcellulose, Agar-Agar, Gummi Arabicum, Guar, Dextran, Chitin, Polymalto-se, Polyfructose, Pectin, Alginate, Alginatsäure, Monosaccharide wie Glukose, Fruktose, Saccharose, Oligosaccharide, wie Laktose, Polyvinylpyrrolidon, Silikate, Bentonite, Karbonate oder Bikarbonate enthalten. Various additives such as plasticizers, lubricants, crosslinking agents and dyes can be added to all hydrophilic polymers, including gelatin - as in the European patent application Pubi. No. 92 908 described - are added. The hydrophilic polymers can also contain up to 95% - preferably not more than 30% by weight of extenders such as proteins e.g. Sunflower proteins, soybean proteins, cottonseed proteins; Peanut proteins, blood proteins, egg proteins, rapeseed proteins and their acrylated derivatives, cross-linked gelatin, vinyl acetate, polysaccharides such as cellulose, methyl cellulose, hydroxymethyl cellulose, sodium carboxymethyl cellulose, agar agar, gum arabic, guar, dextran, chitin, polymalto Contain polyfructose, pectin, alginates, alginate acid, monosaccharides such as glucose, fructose, sucrose, oligosaccharides such as lactose, polyvinylpyrrolidone, silicates, bentonites, carbonates or bicarbonates.

Manche dieser Streckmittel sind ihrerseits hydrophile Polymere und können als solche zur Herstellung erfindungsge-mässer Artikel verwendet werden. Solche hydrophile Polymere sind Hydroxypropylmethylcellulosephthalat (HPMCP) Polyvinylacetatphthalat (PVAP), Celluloseacetylphthalat (CAP), Acrylate und Methacrylate, mit Phthalsäure, Bernsteinsäure oder Crotonsäure behandelte Gelatine und Schellack. Diese Polymere sind dann bevorzugt, wenn Entero-Eigenschaften erwünscht sind. Sie enthalten vorzugsweise 5—25% Wasser, besonders bevorzugt 15—22 Gew.% berechnet auf das wasserhaltige Polymere. Bevorzugt sind HPMCP, PVAP und CAP, besonders PVAP und CAP. Am meisten bevorzugt ist jedoch PVAP, wobei alle im Spritzgussverfahren und mit einem Wassergehalt von 5 —25%, vorzugsweise 15% —21 Gew.% bezogen auf die Mischung, verarbeitet werden. Some of these extenders are themselves hydrophilic polymers and can be used as such for the production of articles according to the invention. Such hydrophilic polymers are hydroxypropyl methyl cellulose phthalate (HPMCP) polyvinyl acetate phthalate (PVAP), cellulose acetyl phthalate (CAP), acrylates and methacrylates, gelatin treated with phthalic acid, succinic acid or crotonic acid and shellac. These polymers are preferred when Entero properties are desired. They preferably contain 5-25% water, particularly preferably 15-22% by weight based on the water-containing polymer. HPMCP, PVAP and CAP, particularly PVAP and CAP, are preferred. Most preferred, however, is PVAP, all of which are processed by injection molding and with a water content of 5-25%, preferably 15% -21% by weight, based on the mixture.

Einige dieser Polymeren sind nicht thermoplastisch und es ist daher umso überraschender, dass sie in Druckformverfahren verarbeitet werden können. Die Bearbeitungstemperatur liegt im Bereich von 70 °C bis 190 °C und der Druck im Bereich von 600 bis 3000 x 105 N/m2; wobei an sich bekannte Maschinen verwendet werden können. Some of these polymers are not thermoplastic, and it is therefore all the more surprising that they can be processed in printing form processes. The processing temperature is in the range from 70 ° C to 190 ° C and the pressure in the range from 600 to 3000 x 105 N / m2; machines known per se can be used.

Bevorzugt ist eine formbare Stärkemischung aus Korn-, Weizen-, Kartoffel-, Reis und/oder Tapiokastärke. Die Stärke enthält ca. 0 bis 100% Amylose und ca. 100 bis 0% Amylopektin, vorzugsweise 0 bis 70% Amylose und ca. 100 — 30% Amylopektin. Besonders bevorzugt ist Kartoffel-oder Maisstärke. A moldable starch mixture of corn, wheat, potato, rice and / or tapioca starch is preferred. The starch contains approximately 0 to 100% amylose and approximately 100 to 0% amylopectin, preferably 0 to 70% amylose and approximately 100 to 30% amylopectin. Potato or corn starch is particularly preferred.

Im folgenden umfassen die Begriffe «Stärke» und «Gelatine» auch Schäume, Modifikationen oder Derivate von Stärke und Gelatine und deren Kombination mit hydrophilen Polymeren, deren Eigenschaften für die Druck- bzw. Spritzformung — insbesondere zur Herstellung von Kapseln — geeignet sind. In the following, the terms “starch” and “gelatin” also include foams, modifications or derivatives of starch and gelatin and their combination with hydrophilic polymers, the properties of which are suitable for pressure or injection molding, in particular for the manufacture of capsules.

Die zu verwendende Stärke hat einen Wassergehalt von 5 — 25%, vorzugsweise 15 — 21% und besonders bevorzugt 17—20 Gew.% bezogen auf die Stärkemischung. Sie kann ausserdem verschiedene Additive wie Plastifiziermittel, Gleitmittel, Vernetzungsmittel und/oder Farbstoffe sowie Streckmittel enthalten. Hierfür können dieselben Verbindungen wie oben für die hydrophilen Polymere beschrieben, verwendet werden. Die Bearbeitungstemperatur zum Spritzgiessen von Stärke liegt zwischen 80° und 240 C, bei einem Druck im Bereich von 600 bis 3000 x 105 N/m2. The starch to be used has a water content of 5-25%, preferably 15-21% and particularly preferably 17-20% by weight, based on the starch mixture. It can also contain various additives such as plasticizers, lubricants, crosslinking agents and / or dyes and extenders. The same compounds as described above for the hydrophilic polymers can be used for this. The processing temperature for the injection molding of starch is between 80 ° and 240 C, at a pressure in the range of 600 to 3000 x 105 N / m2.

Die wasserhaltige, gegebenenfalls noch weitere Zusatzstoffe enthaltende Stärke wird bei diesen Temperaturen und Drucken und in bekannten Spritzgussmaschinen in an sich bekannter Weise verarbeitet. The water-containing starch, which may contain further additives, is processed at these temperatures and pressures and in known injection molding machines in a manner known per se.

Erfindungsgemässe Artikel können auch durch Profilex-trudieren, Formgiessen, Vakuumformen, thermisches Formen, Extrudieren, Giessen in Kombination mit Vakuumformen hergestellt werden. Bevorzugt ist jedoch das Spritzgiessen. Articles according to the invention can also be produced by profile extrusion, molding, vacuum molding, thermal molding, extrusion, casting in combination with vacuum molding. However, injection molding is preferred.

Die Vorteile der vorliegenden Erfindung werden durch die folgende detaillierte Beschreibung näher erläutert. The advantages of the present invention are explained in more detail by the following detailed description.

Detaillierte Beschreibung Detailed description

Die Ausführungsformen der vorliegenden Erfindung können in 3 Gruppen eingeteilt werden. The embodiments of the present invention can be divided into 3 groups.

1) Teilbare oder trennbare Kapsel 1) Divisible or separable capsule

Die teilbare Kapsel kann ungeteilt geschluckt werden oder sie kann in Teile geteilt werden, die einzeln geschluckt werden können. Aus diesem Grund haben sowohl die verbundenen Kapseln als auch die abgetrennten Stücke eine Form, die leicht geschluckt werden kann und die zusätzlich das Anwendungsgebiet angeben kann. Der Körperteil oder der Kappenteil oder beide Teile können durch eine Lamelle verbunden sein. Eine Ausführungsform dieser Gruppe ist in Fig. 1, 2, 3 und 4 gezeigt, die eine perspektivische Ansicht einer teilbaren Kapsel, bestehend aus 2 Einheiten, jeweils bestehend aus einem Kappenteil 2 und einem Körperteil 1, darstellt. Wie aus Fig. 2, die einen Schnitt entlang der Linie 2 —2 von Fig. 1 zeigt, hervorgeht, sind die beiden Körperteile 1 durch eine schwache Lamelle 5 verbunden. Die beiden Kappenteile 2 sind hingegen nicht verbunden. Fig. 3, die eine weitere Ansicht von Fig. 1 darstellt, zeigt diese Dosierungsform nach dem Füllen, oder vor dem Aufsetzen der Kappenteile 2 auf die Körperteile 1. Fig. 4 ist eine Seitenansicht von Fig. 3 nach dem Aufsetzen der Kappenteile 2 auf die Körperteile 1. Diese Ausführungsform gemäss Fig. 1 —4 kann als ganze Kapsel geschluckt werden, oder aber sie kann entlang der Lamelle 5 in kleinere Einheiten geteilt werden, die ihrerseits einzeln geschluckt werden können. Die beiden Teile der teilbaren Kapsel gemäss Fig. 1 —4 können mit verschiedenen oder mit demselben Medikament gefüllt werden. Im Falle des Einfüllens desselben Medikaments, wird die Dosis duch das Auseinanderbrechen halbiert. Füllt man jedoch 2 verschiedene Medikamente in die beiden Kapselteile, so kann die erwünschte Kombination durch Abbrechen der The divisible capsule can be swallowed whole or it can be divided into parts that can be swallowed individually. For this reason, both the connected capsules and the separated pieces have a shape that can be easily swallowed and that can also indicate the area of application. The body part or the cap part or both parts can be connected by a lamella. An embodiment of this group is shown in FIGS. 1, 2, 3 and 4, which represents a perspective view of a separable capsule, consisting of 2 units, each consisting of a cap part 2 and a body part 1. As can be seen from FIG. 2, which shows a section along the line 2-2 of FIG. 1, the two body parts 1 are connected by a weak lamella 5. The two cap parts 2, however, are not connected. FIG. 3, which represents a further view of FIG. 1, shows this dosage form after filling, or before the cap parts 2 have been placed on the body parts 1. FIG. 4 is a side view of FIG. 3 after the cap parts 2 have been put on the body parts 1. This embodiment according to FIGS. 1-4 can be swallowed as a whole capsule, or else it can be divided along the lamella 5 into smaller units, which in turn can be swallowed individually. The two parts of the divisible capsule according to FIGS. 1-4 can be filled with different or with the same medication. In the case of filling in the same medication, the dose is halved by breaking apart. However, if 2 different medications are filled into the two capsule parts, the desired combination can be canceled

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Kapsel an der Lamelle geschluckt werden. Um den Inhalt der beiden Teile zu kennzeichnen, können die beiden Teile entweder in verschiedenen Farben hergestellt oder verschieden bedruckt werden. Die Kapselteile 1 und 2 sowie die sie verbindende Lamelle 5 können in einem Arbeitsgang durch Druckformen, vorzugsweise Spritzgiessen, hergestellt werden. Das Verbindungsstück 5 besteht aus demselben Material wie die Kapselteile 1 und 2. Capsule to be swallowed by the lamella. To mark the content of the two parts, the two parts can either be made in different colors or printed differently. The capsule parts 1 and 2 and the lamella 5 connecting them can be produced in one operation by pressure molding, preferably injection molding. The connecting piece 5 is made of the same material as the capsule parts 1 and 2.

Fig. 5 und 6 zeigen eine weitere Ausführungsform einer Kapsel mit 4 Unterteilungen. Fig. 5 ist ein Grundriss und Fig. 6 ist eine Seitenansicht von Fig. 5, die 4 Kappenteile 2 und 4 Körperteile 1, die durch eine schwache Lamelle 5 miteinander verbunden sind, zeigen. Diese Kapsel kann als ganze oder die 4 Teile können einzeln eingenommen, werden. Die Kapselteile bzw. Unterteilungen können mit demselben oder verschiedenen Medikamenten gefüllt werden. Weitere Aus-führungsformen sind in Fig. 7 bis 12 dargestellt. Die Zahlen-Bezeichnungen sind hierbei wie in Fig. 1—6. Bei dieser Aus-führungsform sind die Kappenteile 2 mit den Körperteilen 1 durch schwache Verbindungen wie in Fig. 11 und 12 gezeigt, verbunden. Die Kappenteile 2 können die Körperteile 1 überlappen. Weiter können die Kappenteile 2 von der Verbindungsstelle der Lamelle 5 eine Einbuchtung 6 aufweisen, so dass die Lamelle auch nach dem Auseinanderbrechen der Einzelteile schwer sichtbar ist. 5 and 6 show a further embodiment of a capsule with 4 divisions. Fig. 5 is a plan view and Fig. 6 is a side view of Fig. 5 showing 4 cap parts 2 and 4 body parts 1 connected by a weak sipe 5. This capsule can be taken as a whole or the 4 parts can be taken individually. The capsule parts or subdivisions can be filled with the same or different medications. Further embodiments are shown in FIGS. 7 to 12. The numerical designations here are as in FIGS. 1-6. In this embodiment, the cap parts 2 are connected to the body parts 1 by weak connections as shown in FIGS. 11 and 12. The cap parts 2 can overlap the body parts 1. Furthermore, the cap parts 2 can have an indentation 6 from the connection point of the lamella 5, so that the lamella is difficult to see even after the individual parts have broken apart.

Eine andere Ausführungsform ist in Fig. 13 und 14 dargestellt, worin die Kapsel aus 3 Teilen besteht, die einen inneren und 2 äussere Teile aufweisen, wovon jede davon wiederum aus einem Körperteil 1 und einem Kappenteil 2 besteht. In Fig. 13 und 14 sind die äusseren Teile dreieckig geformt. Andererseits können die äusseren Teile wie in Fig. 15 und 16 eine halbkreisartige Form aufweisen. Gemäss den Ausführungsformen in Fig. 13 — 16 sind nur die Körperteile 1 mit Lamellen 5 verbunden, die Kappen sind jedoch Einzelteile. Another embodiment is shown in FIGS. 13 and 14, in which the capsule consists of 3 parts, which have an inner and 2 outer parts, each of which in turn consists of a body part 1 and a cap part 2. 13 and 14, the outer parts are triangular. On the other hand, the outer parts may have a semicircular shape as in FIGS. 15 and 16. According to the embodiments in FIGS. 13-16, only the body parts 1 are connected to slats 5, but the caps are individual parts.

3) Kapselpackung 3) capsule pack

Eine Kapselpackung besteht aus 2 oder mehreren Kapseln, die so miteinander verbunden sind, dass sie in einzelne Kapsel-Einheiten abgetrennt werden können. Diese Kapselpackungen sollen nicht als ganzes geschluckt werden, sondern stellen eher eine geeignete Lagerform dar z. B. für den Fall, dass jede Einheit periodisch eingenommen werden soll. A capsule pack consists of 2 or more capsules that are connected to each other so that they can be separated into individual capsule units. These capsule packs should not be swallowed whole, but rather represent a suitable form of storage z. B. in the event that each unit should be taken periodically.

Die Zahl der gesamthaft verbundenen Teile ist nicht begrenzt. Kapselpackungen können auch dazu benutzt werden, um teilbare Kapseln der Gruppe 1 und in Kammern unterteilte Kapseln der Gruppe 2 zu kombinieren. Eine Ausführungsform dieser Gruppe ist in Fig. 17 und 18 dargestellt. Fig. 12 ist ein Grundriss, der die Kapseln entlang ihrer Achse aufgereiht zeigt. Fig. 18 ist ein Schnitt von Fig. 17 entlang der Linie 22, worin man die Verbindung der Kapselkörper 1 durch die Lamellen 5, die aus demselben Material wie die Kapselkörper 1 bestehen und durch gleichzeitiges Druckformen erhalten wurden, erkennt. Die Kappenteile 2 der Kapselpackung sind nicht miteinander verbunden. Sowohl die Körperteile 1 als auch die Kappenteile 2 können mit Verschlussmechanismen versehen werden, um einen trennsicheren Verschluss zu erhalten. Eine andere Ausführungsform der Kapselpackung ist in Fig. 19 und 24 dargestellt. Fig. 19 ist ein Grundriss, der kreisförmige Anordnung der Kapseleinheiten zeigt. Fig. 20 ist ein Schnitt längs der Linie 24—24 von Fig. 19, wobei die Kapselkörper 1 durch die Verbin-s dungsstücke 5 miteinander verbunden sind, die aus demselben Material wie die Kapselkörper 1 bestehen. Diese Verbindungsstücke 5 werden gleichzeitig mit den Kapselkörpern hergestellt. Beide Teile, d.h. die Körper 1 und die Kappen 2 können auch mit Verschlussmechanismen versehen werden, io Eine andere Ausführangsform der Kapselpackung wird in Fig. 21 und 22 dargestellt; sie dient zur Kombination 2er verschiedener Medikamente. Fig. 21 ist ein Grundriss, der die Kapseln an dem Verbindungsstück 5 hängend, zeigt. Fig. 22 ist ein Schnitt längs der Linie 26—26 von Fig. 21, der i5 zeigt, wie Kapselkörper 1 und Kappen 2 gleichzeitig ohne Druckformen hergestellt werden. Die Kappenteile sind nicht miteinander verbunden. Die Kapseln sind in 2 Reihen angeordnet, so dass die 2 Medikamente in die aneinander stos-senden Körperteile gefüllt werden können.. 20 Durchdrückpackungen, sog. Blisterpackungen sind zum Verpacken von pharmazeutischen und anderen Produkten die eine hohe Dosierungsgenauigkeit erfordern, bekannt. Es ist ein weiteres Merkmal der vorliegenden Erfindung, dass man hartschalige Kapseln aus den Blisterpackungskompo-25 nenten einer Blisterschale und eines Deckblattes, die mit Hitze und Druck verschweisst wurden, herstellen kann, nachdem man die Blisterschale mit einem Medikament gefüllt hat. Erfindungsgemäss werden die Durchdrückpackungs-komponenten aus wasserlöslichen und essbaren hydrophilen 30 Polymeren hergestellt. The number of parts connected in total is not limited. Capsule packs can also be used to combine group 1 divisible capsules and group 2 capsules divided into compartments. An embodiment of this group is shown in FIGS. 17 and 18. Figure 12 is a plan view showing the capsules lined up along their axis. Fig. 18 is a section of Fig. 17 along line 22, in which the connection of the capsule body 1 through the lamellae 5, which consist of the same material as the capsule body 1 and were obtained by simultaneous pressure molding, can be seen. The cap parts 2 of the capsule pack are not connected to one another. Both the body parts 1 and the cap parts 2 can be provided with locking mechanisms in order to obtain a secure closure. Another embodiment of the capsule pack is shown in FIGS. 19 and 24. Fig. 19 is a plan view showing the circular arrangement of the capsule units. FIG. 20 is a section along the line 24-24 of FIG. 19, the capsule bodies 1 being connected to one another by the connecting pieces 5, which are made of the same material as the capsule bodies 1. These connectors 5 are made simultaneously with the capsule bodies. Both parts, i.e. the bodies 1 and the caps 2 can also be provided with closure mechanisms, io Another embodiment of the capsule pack is shown in FIGS. 21 and 22; it is used to combine two different drugs. Fig. 21 is a plan view showing the capsules hanging on the connector 5. Fig. 22 is a section along line 26-26 of Fig. 21, showing i5 how capsule body 1 and caps 2 are made simultaneously without printing forms. The cap parts are not connected to each other. The capsules are arranged in 2 rows so that the 2 medications can be filled into the abutting body parts. 20 blister packs are known for packaging pharmaceutical and other products that require high dosage accuracy. It is a further feature of the present invention that hard-shell capsules can be produced from the blister pack components of a blister shell and a cover sheet that have been heat and pressure sealed after the blister shell has been filled with a medicament. According to the invention, the blister pack components are produced from water-soluble and edible hydrophilic polymers.

Fig. 23 ist ein Grundriss einer Ausführungsform einer Kapsel-Blisterpackung, worin der Blisterbogen 10 verschiedene Unterteilungen 11,12,13,14... hat. Fig. 24 ist ein Schnitt längs der Linie 28—28 von Fig. 23, wobei der Bli-35 sterbogen 10 mit dem Deckbogen 15 durch Druck und Hitze verschweisst wurden und die Blisterunterteilungen 11,12,13, 14 ... mit den Medikamenten darin versiegelt wurden. An der Nahtstelle des Blisterbogens 10 mit dem Deckblatt 15 können Perforationen 16 zum leichteren Abtrennen der Bli-40 sterkammern 13,14 ... angebracht werden. Fig. 25, 26,27 und 28 zeigen andere Ausführungsformen von Kapsel-Blisterpackungen, wobei dieselben Zahlenbezeichnungen wie in Fig. 23 und 24 verwendet wurden. Fig. 25 und 26 zeigen Kapsel-Blisterpackungen, wobei die Blisterbogen 10 und der 45 Deckbogen 15 symmetrische Unterteilungen 13,14 aufweisen. Fig. 27 und 28 zeigen Kapsel-Blisterpackungen bei denen jede Einheit 11 und 12 in weitere Kammern 17,18,19, 20 zur Aufnahme verschiedener Medikamente unterteilt ist. 23 is a plan view of an embodiment of a capsule blister pack in which the blister sheet has 10 different divisions 11, 12, 13, 14 ... FIG. 24 is a section along line 28-28 of FIG. 23, the blister sheet 10 being welded to the cover sheet 15 by pressure and heat and the blister divisions 11, 12, 13, 14 ... to the medication were sealed in it. At the interface between the blister sheet 10 and the cover sheet 15, perforations 16 can be attached to make it easier to separate the blister 40 chambers 13, 14 .... 25, 26, 27 and 28 show other embodiments of capsule blister packs using the same numerical designations as in Figs. 23 and 24. 25 and 26 show capsule blister packs, the blister sheets 10 and the 45 cover sheets 15 having symmetrical divisions 13, 14. 27 and 28 show capsule blister packs in which each unit 11 and 12 is subdivided into further chambers 17, 18, 19, 20 for receiving various medicaments.

Die vorliegende Erfindung umfasst auch das Versiegeln so und Verschliessen der ineinandergeschobenen Kapselteile bzw. verschlossene und versiegelte Kapseln. Dieses Versiegeln bietet einen weiteren Schutz gegen Trennung und Verfälschung des Inhalts der Kapsel, und macht die Kapsel zusätzlich feuchtigkeits- und gasdicht. Erfindungsgemässe 55 Kapseln können für pharmazeutische Zwecke, aber auch zur exakten, quantitativen Dosierung von Farbstoffen, Chemikalien, Gewürzen, Düngemittelkombinationen für Pflanzen, Düngemittel mit Schutzsubstanzen, Samen, Kosmetika, landwirtschaftliche Produkte etc. dienen. The present invention also includes the sealing and closing of the nested capsule parts or closed and sealed capsules. This sealing offers further protection against separation and falsification of the contents of the capsule, and also makes the capsule moisture and gas tight. 55 capsules according to the invention can be used for pharmaceutical purposes, but also for the exact, quantitative dosing of dyes, chemicals, spices, fertilizer combinations for plants, fertilizers with protective substances, seeds, cosmetics, agricultural products etc.

65 65

7 Blatt Zeichnungen 7 sheets of drawings

Claims (11)

661 878 PATENTANSPRÜCHE661 878 PATENT CLAIMS 1. Teilbare hartschalige Kapselformen, dadurch gekennzeichnet, dass die einzelnen Kapseleinheiten, bestehend jeweils aus einem Kappenteil und einem Körperteil, die ineinander schiebbar sind, miteinander derart verbunden sind, dass die einzelnen Kapseleinheiten leicht voneinander abgetrennt werden können. 1. Divisible hard-shell capsule shapes, characterized in that the individual capsule units, each consisting of a cap part and a body part which can be pushed into one another, are connected to one another in such a way that the individual capsule units can be easily separated from one another. 2. Kapselformen nach Patentanspruch 1, dadurch gekennzeichnet, dass diese als eine Vielzahl von Einzeldosierungen oder als Packungen hergestellt sind. 2. Capsule forms according to claim 1, characterized in that they are produced as a plurality of individual doses or as packs. 3. Hartschalige Kapselformen nach Patentanspruch 1, bestehend aus einem Kappenteil und einem Körperteil, dadurch gekennzeichnet, dass der Körperteil mehrere Abteilungen aufweist. 3. Hard-shell capsule shapes according to claim 1, consisting of a cap part and a body part, characterized in that the body part has several departments. 4. Kapselformen nach einem der Patentansprüche 1—3, dadurch gekennzeichnet, dass die Kapseleinheiten mittels einer oder mehrerer Lamellen zu grösseren Einheiten verbunden sind. 4. Capsule forms according to one of the claims 1-3, characterized in that the capsule units are connected to larger units by means of one or more lamellae. 5. Kapselformen nach einem der Patentansprüche 1—4, dadurch gekennzeichnet, dass der Körperteil und/oder der Kappenteil der Kapseleinheiten mit einer Lamelle verbunden ist bzw. sind. 5. Capsule shapes according to one of the claims 1-4, characterized in that the body part and / or the cap part of the capsule units is or are connected to a lamella. 6. Verfahren zur Herstellung von Kapselformen nach einem der Patentansprüche 1—5, dadurch gekennzeichnet, dass diese hergestellt werden aus einem hydrophilen Polymeren oder einer Mischung solcher Polymere mit einem Wassergehalt von 5—25% (berechnet auf die hydrophile Polymer/Wasser-Mischung), wobei für den Fall, dass die Kapselformen aus Gelatine hergestellt werden, diese einen Wassergehalt von 10—20 Gew.-% (berechnet auf die wasserhaltige Gelatine-Wasser-Mischung) aufweist. 6. Process for the production of capsule forms according to one of the claims 1-5, characterized in that they are produced from a hydrophilic polymer or a mixture of such polymers with a water content of 5-25% (calculated on the hydrophilic polymer / water mixture). In the event that the capsule forms are made from gelatin, this has a water content of 10-20% by weight (calculated on the water-containing gelatin-water mixture). 7. Verfahren zur Herstellung von Kapselformen nach einem der Patentansprüche 1—5, dadurch gekennzeichnet, dass diese aus Stärke oder einer Stärkemischung mit einem Wassergehalt von 5—25 Gew.-% (berechnet auf die wasserhaltige Stärke-Wasser-Mischung) hergestellt werden. 7. Process for the production of capsule forms according to one of the claims 1-5, characterized in that they are made from starch or a starch mixture with a water content of 5-25% by weight (calculated on the water-containing starch-water mixture). 8. Verfahren nach Patentanspruch 6 oder 7, dadurch gekennzeichnet, dass die Kapselformen mittels Spritzguss hergestellt werden. 8. The method according to claim 6 or 7, characterized in that the capsule shapes are produced by injection molding. 9. Verfahren nach Patentanspruch 6 oder 7, dadurch gekennzeichnet, dass die Kapselformen versiegelt werden. 9. The method according to claim 6 or 7, characterized in that the capsule shapes are sealed. 10. Verwendung der Kapselformen nach einem der Patentansprüche 1—5, zum genauen Dosieren von Farbstoffen, Chemikalien, Gewürzen, Düngemittelkombinationen für Pflanzen, Düngemittel mit Schutzsubstanzen, Samen, Kosmetika oder landwirtschaftlichen Produkten. 10. Use of the capsule forms according to one of claims 1-5, for precise dosing of dyes, chemicals, spices, fertilizer combinations for plants, fertilizers with protective substances, seeds, cosmetics or agricultural products. 11. Kapselformen nach einem der Patentansprüche 1 — 5, die genau dosierte Mengen an Pharmazeutika, Farbstoffen, Chemikalien, Gewürzen, Düngemittel, Samen, Kosmetika oder landwirtschaftliche Produkte enthalten. 11. Capsule forms according to one of claims 1 - 5, which contain precisely metered amounts of pharmaceuticals, dyes, chemicals, spices, fertilizers, seeds, cosmetics or agricultural products.
CH4939/84A 1983-11-04 1984-10-16 CAPSULE DOSING FORMS. CH661878A5 (en)

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US64166484A 1984-08-17 1984-08-17

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FR2554418B1 (en) 1989-11-24
GB2148841B (en) 1987-07-01
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BE900950A (en) 1985-04-30
GB2148841A (en) 1985-06-05
IT1178193B (en) 1987-09-09
IT8449110A0 (en) 1984-11-02
JPH0673539B2 (en) 1994-09-21
GB8427523D0 (en) 1984-12-05
DE3438656A1 (en) 1985-05-23

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