CA2574107A1 - Heat exchanging, optically interrogated chemical reaction assembly - Google Patents
Heat exchanging, optically interrogated chemical reaction assembly Download PDFInfo
- Publication number
- CA2574107A1 CA2574107A1 CA002574107A CA2574107A CA2574107A1 CA 2574107 A1 CA2574107 A1 CA 2574107A1 CA 002574107 A CA002574107 A CA 002574107A CA 2574107 A CA2574107 A CA 2574107A CA 2574107 A1 CA2574107 A1 CA 2574107A1
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- CA
- Canada
- Prior art keywords
- chamber
- reaction vessel
- walls
- minor
- bottom portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
An assembly for performing controlled heat exchanging reactions is provided.
The assembly has a chemical reaction chamber adapted to receive a sample and allow the sample to chemically react; a thermal sleeve having heating elements for making efficient thermal contact with a reaction chamber; an instrument with a housing comprising an electrical connection, a cooling source, a processing area adapted to receive a thermal sleeve, and an optics assembly in optical communication with a chemical reaction chamber; and a circuit for monitoring and controlling the optics assembly and for collecting the output signal of the optics assembly. Preferably there are a plurality of housings and associated modules, each of which may be independently controlled for heat exchanging operations.
The assembly has a chemical reaction chamber adapted to receive a sample and allow the sample to chemically react; a thermal sleeve having heating elements for making efficient thermal contact with a reaction chamber; an instrument with a housing comprising an electrical connection, a cooling source, a processing area adapted to receive a thermal sleeve, and an optics assembly in optical communication with a chemical reaction chamber; and a circuit for monitoring and controlling the optics assembly and for collecting the output signal of the optics assembly. Preferably there are a plurality of housings and associated modules, each of which may be independently controlled for heat exchanging operations.
Claims (13)
1. A reaction vessel for holding a sample for heat-exchanging chemical process, the reaction vessel comprising:
a) two opposing major walls;
b) a plurality of minor walls joining the major walls to each other to form a chamber having an angled bottom portion; and c) a port for introducing the sample into the chamber; wherein the ratio of the thermal conductance of the major walls to that of the minor walls is at least
a) two opposing major walls;
b) a plurality of minor walls joining the major walls to each other to form a chamber having an angled bottom portion; and c) a port for introducing the sample into the chamber; wherein the ratio of the thermal conductance of the major walls to that of the minor walls is at least
2:1, and wherein the minor walls forming the angled bottom portion of the chamber are optically transmissive to permit optical excitation of the sample through a first one of the minor walls and optical detection through a second one of the minor walls.
2. The vessel of claim 1, wherein the walls are offset about 90° from each other.
2. The vessel of claim 1, wherein the walls are offset about 90° from each other.
3. The vessel of claim 1 or 2, wherein a portion of the frame defining the chamber includes retro-reflective walls for reflecting light transmitted from the chamber.
4. The vessel of claim 3, wherein the chamber is substantially diamondshaped, and wherein the optically transmissive walls define the bottom portion of the chamber and the retro-reflective walls define the top portion of the chamber.
5. The reaction vessel of Claim 1 wherein the minor walls forming the bottom portion of the chamber are angularly offset about 90° from each other.
6. The reaction vessel of Claim 1 wherein the bottom portion of the chamber is V-shaped.
7. The reaction vessel of Claim 1 further comprising an optical element on at least one of the minor walls forming the bottom portion of the chamber.
8. The reaction vessel of Claim 7 wherein the optical element comprises a lens molded into the surface of the minor wall.
9. The reaction vessel of Claim 7 wherein each of the minor walls forming the bottom portion of the chamber has at least one lens molded into its surface.
10. The reaction vessel of Claim 1 wherein the minor walls forming a top portion of the chamber are provided by a separate piece inserted into a main body of the reaction vessel.
11. The reaction vessel of Claim 10 wherein the inserted piece further defines the port and a channel connecting the port to the chamber.
12. A method for fabricating a reaction vessel, the method comprising the steps of:
a) molding a rigid frame, wherein the frame defines the perimeter of a reaction chamber, a port, and a channel connecting the port to the chamber; and b) sealing first and second thin, flexible structures to opposite sides of the rigid frame to form the sidewalk of the chamber.
a) molding a rigid frame, wherein the frame defines the perimeter of a reaction chamber, a port, and a channel connecting the port to the chamber; and b) sealing first and second thin, flexible structures to opposite sides of the rigid frame to form the sidewalk of the chamber.
13. The method of claim 12, further comprising the step of molding a cap for sealing the port, wherein the cap includes a portion which may be inserted into the channel to pressurize the chamber, thereby expanding the sidewalls.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80832797A | 1997-02-28 | 1997-02-28 | |
US80873397A | 1997-02-28 | 1997-02-28 | |
US08/808,325 | 1997-02-28 | ||
US08/808,327 | 1997-02-28 | ||
US08/808,733 | 1997-02-28 | ||
US08/808,325 US5958349A (en) | 1997-02-28 | 1997-02-28 | Reaction vessel for heat-exchanging chemical processes |
CA002282623A CA2282623C (en) | 1997-02-28 | 1998-03-02 | Heat exchanging, optically interrogated chemical reaction assembly |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002282623A Division CA2282623C (en) | 1997-02-28 | 1998-03-02 | Heat exchanging, optically interrogated chemical reaction assembly |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2574107A1 true CA2574107A1 (en) | 1998-09-03 |
CA2574107C CA2574107C (en) | 2011-08-16 |
Family
ID=37872145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2574107A Expired - Lifetime CA2574107C (en) | 1997-02-28 | 1998-03-02 | Heat exchanging, optically interrogated chemical reaction assembly |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2574107C (en) |
Cited By (16)
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US10604788B2 (en) | 2004-05-03 | 2020-03-31 | Handylab, Inc. | System for processing polynucleotide-containing samples |
US10619191B2 (en) | 2001-03-28 | 2020-04-14 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10625262B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10731201B2 (en) | 2003-07-31 | 2020-08-04 | Handylab, Inc. | Processing particle-containing samples |
US10781482B2 (en) | 2011-04-15 | 2020-09-22 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US10799862B2 (en) | 2006-03-24 | 2020-10-13 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
US10821446B1 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10844368B2 (en) | 2007-07-13 | 2020-11-24 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11060082B2 (en) | 2007-07-13 | 2021-07-13 | Handy Lab, Inc. | Polynucleotide capture materials, and systems using same |
US11142785B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US11266987B2 (en) | 2007-07-13 | 2022-03-08 | Handylab, Inc. | Microfluidic cartridge |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US11549959B2 (en) | 2007-07-13 | 2023-01-10 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
-
1998
- 1998-03-02 CA CA2574107A patent/CA2574107C/en not_active Expired - Lifetime
Cited By (34)
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US10619191B2 (en) | 2001-03-28 | 2020-04-14 | Handylab, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US10731201B2 (en) | 2003-07-31 | 2020-08-04 | Handylab, Inc. | Processing particle-containing samples |
US10865437B2 (en) | 2003-07-31 | 2020-12-15 | Handylab, Inc. | Processing particle-containing samples |
US11078523B2 (en) | 2003-07-31 | 2021-08-03 | Handylab, Inc. | Processing particle-containing samples |
US10604788B2 (en) | 2004-05-03 | 2020-03-31 | Handylab, Inc. | System for processing polynucleotide-containing samples |
US11441171B2 (en) | 2004-05-03 | 2022-09-13 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US10799862B2 (en) | 2006-03-24 | 2020-10-13 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US11141734B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11666903B2 (en) | 2006-03-24 | 2023-06-06 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US10821436B2 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11142785B2 (en) | 2006-03-24 | 2021-10-12 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10821446B1 (en) | 2006-03-24 | 2020-11-03 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10843188B2 (en) | 2006-03-24 | 2020-11-24 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US11085069B2 (en) | 2006-03-24 | 2021-08-10 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10857535B2 (en) | 2006-03-24 | 2020-12-08 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11959126B2 (en) | 2006-03-24 | 2024-04-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10913061B2 (en) | 2006-03-24 | 2021-02-09 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
US10875022B2 (en) | 2007-07-13 | 2020-12-29 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US11549959B2 (en) | 2007-07-13 | 2023-01-10 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US10844368B2 (en) | 2007-07-13 | 2020-11-24 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US10625262B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10625261B2 (en) | 2007-07-13 | 2020-04-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US11254927B2 (en) | 2007-07-13 | 2022-02-22 | Handylab, Inc. | Polynucleotide capture materials, and systems using same |
US11266987B2 (en) | 2007-07-13 | 2022-03-08 | Handylab, Inc. | Microfluidic cartridge |
US10717085B2 (en) | 2007-07-13 | 2020-07-21 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US10632466B1 (en) | 2007-07-13 | 2020-04-28 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US11466263B2 (en) | 2007-07-13 | 2022-10-11 | Handylab, Inc. | Diagnostic apparatus to extract nucleic acids including a magnetic assembly and a heater assembly |
US11060082B2 (en) | 2007-07-13 | 2021-07-13 | Handy Lab, Inc. | Polynucleotide capture materials, and systems using same |
US11788127B2 (en) | 2011-04-15 | 2023-10-17 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US10781482B2 (en) | 2011-04-15 | 2020-09-22 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
US11453906B2 (en) | 2011-11-04 | 2022-09-27 | Handylab, Inc. | Multiplexed diagnostic detection apparatus and methods |
US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
Also Published As
Publication number | Publication date |
---|---|
CA2574107C (en) | 2011-08-16 |
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EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20180302 |