CA2512536A1 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators - Google Patents

Abstract

EGFR biomakers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal level of at least one biomaker, wherein a difference in the level in at least one biomaker measured in (b) compared to the level of the biomaker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.

Description

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BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO
EPIDERMAL GROWTH FACTOR RECEPTOR MODULATORS
FIELD OF THE INVENTION
The present invention relates generally to the field of pharmacogenomics, and more specifically to methods and procedures to determine sensitivity in patients to allow the development of individualized genetic profiles which aid in treating diseases and disorders based on patient response at a molecular level.
BACKGROUND OF THE INVENTION:
Cancer is a disease with extensive histoclinical heterogeneity. Although conventional histological and clinical features have been correlated to prognosis, the same apparent prognostic type of tumors varies widely in its responsiveness to therapy and consequent survival of the patient.
New prognostic and predictive markers, which would facilitate an individualization of therapy for each patient, are needed to accurately predict patient response to treatments, such as small molecule or biological molecule drugs, in the clinic. The problem may be solved by the identification of new parameters that could better predict the patient's sensitivity to treatment. The classification of patient samples is a crucial aspect of cancer diagnosis and treatment. The association of a patient's response to a treatment with molecular and genetic markers can open up new opportunities for treatment development in non-responding patients, or distinguish a treatment's indication among other treatment choices because of higher confidence in the efficacy. Further, the pre-selection of patients who are likely to respond well to a medicine, drug, or combination therapy may reduce the number of patients needed in a clinical study or accelerate the time needed to complete a clinical development program (M. Cockett et al., 2000, Current Opinion ifz Biotechnology, 11:602-609).
The ability to predict drug sensitivity in patients is particularly challenging because drug responses reflect not only properties intrinsic to the target cells, but also a host's metabolic properties. Efforts to use genetic information to predict drug sensitivity have primarily focused on individual genes that have broad effects, such as the multidrug resistance genes, ~2drl and fnfpl (P. Sonneveld, 2000, J.
Intef°n. Med., 247:521-534).

The development of microarray technologies for large scale characterization of gene mRNA expression pattern has made it possible to systematically search for molecular markers and to categorize cancers into distinct subgroups not evident by traditional histopathological methods (J. Khan et al., 1998, Cancer Res., 58:5009-5013; A.A. Alizadeh et al., 2000, Natui°e, 403:503-511; M. Bittner et al., 2000, Nature, 406:536-540; J. Khan et al., 2001, Nature Medicine, 7(6):673-679; and T.R.
Golub et al., 1999, Science, 286:531-537; U. Alon et al., 1999, Proc. Natl.
Acad. Sci.
USA, 96:6745-6750). Such technologies and molecular tools have made it possible to monitor the expression level of a large number of transcripts within a cell population at any given time (see, e.g., Schena et al., 1995, Science, 270:467-470;
Lockhart et al., 1996 Nature Biotechnology, 14:1675-1680; Blanchard et al., 1996, Natuf°e Biotechnology, 14:1649; U.S. Patent No. 5,569,588 to Ashby et al.).
Recent studies demonstrate that gene expression information generated by microarray analysis of human tumors can predict clinical outcome (L.J. van't Veer et al., 2002, Nature, 415:530-536; M. West et al., 2001, Proc. Natl. Acad. Sci.
USA, 98:11462-11467; T. Sorlie et al., 2001, Proc. Natl. Acad. Sci. USA, 98:10869-10874;
M. Shipp et al., 2002, Nature Medicine, 8(1):68-74). These findings bring hope that cancer treatment will be vastly improved by better predicting the response of individual tumors to therapy.
Needed are new and alternative methods and procedures to determine drug sensitivity in patients to allow the development of individualized genetic profiles which are necessary to treat diseases and disorders based on patient response at a molecular level.
SUMMARY OF THE INVENTION:
The invention provides methods and procedures for determining patient sensitivity to one or more Epidermal Growth Factor Receptor (EGFR) modulators.
The invention also provides methods of determining or predicting whether an individual requiring therapy for a disease state such as cancer will or will not respond to treatment, prior to administration of the treatment, wherein the treatment comprises one or more EGFR modulators. The one or more EGFR modulators are compounds that can be selected from, for example, one or more EGFR specific ligands, one or _2_ more small molecule EGFR inhibitors, or one or more EGFR binding monoclonal antibodies.
In one aspect, the invention provides a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 4;
(b) exposing the mammal to the EGFR modulator; (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer.
As used herein, respond therapeutically refers to the alleviation or abrogation of the cancer. This means that the life expectancy of an individual affected with the cancer will be increased or that one or more of the symptoms of the cancer will be reduced or ameliorated. The term encompasses a reduction in cancerous cell growth or tumor volume. Whether a mammal responds therapeutically can be measured by many methods well known in the art, such as PET imaging.
The at least one biomarker can also be selected from the biomarkers of Table 5. The mammal can be, for example, a human, rat, mouse, dog rabbit, pig sheep, cow, horse, cat, primate, or monkey.
The method of the invention can be, for example, an in vitro method and wherein the at least one biornarker is measured in at least one mammalian biological sample from the mammal. The biological sample can comprise, for example, at least one of whole fresh blood, peripheral blood mononuclear cells, frozen whole blood, fresh plasma, frozen plasma, urine, saliva, skin, hair follicle, or tumor tissue.
In another aspect, the invention provides a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises: (a) exposing the mammal to the EGFR modulator; (b) following the exposing of step (a), measuring in the mammal the level of the at least one biomarker selected from the biomarkers of Table 4, wherein a difference in the level of the at least one biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said EGFR modulator, indicates that the mammal will respond therapeutically to said method of treating cancer.
In yet another aspect, the invention provides a method for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 4; (b) exposing the mammal to the EGFR modulator; (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer.
In another aspect, the invention provides a method for determining whether a compound inhibits EGFR activity in a mammal, comprising: (a) exposing the mammal to the compound; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 4, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said compound, indicates that the compound inhibits EGFR activity in the mammal.
In yet another aspect, the invention provides a method for determining whether a mammal has been exposed to a compound that inhibits EGFR activity, comprising (a) exposing the mammal to the compound; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 4, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said compound, indicates that the mammal has been exposed to a compound that inhibits EGFR activity.
In another aspect, the invention provides a method for determining whether a mammal is responding to a compound that inhibits EGFR activity, comprising (a) exposing the mammal to the compound; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomaxkers of Table 4, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said compound, indicates that the mammal is responding to the compound that inhibits EGFR activity.
As used herein, "responding" encompasses responding by way of a biological and cellular response, as well as a clinical response (such as improved symptoms, a therapeutic effect, or an adverse event), in a mammal The invention also provides an isolated biomarker selected from the biomarkers of Table 4. The biomarkers of the invention comprise sequences selected from the nucleotide and amino acid sequences provided in Table 4 and the Sequence Listing, as well as fragments and variants thereof.
The invention also provides a biomarker set comprising two or more biomarkers selected from the biomarkers of Table 4.
The invention also provides kits for determining or predicting whether a patient would be susceptible or resistant to a treatment that comprises one or more EGFR modulators. The patient may have a cancer or tumor such as, for example, a colon cancer or tumor.
In one aspect, the kit comprises a suitable container that comprises one or more specialized microarrays of the invention, one or more EGFR modulators for use in testing cells from patient tissue specimens or patient samples, and instructions for use. The kit may further comprise reagents or materials for monitoring the expression of a biomarker set at the level of mRNA or protein.
In another aspect, the invention provides a kit comprising two or more biomarkers selected from the biomarkers of Table 4.
In yet another aspect, the invention provides a kit comprising at least one of an antibody and a nucleic acid for detecting the presence of at least one of the biomarkers selected from the biomarkers of Table 4. In one aspect, the kit further comprises instructions for determining whether or not a mammal will respond therapeutically to a method of treating cancer comprising administering a compound that inhibits EGFR activity. In another aspect, the instructions comprise the steps of (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 4, (b) exposing the mammal to the compound, (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, _5_ wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer.
The invention also provides screening assays for determining if a patient will be susceptible or resistant to treatment with one or more EGFR modulators.
The invention also provides a method of monitoring the treatment of a patient having a disease treatable by one or more EGFR modulators.
The invention also provides individualized genetic profiles which are necessary to treat diseases and disorders based on patient response at a molecular level.
The invention also provides specialized microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, comprising one or more biomarkers having expression profiles that correlate with either sensitivity or resistance to one or more EGFR modulators.
The invention also provides antibodies, including polyclonal or monoclonal, directed against one or more biomarkers of the invention.
The invention will be better understood upon a reading of the detailed description of the invention when considered in connection with the accompanying figures.
BRIEF DESCRIPTION OF THE FIGURES:
FIG. 1 illustrates a EGFR biomarker identification and prioritization strategy.
FIG. 2A illustrates the RT-PCR results for EGFR in thirty one colon cancer cell lines to identify cell lines which do not have significant mRNA
expression of EGFR.
FIG. 2B illustrates the ICSO profile for twenty two colon cancer cell lines with an EGFR inhibitor compound, and determination of sensitive and resistant cell lines.

DETAILED DESCRIPTION OF THE INVENTION:
The invention provides biomarkers that respond to the modulation of a specific signal transduction pathway and also correlate with EGFR modulator sensitivity or resistance. These biomarkers can be employed for predicting response to one or more EGFR modulators. In one aspect, the biomarkers of the invention are those provided in Table 4 and the Sequence Listing, including both polynucleotide and polypeptide sequences.
The biomarkers were determined by an in vit~°o assay employing microarray technology to monitor simultaneously the expression pattern of thousands of discrete genes in untreated cells, whose response to the modulation of a signal transduction pathway, in particular the EGFR pathway, was tested on untreated cells whose sensitivity to EGFR modulators was tested. The biomarkers have expression levels in the cells that are dependent on the activity of the EFGR signal transduction pathway and that are also highly correlated with EGFR modulator sensitivity exhibited by the cells. Biomarkers serve as useful molecular tools for predicting a response to EGFR
modulators, preferably biological molecules, small molecules, and the like that affect EGFR kinase activity via direct or indirect inhibition or antagonism of EGFR
kinase function or activity.
EGFR MODULATORS
As used herein, the term "EGFR modulator" is intended to mean a compound or drug that is a biological molecule or a small molecule that directly or indirectly modulates EGFR activity or the EGFR signal transduction pathway. Thus, compounds or drugs as used herein is intended to include both small molecules and biological molecules. Direct or indirect modulation includes activation or inhibition of EGFR activity or the EGFR signal transduction pathway. In one aspect, inhibition refers to inhibition of the binding of EGFR to an EGFR ligand such as, for example, EGF. In another aspect, inhibition refers to inhibition of the kinase activity of EGFR.
EGFR modulators include, for example, EGFR specific ligands, small molecule EGFR inhibitors, and EGFR monoclonal antibodies.. In one aspect, the EGFR modulator inhibits EGFR activity and/or inhibits the EGFR signal transduction 7_ pathway. Tn another aspect, the EGFR modulator is an EGFR antibody that inhibits EGFR activity and/or inhibits the EGFR signal transduction pathway.
EGFR modulators include biological molecules or small molecules.
Biological molecules include all lipids and polymers of monosaccharides, amino acids, and nucleotides having a molecular weight greater than 450. Thus, biological molecules include, for example, oligosaccharides and polysaccharides;
oligopeptides, polypeptides, peptides, and proteins; and oligonucleotides and polynucleotides.
Oligonucleotides and polynucleotides include, for example, DNA and RNA.
Biological molecules further include derivatives of any of the molecules described above. For example, derivatives of biological molecules include lipid and glycosylation derivatives of oligopeptides, polypeptides, peptides, and proteins.
Derivatives of biological molecules further include lipid derivatives of oligosaccharides and polysaccharides, e.g., lipopolysaccharides. Most typically, biological molecules are antibodies, or functional equivalents of antibodies.
Functional equivalents of antibodies have binding characteristics comparable to those of antibodies, and inhibit the growth of cells that express EGFR. Such functional equivalents include, for example, chimerized, humanized, and single chain antibodies as well as fragments thereof.
Functional equivalents of antibodies also include polypeptides with amino acid sequences substantially the same as the amino acid sequence of the variable or hypervariable regions of the antibodies. An amino acid sequence that is substantially the same as another sequence, but that differs from the other sequence by means of one or more substitutions, additions, and/or deletions, is considered to be an equivalent sequence. Preferably, less than 50%, more preferably less than 25%, and still more preferably less than 10%, of the number of amino acid residues in a sequence are substituted for, added to, or deleted from the protein.
The functional equivalent of an antibody is preferably a chimerized or humanized antibody. A chimerized antibody comprises the variable region of a non-human antibody and the constant region of a human antibody. A humanized antibody comprises the hypervariable region (CDRs) of a non-human antibody. The variable region other than the hypervariable region, e.g., the framework variable region, and the constant region of a humanized antibody are those of a human antibody.
_g_ Suitable variable and hypervariable regions of non-human antibodies may be derived from antibodies produced by any non-human mammal in which monoclonal antibodies are made. Suitable examples of mammals other than humans include, for example, rabbits, rats, mice, horses, goats, or primates.
Functional equivalents further include fragments of antibodies that have binding characteristics that are the same as, or are comparable to, those of the whole antibody. Suitable fragments of the antibody include any fragment that comprises a sufficient portion of the hypervariable (i.e., complementarity determining) region to bind specifically, and with sufficient affinity, to EGFR tyrosine kinase to inhibit growth of cells that express such receptors.
Such fragments may, for example, contain one or both Fab fragments or the F(ab')2 fragment. Preferably, the antibody fragments contain all six complementarity determining regions of the whole antibody, although functional fragments containing fewer than all of such regions, such as three, four, or five CDRs, are also included.
In one aspect, the fragments are single chain antibodies, or Fv fragments.
Single chain antibodies are polypeptides that comprise at least the variable region of the heavy chain of the antibody linked to the vaxiable region of the light chain, with or without an interconnecting linker. Thus, Fv fragment comprises the entire antibody combining site. These chains may be produced in bacteria or in eukaryotic cells.
The antibodies and functional equivalents may be members of any class of immunoglobulins, such as IgG, IgM, IgA, IgD, or IgE, and the subclasses thereof.
In one aspect, the antibodies are members of the IgGl subclass. The functional equivalents may also be equivalents of combinations of any of the above classes and subclasses.
In one aspect, EGFR antibodies can be selected from chimerized, humanized, fully human, and single chain antibodies derived from the marine antibody 225 described in U.S. Patent No. 4,943,533 to Mendelsohn et al. In one aspect, the derived antibodies have the following hypervariable (CDR) regions of the light and heavy chain, wherein the amino acid sequences are indicated below the nucleotide sequences:
HEAVY CHAIN HYPERVARIABLE REGIONS (VH):

CDRl AACTATGGTGTACAC (SEQ ID NO: 179) N Y G V H (SEQ ID NO: 180) GTGATATGGAGTGGTGGAAACACAGACTATAATACACCTTTCACATCC
(SEQ ID NO: 181) VIWSGGNTDYNTPFTS(SEQIDN0:182) GCCCTCACCTACTATGATTACGAGTTTGCTTAC (SEQ ID NO: 183) ALTYYDYEFAY(SEQIDN0:184) LIGHT CHAIN HYPERVARIABLE REGIONS (VL):
CDRl AGGGCCAGTCAGAGTATTGGCACAAACATACAC (SEQ ID NO: 185) RASQSIGTNIH(SEQIDN0:186) GCTTCTGAGTCTATCTCT (SEQ ID NO: 187) A S E S I S (SEQ ID NO: 188) CAACAAAATAATAACTGGCCAACCACG (SEQ ID NO: 189) Q Q N N N W P T T (SEQ ID NO: 190) In another aspect, the EGFR antibody can be selected from the antibodies described in U.S. Patent No. 6,235,883 to Jakobovits et al., U.S. Patent No. 5,558,864 to Bendi et al., and U.S. Patent No. 5,891,996 to Mateo de Acosta del Rio et al.
In addition to the biological molecules discussed above, the EGFR modulators useful in the invention may also be small molecules. Any molecule that is not a biological molecule is considered herein to be a small molecule. Some examples of small molecules include organic compounds, organometallic compounds, salts of organic and organometallic compounds, saccharides, amino acids, and nucleotides.
Small molecules further include molecules that would otherwise be considered biological molecules, except their molecular weight is not greater than 450.
Thus, small molecules may be lipids, oligosaccharides, oligopeptides, and oligonucleotides and their derivatives, having a molecular weight of 450 or less.
It is emphasized that small molecules can have any molecular weight. They are merely called small molecules because they typically have molecular weights less than 450. Small molecules include compounds that are found in nature as well as synthetic compounds. In one embodiment, the EGFR modulator is a small molecule that inhibits the growth of tumor cells that express EGFR. In another embodiment, the EGFR modulator is a small molecule that inhibits the growth of refractory tumor cells that express EGFR.
Numerous small molecules have been described as being useful to inhibit EGFR. For example, U.S. Patent No. 5,656,655 to Spada et al. discloses styryl substituted heteroaryl compounds that inhibit EGFR. The heteroaryl group is a monocyclic ring with one or two heteroatoms, or a bicyclic ring with 1 to about 4 heteroatoms, the compound being optionally substituted or polysubstituted.
U.S. Patent No. 5,646,153 to Spada et al. discloses bis mono and/or bicyclic aryl heteroaryl, carbocyclic, and heterocarbocyclic compounds that inhibit EGFR.
U.S. Patent No. 5,679,683 to Bridges et al. discloses tricyclic pyrimidine compounds that inhibit the EGFR. The compounds are fused heterocyclic pyrimidine derivatives described at column 3, line 35 to column 5, line 6.
U.S. Patent No. 5,616,582 to Barker discloses quinazoline derivatives that have receptor tyrosine kinase inhibitory activity.
Fry et al., Science 265, 1093-1095 (1994) in Figure 1 discloses a compound having a structure that inhibits EGFR.
Osherov et al. disclose tyrphostins that inhibit EGFR/HERl and HER 2, particularly those in Tables I, II, III, and IV.
U.S. Patent No. 5,196,446 to Levitzki et al. discloses heteroarylethenediyl or heteroarylethendeiylaryl compounds that inhibit EGFR, particularly from column 2, line 42 to column 3, line 40.
Panek et al., Journal of Pharmacology and Experimental Therapeutics 283, 1433-1444 (1997) discloses a compound identified as PD166285 that inhibits the EGFR, PDGFR, and FGFR families of receptors. PD166285 is identified as 6-(2,6-dichlorophenyl)-2-(4-(2-diethylamirioethyoxy)phenylamino)-8-methyl-8H-pyrido(2,3-d)pyrimidin-7-one having the structure shown in Figure 1 on page 1436.
BIOMARI~ERS AND BIOMARI~ER SETS
The invention includes individual biomarkers and biomarker sets having both diagnostic and prognostic value in disease areas in which signaling through EGFR or the EGFR pathway is of importance, e.g., in cancers or tumors, in ixnmunological disorders, conditions or dysfunction, or in disease states in which cell signaling and/or cellular proliferation controls are abnormal or aberrant. The biomarker sets comprise a plurality of biomarkers such as, for example, a plurality of the biomarkers provided in Table 4 below, that highly correlate with resistance or sensitivity to one or more EGFR modulators.
The biomarker sets of the invention enable one to predict or reasonably foretell the likely effect of one or more EGFR modulators in different biological systems or for cellular responses. The biomarker sets can be used in i~ vitro assays of EGFR modulator response by test cells to predict ifs vivo outcome. In accordance with the invention, the various biomarker sets described herein, or the combination of these biomarker sets with other biomarkers or markers, can be used, for example, to predict how patients with cancer might respond to therapeutic intervention with one or more EGFR modulators.
A biomarker set of cellular gene expression patterns correlating with sensitivity or resistance of cells following exposure of the cells to one or more EGFR
modulators provides a useful tool for screening one or tumor samples before treatment with the EGFR modulator. The screening allows a prediction of cells of a tumor sample exposed to one or more EGFR modulators, based on the expression results of the biomarker set, as to whether or not the tumor, and hence a patient harboring the ' tumor, will or will not respond to treatment with the EGFR modulator.
The biomarker or biomarker set can also be used as described herein for monitoring the progress of disease treatment or therapy in those patients undergoing treatment for a disease involving an EGFR modulator.
The biomarkers serve as targets for the development of therapies for disease treatment. Such targets may be particularly applicable to treatment of breast disease, such as breast cancers or tumors. Indeed, because these biomarkers are differentially expressed in sensitive and resistant cells, their expression patterns are correlated with relative intrinsic sensitivity of cells to treatment with EGFR modulators.
Accordingly, the biomarkers highly expressed in resistant cells may serve as targets for the development of new therapies for the tumors which are resistant to EGFR
modulators, particularly EGFR inhibitors.
MICROARRAYS
The invention also includes specialized microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, comprising one or more biomarkers, showing expression profiles that correlate with either sensitivity or resistance to one or more EGFR modulators. Such microarrays can be employed in in vitro assays for assessing the expression level of the biomarkers in the test cells from tumor biopsies, and determining whether these test cells are likely to be resistant or sensitive to EGFR
modulators. For example, a specialized microarray can be prepared using all the biomarkers, or subsets thereof, as described herein and shown in Table 4.
Cells from a tissue or organ biopsy can be isolated and exposed to one or more of the EGFR
modulators. Following application of nucleic acids isolated from both untreated and treated cells to one or more of the specialized microarrays, the pattern of gene expression of the tested cells can be determined and compared with that of the biomarker pattern from the control panel of cells used to create the biomarker set on the microarray. Based upon the gene expression pattern results from the cells that underwent testing, it can be determined if the cells show a resistant or a sensitive profile of gene expression. Whether or not the tested cells from a tissue or organ biopsy will respond to one or more of the EGFR modulators and the course of treatment or therapy can then be determined or evaluated based on the information gleaned from the results of the specialized microarray analysis.
ANTIBODIES
The invention also includes antibodies, including polyclonal or monoclonal, directed against one or more of the polypeptide biomarkers. Such antibodies can be used in a variety of ways, for example, to purify, detect, and target the biomarkers of the invention, including both i~ vitro and ih vivo diagnostic, detection, screening, andlor therapeutic methods.
FITS
The invention also includes kits for determining or predicting whether a patient would be susceptible or resistant to a treatment that comprises one or more EGFR modulators. The patient may have a cancer or tumor such as, for example, a breast cancer or tumor. Such kits would be useful in a clinical setting for use in testing a patient's biopsied tumor or cancer samples, for example, to determine or predict if the patient's tumor or cancer will be resistant or sensitive to a given treatment or therapy with an EGFR modulator. The kit comprises a suitable container that comprises: one or more microarrays, e.g., oligonucleotide microarrays or cDNA
microarrays, that comprise those biomarkers that correlate with resistance and sensitivity to EGFR modulators, particularly EGFR inhibitors; one or more EGFR
modulators for use in testing cells from patient tissue specimens or patient samples;
and instructions for use. In addition, kits contemplated by the invention can further include, for example, reagents or materials for monitoring the expression of biomarkers of the invention at the level of mRNA or protein, using other techniques and systems practiced in the art such as, for example, RT-PCR assays, which employ primers designed on the basis of one or more of the biomarkers described herein, immunoassays, such as enzyme linked immunosorbent assays (ELISAs), immunoblotting, e.g., Western blots, or ifz situ hybridization, and the like, as further described herein.
APPLICATION OF BIOMARI~ERS AND BIOMARI~ER SETS
The biomarkers and biomarker sets may be used in different applications.
Biomarker sets can be built from any combination of biomarkers listed in Table 4 to make predictions about the likely effect of any EGFR modulator in different biological systems. The various biomarkers and biomarker sets described herein can be used, for example, as diagnostic or prognostic indicators in disease management, to predict how patients with cancer might respond to therapeutic intervention with compounds that modulate the EGFR, and to predict how patients might respond to therapeutic intervention that modulates signaling through the entire EGFR
regulatory pathway.
While the data described herein were generated in cell lines that are routinely used to screen and identify compounds that have potential utility for cancer therapy, the biomarkers have both diagnostic and prognostic value in other diseases areas in which signaling through EGFR or the EGFR pathway is of importance, e.g., in immunology, or in cancers or tumors in which cell signaling and/or proliferation controls have gone awry.
In the examples described below, the sensitivity and resistance classifications in the twenty two colon cell lines were similar for the two EGFR modulators tested.
Therefore, the biomarkers of the invention are expected to have both diagnostic and prognostic value for other compounds that modulate EGFR or the EGFR signaling pathways.
Those having skill in the pertinent art will appreciate that the EGFR
signaling pathway is used and functional in cell types other than cell lines of colon tissue.
Therefore, the described biomarkers are expected to have utility for predicting drug sensitivity or resistance to compounds that interact with or inhibit the EGFR
activity in cells from other tissues or organs associated with a disease state, or cancers or tumors derived from other tissue types. Non-limiting examples of such cells, tissues and organs include breast, colon, lung, prostate, testes, ovaries, cervix, esophagus, pancreas, spleen, liver, kidney, stomach, lymphocytic and brain, thereby providing a broad and advantageous applicability to the biomarkers described herein. Cells for analysis can be obtained by conventional procedures as known in the art, for example, tissue biopsy, aspiration, sloughed cells, e.g., colonocytes, clinical or.medical tissue or cell sampling procedures.
In accordance with the invention, cells from a patient tissue sample, e.g., a tumor or cancer biopsy, can be assayed to determine the expression pattern of one or more biomarkers prior to treatment with one or more EGFR modulators. Success or failure of a treatment can be determined based on the biomaxker expression pattern of the cells from the test tissue (test cells), e.g., tumor or cancer biopsy, as being relatively similar or different from the expression pattern of a control set of the one or more biomarkers. Thus, if the test cells show a biomarker expression profile which corresponds to that of the biomarkers in the control panel of cells which are sensitive to the EGFR modulator, it is highly likely or predicted that the individual's cancer or tumor will respond favorably to treatment with the EGFR modulator. By contrast, if the test cells show a biomarker expression pattern corresponding to that of the biomarkers of the control panel of cells which are resistant to the EGFR
modulator, it is highly likely or predicted that the individual's cancer or tumor will not respond to treatment with the EGFR modulator.
The invention also provides a method of monitoring the treatment of a patient having a disease treatable by one or more EGFR modulators. The isolated test cells from the patient's tissue sample, e.g., a tumor biopsy or tumor sample, can be assayed to determine the expression pattern of one or more biomarkers before and after exposure to an EGFR modulator wherein, preferably, the EGFR modulator is an EGFR inhibitor. The resulting biomarker expression profile of the test cells before and after treatment is compared with that of one or more biomarkers as described and shown herein to be highly expressed in the control panel of cells that are either resistant or sensitive to an EGFR modulator. Thus, if a patient's response is sensitive to treatment by an EGFR modulator, based on correlation of the expression profile of the one or biomarkers, the patient's treatment prognosis can be qualified as favorable and treatment can continue. Also, if, after treatment with an EGFR modulator, the test cells don't show a change in the biomarker expression profile corresponding to the control panel of cells that are sensitive to the EGFR modulator, it can serve as an indicator that the current treatment should be modified, changed, or even discontinued. Tlus monitoring process can indicate success or failure of a patient's treatment with an EGFR modulator and such monitoring processes can be repeated as necessary or desired.
The biomarkers of the invention can be used to predict an outcome prior to having any knowledge about a biological system. Essentially, a biomarker can be considered to be a statistical tool. Biomarkers are useful primarily in predicting the phenotype that is used to classify the biological system. In an embodiment of the invention, the goal of the prediction is to classify cancer cells as having an active or inactive EGFR pathway. Cancer cells with an inactive EGFR pathway can be considered resistant to treatment with an EGFR modulator. An inactive EGFR

pathway is defined herein as a non-significant expression of the EGFR or by a classification as "resistant" or "sensitive" based on the ICSO value of each colon cell line to a compound (EGFR inhibitor compound BMS-461453) exemplified herein.
A number of the biomarker described herein are known to be regulated by EGFR, e.g., mucin 2 (J Biol Chem. 2002 Aug 30;277(35):32258-67). Another biomarker, betacellulin, is know to be an EGFR ligand (Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6). A functional relationship of the top biomarkers to the EGFR is expected, since biomarkers that contribute to high biomarker accuracy are likely to play a functional role in the pathway that is being modulated. For example, Perception therapy (i.e., antibody that binds to the Her2 receptor and prevents function via internalization) is indicated when the Her2 gene is overexpressed. It is unlikely that a therapy will have any therapeutic effect if the target enzyme is not expressed.
However, although the complete function of all of the biomarkers are not currently known, some of the biomarkers are likely to be directly or indirectly involved in the EGFR signaling pathway. In addition, some of the biomarkers may function in the metabolic or other resistance pathways specific to the EGFR
modulators tested. Notwithstanding, knowledge about the function of the biomarkers is not a requisite for determining the accuracy of a biomarker according to the practice of the invention.
DISCOVERY OF BIOMARKERS
An approach has been discovered in which biomarkers were identified whose expression patterns, in a subset of cell lines, correlated to and can be used as an ih vitro marker of cellular response to treatment or therapy with one compound, or with a combination or series of compounds, that are known to inhibit or activate the function of a protein, enzyme, or molecule (e.g., a receptor) that is directly or indirectly involved in cell proliferation, cell responses to external stimuli, (such as ligand binding), or signal transduction, e.g., a receptor tyrosine kinase.
Preferred are antagonists or inhibitors of the function of a given protein, e.g., a receptor tyrosine kinase.

Two analytical strategies were deployed to discover biomarkers useful for predicting the sensitivity or resistance of cancer cells to treatment with one or more EGFR modulators. FIG. 1 illustrates the EGFR biomarker identification and prioritization strategy. In one strategy, the mRNA expression level of EGFR
was used to identify six colon cancer cell lines with, inferred from the mRNA
expression level, no significant presence of the EGFR protein and hence no significant activity of the EGFR pathway (FIG. 2A). In subsequent analyses, biomarkers were identified that had no significant mRNA expression level in the six cell lines and no inferred presence of the EGFR protein. Further, it was required that these biomarkers would have a significant mRNA expression level in at least six other cell lines.
In a second strategy, an EGFR specific tyrosine kinase inhibitor compound was used to determine compound sensitivity in a panel of twenty two colon cancer cell lines following exposure of the cells to the compound. Some of the cell lines were determined to be resistant to treatment with the inhibitor compound, while others were determined to be sensitive to the inhibitor (FIG. 2B). A subset of the cell lines examined provided an expression pattern or profile of biomarkers that correlated to a response by the cells to the EGFR inhibitor compound as well as the absence of significant EGFR expression as thus could serve as biomarkers.
By combining the use of EGFR co-regulation studies in tumor cells with experimental studies in cultured cells as a model of i~ vivo effects, the invention advantageously focuses on cell-intrinsic properties that are exposed in cell culture to identify biomarkers that predict compound sensitivity and resistance. The discovery and identification of biomaxkers in tumor cells and cell lines assayed i~
vitr°o can be used to predict responses to one or more EGFR modulators i~ vivo and, thus, can be extended to clinical situations in which the same biomarkers axe used to predict patients' responses to one or more EGFR modulators and treatments comprising one or more EGFR modulators.
As described in the examples below, oligonucleotide microarrays were used to measure the expression levels of over 44,792 probe sets in a panel of thirty one untreated colon cancer cell lines for which the expression status of the EGFR
and the drug sensitivity to EGFR inhibitor compounds was determined. This analysis was performed to determine whether the gene expression signatures of untreated cells -l~-were sufficient for the prediction of sensitivity of the disease to inhibition of the EGFR by small molecule or biological molecule compounds. Through data analysis, biomarkers were identified whose expression levels were found to be highly counter-correlated with the status of the EGFR and correlated with the drug sensitivity. In addition, the treatment of cells with a small molecule EGFR inhibitor also provided gene expression signatures predictive of sensitivity to the compound.
The means of performing the gene expression and biomarker identification analyses embraced by the invention is described in further detail and without limitation below.
ICSO Determination and Phenotype Classification Based on Sensitivity of Twenty-two Colon Cancer Cell lines to EGFR Inhibitor Compounds Twenty two colon cell lines were treated with a small molecule EGFR
inhibitor (BMS-461453) to determine the individual ICSO value. The ICSO for each cell line was assessed by MTS assays. The average ICSO values along with standard deviations were calculated from two to five individual determinations for each cell line. As shown in FIG. 2B, a 4-fold variation in the ICSO values was observed for the small molecule EGFR inhibitor among the 22 colon cancer cell lines. The ICSO
unit is ~M.
All cell lines with at least a 1.75 fold lower ICSO than the most resistant cell lines were considered to be sensitive to treatment with the small molecule EGFR
inhibitor. FIG. 2B represents the resistance/sensitivity classifications of the twenty-two colon cell lines to the small molecule EGFR inhibitor. Five cell lines were classified as sensitive and seventeen cell lines as resistant.
Description of the Strategy for Identifying Biomarkers Biomarkers were discovered based on two criteria: (i) the correlation of their mRNA expression level to the expression of EGFR in cell lines with insignificant EGFR expression and (ii) the correlation of the ICSO values for the small molecule EGFR inhibitor BMS-461453 with gene expression levels.
For each of these two biomarker selection strategies, two independent "discovery" probe set lists were established by using statistical filters with different stringency levels to identify genes whose expression correlated with either EGFR
status or ICSO value. These statistical methods are described below and resulted in four discovery probe set lists: EGFR-A and EGFR-B (correlation with no significant EGFR expression) and IC-50-A, IC-50-B (correlation with ICSO expression), the A-lists containing probe sets selected by more stringent conditions. To then establish two biomarker probe set lists, probe sets that appeared in both EGFR-A and IC-were selected (Biomarker Probe Set List A, Table 2) and probe sets that appeared in both EGFR-B and IC-50-A were selected (Biomarker Probe Set List B, Table 3).
Identifying Genes that Significantly Correlate with EGFR status classification RT-PCR expression data for EGFR were obtained from thirty one colon cancer cell lines and six cell lines with a significantly lower expression level of EGFR
compared to the other cell lines were identified as described in Example 1 below.
(FIG. 2A). Expression profiling data of 44,792 probe sets represented on the HG-U133 array set for all thirty one untreated colon cancer cell lines were obtained and analyzed for the identification of probe sets which would be correlated with the above described six cell lines with no significant mRNA expression of EGFR. For the discovery probe set list EGFR-A, all probe sets which were judged to be absent by the Affymetrix Mas 5.0 software in six of the six colon cancer cell lines with significantly lower expression of EGFR were identified. Second, it was required that these probe sets would be judged to be present in at least six cell lines of the twenty five cell lines classified as having significant mRNA expression of the EGFR. This analytical strategy resulted in the identification of 280 probe sets that could be analyzed in comparison to the discovery probe set list IC-50-B.
The discovery probe set list EGFR-B was generated by selecting all probe sets which were judged to be absent by the Affymetrix Mas 5.0 software in five of the six colon cancer cell lines with significantly lower expression of EGFR and which would be present in at least six cell lines of the twenty five cell lines classified as having significant mRNA expression of the EGFR. Discovery probe set list EGR-B
contains 1,852 probe sets (LJ133A: 876; U133B: 976).

Identifying Genes that Significantly Correlate with Drug Resistance/Sensitivity Classification Expression profiling data of 44,792 probe sets represented on the HG-U133 array set far twenty two untreated colon cell lines were obtained and preprocessed as described in Example 1 below. These data were analyzed using the Student's TTEST
to identify genes whose expression patterns were strongly correlated with the drug resistance/sensitivity classification. Table 1 provides the resistance/sensitivity phenotype classification of the twenty two colon cell lines for the EGFR
antagonist BMS-461453 based on the ICSO results. The mean ICSO values along with standard deviations (SD) were calculated from 2 to 5 individual determinations for each cell line as shown. The mean ICSO across the twenty two colon cell lines for BMS-was calculated and used to normalize the ICSO data for each cell line. A11 cell lines with at least a 1.75 fold lower ICSO than the most resistant cell lines were considered to be sensitive to treatment with BMS-461453. The cell lines designated with an asterisk are defined as being sensitive to the drug treatment.

TABLE 1 - Resistance/Sensitivity Phenotype Classification of Twenty Two Colon Cell Lines Cell lines ICso SD

CCD 33C0* 2 1.28 LOVO* 2.3 2.28 LSI 74T* 3.5 1.93 Caco2* 5.5 3.97 SW403 * 5.7 4.94 CCDIBCo 7.1 3.84 SW837 7.2 3.30 Sk-Co-1 9 2.02 MIP 9.7 0.52 SW1417 10 0.00 HT-29 10 0.00 T84 10 0.00 CX-1 10 0.00 Colo-205 10 0.00 Colo-201 10 0.00 Co1o320HSR 10 0.00 HCT8 10 0.00 Co1o320DM 10 0.00 SW480 10 0.00 HCT116 10 0.00 SW620 10 0.00 HCTl 165542 10 0.00 An "idealized expression pattern" corresponds to a gene that is uniformly high in one class (e.g., sensitive) and uniformly low in the other (e.g., resistant).
Initially, a Student TTEST was performed in which a T value was obtained for each probe set.
Once a T value was generated, its corresponding confidence value (P) was found on a standard table of significance. The confidence value is a measure of the probability to observe a certain mean expression difference between two groups by chance alone and is obtained using the following formula:

T(g.C) _ (Xl - X2) / ( Varl/nl '+' Var2/n2)1l2 wherein, T(g,c) represents the T value between expression for gene g and the sensitivity/resistance classification c;
Xl represents mean gene expression level of samples in class 1;
X2 represents mean gene expression level of samples in class 2;
varl represents variance of gene expression for samples in class 1;
var,~ represents variance of gene expression for samples in class 2;
nl represents number of samples in class 1;
nz represents number of samples in class 2; and corresponding confidence value (P) for T values are obtained from a standard table of significance.
To generate discovery probe set list IC-50-B, a confidence value of 0.05 or lower was used as the cut off for probe sets to be included in the list.
Discovery probe set list IC-50-B contains 5,050 probe sets (LT133A: 2,498; U133B: 2,552).
Discovery probe set list IC-50-A was generated using the Pearson correlation coefficient (a dimensionless index that ranges from -1.0 to 1.0). This value was calculated by treating the IC50 data as continuous variables and by utilizing a lineax regression model to correlate gene expression levels with ICSO values for twenty-two colon cell lines. Probe sets with a correlation coefficient less than -0.5 were selected (p <0.02), a total of 902 probe sets (LT133A: 467; U133B: 435).
Finally, two separate biomarker probe set lists were generated, biomarker probe set lists A and B, by identifying probe sets which were present in EGFR-A and IC-50-B (Biomarker Probe Set List A) (Table 2) or were present in EGFR-B and IC-50-A (Biomarker Probe Set List B) (Table 3).
The biomarker probe set list A (Table 2) contains a total of 74 probe sets (U133A: 43; U133B: 31) and provides the polynucleotides identified to be biomarkers of EGFR antagonist sensitivity employing strategy A. With strategy A, polynucleotides were required to satisfy a stringent criteria for EGFR status coregulation and a less stringent condition for correlation to IC$o values.
Namely, the polynucleotides had to be called absent by the Affymetrix software in six out of the six cell lines with lowest expression of EGFR and be differentially expressed in the sensitive and resistance cell lines with a P value equal to or less than 0.05.
TABLE 2 - Biomarker Probe Set List A
Unigene TitleAffymetrix Description Affymetrix robe set hemoglobin, gb:BC005931.1 /DEF=Homo Sapiens, 211745 x at alpha 1 hemoglobin, alpha 2, clone MGC:14541, mRNA, complete cds. /FEA=mRNA

/PROD=hemoglobin, alpha 2 /DB XREF= 1:13543547 /FL= b:BC005931.1 dipeptidylpeptidagb:M80536.1 /DEF=H.sapiens dipeptidyl203716 s_at se IV (CD26, peptidase IV (DPP4) mRNA, complete cds.

adenosine /FEA=mRNA /GEN=DPP4 /PROD=dipeptidyl deaminase peptidase IV /DB XREF=gi:181569 complexing /IJG=Hs.44926 dipeptidylpeptidase IV (CD26, protein 2) adenosine deaminase complexing protein 2) /FL= b:M80536.1 gb:NM 001935.1 spondin 1, Consensus includes gb:AI885290 /FEA=EST213994~s (f at spondin) /DB XREF=gi:5590454 extracellular/DB XREF=est:w192a04.x1 matrix protein/CLONE=IMAGE:2432334 /UG=Hs.5378 spondin 1, (f spondin) extracellular matrix protein 3-hydroxy-3- gb:NM 005518.1 /DEF=Homo sapiens 204607 at methylglutaryl-hydroxy-3-methylglutaryl-Coenzyme A synthase Coenzyme A 2 (mitochondrial) (HMGCS2), mRNA.

synthase 2 /FEA=mRNA /GEN=HMGCS2 /PROD=3-(mitochondrial)hydroxy-3-methylglutaryl-Coenzyme A synthase 2(mitochondrial) /DB XREF=gi:5031750 /LTG=Hs.59889 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) /FL= b:NM 005518.1 mucin 2, gb:NM 002457.1 /DEF=Homo sapiens 204673 at mucin 2, intestinal/tracheaintestinaltracheal (MUC2), mRNA.1FEA=mRNA

1 /GEN=MUC2 /PROD=mucin 2, intestinaltracheal /DB XREF=gi:4505284 /LTG=Hs.315 mucin 2, intestinaltracheallFL=gb:NM 002457.1 gb:L21998.1 cystic fibrosisgb:NM_000492.2 /DEF=Homo Sapiens 205043 at cystic transmembranefibrosis transmembrane conductance regulator, conductance ATP-binding cassette (sub-family C, member 7) regulator, (CFTR), mRNA. /FEA=mRNA /GEN=CFTR
ATP-binding cassette/PROD=cystic fibrosis transmembrane (sub-family conductanceregulator, ATP-binding C, cassette (sub-member 7) family C, member 7) /DB XRFF= 1:6995995 /LTG=Hs.663 cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) /FL=gb:NM
000492.2 CUG triplet Consensus includes gb:N36839 /FEA=EST202156 s_at repeat, RNA- lDB XRFF=gi:1157981 i binding proteinXREF=est:yy35~7.s1 /CLONE=IMAGE:273253 /UG=Hs.211610 CUG

triplet repeat, RNA-binding protein !FL=gb:U69546.1 gb:AF036956.1 gb:AF090694.1 b:NM 006561.1 nuclear receptorgb:NM_000901.1 /DEF=Homo Sapiens 205259 at nuclear subfamily receptor subfamily 3, group C, member 3, 2 group C, member(NR3C2), mRNA. /FEA=mRNA /GEN NR3C2 2 /PROD=nuclear receptor subfamily 3, group C, member 2 !DB XREF=gi:4505198 /LJG=Hs.1790 nuclear receptor subfamily 3, group C, member 2 /FL=gb:M16801.1 gb:NM 000901.1 cystic fibrosisConsensus includes gb:W60595 /FEA=EST215702~s at transmembrane/DB XREF=gi:1367354 conductance /DB XREF=est:zc91b04.s1 regulator, /CLONE=IMAGE:338479 /LTG=Hs.663 ATP- cystic binding cassettefibrosis transmembrane conductance regulator, (sub-family ATP-binding cassette (sub-family C, C, member 7) member 7) cytochrome gb:NM 000775.1 /DEF=Homo Sapiens 205073 at P450, subfamilycytochrome P450, subfamily IIJ (arachidonicd aci IIJ (arachidonicepoxygenase) polypeptide 2 (CYP2J2), mRNA.

acid /FEA=mRNA IGEN=CYP2J2 epoxygenase) /PROD=cytochrome P450, subfamily IIJ

polypeptide (arachidonic acidepoxygenase) polypeptide /DB XREF=gi:4503226 /UG=Hs.152096 cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2 /FL=gb:U37143.1 b:NM 000775.1 cystatin S gb:NM 001899.1 /DEF=Homo Sapiens 206994 at cystatin S

(CST4), mRNA. /FEA=mRNA /GEN=CST 4 /PROD=cystatin S /DB XREF=gi:4503108 /LTG=Hs.56319 cystatin S /FL=gb:NM
001899.1 spondin 1, Consensus includes gb:AI885290 /FEA=EST213993 at (f spondin) lDB_XREF=gi:5590454 extracellularlDB XREF=est:w192a04.x1 matrix protein/CLONE=IMAGE:2432334 /UG=Hs.5378 spondin 1, (f spondin) extracellular matrix rotein fibroblast 022969.1 /DEF=Homo sapiens fibroblast203638 s_at growth gb:NM

factor receptor_ d 2 growth factor receptor 2 (bacteria-expresse (bacteria- kinase, keratinocyte growth factor receptor, ex ressed craniofacial dysostosis 1, Crouzon kinase, syndrome, keratinocyte Pfeiffer syndrome, Jackson-Weiss syndrome) growth factor(FGFR2), transcript variant 2, mRNA.

receptor, /FEA=mRNA /GEN=FGFR2 /PROD=fibroblast craniofacial growth factor receptor 2, isoform 2precursor dysostosis lDB_XREF=gi:131862521LJG=Hs.278581 l, Crouton fibroblast growth factor receptor 2 (bacteria-syndrome, expressed kinase, keratinocyte growth factor Pfeiffer receptor, craniofacial dysostosis 1, Crouton syndrome, syndrome, Pfeiffer syndrome, Jackson-Weiss Jackson-Weisssyndrome) /FL=gb:NM 022969.1 gb:M97193.1 syndrome) gb:M80634.1 mucin 3B Consensus includes gb:AB038783.1 214898 x lDEF=Homo at sapiens MUC3B mRNA for intestinal mucin, partial cds. /FEA=mRNA /GEN=MUC3B

JPROD=intestinal mucin !DB XREF=gi:9929917 /LJG=Hs.129782 mucin 3A, intestinal AA Consensus includes gb:AV728958 /FEA=EST212703 at /DB_~REF=gi:10838379 /DB XREF=est:AV728958 /CLONE=HTCBYF04 /LJG=Hs.150443 KIAA0320 rotein CUG triplet gb:NM 006561.1 /DEF=Homo Sapiens 202158 s_at CUG

repeat, RNA- triplet repeat, RNA-binding protein 2 (CUGBP2), binding proteinmRNA. /FEA=mRNA /GEN=CUGBP2 /PROD=CUG triplet repeat, RNA-binding protein 2 /DB XREF=gi:5729815 /UG=Hs.211610 CUG

triplet repeat, RNA-binding protein /FL=gb:U69546.1 gb:AF036956.1 gb:AF090694.1 gb:NM 006561.1 spondin 1, gb:AB051390.1 /DEF=Homo Sapiens 209437_s_at (f mRNA for spondin) VSGPF-spondin, complete cds. IFEA=mRNA

extracellular/PROD=VSGPF-spondin matrix protein/DB XREF=gi:l 1320819 /LJG=Hs.5378 spondin 1, (f spondin) extracellular matrix protein /FL= b:AB051390.1 mucin 3B Consensus includes gb:AF113616 /DEF=Homo214676 x at sapiens intestinal mucin 3 (MUC3) gene, partial cds /FEA=mRNA /DB_XREF=gi:6466800 /UG=Hs.129782 mucin 3A, intestinal EphAl gb:NM 005232.1 /DEF=Homo Sapiens 205977 s_at EphAl (EPHA1), mRNA. /FEA=mRNA /GEN=EPHAl /PROD=EphAl /DB_~REF=gi:4885208 /LJG=Hs.89839 EphAl /FL=gb:M18391.1 b:NM 005232.1 matrilin 3 gb:NM_002381.2 /DEF=Homo Sapiens 206091 at matrilin 3 (MATN3) precursor, mRNA. /FEA=mRNA

/GEN=MATN3 /PROD=matrilin 3 precursor /DB ~~REF= 1:13518040 /LTG=Hs.278461 matrilin 3 /FL=gb:NM 002381.2 bone 001200.1 /DEF=Homo sapiens bone 205290 s_at gb:NM

morphogenetic_ morphogenetic protein 2 (BMP2), mRNA.

protein 2 /FEA=mRNA /GEN=BMP2 /PROD=bone morphogenetic protein 2 precursor /DB XREF=gi:4557368 /UG=Hs.73853 bone mo hogenetic rotein 2 /FL=gb:NM
001200.1 interferon Consensus includes gb:A1073984 /FEA=EST204057 at consensus /DB_~~REF=gi:3400628 sequence binding/DB XREF=est:oy66cO5.x1 protein 1 /CLONE=IMAGE:1670792 lUG=Hs.14453 interferon consensus sequence binding protein 1 /FL= b:M91196.1 gb:NM 002163.1 retinoic acidConsensus includes gb:AI669229 /FEA=EST221872~at receptor /DB XREF=gi:4834003 responder /DB XREF=est:wc13e06.x1 (tazarotene /CLONE=IMAGE:2315074 /LTG=Hs.82547 induced) 1 retinoic acid receptor responder (tazarotene induced) 1 cystic fibrosisConsensus includes gb:W60595 /FEA=EST215703 at transmembranelDB_XREF=gi:1367354 conductance /DB XREF=est:zc91b04.s1 regulator, /CLONE=IMAGE:338479 /LTG=Hs.663 ATP- cystic binding cassettefibrosis transmembrane conductance regulator, (sub-family ATP-binding cassette (sub-family C, C, member 7) member 7) fibroblast gb:M87771.1 IDEF=Human secreted 208228 s growth fibroblast at factor receptorgrowth factor receptor (K-sam-III) 2 mRNA, (bacteria- complete cds. /FEA=mRNA /GEN=K-sam-III

expressed /PROD=fibroblast growth factor receptor kinase, keratinocyte fDB_XREF=gi:1867811UG=Hs.278581 growth factorfibroblast growth factor receptor 2 (bacteria-receptor, expressed kinase, keratinocyte growth factor craw ofacial receptor, craniofacial dysostosis 1, Crouzon dysostosis syndrome, Pfeiffer syndrome, Jackson-Weiss 1, Crouzon syndrome) /FL=gb:NM 022970.1 gb:M87771.1 syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) myosin, heavygb:NM_003802.1 /DEF=Homo sapiens 208208 at myosin, polypeptide heavy polypeptide 13, skeletal muscle 13, (MYH13), skeletal musclemRNA. /FEA=mRNA /GEN=MYH13 /PROD=myosin, heavy polypeptide 13, skeletal muscle /DB XREF=gi:11321578 /LTG=Hs.278488 myosin, heavy polypeptide 13, skeletal muscle /FL= b:NM 003802.1 gb:AF 111782.2 ESTs, Weakly Consensus includes gb:AW675655 /FEA=EST222354 at similar to /DB XREF=gi:7540890 hypothetical /DB XREF=est:ba52e01.x1 protein /CLONE=IMAGE:2900184 /UG=Hs.314158 [H.sa iens ESTs hypothetical gb:NM 017699.1 /DEF=Homo sapiens 219734 at protein hypothetical protein FLJ20174 (FLJ20174), FLJ20174 mRNA. /FEA=mRNA /GEN=FLJ20174 /PROD=hypothetical protein FLJ20174 /DB XREF=gi:8923170 /UG=Hs.114556 hypothetical protein FLJ20174 /FL=gb:NM 017699.1 PTPRF Consensus includes gb:AI692180 /FEA=EST212841 s_at interacting /DB XREF=gi:4969520 protein, binding/DB XREF=est:Wd37fl76.x1 protein 2 /CLONE=IMAGE:2330339 /UG=Hs.12953 (liprin beta 2) PTPRF interacting protein, binding protein 2 (li rin beta 2) ribonuclease,gb:NM 002933.1 IDEF=Homo sapiens 201785 at RNase A family,ribonuclease, RNase A family, 1 ) (pancreatic 1 (pancreatic)(RNASE1), mRNA. /FEA=mRNA

/GEN=RNASE1 /PROD=ribonuclease, RNase A

family, 1 (pancreatic) /DB XREF=gi:4506546 /LTG=Hs.78224 ribonuclease, RNase A family, 1 (pancreatic) /FL=gb:BC005324.1 gb:NM 002933.1 gb:D26129.1 hairless (mouse)O18411.1 lDEF=Homo Sapiens hairless220163 s gb:NM at homolog _ protein (putative single zinc finger transcription factor protein, responsible for autosomal recessive universal congenital alopecia, HR gene) (HSA277165), mRNA. /FEA=mRNA

/GEN=HSA277165 /PROD=hairless protein /DB XREF=gi:11036651 /UG=Hs.272367 hairless protein (putative single zinc finger transcription factor protein, responsible for autosomal recessive universal congenital alopecia, HR ene) /FL=gb:NM 018411.1 nuclear receptorConsensus includes gb:AF228413.1 210174 at /DEF=Homo subfamily sapiens hepatocyte transcription 5, factor mRNA, group A, 3UTR. /FEA=mRNA /DB XREF=gi:7677372 member 2 /UG=Hs.l 83123 nuclear receptor subfamily 5, group A, member 2 /FL=gb:U93553.1 b:AB019246.1 gb:AF124247.1 superoxide gb:NM 003102.1 /DEF=Homo Sapiens 205236 x at dismutase superoxide dismutase 3, extracellular 3, (SOD3), extracellularmRNA. /FEA=mRNA /GEN=SOD3 /PROD=su eroxide dismutase 3, extracellular /DB XR.EF=gi:4507150 /UG=Hs.2420 superoxide dismutase 3, extracellular /FL= b:J02947.1 b:NM 003102.1 zinc finger gb:NM 003438.1 /DEF=Homo sapiens 207394~at zinc protein 137 finger protein 137 (clone pHZ-30) (ZNF137), (clone pHZ-3 mRNA. /FEA=mRNA /GEN=ZNF 13 7 0) /PROD=zinc finger protein 137 (clone pHZ-30) /DB XREF=gi:4507988 /LTG=Hs.151689 zinc finger protein 137 (clone pHZ-30) /FL=gb:NM 003438.1 gb:U09414.1 Homo Sapiens Consensus includes gb:AL049983.1 217288_at /DEF=Homo mRNA; cDNA sapiens mRNA; cDNA DKFZp564D042 (from DKFZp564D042 clone DKFZp564D042). /FEA=mRNA

(from clone /DB XREF=gi:4884234 /UG=Hs.240136 Homo DKFZp564D042 sapiens mRNA; cDNA DI~FZp564D042 (from clone DI~FZ 564D042) Hermansky- Consensus includes gb:AL022313 /DEF=Human217354 s at _ Pudlak syndromeDNA sequence from clone RPS-1119A7 on chromosome 22q12.2-12.3 Contains the TXN2 gene for mitochondria) thioredoxin, a novel gene, the EIF3S7 gene for eukaryotic translation initiation factor 3 subunit 7 (zeta, 6667kD) (EIF3-P66), the gene f... /FEA=CDS 3 /DB XREF=gi:4200326 /UG=Hs.272270 Human DNA sequence from clone RPS-1119A7 on chromosome 22q12.2-12.3 Contains the TXN2 gene for mitochondria) thioredoxin, a novel gene, the EIF3S7 gene for eukaryotic translation initiation factor 3 subunit 7 (zeta, 6667kD) (EIF3-P66), the ene for a nov peroxisomal 018441.1 /DEF=Homo sapiens 221142 s_at gb:NM

traps 2-enoyl_ peroxisomal traps 2-enoyl CoA reductase;

CoA reductase;putative short chain alcohol dehydrogenase putative short(HSA250303), mRNA. /FEA=mRNA

chain alcohol/GEN=HSA250303 /PROD~eroxisomal traps 2-dehydrogenaseenoyl CoA reductase;putative short chain alcohol dehydrogenase /DB XREF=gi:8923751 /UG=Hs.281680 peroxisomal traps 2-enoyl CoA

reductase; putative short chain alcohol dehydrogenase lFL=gb:NM 018441.1 BTG family gb:NM 006763.1 /DEF=Homo sapiens 201236 s BTG at , family, member 2 (BTG2), mRNA. /FEA=mRNA
member 2 /GEN=BTG2 (PROD=BTG family, member /DB XREF=gi:5802987 /UG=Hs.75462 BTG

family, member 2 /FL=gb:U72649.1 gb:NM 006763.1 phosducin gb:M33478.1 /DEF=Human 33-kDa 211496 s_at hototransducing rotein mRNA, com lete cds.

_29_ /FEA=mRNA /DB_XREF=gi:177186 /UG=Hs.550 phosducin /FL=gb:NM 022577.1 gb:M33478.1 gb:AF076465.1 Rho GTPase gb:NM_015366.1 /DEF=Homo Sapiens 205980 s Rho at activating GTPase activating protein 8 (ARHGAPB), protein g mRNA. /FEA=mRNA 1GEN=ARHGAP8 /PROD=Rho GTPase activating protein /DB XREF=gi:7656903 /UG=Hs.102336 Rho GTPase activating protein 8 /FL= b:NM 015366.1 Homo sapiens Consensus includes gb:AW593996 /FEA=EST213256~at clone 24707 /DB XREF=gi:7281254 mRNA sequence/DB XREF=est:hg41g06.x1 /CLONE=IMAGE:2948218 /UG=Hs.124969 Homo sa iens clone 24707 mRNA se uence caspase 10, gb:NM 001230.1 /DEF=Homo sapiens 205467 at caspase apoptosis-related10, apoptosis-related cysteine protease cysteine protease(CASP 10), mRNA. /FEA=mRNA

/GEN=CASP10 /PROD=caspase 10, apoptosis-related cysteine protease /DB XREF=gi:4502568 /LTG=Hs.5353 caspase 10, apoptosis-related cysteine protease 1FL=gb:U60519.1 gb:NM 001230.1 KIA.A0690 Consensus includes gb:AK000238.1 216360 x /DEF=Homo at protein Sapiens cDNA FLI20231 fis, clone COLF5511, highly similar to AB014590 Homo sapiens mRNA for I~IAA0690 protein. /FEA=mRNA

/DB XREF=gi:7020188 !UG=Hs.60103 KIAA0690 protein Homo sapiens ; Consensus includes gb:AW001287 227676 at /FEA=EST

Similar to /DB XREF=gi:5848203 RII~EN cDNA /DB XREF=est:wu27e06.x1 1810037020 /CLONE=IMAGE:2521282 /LTG=Hs.61265 gene, clone ESTs, Weakly similar to G786_HUMAN

MGC:21481 PROTEIN GS3786 H.sapiens IMAGE:385206 2, mRNA, com lete cds ESTs Consensus includes gb:AA581439 /FEA=EST244650 at -/DB XREF=gi:2359211 /DB XREF=est:nh13c10.s1 /CLONE=IMAGE:952242 /UG=Hs.152328 ESTs ESTs Consensus includes gb:AI739241 /FEA=EST238984 at -/DB XREF=gi:5101222 /DB XREF=est:wi14h02.x1 (CLONE=IMAGE:2390259 /LTG=Hs.171480 ESTs hypothetical Consensus includes gb:AB046810.1 232083~at /I7EF=Homo protein Sapiens mRNA for I~IAA1590 protein, partial FLJ23045 cds. /FEA=mRNA /GEN=I~IA.A1590 /PROD=KIAA1590 protein /DB XREF=gi:100472541UG=Hs.101774 h othetical rotein FLJ23045 regenerating gb:AY007243.1 /DEF=Homo sapiens 223447 at gene type regenerating gene type IV mRNA, IV complete cds.

/FEA=mRNA (PROD=regenerating gene type IV

/DB XREF=gi:12621025 /LTG=Hs.105484 Homo sapiens regenerating gene type IV
mRNA, com fete cds lFL=gb:AY007243.1 ESTs Consensus includes gb:AI139990 /FEA=EST231022 at /DB XREF=gi:3647447 /DB XREF=est:qa47d03.x1 /CLONE=IMAGE:1689893 /LTG=Hs.134586 ESTs ESTs Consensus includes gb:AI733801 /FEA=EST237923 at /DB XREF=gi:5054914 /DB XREF=est:qk39c04.x5 (CLONE=IMAGE:1871334 IIJG=Hs.146186 ESTs hypothetical Consensus includes gb:AI~002203.1 226992 at /DEF=Homo protein sapiens cDNA FLJ11341 fis, clone MGC20702 PLACE1010786. /FEA=mRNA

/DB XREF=gi:7023932 /LJG=Hs.10260 Homo Sapiens cDNA FLJ11341 fis, clone PLACEl010786 ESTs, Weakly Consensus includes gb:AI457984 /FEA=EST243729 at similar to /DB XREF=gi:4312002 ALU1_HUMAN /DB XREF=estaj66a04.x1 ALU /CLONE=IMAGE:2146446 /UG=Hs.165900 SUBFAMILY ESTs, Weakly similar to ALUC_HUMAN
J ! ! ! !

SEQUENCE ALU CLASS C WARNING ENTRY ! ! !

CONTAMINAT H.sapiens ION WARNING

ENTRY

[H.sa iens]

Homo Sapiens Consensus includes gb:T86159 /FEA=EST227724 at cDNA: lDB_xR.EF=gi:714511 FLJ22063 fis,/DB XREF=est:yd84h07.s1 clone HEP10326/CLONE=IMAGE:114973 /UG=Hs.10450 Homo sapiens cDNA: FLJ22063 fis, clone ESTs Consensus includes gb:AI806131 /FEA=EST231148 at /DB XREF=gi:5392697 /DB XREF=est:wf06c06.x1 /CLONE=IMAGE:2349802 /UG=Hs.99376 ESTs _ anterior gradientConsensus includes gb:AI922323 /FEA=EST228969 at 2 (Xenepus lDB_~~REF=gi:5658287 laevis) homolog/DB XREF=est:wn90h03.x1 /CLONE=IMAGE:2453141 /UG=Hs.293380 ESTs ESTs Consensus includes gb:AI493909 /FEA=EST235562 at /DB XRFF=gi:4394912 !DB_~~REF=est:qz94e02.x1 /CLONE=IMAGE:2042234 /UG=Hs.6131 ESTs hypothetical Consensus includes gb:AI339568 /FEA=EST222727 s at protein /DB_~~REF=gi:4076495 FLJ22233 /DB XREF=est:qk67e10.x1 /CLONE=IMAGE:1874058 /UG=Hs.286194 hypothetical protein FLJ22233 /FL=gb:NM 024959.1 GaINAc alpha-2,Consensus includes gb:Y11339.2 /DEF=Homo227725 at 6- sapiens mRNA for GaINAc alpha-2, sialyltransferasesialyltransferase I, long form.
/FEA=mRNA

I, long form /PROD=GaINAc alpha-2,6-sialyltransferase I

/DB XREF=gi:75762751UG=Hs.105352 GaINAc al ha-2, 6-sialyltransferase I, long form ESTs Consensus includes gb:AI917390 /FEA=EST240964 at /DB XREF=gi:5637245 IDB_XREF=estas79a05 .x 1 /CLONE=IMAGE:2237456 /UG=Hs.99415 ESTs Homo Sapiens Consensus includes gb:AI~026404.1 232321 at /DEF=Homo cDNA: sapiens cDNA: FLJ22751 fis, clone KAIA0483, FLJ22751 fis,highly similar to AF016692 Homo Sapiens small clone intestinal mucin (MLTC3) mRNA. /FEA=mRNA

KAIA0483, /DB_~~REF=gi:10439257 /UG=Hs.271819 Homo highly similarsapiens cDNA: FLJ22751 fis, clone to I~AIA0483, AF016692 Homohighly similar to AF016692 Homo sapiens small sapiens smallintestinal mucin (MUC3) mRNA

intestinal mucin (MLTC3) mRNA

Homo Sapiens Consensus includes gb:AK026984.1 229021 at /DEF=Homo cDNA: Sapiens cDNA: FLJ23331 fis, clone HEP12664.

FLJ23331 fis,/FEA=mRNA /DB_XREF=gi:10439980 clone HEP12664/UG=Hs.50742 Homo Sapiens cDNA:

fis, clone HEP 12664 ESTs Consensus includes gb:AA827649 /FEA=EST235515 at /DB XR.EF=gi:2900090 /DB XREF=est:od01a12.s1 /CLONE=IMAGE:1357918 /UG=Hs.105317 ESTs rostate cancerConsensus includes b:AA633076 /FEA=EST226167 at associated /DB XREF=gi:2556490 protein 7 /DB_~REF=est:nq38a06.s1 /CLONE=IMAGE:l 146130 /UG=Hs.27495 rostate cancer associated rotein ESTs Consensus includes gb:N37023 /FEA=EST225407 at /DB XREF=gi:1158165 /DB XREF=est:yy40d03.s1 (CLONE=IMAGE:273701 /UG=Hs.235883 ESTs ESTs, Weakly Consensus includes gb:AI864053 /FEA=EST235678 at similar to lDB XREF=gi:5528160 reverse /DB_XREF=est:wj S Shl0.x1 transcriptase/CLONE=IMAGE:2406787 /UG=Hs.39972 homolog ESTs, Weakly similar to I38588 reverse [H.sa iens transcri tase homolog H.sa iens ESTs, Weakly Consensus includes gb:AA557324 /FEA=EST227702 at similar to /DB XREF=gi:2327801 JX03311aurate!DB XREF=est:n181a02.s1 omega- /CLONE=IMAGE:1057034 /UG=Hs.26040 hydroxylase ESTs, Weakly similar to fatty acid omega-[H.sa fens] hydroxylase H.sa iens ESTs Consensus includes gb:BF594323 /FEA=EST238103 at /DB X_RFF=gi:11686647 JDB XREF=est:7h79g07.x1 /CLONE=IMAGE:3322236 /LJG=Hs.158989 ESTs ESTs, Weakly Consensus includes gb:AI827789 /FEA=EST228241 at similar to /DB XREF=gi:5448449 JE0350 Anterior/DB XREF=est:wf33a07.x1 gradient-2 /CLONE=IMAGE:2357364 /UG=Hs.100686 [H.sapiens] ESTs, Weakly similar to JE0350 Anterior adient-2 H.sa iens ESTs Consensus includes gb:AI968097 /FEA=EST237835 at /DB XREF=gi:5764915 /DB XREF=est:wu13a12.x1 /CLONE=IMAGE:2516830 /UG=Hs.131360 ESTs ESTs Consensus includes gb:H05025 /FEA=EST241874 at /DB XREF=gi:868577 /DB XREF=est:yl74g12.s1 /CLONE=IMAGE:43864 /UG=Hs.323767 ESTs Homo sapiens,Consensus includes gb:AA524690 /FEA=EST226168 at Similar to /DB XREF=gi:2265618 RII~EN cDNA /DB_~~REF=est:ng38e07.s1 1110060018 /CLONE=IMAGE:937092 /UG=Hs.294143 gene, clone ESTs, Weakly similar to predicted using MGC:17236 Genefinder C.elegans IMAGE:3 86413 7, mRNA, com fete cds ESTs Consensus includes gb:AI300126 /FEA=EST240830 at /DB XREF=gi:3959472 /DB XREF=est:qn54IU2.x1 /CLONE=IMAGE:1902075 /UG=Hs.257858 ESTs Homo sapiens Consensus includes gb:AA129774 /FEA=EST227019~at cDNA FLJ13137/DB XREF=gi:1690185 fis, clone /DB XREF=est:z116h09.s1 NT2RP3003150 /CLONE=IMAGE:502145 /UG=Hs.288905 Homo sapiens cDNA FLJ13137 fis, clone ESTs Consensus includes gb:AW024656 /FEA=EST242358 at !DB XREF=gi:5878186 /DB XREF=est:wu78hO5.x1 /CLONE=IMAGE:2526201 /UG=Hs.233382 ESTs, Moderately similar to AF119917 PR02822 H.sapiens The biomarker probe set list B (Table 3) contains 95 probe sets (U133A: 47;
U133B 48). The biomarker probe set list B contains polynucleotides identified to be biomarkers of EGFR antagonist sensitivity employing strategy B. In strategy B, polynucleotides were required to satisfy a stringent criteria for correlation to IC$o values and a less stringent condition for EGFR status coregulation. Namely, the polynucleotides had to have a Pearsons correlation of -0.5 or less with respect to ICS
and be called absent by the Affymetrix software in 5 out of the 6 cell lines with lowest expression of EGFR.
TABLE 3 - Biomarker Probe Set List B
Unigene TitleAffymetrix Description Affymetrix robe set dopa Consensus includes gb:AW772056 /FEA=EST214347 s-at decarboxylase/DB XREF=gi:7704118 (aromatic /DB XREF=est:hn64g06.x1 L-amino acid /CLONE=IMAGE:3032698 JUG=Hs.150403 decarboxylase)dopa decarboxylase (aromatic L-amino acid decarboxylase) cystic fibrosisgb:NM 000492.2 IDEF=Homo Sapiens 205043 at cystic transmembranefibrosis transmembrane conductance regulator, conductance ATP-binding cassette (sub-family C, member 7) regulator, (CFTR), mRNA. /FEA=mRNA /GEN=CFTR
ATP-binding cassette/PROD=cystic fibrosis transmembrane (sub-family conductanceregulator, ATP-binding C, cassette member 7) (sub-family C, member 7) ~

/DB XREF=gi:6995995 /UG=Hs.663 cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) /FL=gb:NM 000492.2 carcinoembryoiugb:BC005008.1 /DEF=Homo sapiens, 203757 s at c antigen-relatedcarcinoembryonic antigen-related cell adhesion cell adhesionmolecule 6 (non-specific cross reacting antigen), molecule 6 clone MGC:10467, mRNA, complete (non- cds.

specific cross/FEA=mRNA /PROD=carcinoembryonic reacting antigen)antigen-related cell adhesionmolecule 6 (non-specific cross reacting antigen) /DB XRFF=gi:13477106 /UG=Hs.73848 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) /FL=gb:BC005008.1 gb:M18216.1 gb:M29541.1 gb:NM 002483.1 hypothetical gb:NM 017655.1 /DEF=Homo sapiens 219970 at protein hypothetical protein FLJ20075 (FLJ20075), FLJ20075 mRNA. /FEA=mRNA /GEN=FLJ20075 /PROD=hypothetical protein FLJ20075 /DB XREF=gi:8923083 /UG=Hs.205058 hypothetical protein FLJ20075 /FL= b:NM 017655.1 ATPase, ClassConsensus includes gb:AW006935 214070 s IFEA=EST at V, type 10B /DB XREF=gi:5855713 /DB XREF=est:wt08b11.x1 /CLONE=IMAGE:2506845 /UG=Hs.109358 ATPase, Class V, type lOB

cystic fibrosisConsensus includes gb:W60595 IFEA=EST215702 s_at transmembrane/DB XREF=gi:1367354 conductance /DB XREF=est:zc91b04.s1 regulator, /CLONE=IMAGE:338479 /UG=Hs.663 ATP- cystic binding cassettefibrosis transmembrane conductance regulator, (sub-family ATP-binding cassette (sub-family C, C, member 7) member 7) HERV-H LTR- gb:NM 007072.1 /DEF=Homo Sapiens 220812 s_at HERV-associating H LTR-associating 2 (HHLA2), mRNA.

/FEA=mRNA IGEN=HHLA2 /PROD=HERV-H

LTR-associating 2 /DB XREF=gi:5901963 /UG=Hs.252351 HERV-H LTR-associating /FL=gb:AF126162.1 gb:NM 007072.1 AA Consensus includes gb:AV728958 212703 at /FEA=EST

/DB XREF=gi:10838379 /DB XREF=est:AV728958 /CLONE=HTCBYF04 /UG=Hs.150443 KIAA0320 protein hemoglobin, Consensus includes gb:T50399 /FEA=EST214414 x at alpha 2 /DB XREF=gi:652259 /DB XREF=est: yb3 Ob 11. s 1 /CLONE=IMAGE:72669 /UG=Hs.251577 hemo lobin, al ha 1 spondin 1, Consensus includes gb:AI885290 213993 at (f /FEA=EST

spondin) /DB XREF=gi:5590454 extracellular/DB XREF=est:w192a04.x1 matrix protein/CLONE=IMAGE:2432334 /UG=Hs.5378 spondin 1, (f spondin) extracellular matrix rotein hemoglobin, gb:BC005931.1 /DEF=Homo sapiens, 211745 x at alpha 1 hemoglobin, alpha 2, clone MGC:14541, mRNA, complete cds. /FEA=mRNA

/PROD=hemoglobin, alpha 2 /DB XREF= 1:13543547 /FL= b:BC005931.1 serine (or gb:NM_002639.1 /DEF=Homo Sapiens 204855 at serine cysteine) (or cysteine) proteinase inhibitor, Glade B

proteinase (ovalbumin), member 5 (SERPINBS), mRNA.

inhibitor, /FEA=mRNA /GEN=SERPINBS /PROD=serine Glade B

(ovalbumin), (or cysteine) proteinase inhibitor, cladeB

member 5 (ovalbumin), member 5 /DB XREF=gi:4505788 /LTG=Hs.55279 serine (or cysteine) proteinase inhibitor, Glade B (ovalbumin), member 5 /FL=gb:NM 002639.1 gb:U04313.1 3-hydroxy-3- gb:NM 005518.1 /DEF=Homo sapiens 204607 at methylglutaryl-hydroxy-3-methylglutaryl-Coenzyme A synthase Coenzyme A 2 (mitochondrial) (HMGCS2), mRNA.

synthase 2 /FEA=mRNA /GEN=HMGCS2 /PROD=3-(mitochondrial)hydroxy-3-methylglutaryl-Coenzyme A synthase 2(mitochondrial) /DB XREF=gi:5031750 /LJG=Hs.59889 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) /FL=gb:NM_005518.1 anterior gradientgb:AF088867.1 /DEF=Homo Sapiens 209173 at putative 2 (Xenepus secreted protein XAG mRNA, complete Gds.

laevis) homolog/FEA=mRNA /PROD~utative secreted protein XAG /DB XREF=gi:6652811 /LTG=Hs.91011 anterior gradient 2 (Xenepus laevis) homolog /FL=gb:AF007791.1 gb:AF038451.1 b:NM 006408.1 b:AF088867.1 FXYD domain- gb:BC005238.1 /DEF=Homo Sapiens, 202489 s FXYD at containing domain-containing ion transport ion regulator 3, transport clone MGC:12265, mRNA, complete Gds.

regulator /FEA=mRNA /PROD=FXYD domain-containing ion transport regulator3 /DB XREF=gi:13528881 /LTG=Hs.301350 FXYD domain-containin ion trans ort regulator 3 /FL= b:NM 005971.2 gb:BC005238.1 dipeptidylpeptidagb:M80536.1 /DEF=H.sapiens dipeptidyl203716 s_at se IV (CD26, peptidase IV (DPP4) mRNA, complete cds.

adenosine /FEA=mRNA /GEN=DPP4 /PROD=dipeptidyl deaminase peptidase IV lDB_~iREF=gi:181569 complexiiig /LTG=Hs.44926 dipeptidylpeptidase IV (CD26, protein 2) adenosine deaminase complexing protein 2) lFL=gb:M80536.1 gb:NM_001935.1 cystic fibrosisConsensus includes gb:W60595 /FEA=EST215703 at transmembrane/DB XREF=gi:1367354 conductance /DB XREF=est:zc91b04.s1 regulator, /CLONE=IMAGE:338479 IUG=Hs.663 ATP- cystic binding cassettefibrosis transmembrane conductance regulator, (sub-family ATP-binding cassette (sub-family C, C, member 7) member 7) EphAl gb:NM 005232.1 /DEF=Homo Sapiens 205977 s_at EphAl (EPHA 1 ), mRNA. /FEA=mRNA /GEN=EPHA1 /PROD=EphAl !DB XREF=gi:4885208 /LTG=Hs.89839 EphAl /FL=gb:M18391.1 b:NM 005232.1 spondin l, Consensus includes gb:AI885290 213994_s_at (f /FEA=EST

spondin) /DB XREF=gi:5590454 extracellular/DB XREF=est:w192a04.x1 matrix protein/CLONE=IMAGE:2432334 /UG=Hs.5378 spondin 1, (f spondin) extracellular matrix protein CUG triplet gb:NM 006561.1 /DEF=Homo sapiens 202158 s_at CUG

repeat, RNA- triplet repeat, RNA-binding protein binding protein(CUGBP2), mRNA. /FEA--mRNA

/GEN=CUGBP2 /PROD=CUG triplet repeat, RNA-binding protein 2 /DB XREF=gi:5729815 /LJG=Hs.211610 CUG triplet repeat, RNA-binding protein 2 /FL=gb:U69546.1 gb:AF036956.1 gb:AF090694.1 gb:NM 006561.1 DKFZP434C091 Consensus includes gb:AL080170.1 215047 at protein /DEF=Homo Sapiens mRNA; cDNA

DKFZp434C091 (from clone DKFZp434C091);

partial cds. /FEA=mRNA

IGEN=DKFZp434C091 (PROD=hypothetical protein /DB XREF=gi:5262639 /UG=Hs.51692 DKFZP434C091 protein mucin 3B Consensus includes gb:AF113616 214676_x_at /DEF=Homo Sapiens intestinal mucin 3 (MUC3) gene, partial cds /FEA=mRNA /DB XREF=gi:6466800 /UG=Hs.129782 mucin 3A, intestinal potassium gb:U90065.1 /DEF=Human potassium 204678 s_at channel channel, KCNO1 mRNA, com fete cds. /FEA=mRNA

subfamily /PROD=potassium channel KCNO1 K, member 1 IDB XREF=gi:1916294 /UG=Hs.79351 (TWIK-1) potassium channel, subfamily K, member 1 (TWIK-1) /FL=gb:U33632.1 gb:U90065.1 gb:U76996.1 gb:NM 002245.1 nuclear receptorgb:NM 000901.1 /DEF=Homo Sapiens 205259 at nuclear subfamily receptor subfamily 3, group C, 3, member 2 group C, member(NR3 C2), mRNA. /FEA=mRNA /GEN--NR3 2 /PROD=nucleax receptor subfamily 3, group C, member 2 /DB XREF=gi:4505198 /UG=Hs.1790 nuclear receptor subfamily 3, group C, member 2 /FL=gb:M16801.1 gb:NM 000901.1 BTG family, gb:NM 006763.1 /DEF=Homo Sapiens 201236 s BTG at member 2 family, member 2 (BTG2), mRNA.

/FEA=mRNA IGEN=BTG2 /PROD=BTG

family, member 2 /DB XREF=gi:5802987 /IJG=Hs.75462 BTG family, member /FL=gb:U72649.1 b:NM 006763.1 G protein- gb:AF062006.1 /DEF=Homo Sapiens 210393 at orphan G

coupled receptorprotein-coupled receptor HG38 mRNA, 49 complete cds. /FEA=mRNA /PROD=orphan G

protein-coupled receptor HG3 8 /DB XREF=gi:3366801 /UG=Hs.285529 G

protein-coupled receptor 49 /FL=gb:AF062006.1 b:AF061444.1 gb:NM 003667.1 hypothetical gb:NM 017640.1 IDEF=Homo Sapiens 219573lat protein hypothetical protein FLJ20048 (FLJ20048), FLJ20048 mRNA. /FEA=mRNA /GEN=FLJ20048 /PROD=hypothetical protein FLJ20048 !DB_~REF=gi:8923056 /L1G=Hs.116470 hypothetical protein FLJ20048 /FL=gb:NM 017640.1 cytochrome gb:NM 000775.1 /DEF=Homo Sapiens 205073 at P450, subfamilycytochrome P450, subfamily IIJ
(arachidonic IIJ (arachidonicacid epoxygenase) polypeptide 2 (CYP2J2), acid mRNA. /FEA=mRNA /GEN=CYP2J2 epoxygenase) /PROD=cytochrome P450, subfamily IIJ

polypeptide (arachidonic acidepoxygenase) polypeptide /DB XREF=gi:4503226 /UG=Hs.152096 cytochrome P450, subfamily IIJ
(arachidonic acid epoxygenase) polypeptide 2 lFL= b:U37143.1 gb:NM 000775.1 brain-specificgb:NM 007030.1 /DEF=Homo sapiens 206179 s_at brain-protein p25 specific protein p25 alpha (p25), alpha mRNA.

IFEA=mRNA JGEN=p25 /PROD=brain-specific protein p25 alpha /DB XREF=gi:5902017 ICTG=Hs.29353 brain-s ecific rotein 25 al ha /FL=gb:AB017016.1 gb:NM 007030.1 mucin 2, gb:NM 002457.1 /DEF=Homo Sapiens 204673 at mucin 2, intestinal/tracheaintestinaltracheal (MUC2), mRNA.

1 /FEA=mRNA /GEN=MUC2 /PROD=mucin 2, intestinaltracheal /DB XREF=gi:4505284 /LTG=Hs.315 mucin 2, intestinaltracheal /FL=gb:NM 002457.1 gb:L21998.1 hypothetical gb:NM 017699.1 /DEF=Homo Sapiens 219734 at protein hypothetical protein FLJ20174 (FLJ20174), FLJ20174 mRNA. /FEA~nRNA /GEN=FLJ20174 (PROD=hypothetical protein FLJ20174 /DB XREF=gi:8923170 /LTG=Hs.114556 hypothetical protein FLJ20174 /FL=gb:NM 017699.1 metastasis- gb:NM 004739.1 lDEF=Homo sapiens 203444 s at associated metastasis-associated 1-like 1 1-like (MTA1L1), 1 mRNA. /FEA--mRNA /GEN=MTA 1 L 1 /PROD=metastasis-associated 1-like /DB XR.EF=gi:4758739 /LJG=Hs.173043 metastasis-associated 1-like 1 /FL=gb:AB016591.1 gb:NM 004739.1 b:AF295807.1 bone gb:NM_001200.1 /DEF=Homo Sapiens 205290 s_at bone morphogeneticmorphogenetic protein 2 (BMP2), mRNA.

protein 2 /FEA=mRNA /GEN=BMP2 /PROD=bone morphogenetic protein 2 precursor /DB XREF=gi:4557368 IIJG=Hs.73853 bane morpho enetic protein 2 /FL=gb:NM
001200.1 heparanase gb:NM 006665.1 /DEF=Homo Sapiens 219403 s_at heparanase (HPSE), mRNA. /FEA=mRNA

/GEN=HPSE /PROD=heparanase /DB XREF=gi:5729872 /LTG=Hs.44227 heparanase /FL=gb:AF165154.1 gb:AF152376.1 gb:NM 006665.1 gb:AF084467.1 gb:AF155510.1 tumor necrosisgb:BC002794.1 IDEF=Homo Sapiens, 209354 at tumor factor receptornecrosis factor receptor superfamily,4 member 1 superfamily, (herpesvirus entry mediator), clone MGC:3753, member 14 mRNA, complete cds. /FEA=mRNA

(herpesvirus /PROD=tumor necrosis factor receptor entry mediator)superfamily,member 14 (herpesvirus entry mediator) /DB XREF=gi:12803894 iUG=Hs.279899 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) /FL=gb:BC002794.1 gb:U70321.1 gb:U81232.1 gb:NM 003820.1 b:AF153978.1 CUG triplet Consensus includes gb:N36839 /FEA=EST202156 s_at re eat, RNA- /DB ~~REF= 1:1157981 binding protein/DB XREF=est:yy35f07.s1 /CLONE=IMAGE:273253 /UG=Hs.211610 CUG triplet repeat, RNA-binding protein 2 /FL=gb:U69546.1 gb:AF036956.1 ~gb:AF090694.1 gb:NM 006561.1 ESTs, Consensus includes gb:R06655 /FEA=EST217546 at Moderately /DB XREF=gi:757275 similar to /DB XREF=est:yf10e02.r1 AF0788441 /CLONE=IMAGE:126458 /LTG=Hs.188518 hqp0376 proteinESTs, Moderately similar to AF078844 [H.sa iens h 0376 rotein H.sa iens hairless (mouse)018411.1 /DEF=Homo sapiens hairless220163 s_at gb:NM

homolog _ protein (putative single zinc finger transcription factor protein, responsible for autosomal recessive universal congenital alopecia, HR

gene) (HSA277165), mRNA. /FEA=mRNA

/GEN=HSA277165 /PROD=hairless protein lDB_XREF=gi:1103 6651 ILTG=Hs.2723 hairless protein (putative single zinc finger transcription factor protein, responsible for autosomal recessive universal congenital alo ecia, HR ene) /FL=gb:NM 018411.1 branched chainConsensus includes gb:NM_005504.1 214452 at aminotransferase/DEF=Homo Sapiens branched chain 1, cytosolic aminotransferase l, cytosolic (BCATl), mRNA.

/FEA=CDS /GEN=BCATl /PROD=branched chain aminotransferase 1, cytosolic !DB XI2EF=gi:5031606 lLJG=Hs.157205 branched chain aminotransferase 1, cytosolic /FL= b:U21551.1 b:NM 005504.1 pancreas- gb:NM 016341.1 /DEF=Homo Sapiens 205112 at enriched pancreas-enriched phospholipase C

phospholipase(LOC51196), mRNA. /FEA=mRNA
C

/GEN=LOC51196 IPROD~ancreas-enriched phospholipase C /DB XREF=gi:7705940 /UG=Hs.6733 pancreas-enriched phospholipase C /FL=gb:AF190642.2 gb:AF117948.1 b:NM 016341.1 prostaglandin-gb:NM 000963.1 /DEF=Homo Sapiens 204748 at endoperoxide prostaglandin-endoperoxide synthase synthase 2 (prostaglandin GH synthase and (prostaglandincyclooxygenase) (PTGS2), mRNA.

G/H synthase /FEA=mRNA /GEN=PTGS2 and /PROD=prostaglandin-endoperoxide synthase cyclooxygenase)2(prostaglandin GH synthase and cyclooxygenase) /DB XREF=gi:4506264 /UG=Hs.196384 prostaglandin-endoperoxide synthase 2 ( rostaglandin GH synthase and cyclooxygenase) /FL=gb:M90100.1 gb:L15326.1 gb:NM 00096 3.1 phosphatase _ 204054 at and 000314.1 /DEF=Homo Sapiens gb:NM

tensin homolog_ phosphatase and tensin homolog (mutated in (mutated in multiple advanced cancers 1) (PTEN), mRNA.

multiple /FEA=mRNA /GEN=PTEN

advanced cancers/PROD=phosphatase and tensin homolog 1) (mutated inmultiple advanced cancers 1) /DB XREF=gi:4506248 /UG=Hs.10712 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) lFL=gb:U92436.1 gb:U93051.1 gb:U96180.1 gb:NM 000314.1 retinoic acidConsensus includes gb:AI669229 221872 at /FEA=EST

receptor /DB XREF=gi:4834003 responder /DB XREF=est:WC13e06.x1 (tazarotene /CLONE=IMAGE:2315074 /UG=Hs.82547 induced) 1 retinoic acid receptor responder (tazarotene induced) 1 protease inhibitorgb:NM 002638.1 /DEF=Homo sapiens 203691 at protease 3, skin-derivedinhibitor 3, skin-derived (SI~ALP) (PI3), mRNA.

(SKALP) /FEA=mRNA /GEN=PI3 /PROD~rotease inhibitor 3, skin-derived (SI~ALP) /DB XREF=gi:4505786 /LTG=Hs.112341 protease inhibitor 3, skin-derived (SKALP) /FL= b:NM 002638.1 zinc finger gb:NM 003438.1 /DEF=Homo Sapiens 207394 at zinc protein 137 finger protein 137 (clone pHZ-30) (ZNF137), (clone pHZ-30)mRNA. /FEA=mRNA /GEN=ZNF137 /PROD=zinc finger protein 137 (clone pHZ-30) /DB XREF=gi:4507988 ILTG=Hs.151689 zinc finger protein 137 (clone pHZ-30) /FL=gb:NM_003438.1 gb:U09414.1 myosin, lightgb:NM 002477.1 /DEF=Homo sapiens 205145 s_at myosin, polypeptide light polypeptide 5, regulatory 5, (MYLS), mRNA.

regulatory /FEA=mRNA /GEN=MYLS /PROD=myosin, light polypeptide 5, regulatory JDB_XREF=gi:4505304 lUG=Hs.170482 myosin, light polypeptide 5, regulatory /FL=gb:L03785.1 gb:NM 002477.1 tumor necrosis000043.1 /DEF=Homo sapiens tumor 204781 s gb:NM at factor receptor_ 6 necrosis factor receptor superfamily, member superfamily, (TNFRSF6), mRNA. /FEA=mRNA

member 6 /GEN=TNFRSF6 /PROD=apoptosis (APO-1) antigen 1 /DB XREF=gi:4507582 /LTG=Hs.82359 tumor necrosis factor receptor superfamily, member 6 /FL=gb:M67454.1 gb:NM 000043.1 h othetical Consensus includes b:AI339568 /FEA=EST222727 s at protein /DB XREF=gi:4076495 FLJ22233 /DB XREF=est:qk67e10.x1 /CLONE=IMAGE:1874058 lUG=Hs.286194 hypothetical protein FLJ22233 /FL=gb:NM 024959.1 regenerating gb:AY007243.1 /DEF=Homo Sapiens 223447 at gene type regenerating gene type IV mRNA, IV complete cds. /FEA=mRNA /PROD=regenerating gene type IV /DB XREF=gi:12621025 /UG=Hs.105484 Homo sapiens regenerating gene type IV mRNA, complete cds /FL=gb:AY007243.1 Homo Sapiens Consensus includes gb:AK025615.1 225285 at cDNA: /DEF=Homo sapiens cDNA: FLJ21962 fis, FLJ21962 fis,clone HEP05564. IFEA=nlRNA

clone HEP05564/DB XREF=gi:10438186 /UG=Hs.7567 Homo sa iens cDNA: FLJ21962 fis, clone phosphoproteinConsensus includes gb:AK000680.1 225626 at associated /DEF=Homo Sapiens cDNA FLJ20673 With fis, glycosphingolipiclone KAIA4464. /FEA=mRNA

d-enriched /DB XREF=gi:7020924 lLTG=Hs.266175 microdomains phosphoprotein associated with GEMs /FL=gb:AF240634.1 gb:NM 018440.1 hypothetical Consensus includes gb:BF111925 226171 at iFEA=EST

protein /DB XREF=gi:10941704 FLJ20209 /DB XREF=est:7138gO5.x1 /CLONE=IMAGE:3523784 lUG=Hs.3685 hypothetical protein FLJ20209 Homo sapiens Consensus includes gb:AA532640 226484 at /FEA=EST

mRNA for /DB XREF=gi:2276894 KIAA1190 lDB_XREF=est:nj 17c04.s1 protein, partial/CLONE=IMAGE:986598 /LJG=Hs.206259 cds Homo sapiens mRNA for KIAA1190 protein, artial cds KIAA1543 Consensus includes gb:AB040976.1 226494 at protein /DEF=Homo sapiens mRNA for KIAA1543 protein, partial cds. JFEA~mRNA

/GEN=KIAA1543 /PROD=KIAA1543 protein /DB XREF=gi:7959352 /LTG=Hs.17686 KIAAl543 rotein hypothetical Consensus includes gb:AW138767 227180 at /FEA=EST

protein /DB XREF=gi:6143085 /DB XREF=est:UI-H-FLJ23563 BI1-aep-a-12-0-ULsl /CLONE=IMAGE:2719799 /UG=Hs.274256 hypothetical rotein FLJ23563 ESTs Consensus includes gb:AW264333 227320 at /FEA=EST

/DB XREF=gi:6641075 /DB XREF=est:x 98e01.x1 /CLONE=IMAGE:2758680 /UG=Hs.21835 ESTs ESTs Consensus includes gb:BF589359 227354 at /FEA=EST

/DB _X_RFF=gi:11681683 /DB XREF=est:nab25dOl.x1 /CLONE=IMAGE:3266737 /UG=Hs.13256 ESTs Homo Sapiens,Consensus includes gb:AW001287 227676_at /FEA=EST

Similar to /DB XREF=gi:5848203 RIKEN cDNA /DB XREF=est:wu27e06.x1 1810037020 /CLONE=IMAGE:2521282 /UG=Hs.61265 gene, clone ESTs, Weakly similar to G786_HCTMAN

MGC:21481 PROTEIN GS3786 H.sapiens IMAGE:385206 2, mRNA, com fete cds Homo sapiens Consensus includes gb:T86159 /FEA=EST227724 at cDNA: /DB XR.EF=gi:714511 FLJ22063 fis,/DB XREF=est:yd84h07.s1 clone HEP10326/CLONE=IMAGE:114973 /UG=Hs.10450 Homo sapiens cDNA: FLJ22063 fis, clone ESTs Consensus includes gb:AI700341 228653 at /FEA=EST

/DB XREF=gi:4988241 /DB XREF=est:wd06e1O.x1 /CLONE=IMAGE:2327370 /UG=Hs.110406 ESTs ESTs Consensus includes gb:BG494007 228716 at /FEA=EST

/DB XREF=gi:13455521 /DB XREF=est:602542289F1 !CLONE=IMAGE:4673182 /UG=Hs.203213 ESTs ESTs Consensus includes gb:AI559300 229331 at /FEA=EST

/DB XRFF=gi:4509505 /DB XREF=estaq43d03.,x1 /CLONE=IMAGE:2211557 /UG=Hs.294140 ESTs hypothetical Consensus includes gb:AI830823 229439 s /FEA=EST at protein /DB XREF=gi:5451416 lDB_~R.EF=est:wj52b06.x1 /CLONE=IMAGE:2406419 /UG=Hs.95549 by othetical rotein ESTs Consensus includes gb:BF431989 229657 at /FEA=EST

IDB_XREF=gi:11444103 /DB XREF=est:nab84a05.x1 /CLONE=IMAGE:3274280 /UG=Hs.203213 ESTs ESTs Consensus includes gb:BF589413 229893 at /FEA=EST

/DB XREF=gi:11681737 lDB_XREF=est:nab26b11.x1 /CLONE=IMAGE:3267020 /UG=Hs.55501 ESTs brain-specificConsensus includes gb:BG055052 230104 s_at /FEA=EST

protein p25 /DB XREF=gi:12512386 alpha /DB XREF=est:nac94g06.x1 /CLONE=IMAGE:3441995 /UG=Hs.29353 brain-s ecific rotein 25 al ha ESTs, Weakly Consensus includes gb:BF110588 230645 at /FEA=EST

similar to /DB XREF=gi:10940278 MMHUE4 fDB_XREF=est:7n39e12.x1 erythrocyte /CLONE=IMAGE:3567071 /UG=Hs.150478 membrane ESTs, Weakly similar to KIAA0987 protein protein 4.1, H.sapiens parent splice form [H.sa iens ESTs Consensus includes gb:BF592062 230760 at /FEA=EST

/DB XREF=gi:11684386 /DB XREF=est:7n98h06.x1 /CLONE=IMAGE:3 572962 ILJG=Hs.23 ESTs hepatocyte Consensus includes gb:AI032108 230914 at /FEA=EST

nuclear factor/DB_~~REF=gi:3250320 4, alpha /DB XREF=est:ow92dll.xl /CLONE=IMAGE:1654293 /UG=Hs.54424 hepatocyte nuclear factor 4, alpha ESTs Consensus includes gb:AW203959 230944 at /FEA=EST

/DB XREF=gi:6503431 /DB XREF=est:UI-H-BI 1-aeu-b-12-0-UI. s 1 !CLONE=IMAGE:2720590 /UG=Hs.149532 ESTs ESTs Consensus includes gb:AI139990 231022~at /FEA=EST

/DB XREF=gi:3647447 /DB XREF=est:qa47d03.x1 /CLONE=IMAGE:1689893 /UG=Hs.134586 ESTs ESTs Consensus includes gb:AI806131 231148 at /FEA=EST

/DB XREF=gi:5392697 lDB XREF=est:wf06c06.x1 /CLONE=IMAGE:2349802 /UG=Hs.99376 ESTs hypothetical Consensus includes gb:AB046810.1 232083 at protein /DEF=Homo Sapiens mRNA for KIAA1590 FLJ23045 protein, partial cds. /FEA=mRNA

/GEN=KIAA1590 /PROD=KIAA1590 protein /DB_~REF=gi:10047254 /LTG=Hs.141774 by othetical rotein FLJ23045 Homo Sapiens Consensus includes gb:AC004908 232641 at /DEF=Homo PAC clone Sapiens PAC clone RPS-855D21 /FEA=CDS

855D2 1 /DB XREF=gi:4156179 /UG=Hs.249181 Homo sa iens PAC clone RPS-855D21 putative Consensus includes gb:AJ251708.1 234669 x at microtubule- /DEF=Homo Sapiens partial mRNA
for putative binding proteinmicrotubule-binding protein. /FEA--mRNA

/PROD=putative microtubule-binding protein /DB XREF=gi:6491740 /UG=Hs.326544 utative microtubule-binding rotein ESTs Consensus includes gb:AI741469 234970 at /FEA=EST

/DB XREF=gi:5109757 /DB_~~REF=est:wgl lbOl.x1 /CLONE=IMAGE:2364745 /LJG=Hs.57787 ESTs ESTs Consensus includes gb:AI417897 235444 at /FEA=EST

/DB XRFF=gi:4261401 /DB XREF=estag55b06.x1 /CLONE=IMAGE:2112659 lUG=Hs.235860 ESTs ESTs Consensus includes gb:AI493909 235562 at /FEA=EST

/DB XR.EF=gi:4394912 /DB XREF=est:qz94e02.x1 /CLONE=IMAGE:2042234 /UG=Hs.6131 ESTs ESTs Consensus includes gb:AV741130 235651 at /FEA=EST

/DB XREF=gi:10858711 ~

/DB
XREF=est:AV741130 /CLONE=CBCATB06 /UG=Hs.173704 ESTs, Moderately similar to ALUB_HUMAN
ALU

SUBFAMILY SX SEQUENCE

CONTAMINATION WARNING ENTRY

H.sapiens ESTs Consensus includes gb:AW339510 235866 at /FEA=EST

/DB XREF=gi:6836136 /DB XREF=est:xz91h08.x1 /CLONE=IMAGE:2871615 /UG=Hs.42722 ESTs ESTs Consensus includes gb:AI076192 236422 at /FEA=EST

/DB XREF=gi:3405370 /DB XREF=est:oz01g07.x1 /CLONE=IMAGE:1674108 /UG=Hs.131933 ESTs ESTs Consensus includes gb:AL044570 236548 at /FEA=EST

/DB XREF=gi:5432785 /DB XREF=est:DKFZp434L082_s1 /CLONE=DKFZp434L082 fUG=Hs.147975 ESTs ESTs Consensus includes gb:AI733801 /FEA=EST237923 at /DB XREF=gi:5054914 /DB XREF=est:qk39c04.x5 /CLONE=IMAGE:1871334 /UG=Hs.146186 ESTs Homo Sapiens,Consensus includes gb:T69015 /FEA=EST238422 at clone /DB XREF=gi:680163 MGC:16402 /DB XREF=est:yc31f04.s1 IMAGE:394036 /CLONE=IMAGE:82303 /UG=Hs.192728 0, mRNA, ESTs com lete cds ESTs Consensus includes gb:AA502384 /FEA=EST238956 at _ /DB XREF=gi:2237351 /DB XREF=est:ne27fll.sl /CLONE=IMAGE:898605 /UG=Hs.151.529 ESTs ESTs Consensus includes gb:AI739241 /FEA=EST238984 at _ /DB XREF=gi:5101222 /DB XREF=est:wi14h02.x1 /CLONE=IMAGE:2390259 /UG=Hs.171480 ESTs ESTs Consensus includes gb:AA088446 /FEA=EST239065 at _ /DB XREF=gi:1633958 /DB XREF=est:z189f04.s1 /CLONE=IMAGE:511807 /UG=Hs.170298 ESTs ESTs Consensus includes gb:AI493046 /FEA=EST239148 at _ /DB XREF=gi:4394049 /DB XREF=est:qz49b04.x1 /CLONE=IMAGE:2030191 /UG=Hs.146133 ESTs ESTs Consensus includes gb:AI243098 /FEA=EST239966 at /DB XREF=gi:3838495 /DB XREF=est:qh26e03.x1 /CLONE=IMAGE:1845820 /UG=Hs.178398 ESTs Weakly Consensus includes gb:AI633523 /FEA=EST240106 at ESTs, _ similar to /DB XREF=gi:4684853 A49175 Motch /DB XREF=estah68b11.x1 B

protein - (CLONE=IMAGE:2123805 /LJG=Hs.44705 mouse M.musculus] ESTs betacellulin Consensus includes gb:AI620677 /FEA=EST241412 at _ /DB XREF=gi:4629803 lDB_XREF=estau85e09.x1 /CLONE=IMAGE:2257864 /UG=Hs.154191 ESTs ESTs Consensus includes gb:BF696216 /FEA=EST242626 at _ /DB XREF=gi:11981624 /DB XREF=est:602124536F1 /CLONE=IMAGE:4281632 lUG=Hs.l 88724 ESTs ESTs Consensus includes gb:N57929 /FEA=EST242978 x at lDB XRFF=gi:1201819 /DB XR.EF=est:yv61e06.s1 /CLONE=IMAGE:247234 /UG=Hs.48100 ESTs ESTs, Weakly Consensus includes gb:AI457984 243729 at /FEA=EST

similar to /DB XREF=gi:4312002 ALUl_HUMAN /DB XREF=estaj66a04.x1 ALU /CLONE=IMAGE:2146446 /UG=Hs.165900 SUBFAMILY ESTs, Weakly similar to ALUC_HUMAN
J ! ! ! !

SEQUENCE ALU CLASS C WARNING ENTRY ! ! !

CONTAMINAT H.sapiens ION WARNING

ENTRY

[H.sapiens) ESTs Consensus includes gb:AA581439 244650 at /FEA=EST

/DB XREF=gi:2359211 /DB XREF=est:nh13c10.s1 /CLONE=IMAGE:952242 lUG=Hs.152328 ESTs The two biomarker probe sets A and B were then combined, a total of 161 different probe sets, and the redundant polynucleotides were removed, representing 125 unique polynucleotides which are provided below in Table 4. The Table 4 polynucleotides are biomarkers of the invention.
TABLE 4 - Biomarkers Unigene Title Affymetrix Description Affymetrix And SEQ ID robe set NO:

3-hydroxy-3- gb:NM 005518.1 /DEF=Homo sapiens204607 3- at methylglutaryl- hydroxy-3-methylglutaryl-Coenzyme~
A

Coenzyme A synthase 2 (mitochondrial) (HMGCS2), synthase 2 mRNA. /FEA=mRNA /GEN=HMGCS2 (mitochondrial) /PROD=3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2(mitochondrial) SEQ ID NOS: /DB XREF=gi:5031750 /UG=Hs.59889 (DNA) and 126 hydroxy-3-methylglutaryl-Coenzyme A

(amino acid) synthase 2 (mitochondrial) /FL=gb:NM 005518.1 ATPase, Class Consensus includes gb:AW006935 214070 s at V, type lOB /FEA=EST /DB XREF=gi:5855713 /DB XREF=est:wt08bll.xl _47_ SEQ ID NO: 2 /CLONE=IMAGE:2506845 /UG=Hs.109358 (DNA) ATPase, Class V, a lOB

bone morphogeneticgb:NM 001200.1 /DEF=Homo sapiens 205290 s_at bone protein 2 morphogenetic protein 2 (BMP2), mRNA.

/FEA=mRNA IGEN=BMP2 /PROD=bone SEQ ID NOS: 3 morphogenetic protein 2 precursor (DNA) and 127 /DB XREF=gi:4557368 /UG=Hs.73853 bone (amino acid) morphogenetic protein 2 lFL=gb:NM 001200.1 brain-specific gb:NM 007030.1 /DEF=Homo sapiens 206179 s at protein brain-p25 alpha specific protein p25 alpha (p25), mRNA.

IFEA=mRNA /GEN~25 !PROD=brain-SEQ ID NOS: 4 specific protein p25 alpha (DNA) and 128 /DB XREF=gi:5902017 /LTG=Hs.29353 (amino acid) brain-specific protein p25 alpha /FL=gb:AB017016.1 gb:NM 007030.1 branched chain Consensus includes gb:NM 005504.1214452_at aminotransferase/DEF=Homo sapiens branched chain 1, cytosolic aminotransferase 1, cytosolic (BCAT1), mRNA. /FEA=CDS /GEN=BCAT1 SEQ ID NOS: 5 /PROD=branched chain aminotransferase 1, (DNA) and 129 cytosolic /DB XREF=gi:5031606 (amino acid) /LJG=Hs.157205 branched chain aminotransferase l, cytosolic /FL=gb:U21551.1 b:NM 005504.1 BTG family, membergb:NM 006763.1 /DEF=Homo Sapiens 201236 s_at BTG

2 family, member 2 (BTG2), mRNA.

/FEA=mRNA /GEN=BTG21PROD=BTG

SEQ ID NOS: 6 family, member 2 /DB XREF=gi:5802987 (DNA) and 130 /UG=Hs.75462 BTG family, member (amino acid) /FL=gb:U72649.1 gb:NM 006763.1 Carcinoembryonicgb:BC005008.1 /DEF=Homo sapiens, 203757 s_at antigen-related carcinoembryonic antigen-related cell cel1 adhesion moleculeadhesion molecule 6 (non-specific 6 cross (non-specific reacting antigen), clone MGC:10467, cross mRNA, reacting antigen)complete cds. /FEA=inRNA

/PROD=carcinoembryonic antigen-related SEQ ID NOS: 7 cell adhesionmolecule 6 (non-specific cross (DNA) and 131 reacting antigen) /DB XREF=gi:13477106 (amino acid) /LTG=Hs.73848 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) /FL=gb:BC005008.1 gb:M18216.1 gb:M29541.1 gb:NM
002483.1 caspase 10, apoptosis-gb:NM 001230.1 /DEF=Homo sapiens 205467 at related cysteinecaspase 10, apoptosis-related cysteine protease protease (CASP 10), mRNA. /FEA=mRNA

/GEN=CASP 10 /PROD=caspase 10, SEQ ID NOS: 8 a o tosis-related cysteine protease (DNA) and 132 /DB XREF=gi:4502568 /UG=Hs.5353 (amino acid) caspase 10, apoptosis-related cysteine rotease /FL=gb:U60519.1 gb:NM
001230.1 CUG triplet repeat,gb:NM 006561.1 /DEF=Homo sapiens202158 s at CUG

RNA-binding proteintriplet repeat, RNA-binding protein2 2 (CUGBP2), mRNA. /FEA=mRNA

/GEN=CUGBP2 /PROD=CUG triplet repeat, SEQ ID NOS: 9 RNA-binding protein 2 (DNA) and 133 /DB XREF=gi:5729815 lUG=Hs.211610 (amino acid) CUG triplet repeat, RNA-binding protein 2 /FL=gb:U69546.1 gb:AF036956.1 gb:AF090694.1 gb:NM 006561.1 cystatin S gb:NM 001899.1 /DEF=Homo sapiens206994 at cystatin S (CST4), mRNA. /FEA=mRNA

SEQ ID NOS: 10 /GEN=CST4 /PROD=cystatin S

(DNA) and 134 /DB XREF=gi:4503108 /LJG=Hs.56319 (amino acid) cystatin S /FL=gb:NM 001899.1 cystic fibrosis gb:NM 000492.2 JDEF=Homo sapiens205043 at cystic transmembrane fibrosis transmembrane conductance conductance regulator, ATP-binding cassette (sub-family regulator, ATP- C, member 7) (CFTR), mRNA.

binding cassette/FEA=mRNA /GEN=CFTR /PROD=cystic (sub-family C, memberfibrosis transmembrane conductanceregulator, 7) ATP-binding cassette (sub-family C, member SEQ ID NOS: 11 7) /DB XREF=gi:6995995 /UG=Hs.663 (DNA) and 135 cystic fibrosis transmembrane conductance (amino acid) regulator, ATP-binding cassette (sub-family C, member 7) /FL=gb:NM 000492.2 cytochrome P450,gb:NM 000775.1 /DEF=Homo sapiens205073 at subfamily IIJ cytochrome P450, subfamily IIJ
(arachidonic (arachidonic acid epoxygenase) polypeptide acid 2 (CYP2J2), epoxygenase) mRNA. /FEA=mRNA /GEN=CYP2J2 polypeptide 2 /PROD=cytochrome P450, subfamily IIJ

(arachidonic acidepoxygenase) polypeptide 2 SEQ ID NOS: 12 /DB XREF=gi:4503226 /LTG=Hs.152096 (DNA) and 136 cytochrome P450, subfamily IIJ
(arachidonic (amino acid) acid epoxygenase) polypeptide /FL=gb:U37143.1 b:NM 000775.1 dipeptidylpeptidasegb:M80536.1 /DEF=H.sapiens dipeptidyl203716 s at IV (CD26, adenosinepeptidase IV (DPP4) mRNA, complete cds.

deaminase /FEA=mRNA /GEN=DPP4 complexing protein/PROD=dipeptidyl peptidase IV
2) IDB_XREF=gi:181569 iLTG=Hs.44926 SEQ ID NOS 13 dipeptidylpeptidase IV (CD26, adenosine (DNA) and 137 deaminase complexing protein 2) (amino acid) /FL=gb:M80536.1 gb:NM 001935.1 DI~FZP434C091 Consensus includes gb:AL080170.1215047 at rotein /DEF=Homo sa iens mRNA; cDNA

DKFZp434C091 (from clone SEQ ID NO: 14 DKFZp434C091); partial cds. /FEA=mRNA

(DNA) /GEN=DKFZp434C091 /PROD=hypothetical protein /DB XREF=gi:5262639 /UG=Hs.51692 DKFZP434C091 rotein dopa decarboxylaseConsensus includes gb:AW772056 214347 s at (aromatic L-amino/FEA=EST /DB XREF=gi:7704118 acid decarboxylase)/DB XREF=est:hn64g06.x1 /CLONE=IMAGE:3032698 /LTG=Hs.150403 SEQ ID NO: 15 dopa decarboxylase (aromatic L-amino acid (DNA) decarboxylase) EphAl gb:NM 005232.1 /DEF=Homo Sapiens205977 s_at EphA 1 (EPHA 1 ), mRNA. /FEA=mRNA

SEQ ID NOS: 16 /GEN=EPHAl /PROD=EphAl (DNA) and 138 /DB XREF=gi:4885208 /LTG=Hs.89839 (amino acid) E hAl /FL=gb:M18391.1 gb:NM 005232.1 ESTs, ModeratelyConsensus includes gb:R06655 217546_at /FEA=EST

similar to AF078844/DB XREF=gi:757275 1 hqp0376 protein/DB XREF=est:yf10e02.r1 [H.sapiens] /CLONE=IMAGE:126458 /UG=Hs.188518 ESTs, Moderately similar to AF078844 SEQ ID NO: 17 hqp0376 protein H.sapiens (DNA) ESTs, Weakly Consensus includes gb:AW675655 222354 at similar to I38022 /FEA=EST /DB XREF=gi:7540890 hypothetical /DB XREF=est:ba52e01.x1 protein [H. sapiens] /CLONE=IMAGE:2900184 lUG=Hs.31415 ESTs SEQ ID NO: 18 (DNA) fibroblast growthgb:NM 022969.1 lDEF=Homo Sapiens203638 s at factor receptor fibroblast growth factor receptor 2 2 (bacteria-(bacteria-expressedexpressed kinase, keratinocyte growth factor kinase, keratinocytereceptor, craniofacial dysostosis 1, Crouzon~

growth factor syndrome, Pfeiffer syndrome, Jackson-Weiss receptor, craniofacialsyndrome) (FGFR2), transcript variant 2, dysostosis 1, mRNA. JFEA=mRNA IGEN=FGFR2 Crouzon syndrome, Pfeiffer/PROD=fibroblast growth factor receptor 2, syndxome, Jackson-isoform 2precursor /DB XREF=gi:13186252 Weiss syndrome) /UG=Hs.278581 fibroblast growth factor receptor 2 (bacteria-expressed kinase, SEQ ID NOS: 19 keratinocyte growth factor receptor, (DNA) and 139 craniofacial dysostosis 1, Crouzon syndrome, (amino acid) Pfeiffer syndrome, Jackson-Weiss syndrome) /FL=gb:NM 022969.1 gb:M97193.1 gb:M80634.1 FXYD domain- gb:BC005238.1 /DEF=Homo Sapiens,202489 s_at FXYD

containing ion domain-containing ion trans ort regulator 3, transport regulatorclone MGC:12265, mRNA, complete 3 cds.

/FEA=mRNA /PROD=FXYD domain-SEQ ID NOS: 20 containing ion transport regulator3 (DNA) and 140 /DB XREF=gi:13528881 /UG=Hs.301350 (amino acid) FXYD domain-containing ion transport regulator 3 /FL=gb:NM 005971.2 b:BC005238.1 G protein-coupledgb:AF062006.1 /DEF=Homo sapiens 210393 at orphan receptor 49 G protein-coupled receptor HG38 mRNA, complete cds. /FEA=mRNA /PROD=orphan SEQ ID NOS: 21 G protein-coupled receptor HG38 (DNA) and 141 /DB XREF=gi:3366801 /UG=Hs.285529 G

(amino acid) protein-coupled receptor 49 /FL=gb:AF062006.1 gb:AF061444.1 gb:NM 003667.1 hairless (mouse)gb:NM 018411.1 /DEF=Homo Sapiens 220163 s at homolog hairless protein (putative single zinc finger transcription factor protein, responsible for SEQ ID NOS: 22 autosomal recessive universal congenital (DNA) and 142 alopecia, HR gene) (HSA277165), mRNA.

(amino acid) /FEA=mRNA /GEN=HSA277165 /PROD=hairless protein /DB XREF=gi:11036651 /UG=Hs.272367 hairless protein (putative single zinc finger transcription factor protein, responsible for autosomal recessive universal congenital alo ecia, HR gene) /FL= b:NM 018411.1 hemoglobin, alphagb:BC005931.1 /DEF=Homo Sapiens, 211745 x at hemoglobin, alpha 2, clone MGC:14541, SEQ ID NOS: 23 mRNA, complete cds. /FEA=mRNA

(DNA) and 143 /PROD=hemoglobin, alpha 2 (amino acid) /DB XRFF=gi:13543547 /FL= b:BC005931.1 hemoglobin, alphaConsensus includes gb:T50399 /FEA=EST.214414 x at /DB XREF=gi:652259 SEQ ID NO: 24 /DB XREF=est:yb30b1 l.sl (DNA) l CLONE=IMAGE:72669 I UG=Hs.251577 hemo lobin, al ha 1 heparanase gb:NM_006665.1 /DEF=Homo Sapiens 219403 s_at heparanase (HPSE), mRNA. /FEA=mRNA

SEQ ID NOS: 25 /GEN=HPSE /PROD=heparanase (DNA) and 144 /DB XREF=gi:5729872 /UG=Hs.44227 (amino acid) heparanase /FL=gb:AF165154.1 gb:AF152376.1 gb:NM_OQ6665.1 gb:AF084467.1 gb:AF155510.1 Pudlak Consensus includes gb:AL022313 217354 s at Hermansky- _ syndrome /DEF=Human DNA sequence from clone RPS-1119A7 an chromosome 22 12.2-12.3 SEQ ID NOS: 26 Contains the TXN2 gene for mitochondria) (DNA) and 145 thioredoxin, a novel gene, the EIF3S7 gene (amino acid) for eukaryotic translation initiation factor 3 subunit 7 (zeta, 6667kD) (EIF3-P66), the gene f... /FEA=CDS_3 /DB XREF=gi:4200326 /UG=Hs.272270 Human DNA sequence from clone 1119A7 on chromosome 22q12.2-12.3 Contains the TXN2 gene for mitochondria) thioredoxin, a novel gene, the EIF3S7 gene for eukaryotic translation initiation factor 3 subunit 7 (zeta, 6667kD) (EIF3-P66), the gene for a nov HERV-H LTR- gb:NM 007072.1 /DEF=Homo Sapiens 220812 s_at associating 2 HERV-H LTR-associating 2 (HHLA2), mRNA. /FEA=mRNA /GEN=HHLA2 SEQ ID NOS: 27 /PROD=HERV-H LTR-associating 2 (DNA) and 146 /DB XREF=gi:5901963 /LTG=Hs.252351 (amino acid) HERV-H LTR-associating 2 /FL=gb:AF126162.1 b:NM 007072.1 Homo Sapiens Consensus includes gb:AW593996 213256 at clone 24707 mRNA /FEA=EST /DB X_RFF=gi:7281254 sequence /DB XREF=est:hg41g06.x1 /CLONE=IMAGE:2948218 /UG=Hs.124969 SEQ ID NO: 28 Homo Sapiens clone 24707 mRNA
sequence (DNA) Homo sapiens Consensus includes gb:AL049983.1 217288 at mRNA; cDNA /DEF=Homo sapiens mRNA; cDNA

DI~FZp564D042 DI~FZp564D042 (from clone (from clone DI~.FZp564D042). /FEA=mRNA

DI~F'Zp564D042) !DB_~~REF=gi:4884234 /UG=Hs.244136 Homo Sapiens mRNA; cDNA

SEQ ID NO: 29 DKFZp564D042 (from clone (DNA) DKFZp564D042) hypothetical gb:NM 017640.1 /DEF=Homo Sapiens 219573 at protein FLJ20048 hypothetical protein FLJ20048 (FLJ20048), mRNA. /FEA=mRNA /GEN=FLJ20048 SEQ ID NOS: 30 /PROD=hypothetical protein FLJ20048 (DNA) and 147 /DB XREF=gi:8923056 /UG=Hs.116470 (amino acid) hypothetical protein FLJ20048 /FL=gb:NM 017640.1 hypothetical gb:NM 017655.1 /DEF=Homo Sapiens 219970 at protein FLJ20075 hypothetical protein FLJ20075 (FLJ20075), mRNA. /FEA=mRNA /GEN=FLJ20075 SEQ ID NOS: 31 /PROD=hypothetical protein FLJ20075 (DNA) and 148 /DB XREF=gi:8923083 lUG=Hs.205058 (amino acid) hypothetical protein FLJ20075 /FL=gb:NM 017655.1 interferon consensusConsensus includes gb:AI073984 204057 at /FEA=EST

sequence bindingIDB_XREF=gi:3400628 protein 1 /DB XREF=est:oy66cO5.x1 /CLONE=IMAGE:1670792 /UG=Hs.14453 SEQ ID NO: 32 interferon consensus.sequence binding protein (DNA) 1 /FL=gb:M91196.1 gb:NM 002163.1 KIAA0690 proteinConsensus includes gb:AK000238.1216360 x at /DEF=Homo Sapiens cDNA FLJ20231 fis, SEQ ID NO: 33 clone COLF5511, highly similar to (DNA) AB014590 Homo sapiens mRNA for I~IAA0690 protein. /FEA=mRNA

/DB_~REF=gi:7020188 /L1G=Hs.60103 I~IAA0690 protein matrilin 3 . gb:NM_002381.2 /DEF=Homo Sapiens206091 at matrilin 3 (MATN3) precursor, mRNA.

SEQ ID NOS: 34 /FEA~nRNA /GEN=MATN3 (DNA) and 149 /PROD=matrilin 3 precursor (aanino acid) !DB ~~REF=gi:13518040 !UG=Hs.278461 matrilin 3 /FL=gb:NM 002381.2 metastasis-associatedgb:NM 004739.1 /DEF=Homo Sapiens203444 s at 1-like 1 metastasis-associated 1-like 1 (MTA1L1), mRNA. /FEA=mRNA /GEN=MTA 1 L

SEQ ID NOS: 35 /PROD=metastasis-associated 1-like (DNA) and 150 /DB XREF=gi:4758739 /LTG=Hs.173043 (amino acid) metastasis-associated 1-like /FL=gb:AB016591.1 gb:NM 004739.1 gb:AF295807.1 mucin 2, gb:NM 002457.1 /DEF=Homo Sapiens204673 at mucin intestinal/tracheal2, intestinaltracheal (MUC2), mRNA.

/FEA=mRNA /GEN=MUC2 /PROD=mucin SEQ ID NOS: 36 2, intestinaltracheal /DB XREF=gi:4505284 (DNA) and 151 /UG=Hs.315 mucin 2, intestinaltracheal (amino acid) /FL=gb:NM 002457.1 gb:L21998.1 mucin 3B Consensus includes gb:AB038783.1214898 x at /DEF=Homo sapiens MUC3B mRNA
for SEQ ID NOS: 37 intestinal mucin, partial cds.
/FEA=mRNA

(DNA) and 152 /GEN=MUC3B /PROD=intestinal mucin (amino acid) /DB XREF=gi:9929917 /UG=Hs.129782 mucin 3A, intestinal myosin, heavy gb:NM_003802.1 /DEF=Homo sapiens208208 at polypeptide 13, myosin, heavy polypeptide 13, skeletal skeletal muscle muscle (MYH13), mRNA. /FEA=mRNA

/GEN=MYH13 /PROD=myosin, heavy SEQ ID NOS: 38 polypeptide 13, skeletal muscle (DNA) and 153 /DB XREF=gi:11321578 /UG=Hs.278488 (amino acid) myosin, heavy polypeptide 13, skeletal muscle /FL=gb:NM 003802.1 b:AF111782.2 myosin, light gb:NM 002477.1 /DEF=Homo Sapiens 205145 s at polypeptide 5, myosin, light polypeptide 5, regulatory regulatory (MYLS), mRNA. /FEA=mRNA

/GEN=MYLS /PROD=myosin, light SEQ ID NOS: 39 polypeptide 5, regulatory , (DNA) and 154 /DB XREF=gi:4505304 /UG=Hs.170482 (amino acid) myosin, light polypeptide 5, regulatory lFL=gb:L03785.1 gb:NM 002477.1 nuclear receptorgb:NM_000901.1 /DEF=Homo sapiens 205259 at subfamily 3, nuclear receptor subfamily 3, group C, group C, member 2 member 2 (NR3C2), mRNA. /FEA=mRNA

/GEN NR3C2 /PROD=nuclear receptor SEQ ID NOS: 40 subfamily 3, group C, member 2 (DNA) and 155 /DB XREF=gi:4505198 lUG=Hs.1790 (amino acid) nuclear receptor subfamily 3, group C, member 2 /FL=gb:M16801.1 gb:NM 000901.1 nuclear receptorConsensus includes gb:AF228413.1 210174 at subfamily 5, /DEF=Homo Sapiens hepatocyte transcription group A, member 2 factor mRNA, 3UTR. /FEA=mRNA

lDB_XREF=gi:7677372 /LTG=Hs.183123 SEQ ID NOS: 41 nuclear receptor subfamily 5, group A, (DNA) and 156 member 2 /FL=gb:U93553.1 gb:AB019246.1 (amino acid) gb:AF124247.1 pancreas-enrichedgb:NM 016341.1 /DEF=Homo sapiens 205112 at phospholipase pancreas-enriched phospholipase C C

(LOC51196), mRNA. IFEA=mRNA

SEQ ID NOS: 42 /GEN=LOC51196 /PROD=pancreas-enriched (DNA) and 157 phospholipase C /DB XREF=gi:7705940 (amino acid) /UG=Hs.6733 pancreas-enriched phospholipase C /FL=gb:AF190642.2 gb:AF117948.1 gb:NM 016341.1 peroxisomal trapsgb:NM_018441.1 /DEF=Homo sapiens 221142 s_at enoyl CoA reductase;peroxisomal traps 2-enoyl CoA
reductase;

putative short putative short chain alcohol dehydrogenase chain alcohol (HSA250303), mRNA. /FEA=mRNA

dehydrogenase /GEN=HSA250303 !PROD=peroxisomal traps 2-enoyl CoA reductase;putative short SEQ ID NOS: 43 chain alcohol dehydrogenase (DNA) and 158 /DB XREF=gi:8923751 !UG=Hs.281680 (amino acid) peroxisomal traps 2-enoyl CoA
reductase;

putative short chain alcohol dehydrogenase /FL=gb:NM 018441.1 phosducin gb:M33478.1 /DEF=Human 33-kDa 211496 s_at phototransducing protein mRNA, complete SEQ ID NOS: 44 cds. IFEA=mRNA /DB XREF=gi:1771.86 (DNA) and 159 /LTG=Hs.550 phosducin (amino acid) /FL= b:NM 022577.1 b:M33478.1 b:AF076465.1 phosphatase and gb:NM 000314.1 /DEF=Homo sapiens204054 at tensin homolog phosphatase and tensin homolog (mutated in (mutated in multiplemultiple advanced cancers 1) (PTEN), advanced cancersmRNA. /FEA=mRNA IGEN=PTEN
1) /PROD=phosphatase and tensin homolog SEQ ID NOS: 45 (mutated inmultiple advanced cancers 1) (DNA) and 160 lDB XREF=gi:4506248 lUG=Hs.10712 (amino acid) phosphatase and tensin homolog (mutated in multiple advanced cancers 1) /FL=gb:U92436.1 gb:U93051.1 gb:U96180.1 gb:NM 000314.1 potassium channel,gb:U90065.1 /DEF=Human potassium204678 s at subfamily K, channel KCNO1 mRNA, complete member cds.

1 (TWIK-1) /FEA=mRNA /PROD=potassium channel KCNOl /DB XREF=gi:1916294 SEQ ID NOS: 46 /UG=Hs.79351 potassium channel, subfamily (DNA) and 161 K, member 1 (TWIK-1) /FL=gb:U33632.1 amino acid) b:U90065.1 b:U76996.1 b:NM_002245.1 prostaglandin- gb:NM 000963.1 /DEF=Homo sapiens204748 at endoperoxide prostaglandin-endoperoxide synthase2 synthase 2 (prostaglandin GH synthase and (prostaglandin cyclooxygenase) (PTGS2), mRNA.
G/H

synthase and /FEA=mRNA IGEN=PTGS2 cyclooxygenase) /PROD=prostaglandin-endoperoxide synthase 2(prostaglandin GH synthase and SEQ ID NOS: 47 cyclooxygenase) /DB XREF=gi:4506264 (DNA) and 162 /UG=Hs.196384 prostaglandin-endoperoxide (amino acid) synthase 2 (prostaglandin GH
synthase and cyclooxygenase) /FL=gb:M90100.1 gb:L15326.1 gb:NM 000963.1 protease inhibitorgb:NM 002638.1 /DEF=Homo Sapiens203691 at 3, skin-derived protease inhibitor 3, skin-derived (SKALP) (SKALP) (PI3), mRNA. IFEA=mRNA lGEN=PI3 /PROD~rotease inhibitor 3, skin-derived SEQ ID NOS: 48 (SKALP) /DB XREF=gi:4505786 (DNA} and 163 /UG=Hs.112341 protease inhibitor 3, skin-(amino acid) derived (SKALP) /FL=gb:NM 002638.1 PTPRF interactingConsensus includes gb:AI692180 212841 s_at /FEA=EST

protein, binding/DB XREF=gi:4969520 protein 2 (liprin/DB XREF=est:wd37f06.x1 beta 2) /CLONE=IMAGE:2330339 /LTG=Hs.12953 PTPRF interacting protein, binding protein 2 SEQ ID NO: 49 (liprin beta 2) (DNA) retinoic acid Consensus includes gb:AI669229 221872 at receptor IFEA=EST

responder (tazarotene/DB XREF=gi:4834003 induced) 1 /DB XREF=est:wc13e06.x1 /CLONE=IMAGE:2315074 /UG=Hs.82547 SEQ TD NO: 50 retinoic acid receptor responder (tazarotene (DNA) induced) 1 Rho GTPase 015366.1 /DEF=Homo sapiens Rho 205980 s gb:NM at activating protein_ 8 GTPase activating protein 8 (ARHGAPB), mRNA. IFEA=mRNA /GEN=ARHGAP8 SEQ ID NOS: 51 /PROD=Rho GTPase activating protein (DNA) and 164 /DB XREF=gi:7656903 /UG=Hs.102336 (amino acid) Rho GTPase activating protein /FL= b:NM 015366.1 ribonuclease, gb:NM 002933.1 /DEF=Homo sapiens 201785 at RNase A family, 1 ribonuclease, RNase A family, ) 1 (pancreatic (pancreatic) (RNASE 1 ), mRNA. /FEA=mRNA

/GEN=RNASEl /PROD=ribonuclease, SEQ ID NOS: 52 RNase A family, 1 (pancreatic) (DNA) and 165 /DB XREF=gi:4506546 /UG=Hs.78224 (amino acid) ribonuclease, RNase A family, 1 (pancreatic) /FL=gb:BC005324.1 gb:NM 002933.1 gb:D26129.1 serine (or cysteine)gb:NM 002639.1 /DEF=Homo Sapiens 204855 at serine proteinase inhibitor,(or cysteine) proteinase inhibitor,B
Glade Glade B (ovalbumin),(ovalbumin), member 5 (SERPINBS), member 5 mRNA. /FEA=mRNA /GEN=SERP1NB5 /PROD=serine (or cysteine) proteinase SEQ ID NOS: 53 inhibitor, cladeB (ovalbuxnin), member 5 (DNA) and 166 /DB XREF=gi:4505788 /UG=Hs.55279 (amino acid) serine (or cysteine) proteinase inhibitor, Glade B (ovalbumin), member 5 /FL=gb:NM 002639.1 gb:U04313.1 spondin 1, (f Consensus includes gb:AI885290 213994 s spondin) /FEA=EST at extracellular /DB XREF=gi:5590454 matrix protein /DB XREF=est:w192a04.x1 /CLONE=IMAGE:2432334 /UG=Hs.5378 SEQ ID NO: 54 spondin l, (f spondin) extracellular matrix (DNA) rotein superoxide dismutasegb:NM 003102.1 /DEF=Homo sapiens 205236 x at 3, extracellularsuperoxide dismutase 3, extracellular (SOD3), mRNA. /FEA=mRNA /GEN=SODS

SEQ ID NOS: 55 /PROD=superoxide dismutase 3, extracellular (DNA) and 167 lDB_XREF=gi:4507150 /UG=Hs.2420 (amino acid) superoxide dismutase 3, extracellular /FL=gb:J02947.1 gb:NM 003102.1 tumor necrosis gb:BC002794.1 /DEF=Homo Sapiens, 209354 at factor tumor receptor superfamily,necrosis factor receptor superfamily, member member 14 14 (herpesvirus entry mediator), clone (herpesvirus MGC:3753, mRNA, complete Gds.
entry mediator) lFEA=mRNA /PROD=tumor necrosis factor rece for su erfamily,member 14 (he esvirus SEQ ID NOS: 56 entry mediator) /DB XREF=gi:12803894 (DNA) and 168 !UG=Hs.279899 tumor necrosis factor (amino acid) receptor superfamily, member 14 (herpesvirus entry mediator) /FL=gb:BC002794.1 gb:U70321.1 gb:U81232.1 gb:NM
003820.1 gb:AF153978.1 tumor necrosis gb:NM 000043.1 /DEF=Homo Sapiens204781 s at factor tumor receptor superfamily,necrosis factor receptor superfamily, member member 6 6 (TNFRSF6), mRNA. /FEA=mRNA

/GEN=TNFRSF6 /PROD=apoptosis (APO-1) SEQ ID NOS: 57 antigen 1 /DB XREF=gi:4507582 (DNA) and 169 /LJG=Hs.82359 tumor necrosis factor receptor (amino acid) superfamily, member 6 /FL=gb:M67454.1 b:NM 000043.1 zinc finger proteingb:NM 003438.1 /DEF=Homo sapiens20?394 at zinc 137 (clone pHZ-30)finger protein 137 (clone pHZ-30) (ZNF137), mRNA. /FEA=mRNA /GEN=ZNF 13 7 SEQ ID NOS: 58 /PROD=zinc finger protein 137 (clone pHZ-(DNA) and 170 30) /DB XREF=gi:4507988 /LTG=Hs.151689 (amino acid) zinc finger protein 137 (clone pHZ-30) /FL=gb:NM 003438.1 gb:U09414.1 hypothetical Consensus includes gb:AI339568 222727 s_at protein /FEA=EST

FLJ22233 /DB XREF=gi:4076495 /DB XREF=est:qk67e10.x1 SEQ ID NO: 59 /CLONE=IMAGE:1874058 /UG=Hs.286194 (DNA) hypothetical protein FLJ22233 /FL= b:NM 024959.1 regenerating gb:AY007243.1 /DEF=Homo Sapiens 223447 at gene type IV regenerating gene type IV mRNA, complete cds. /FEA=mRNA /PROD=regenerating gene SEQ ID NOS: 60 type IV /DB XREF=gi:12621025 (DNA) and 171 /LTG=Hs.105484 Homo Sapiens regenerating (amino acid) gene type IV mRNA, complete cds !FL=gb:AY007243.1 Homo sapiens Consensus includes gb:AK025615.1225285 at cDNA:

FLJ21962 fis, /DEF=Homo Sapiens cDNA: FLJ21962 clone fis, HEP05564 clone HEP05564. /FEA=mRNA

/DB XREF=gi:10438186 /UG=Hs.7567 SEQ ID NO: 61 Homo sapiens cDNA: FLJ21962 fis, clone (DNA) HEP05564 ESTs Consensus includes gb:N37023 225407 at IFEA=EST

/DB XREF=gi:1158165 SEQ ID NO: 62 1DB XREF=est:yy40d03.s1 (DNA) /CLONE=IMAGE:273701 /UG=Hs.235883 ESTs phosphoprotein Consensus includes gb:AI~000680.1225626 at associated with /DEF=Homo sapiens cDNA FLJ20673 fis, lycos hin oli clone I~AAIA4464. /FEA=mRNA
id-enriched /DB XREF=gi:7020924 /UG=Hs.266175 microdomains phosphoprotein associated with GEMS

/FL=gb:AF240634.1 gb:NM_018440.1 SEQ ID NOS: 63 (DNA) and 172 (amino acid) prostate cancer Consensus includes gb:AA633076 226167 at /FEA=EST

associated proteinlDB_XREF=gi:2556490 /DB XREF=est:nq38a06.s1 SEQ ID NO: 64 /CLONE=IMAGE:1146130 /UG=Hs.27495 (DNA) rostate cancer associated rotein Homo Sapiens, Consensus includes gb:AA524690 226168 at /FEA=EST

Similar to RIKEN/DB XREF=gi:2265618 cDNA 1110060018 /DB XREF=est:ng38e07.s1 gene, clone /CLONE=IMAGE:937092 /UG=Hs.294143 MGC:17236 ESTs, Weakly similar to predicted using IMAGE:3864137, Genefinder C.elegans mRNA, complete cds SEQ ID NO: 65 (DNA) hypothetical Consensus includes gb:BF111925 226171 at protein /FEA=EST

FLJ20209 /DB XREF=gi:10941704 /DB XREF=est:7138gO5.x1 SEQ ID NO: 66 /CLONE=IMAGE:3523784 /UG=Hs.3685 (DNA) h othetical rotein FLJ20209 Homo sapiens Consensus includes gb:AA532640 226484 at mRNA /FEA=EST

for KIAA1190 /DB XREF=gi:2276894 .

protein, partial/DB XREF=est:nj 17c04.s1 cds /CLONE=IMAGE:986598 /UG=Hs.206259 SEQ ID NOS: 67 Homo Sapiens mRNA for KIAA1190 protein, (DNA) and 173 partial cds (amino acid) KIAA1543 proteinConsensus includes gb:AB040976.1226494 at /DEF=Homo sapiens mRNA for KIAA1543 SEQ ID NOS: 68 protein, partial cds. /FEA=mRNA

(DNA) and 174 /GEN=KIAA1543 /PROD=KIAA1543 (amino acid) protein lDB_XREF=gi:7959352 /UG=Hs.17686 KIAA1543 protein hypothetical Consensus includes gb:AK002203.1226992_at protein MGC20702 /DEF=Homo Sapiens cDNA FLJ11341 fis, clone PLACE1010786. /FEA=mRNA

SEQ ID NO: 69 /DB XREF=gi:7023932 /UG=Hs.10260 (DNA) Homo sapiens cDNA FLJ11341 fis, clone Homo Sapiens Consensus includes gb:AA129774 227019 at cDNA /FEA=EST

FLJ13137 fis, /DB XREF=gi:1690185 clone NT2RP3003150 /DB XREF=est:z116h09.s1 /CLONE=IMAGE:502145 /UG=Hs.288905 SEQ ID NO: 70 Homo sapiens cDNA FLJ13137 fis, clone (DNA) NT2RP3003150 hypothetical Consensus includes gb:AW138767 227180 at protein FLJ23563 /FEA=EST /DB XREF=gi:6143085 /DB_XREF=est:UI-H-BI1-aep-a-12-0-UI.
s 1 SEQ ID NO: 71 /CLONE=IMAGE:2719799 /UG=Hs.274256 (DNA) h othetical protein FLJ23563 ESTs Consensus includes gb:AW264333 227320 at /FEA=EST /DB _X_RFF=gi:6641075 SEQ ID NO: 72 /DB XREF=est:xq98e01.x1 (DNA) !CLONE=IMAGE:2758680 !UG=Hs.21835 ESTs ESTs Consensus includes gb:BF589359 227354 at /FEA=EST

/DB XREF=gi:11681683 SEQ ID NO: 73 /DB XREF=est:nab25dOl.xl (DNA) /CLONE=IMAGE:3266737 /UG=Hs.13256 ESTs Homo sapiens, Consensus includes gb:AW001287 227676 at Similar to RII~EN/FEA=EST /DB XREF=gi:5848203 cDNA 1810037020 lDB_XREF=est:wu27e06.x1 gene, clone /CLONE=IMAGE:2521282 /UG=Hs.61265 MGC:21481 ESTs, Weakly similar to G786_HUMAN

IMAGE:3852062, PROTEIN GS3786 H.sapiens mRNA, complete cds SEQ ID NO: 74 (DNA) ESTs, Weakly Consensus includes gb:AA557324 227702 at similar /FEA=EST

to JX0331 laurate/DB XREF=gi:2327801 omega-hydroxylase/DB XREF=est:n181a02.s1 [H.sapiens] /CLONE=IMAGE:1057034 /UG=Hs.26040 ESTs, Weakly similar to fatty acid omega-SEQ ID NO: 75 hydroxylase H.sapiens (DNA) Homo Sapiens Consensus includes gb:T86159 227724 at cDNA: /FEA=EST

FLJ22063 fis, /DB XREF=gi:714511 clone HEP10326 /DB XREF=est:yd84h07.s1 /CLONE=IMAGE:114973 /UG=Hs.10450 SEQ ID NO: 76 Homo Sapiens cDNA: FLJ22063 fis, clone (DNA) HEP 10326 GalNAc alpha-2, Consensus includes gb:Y11339.2 227725 at sialyltransferase/DEF=Homo Sapiens mRNA for GalNAc I, long form alpha-2, 6-sialyltransferase I, long form.

/FEA=mRNA /PROD=GaINAc alpha-2,6-SEQ ID NOS: 77 sialyltransferase I /DB XREF=gi:7576275 (DNA) and 175 1UG=Hs.105352 GaINAc alpha-2, (amino acid) sialyltransferase I, long form ESTs, Weakly Consensus includes gb:AI827789 228241 at similar /FEA=EST

to JE0350 Anterior!DB XREF=gi:5448449 gradient-2 /DB XREF=est:wf33a07.x1 [H.sapiens] /CLONE=IMAGE:2357364 /LTG=Hs.100686 ESTs, Weakly similar to JE0350 Anterior SEQ ID NO: 78 gradient-2 H.sapiens (DNA) ESTs Consensus includes gb:AI700341 228653 at /FEA=EST

/DS ~~REF=gi:4988241 SEQ ID NO: 79 /DB XREF=est:wd06e10.x1 (DNA) /CLONE=IMAGE:2327370 /UG=Hs.110406 ESTs ESTs Consensus includes gb:BG494007 228716 at /FEA=EST

/DB XREF=gi:13455521 SEQ ID NO: 80 /DB XREF=est:602542289F1 (DNA) , /CLONE=IMAGE:4673182 /LTG=Hs.203213 ESTs anterior gradientConsensus includes gb:AI922323 228969 at 2 /FEA=EST

(Xenepus laevis)/DB XREF=gi:5658287 homolog /DB XREF=est:wn90h03.x1 /CLONE=IMAGE:2453141 !UG=Hs.293380 SEQ ID NO: 81 ESTs (DNA) Homo sapiens Consensus includes gb:AK026984.1229021 at cDNA:

FLJ23331 fis, /DEF=Homo sapiens cDNA: FLJ23331 clone fis, HEP 12664 clone HEP 12664. /FEA=mRNA

/DB XREF=gi:10439980 /UG=Hs.50742 SEQ ID N0: 82 Homo Sapiens cDNA: FLJ23331 fis, clone (DNA) HEP 12664 ESTs Consensus includes gb:AI559300 229331 at IFEA=EST

/DB XREF=gi:4509545 SEQ ID N0: 83 /DB XREF=estaq43d03.x1 (DNA) /CLONE=IMAGE:2211557 /UG=Hs.294140 ESTs hypothetical Consensus includes gb:AI830823 229439 s at protein /FEA=EST

/DB XREF=gi:5451416 SEQ ID NO: 84 !DB XREF=est:wj52b06.x1 (DNA) /CLONE=IMAGE:2406419 /UG=Hs.95549 by othetical rotein ESTs Consensus includes gb:BF431989 229657 at /FEA=EST

/DB XREF=gi:11444103 SEQ ID N0: 85 /DB XREF=est:nab84a05.x1 (DNA) /CLONE=IMAGE:3274280 ILTG=Hs.203213 ESTs ESTs Consensus includes gb:BF589413 229893 at /FEA=EST

/DB XREF=gi:11681737 SEQ ID NO: 86 /DB XREF=est:nab26b11.x1 (DNA) /CLONE=IMAGE:3267020 /UG=Hs.55501 ESTs brain-specific Consensus includes gb:BG055052 230104_s_at protein /FEA=EST

p25 alpha /DB XREF=gi:12512386 /DB XREF=est:nac94g06.x1 SEQ ID NO: 87 /CLONE=IMAGE:3441995 /UG=Hs.29353 (DNA) brain-s ecific rotein 25 al ha Weakly similar Consensus includes gb:BF110588 230645 at ESTs /FEA=EST
, to MMHUE4 /DB XREF=gi:10940278 erythrocyte /DB XREF=est:7n39e12.x1 membrane protein/CLONE=IMAGE:3567071 /UG=Hs.150478 4.1, parent spliceESTs, Weakly similar to KIAA0987 protein form [H.sapiens]H.sapiens SEQ ID NO: 88 (DNA) ESTs Consensus includes gb:BF592062 230760 at /FEA=EST _ /DB XREF=gi:11684386 SEQ ID NO: 89 /DB XREF=est:7n98h06.x1 (DNA) /CLONE=IMAGE:3572962 /UG=Hs.233890 ESTs nuclear Consensus includes gb:AI032108 230914 at hepatocyte /FEA=EST _ factor 4, alpha /DB XREF=gi:3250320 /DB XREF=est:ow92dll.xl SEQ D~ NO: 90 (CLONE=IMAGE:1654293 lUG=Hs.54424 (DNA) hepatocyte nuclear factor 4, alpha ESTs Consensus includes gb:AW203959 230944 at /FEA=EST /DB XREF=gi:6503431 SEQ ID NO: 91 /DB_XREF=est:UI-H-BI1-aeu-b-12-0-ULsl (DNA) /CLONE=IMAGE:2720590 /UG=Hs.149532 ESTs ESTs Consensus includes gb:AI139990 231022 at /FEA=EST _ /DB ~~REF=gi:3647447 SEQ ID NO: 92 /DB XREF=est:qa47d03.x1 (DNA) /CLONE=IMAGE:1689893 /UG=Hs.134586 ESTs ESTs Consensus includes gb:AI806131 231148 at /FEA=EST _ /DB XREF=gi:5392697 SEQ ID NO: 93 /DB XREF=est:wf06c06.x1 (DNA) /CLONE=IMAGE:2349802 /UG=Hs.99376 ESTs hypothetical Consensus includes gb:AB046810.1 232083 at protein FLJ23045 /DEF=Homo sapiens mRNA for KIAA1590 protein, partial cds. /FEA=mRNA

SEQ ID NO: 94 /GEN=KIAA1590 /PROD=KIAA1590 (DNA) protein /DB XREF=gi:10047254 /UG=Hs.101774 hypothetical protein Homo sa iens Consensus includes gb:AK026404.1 232321 at cDNA:

FLJ22751 fis, /DEF=Homo sapiens cDNA: FLJ22751 clone fis, I~AIA0483, highlyclone KAIA0483, highly similar to AF016692 similar to AF016692Homo sapiens small intestinal mucin (MUC3) Homo sapiens mRNA. /FEA~nRNA
small intestinal mucin/DB XREF=gi:10439257 /LJG=Hs.271819 (MLTC3) mRNA Homo sapiens cDNA: FLJ22751 fis, clone I~AIA0483, highly similar to SEQ ID NO: 95 Homo sapiens small intestinal mucin (MUC3) (DNA) mRNA

Homo Sapiens Consensus includes gb:AC004908 232641 at PAC

clone RP5-855D21/DEF=Homo Sapiens PAC clone RP5-855D21 /FEA=CDS_3 SEQ ID NOS: 96 /DB XREF=gi:4156179 /LJG=Hs.249181 (DNA), 176 (aminoHomo Sapiens PAC clone RP5-855D21 acid), 177 (amino acid), and 178 (amino acid) putative microtubule-Consensus includes gb:AJ251708.1234669 x at binding protein /DEF=Homo Sapiens partial mRNA
for putative microtubule-binding protein.

SEQ ID NO: 97 /FEA=mRNA /PROD=putative microtubule-(DNA) binding protein /DB XREF=gi:6491740 /UG=Hs.326544 putative microtubule-binding rotein ESTs Consensus includes gb:AI741469 234970 at /FEA=EST

/DB XREF=gi:5109757 SEQ ID NO: 98 /DB XREF=est:wgllbOl.x1 (DNA) /CLONE=IMAGE:2364745 /UG=Hs.57787 ESTs ESTs Consensus includes gb:AI417897 235444 at IFEA=EST

/DB XREF=gi:4261401 SEQ ID NO: 99 /DB XREF=estag55b06.x1 (DNA) /CLONE=IMAGE:2112659 /UG=Hs.235860 ESTs ESTs Consensus includes gb:AA827649 235515 at /FEA=EST

/DB XREF=gi:2900090 SEQ ID NO: 100 !DB_~~REF=est:odOla12.s1 (DNA) /CLONE=IMAGE:1357918 /UG=Hs.105317 ESTs ESTs Consensus includes gb:AI493909 235562 at /FEA=EST

/DB _X_RFF=gi:4394912 SEQ ID NO: 101 /DB XREF=est:qz94e02.x1 (DNA) /CLONE=IMAGE:2042234 /UG=Hs.6131 ESTs ESTs Consensus includes gb:AV741130 235651 at /FEA=EST

/DB XREF=gi:10858711 SEQ ID NO: 102 /DB XREF=est:AV741130 (DNA) /CLONE=CBCATB06 /UG=Hs.173704 ESTs, Moderately similar to ALU8_HUMAN

ALU SUBFAMILY SX SEQUENCE

CONTAMINATION WARNING ENTRY

H.sa iens ESTs, Weakly Consensus includes gb:AI864053 235678_at similar /FEA=EST

to I38588 reverselDB_XREF=gi:5528160 transcriptase /DB XREF=est:wj55h10.x1 homolog [H. sapiens] /CLONE=IMAGE:2406787 IUG=Hs.3 ESTs, Weakly similar to I38588 reverse SEQ ID NO: 103 transcriptase homolog H.sapiens (DNA) ESTs Consensus includes gb:AW339510 235866 at /FEA=EST /DB XREF=gi:6836136 SEQ ID NO: 104 /DB XREF=est:xz91h08.x1 (DNA) /CLONE=IMAGE:2871615 /UG=Hs.42722 ESTs ESTs Consensus includes gb:AI076192 236422 at /FEA=EST

/DB XREF=gi:3405370 SEQ ID NO: 105 /DB XREF=est:oz01g07.x1 (DNA) /CLONE=IMAGE:1674108 /UG=Hs.131933 ESTs ESTs Consensus includes gb:AL044570 236548 at /FEA=EST

/DB XREF=gi:5432785 SEQ ID NO: 106 /DB XREF=est:DKFZp434L082_sl (DNA) /CLONE=DI~FZp434L082 /LJG=Hs.147975 ESTs ESTs Consensus includes gb:AI968097 237835 at /FEA=EST

/DB XREF=gi:5764915 SEQ ID NO: 107 /DB XREF=est:wu13a12.x1 (DNA) /CLONE=IMAGE:2516830 /UG=Hs.131360 ESTs ESTs Consensus includes gb:AI733801 237923 at /FEA=EST

/DB XREF=gi:5054914 SEQ ID NO: 108 lDB_XREF=est:qk39c04.x5 (DNA) /CLONE=IMAGE:1871334 lUG=Hs.146186 ESTs ESTs Consensus includes gb:BF594323 238103 at /FEA=EST .

/DB XREF=gi:11686647 SEQ ID NO: 109 /DB XREF=est:7h79g07.x1 (DNA) /CLONE=IMAGE:3322236 /UG=Hs.158989 ESTs Homo Sapiens, Consensus includes gb:T69015 /FEA=EST238422 at clone MGC:16402 /DB XREF=gi:684163 IMAGE:3940360, /DB XREF=est:yc31~4.s1 mRNA, complete /CLONE=IMAGE:82303 /LJG=Hs.192728 cds ESTs SEQ ID NO: 110 (DNA) ESTs Consensus includes gb:AA502384 238956 at /FEA=EST

/DB_XKEF=gi:2237351 SEQ ID NO: 111 /DB XREF=est:ne27f1l.sl (DNA) /CLONE=IMAGE:898605 /UG=Hs.151529 ESTs ESTs Consensus includes gb:AI739241 238984 at /FEA=EST

/DB XREF=gi:5101222 SEQ ID NO: 112 /DB XREF=est:wi14h02.x1 (DNA) /CLONE=IMAGE:2390259 fUG=Hs.171480 ESTs ESTs Consensus includes gb:AA088446 239065 at /FEA=EST

/DB XRFF=gi:1633958 SEQ ID NO: 113 /DB_XREF=est:z189f04.s1 (DNA) /CLONE=IMAGE:511807 /UG=Hs.170298 ESTs ESTs Consensus includes gb:AI493046 239148 at /FEA=EST

/DB XRFF=gi:4394049 SEQ ID NO: 114 /DB XREF=est:qz49b04.x1 (DNA) /CLONE=IMAGE:2030191 /LTG=Hs.146133 ESTs ESTs Consensus includes gb:AI243098 239966 at /FEA=EST

/DB XREF=gi:3838495 SEQ ID NO: 115 /DB XREF=est:qh26e03.x1 (DNA) /CLONE=IMAGE:1845820 lUG=Hs.178398 ESTs ESTs, Weakly Consensus includes gb:AI633523 240106 at similar /FEA=EST

to A49175 Motch /DB XREF=gi:4684853 B

protein - mouse /DB XREF=estah68b1 l.xl [M.musculus] /CLONE=IMAGE:2123805 /LTG=Hs.44705 ESTs SEQ ID NO: 116 (DNA) ESTs Consensus includes gb:AI300126 240830 at /FEA=EST

/DB XREF=gi:3959472 SEQ ID NO: 117 /DB XREF=est:qn54f02.x1 (DNA) /CLONE=IMAGE:1902075 lUG=Hs.257858 ESTs ESTs Consensus includes gb:AI917390 240964 at /FEA=EST

/DB~XR.EF=gi: 563 7245 SEQ ID NO: 118 /DB XREF=estas79a05.x1 (DNA) /CLONE=IMAGE:2237456 /UG=Hs.99415 ESTs betacellulin Consensus includes gb:AI620677 241412iat /FEA=EST

/DB XREF=gi:4629803 SEQ ID NO: 119 /DB XREF=estau85e09.x1 (DNA) /CLONE=IMAGE:2257864 /UG=Hs.154191 ESTs ESTs Consensus includes gb:H05025 /FEA=EST241874 at /DB _X_RFF=gi:868577 SEQ ID NO: 120 /DB XREF=est:y174g12.s1 (DNA) /CLONE=IMAGE:43864 /UG=Hs.323767 ESTs ESTs Consensus includes gb:AW024656 242358 at /FEA=EST /DB XREF=gi:5878186 SEQ ID NO: 121 /DB XREF=est:wu78hO5.xl (DNA) /CLONE=IMAGE:2526201 /UG=Hs.233382 ESTs, Moderately similar to AF119917 PR02822 H.sa iens ESTs Consensus includes gb:BF696216 242626 at /FEA=EST

/DB XREF=gi:11981624 SEQ ID NO: 122 /DB XREF=est:602124536F1 (DNA) /CLONE=IMAGE:4281632 /UG=Hs.188724 ESTs ESTs Consensus includes gb:N57929 242978 x at /FEA=EST

/DB XRFF=gi:1201819 SEQ ID NO: 123 /DB XREF=est:yv61e06.s1 (DNA) /CLONE=IMAGE:247234 /UG=Hs.48100 ESTs ESTs, Weakly similarConsensus includes gb:AI457984 243729 /FEA=EST at to ALU1_HUMAN /DB XREF=gi:4312002 _ ALU SUBFAMILY /DB XREF=estaj66a04.x1 J

SEQUENCE /CLONE=IMAGE:2146446 !UG=Hs.165900 CONTAMINATION ESTs, Weakly similar to ALUC_HLJMAN

WARNING ENTRY ! ! ! ! ALU CLAS S C WARNING
ENTRY ! ! !

[H.sapiens] H.sapiens SEQ ID NO: 124 (DNA) ESTs Consensus includes gb:AA581439 244650 at lFEA=EST

/DB _X_RFF=gi:2359211 SEQ ID NO: 125 /DB XREF=est:nh13c10.s1 (DNA) /CLONE=IMAGE:952242 !UG=Hs.152328 ESTs Biological Validation of Biomarker Candidates: Modulation of Expression by Treatment with Ligands for EGFR or by Treatment with Inhibitors for EGFR
To validate the significance of the biomarker candidates to predict the activity of the EGFR pathway and thereby the sensitivity of cancer cell to inhibition of EGFR
by therapy, genes that would be regulated by the EGFR pathway were identified.
Demonstration of that property for the EGFR biomaxker candidates described above would add additional credibility as it would link these genes functionally to the EGFR
pathway. Colon cancer and a lung cancer cell lines were treated with epidermal growth factor, in the absence of serum or, in the presence of serum with the EGFR
modulator BMS-461453 or the EGFR modulator cetuximab (also known as C225, a chimeric monoclonal EGFR antibody). To identify genes induced by epidermal growth factor, serum starved cells were treated with 20ng/ml EGF for 0.5, 6, and 1 ~
hours. Control cells were treated with media alone. The expression profiling was performed, and data was analyzed using GeneChip~ Expression Analysis software MAS 5.0 (Affymetrix, Santa Clara, California).
Genes inhibited by EGFR antagonists were identified by treating cells in the presence of 10% serum with 0.5uM of BMS-461453 or lug/ml or 5ug/ml of C225 for 6 and 24 hours. Cells exposed to 0.05% DMSO were used as the experimental control. Expression profiling was performed, and data were analyzed using GeneChip~ Expression Analysis software MAS 5Ø
The gene expression of the inhibitor or EGFR treated cell lines was compared pair-wise to the untreated controls. Polynucleotides from the biomarker list, in which expression was increased two fold with EGFR exposure or decreased two fold with EGFR inhibitor treatment compared to the untreated controls, were considered to be modulated by EGFR. These biomarkers are provided in Table 4. Examples of the biomarkers include EphAl, B-cell translocation gene 2, prostaglandin-endoperoxide synthase 2 and serine (or cysteine) proteinase inhibitor (clade B), which are highly expressed in sensitive cells and up regulated by treatment with EGFR. On the other hand, spondin 1, talin 2 and nuclear receptor subfamily 3 are genes whose expression levels correlate with sensitivity or resistance of colon cancer cell lines and are consistently down regulated by treatment with EGFR inhibitors BMS-461453 and C225. It appears that these biomarkers are likely to be directly or indirectly involved in the EGFR signaling pathway, based on their expression modulation by EGF or EGFR inhibitor treatment.
Identification of Top Biomarkers In an attempt to further prioritize biomarkers for use in predicting response of cancer cells to treatment with one or more EGFR modulators, the following filter criteria were used on the Table 4 biomarkers to identify a total of fourteen biomaxkers (Table 5) as the top biomarkers:

(1) results from the highly significant correlation of gene expression with ICSO:
A p-value < 0.01 in the student TTEST or a Pearson value < - 0.6 described above;
(2) results from the modulation of expression by EGFR ligand and/or EGFR
inhibitor treatment described above; and (3) biomarkers supported by literature revealing a direct relationship between the EGFR pathway and the biomarkers.
TABLE 5 - Top Fourteen Biomarkers Biomarker Name Literature SupportInduced by EGFI

Citation Inhibited by EGFR antagonist mucin 2, J Biol Chem. 2002 Expression inhibited 2 fold Aug by EGFR

intestinal/tracheal30;277(35):32258-67antagonist in GEO colon cancer cell MLTC2) line intestinal mucinNo Expression inhibited 2 fold 3 by EGFR

(MLTC3) antagonist in GEO colon cancer cell line Homo Sapiens No Expression stimulated 2 cystic fold by fibrosis EGFR in H292 lung cancer cell line transmembrane conductance regulator ATP-binding cassette (sub-family C, member 7) (CFTR) f spondin ~ No Expression inhibited 2 fold by EGFR

(KIAA0762) protein antagonist in LOVO colon cancer cell line 3-hydroxy-3- J Invest Dermatol.Expression stimulated 3 2000 fold by methylglutaryl-Jan;l 14(1):83-7 EGFR in H292 lung cancer cell line Coenzyme A

synthase 2 serine (or cysteine)Electrophoresis. Expression stimulated 2 2001 fold by proteinase inhibitor,Aug;22(14):3001-8.EGFR in H292 lung cancer cell line Glade B

(ovalbumin), member 5 (SERPINBS

BTG family, No Expression stimulated 2 fold by member 2 (BTG2) EGFR in H292 lung cancer cell line talin 2 (TLN2) No Expression inhibited 2 fold by EGFR

antagonist in GEO colon cancer cell line arachidonic J Biol Chem. 1994 no acid Aug a oxygenase 26;269(34):21786-92.

prostaglandin 3 Biol Chem. 1994Expression stimulated 6 G/H Aug fold by synthase and 26;269(34):21786-92.EGFR in H292 lung cancer cell line cyclooxy enase EphAl (EPHA1) No Expression stimulated 2 fold by EGFR in CAC02 colon cancer cell line hemoglobin, alphaNo Expression inhibited 2 fold 1 by EGFR

(HBA1) antagonist in GEO colon cancer cell line bone morphogeneticDevelopment 2000 no rotein 2 Nov;127(22):4993-5005 betacellulin Biochem Biophys no (BTC)* Res Commun. 2002 Jun 28;294(5):1040-6 *The gene betacellulin showed counter regulation with EGFR expression as defined for the EGFR-A list but had just a p value of 0.04 in the Student's TTest for correlation with ICSO. It was still selected as a top biomarker for the strong literature support, as betacellulin is one of the published ligands of EGFR.
Utility of Biomarkers Polynucleotides that correlate to a specific property of a biological system can be used to make predictions about that biological system and other biological systems.
To show the predictive utility of biomarkers that correlate to EGFR modulator sensitivity and resistance, these polynucleotides were tested for their ability to predict the response of twenty two colon cancer cell lines to a small molecule EGFR
modulator.
The invention includes single biomarkers including, for example, the fourteen top biomarkers which were tested in a voting scheme. For that purpose, the mean expression value was calculated for all fourteen biomarkers. Colon cancer cell lines which showed an expression level above the mean were then voted to be sensitive, and colon cancer cell lines with expression levels below the mean were voted to be resistant. After this procedure, the voting was compared to the actual sensitivity/resistance status according to the definition based on ICSQ (see above) and an error rate was calculated. The error rates of the fourteen top biomarkers are shown in Table 6.
TABLE 6 - Error Rates of Fourteen Top Biomarkers ~ Biomarker Name ~ Pearsons value ~ TTEST P value ~ Prediction error rate mucin 2, -0.531 0.0083 20%

intestinal/tracheal (MUC2) intestinal mucin-0.639 0.0004 11.72%

(MUC3) Homo sapiens -0.646 9E-OS 5.9%
cystic fibrosis transmembrane conductance regulator ATP-binding cassette (sub-family C, member 7) (CFTR) f spondin -0.622 0.0004 12.8%
.

(KIAA0762) protein 3-hydroxy-3- -0.575 0.0029 21.75%

methylglutaryl-Coenzyme A

synthase 2 serine (or cysteine)-0.62 0.0028 21.75%

proteinase inhibitor, Glade B

(ovalbumin), member 5 (SERPINBS

BTG family, -0.544 0.0042 20.5%

member 2 (BTG2) talin 2 (TLN2) -0.874 3E-OS 8.8%

E hAl (EPHAl) -0.647 0.0021 22%

hemoglobin, -0.744 8E-OS 20%
alpha 1 (HBAl) bone morphogenetic-0.555 0.0091 31.8%

protein 2 betacellulin -0.536 0.047 43.5%
(BTC) The biomarkers talin, the Cystic fibrosis conductance regulator (CFTR), and mucin 3 were the best single biomarkers with error rates below 12%.
EXAMPLES

IC50 determination--in vitro cytotoxicity assay A small molecule EGFR inhibitor, erlotinib HCl (BMS-461453), was tested for cytoxicity in vitro against a panel of twenty-two human colon cancer cell lines available from the American Type Culture Collection. Cytotoxicity was assessed in cells by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carbaxymethoxyphenyl)-2-(4-sulphenyl)-2H-tetrazolium, inner salt) assay (T.L. Riss et al., 1992, Mol.
Biol. Cell, 3 (Suppl.):184a).
To carry out the assays, the colon cells were plated at 4,000 cell/well in 96 well microtiter plates and 24 hours later serial diluted drugs were added. The concentration range for the EGFR inhibitor was from 5 ~,g/ml to 0.0016 ~,g/ml (roughly 10 ~,M to 0.0032 qM). The cells were incubated at 37 °C for 72 hours at which time the tetrazolium dye MTS (333 ~.g/ml final concentration) in combination with the electron coupling agent phenazine methosulfate (25 ~M final concentration) was added. A dehydrogenase enzyme in live cells reduces the MTS to a form that absorbs light at 492 nm that can be quantified spectrophotometrically. The greater the absorbency, the greater the number of live cells. The results were expressed as an ICSQ, which is the drug concentration required to inlubit cell proliferation (i.e., absorbance at 450 nm) to 50% of that of untreated control cells. The mean ICSQ
and standard deviation (SD) from multiple tests for each cell line were calculated.
Resistant/sensitive classification The cell lines with ICSO below 6 ~M were defined as sensitive to the EGFR
inhibitor, whereas those with ICSO above 6 ~,M were considered to be resistant. The resistant/sensitive classification are shown above in Table 1, with five cell lines classified as sensitive and seventeen cell lines classified as resistant.
Gene expression profiling The colon cells were grown using standard cell culture conditions: RPMI
1640 supplemented to contain 10% fetal bovine serum, 100 IU/ml penicillin, 100 mg/ml streptomycin, 2 mM L-glutamine and 10 mM Hepes (all from GibcoBRL, Rockville, Maryland). RNA was isolated from 50-70% confluent cells or drug-treated cells using the RNeasyT"" kits commercially available from Qiagen (Valencia, California). Quality of the RNA was checked by measuring the 28s:18s ribosomal RNA ratio using Agilent 2100 bioanalyzer (Agilent, Technologies, Rockville, Maryland). Concentration of total RNA was determined spectrophotometrically.

~,g of total RNA from each cell line was used to prepare biotinylated probe according to the Af~'ymetrix Genechip~ Expression Analysis Technical Manual, 2001.
Targets were hybridized to AfFymetrix high density oligonucleotide array human HG-U133 set chips (Affymetrix, Santa Clara, California). Arrays were then washed, and stained using the GeneChip Fluidics station according to the manufacture's instructions. The HG-U133 set consisting of two GeneChip~ arrays contains nearly 45,000 probe sets representing more than 39,000 transcripts derived from approximately 33,000 well-substantiated human genes.
Preprocessing of microarray data for selecting biomarkers Scanned image files were visually inspected for artifacts and analyzed with GeneGhip~ Expression Analysis software MAS 5.0 (Affymetrix, Santa Clara, California). The "Detection Call" (see Affymetrix manual) was used to determine whether a transcript was detected within one sample, as well as the "Signal"
(see Affymetrix Genechip° Expression Analysis Technical Manual, 2001) which measured the relative abundance of a transcript. The trimmed mean intensity for each chip was scaled to 1,500 (see Affymetrix manual) in order to account for any minor difFerences in global chip intensity, so that the overall expression level for each cell line is comparable. Affymetrix control sequences were removed prior to analysis.
Induction Studies of colon and breast cell lines with EGFR inhibitors or EGFR
ligand and selection of genes modulated by the inductions The five colon cell lines and one lung cell line indicated with asterisks in Table 1 were used in the drug induction study. Three of the colon cell lines express EGFR and are sensitive to the EGFR inhibitor BMS-461453. The SW480 cell line, while expressing EGFR, is insensitive to the EGFR inhibitor, and the COL0320 DM
does not express EGFR and is EGFR inhibitor resistant. The lung cancer cell line H292 expresses EGFR, but its sensitivity status is unknown. Cells were seeded in a 10 cm2 culture plate with the medium described above and cultured for 24 hours.
For the EGF induction studies, the colon cell line CAC02 and the lung cancer H292 cell line were washed 2X PBS, and the media was changed to RPMI without serum. The next day the cells were treated with 20 ng/ml EGF, and eventually lysed -71 _ i for RNA isolation 0.5, 6 and 18 hours post treatment. Gene expression was profiled as described below.
EGFR inhibition studies were conducted on the colon cell lines GEO, CCD33-CO, SW480 and COL0320DM. The expression profiling was performed as described above and data was analyzed using GeneChip~ Expression Analysis software MAS 5Ø The expression data of EGFR inhibitor treated cell lines were compared pair-wise to that of untreated same cell line. A change was considered significant if a two fold difference in expression was demonstrated between the treated and the untreated control. Analysis was done for all four cell lines to compare the gene expression with or without EGFR inhibitor treatment.

RNA quantification was performed using the SYBR Green real-time PCR.
The SYBR Green real-time PCR assay is one of the most precise methods for assaying the concentration of nucleic acid templates.
RNA can be prepared using standard methods, preferably, employing the RNeasy Kit commercially available from Qiagen (Valencia, California). cDNA
template for real-time PCR can be generated using the SuperscriptTM Fixst Strand Synthesis system for RT-PCR. SYBR Green real-time PCR reactions are prepared as follows: the reaction mix contains 20 ng first strand cDNA; 50 nM Forward Primer;
50 nM Reverse Primer; 0.75X SYBR Green I (Sigma); 1X SYBR Green PCR Buffer (SOmMTris-HCl pH 8.3, 75 mM KCl); 10% DMSO; 3 mM MgCl2; 300 ~M each dATP, dGTP, dTTP, dCTP; 1 U Platinum~ Taq DNA Polymerase High Fidelity (Cat# 11304-029; Life Technologies; Rockville, Maryland). Real-time PCR is performed using an Applied Biosystems 5700 Sequence Detection System.
Conditions are 95 °C for 10 minutes (denaturation and activation of Platinum~ Taq DNA Polymerase), 40 cycles of PCR (95 °C for 15 seconds, 60 °C
for 1 minute).
PCR products are analyzed for uniform melting using an analysis algorithm built into the 5700 Sequence Detection System.
cDNA quantification used in the normalization of template quantity is performed using SYBR Green real-time PCR. Expression of EGFR is normalized to GAPDH expression as described below.
_72_ The sequences for the GAPDH oligonucleotides used in the SYBR Green real-time PCR reactions are:
GAPDH-F: 5'-AGCCGAGCCACATCGCT-3' (SEQ ID NO: 191) GAPDH-R: 5'-GTGACCAGGCGCCCAATAC-3' (SEQ ID NO: 192) The sequences for the EGFR oligonucleotides used in the SYBR Green real-time PCR reactions axe:
EGFR-F: 5'- GCGTCTCTTGCCGGAATGT-3' (SEQ ID NO: 193) EGFR-R: 5'- AGCCGAGGCAGGGAATGCGTG-3' (SEQ ID NO: 194) The Sequence Detection System generates a Ct (threshold cycle) value that is used to calculate a concentration for each input cDNA template. cDNA levels for each gene of interest are normalized to GAPDH cDNA levels to compensate for variations in total cDNA quantity in the input sample. This is done by generating GAPDH Ct values for each cell line. Ct values for the gene of interest and GAPDH
are inserted into a modified version of the ~BCt equation (Applied Biosystems Prism~ 5700 Sequence Detection System User Manual) which is used to calculate a GAPDH normalized relative cDNA level for each specific cDNA. The ~BCt equation is: relative quantity of nucleic acid template =2ssct = 2~scta-sctb~~ where BCta = Ct target - Ct GAPDH, and BCtb = Ct reference - Ct GAPDH.
EXAMPLE 3 - PRODUCTION OF ANTIBODIES AGAINST THE BIOMARI~ERS
Antibodies against the biomarkers can be prepared by a variety of methods.
For example, cells expressing an biomarker polypeptide can be administered to an animal to induce the production of sera containing polyclonal antibodies directed to the expressed polypeptides. In one aspect, the biomarker protein is prepared and isolated or otherwise purified to render it substantially free of natural contaminants, using teclniiques commonly practiced in the art. Such a preparation is then introduced into an animal in order to produce polyclonal antisera of greater specific activity for the expressed and isolated polypeptide.
In one aspect, the antibodies of the invention are monoclonal antibodies (or protein binding fragments thereof). Cells expressing the biomarker polypeptide can be cultured in any suitable tissue culture medium, however, it is preferable to culture cells in Earle's modified Eagle's medium supplemented to contain 10% fetal bovine serum (inactivated at about 56 °C), and supplemented to contain about 10 g/1 nonessential amino acids, about 1,00 U/ml penicillin, and about 100 p,g/ml streptomycin.
The splenocytes of immunized (and boosted) mice can be extracted and fused with a suitable myeloma cell line. Any suitable myeloma cell line can be employed in accordance with the invention, however, it is preferable to employ the parent myeloma cell line (SP2/0), available from the ATCC. After fusion, the resulting hybridoma cells are selectively maintained in HAT medium, and then cloned by limiting dilution as described by Wands et al. (1981, Gastr-oenterology, 80:225-232).
The hybridoma cells obtained through such a selection are then assayed to identify those cell clones that secrete antibodies capable of binding to the polypeptide immunogen, or a portion thereof.
Alternatively, additional antibodies capable of binding to the biomarker polypeptide can be produced in a two-step procedure using anti-idiotypic antibodies.
Such a method makes use of the fact that antibodies are themselves antigens and, therefore, it is possible to obtain an antibody that binds to a second antibody. In accordance with this method, protein specific antibodies can' be used to immunize an animal, preferably a mouse. The splenocytes of such an immunized animal are then used to produce hybridoma cells, and the hybridoma cells are screened to identify clones that produce an antibody whose ability to bind to the protein-specific antibody can be blocked by the polypeptide. Such antibodies comprise anti-idiotypic antibodies to the protein-specific antibody and can be used to immunize an animal to induce the formation of further protein-specific antibodies.

The following immunofluorescence protocol may be used, for example, to verify EGFR biomarker protein expression on cells or, for example, to check for the presence of one or more antibodies that bind EGFR biomarkers expressed on the surface of cells. Briefly, Lab-Tek II chamber slides are coated overnight at 4 °C with 10 micrograms/milliliter (p.g/ml) of bovine collagen Type II in DPBS
containing calcium and magnesium (DPBS++). The slides are then washed twice with cold DPBS++ and seeded with 8000 CHO-CCRS or CHO pC4 transfected cells in a total volume of 125 p,l and incubated at 37 °C in the presence of 95% oxygen / 5% carbon dioxide.
The culture medium is gently removed by aspiration and the adherent cells are washed twice with DPBS++ at ambient temperature. The slides are blocked with DPBS++ containing 0.2% BSA (blocker) at 0-4 °C for one hour. The blocking solution is gently removed by aspiration, and 125 p,l of antibody containing solution (an antibody containing solution may be, for example, a hybridoma culture supernatant which is usually used undiluted, or serum/plasma which is usually diluted, e.g., a dilution of about 1/100 dilution). The slides are incubated for 1 hour at 0-4 °C. Antibody solutions are then gently removed by aspiration and the cells are washed five times with 400 ~l of ice cold blocking solution. Next, 125 ~1 of 1 ~g/ml rhodamine labeled secondary antibody (e.g., anti-human IgG) in blocker solution is added to the cells. Again, cells are incubated for 1 hour at 0-4 °C.
The secondary antibody solution is then gently removed by aspiration and the cells are washed three times with 400 p,l of ice cold blocking solution, and five times with cold DPBS++, The cells are then fixed with 125 p,l of 3.7% formaldehyde in DPBS++ for 15 minutes at ambient temperature. Thereafter, the cells are washed five times with 400 pl of DPBS++ at ambient temperature. Finally, the cells are mounted in 50% aqueous glycerol and viewed in a fluorescence microscope using rhodamine filters.

SEQUENCE LISTING
<l10> Amler, Lukas C.
Januario, Thomas <120> BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO EPIDERMAL
GROWTH FACTOR RECEPTOR MODULATORS
<130> D0304 PCT
<150> US 60/438,735 <151> 2003-01-08 <160> 194 <170> PatentIn version 3.2 <210> 1 <211> 2058 <2l2> DNA
<213> Human ' <400> 1 cggtttctgc tgggtttctg aactgctggg tttctgcttg ctcctctgga gatgcagcgt 60 ctgttgactc cagtgaagcg cattctgcaa ctgacaagag cggtgcagga aacctccctc 120 acacctgctc gcctgctccc agtagcccac caaaggtttt ctacagcctc tgctgtcccc 180 ctggccaaaa cagatacttg gccaaaggac gtgggcatcc tggccctgga ggtctacttc 240 ccagcccaatatgtggaccaaactgacctggagaagtataacaatgtggaagcaggaaag300 tatacagtgggcttgggccagacccgtatgggcttctgctcagtccaagaggacatcaac360 tccctgtgcctgacggtggtgcaacggctgatggagcgcatacagctcccatgggactct420 gtgggcaggctggaagtaggcactgagaccatcattgacaagtccaaagctgtcaaaaca480 gtgctcatggaactcttccaggattcaggcaatactgatattgagggcatagataccacc540 aatgcctgctacggtggtactgcctccctcttcaatgctgccaactggatggagtccagt600 tcctgggatggtcgttatgccatggtggtctgtggagacattgccgtctatcccagtggt660 aatgctcgtcccacaggtggggccggagctgtggctatgctgattggcccaaaggcccct720 ctggccctggagcgagggctgaggggaacccatatggagaatgtgtatgacttctacaaa780 ccaaatttggcctcggagtacccaatagtggatgggaagctttccatccagtgctacttg840 cgggccttggatcgatgttacacatcataccgtaaaaaaatccagaatcagtggaagcaa900 gctggcagcgatcgacccttcacccttgacgatttacagtatatgatctttcatacaccc960 ttttgcaagatggtccagaagtctctggctcgcctgatgttcaatgacttcctgtcagcc1020 agcagtgaca cacaaaccag cttatataag gggctggagg ctttcggggg gctaaagctg 1080 gaagacacct acaccaacaa ggacctggat aaagcacttc taaaggcctc tcaggacatg 1140 ttcgacaaga aaaccaaggc ttccctttac ctctccactc acaatgggaa catgtacacc 1200 tcatccctgtacgggtgcctggcctcgcttctgtcccaccactctgcccaagaactggct1260 ggctccaggattggtgccttctcttatggctctggtttagcagcaagtttcttttcattt1320 cgagtatcccaggatgctgctccaggctctcccctggacaagttggtgtccagcacatca1380 gacctgccaaaacgcctagcctcccgaaagtgtgtgtctcctgaggagttcacagaaata1440 atgaaccaaagagagcaattctaccataaggtgaatttctccccacctggtgacacaaac1500 agccttttcccaggtacttggtacctggagcgagtggacgagcagcatcgccgaaagtat1560 gcccggcgtcccgtctaaaggtgttctgcagatccatggaaagcttcctgggaaacgtat1620 gctagcagagcttctccccgtgaatcatatttttaagatcccactcttagctggtaaatg1680 aatttgaatcgacatagtagccccataagcatcagccctgtagagtgaggagccatctct1740 agcgggcccttcattcctctccatgctgcaatcactgtcctgggcttatggtgcctatgg1800 actaggggtcctttgtgaaagagcaagatggagcaatggagagaagacctcttcctgaat1860 cactggactccagaaatgtgcatgcagatcagctgttgccttcaagatccagataaactt1920 tcctgtcatgtgttagaactttattattattaatattgttaaacttctgtgctgttcctg1980 tgaatctccaaattttgtaccttgttctaagctaatatatagcaattaaaaagagagaaa2040 gagaaaaaaa aaaaaaaa 2058 <210> 2 <211> 532 <212> DMA
<213> Human <220>
<221> misc_feature <222> (519)..(519) <223> n is a, c, g, or t <400> 2 taactatggaaaaccatgtttatttttaataaaggatgacatttccaatcagtaaaatat60 cataaaagtataaaaatgtactaagtacaatcattagcattatgttataggggaatagtg120 gttataacttttccctgtaagatggcacattggatggtcacagttggcttgatttacaga180 ggggcaagagtaggtgaccagttgtaccagttgctccagtttcctaggatttgggactct240 tgtaaaatgagaaagtcccaggcaaactgggacggttggtcctacaagaaaaagagcagc300 atcagagtgttggctatagtttggaacttaggaacaggatcagacattattttttaactt360 ctccacctat tttcccttta gctgtgaaat aaaaatccct tttgttatta ctgagggtgt 420 tacagctttc agaggctttt ttaccactgg gtttcatgta attttgactt aatacctatg 480 tcaagcctgg gaagaaaggc agttctaatc aacttgcang tgtggcattc tg 532 <210>

<211>

<212>
DNA

<213> n Huma <400>

ggggacttcttgaacttgcagggagaataacttgcgcaccccactttgcgccggtgcctt 60 tgccccagcggagcctgcttcgccatctccgagccccaccgcccctccactcctcggcct 120 tgcccgacactgagacgctgttcccagcgtgaaaagagagactgcgcggccggcacccgg 180 gagaaggaggaggcaaagaaaaggaacggacattcggtccttgcgccaggtcctttgacc 240 agagtttttccatgtggacgctctttcaatggacgtgtccccgcgtgcttcttagacgga 300 ctgcggtctcctaaaggtcgaccatggtggccgggacccgctgtcttctagcgttgctgc 360 ttccccaggtcctcctgggcggcgcggctggcctcgttccggagctgggccgcaggaagt 420 tcgcggcggcgtcgtcgggccgcccctcatcccagccctctgacgaggtcctgagcgagt 480 tcgagttgcggctgctcagcatgttcggcctgaaacagagacccacccccagcagggacg 540 ccgtggtgcccccctacatgctagacctgtatcgcaggcactcaggtcagccgggctcac 600 ccgccccagaccaccggttggagagggcagccagccgagccaacactgtgcgcagcttcc 660 accatgaagaatctttggaagaactaccagaaacgagtgggaaaacaacccggagattct 720 tctttaatttaagttctatccccacggaggagtttatcacctcagcagagcttcaggttt 780 tccgagaacagatgcaagatgctttaggaaacaatagcagtttccatcaccgaattaata 840 tttatgaaatcataaaacctgcaacagccaactcgaaattccccgtgaccagacttttgg 900 acaccaggttggtgaatcagaatgcaagcaggtgggaaagttttgatgtcacccccgctg 960 tgatgcggtggactgcacagggacacgccaaccatggattcgtggtggaagtggcccact 1020 tggaggagaaacaaggtgtctccaagagacatgttaggataagcaggtctttgcaccaag 1080 atgaacacagctggtcacagataaggccattgctagtaacttttggccatgatggaaaag 1140 ggcatcctctccacaaaagagaaaaacgtcaagccaaacacaaacagcggaaacgcctta 1200 agtccagctgtaagagacaccctttgtacgtggacttcagtgacgtggggtggaatgact 1260 ggattgtggctcccccggggtatcacgccttttactgccacggagaatgcccttttcctc 1320 tggctgatcatctgaactccactaatcatgccattgttcagacgttggtcaactctgtta 1380 actctaagat tcctaaggca tgctgtgtcc cgacagaact cagtgctatc tcgatgctgt 1440 accttgacga gaatgaaaag gttgtattaa agaactatca ggacatggtt gtggagggtt 1500 gtgggtgtcg ctagtacagc aaaattaaat acataaatat atatata 1547 <210> 4 <211> 5019 <212> DNA
<213> Human <400> 4 gcctccgctg cagtcgctgc gtctccaagc aacatggctg acaaggccaa gcctgccaaa 60 gctgccaaca ggacgccccc caagtccccg ggggacccct cgaaggaccg ggcagccaag 120 aggctgtcgc tggaatcgga gggtgctggt gagggggcag ccgcatcccc tgagctcagt 180 gccctggaggaggccttccggcgctttgccgtgcacggggacgccagggccaccgggagg240 gagatgcacggcaagaactggtcgaagctgtgcaaggactgccaggtgatcgacggcagg300 aacgtgaccgtcactgacgtggacatcgtcttcagcaagatcaaagggaagtcttgccgg360 accatcacctttgagcagttccaggaggcgctggaggagctcgccaagaagcgattcaaa420 gacaagagcagcgaggaggccgttcgcgaggtgcacaggctcatcgagggcaaggcgccc480 atcatctcaggggtgacgaaagccatctcgtcgcccacagtgtcgaggctcacggacacc540 accaagttcacgggctcccacaaggagcgcttcgacccctctggcaagggcaagggcaag600 gctggccgcgtggatctggtggacgagtcaggctatgtgtccggctacaagcacgcaggc660 acctacgaccagaaggtgcaagggggcaagtagcccccgctccatgcctcgcggcactgc720 cggtgtccccagagcagggactctgtcacctcgcacttcattacattcctgtactaactg780 gggcagaactcagacgggtgccccagagggggctggggggcggccaggcccaggcctccc840 tcctgcccctcctcctaccggatgcccccagcactcccctctcaaaccaggtttgggccc900 cagttcgctgaccctcctaatacacctgcctcgtcctcagccatttccaaagtgtctcgc960 ggatcacaccacactgggcacgtggtttgcaggtcaaaggggcgttttaaagcagctggc1020 tgtcatggcaacaggaggctgtgctgacctcctgagcggcagacaccttccaggagccct1080 gagggtggcaggagctaaccccaaccagcaggcaactaacacggaattggccccacaccg1140 gacgtgggaggtgtctgtggggcccgaggcctgtcctgtgtgcagcggacaccacggggc1200 cttcctgctttcctgggcagagggcagagtgaggccacctggcgggggtgctgggcgcct1260 ggcacatgtgtggggaagccggtcacatggacacacctgtgcacacatgcctacaggcca1320 gctctgtgccaagggcaacctaggtaaaacgaaagccgtcaggggcagtgggcggcttcc1380 cggctgaccacagtggcttggactgtgagggtagagtaggctcgctttgctttcctgaga1440 agatgcggtggctgcctatgttctcagagcgggtctgggaagattcagaatgtccggtcc1500 ctgtggtgttgccaggcaagagacacgaagtgccgagacactcctcgcctcaccgcgtga1560 cagagcctctgcccggccctcccgttcgcccgtcctcactagctgcaccctgtttgctcg1620 cagacctcccattgccacagcccaagcaccttcttcaactctcccaaaatggctcagcct1680 aacctctcctggccaatcccccccgccggagagcaggacactagggaggacccccagtcc1740 tgcagtgtctgtgggggtttctctgccagcagggggctgagcagagcccatccaggacac1800 tccacactgccaggacacacccaggcggcccgcccttgcctgtctgcacctggggagaag1860 ccggcgctcctgctccctcctggggaggctgacgggtgtggccacccgctgtcacaatgg1920 cacactgccactgtcccttggcacgcacacagccacagccacacgtgtgacctgctgggc1980 cgtggttctggagtctacctgcggatgagcctgcggcagtcctggggaaacttttccaga2040 gcctgttagc'ccgtggctacggtcaggctctggccagggcagagggctgcccagggccag2100 gctcacagtacaggagggtggcgaggcccctccctcactggcacgcatgagcaccacccg2160 cctccccgactcccaagagtgcacctgctgcggccacagctccgtggaaggactccccct2220 acctgagcagagcagaagccccagggcggagctcccagccagcatggtccgctgagggct2280 ggggggcggtctccgaggcccctcaacagagaagcctccacctgaggatggggaggacct2340 ggcaggcagcttccacggcagggctgggaagttcagtgcctggaaataaagagcaaggaa2400 aaatggacctcaggcttcgtggctcctttaggatgtcacctcaccggcctggggaaggcg2460 gggggtgcccaagcccagccctgtgcccccgctgaacctggctggaccgcgtgtgaaagg2520 cagaactaacgtgcggaaacatttgaaaacaactctgaatgtgcggttcggaatcacccg2580 atcacagacgagcggtcaccggaatcgcccggtcacagacgagcagtcatcggactcacc2640 cgatcacagacgagcggtcaccggaatcgcccgatcacagacgagcggccaccggaatcg2700 cccaatcacagacaagcagtcatcggaatcacccgatcacagacgagcagtcatcggact2760 cacccgatcacagacgagcggtcaccagactcgcccgatcacagacgagcagtcatcgga2820 atcacccgatcacagacgagcagtcatcggactcacccgatcacagacgagcggtcacca2880 gaatcgcccgatcacagacgagcagtcatcggaatcacccgatcacagacgagtggccac2940 cggaatcacccgataacagcccatcacaactccaaagcccttgtgttgaaaaggccgagg3000 acgagtggtcaccaaacagggtggctccccaggtcccgaagcctgagacccggaaggccc3060 tggcacccttacaccctcggactcctgccctcctcggcctccctggccccagcgcggctc3120 caccctgggctgcgtctcctggtcacaggctgcgtttctcctttctgtccgtgggcagcc3180 cagtccccac agtcacggcc aagccacgca gaacgaacat gactccagag gacctcgccc 3240 tggagctgag cctggcgccg ggtcaggacg gagggaaggg cgggttgggg tccgcgggtc 3300 ctcacaccgc acggcaggca cagaggctcg ccaggccctg atccggtctg tggggacgag 3360 ggacactgag gagaggtgct gggcaccagg acgctgcctc ctggtccctg gttggcctca 3420 gacaagcacg gcctcgagaa aagagccaag cgcatcggga gcacaccaga aaccggccct 3480 gagcacgaga agagcctccg cccggcccgg gcaccacccg acctcgcagg gagcaggccc 3540 tgtcaccgac gggtcacctc gcccacacgg ccagcaccga ctcaccacag cccttcccag 3600 acctggctgg agtggccgga gcggcggggc tcatggctcc catcttggcc cctggaggtg 3660 agctcattca cagaagtggt cccttcactc tgagagagaa aatcgtggcg tgcatcccaa 3720 accctaggcc acgcctgtgg gtttcgtgaa tgagatcgag gctgctgtgg caccctgccc 3780 gtcctggcct ggagcaccct gggatcctgg agggagaggc cccacgcccc cactctccct 3840 ccacacttcc agggttggtg cccacgagtt agaggcacgg cctcccccag cggccctcag 3900 gcttttctca gacatgcggg agccaggaga gcacccttct ccactcagct ccaaagcgaa 3960 tctttgaaaa cacccactcg gctcccatct ctgtcaccta gccaggaggg gtagcaaaaa 4020 taaagtcacg aggacatagt ggtcaccact gtcagttaca acttgtctgt ggaatccgta 4080 attgcatctg tgtgccgcct ccgaacacag aacattgttt ggacggcagc cccactgcac 4140 ataacagacc cgtgcatctt cctcagtcag tttctgaata ttgtgaattc aggcaggtgt 4200 gtgttctctt ctgcatgttt ttatgcactg ccaattagct tctactaacc acggttcaac 4260 agaaaataaa tgtgtatttg tgaataacaa actgcacaac ctgcaaacca ggagagaggg 4320 acaggttctg tcaggggtga caccaggaca cagggacagg ttctgtcggg ggtgacacca 4380 ggacacaggg acaggttctg tcatgggtga cacgaggaca cagggacagg ttctatcatg 4440 ggtgacacca ggagagaggg acaggttctg ttgggggtga caagaggaga cagggacagg 4500 ttctgtcggg ggtgacacca ggagagaggg acaggttctg tcaggggtga caccaggaga 4560 gagggacagg ttctgttggg ggtgacacca ggacacagga ataggttctg tcgggaggac 4620 agtgctgatc gtgtctcagc atcaggaaag gagaaaggca gagggagagc gctgagaaga 4680 ctgttcacgc cagagtgctt atttattttt aatttactgc tataggataa gcaaccaggt 4740 agtgttccta acaattagcg ttaccaaaat taaagttcaa attatatgtt taaaatattg 4800 tagaagatat atatttatac tggactactt ttacaccttc taatatcctg tccaagtttg 4860 ggcgcagatg gtggagttgg gctggcatca tgtcctgtgg ccgccccact tgcctgttgg 4920 tgccactcca tcccgggccc cagggatgcc agctcagggc tgaccacagc agccctgcgt 4980 gggcatcacc tcctacccca gcccccatcc tgggctgct 5019 <210> 5 <211> 1155 <212> DNA
<213> Human <400>

atggattgcagtaacggatcggcagagtgtaccggagaaggaggatcaaaagaggtggtg60 gggacttttaaggctaaagacctaatagtcacaccagctaccattttaaaggaaaaacca120 gaccccaataatctggtttttggaactgtgttcacggatcatatgctgacggtggagtgg180 tcctcagagtttggatgggagaaacctcatatcaagcctcttcagaacctgtcattgcac240 cctggctcatcagctttgcactatgcagtggaattatttgaaggattgaaggcatttcga300 ggagtagataataaaattcgactgtttcagccaaacctcaacatggatagaatgtatcgc360 tctgctgtgagggcaactctgccggtatttgacaaagaagagctcttagagtgtattcaa420 cagcttgtgaaattggatcaagaatgggtcccatattcaacatctgctagtctgtatatt480 cgtcctgcattcattggaactgagccttctcttggagtcaagaagcctaccaaagccctg540 ctctttgtactcttgagcccagtgggaccttatttttcaagtggaacctttaatccagtg600 tccctgtgggccaatcccaagtatgtaagagcctggaaaggtggaactggggactgcaag660 atgggagggaattacggctcatctctttttgcccaatgtgaagacgtagataatgggtgt720 cagcaggtcctgtggctctatggcagagaccatcagatcactgaagtgggaactatgaat780 ctttttctttactggataaatgaagatggagaagaagaactggcaactcctccactagat840 ggcatcattcttccaggagtgacaaggcggtgcattctggacctggcacatcagtggggt900 gaatttaaggtgtcagagagatacctcaccatggatgacttgacaacagccctggagggg960 aacagagtgagagagatgtttagctctggtacagcctgtgttgtttgcccagtttctgat1020 atactgtacaaaggcgagacaatacacattccaactatggagaatggtcctaagctggca1080 agccgcatct tgagcaaatt aactgatatc cagtatggaa gagaagagag cgactggaca 1140 attgtgctat cctga 1155 <210> 6 <211> 2717 <212> DNA
<213> Human <400> 6 cagggtaacg ctgtcttgtg gacccgcact tcccacccga gacctctcac tgagcccgag .60 ccgcgcgcgacatgagccacgggaagggaaccgacatgctcccggagatcgccgccgccg120 tgggcttcctctccagcctcctgaggacccggggctgcgtgagcgagcagaggcttaagg180 tcttcagcggggcgctccaggaggcactcacagagcactacaaacaccactggtttcccg240 aaaagccgtccaagggctccggctaccgctgcattcgcatcaaccacaagatggacccca300 tcatcagcagggtggccagccagatcggactcagccagccccagctgcaccagctgctgc360 ccagcgagctgaccctgtgggtggacccctatgaggtgtcctaccgcattggggaggacg420 gctccatctgcgtcttgtacgaggaggccccactggccgcctcctgtgggctcctcacct480 gcaagaaccaagtgctgctgggccggagcagcccctccaagaactacgtgatggcagtct540 ccagctaggcccttccgcccccgccctgggcgccgccgtgctcatgctgccgtgacaaca600 ggccaccacatacctcaacctggggaactgtatttttaaatgaagagctatttatatata660 ttatttttttttaagaaaggaggaaaagaaaccaaaagttttttttaagaaaaaaaatcc720 ttcaagggagctgcttggaagtggcctccccaggtgcctttggagagaactgttgcgtgc780 ttgagtctgtgagccagtgtctgcctataggagggggagctgttagggggtagacctagc840 caaggagaagtgggagacgtttggctagcaccccaggaagatgtgagagggagcaagcaa900 ggttagcaactgtgaacagagaggtcgggatttgccctgggggaggaagagaggccaagt960 tcagagctctctgtctcccccagccagacacctgcatccctggctcctctattactcagg1020 ggcattcatgcctggacttaaacaatactatgttatcttttcttttatttttctaatgag1080 gtcctgggcagagagtgaaaaggcctctcctgattcctactgtcctaagctgcttttctt1140 gaaatcatgacttgtttctaattctaccctcaggggcctgtagatgttgctttccagcca1200 ggaatctaaagctttgggttttctgagggggggaggagggaactggaggttattggggtt1260 aggatggaagggaactctgcacaaaacctttgctttgctagtgctgctttgtgtgtatgt1320 gtggcaaataatttgggggtgatttgcaatgaaattttgggacccaaagagtatccactg1380 gggatgttttttggccaaaactcttccttttggaaccacatgaaagtcttgatgctgctg1440 ccatgatccctttgagaggtggctcaaaagctacagggaactccaggtcctttattactg1500 ccttcttttcaaaagcacaactctcctctaaccctcccctcccccttcccttctggtcgg1560 gtcatagagctaccgtattttctaggacaagagttctcagtcactgtgcaatatgccccc1620 tgggtcccaggagggtctggaggaaaactggctatcagaacctcctgatgccctggtggg1680 cttagggaaccatctctcctgctctccttgggatgatggctggctagtcagccttgcatg1740 tattccttggctgaatgggagagtgccccatgttctgcaagactacttggtattcttgta1800 gggccgacac taaataaaag ccaaaccttg ggcactgttt tttctccctg gtgctcagag 1860 cacctgtggg aaaggttgct gtctgtctca gtacaatcca aatttgtcgt agacttgtgc 1920 aatatatact gttgtgggtt ggagaaaagt ggaaagctac actgggaaga aactcccttc 1980 cttcaatttc tcagtgacat tgatgagggg tcctcaaaag acctcgagtt tcccaaaccg 2040 aatcaccttaagaaggacagggctagggcatttggccaggatggccaccctcctgctgtt2100 gccccttagtgaggaatcttcaccccacttcctctacccccaggttctcctccccacagc2160 cagtcccctttcctggatttctaaactgctcaattttgactcaaaggtgctatttaccaa2220 acactctccctacccattcctgccagctctgcctccttttcaactctccacattttgtat2280 tgccttcccagacctgcttccagtctttattgctttaaagttcactttgggcccacagac2340 ccaagagctaattttctggtttgtgggttgaaacaaagctgtgaatcactgcaggctgtg2400 ttcttgcatcttgtctgcaaacaggtccctgcctttttagaagcagcctcatggtctcat2460 gcttaatcttgtctctcttctcttctttatgatgttcactttaaaaacaacaaaacccct2520 gagctggactgttgagcaggcctgtctctcctattaagtaaaaataaatagtagtagtat2580 gtttgtaagctattctgacagaaaagacaaaggttactaattgtatgatagtgtttttat2640 atggaagaatgtacagcttatggacaaatgtacacctttttgttactttaataaaaatgt2700 agtaggataaaaaaaaa 2717 <210> 7 <211> 2249 <212> DNA
<2l3> Human <400>

ctcctctacaaagaggtggacagagaagacagcagagaccatgggacccccctcagcccc 60 tccctgcagattgcatgtcccctggaaggaggtcctgctcacagcctcacttctaacctt 120 ctggaacccacccaccactgccaagctcactattgaatccacgccattcaatgtcgcaga 180 ggggaaggaggttcttctactcgcccacaacctgccccagaatcgtattggttacagctg 240 gtacaaaggcgaaagagtggatggcaacagtctaattgtaggatatgtaataggaactca 300 acaagctaccccagggcccgcatacagtggtcgagagacaatataccccaatgcatccct 360 gctgatccagaacgtcacccagaatgacacaggattctataccctacaagtcataaagtc 420 agatcttgtgaatgaagaagcaaccggacagttccatgtatacccggagctgcccaagcc 480 ctccatctccagcaacaactccaaccccgtggaggacaaggatgctgtggccttcacctg 540 tgaacctgaggttcagaacacaacctacctgtggtgggtaaatggtcagagcctcccggt 600 cagtcccaggctgcagctgtccaatggcaacatgaccctcactctactcagcgtcaaaag660 gaacgatgcaggat'cctatgaatgtgaaatacagaacccagcgagtgccaaccgcagtga720 cccagtcaccctgaatgtcctctatggcccagatgtccccaccatttccccctcaaaggc780 caattaccgtccaggggaaaatctgaacctctcctgccacgcagcctctaacccacctgc840 acagtactcttggtttatcaatgggacgttccagcaatccacacaagagctctttatccc900 caacatcactgtgaataatagcggatcctatatgtgccaagcccataactcagccactgg960 cctcaataggaccacagtcacgatgatcacagtctctggaagtgctcctgtcctctcagc1020 tgtggccaccgtcggcatcacgattggagtgctggccagggtggctctgatatagcagcc1080 ctggtgtattttcgatatttcaggaagactggcagattggaccagaccctgaattcttct1140 agctcctccaatcccattttatcccatggaaccactaaaaacaaggtctgctctgctcct1200 gaagccctatatgctggagatggacaactcaatgaaaatttaaagggaaaaccctcaggc1260 ctgaggtgtgtgccactcag,agacttcacctaactagagacagtcaaactgcaaaccatg1320 gtgagaaattgacgacttcacactatggacagcttttcccaagatgtcaaaacaagactc1380 ctcatcatgataaggctcttacccccttttaatttgtccttgcttatgcctgcctctttc1440 gcttggcaggatgatgctgtcattagtatttcacaagaagtagcttcagagggtaactta1500 acagagtgtcagatctatcttgtcaatcccaacgttttacataaaataagagatccttta1560 gtgcacccagtgactgacattagcagcatctttaacacagccgtgtgttcaaatgtacag1620 tggtccttttcagagttggacttctagactcacctgttctcactccctgttttaattcaa1680 cccagccatgcaatgccaaataatagaattgctccctaccagctgaacagggaggagtct1740 gtgcagtttctgacacttgttgttgaacatggctaaatacaatgggtatcgctgagacta1800 agttgtagaaattaacaaatgtgctgcttggttaaaatggctacactcatctgactcatt1860 ctttattctattttagttggtttgtatcttgcctaaggtgcgtagtccaactcttggtat1920 taccctcctaatagtcatactagtagtcatactccctggtgtagtgtattctctaaaagc1980 tttaaatgtctgcatgcagccagccatcaaatagtgaatggtctctctttggctggaatt2040 acaaaactcagagaaatgtgtcatcaggagaacatcataacccatgaaggataaaagccc2100 caaatggtggtaactgataatagcactaatgctttaagatttggtcacactctcacctag2160 gtgagcgcattgagccagtggtgctaaatgctacatactccaactgaaatgttaaggaag2220 aagatagatccaaaaaaaaaaaaaaaaaa 2249 <210> 8 <211> 3583 <212> DNA
<213> Human <400>

gcttctaaagtgaagattcagttttcacttaaacaaccagcaagtcttgaagtctcttcc60 caagcaaatgggagcttctttggaccttggagcacacagaggattctactttctttaaaa120 ctttgttttcaggcaatttccctgagaaccgtttacttccagaagattggtggagcttga180 tctgaaggctggccatgaaatctcaaggtcaacattggtattccagttcagataaaaact240 gtaaagtgagctttcgtgagaagcttctgattattgattcaaacctgggggtccaagatg300 tggagaacctcaagtttctctgcataggattggtccccaacaagaagctggagaagtcca360 gctcagcctcagatgtttttgaacatctcttggcagaggatctgctgagtgaggaagacc420 ctttcttcctggcagaactcctctatatcatacggcagaagaagctgctgcagcacctca480 actgtaccaaagaggaagtggagcgactgctgcccacccgacaaagggtttctctgttta540 gaaacctgctctacgaactgtcagaaggcattgactcagagaacttaaaggacatgatct600 tccttctgaaagactcgcttcccaaaactgaaatgacctccctaagtttcctggcatttc660 tagagaaacaaggtaaaatagatgaagataatctgacatgcctggaggacctctgcaaaa720 cagttgtacctaaacttttgagaaacatagagaaatacaaaagagagaaagctatccaga780 tagtgacacctcctgtagacaag(~aagccgagtcgtatcaaggagaggaagaactagttt840 cccaaacagatgttaagacattcttggaagccttaccgagggcagctgtgtacaggatga900 atcggaaccacagaggcctctgtgtcattgtcaacaaccacagctttacctccctgaagg960 acagacaaggaacccataaagatgctgagatcctgagtcatgtgttccagtggcttgggt1020 tcacagtgcatatacacaataatgtgacgaaagtggaaatggagatggtcctgcagaagc1080 agaagtgcaatccagcccatgccgacggggactgcttcgtgttctgtattctgacccatg1140 ggagatttggagctgtctactcttcggatgaggccctcattcccattcgggagatcatgt1200 ctcacttcacagccctgcagtgccctagactggctgaaaaacctaaactctttttcatcc1260 aggcctgccaaggtgaagagatacagccttccgtatccatcgaagcagatgctctgaacc1320 ctgagcaggcacccacttccctgcaggacagtattcctgccgaggctgacttcctacttg1380 gtctggccactgtcccaggctatgtatcctttcggcatgtggaggaaggcagctggtata1440 ttcagtctctgtgtaatcatctgaagaaattggtcccaagacatgaagacatcttatcca1500 tcctcactgctgtcaacgatgatgtgagtcgaagagtggacaaacagggaacaaagaaac1560 agatgccccagcctgctttcacactaaggaaaaaactagtattccctgtgcccctggatg1620 cactttcaatatagcagagagtttttgttggttcttagacctcaaacgaatcattgggta1680 taacctccagcctcctgcccagcacaggaatcggtggtctccacctgtcattctagaaac1740 aggaaacaccgtgttttctgacacagtcaattctgattttctttttcttttgcaagtcta1800 aatgttagaaaactttctttttttggagatagtctcattctgtcacccagactggagtgc1860 aggggggcaatcacggctcactgtagtctcgacctcccaggctcaagctgtcctcccacc1920 tcagcctcccaagtagctgagactacaggtgtgtgtccatgcacagctaactttttattt1980 tttttgtggagatggggtttcactatgttgcctaagctggtctcaaactcctgggctcaa2040 gcgatcctcccacctcagcttctcaaagttctgggactacaggcatgaaatactgtgcct2100 ggcctggggaccaggtgcattttaaggttccttggtgttcaaaaaccacgttcttagcct2160 agattgagcttagattgcctctctagacaactaccccttagttataattctgtgtcccct2220 ctgcatgcccttaaacattggacagtgaggtcacagtccacccaccctctctctgatctc2280 ccccttcctaagacttctcttttgcacatctagtgaggtgaaaatttggtctatgccagg2340 cccatttcctgcttttgtgtaaggaaggtgctcacataggaagtttttatttggttagag2400 acaggtttccctgtaggaagatgatggctcatttacactcagctgctctgcaagcagaaa2460 ctttacaacctgatgtcatattccattttggactgggtgcggtgactcatgcctgtaatc2520 ccagtactctgggaagccaaggcaggcagatcacttgaggtcaggagttcgagaccagcc2580 tggccaatacggcaaaacctcatcattactaaaaacacaaaaattagccaggtgtggcgg2640 cgagcacctgtaatcccagctactcgggaggctgagacaggagaatctcttgaatccagg2700 aggcagaggctgtggtgagccaagatgacacaactgcactccagcttgggcaacagggcg2760 agaccttgtttaaaaaaaaaattcaatattggggttggaacatttcagttgccattgaca2820 gaacacccaattcaaattgactgaagcaaagaagggaatttattgcctctttcacattga2880 aacccaggagtggataacactggcttcaggcaaagcttgaatcaggactcaatctacagg2940 ccagcacctttctcttggccggatgtcctcagggctggcagatgcagtagactgcagtgg3000 acagtccccaccttgttactgctactacactttgctcctctggcccaaggcatgaggaga3060 gaggctgtgtcagaaactgaagctgttctcaggatcactgggctcttcttggcagagggg3120 atgtctggcttgcctgaagggagtggctctgtaaggacgccttgatgctttcttcattaa3180 gattttgagcatttttacgtacttgagcttttttttttttttttttcaatttctagagga3240 actttttctctgttaattcctggaactgtattttgaatccttaaaggtgagccctcatag3300 ggagatccaaagtcctgtggttaacgccttcatttatagatgaggcagctgaggcctggg3360 gatgtgaacaacctgctcacagtcctcatttactggatttgacttcagccaggtgaactg3420 gaatgccttg gggcgtggaa gggcattagg agtgtttcat ttgatatgtg aatgctcata 3480 aaaaaatgtc aaggaatgaa gaacaacaac tctcagtggt gcctgcattt ataattattt 3540 atgtgaaagt caaattcatg tacagtaaat ttgttataag aat 3583 <210> 9 <21l> 5516 <2l2> DNA
<213> Human <400>

ccggccggaattccggctggatttcctcccggacatgacggtcgagggccgcctgctcgt60 tcctgacagaattaacggcacagccaacaagatgaacggagctttggatcactcagacca120 accagacccagatgccattaagatgtttgtcggacagatcccccggtcatggtcggaaaa180 ggagctgaaagaactttttgagccttacggagccgtctaccagatcaacgtcctccggga240 ccggagtcagaaccctccgcagagtaaaggttgttgtttcgtaacattttatacaagaaa300 agctgcacttgaggcccagaatgcactgcacaatattaaaactttacctgggatgcatca360 tcccattcagatgaaacctgcagatagtgaaaagtccaacgctgtggaagacagaaaatt420 gttcataggaatggtttcgaagaaatgtaatgagaacgacatcagggtgatgttctctcc480 atttggccagatagaagaatgccggatcctccggggacctgatgggctgagtcgaggctg540 tgcgtttgtcacattttctacaagggcaatggcacagaatgcaatcaaagccatgcatca600 gtctcagaccatggagggctgctcttcacctatcgtggtgaagtttgctgacactcagaa660 ggacaaagagcaaaggcgcctccagcagcagctcgctcagcagatgcagcagctcaacac720 tgccacctgggggaacctgacagggctgggcggactgaccccacagtatctggcgctcct780 gcagcaggccacctcctccagcaacctgggtgcgttcagcggcattcaacaaatggcagg840 catgaatgctttacagttgcagaacctggcgacgctggctgctgctgcagctgcggccca900 gacctcagccaccagcaccaatgcaaaccctctctctaccacgagcagcgccctgggagc960 cctcacgagtcccgtggctgcttcaacccccaactccactgctggtgcagccatgaactc1020 cttgacctctctcgggactctgcaaggactggctggagccactgttggactgaataatat1080 taatgcactagcagttgctcaaatgctctcaggtatggcggctctgaatggaggacttgg1140 cgccacaggcttgacgaatggcacggctggcaccatggacgccctcacccaggcctactc1200 aggaattcaacagtacgcagccgccgcgctgcccactctgtacagccagagcctgctgca1260 gcagcagagcgctgcaggcagccagaaggaaggtccagagggggcaaacctctttattta1320 ccaccttccacaggaatttggagaccagcacattctgcagatgttcatgccttttggaaa1380 tgttatctct gctaaagtct tcattgacaa acagaccaat ctgagcaagt gctttggttt 1440 tgttagctac gacaatccag tctctgcaca agctgctatc caagctatga atggctttca 1500 gatcggcatgaaacgcttgaaggtgcagctgaagcgttccaaaaacgacagcaaacctta1560 ctgatcctaaccccagaggctccctgctctcattttagctttcttaggacatcttcatgc1620 ccgttagttcatcgtttgcctagcatgtccctgtggcgtctcaaaaaaaagtttcatcgt1680 cccgtcattgtttctgatgtctttctgacctcacatcatatttggttctcctactgacct1740 ttgatctagtttgacctttgaaatttgcatgtgacctcatctagctatgaattctgggaa1800 gtcaatgtgaaaaacattgctgcattcatgcaagactgaaatttattattagacaaattc1860 attatagaaaaaacctgtggcaaaaacgtttctttcttattttttttcttttcctaaaac1920 agacttgaaagtattatacagggattggcattcttcccggtcactggtaacaatagcaat1980 atgtgtccagggacacagaatgttggtttctaacagactacttccaaaaacagtttgaga2040 aaaaaactgtctgattttaagtctctagaggtctgtaatagtttttacatttttcaggca2100 gtgtaaagttttttgataaggccattttaggtggctcactttctcattaagatatatata2160 tagaaccactttttgtagattagtataagaaaaatatttaccctgttttggggcaaatgc2220 tacctatttgtgtcaccttttgctgaactcacagttagacaatccatggtttaatgcaca2280 tgaaattacctatattttatactgtttcaatgtacaggagaaaggttactgtaaactgtg2340 ttatgttggtgcttctgtgaattaagttgtggtttcatcatgagtcttaatgttctttgt2400 tgataagacaagtttagaattggtttacttaatacaaaaaaaaaaaaaagaatttcaaaa2460 aaaaaagttgtttgcttaaaaaaaatttcatgtgagggaaaaaaaaaaaaacctattcca2520 gaataagttttgtgttggcttgtgaagcattgatgtcattttttttaattgtggactatt2580 tagatgtgtttgtgttcagcaaaatgtgatctgtttttttcttttaaagaaaaaaagtga2640 aaatatatagtgccaaattccaaaggtacttccttcctagagcttcagtgtgtttcttgt2700 gagaagtaatttgataacatgggtattttattatgtgttttgtataaatccctaatattt2760 aaaaaaaaaaacaaaacaaaaaaaggttacaaagtttgttaacttgctatcctgtggtct2820 tgttgcctgaaattgttattgtttgttatttctctctgatgttttttgtaagacattgta2880 taagtgcccatgtcccacttttttaaccactccgcacatcagtgctgtgaaggcaacctc2940 accatgtattttcttcataatctatggaaacctctaaggtgagaaagttttgaactttta3000 accctttctacccagagctatctggaatgttgatgactttttatactgtcatgatttgag3060 tttgttttggggtgtttccaatttggatttttttccctgcatctatcctctaagttgttt3120 cggtttgactactttgttctttggttaagatccaaaagaaaacagaaaacaattccacga3180 ggccaatcta aagggaaaaa atcctacact acttttacta cttttgatta tttctcattt 3240 ttgggaaaag aattcctaat gtgctactag aattccttct tcagttttaa cgagtaattg 3300 gataaaccct gagggaaaac ggaggtagat tcagcaccta acaatcctgt atgcttttga 3360 gatcacgttt agtgctatgt cctagtctag aatattttca tataccttgc agtaaaacca 3420 ctttgtggca ggacagtctc ttgaggggtt ttgtttctgt ttcctaaata ctcctaaata 3480 atatttctaa tcagccatta tgctggggca tctctgatcc cagtaggtac ctctgaatat 3540 accaggtgtc tggagttaga agcccatagc cctttcccag cctttttggt ttttttaatt 3600 gaacacattt catctaagta aagctcagtt ctttatcaca atttactgac caaataccta 3660 gcaccagttc ctgctgccac tttttaaagt gccatatgac tttctacgaa caggtacctt 3720 gctgtcttga caaatcctaa tgtcacgcct acagccccaa cacaagctcc agtcttcctc 3780 ttcggcatgc cctggaagct tcttggcctc agctcccctt ccccgctcag caccctgtta 3840 ggatcagtgt gtgtggatgg gatagccctg ggatggaaag gactagcctc tactgatgca 3900 aaaaaacaaa aagcaacaca aacgtttcct tcttatagca catgcacttc cttacaatga 3960 catgatttgt attatcctca catgtgttta ctactgctgg ggccttcctt catcctctga 4020 gggctatttt gtactttctg cagcaatcag cttaataaca acacttattg cacctgtctc' 4080 tctctgagaa cacggtgtgt ctcgacacgt accacgtaac gtggaaacac aagagcccac 4140 cacttgaatt tctaagacca tttcattctg aaacttctta tcaattacct aaatctcaac 4200 gaaaaacaat ttactgaagc cgactcccct ccccatctcc ctctcaacct caacccacct 4260 gcatgcatctcccccagaggaaaacactgagggtaggggacagggaggctcaggacgcgc4320 cctctgaatcggagtgtttcttcttcacaagtcaccaagagaggacatgagggggaaagt4380 ccttttttgcccttctccaaaaaataaccttccacagagacaaactgtccttctatccac4440 ttttatcttttaataaatatcaaaaggaaaaagctgcaagggtgcaaagggcctgtgcca4500 gaagaaaacacacacagggaaaccgctttttttaatcaattgtagagaatagtcattttt4560 aatctaaattagagaattgtgatacaatggcagtcctcaaaggcgtaacgagttcatctt4620 tctttcaccataggggttatagttggcttgtgctactctggaatcattttactgtttgtt4680 tttattatcttaagtgctaattaaaaaaaaaataaaattttaaaaaaacctgtagtttca4740 ttacctttttgaataatgtcatacaaaaaatgtatttgtttttttgtgctgtgagaattg4800 atgtttgtagattaataatcattttgtttagaattacaaaatagtttttaaatattgtct4860 gagaaaagccaaagttaatgcaacctagtggaaactgtaagaccatttgagtattgtttg4920 ttttattgat gcatttggat tttgttgttt gatggaattt gagccaaaaa aaaaaatacg 4980 caggctttcc tatttctaca actgattgta cttatgcatt ttgtaccagt ggaacttttt 5040 atactggagattaaaaaaaaaatggaaatttttgtggcttgctctggtgggcccctgaca5100 atgactgatttcaagtttgatttcgggttgattgattgattgattgatagaaagaaagtt5160 gcttttcttttgagaattaaaaactttggcttgatttcttttttccctttgcttatatct5220 agcattagaattttgtcttaaaataacagcggtaagtttcactttttattctgtattgtg5280 cagttacacaataaggtaattagatttagaagtactcagtcactttaagtggataaatgt5340 attagttaaaactttagggtttgcttttttgctgtttagatcaaagttttttctgattct5400 tctgtcctcattgtgaacataaccgtgtagttgaaacagtcaaacttatttttgtaatgt5460 atgttattgtgtgatgcagtttttttgcttctgtctccaatattaaaccattttcc 5516 <210> 10 <211> 736 <212> DNA
<213> Human <400>

ggctctcaccctcctctcctgcagctccagctttgtgctctgcctctgaggagaccatgg 60 cccggcctctgtgtaccctgctactcctgatggctaccctggctggggctctggcctcga 120 gctccaaggaggagaataggataatcccaggtggcatctatgatgcagacctcaatgatg 180 agtgggtacagcgtgcccttcacttcgccatcagcgagtacaacaaggccaccgaagatg 240 agtactacagacgcccgctgcaggtgctgcgagccagggagcagacctttgggggggtga 300 attacttcttcgacgtagaggtgggccgcaccatatgtaccaagtcccagcccaacttgg 360 acacctgtgccttccatgaacagccagaactgcagaagaaacagttgtgctctttcgaga 420 r tctacgaagttccctgggaggacagaatgtccctggtgaattccaggtgtcaagaagcct 480 aggggtctgtgccaggccagtcacaccgaccaccacccactcccacccactgtagtgctc 540 ccacccctggactggtggcccccaccctgcgggaggcctccccatgtgcctgtgccaaga 600 gacagacagagaaggctgcaggagtcctttgttgctcagcagggcgctctgccctccctc 660 cttccttcttgcttctaatagacctggtacatggtacacacacccccacctcctgcaatt 720 aaacagtagc atcgcc 736 <210> 11 <211> 6129 <212> DNA
<213> Human <400>

aattggaagcaaatgacatcacagcaggtcagagaaaaagggttgagcggcaggcaccca 60 gagtagtaggtctttggcattaggagcttgagcccagacggccctagcagggaccccagc 120 gcccgagaga~ccatgcagaggtcgcctctggaaaaggccagcgttgtctccaaacttttt 180 ttcagctggaccagaccaattttgaggaaaggatacagacagcgcctggaattgtcagac 240 atataccaaatcccttctgttgattctgctgacaatctatctgaaaaattggaaagagaa 300 tgggatagagagctggcttcaaagaaaaatcctaaactcattaatgcccttcggcgatgt 360 tttttctggagatttatgttctatggaatctttttatatttaggggaagtcaccaaagca 420 gtacagcctctcttactgggaagaatcatagcttcctatgacccggataacaaggaggaa 480 cgctctatcgcgatttatctaggcataggcttatgccttctctttattgtgaggacactg 540 ctcctacacccagccatttttggccttcatcacattggaatgcagatgagaatagctatg 600 tttagtttgatttataagaagactttaaagctgtcaagccgtgttctagataaaataagt 660 attggacaacttgttagtctcctttccaacaacctgaacaaatttgatgaaggacttgca 720 ttggcacatttcgtgtggatcgctcctttgcaagtggcactcctcatggggctaatctgg 780 gagttgttacaggcgtctgccttctgtggacttggtttcctgatagtccttgcccttttt 840 caggctgggctagggagaatgatgatgaagtacagagatcagagagctgggaagatcagt 900 gaaagacttgtgattacctcagaaatgattgaaaatatccaatctgttaaggcatactgc 960 tgggaagaagcaatggaaaaaatgattgaaaacttaagacaaacagaactgaaactgact 1020 cggaaggcagcctatgtgagatacttcaatagctcagccttcttcttctcagggttcttt 1080 gtggtgtttttatctgtgcttccctatgcactaatcaaaggaatcatcctccggaaaata 1140 ttcaccaccatctcattctgcattgttctgcgcatggcggtcactcggcaatttccctgg 1200 gctgtacaaacatggtatgactctcttggagcaataaacaaaatacaggatttcttacaa 1260 aagcaagaatataagacattggaatataacttaacgactacagaagtagtgatggagaat 1320 gtaacagccttctgggaggagggatttggggaattatttgagaaagcaaaacaaaacaat 1380 aacaatagaaaaacttctaatggtgatgacagcctcttcttcagtaatttctcacttctt 1440 ggtactcctgtcctgaaagatattaatttcaagatagaaagaggacagttgttggcggtt 1500 gctggatccactggagcaggcaagacttcacttctaatgatgattatgggagaactggag 1560 ccttcagagggtaaaattaagcacagtggaagaatttcattctgttctcagttttcctgg 1620 attatgcctggcaccattaaagaaaatatcatctttggtgtttcctatgatgaatataga 1680 tacagaagcgtcatcaaagcatgccaactagaagaggacatctccaagtttgcagagaaa 1740 gacaatatagttcttggagaaggtggaatcacactgagtggaggtcaacgagcaagaatt1800 tctttagcaagagcagtatacaaagatgctgatttgtatttattagactctccttttgga1860 tacctagatgttttaacagaaaaagaaatatttgaaagctgtgtctgtaaactgatggct1920 aacaaaactaggattttggtcacttctaaaatggaacatttaaagaaagctgacaaaata1980 ttaattttgaatgaaggtagcagctatttttatgggacattttcagaactccaaaatcta2040 cagccagactttagctcaaaactcatgggatgtgattctttcgaccaatttagtgcagaa2100 agaagaaattcaatcctaactgagaccttacaccgtttctcattagaaggagatgctcct2160 gtctcctggacagaaacaaaaaaacaatcttttaaacagactggagagtttggggaaaaa2220 aggaagaattctattctcaatccaatcaactctatacgaaaattttccattgtgcaaaag2280 actcccttacaaatgaatggcatcgaagaggattctgatgagcctttagagagaaggctg2340 tccttagtaccagattctgagcagggagaggcgatactgcctcgcatcagcgtgatcagc2400 actggcccca cgcttcaggc acgaaggagg cagtctgtcc tgaacctgat gacacactca 2460 gttaaccaag gtcagaacat tcaccgaaag acaacagcat ccacacgaaa agtgtcactg 2520 gcccctcagg caaacttgac tgaactggat atatattcaa gaaggttatc tcaagaaact 2580 ggcttggaaataagtgaagaaattaacgaagaagacttaaaggagtgcctttttgatgat2640 atggagagcataccagcagtgactacatggaacacataccttcgatatattactgtccac2700 aagagcttaatttttgtgctaatttggtgcttagtaatttttctggcagaggtggctgct2760 tctttggttgtgctgtggctccttggaaacactcctcttcaagacaaagggaatagtact2820 catagtagaaataacagctatgcagtgattatcaccagcaccagttcgtattatgtgttt2880 tacatttacgtgggagtagccgacactttgcttgctatgggattcttcagaggtctacca2940 ctggtgcatactctaatcacagtgtcgaaaattttacaccacaaaatgttacattctgtt3000 cttcaagcacctatgtcaaccctcaacacgttgaaagcaggtgggattcttaatagattc3060 tccaaagatatagcaattttggatgaccttctgcctcttaccatatttgacttcatccag3120 ttgttattaattgtgattggagctatagcagttgtcgcagttttacaaccctacatcttt3180 gttgcaacagtgccagtgatagtggcttttattatgttgagagcatatttcctccaaacc3240 tcacagcaactcaaacaactggaatctgaaggcaggagtccaattttcactcatcttgtt3300 acaagcttaaaaggactatggacacttcgtgccttcggacggcagccttactttgaaact3360 ctgttccacaaagctctgaatttacatactgccaactggttcttgtacctgtcaacactg3420 cgctggttccaaatgagaatagaaatgatttttgtcatcttcttcattgctgttaccttc3480 atttccattttaacaacaggagaaggagaaggaagagttggtattatcctgactttagcc3540 atgaatatca tgagtacatt gcagtgggct gtaaactcca gcatagatgt ggatagcttg 3600 atgcgatctg tgagccgagt ctttaagttc attgacatgc caacagaagg taaacctacc 3660 aagtcaaccaaaccatacaagaatggccaactctcgaaagttatgattattgagaattca3720 cacgtgaagaaagatgacatctggccctcagggggccaaatgactgtcaaagatctcaca3780 gcaaaatacacagaaggtggaaatgccatattagagaacatttccttctcaataagtcct3840 ggccagagggtgggcctcttgggaagaactggatcagggaagagtactttgttatcagct3900 tttttgagactactgaacactgaaggagaaatccagatcgatggtgtgtcttgggattca3960 ataactttgcaacagtggaggaaagcctttggagtgataccacagaaagtatttattttt4020 tctggaacatttagaaaaaacttggatccctatgaacagtggagtgatcaagaaatatgg4080 aaagttgcagatgaggttgggctcagatctgtgatagaacagtttcctgggaagcttgac4140 tttgtccttgtggatgggggctgtgtcctaagccatggccacaagcagttgatgtgcttg4200 gctagatctgttctcagtaaggcgaagatcttgctgcttgatgaacccagtgctcatttg4260 gatccagtaacataccaaataattagaagaactctaaaacaagcatttgctgattgcaca4320 gtaattctctgtgaacacaggatagaagcaatgctggaatgccaacaatttttggtcata4380 gaagagaacaaagtgcggcagtacgattccatccagaaactgctgaacgagaggagcctc4440 ttccggcaagccatcagcccctccgacagggtgaagctctttccccaccggaactcaagc4500 aagtgcaagtctaagccccagattgctgctctgaaagaggagacagaagaagaggtgcaa4560 gatacaaggctttagagagcagcataaatgttgacatgggacatttgctcatggaattgg4620 agctcgtgggacagtcacctcatggaattggagctcgtggaacagttacctctgcctcag4680 aaaacaaggatgaattaagtttttttttaaaaaagaaacatttggtaaggggaattgagg4740 acactgatatgggtcttgataaatggcttcctggcaatagtcaaattgtgtgaaaggtac4800 ttcaaatccttgaagatttaccacttgtgttttgcaagccagattttcctgaaaaccctt4860 gccatgtgctagtaattggaaaggcagctctaaatgtcaatcagcctagttgatcagctt4920 attgtctagtgaaactcgttaatttgtagtgttggagaagaactgaaatcatacttctta4980 gggttatgattaagtaatgataactggaaacttcagcggtttatataagcttgtattcct5040 ttttctctcctctccccatgatgtttagaaacacaactatattgtttgctaagcattcca5100 actatctcat ttccaagcaa gtattagaat accacaggaa ccacaagact gcacatcaaa 5160 atatgcccca ttcaacatct agtgagcagt caggaaagag aacttccaga tcctggaaat 5220 cagggttagt attgtccagg tctaccaaaa atctcaatat ttcagataat cacaatacat 5280 cccttacctg ggaaagggct gttataatct ttcacagggg acaggatggt tcccttgatg 5340 aagaagttga tatgcctttt cccaactcca gaaagtgaca agctcacaga cctttgaact 5400 agagtttagc tggaaaagta tgttagtgca aattgtcaca ggacagccct tctttccaca 5460 gaagctccag gtagagggtg tgtaagtaga taggccatgg gcactgtggg tagacacaca 5520 tgaagtccaa gcatttagat gtataggttg atggtggtat gttttcaggc tagatgtatg 5580 tacttcatgc tgtctacact aagagagaat gagagacaca ctgaagaagc accaatcatg 5640 aattagtttt atatgcttct gttttataat tttgtgaagc aaaatttttt ctctaggaaa 5700 tatttattttaataatgtttcaaacatatattacaatgctgtattttaaaagaatgatta 5760 tgaattacatttgtataaaataatttttatatttgaaatattgactttttatggcactag 5820 tatttttatgaaatattatgttaaaactgggacaggggagaacctagggtgatattaacc 5880 aggggccatgaatcaccttttggtctggagggaagccttggggctgatcgagttgttgcc 5940 cacagctgtatgattcccagccagacacagcctcttagatgcagttctgaagaagatggt 6000 accaccagtctgactgtttccatcaagggtacactgccttctcaactccaaactgactct 6060 taagaagactgcattatatttattactgtaagaaaatatcacttgtcaataaaatccata 6120 catttgtgt 6129 <210> 12 <211> 1876 <212> DNA
<213> Human <400>

gagccatgctcgcggcgatgggctctctggcggctgccctctgggcagtggtccatcctc 60 ggactctcctactgggcactgtcgcctttctgctcgctgctgactttctcaaaagacggc 120 gcccaaagaactacccgccggggccctggcgcctgcccttccttggcaacttcttccttg 180 tggacttcgagcagtcgcacctggaggttcagctgtttgtgaagaaatatgggaaccttt 240 ttagcttggagcttggtgacatatctgcagttcttattactggcttgcccttaatcaaag 300 aagcccttatccacatggaccaaaactttgggaaccgccccgtgacccctatgcgagaac 360 atatctttaagaaaaatggattgattatgtcaagtggccaggcatggaaggagcaaagaa 420 ggttcactctgacagcactaaggaactttggtttaggaaagaagagcttagaggaacgca 480 ttcaggaggaggcccaacacctcactgaagcaataaaagaggagaacggacagccttttg 540 accctcatttcaagatcaacaatgcagtttccaatatcatttgctccatcaccttcggag 600 aacgctttgagtaccaggatagttggtttcagcagctgctgaagttactagatgaagtca 660 catacttggaggcttcaaagacatgccagctctacaatgtctttccatggataatgaaat720 tcctgcctggaccccaccaaactctcttcagcaactggaaaaaactgaaattgtttgttt780 ctcatatgattgacaaacacagaaaggattggaatcctgcagaaacaagagactttattg840 atgcttaccttaaagaaatgtcaaagcacacaggcaatcctacttcaagtttccatgaag900 aaaacctcatctgcagcaccctggacctcttctttgccggaaccgagacaacttccacaa960 ctctgcgatgggctctgctttatatggccctctacccagaaatccaagaaaaagtacaag1020 ctgagattgacagagtgattggccaggggcagcagccgagcacagccgcccgggagtcca1080 tgccctacaccaatgctgtcatccatgaggtgcagagaatgggcaacatcatccccctga1140 acgttcccagggaagtgacagttgataccactttggctgggtaccacctgcccaagggta1200 ccatgatcctgaccaatttgacggcgctgcacagggaccccacagagtgggccacccctg1260 acacattcaatccggaccattttctggagaatggacagtttaagaaaagggaagccttta1320 tgcctttctcaataggaaagcgggcatgcctcggagaacagttggccaggactgagctgt1380 ttattttcttcacttcccttatgcaaaaatttaccttcaggcccccaaacaatgagaagc1440 tgagcctgaagtttagaatgggtatcaccatttccccagtcagtcaccgcctctgcgctg1500 ttcctcaggtgtaatattgttaagaaagaaaggggcaaggaaagtaagaagacatggcac1560 gtgttctgaaaccactggtgtctgctcagatgtgttgggacaaaatgaaagtgactttca1620 agaaagatcagaggaatttgactcagagaaaactagatccaaatcccagctctactgtct1680 cgtccgaattagccttgggaaaatcatttatatgctaaataatttacctttttatctagg1740 agatgaaaagaggataatgtttccttccataaagaaagttcttgtaagaatcaaaagaaa1800 tggtgagctttaagtggtttgtaaaccataaaacacatcataaaagttctatctataaaa1860 aaaaaaaaaaaaaaaa 1876 <210> 13 <211> 2375 <212> DNA
<2l3> Human <400>

atgaagacaccgtggagggttctcctgggactgctgggtgctgctgcgcttgtcaccatc60 atcaccgtgcccgtggttctgctgaacaaaggcacagatgatgctacagctgacagtcgc120 aaaacttacactctaactgattacttaaaaaatacttatagactgaagttatactcctta180 agatggatttcagatcatgaatatctctacaaacaagaaaataatatcttggtattcaat240 gctgaatatggaaacagctcagttttcttggagaacagtacatttgatgagtttggacat300 tctatcaatgattattcaatatctcctgatgggcagtttattctcttagaatacaactac 360 gtgaagcaatggaggcattcctacacagcttcatatgacatttatgatttaaataaaagg 420 cagctgattacagaagagaggattccaaacaacacacagtgggtcacatggtcaccagtg 480 ggtcataaattggcatatgtttggaacaatgacatttatgttaaaattgaaccaaattta 540 ccaagttacagaatcacatggacggggaaagaagatataatatataatggaataactgac 600 tgggtttatgaagaggaagtcttcagtgcctactctgctctgtggtggtctccaaacggc 660 acttttttagcatatgcccaatttaacgacacagaagtcccacttattgaatactccttc 720 tactctgatgagtcactgcagtacccaaagactgtacgggttccatatccaaaggcagga780 gctgtgaatccaactgtaaagttctttgttgtaaatacagactctctcagctcagtcacc840 aatgcaacttccatacaaatcactgctcctgcttctatgttgataggggatcactacttg900 tgtgatgtgacatgggcaacacaagaaagaatttctttgcagtggctcaggaggattcag960 aactattcggtcatggatatttgtgactatgatgaatccagtggaagatggaactgctta1020 gtggcacggcaacacattgaaatgagtactactggctgggttggaagatttaggccttca1080 gaacctcattttacccttgatggtaatagcttctacaagatcatcagcaatgaagaaggt1140 tacagacacatttgctatttccaaatagataaaaaagactgcacatttattacaaaaggc1200 acctgggaagtcatcgggatagaagctctaaccagtgattatctatactacattagtaat1260 gaatataaaggaatgccaggaggaaggaatctttataaaatccaacttagtgactataca1320 aaagtgacatgcctcagttgtgagctgaatccggaaaggtgtcagtactattctgtgtca1380 ttcagtaaagaggcgaagtattatcagctgagatgttccggtcctggtctgcccctctat1440 actctacacagcagcgtgaatgataaagggctgagagtcctggaagacaattcagctttg1500 gataaaatgctgcagaatgtccagatgccctccaaaaaattggacttcattattttgaat1560 gaaacaaaattttggtatcagatgatcttgcctcctcattttgataaatccaagaaatat1620 cctctactattagatgtgtatgcaggcccatgtagtcaaaaagcagacattgtcttcaga1680 ctgaactgggccacttaccttgcaagcacagaaaacattatagtagctagctttgatggc1740 agaggaagtggttaccaaggagataagatcatgcatgcaatcaacagaagactgggaaca1800 tttgaagttgaagatcaaattgaagcagccagacaattttcaaaaatgggatttgtggac1860 aacaaacgaattgcaatttggggctggtcatatggagggtacgtaacctcaatggtcctg1920 ggatcgggaagtggcgtgttcaagtgtggaatagccgtggcgcctgtatcccggtgggag1980 tactatgagtcagtgtacacagaacgttacatgggtctcccaactccagaagacaacctt2040 gaccattacagaaattcaacagtcatgagcagagctgaaaattttaaacaagttgagtac2100 ctccttattc atggaacagc agatgataac gttcactttc agcagtcagc tcagatctcc 2160 aaagccctgg tcgatgttgg agtggatttc caggcaatgt ggtatactga tgaagaccat 2220 ggaatagcta gcagcacagc acaccaacat atatataccc acatgagcca cttcataaaa 2280 caatgtttct ctttacctta gcacctcaaa atactatgcc atttaaagct tattaaaact 2340 catttttgtt ttcattatct caaaaaaaaa aaaaa 2375 <210>

<211>

<212>
DNA

<213> n Huma <400>

cccagcgccccggaagtgatctgtggcggctgctgcagagccgccaggaggagggtggat60 CtCCCCagagcaaagcgtcggagtcctcctCCtCCttCtCCtCCt tCCt CCtCCt120 CCtCC

ccagccgcccaggctcccccgccacccgtcagactcctccttcgaccgctcccggcgcgg180 ggccttccaggcgacaaggaccgagtaccctccggccggagccacgcagccgcggcttcc240 ggagccctcggggcggcggactggctcgcggtgcaggtaaagctccagatggctctggaa300 cttatgaggaaagagttggaggacgccttgactcaggaggccaacgtggggaaaaagact360 gtcatttggaaggagaaagtggaaatgcagaggcagcgcttcagattggagtttgagaag420 catcgtggctttctggcccaggaggagcaacggcagctgaggcggctggaggcggaggag480 cgagcgacgctgcagagactgcgggagagcaagagccggctggtccagcagagcaaggcc540 ctgaaggagctggcggatgagctgcaggagaggtgccagcgcccagccctgggtctgctg600 gagggtgtgagaggagtcctgagcagaagtaaggctgtcacaaggctggaagcagagaac660 atccccatggaactgaagacagcatgctgcatccctgggaggagggagctcttaaggaag720 ttccaagtggatgtaaagctggatcccgccacggcgcacccgagtctgctcttgaccgcc780 gacctgcgcagtgtgcaggatggagaaccatggagggatgtccccaacaaccctgagcga840 tttgacacatggccctgcatcctgggtttgcagagcttctcatcagggaggcattactgg900 gaggttctggtgggagaaggagcagagtggggtttaggggtctgtcaagacacactgcca960 agaaagggggaaaccatgccatctcctgagaatggggtctgggccctgtggctgctgaaa1020 gggaatgagtacatggtccttgcctccccatcagtgcctcttctccaactggaaagtcct1080 cgctgcattgggattttcttggactatgaagccggtgaaatttcattctacaatgtcaca1140 gatggatcttatatctacacattcaaccaactcttctctggtcttcttcggccttacttt1200 ttcatctgtgatgcaactcctcttatcttgccacccacgacaatagcagggtcaggaaat1260 tgggcatccagggatcatttagatcctgcttctgatgtaagagatgatcatctctaaaat1320 tctgttcccaagatgcagtcctagcgtagcgaacgttcctggagtggggtgaaggatatc1380 aatatactaagttttaacagataccccatttaggtcagcacttgattcgttgttgctgtg1440 aaatatgtccatgggacaaaagagggaatatgaaatatttgcatatgggaagattataga1500 gcataataattttgtaaatggagcaatctcaacctctatttctagatcacattttcttga1560 tgtcttccttcaaattaatgaccttggattacataaggatttctatgcattcattataat1620 ttgttattcctttcaatatccttgtatttcaaatcttccatataagaattagacatggca1680 attcttaaattgattcagaatggtctgatactattccagtatcacctccttaattctgtt1740 tCtCCt ttCCtgattttCCttCtCattCt CtCCttCCCCgCtCtgtCtCtCtCtCC1800 Cgtt ctgtcactctctctctctcgttccttattttttgtttcttacctcttactgtttaacctg1860 ttgcttccttctggattaatacatttagagccattcctttatatggtcacatttcctatg1920 actttactcaattacttttaaaatcctttctattctgagactaatttttaagaattacaa1980 agctcattcttctgaatctaatatcactaactcctagactttttccgttttctttggata2040 cactttaagtaggaatttatcagaattttcattcaactcgttctttaatgcagatattta2100 ctggttataagaccttaaggctgggtgcagtggctcacgcctgtggtcccagcgctttgg2160 ggggctgaggcgggtggatcacaggctcgggagttcggggccagcctggccagcatggtg2220 aaaccctgtctctactagaaaaaaaaaa 2248 <210> 15 <211> 330 <212> DNA
<213> Human <400>

gcggccgcaggtacccgggctccacgtcagggtagacctggcgtccctcaatgccttcca60 tgtagttggccacgtaatccaccatctccttccctctccttcggaattcacttgcgttca120 tggtgtctgggctctgtcagaggtgaaaaatgctggaaattcgaattccttacagggcta180 ctctccttgatgggattctccaactttggggactgaagagcatgtggagaagctgctgag240 gcactcggcactgagacagtcactcttcttgaaactccaagccacacgtttccctcttct300 tgcatttccagccacatgtgcccctcgtgc 330 <210> 16 <211> 3370 <212> DNA
<213> Human <400> 16 gcccccgccc ggcccgcccc gctctcctag tcccttgcaa cctggcgctg catccgggcc 60 actgtcccaggtcccaggtcccggcccggagctatggagcggcgctggcccctggggcta120 gggctggtgctgctgctctgcgccccgctgcccccgggggcgcgcgccaaggaagttact180 ctgatggacacaagcaaggcacagggagagctgggctggctgctggatcccccaaaagat240 gggtggagtgaacagcaacagatactgaatgggacacccctctacatgtaccaggactgc300 ccaatgcaaggacgcagagacactgaccactggcttcgctccaattggatctaccgcggg360 gaggaggcttcccgcgtccacgtggagctgcagttcaccgtgcgggactgcaagagtttc420 cctgggggagccgggcctctgggctgcaaggagaccttcaaccttctgtacatggagagt480 gaccaggatgtgggcattcagctccgacggcccttgttccagaaggtaaccacggtggct540 gcagaccagagcttcaccattcgagaccttgcgtctggctccgtgaagctgaatgtggag600 cgctgctctctgggccgcctgacccgccgtggcctctacctcgctttccacaacccgggt660 gcctgtgtggccctggtgtctgtccgggtcttctaccagcgctgtcctgagaccctgaat720 ggcttggcccaattcccagacactctgcctggccccgctgggttggtggaagtggcgggc780 acctgcttgccccacgcgcgggccagccccaggccctcaggtgcaccccgcatgcactgc840 agccctgatggcgagtggctggtgcctgtaggacggtgccactgtgagcctggctatgag900 gaaggtggcagtggcgaagcatgtgttgcctgccctagcggctcctaccggatggacatg960 gacacaccccattgtctcacgtgcccccagcagagcactgctgagtctgagggggccacc1020 atctgtacctgtgagagcggccattacagagctcccggggagggcccccaggtggcatgc1080 acaggtcccccctcggccccccgaaacctgagcttctctgcctcagggactcagctctcc1140 ctgcgttgggaacccccagcagatacggggggacgccaggatgtcagatacagtgtgagg1200 tgttcccagtgtcagggcacagcacaggacggggggccctgccagccctgtggggtgggc1260 gtgcacttctcgccgggggcccgggcgctcaccacacctgcagtgcatgtcaatggcctt1320 gaaccttatgccaactacacctttaatgtggaagcccaaaatggagtgtcagggctgggc1380 agctctggccatgccagcacctcagtcagcatcagcatggggcatgcagagtcactgtca1440 ggcctgtctctgagactggtgaagaaagaaccgaggcaactagagctgacctgggcgggg1500 tcccggccccgaagccctggggcgaacctgacctatgagctgcacgtgctgaaccaggat1560 gaagaacggtaccagatggttctagaacccagggtcttgctgacagagctgcagcctgac1620 accacataca tcgtcagagt ccgaatgctg accccactgg gtcctggccc tttctcccct 1680 gatcatgagt ttcggaccag cccaccagtg tccaggggcc tgactggagg agagattgta 1740 gccgtcatctttgggctgctgcttggtgcagccttgctgcttgggattctcgttttccgg1800 tccaggagagcccagcggcagaggcagcagaggcacgtgaccgcgccaccgatgtggatc1860 gagaggacaagctgtgctgaagccttatgtggtacctccaggcatacgaggaccctgcac1920 agggagccttggactttacccggaggctggtctaattttccttcccgggagcttgatcca1980 gcgtggctgatggtggacactgtcataggagaaggagagtttggggaagtgtatcgaggg2040 accctcaggctccccagccaggactgcaagactgtggccattaagaccttaaaagacaca2100 tccccaggtggccagtggtggaacttccttcgagaggcaactatcatgggccagtttagc2160 cacccgcatattctgcatctggaaggcgtcgtcacaaagcgaaagccgatcatgatcatc2220 acagaatttatggagaatgcagccctggatgccttcctgagggagcgggaggaccagctg2280 gtccctgggcagctagtggccatgctgcagggcatagcatctggcatgaactacctcagt2340 aatcacaattatgtccaccgggacctggctgccagaaacatcttggtgaatcaaaacctg2400 tgctgcaaggtgtctgactttggcctgactcgcctcctggatgactttgatggcacatac2460 gaaacccagggaggaaagatccctatccgttggacagcccctgaagccattgcccatcgg2520 atcttcaccacagccagcgatgtgtggagctttgggattgtgatgtgggaggtgctgagc2580 tttggggacaagccttatggggagatgagcaatcaggaggttatgaagagcattgaggat2640 gggtaccggttgccccctcctgtggactgccctgcccctctgtatgagctcatgaagaac2700 tgctgggcatatgaccgtgcccgccggccacacttccagaagcttcaggcacatctggag2760 caactgcttgccaacccccactccctgcggaccattgccaactttgaccccagggtgact2820 cttcgcctgcccagcctgagtggctcagatgggatcccgtatcgaaccgtctctgagtgg2880 ctcgagtccatacgcatgaaacgctacatcctgcacttccactcggctgggctggacacc2940 , atggagtgtgtgctggagctgaccgctgaggacctgacgcagatgggaatcacactgccc3000 gggcaccagaagcgcattctttgcagtattcagggattcaaggactgatccctcctctca3060 ccccatgcccaatcagggtgcaaggagcaaggacggggccaaggtcgctcatggtcactc3120 cctgcgccccttcccacaacctgccagactaggctatcggtgctgcttctgcccgcttta3180 aggagaaccctgctctgcaccccagaaaacctctttgttttaaaagggaggtgggggtag3240 aagtaaaaggatgatcatgggagggagctcaggggttaatatatatacatacatacacat3300 atatatattgttgtaaataaacaggaaatgattttctgcctccatcccacccatcagggc3360 tgcaggcact 3370 <210> 17 <211> 386 <212> DNA
<213> Human <220>
<221> misc_feature <222> (155)..(155) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (266)..(266) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (280)..(280) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (295)..(295) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (304)..(304) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (330)..(330) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (354)..(354) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (375)..(375) <223> n is a, c, g, or t <400> 17 gggaataagc ttgcgaccgc ttaattaaag atcttttttt tttttttttt ttttttttaa 60 gattcaagtc aaaattgttt tattgtcact cacatattta acataaaaag aaatgcagca 120 aatggctcag tatcgtattg aaaaaaaatc caggntgtgc agcttgttct attaacatct 180 gggagaagag ctgttcccac atcaggtcac agcagctgca gttctccaac gtccctttgc 240 agtacacagc cgtgggcaca cttggncaca gcccacgggn cagacaggta gcagncagct 300 cttnctttgc agggagggtg catttgcctn ctttgcactt gcagggagcc ggtncaggtt 360 ttagggagac acccnttggg tccagg 386 <210> 18 <211> 448 <212> DNA
<213> Human <400>

tttgaattggatattttttaatgcaaattgttgtttttcttcatttgtctactttattaa60 gctgtcctcaggccccaagaaacatactgtcccctcatttagaaacagactaactccgtt120 ttcctccactatcccctcccctgtccttgatctgtagatcctgttaagacaggaaaaaca180 gtgttggtcaaagggtacacgctttcagttacaagatgaacaagttctgaatacgtaaga240 tagaacatgggaggtgatgtggccgggtgcagtgactcacgcctgtaatcccagcacttt300 gggaggccgaggtgggcggatcatgaggtcaagggatcgagatcatcctggccaacatgg360 tgaaaccccgtctctactaaaaatacaaaaattagctgggcatggtggcacacgcctata420 gtcccagctacttaggaggctgaggcaa 448 <210> 19 <211> 4574 <212> DNA
<213> Human <400> 19 gagcgggcga gggagcgcgc gcggccgcca caaagctcgg gcgccgcggg gctgcatgcg 60 gcgtacctggcccggcgcggcgactgctctccgggctggcgggggccggccgcgagcccc120 gggggccccgaggccgcagcttgcctgcgcgctctgagccttcgcaactcgcgagcaaag180 tttggtggaggcaacgccaagcctgagtcctttcttcctctcgttccccaaatccgaggc240 agcccgcgggcgtcatgcccgcgctcctccgcagcctggggtacgcgctgaagcccggga300 ggcttggcgccggcgaagacccaaggaccactcttctgcgtttggagttgctccccacaa360 ccccgggctcgtcgctttctccatcccgacccagccggggcgcggggacaacacaggtcg420 cggaggagcgttgccattcaagtgactgcagcagcagcggcagcgcctcggttcctgagc480 ccaccgcaggctgaaggcattgcgcgtagtccatgcccgtagaggaagtgtgcagatggg540 attaacgtccacatggagatatggaagaggaccggggattggtaccgtaaccatggtcag600 ctggggtcgtttcatctgcctggtcgtggtcaccatggcaaccttgtccctggcccggcc660 ctccttcagtttagttgaggataccacattagagccagaagagccaccaaccaaatacca720 aatctctcaaccagaagtgtacgtggctgcgccaggggagtcgctagaggtgcgctgcct780 gttgaaagatgccgccgtgatcagttggactaaggatggggtgcacttggggcccaacaa840 taggacagtg cttattgggg agtacttgca gataaagggc gccacgccta gagactccgg 900 cctctatgct tgtactgcca gtaggactgt agacagtgaa acttggtact tcatggtgaa 960 tgtcacagat gccatctcat ccggagatga tgaggatgac accgatggtg cggaagattt 1020 tgtcagtgag aacagtaaca acaagagagc accatactgg accaacacag aaaagatgga 1080 aaagcggctccatgctgtgcctgcggccaacactgtcaagtttcgctgcccagccggggg1140 gaacccaatgccaaccatgcggtggctgaaaaacgggaaggagtttaagcaggagcatcg1200 cattggaggctacaaggtacgaaaccagcactggagcctcattatggaaagtgtggtccc1260 atctgacaagggaaattatacctgtgtggtggagaatgaatacgggtccatcaatcacac1320 gtaccacctggatgttgtggagcgatcgcctcaccggcccatcctccaagccggactgcc1380 ggcaaatgcctccacagtggtcggaggagacgtagagtttgtctgcaaggtttacagtga1440 tgcccagccccacatccagtggatcaagcacgtggaaaagaacggcagtaaatacgggcc1500 cgacgggctgccctacctcaaggttctcaagcactcggggataaatagttccaatgcaga1560 agtgctggctctgttcaatgtgaccgaggcggatgctggggaatatatatgtaaggtctc1620 caattatatagggcaggccaaccagtctgcctggctcactgtcctgccaaaacagcaagc1680 gcctggaagagaaaaggagattacagcttccccagactacctggagatagccatttactg1740 cataggggtcttcttaatcgcctgtatggtggtaacagtcatcctgtgccgaatgaagaa1800 cacgaccaagaagccagacttcagcagccagccggctgtgcacaagctgaccaaacgtat1860 ccccctgcggagacaggtaacagtttcggctgagtccagctcctccatgaactccaacac1920 cccgctggtgaggataacaacacgcctctcttcaacggcagacacccccatgctggcagg1980 ggtctccgagtatgaacttccagaggacccaaaatgggagtttccaagagataagctgac2040 actgggcaagcccctgggagaaggttgctttgggcaagtggtcatggcggaagcagtggg2100 aattgacaaagacaagcccaaggaggcggtcaccgtggccgtgaagatgttgaaagatga2160 tgccacagagaaagacctttctgatctggtgtcagagatggagatgatgaagatgattgg2220 gaaacacaagaatatcataaatcttcttggagcctgcacacaggatgggcctctctatgt2280 catagttgagtatgcctctaaaggcaacctccgagaatacctccgagcccggaggccacc2340 cgggatggagtactcctatgacattaaccgtgttcctgaggagcagatgaccttcaagga2400 cttggtgtcatgcacctaccagctggccagaggcatggagtacttggcttcccaaaaatg2460 tattcatcgagatttagcagccagaaatgttttggtaacagaaaacaatgtgatgaaaat2520 agcagactttggactcgccagagatatcaacaatatagactattacaaaaagaccaccaa2580 tgggcggctt ccagtcaagt ggatggctcc agaagccctg tttgatagag tatacactca 2640 tcagagtgat gtctggtcct tcggggtgtt aatgtgggag atcttcactt tagggggctc 2700 gccctaccca gggattcccg tggaggaact ttttaagctg ctgaaggaag gacacagaat 2760 ggataagcca gccaactgca ccaacgaact gtacatgatg atgagggact gttggcatgc 2820 agtgccctcc cagagaccaa cgttcaagca gttggtagaa gacttggatc gaattctcac 2880 tctcacaaccaatgaggaatacttggacctcagccaacctctcgaacagtattcacctag2940 ttaccctgacacaagaagttcttgttcttcaggagatgattctgttttttctccagaccc3000 catgccttacgaaccatgccttcctcagtatccacacataaacggcagtgttaaaacatg3060 aatgactgtgtctgcctgtccccaaacaggacagcactgggaacctagctacactgagca3120 gggagaccatgcctcccagagcttgttgtctccacttgtatatatggatcagaggagtaa3180 ataattggaaaagtaatcagcatatgtgtaaagatttatacagttgaaaacttgtaatct3240 tccccaggaggagaagaaggtttctggagcagtggactgccacaagccaccatgtaaccc3300 ctctcacctgccgtgcgtactggctgtggaccagtaggactcaaggtggacgtgcgttct3360 gccttccttgttaattttgtaataattggagaagatttatgtcagcacacacttacagag3420 cacaaatgcagtatataggtgctggatgtatgtaaatatattcaaattatgtataaatat3480 atattatatatttacaaggagttattttttgtattgattttaaatggatgtcccaatgca3540 cctagaaaattggtctctctttttttaatagctatttgctaaatgctgttcttacacata3600 atttcttaattttcaccgagcagaggtggaaaaatacttttgctttcagggaaaatggta3660 taacgttaatttattaataaattggtaatatacaaaacaattaatcatttatagtttttt3720 ttgtaatttaagtggcatttctatgcaggcagcacagcagactagttaatctattgcttg3780 gacttaactagttatcagatcctttgaaaagagaatatttacaatatatgactaatttgg3840 ggaaaatgaagttttgatttatttgtgtttaaatgctgctgtcagacgattgttcttaga3900 cctcctaaatgccccatattaaaagaactcattcataggaaggtgtttcattttggtgtg3960 caaccctgtcattacgtcaacgcaacgtctaactggacttcccaagataaatggtaccag4020 cgtcctcttaaaagatgccttaatccattccttgaggacagaccttagttgaaatgatag4080 cagaatgtgcttctctctggcagctggccttctgcttctgagttgcacattaatcagatt4140 agcctgattctcttcagtgaattttgataatggcttccagactctttgcgttggagacgc4200 ctgttaggatcttcaagtcccatcatagaaaattgaaacacagagttgttctgctgatag4260 ttttggggatacgtccatctttttaagggattgctttcatctaattctggcaggacctca4320 ccaaaagatccagcctcatacctacatcagacaaaatatcgccgttgttccttctgtact4380 aaagtattgt gttttgcttt ggaaacaccc actcactttg caatagccgt gcaagatgaa 4440 tgcagattac actgatctta tgtgttacaa:aattggagaa agtatttaat aaaacctgtt 4500 aatttttata ctgacaataa aaatgtttct acagatatta atgttaacaa gacaaaataa 4560 atgtcacgca actt 4574 <210>

<211>

<212>
DNA

<213>
Human <400>

gatttctcccggaacctctgctcagcctggtgaaccacacaggccagcgctctgacatgc 60 agaaggtgaccctgggcctgcttgtgttcctggcaggctttcctgtcctggacgccaatg 120 acctagaagataaaaacagtcctttctactatgactggcacagcctccaggttggcgggc 180 tcatctgcgctggggttctgtgcgccatgggcatcatcatcgtcatgagtgcaaaatgca 240 aatgcaagtttggccagaagtccggtcaccatccaggggagactccacctctcatcaccc 300 caggctcagcccaaagctgatgaggacagaccagctgaaattgggtggaggaccgttctc 360 tgtccccaggtcctgtctctgcacagaaacttgaactccaggatggaattcttcctcctc 420 tgctgggactcctttgcatggcagggcctcatctcacctctcgcaagagggtctctttgt 480 tcaattttttttaatctaaaatgattgtgcctctccaaaaaaaaaaaaaaaaaaaaaaaa 540 aaaaaa 546 <210> 21 <211> 2880 <212> DNA
<213> Human <400>

tgctgctctccgcccgcgtccggctcgtggccccctacttcgggcaccatggacacctcc 60 cggctcggtgtgctcctgtccttgcctgtgctgctgcagctggcgaccgggggcagctct 120 cccaggtctggtgtgttgctgaggggctgccccacacactgtcattgcgagcccgacggc 180 aggatgttgctcagggtggactgctccgacctggggctctcggagctgccttccaacctc 240 agcgtcttcacctcctacctagacctcagtatgaacaacatcagtcagctgctcccgaat 300 cccctgcccagtctccgcttcctggaggagttacgtcttgcgggaaacgctctgacatac 360 attcccaagggagcattcactggcctttacagtcttaaagttcttatgctgcagaataat 420 cagctaagac acgtacccac agaagctctg cagaatttgc gaagccttca atccctgcgt 480 ctggatgcta accacatcag ctatgtgccc ccaagctgtt tcagtggcct gcattccctg 540 aggcacctgtggctggatgacaatgcgttaacagaaatccccgtccaggcttttagaagt600 ttatcggcattgcaagccatgaccttggccctgaacaaaatacaccacataccagactat660 gcctttggaaacctctccagcttggtagttctacatctccataacaatagaatccactcc720 ctgggaaagaaatgctttgatgggctccacagcctagagactttagatttaaattacaat780 aaccttgatgaattccccactgcaattaggacactctccaaccttaaagaactaggattt840 catagcaacaatatcaggtcgatacctgagaaagcatttgtaggcaacccttctcttatt900 acaatacatttctatgacaatcccatccaatttgttgggagatctgcttttcaacattta960 cctgaactaagaacactgactctgaatggtgcctcacaaataactgaatttcctgattta1020 actggaactgcaaacctggagagtctgactttaactggagcacagatctcatctcttcct1080 caaaccgtctgcaatcagttacctaatctccaagtgctagatctgtcttacaacctatta1140 gaagatttacccagtttttcagtctgccaaaagcttcagaaaattgacctaagacataat1200 gaaatctacgaaattaaagttgacactttccagcagttgcttagcctccgatcgctgaat1260 ttggcttggaacaaaattgctattattcaccccaatgcattttccactttgccatcccta1320 ataaagctggacctatcgtccaacctcctgtcgtcttttcctataactgggttacatggt1380 ttaactcacttaaaattaacaggaaatcatgccttacagagcttgatatcatctgaaaac1440 tttccagaactcaaggttatagaaatgccttatgcttaccagtgctgtgcatttggagtg1500 tgtgagaatgcctataagatttctaatcaatggaataaaggtgacaacagcagtatggac1560 gaccttcataagaaagatgctggaatgtttcaggctcaagatgaacgtgaccttgaagat1620 ttcctgcttgactttgaggaagacctgaaagcccttcattcagtgcagtgttcaccttcc1680 ccaggccccttcaaaccctgtgaacacctgcttgatggctggctgatcagaattggagtg1740 tggaccatagcagttctggcacttacttgtaatgctttggtgacttcaacagttttcaga1800 tcccctctgtacatttcccccattaaactgttaattggggtcatcgcagcagtgaacatg1860 ctcacgggagtctccagtgccgtgctggctggtgtggatgcgttcacttttggcagcttt1920 gcacgacatggtgcctggtgggagaatggggttggttgccatgtcattggttttttgtcc1980 atttttgcttcagaatcatctgttttcctgcttactctggcagccctggagcgtgggttc2040 tctgtgaaatattctgcaaaatttgaaacgaaagctccattttctagcctgaaagtaatc2100 attttgctctgtgccctgctggccttgaccatggccgcagttcccctgctgggtggcagc2160 aagtatggcgcctcccctctctgcctgcctttgccttttggggagcccagcaccatgggc2220 tacatggtcgctctcatcttgctcaattccctttgcttcctcatgatgaccattgcctac2280 accaagctctactgcaatttggacaagggagacctggagaatatttgggactgctctatg2340 gtaaaacacattgccctgttgctcttcaccaactgcatcctaaactgccctgtggctttc2400 ttgtccttctcctctttaataaaccttacatttatcagtcctgaagtaattaagtttatc2460 cttctggtggtagtcccacttcctgcatgtctcaatccccttctctacatcttgttcaat2520 cctcactttaaggaggatctggtgagcctgagaaagcaaacctacgtctggacaagatca2580 aaacacccaagcttgatgtcaattaactctgatgatgtcgaaaaacagtcctgtgactca2640 actcaagccttggtaacctttaccagctccagcatcacttatgacctgcctcccagttcc2700 gtgccatcaccagcttatccagtgactgagagctgccatctttcctctgtggcatttgtc2760 ccatgtctctaattaatatgtgaaggaaaatgttttcaaaggttgagaacctgaaaatgt2820 gagattgagtatatcagagcagtaattaataagaagagctgaggtgaaactcggtttaaa2880 <210> 22 <211> 5534 <212> DNA
<213> Human <400>

tctcccgggagccactcccatgggcgcctctccagcccctggcctggaagcaccaggaac60 cctggggatggggcagaccctcacagcccggggtctggagccggtgtcggagctcatctg120 ggcccatgacctctccagacatttggcaaaatcaaggcccttagaccagggacagaccca180 agcccaggccctcccagaggtcctaggacgcaaccctttgtgcccttgggctctggaaga240 ggtttgggaagggtttggggtggaagatggcaaagagcagcttggccaggtgaggatgag300 gcagggcagacacaggccagtggggcgtgccatgtgccacagatggagaggaccaggagc360 cagtggcccggcaggcacagcccggttggcgtgggccagagcgcccatcactgacccgtg420 agaactcgactgcccctgccagctctggcactgccccctcccagccgccccgccctagca480 ccctggggggcaccccgcccaaccgtggcctggtccggcccctcccgccctttgctccag540 ttcccgggcttggcacctatagtgggggtgccgcccgcctgccaggctccggggccgggc600 ccacgggagggtggggcggctgggaagctggcacgctgccccgggggagcctctctcggc660 aggcgcccgggtgccgcgggggggagggggaacaaagggctcattctccccgtgcgcagc720 cggtggcatcgccggggcgttggcggaagcccccggggcccgggagggggcaggcccagg780 cgcggccgccgaatcacgggctcctgtttcccgcagggtgctggaggaggaaaccggcgg840 agcagcttccccactctcagttgcgcttctggcgatggcgatcagaggtcctgctgcgct900 ctccgccgcgctctacctccattagccgcgctgcgcggtgctgcgccctcgccggtgcct960 ctctcctggg tcccaggatc ggcccccacc atccaggcac gacccccttc cccggcccct 1020 cggcctttcc cccaactcgg ccatctccga cccggggcgc gtgttccccc cggcccggcg 1080 ccttctctcc ctccgggggc acccgctccc tagccccggc ccggccctcc ccgcggcgca 1140 gcacggagtc tcggcgtccc atggcgcaac ctacggcctc ggcccagaag ctggtgcggc 1200 cgatccgcgc cgtgtgccgc atcctgcaga tcccggagtc cgacccctcc aacctgcggc 1260 cctagagcgc ccccgccgcc ccgggggaag gagagcgcga gcgcgctgag cagacagagc 1320 gggagaacgc gtcctcgccc gccggccggg aggccccgga gctggcccat ggggagcagg 1380 cgcccggtgc cggccacgac gaccgccacc gcccgcgccg cgaccggccg gtgaagccca 1440 gggacccccc tctgggagag ccccatgagg gcaggagagt gatggagagt acgcccagct 1500 tcctgaaggg caccccaacc tgggagaaga cggccccaga gaacggcatc gtgagacagg 1560 agcccggcag cccgcctcga gatggactgc accatgggcc gctgtgcctg ggagagcctg 1620 ctcccttttg gaggggcgtc ctgagcaccc cagactcctg gcttccccct ggcttccccc 1680 agggccccaa ggacatgctc ccacttgtgg agggcgaggg cccccagaat ggggagagga 1740 aggtcaactg gctgggcagc aaagagggac tgcgctggaa ggaggccatg cttacccatc 1800 cgctggcatt ctgcgggcca gcgtgcccac ctcgctgtgg ccccctgatg cctgagcata 1860 gtggtggcca tctcaagagt gaccctgtgg ccttccggcc ctggcactgc cctttccttc 1920 tggagaccaa gatcctggag cgagctccct tctgggtgcc cacctgcttg ccaccctacc 1980 tagtgtctgg cctgccccca gagcatccat gtgactggcc cctgaccccg cacccctggg 2040 tatactccgg gggccagccc aaagtgccct ctgccttcag cttaggcagc aagggctttt 2100 actacaagga tccgagcatt cccaggttgg caaaggagcc cttggcagct gcggaacctg 2160 ggttgtttgg cttaaactct ggtgggcacc tgcagagagc cggggaggcc gaacgccctt 2220 cactgcacca gagggatgga gagatgggag ctggccggca gcagaatcct tgcccgctct 2280 tcctggggca gccagacact gtgccctgga cctcctggcc cgcttgtccc ccaggccttg 2340 ttcatactct tggcaacgtc tgggctgggc caggcgatgg gaaccttggg taccagctgg 2400 ggccaccagc aacaccaagg tgcccctctc ctgagccgcc tgtcacccag cggggctgct 2460 gttcatccta cccacccact aaaggtgggg gtcttggccc ttgtgggaag tgccaggagg 2520 gcctggaggg gggtgccagt ggagccagcg aacccagcga ggaagtgaac aaggcctctg 2580 gccccagggc ctgtcccccc agccaccaca ccaagctgaa gaagacatgg ctcacacggc 2640 actcggagca gtttgaatgt ccacgcggct gccctgaggt cgaggagagg ccggttgctc 2700 ggctccgggc cctcaaaagg gcaggcagcc ccgaggtcca gggagcaatg ggcagtccag 2760 cccccaagcg gccaccggac ccttttccag gcactgcaga acagggggct gggggttggc 2820 aggaggtgcgggacacatcgatagggaacaaggatgtggactcgggacagcatgatgagc2880 agaaaggaccccaagatggccaggccagtctccaggacccgggacttcaggacataccat2940 gcctggctctccctgcaaaactggctcaatgccaaagttgtgcccaggcagctggagagg3000 gaggagggcacgcctgccactctcagcaagtgcggagatcgcctctgggaggggagctgc3060 agcaggaggaagacacagccaccaactccagctctgaggaaggcccagggtccggccctg3120 acagccggctcagcacaggcctcgccaagcacctgctcagtggtttgggggaccgactgt3180 gccgcctgctgcggagggagcgggaggccctggcttgggcccagcgggaaggccaagggc3240 cagccgtgacagaggacagcccaggcattccacgctgctgcagccgttgccaccatggac3300 tcttcaacacccactggcgatgtccccgctgcagccaccggctgtgtgtggcctgtggtc3360 gtgtggcaggcactgggcgggccagggagaaagcaggctttcaggagcagtccgcggagg3420 agtgcacgcaggaggccgggcacgctgcctgttccctgatgctgacccagtttgtctcca3480 gccaggctttggcagagctgagcactgcaatgcaccaggtctgggtcaagtttgatatcc3540 gggggcactgcccctgccaagctgatgcccgggtatgggcccccggggatgcaggccagc3600 agaaggaatcaacacagaaaacgcccccaactccacaaccttcctgcaatggcgacaccc3660 acaggaccaa gagcatcaaa gaggagaccc ccgattccgc tgagacccca gcagaggacc 3720 gtgctggccg agggcccctg ccttgtcctt ctctctgcga actgctggct tctaccgcgg 3780 tcaaactctg cttgggccat gagcgaatac acatggcctt cgcccccgtc actccggccc 3840 tgcccagtgatgaccgcatcaccaacatcctggacagcattatcgcacaggtggtggaac3900 ggaagatccaggagaaagccctggggccggggcttcgagctggcccgggtctgcgcaagg3960 gcctgggcctgcccctctctccagtgcggccccggctgcctcccccaggggctttgctgt4020 ggctgcaggagccccagccttgccctcggcgtggcttccacctcttccaggagcactgga4080 ggcagggccagcctgtgttggtgtcagggatccaaaggacattgcagggcaacctgtggg4140 ggacagaagctcttggggcacttggaggccaggtgcaggcgctgagccccctcggacctc4200 cccagcccagcagcctgggcagcacaacattctgggagggcttctcctggcctgagcttc4260 gcccaaagtcagacgagggctctgtcctcctgctgcaccgagctttgggggatgaggaca4320 ccagcagggtggagaacctagctgccagtctgccacttccggagtactgcgccctccatg4380 gaaaactcaacctggcttcctacctcccaccgggccttgccctgcgtccactggagcccc4440 agctctgggcagcctatggtgtgagcccgcaccggggacacctggggaccaagaacctct4500 gtgtggaggtggccgacctggtcagcatcctggtgcatgccgacacaccactgcctgcct4560 ggcaccgggcacagaaagacttcctttcaggcctggacggggaggggctctggtctccgg4620 gcagccaggtcagcactgtgtggcacgtgttccgggcacaggacgcccagcgcatccgcc4680 gctttctccagatggtgcagggcctggtgagcacagtcagcgtcactcagcacttcctct4740 cccctgagacctctgccctctctgctcagctctgccaccagggacccagccttccccctg4800 actgccacctgctttatgcccagatggactgggctgtgttccaagcagtgaaggtggccg4860 tggggacattacaggaggccaaatagagggatgctaggtgtctgggatcggggtggggac4920 aggtagaccaggtgctcagcccaggcacaacttcagcaggggatggcgctaggggacttg4980 gggatttctggtcaaccccacaagcaccactctgggcacaagcagggcactctgttcccc5040 tcccccttaagccaacaaccacagtgccaccaagctcacacctgtccttctcaggctggc5100 atctcccccaccctgtgccccttttcatggtaccaggcccgcactgggggcaattgactt5160 cctccaatccccactcctccgagacccaggagacaaacagcccttccttggggaaacttg5220 ggaatcattctggcttaaacaacacctcctcctgctgctcactcccgctgagcccactct5280 actgccccagctccgtttctaccaccgcatcctcactgggctcactgcaggcatgctgaa5340 caaggggcctccaaccttctgccctcctgccaaaagatctggggagtgtgaggagagggt5400 ggcatcaggagctgctcaggcttggcggagggagcggcatgggcgatgtcactcagccce5460 ttcccggtccgcccgcttccctccttcatgatttccattaaagtctgttgttttgtgaaa5520 aaaaaaaaaa aaaa 5534 <210> 23 <211> 633 <212> DNA
<213> Human <400> 23 actcttctgg tccccacaga ctcagagaga acccaccatg gtgctgtctc ctgccgacaa 60 gaccaacgtc aaggccgcct ggggtaaggt cggcgcgcac gctggcgagt atggtgcgga 120 ggccctggag aggatgttcc tgtccttccc caccaccaag acctacttcc cgcacttcga 180 cctgagccac ggctctgccc aggttaaggg ccacggcaag aaggtggccg acgcgctgac 240 caacgccgtg gcgcacgtgg acgacatgcc caacgcgctg tccgccctga gcgacctgca 300 cgcgcacaag cttcgggtgg acccggtcaa cttcaagctc ctaagccact gcctgctggt 360 gaccctggcc gcccacctcc ccgccgagtt cacccctgcg gtgcacgcct ccctggacaa 420 gttcctggct tctgtgagca ccgtgctgac ctccaaatac cgttaagctg gagcctcggt 480 ggccatgcttcttgccccttgggcctccccccagcccctc ctccccttcc tgcacccgta540 cccccgtggtctttgaataaagtctgagtgggcggcaaaa aaaaaaaaaa aaaaaaaaaa600 aacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 633 <210> 24 <211> 393 <212> DNA
<213> Human <220>

<22l>feature misc <222>_ (75) .(75) <223>n is a, c, or g, t <220>

<221>feature misc <222>_ (81)..(81) <223>n is a, c, or g, t <220>

<221>feature misc <222>_ (89) .(90) <223>n is a, c, or g, t <220>

<221>feature misc <222>_ (95) . (95) <223>n is a, c, or g, t <220>

<221>misc_feature <222>(167)..(167) <223>n is a, c, or g, t <220>

<221>misc_feature <222>(179)..(179) <223>n is a, c, or g, t <220>

<221>misc_feature <222>(194)..(194) <223>n is a, c, or g, t <220>

<221>feature misc <222>_ (237)..(237) <223>n is a, c, or g, t <220>

<221>misc_feature <222>(249)..(249) <223>n is a, c, or g, t <220>

<221> misc_feature <222> (276)..(276) <223> n is a, c, g, or t <220>

<221> misc_feature <222> (285)..(285) <223> n is a, c, g, or t <220>

<221> misc_feature <222> (295)..(295) <223> n is a, c, g, or t <220>

<22l> misc_feature <222> (312)..(312) <223> n is a, c, g, or t <220>

<221> misc_feature <222> (358)..(358) <223> n is a, c, g, or t <220>

<221> misc_feature <222> (370)..(370) <223> n is a, or t c, g, <220>

<221> misc_feature <222> (377)..(377) <223> n is a, or t c, g, <400> 24 tttttttttt tgccgcccactcagactttattcaaagacc aggaagggcc ggtgcaagga60 ggggaggagg gcccnttgganggccagcnnggaanggaac ggctaccgag gctccagctt120 aacggtattt ggaggtcagcacggtgctcacagaagccag gaacttntcc agggaggcnt180 gcaccgcagg ggtngaactcggcggggaggtgggcggcca gggtcaccag caggcantgg240 cttaggagnt tgaagttgaccgggtccacccgaagntttt gcgcntgcag gtcgntcagg300 gcggacagcg cntttgggcatttcgtccacgttgcgccac ggcttttggg tcagcgcntc360 ggccaccttn tttgccntggccctttaacctgg 393 <210> 25 <211> 3726 <212> DNA

<213> Human <400> 25 cagcgctgct ccccgggcgc tcctccccgg gcgctcctcc ccaggcctcc cgggcgcttg 60 gatcccggcc atctccgcac ccttcaagtg ggtgtgggtg atttcctggc ggggggagca 120 gccaggtgagcccaagatgctgctgcgctcgaagcctgcgctgccgccgccgctgatgct180 gctgctcctggggccgctgggtcccctctcccctggcgccctgccccgacctgcgcaagc240 acaggacgtcgtggacctggacttcttcacccaggagccgctgcacctggtgagcccctc300 gttcctgtccgtcaccattgacgccaacctggccacggacccgcggttcctcatcctcct360 gggttctccaaagcttcgtaccttggccagaggcttgtctcctgcgtacctgaggtttgg420 tggcaccaagacagacttcctaattttcgatcccaagaaggaatcaacctttgaagagag480 aagttactggcaatctcaagtcaaccaggatatttgcaaatatggatccatccctcctga540 tgtggaggagaagttacggttggaatggccctaccaggagcaattgctactccgagaaca600 ctaccagaaaaagttcaagaacagcacctactcaagaagctctgtagatgtgctatacac660 ttttgcaaactgctcaggactggacttgatctttggcctaaatgcgttattaagaacagc720 agatttgcagtggaacagttctaatgctcagttgctcctggactactgctcttccaaggg780 gtataacatttcttgggaactaggcaatgaacctaacagtttccttaagaaggctgatat840 tttcatcaatgggtcgcagttaggagaagattttattcaattgcataaacttctaagaaa900 gtccaccttcaaaaatgcaaaactctatggtcctgatgttggtcagcctcgaagaaagac960 ggctaagatgctgaagagcttcctgaaggctggtggagaagtgattgattcagttacatg1020 gcatcactactatttgaatggacggactgctaccagggaagattttctaaaccctgatgt1080 attggacatttttatttcatctgtgcaaaaagttttccaggtggttgagagcaccaggcc1140 tggcaagaaggtctggttaggagaaacaagctctgcatatggaggcggagcgcccttgct1200 atccgacacctttgcagctggctttatgtggctggataaattgggcctgtcagcccgaat1260 gggaatagaagtggtgatgaggcaagtattctttggagcaggaaactaccatttagtgga1320 tgaaaacttcgatcctttacctgattattggctatctcttctgttcaagaaattggtggg1380 caccaaggtgttaatggcaagcgtgcaaggttcaaagagaaggaagcttcgagtatacct1440 tcattgcacaaacactgacaatccaaggtataaagaaggagatttaactctgtatgccat1500 aaacctccataatgtcaccaagtacttgcggttaccctatcctttttctaacaagcaagt1560 ggataaataccttctaagacctttgggacctcatggattactttccaaatctgtccaact1620 caatggtcta actctaaaga tggtggatga tcaaaccttg ccacctttaa tggaaaaacc 1680 tctccggcca ggaagttcac tgggcttgcc agctttctca tatagttttt ttgtgataag 1740 aaatgccaaa gttgctgctt gcatctgaaa ataaaatata ctagtcctga cactgaattt 1800 ttcaagtata ctaagagtaa agcaactcaa gttataggaa aggaagcaga taccttgcaa 1860 agcaactagt gggtgcttga gagacactgg gacactgtca gtgctagatt tagcacagta 1920 ttttgatctc gctaggtaga acactgctaa taataatagc taataatacc ttgttccaaa 1980 tactgcttagcattttgcatgttttacttttatctaaagttttgttttgttttattattt2040 atttatttatttattttgtgacggagagagattccatctcaaaaaaacaagttattaaaa2100 atgtatatgaatgctcctaatatggtcaggaagcaaggaagcgaaggatatattatgagt2160 tttaagaaggtgcttagctgtatatttatctttcaaaatgtattagaagattttagaatt2220 ctttccttcatgtgccatctctacaggcacccatcagaaaaagcatactgccgttaccgt2280 gaaactggttgtaaaagagaaactatctatttgcaccttaaaagacagctagattttgct2340 gattttcttctttcggttttctttgtcagcaataatatgtgagaggacagattgttagat2400 atgatagtataaaaaatggttaatgacaattcagaggcgaggagattctgtaaacttaaa2460 attactataaatgaaattgatttgtcaagaggataaattttagaaaacacccaatacctt2520 ataactgtctgttaatgcttgctttttctctacctttcttccttgtttcagttgggaagc2580 ttttggctgc aagtaacaga aactcctaat tcaaatggct taagcaataa ggaaatgtat 2640 attcccacat aactagacgt tcaaacaggc caggctccag cacttcagta cgtcaccagg 2700 ggatctgggttcttcccagctctctgctctgccatctttagcgctggcttcattctcaga2760 ctctggtagcatgatggctgtagctgtttcatgggccccttcaaacctcatagcaaccag2820 aggaagaaaatgagccattttttgagtctccttcatagacttgaataactctttttcaga2880 gcttctcacagcaaacctctcctcatgtctcctcatgtcttattgttcagaaatgggtaa2940 tgtggccatttcaccagtcactgccaacaacaacgaggttcctataattgtctctgagta3000 accctttggaatggagagggtgttggtcagtctacaaactgaacactgcagttctgcgct3060 ttttaccagtgaaaaaatgtaattattttcccctcttaaggattaatattcttcaaatgt3120 atgcctgttatggatatagtatctttaaaattttttattttaatagctttaggggtacac3180 actttttgcttacaggggtgaattgtgtagtggtgaagactcggcttttaatgtacttgt3240 cacctgagtgatgtacattgtacccaataggtaatttttcatccattaccctccttccgc3300 cctcttcccttctgagtctccaacatcccttataccactgtgtatgttcttgtgtaccta3360 cagctaagcttccacttataagtgagaacatgcagtatttggttttccattcctgagtta3420 cttcccttaggataacagcccccagttccgtccaagttgctgcaaaatacattattcttc3480 tttatggctgagtaatagtccatggtacatatataccacattttctttatccacttatca3540 gttgatggacacttaggttaattccattcaatttcattcaatttaagtatatttgtaagg3600 agctaaagctgaaaattaaattttagatctttcaatactcttaaattttatatgtaagtg3660 gtttttatat tttcacattt gaaataaagt aatttttata accttgaaaa aaaaaaaaaa 3720 aaaaaa 3726 <210> 26 <211> 127145 <212> DNA
<213> Human <400>

gatcacaggtgtgagacaccacacccagccagaaattgaaccttggtgagagacactgag60 tggggaagggcagagactgggagttaggagttacagcatctgaaggccacatcctggaga120 gatggccacagactcagccagtgaagaggaagtgctggggctggggccagaaccctgtct180 gtgtgacccctgagactgagctcagacacccctaaccctgaaggcacctctctttcagga240 ccaacagccaaaggcacagaagccactggcctgggagggactgtccctgggaatgaccct300 gctctctgagggctgggcatctggactccctctgctccagctcctctgtggttgtattcc360 tccatttctattctaattagtcagtttccatggctggataccataaaatctcagtagaag420 gaagaacaggccaaccatcagagctgttcaatttcagaaaatctctttttgttgctgggg480 acagagtctcactatgtcacccaggctggagtgcagtggcgcgatctcagctcactgaaa540 cctctgcctcccgggttcaagcgattctcctgcctcagcctcctgagtagctgggattgc600 aggtgcatgccaccttgcctggctaatttttgtatttttagtagagatggggtttcacca660 tgttggccaggctggtctcaaactcctaacctcaggtgatccacccacctcagtctccca720 aagtgtttggattacaggcgtcggccaccgcgcctggcccagaaaatctctttagtcggg780 acttgagaaagggactgggttccatctggtgggaatgggagggaggttcagtgtctgctg840 ccagtgagacctgggtttgttccctcccccctggctgtgtgatggaggcaagacccttca900 ttctttgagcctcagtgtcctgtctgtgaaacaggcaatgagcacatttatctcacaggg960 tcccggtgaggcacattgggataacataggtgaagcccttaacacagttctgggcaaagc1020 aatgtgacttctctcctccccagcggcacttgcaccacgtggggagaaactaggttaata1080 catccctgccacacataactaccaagtgcctgctgtgtgctggccacaacactaagagcc1140 ttacatgtggtccttcatttaattttcaaagtgatgacgatgattctcagtgcacagatg1200 gagactctga gcccagagag gctaaataaa ctgctctcaa ggacaccagc actttctgca 1260 aagagcccca gatcctaact aggacttacg ttgcctgcgc tgggaagaga cccaaatgcc 1320 tcccggctgt aggagtccct gattgcagac gtagggtctc agtccccgcc ccaagaagct 1380 gtaggtccag ttgaagaaga gacacacaca aggaaaagga aattgaactg agaaggcaaa 1440 gcgtgactgt ggggcctctg ctatatccag ggtctccaga gaaaggacta gaagccacta 1500 ttccaattct gaggcctcag ggaagcagca agttcctgtg aggaaacagg atcccacagg 1560 tttcatcctc ctcctgtcac tcttctaggt ggggagggag ggctccccca cgtcccacat 1620 aagcacacagaaaggagaggccagggcagcacaggctcagaacctgaaggacttggggac1680 atcgccagccccatatccttgttttatacaccaggtagggcaggaactatggcaggtcca1740 cagaaaggggccggcagaagcacagccacgacgcaggccccctgggctgtccagtttctc1800 ccggacagaacatttcccttccctagcagcccccaacgtggagcactggatttggagtca1860 ggagacctgtgtcttctgcaatcactctgagaccaactcctgtgtaatcgtgagtgagcg1920 ccttcccatctctgggcctcagcttccacctctctaaaatgagggggttggattccatcc1980 aatgttataagagccaaaggttatgagttggtagcgcccccaccattccgggtttctcca2040 atctctccaggggcctcagagaccccagacagaagaggaacttggacagaggcttgggtg2100 ggggtggaggtggggattctgagccgtggatccaccctctgctgagtgccaggcctacag2160 gcaggcaggcagagcaggcaagagccgtcccctacacaaagggaattggcccctcatggt2220 gggacagaggccagaacccagctgggccctcaaccacccttctttcctccacaaccccct2280 cccagggatggtggcatccgaagccagcctggcaagggaactggttgccacgtggggact2340 tcccggagctgggggtgatgggaaacagggtgacgggaaacgtcctgaggttgcttcctc2400 cccttttgtttggatctcagactgacctgggaaccaactgggcagccatggggtattctg2460 atggtggggagttggagggggagaagggacctgccccatcccctcaggctgctttgcaag2520 ttaaaatagctgtgaagatctatctcccagaattctaaaagctaaaataccttttgaacc2580 accaccagaccattatgcctggagtggaaggatgcttagaggaatcccttcttttttttg2640 agatgaagtctcgctccatcacccaggctggagtgcagtggcgctatctcggctcactgc2700 aacctccacttcccagggttcaagcaattctcctgctttagcctctcgattagctgggat2760 tacaggcgtgcaccaccacgcccggctaatttttctattttttagaagagacgagggttc2820 accatgttggccaggctggtctcgaactcatgaactcaaatgatccacccgcctcggcct2880 cccaacacgctgggattacaggcgtgagccactgtgcccatctcgaatccctttttaaaa2940 cttcaggtatggctgggtgcggcggctcatgtctgtaatcccagcactatgggaggctga3000 gtcgtgaagatcatttgagcccaggagttcaagaccagcctgggcaacataggagaactc3060 gtctctattcaaaaaaataccaaaaaccaaaaaccaaaaaattgtaagtcatgacccact3120 ggtggatcttgaaattaattaagtcggtactctgagtaaatcagaatttttttttgagat3180 ggagtctcac tctgtcaccc aggctggagt gcagtggtgt gatcttggct cactgcaacc 3240 tccacctcct gggatcaagc aattctcctg cctcagcctc ccaagtaact gtgactacag 3300 gtgtactccg ccatgcctgg ctaatatttt gtattttagt acagacgggg tttcaccatg 3360 ttgcccaggc tggtcttgaa ctcctgagct ctggcaatct gcccacttcg gcctcccaaa 3420 ctgctgggat tataggcgtg agccaccgtg cctggccgca aataaggatt taataatgac 3480 gatgataaaa tagaagggaa aatctcagag cacatcctgg gtagtaatag caaactgtct 3540 tggctgtgtg gtggctcatg cctctaatcc cagcatttta ggaggccaag gcaggaggac 3600 tgcttgaggc taggagttaa aatcagccta ggcaacacag tgaggcccca ttcctacaaa 3660 aaaaaaaaaa aaaagaaaga aagaaaaaat tagccgggta tggtggtgtg tgcctatagt 3720 cctagctact ccagaggctg aggcgggagg attgcttgcg cccaggagtt caaggctgca 3780 gtgagccatg atcgtgccat ggtacggcag cctgggtgac agagcaaggc cccaactctg 3840 aaaaacaaaa taaatacaat aaaataaaat ggtcaaaatg gcctggtgca gtggctggtg 3900 cctgcaacca gagctacttg agaggctgag gcaggagaat cactggagcc caggaggttg 3960 aggcaccact gaactccagc ctgggtgaga gtgagatcct gtctctttaa aaaagaaaaa 4020 acaaaaaaag caaactgtct catgaaactc ttgtttccat gttgcacgct ctgccaggtt 4080 gtgatgtaat gtatttctta ctctgggtca cagtcacaaa accttgaaat gtcactcact 4140 gtcttggctc atgcgtcgta agcctttgtt ccccaacagg gggaagtgaa ccagcacaca 4200 aggcccttcc gtcctgcgga gctcactgcc ttcctcagct cctggcccgc acttccgacc 4260 acacactggg gacacaccct cgggggggcc ccaccccagc agctgcccat gttcacacct 4320 cttcagttat ttcaaactcc gcctctctcg gcctgatgcc caacacttcc ttcacccaag 4380 gaggtcctgt tcaaatatca cttctggcca ggcgcggtgg ctcaggtcta taatcccagc 4440 acttcgggag gccccgaggc aggcagatca cctgaggtca ggagtttgag accagcctgg 4500 ccaacaggtg aaaccccgtc tctactaaaa atacaaaaat tagccaggtg tggtggcacg 4560 tgcctgtagt cccagctact caggaggctg aagcaggaga attgcttgaa cctgggaagc 4620 ggaggttgca gtgagccaag attgagccat tgcactgcgg cgtgggaggc agaggtagac 4680 tctgtctcaa aaaaaaaaaa agtcactttc tctgccagtc atatcttctg caaccctgag 4740 gagccaggca ggacgacccc tttaccctct gaatcaattg gtctgtatca gggtctggca 4800 gagggagggg aagttggccc ctctgattta atggatgaat caagaaaatg tgtgactgag 4860 ccatggattc atggggatgg ggtcctggag cagaggcttg ctgtgcacct actaggtgct 4920 gtgtacctca caagccactg gggacatcag accaccagaa taagtccact ttccccaagg 4980 aaagtggtcaaatgtgggagccaggtgtgcaaatccccaccccagggtgataacagcccc5040 aataaaggcacatgcaagggggaccttcggagctgatgacactgtacaggcatctaagag5100 gctggtgacagggtcaccaagcagaggtctagagcagggctgagtggggtagggggggtt5160 cttccaggcaaaaggcaaaaactctgttggtaccgtgtaggtcttccacagcacatgcca5220 catgagaagaaacattcgcctggcgagtggctgaagtctataatcccagcactttgggag5280 gctgaggcaggtggatcgcttgagccaaagagtttgagatcagcctgggcaacatggcaa5340 aaccccgtctctacaaaaaatacaaaaattagccaggtgtggtaacccatgcctgtggtc5400 ccagctactcgggaggctgaggtgggaggattgcttaagcctaggaggtcaaggctgcag5460 tgagccatgattgtgccaccacactccagcctcagtgacagagtgagaccctgtctcgaa5520 aaaaaaaaaaaaaaaagagagggaaaggaaaaattttattttacatttatgtattgaggg5580 cagggaccatgcctgctgggctgctcaccactgctgagcaggattcctggtgtggcatcc5640 taacacaataaatatttactgaatgtgtactcaggaaactgcaaagggttcaggctggcc5700 tgagagtaaagtgaaagaaggaagtggtagaagagcccagaggtctgtgaccccagaacc5760 tggagggcacctgtggcctgggtctttctcctgcaggcactggggaaaagtcggagggtt5820 tattttatttaattaacttatttattaatcaattaattttttgagatggagtctcactct5880 gtcacccaagctggagtgcagtggtgcgatctcagctcactgcaacctctgcccaccggg5940 ttcaagcgattttcctgcctcccgagtagctgggattacaggcattcgccaccatgcccg6000 gctaatttttgtatttttagtagagatggggtttcaccaggctggccaagctggtctcga6060 actcctgacctcaagtgatcctcctgcctcggcctcccaaagtcctgggattacaggtgt6120 gagccaccgcgccaggccggtaggagggtttaaacaggaaagagataagcagtcagattc6180 atagtttagaaaatcctcaggttctggtgttcgggtggatgcctggagtggggatctgga6240 aatcaggggcaggggttagtaataacccaggtgaggagacttgagtctagaggcagccaa6300 gtggggacctatggaggagttcacgtgctgcaggtgtgcgccgccgaggcggagccaggc6360 tctggagctgccaggggctcagaagcctccctctcagatctctccccttttggccacaga6420 tgggaaggagagaggcactcacccgacccagcgtggcagtacagtagtgtccaacctgtc6480 actgttgggcgtggtggcgtgtacctgtagtcccagctactgaggaggctgagatggcag6540 cagcacttgagcccaggagttggaggctgcagtgagccgacagcgccactgaactctagc6600 ctgggtgacagagcgagaccctgtctctaaaaaacagaaaagaaaaattacaggtcgggc6660 gcagtggctcacgcctgtaatcccagcactttgggaggccgaggagggtggatcacgagg6720 tcaggagttc aagaccagcc tggccaatat ggcgaaaccc cgtctctact aaaaatacaa 6780 aaattagcca ggcgtggtgg tgtgcgcctg tagtttcagc tacttgggag gctgaggcag 6840 gagaatagct tgaacccggg aggcggaggt tgcagtgagc cgagatcacg ccactgcact 6900 ccagcctggc aacagagcga gactctgtct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 6960 aaaaagaagaaaaagaaaaaagagaaagaaggaaagaattacataacagtaagcaaccta7020 gctagatttgaaccaggccctgcagttctaaagcactggcttttgcggagcggcactcac7080 tccgcatcgtggcataggtagatttcttttctaaaggtgaggtcagtgctgggcacttag7140 caggcgcccggtgggctgcgccgtcctggaggaaggctgattcctcccaccccgactcct7200 ggctcgtgggtgggtaatccagcacattctccccaccccggcaaccaactttgtggccga7260 acaagccctccccggcttgttccgctggtcccaggcgcctgcgcatccggacacgatgag7320 gagcaggtgcgcggggccggggtgtgttcgagggggtcgtgcgcgcctgggctgcctccc7380 cgcggacggcggactgggccggggcggcgcttcctggcagagaggcgcggaggggcgtgg7440 ctttggagaggtgcccccggcgggctggcggcctggctgcggtgaaaggcgggcggacgc7500 aggtgacgacaaccgctccataaagggcgccgcggcgcgacgctcgccttatatgggcag7560 gctcggcgcgggaggggcggggcgttccacccagctggctccgcaccgaggcccggccga7620 acccccgaggggggaaacttctctgcgagggtggagcctcctcagcggcgtccccaggtc7680 ccgagaggggtccctacccaggctaagactcacgacgggctccaccctgcaggggctcaa7740 cttgcagaaaccctggggcctgccttccccaggggtctgccctcctcaggccctgctagg7800 gcactgactcggtttgtgctgtgtggcgttttttccttcaccccacctgggccgcaggtc7860 ctcgctagatagccgagggagggtcctttaagtgagctcacctcggagcccccagataac7920 caagcctgagcctcccggctacatggcgaggcttccccaatccggtcagccccaagcagg7980 tgcctttctctaactggcacaaaggaagtctcctagccaggctgagcccaagcctcggta8040 aacatgagccttggatccactggaagtgtttggctaactgggcccttcttggccagacaa8100 gactttaaccctaagaggaagctgccagcatgacgcagcccaccatattctccctccaag8160 ctctcttcatagcccgggtccttaaaaacccaaatctgtccaattgctacttgccgtcca8220 ctcgttgacagttactccgcttcacagcctcccgatcacctgagtgtcctccctcggctc8280 agtgcacagg gctctgtgag cttacagttc cctggttgcc gttccgtgcc tcccagccct 8340 gcacctgctg ctcctttctg gaaagccctt tccttgcaca ctcccagaca cgtgctcacc 8400 cttcagagag atacttctta gcgtcttctt cctgacattt gtagtgatta cttaaccttt 8460 ctgagcatca atttcttcat ctgcaagatg ggggtaaaat aatccccacc tcactgtgtt 8520 attgtgagga tcgaatgagt taatgtttgt aaaatgcctg gcatatagta gctgctcatg 8580 aaaaactcgt tgaccaaatt cctcttcctg tgctctaatt gctcatgtat gtgttgtgag 8640 tgccatgaag gctggcctct tccttttcca gctatgcata cctagttcct ggcacatata 8700 tagatcttga accagtgttt gttggcgaat gaatgaattt caggcagtag gggtcgggga 8760 gagaagagac ccctaactgt gatggtcatc aaccctcaca tctgccggga tgtagggcat 8820 tctaatgctt cccccctcag ttgcccagag cttcatggca accaggaggg acacagcatg 8880 gatatggacc ccgttttcca gataaaccta tgagtgatta gaggtgaagt aacttcccca 8940 cggttacaca atgagtggaa gagtcggcat cagggtgacc aacgtgtact tttttttttt 9000 ttttttgaga cggagatttg ctcttgtcgc ccaggctgga gtgcaatggc gcgatctcgg 9060 ctcactgcga cctctacctc ccaggttcaa gcaattctcc tgcctcagcc tcccaagtag 9120 ttgggattac agttgcccac acgcccagct aattttgtat ttttagtaga gatggggttt 9180 cttcatgttg gtcaggctgg actcaaactc ccaacctcgg gtgatctgcc cgcctcagcc 9240 tcccaaagtg ctgggattac aggcgtgagc cactgtgccc ggcccaatgt gtattattat 9300 tattattatt attttagcac tgagagttcc acgtcccagg aatctcttta gtctcaggca 9360 gccaggatgg ttggtcaccc aagatcaact tctaaacgtt agtctctgag gaccgccacc 9420 ttccaacctc ccctgcaccc gtcccattat tcccaagtat tttactgcgt tcctgaaggg 9480 gacacaggct ctccagccca gaaggtccaa cagattttaa aaagtcacac tctgattccc 9540 caaaaaagtt agactcacag cacagtaggg atgggggaca aggacattgg aagggcattg 9600 aggccaggtg tggtggctca cgcctgtaat cccagcactt tgggaggctg aggcgggtgg 9660 atcacttgag gtcaggagtt cgagaccagc ctggccaaca tggtgaaacc ccgtctctac 9720 taaaagtaca aaaacaagcc aggtgtggtg gtgcgcacct gtagtcccag ctactcggga 9780 ggctgaggca ggagaatcgc ttgaacccgg gaggcaaatg ttgcagtgag ctgagatcgt 9840 gccactgcac tccagcctgg gcgacagagt gagactctgt ctcaaaaaag aaaaaaaaga 9900 aggcccaggt aggagtttgc ttcactttga cagggactca tgggccactc ctgcaccagg 9960 ccctgggcct gggaccagga actgagagaa ggctggcccc cacctgtggg actctagcca 10020 ggtgggggag acagatgtat agacacaatg ccaacagttt ggttcctcga cggctggaga 10080 agggagtgat cgaccagggt ttctgaagaa ccccctcctg acgtggccac tcaccagctg 10140 acctcaggcc tgtcccttcc tttggctggc cctggacctt ctctgtcaac tcaggcagtt 10200 ggagctggtc cctgagggcc ttcctgccct gaagtcatga cttgtgggga gctgagttct 10260 gggaaatgca tcctctggag aggcaccaga ggccgcgcat gcctgagtga gtgtgggggt 10320 gcgccctggc ctcactagcc aaacaccaac ttcatcttcc caggctaccc tggcccgagc 10380 agctccggct ccttccctgc ctgcctcatc ctcccaggcc actgtccagg aagctggcct 10440 ctctgcctgt tccccacagc ccctgggggt ggggccagag tagggcaaaa agggcctggg 10500 cctggcccag cagagcctct gcccctcctt cgggggctcc tgttcttgtg ggctgagagc 10560 tgcagccctg cagccggcct ggctgtggct cagtggtcag ggccaagtgc agagcaaaca 10620 ccctgcccac tgggcagcca tttcacggtc attcccaggc tgcatggggt ccccagtcgg 10680 gcaactaagt gcagatgtga aacaacgagc tttccaagat ccagggattt gacccttggg 10740 aaagagactc cctaagggaa ctgcttcctg tcactcccca accaccactt tgagaaataa 10800 ttttctctcc ctcaacctca ctgccagcct cagtcaagag caaaccgagg actggtagtg 10860 ggagctcagg gccaccttgg gattctctgc tctcgctgct ggctgagccc aggcaaggcc 10920 cctgccctct ctgggcttcc atttccctct cctgctccaa acttgctagc ttccttccct 10980 atctcaacat catagggacc cttcgagatg ggaactacta ataggggaaa tcatatggga 11040 aaccaggctg ggcgcagtgg ctcacaccta taatcccagt actttgggag gccgaggtgg 11100 gaggatcacc tgaggtcagg agttccagac cagcctgacc aacatggtga aaccctgtgt 11160 ctactaaaaa tacaaaaatt agccgggcgt ggtggcaggt gcctgtaatc ccagctactc 11220 aggaggctga gaggtagggg aatcacatga acctgggagg tggaggttgc agtgagctga 11280 gatcctgcca ctgcactcca gcctgggtaa cagagtgaga ctccatctca aaaataaaat 11340 aaaaaatgac catatcctta taggaaccat tattttgaac tcagaatctc agaaaaacca 11400 ggatttgggg cctggaactt tctttgtctt attttgtttt gttttggatt ttttggggag 11460 acagagtctt gctctgtcac ccaggctgga gtacagtggc gcgatctagg cttactgcaa 11520 gctccgcctc ccgggttcac gccattctcc tgcctcagcc tcccgccacc acgcctggct 11580 aattttttgt atttttagta gagatggggt ttcaccgtgt tagccaggat ggtctccatc 11640 tcctgacctc gtgatctgct cacctcggcc tcccaaagtg ctgggattac aggcgtgagc 11700 caccgtgcct ggctggggcc cggaactttc taaggcagag gcggcagaga caaagaggtg 11760 gctggaggtg gggcagtgcc gagccaagtc tcaggacatc cctactgccg agcctcccct 11820 cccacaaagt aaaccggcag gtgggcagtg caggcggggc ccagctcggg tttcactcct 11880 tCCCCgCt Ct cggggacaat aaaatgctcc ctttgccctg gaaatcccac ttgtataaaa 11940 tccaaaagaa gaaataagct cttatgttca aacaggtttg ttccaacctc atttataatg 12000 gaaaaatatt aactgaaaaa ttccttagta tccgacaatg ggggagaagt taacagtttg 12060 accggagctg agtgaeatgc aaaagggtgt ttgtggagtg cagggagctc ctgctgtgtg 12120 tgtgggaggg tggagagggc atggggagag gagcagggac cccagagtca gactgtctag 12180 gtttaaatcc tgtctgctcc ttcctagctg tgtgaccttg agtcataacc caaagccctc 12240 tgtacctcca tgtccccctc cataaactgg cactgggctg ggcatggtgg cttatgcctg 12300 taatcccagc attttgggag accaaggcag gtggatcacc tgaggtcagg agttagagac 12360 cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agccaggtgt 12420 agtggcaggt gcctgtagtc ccagctactc aggaggctga ggcaggagaa tcgcttgaac 12480 ccaggaggca gaggttgcag tgggccgaga ttgtgccact gtgctccagc ctgggtaata 12540 ggtgacagag cgagactccg tctcaaaaca aaacaaaaca aaaaaaagga gagagagact 12600 tgggggatgt gtgtgcccag aggaaaatcc atgtgaggac ccagcaagaa ggtggccacc 12660 cgcaagccaa gcagagaggc ttcaggagaa accaaccctg ccagcacctt gattttggac 12720 ttccagcccc agaactgtga aaaaataaac atctgttgtt taaaccaccc agtctgtgat, 12780 attttgtgat ggctggccta gcaaactaat acacattact aacacacaat aagagaagcg 12840 tttaataggg cgcttaccac gtaattgcat tgtgttctga cattacattt acgatctcat 12900 aaccatgagg agggtcctgt cctcccattt cagagatgaa ggaaactgag gcttggctag 12960 tgacggagag ggctgtgact ggagccagga ctgtgtgact ccaaggcccc accaaagcct 13020 cctcctggga tggaccatgg actttcctgc ctctgtgctg tgcatacgct ctcccttctg 13080 cctggaatac ccttcccacc acttgcctct caggacgagt cccagtcgat tcttcaaaac 13140 tcttcttggc ccggcaaggt ggctcacacc tgtaatccca gcactttgga aggccaaagt 13200 gggtggatca cttgaggtta ggagtttgag accggcctgg ccaacatggt gaaaccctgt 13260 ctctactaaa aatacaaaaa ttagctgggc cttgtggcag gtgcctgcaa tcccagctat 13320 tcaggaggct gaggcaggag aattgcttga acctgggagg tggaggttgc agtgagccaa 13380 gatcacacca ctgcactcca gcctgtgcaa cagagttaga ctgtctcaaa acaaaaacaa 13440 aaaacaactt ttctcaagca tcacctcctt cccatgcttt acccgacaat ctccttttgc 13500 agatgtgctg cttttcaggg cttgcggcca gtctgtactc tgtcaccatg gtggtaaatg 13560 tcatctctcc tgtagcattt agactttaga tgtgtccatg tgtttgctgt gaactcctgg 13620 aaggcagggg ctgtgtcttg ctctagttcc tatcacccag caggcccaga ggggctccgc 13680 acagacgctt gctggctgag gtagccagtt tggcctggag agagtattcc cgcctcagga 13740 gtggatcatg aggaaatgga atctcctgcc tccttgtggg gtgggggttg ggggaggtgg 13800 ataaaagaga ggctccacct ggcacggtgg ctcgtgccca taatcccagc actttgggag 13860 gccgaggtgg gtagatcacc tgaggtcagg attttgagac cagcctggcc aacatggtga 13920 aaccccatct ctactaaaaa tacaaaaatt agctgggcac ctgtaatccc agctactcgg 13980 gaggctgagg ctggacaatc gcttgaatcc aggaggtgga gcttgcagtg agccaagatt 14040 gtgccactgc actccagcct gggggaaaag agcaaaattc catctaaaaa aaaaaaaaag 14100 cggatcaagg tccctactct gggcatgaga ggagggatcc tttgacactc ctgggagcag 14160 cagtgtggca gaggaggagg agcagggcat ggggtcagcc accctcagtc catttcccag 14220 ggtgtggcct taggcacggt cactacctct ctgggcttct gtctccacat gtatgaaatg 14280 gaatcagtcc ctccttccac aggtgttagg tcgaagaagg cacctctggt ggtatcggca 14340 cagaggctgg acactggatg acttctttgc tgggacactg aggtaggggg cagaccagag 14400 acagacagct acttgcctaa gctcacccag caagctggct gaaggtggag aactggcttg 14460 tcctccagtt ggtagttaac agctgtctag caggagtgtt cttgctccca ggagacgctc 14520 cgttggctgc cacagaggta agcgtgagag tgcgctcaga agtggctggg aggcatggag 14580 aacagaggag caggttcagg gtgaattcca gtgggcattc tccaagggtg aggtcactgc 14640 ctccaactcc ctagggctgc ctgagacaca ggcaccacca agccagctcc agagcaggag 14700 gaggtggtgg cagggaccag ggccaggtca cagggctgaa tgtaaggccc tcagcctggt 14760 acagcgacgg gcccctccca tggtgctggg gtccttacct tgggaagccc ggtgtttcct 14820 gtttaagatg tggctggggg taggggaaag gagaaagcca cacagataac acttctggaa 14880 cttccaatcg gtgccagcgt gcttccacct gctgagccgt gacctcattt gcagggactg 14940 tcatgagccc caacttggag atggtgcaac tggggctcaa aatggtgaaa accttgtccc 15000 aaaaggaaag cagtatagct aatgagcaag aacaaagaga atttgaaatt aaagacattg 15060 gggttcattc ttttcccctt ttttaaaatt tatttttggg ccgggcacgg tggctcacgc 15120 ctgtaatccc agcactttgg gacgctgagg tgggcggatc atttgaggtc aggagtttga 15180 gaccagcctg gccaacatgg tgaaaccctg tttctactaa aaatacaaaa attaaccagg 15240 catggtggca aatgcctgta atcccagcta ctcgggaggc tgaggcagga gagctgcttg 15300 aactcaggag gcgaaggagg ttgcagtggg cagagatcat gccattctac tccagcctgg 15360 gcaacagagc aagattccat ctcaaaaaca ataaaataaa taaataaaat ttatttttta 15420 tatttttatt ttttagaaca agatctcact ctgtcaccca ggctggagtg cagtggtgag 15480 atcacagctc actatagcct caaactcctg ggctcaagtg atcctcccac ctcaccctcc 15540 caagtagctg ggactacagg cgcacaccgc catgccaggc taattttttt ttaaattttg 15600 tgtaaagaca gggtcttgct atgttgccca ggttggtccc gaactcctag gctcaaacga 15660 tcctcttgcc ttggcctccc aaagtgctgg gattacaggc gtgagccatc gtgtccggcc 15720 acatcggagt tcaaatctga gctctgaact ccattcatgc caagttactt aagccctcca 15780 agcctcagtt tccttgtctg taaaatggcg gtaacaatgg tccctgctgt tggggttgcg 15840 gtggagactc agtgagagga ttcatgtagc acacactcag taagtgccag ctgtcactgc 15900 cagcctattt caccaccgtg aacacagagc ctcagaatgg aaaagcagcc tgcccaaggt 15960 cgcacaactt gcaggtggca caggcaggat ctgaatccag atcagattct tcccgcccta 16020 cttctatcac cgtggaaggg cctggggggg cctgcagcca ggaggtggct ggaaagggag 16080 gttccttgga acaaccagtg gcccaggctt cctgcagagc cggggacccc agccctggcc 16140 agggtaaggg tcacgcctgc agctggtgtt ccaggcatcg gagaggaact gcggctgcag 16200 gcctggcagc cttaccgtcg ccagcatcct gccctccatg gacacggccc caacattgtt 16260 ttctgggccg ttccctgccc agagcccaca cattcgggat ttccgcagct tggccagcac 16320 taccttcgct tcctggagca gctttcccca ggcggccggg gtgggggttg agctggccct 16380 ggcccctggt aggggcaggc actgctcgga aggcagtggc agcagcgccg tcaacatcct 16440 cttgacctga caggtcctta cccgagttct acctcctcag aaacacagcg gccctcctca 16500 ctcccctctc ctgaggccag cgtagaaaag gccctacctc atttccactt tagggtaggc 16560 tggagtgaga gcccgggtta aaatcctagc cctactacaa aggtgctgtg acctgggcaa 16620 gcctcccctt ccctctgcct cacaagggat gctgggtagc ctgaggtgcc ttaggctgcc 16680 ctgacatcag ctcagggatg accggcgccc cgtgctctga ggtctctggg cataataagc 16740 tccttgatga cagggtcagt ttctctcccg tgttctgcaa gtttattttt attattatta 16800 ttatttttga gatggagtct tgctctgttg cccagactag agtgcaatgg tgtgttctca 16860 tctcaccgca acctctgcct cccaggttca agcgattctc ctgcctcagc ctcccaagta 16920 gctgcgatta caggcgtgca ctgccacgcc cggcaaattt ttgtattttt agtagaaaag 16980 gggtttcgcc atgttggcca ggctggtctc gaactcctga cctcaggtga tccacccgcc 17040 tcggcttccc aaagtcctgg gattacaggc gtgagccacc gcgcccggct ccatgttctg 17100 tatatttaga aggaacctgt gtgagtggcc accaaacgtt cactctgaac catgctggcg 17160 ctgcctgcag gtgagcgtgc ctgcccagag tggtgtctca gttgtctcac tgcccaccct 17220 ggcgctccgt ctcctctgtg ggctggcacc tgctccctgg tagggcggag ctgaggggca 17280 caagggagcg tggaagtcaa gcagccagcc cagcaaactc gagcttccac ccctgccgcc 17340 tctctgcagg caaccacgtg cactgggtgt caagaaaaaa tatacagggg ccatatcccg 17400 ggttgtcttc aggctcggga agcctgcgac tttgtcccct ttccccggct tcccaacctg 17460 gtggctaaag gcttccagca ggtgtctgcc aaccccatcc acagtcatgg ggcccaatgt 17520 ggcacccaga gaatgaccgt gggctgacag cccagagcca gcggcatccc cggtgaggtc 17580 agtgtcctgg aattggtcaa acaggatcac caggaggatt ccgtgagcac agccagcatg 17640 actcacggcc atgatcagcc tcacgggcag aggctgccaa cctgggatgg ccacagccac 17700 cggctcacct tgcagggcaa cgcacctttt aaggagggag ctggagcagc gcccgggtcc 17760 tgcctctggc caaggcctct gccacacttc tccacgccca cccgggcaga gaggccagac 17820 ccccactggg ttcaaatttg gcaccacttt tcagacatga ccttgggcaa gtcgatttct 17880 ctgaactgtt tttttcactt atgatatgga aataatactt gcctcacaag agtggaattc 17940 gatgaggtaa tgtgtttaga aagtgcgtgg caaacggtgc cttttaagga gcggcagtgg 18000 ggtccggtgg aaagggccag ggctcgggag tcgaggcgcc ccagcattgt gctctggccc 18060 caccctgggc tcactgggtg tctttgaaag agttactcaa cctccgatct gctctgctcc 18120 cactgtgtca aatgagctga caccacttgc cttgttgcct gttgtgagat gaagatcaca 18180 cacacgccac cttctatcag atgacaggag gcagcgaggg tggttcctgg gggtgggtgt 18240 ggaaggctgc ctggccttga atcccagctc agccactcag gggctttgtg acctggggaa 18300 ggctcctcaa cctctcgggg caggtctcag gtggaatctg aagggcaacg ccttcccgcg 18360 gggctgtgct gagctgagac cctcaaaaca gtgccaggta cctgggaggt gcctcctgag 18420 tctgggcagg tcctgctcat cttaaccagg gcttttggcc tttgcaggat gttcactcca 18480 ccagcttccg tctccactga cgccagttgc tggttttgtc ccctccatgt gcttgtgaca 18540 gaccccaggg tctggggtcc ttcagaggcc acgggcccct ctcctccctc ggtctcggca 18600 gccttcccaa ggcagtcctt gggtgggccc ctggagaatg cagacagttc taatagaaca 18660 gggtgagcct ctgagaacag agcaatacca gccccatggc atccctgggg ccacggagta 18720 gggtgtcagg atccccctgc cgccaagcac ctgattcaca ggaagctggg gcctcatcca 18780 ggcaaccgag ccctaatgac agcttggccc taggagcaag gcagacggaa ggaaggcttt 18840 cttgactggc aagcctggct cccttggcac actcctctat ggccaagggg agctgggggc 18900 caagaggggt tgtctggtcc caaggcccag aagttcctgc aggcacccat gggaaggata 18960 gcctgatccc cacagggcca ggcacctgct ggggcagcca ggagccctgt cagttgggga 19020 ggcctcagaa gggtcaaggg gatcagctgt gggagcccag gtttcagagg caaccacgtc 19080 tggatagaaa ccccagctct gcatcccatg agccacagtg tctacatcgg ggtaatgggg 19140 acaacagcct cttgccttag gagggcacga ggactggcac atggcatcct tagaatagca 19200 gccactgctg acaagcatgt tagtgaacag gaagggctgg ttggagagag tgttgtggag 19260 ttaggggagg atgtggggac agtggacaag ccccctggga aagggtgaca agtgctctga 19320 gcccacacag atgtgacatt gcagatggtg cagacccttg ctttatttgt ctgacttgtt 19380 cacagttcag ccccctgctc agaaaaccaa cgggccagct aaggagagga ggaggcacct 19440 tgagacttcc ggagtcgagg ctctccaggg ttccccagcc catcaatcat tttctgcacc 19500 ccctgcctgg gaggcagctc cctggggggt gggaatgggt gactagaggg gatttcagtg 19560 tgggacccag ggtctgttct tcacagtagg aggtggaagg gatgactaag ttctttatca 19620 cagacctaca aaaaatgaga taattagata ttactctcac tagtttgggc ttcttttttc 19680 tttttctttt tacaaaacag cagctggaaa gagaaatgta ggtggcagac gagccaggca 19740 cgaggtttca gattggaagg gaccaagatg aggaccaagg tgtggctgcc tgactaggaa 19800 cgctgtgggc tggcccaggc tctcgccaca catcctggga gaactgccat aggccctaga 19860 aggagggatg aaaggcgtat gggagggaag acagcggtcc ccggatcagc agcagcacca 19920 ccatcctctg atggcccctg ggcagtccgc cagctcggaa gcactcaggg ctggagcctg 19980 ggctctaagc atgggcccca ggagccagac aggagggagg cagcaggaag ggctggcatg 20040 gaagggctga gttctattgg ggtcccacgc gggcaaggga accaggactc atccctgctt 20100 gtcagccaat cagcttcttc aggaaggcct ccaactgatc ctcatccttg atgcccacaa 20160 acttgtccac cacgtcccca ttcttcatgg ccagcacagt gggcaccgct gacacctggg 20220 tggagaggac aagggggtcc aagtgaattg ggagtgaata cttctcaact gccactcctg 20280 agcctttgtg gggaaggctg gtggcttatc cagggcactg acttcccaaa gccatgggca 20340 ggcctagagg aacatggctc ttctctcggt gcaggggtac tgcagggccc gggggccacc 20400 cgctgaagaa acgtcttcca ttgcgggctc ccaacagtac ccttcctccc ttaaccacaa 20460 gactgactca ctggcccagt ggttttgctg gaatgacagg agagatgaaa ataacccttg 20520 cagctgcagg ccagggctgg gggcagggag gagctcaggg gaagcctggc ccaggaggag 20580 acagaagctg ggggacagtt cgagtcctgg ctttgcactc actagcaagg gggccttggc 20640 cgggtcacag cacctttctg agcctcagtg tccttttcca taaaatgggg gtaatgtcta 20700 cctttagggt ttgggatgaa cattaaagat tcaagtatag gctgggcaca gtggcttata 20760 tctataatcc cagccttctg ggagactgag gctggaggat tgcttgagtt caagagttcc 20820 agaccagctt gggcaatata gtgagaccct ttgtttacta aaccccccca aaatattagc 20880 caggcatggt ggtacatgcc tgtactccca tactcgggag gctgaggcag gaggatcgct 20940 tgagcctggg agactgaggc ttcagtgagc tgtgattgtg ccactgcact ccagcctggg 21000 tgacagagac cctgcctcaa aaaaaaagag aaagatttga gtataaagca gagctcaggc 21060 tgggcgcggt ggctcacacc tgtaatccca gcattttggg aggctgaggt gggcagatca 21120 tttgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccctgt ctctactgaa 21180 aatacaaaaa ttagtcgggc atggtggcag gcacctgtaa tcccacctac ttgggaggct 21240 gaggtgagag aattgcttga acctgggagg tggaggctgg agtcagtgga gattgcacca 21300 ctgcactcca gcctgggtga cagagtgaga ctccatctca taaataaata aataaataaa 21360 taaataaata cataaataaa gcagagctca ggttctggcg gacgcaatcc ggctcctacc 21420 agccaggtga gctggggcac gcccctcagt cactaagcct cagtgttctc agatgcagga 21480 tggagatact aagggcactg ccattagagg gcatgaaagc tgaatgaaat aacgcaagta 21540 aaggctcagc acagcgcccg gcaaataagc ttaggaacct ggcattgtgc ctggcatact 21600 gtgggcattc aaaaaacagt ggctacagag ggcacaagga aaagtccaac acaggcccca 21660 cgagagcaca ttagcttgct gctgtgatga gtgacagggt ccagaaactc agggacttct 21720 actggacagc atgagaggag aggcttggcc atacacaacc tgacgcttat tagcaggttg 21780 caggcagatg gcaaggacaa cattcttggt ctgtgaagca tttactcagt tccctcaggg 21840 acctgcatag gttatgtgga acgtggatga ggctgtggcc caccagactg gcattgtgag 21900 gtctctgctg cctgggatcc ctgcctggca ttcgtgggca tttgagaaaa ccatttaaac 21960 agaacaagat aggccggtcg ctgtggctca cgcctgtaat cctagcattt tgggaagcca 22020 aagcgggcag atcacttgag gtcaggagtt cgagaccagc ctgaccaaca tggtgaaacc 22080 ccgtctctac taaaaataca aaaattagcc gggcgtggtg gggcatgcct atagtcccag 22140 ctactcggga ggctgaggca ggagaatcgc ttgaacccgg gaggcagagg ttgcactgag 22200 ctgagattgt gccattgcat tccagcctgg gcgacagagc aagactctgt tccccccctc 22260 aaaataaata aataaaaata aacagaacaa gataaacaca gacttttctt acatacaaat 22320 taaactacaa agtaagagca gagattcaca caaacatacc aggtcttcac atatcccagt 22380 gctgccctgc cacggcccat cttggaagcc agtaagattc agaatgttca aaaaccatgc 22440 acatggtagt taggaaaggc acgcaggcca gaccatcccg ccctcaccca ctaactttac 22500 gtggcaggcc ctgcacccca ctcctcacgg acactttggg gacaaacaca gcaggtcaca 22560 ggacacagtc cttgtccttg ttagtgcctc aggccccttc aaaggctgtc cctgggctga 22620 tgtgggtggc aaaccctgtc tccaggcaga gcagggcccg aaagagtttg ctccaggaag 22680 cgcctgaagc caccagggcc ttcccaggca ttctttggtg ccctctagtg gtctgcaaag 22740 gcagctggag tgcctcaaag ccggagcctc ttggcagaag cagagagctc agccaccggc 22800 tcccacctgc acactgtcct attcctttaa ttaaaatata tgctttatgc cactgtataa 22860 gaagtggcct aacttttttc acggcaagac tctaagttca ctgaagaggc tcagagagtg 22920 gacttagcgt tccttaagaa ctccagatag gcacaagcac agtggctcac acctgtaatc 22980 ccaagtactt tgggaggcca aggcaggagg actgcttgag gtcaggaatt catgaccagc 23040 ctgggcaaca tagcaagacg tcgtctccat aaaaatatta aaaaaaaaaa aaaagaactc 23100 cagatgaagg ccataatgat ctcactcatg taaacctcca cacatgcttg aacacgcaca 23160 gaccctgctg gtgtcaggta gacagcagat gtgctgtcaa tggaggtctg gtcactactg 23220 atcaagggga tattttgaag ttgagcttaa acacacacac gcatacacac atatatacac 23280 acacacacat acacactacc cgcactaggg gctcacagga aacctgagct ggaatgggac 23340 ttccctcgac cctgaggagg cggctgaagc tctgctgctc ctgtgtctgg ctcacacatc 23400 aggaggtgcc ggtgcctgta aacactgcct tacatggaag tgcacagggc cttggcacat 23460 tcttctggaa tgttttgagt gtgaaagagg cagtgactga gccaactgag gggctgagga 23520 aaagatacgc tacgacgtgt tgcctgtcct gttccgtgaa gccacttgga acctcctatc 23580 cttggataaa gaccctctga actcggcagg agtgggggag tgtgtacgtg tgcgcagtct 23640 ctttctgcta acccgtagct cgcctgcacc gccactgagc tccgtgtcct ggtatgtctt 23700 ctcctgtccc accccgatgg catccatctg ttaactcagc taagggccta ccaagggaaa 23760 ggcacagtgc tgggtgctgc gggatgttgc aacctcctcc tcggctcatt gcagagttaa 23820 aaggaaaaga tcgctgtcac atgctgggtg ctttttcgtg tcaggaatga tataaacacc 23880 tctatacact atctcacact ctcctggctg tgggcaggat cattttaacg atgagaatac 23940 tgaggctcaa agggtgagca actgttccaa aatgatgtgg tgtaggacag gcgcggcagc 24000 tcctgcctgt aatcccagca ctttgggagg ctgaggaagg tgaatcatct gaggtcagga 24060 attcgagaca aggccggcca atgtggtgaa accttgtctc taccaaaaat acaaaaatta 24120 ggccgggcgt ggtggctcac gcctgtaatt ccagcacttt gggaggctga ggcaggagaa 24180 gtgcttgaat gcgggagatg gaggtcgcag tgagccgaga ttgcgccact tcactccacc 24240 tgggtgaaaa gagtgagacc ccctctaaaa aaaaaaaaaa aaaaaagctg ggatctgaaa 24300 caagatctgt ttgactttgc agtccagggg atcaaactct gttgtgcttc tgcccagcag 24360 caaagagaga gagacatcta ctgagtccca gcagggggaa gaacgtgggg acgcattaaa 24420 ggatttcatg cttcaaatgc aaaatgccaa gtgctttgta aaagctttta gatatgagag 24480 ggttcttgga aaaacgatta ttgaaaaaat gaactacata acattctggc agaattaggt 24540 agacagtgaa aagatcaaga gtcgccaggc ctggagggag gaggaaggag agatgaacag 24600 gcagaggaga gaggacatgg aggcagtgaa atgactctgg atgatgctag aatgtggaca 24660 ccggctatga cacatttgtc caaacccaca gcaggcacaa caccaagagt gatcccctat 24720 gtaaactttt ggctttgggg gataatgatg tccgtgtagg ttcataagtt gtgacaaatg 24780 gaccaccctg gtatgggctg ttgatagtgt gggaggctgg gcatgcggga ggacagggga 24840 cttatgggaa gtctctgtac cttccccttc ctctcaattt tgccacgaac ctaaaactgc 24900 cctaaaaaca taaaatcctc aaaaagaaca acaacaaaaa atgagatcag tgactgctgg 24960 ggggttaagg gggtgagggg caggaaggag aggtgaactg ctggaaaaca ggggaaccga 25020 gggcggtgga acggttctgt atggcgctgg aatggtggac acatgccatt atacatttgt 25080 ccatgaactt tctcactggc aagcagtctg tgctgagagc ggcagctgag acacggcctt 25140 ccaaagagca gttcctcccc acagaaagtc agtccggggc cttcagaacc agaaagtcaa 25200 tctggggcct tcagaatgaa aaagtcagta tggggccttc agaacattgg,cttctctcca 25260 tgtcggctca ggacacccag ccctggcatt acctgggagc ttgttagaaa tgcagtcttg 25320 gtggccgggc gcggtggctc atgcctgtaa tgccagcact ctgggaggcc gaggtgggcg 25380 aatcacttga ggtgaggagt ttgagaccaa tctggtcaac atggtgaaac cccatctcta 25440 ctaaaaatac aaaaattagg ccaggtgtag tggctcacgc ccgcaatcct agcactttgg 25500 gaggccgagg cgggctgatc acctgatgtc aggagtttga gaccagcctg gcaaacatgg 25560 taaaaccttg tctctattaa aactacaaaa attagctggg cgtggtcgtg ggcacctgta 25620 atcccagcta ctcgggaggc tgaggcagga gaatcgcttg aacctgagaa gcggaggttg 25680 cagtgaaccg agatcgtgcc attgcactcc agcctgggcg acagagcgag actccatctc 25740 aaaaaagaaa aaggatttta ggccttaaag aaagccatca tggggggcac tgtagttctc 25800 tcagaggaaa cttcttcctc aggctctctt cagaaagaaa agaggaagga aggaaagaag 25860 gaagggaggg agagagggag ggggtcagga agaaccctgg ctggagcttc ctaaaccctg 25920 caatgatgtc agaccagggt ttggctaaac aacacggctg agaccaagtg atgtgggcct 25980 agcagccttg aggcctttct gtgtgacagc acagtcccca ggcagtggac agggcgggag 26040 cggtgggtgt ggggggagat tgagaggatt ccacaggagg catctccttc tcacttccca 26100 ggcttcaccg caggccttca gtgcccactc ccacaacagc ctcccgggga cggtcctcgg 26160 cattcccgcc accccacgag acactggagc agggcctgtg ggcttctttg catctgcagt 26220 agttaccata gtccctgcac atggctggcc ctcagggggt gtctgctgaa gagttatgaa 26280 tacattggct gaagctgaag ctgtagtgtc tggcagagcc aggaggcctg agacatctga 26340 agcccacgcg tgacctgtgg gaggccctag gagccccagc ccgggetctc acccgaggca 26400 tagccaggca ggggaaagcc aggggcatcc aaatgggcag atagatgcct ccctcactga 26460 gcaatcagtg gccaaacttt ttgaaaaagt gactcacccc tcccccagcc cctgtaaaca 26520 gccctcagtt cctaactccc aaagcaggcc tgctccagtg gtcacctgta gtggccaccg 26580 tgtttgtctg cctggtctcc atctcccctg cttctggtca ttgcagactg atgttccttt 26640 gggtaatcac tccccactcc ctgcgtagct caaggggcgg ccagcctgtt ctcaccccgc 26700 tcccaaccac ccatttcttg ctgcaggaga ctggttcagg gatgggtgcc tctatttgag 26760 ctggtctagt aagagtgaaa cctggacttg tatactctga ggaataaagc ggcctctttc 26820 attcacttgt tacctggagg aggaaggagg gaggggtgaa ggctcactcc ggccaggtta 26880 agatatttca agaaaatcag atatcgagat tttcacatga aatctgagtt tcaaatatca 26940 gcatctgctt cctattactt taaaatactt cgagtgccag actaaaagtg tctgtgagcc 27000 aggttgggcc cagaggctgc caggagcgcc ctcggctctg taacagcgct accttcagca 27060 tggctattca gagaccctcc caatccggct gcattatgct ttccccagct ccgtactcgg 27120 cccttcactc tggccaccca gacaaagtgg gcctctcccc tttctccagg tagtggtctc 27180 caaggcccag aggaagcccc caacccagac acctceaggc acctggcccc tgctggtctg 27240 taagcaaccc aggctcatca gacctcaggg cttttgcttt gcctgaattg ttcttccaaa 27300 gacccacatg cttcagtcac tcccttcctg tttttgccca aaggtcagct tatcagggag 27360 atctacccta tcccaccctt taaaaaagaa acccgctggg cgcggtggct tacgcctgta 27420 atcccagcac tttgggaggc caaggcaggt gggtcacccg aggtcaggag atcaagacca 27480 gcctggctaa catggtgaaa cctcatttct actaaaaata caaaaaatta gccggcgtgg 27540 tggcgcgtgc ctgtaatctc agctactccg gaggctggga caggagaact gcttgaaccc 27600 gggaggcaga ggttgcagtg agccgagatt gtgccactgc actccagctt gggcaacaag 27660 agcaaaactc tgtctcgaaa aaacaaaaac cctgcctcat acgcagtact cccatcctct 27720 cttcctgatg tatttttctc cattgaactt attatctaaa acaggggtca gcaaactata 27780 gttcacaggc ccaatacagc ctactgcttg tttttgtaaa taaagtttta ttgtaacaca 27840 gccatgccca tttgtttgta tagtgtctat ggctgctttc ggctacgagc ccagctgaat 27900 ggttgtagca gcgaccactg ccctgcaatg cttccaatac caaccagtcc tttagagaaa 27960 aagtttgctg acccttgatt taaaatacta gaatgtagac tccacggagg cagagatttt 28020 gtcagttttg ttcactgcct tatcctcaac accaagtaac actacctggc acttgaggga 28080 ctctcaaata tctgctgaat aaacagacaa accaaccaac caagtgagac gactccatgt 28140 ctttgtgcac gctgtttcct cagcccttcc tcctcctctg cgcatccctc atggctcagc 28200 tcagaggttc tctctaacgt gaagcattcc ctgtcccctc cagctccccc acaagcaaac 28260 agtcccttct tcctttatgc gcctcttctt ttagcacttc tatattgaga tgatctttct 28320 acctgctgtt ctctcctgct agactaggag agatcttgct tggaaacaag atctcatctt 28380 gtgtcagaat cacaaatgct tggcacatcg agctcccaaa tgactgctca ctgaacatgt 28440 gggtagatgg ataaaggaat gtaccaatgt ctgagactaa gtgaatgacc tggtgttttt 28500 gggtcatacg atctacttcc taaaggtggt gaagagagac.aggtggctca gaggatcaag 28560 agccacctct gcaaagtgct ctgagctctt aaaagctctc gaaaaaccgg ctgggcgcag 28620 tggctcatgc ctgtaatccc agcactttgg gaggccaagg tgggtggatc ataaggtcag 28680 gagttccaga ccagtctggc caacatggtg ataccctgtc tctactaaaa atacaaaaaa 28740 ttagctgggc gtggtggtgt gcgcctgtag tcccagctac ttgggaggct gaggcaggag 28800 aatcgcgtga acccgggagg cagaggttgc aatgagccga gatcatgcca ttgcactcta 28860 gcccaggtga cagtgagaga ttccgtctca aaaaaaaaaa gctctggaaa aaccaagaca 28920 ccttgcttac tggctacctg tgctccccaa gatacctcct acaccagcta tccctgggcc 28980 tgacacctcc tatactggct tccctgtggc aactccctgt caatccatac ctcatactca 29040 atggcgaggt ctgtgtggtc atcaatatcc accttggcca tcaccacctt cccgtgctgc 29100 ttggccacca tcttctctaa cctcggcccc aggatcttgc agggtccaca ccacctcaaa 29160 aggcgagaaa ggaagcatcc agtcagtcaa aagagcgctc agcatcccct actggcttcc 29220 cagacctgca tctttccaag gaatcttttg cccttattat ctctgtttac catgtttaaa 29280 aattaacaca ccaaatggta atgccaggag attctgcaca tgggaaatct tcacagatcc 29340 cagactttta aaacacaggc ctcatcagaa gactcataat aaaagtgact catttcagta 29400 tatctcagat aaatatactg tcatataaaa ggatatggga ttggaagtta aaaggttcaa 29460 acagaggctt ctcaccaacc agctgattat tctggggccc tagtttcctt tttttctttt 29520 tttgagacgg agtctcgctc tatcccccag gctggagtgc agtggcgcga tctcggctca 29580 ctgcaagctc cgcctccctg gtttacgcca ttctcctgcc tcagcttcct cagtagctgg 29640 gactacaggt gcctgccaac acgcccagct aattttttgt attttttagt agagacgggg 29700 tttcaccgtg ttagccagga tggtctcgat ctcctgacct cgtgatccgc ctgtctcggc 29760 ctcccaaagt gctgggatta caggcatgag ccaccgcgcc cggcctgggc cctagtttct 29820 tcatctgaaa aagagagatt atggctctca aagctattag gagagatcaa ctaaggcaat 29880 gtgggtaaac atgcattgga agctgtgggg atatttcaaa caccatgtgg actcagaact 29940 aaaaggaggg gaaccaatgg cctggagcgt ctacaacgca ccagtccctg gctcactttc 30000 tctgctttta ccaaacacac ccctcaactc tgcaaagaga acacaccttc caaagaaact 30060 gaagcccata cgagttaaga aacctgtgca agattagaga agcacagctg ggatcgatca 30120 caacccaaag ctgtgttgaa agtgttttct ttggccgggt gcggtgaccc acgcctataa 30180 ttccagcact ttgggaggcc gaggcaggcg gatcacctga ggtcaggagt tcaagatcag 30240 cctggccaac atggtaaaac ctcgtctcta ctaaaaatac aaagattagc caggagtggt 30300 ggtgtgcgcc tgtaatccca gcttctagga aggctgaggc aggagaatca ctttaacctg 30360 ggaggcagag gttgaagtga gctgagattg tgccactgca ctccagcctg ggcgacagag 30420 actctgtctc aaaaaaaaaa aaaaaaaaaa aagagaaagt gttttatttc acccacaggc 30480 tactctgatc ccacagcccc tgagttgacc attatcactg ccctgatcat aggtattccc 30540 ctctcgctgg ggaagctcat ccaggacagg cctggtgctg tcatctctat gtatgtggca 30600 ccaaggaaag tgcctggcac tgaatgaaca actcacacca ccccacttcc ttactgaaca 30660 aaatgaggca ttatcccatt tattgttcat ttcggaaggc ctctctggaa tgctcactac 30720 accaggaggc caagacagtt ccacctttca caaacccctg gctgacaact cctattttat 30780 tctcagcact tacttattta tttttgagat ggagtctcac tctgttgccc aggctggagt 30840 gcaatggcgc gatctcggct cactgcaact tccgcctccc gggttcaagc aattctcctg 30900 cctcagcctc ctgagtagca ggtgtggtgg tgcacaccgc acccagccag gcctgacggt 30960 tttaaatgct gaaaaatagg ccgggcataa tggctcacac ctgtaatcct agcactctgg 31020 gaggccaagg cgggagagaa tcacctgtgg tcaggagttt gagagactag cctggccaat 31080 atggtgaaac cccgtctcta ctaaaaatac aaaaaaatta tctgggtggt agtcccaact 31140 acttgggagg ctgaggcagg aaaattgttt taactcggga ggtggaggtt gcagtgagct 31200 gactgaacca ctgcagtcca gcctgggtga cagaatgaga ctctgtctca aaaacaaaaa 31260 aggaaaaaaa accctcaggc ctggcgcagt ggttcatgcc tgtaatccta gcactttggg 31320 aggccaaggt gggaggattg cttgagatca ggaggtagag actgcagtga gccgtgatcg 31380 caccactgca ctctacattc tagcctgggt gacagagtga gaccttgtct ctaaaagaag 31440 aaaaacaaaa acaactcata acactgaaaa acccagtgtg caagacctta tctcctatta 31500 caagtgaaga aagggagcac aaagatatca agtggcctgc ccaaggccac agggtgagtc 31560 agagaaacaa ctggaaagcc agcgaaacaa tctgtcagag acctgaccag aaggcccttc 31620 aatttctttt tctttttttt tttttttgag atggagtttc cctctgtcac ccaggctgga 31680 gtgcaatggc gcgatctcag ctcactgcaa cctccacctc ccaggttcaa gcgattctcc 31740 tgcctcagcc tcttgggtag ctgggattac aggtgcccgc caccacgccc gattaatttt 31800 tgtatttttg gtagagatgg ggtttcacta tgttggctgg gcaggtctca aactcctgac 31860 ctcaggtaat ccacctgcct cggcctctga aagtgctggg attacaggtg tgagccactg 31920 cgtccgacct gaaggcccct gaatttttaa cttatgctac actggtttct cccaggatgc 31980 ctcattcaga gggctttgtc cagcttttgt gtagttgggt gtctagccag gccccaaaga 32040 tctagaaatg aaaaagccca ggctaaaatt cagaaggcca gagggactta aatatctcta 32100 aagcaaactc agatagcact gaaaggaaac tccttcctat gccctgtatg cttgggcacc 32160 acggtagtga caccgataac tttttttttt tttttttgag atggaatttc actctttttg 32220 cccaggctgg agtgtaatgg cgcgatcttc agctcactac aaacactacc tcttaggttc 32280 aagtgattct cctgcctcag cctcccgagt agctgggatt acaggcacac accaccacgc 32340 ctagctaatt ttgtattttt aatagagaca gggtatcacc atgttggcca ggctggtctt 32400 gaactcctga cctcaggtga tctgcccgcc ttggcctccc aaagtgctgg gattacaggc 32460 atgagccacc gcacccggcc gacactgata actttttgcc agcccttctt gcggttttca 32520 tggcaggatg ttaacatcag cttatctgca gggccaggaa ctggtataca ccaaaagcaa 32580 ggtgacagtc atatttttcc aactctggtc catgctaaag atgacgctga gctttctggg 32640 gattgagaaa cagaacatgt gtttcccagc actaacagtc agctttgcag actgttcact 32700 tgtctgtctt ccaccagact gcattcccct tgagggcagg gactgggcct gaccagtctg 32760 tatattgagt ctacatatga gcagcataga acatggccgt gggacacagc aggcattcaa 32820 taaatacttg aacaagtagg accctagtct tctgtggacc cccaatactc actgtgcgtg 32880 gaaatccaca accactggtg tctcactgtt gaccactcgg tcttgaaagt caggtccatc 32940 ctggatatta aaggttgtca aggagatcct cgtggtgtat attgtccggg ctgggttggg 33000 tgttacagtc aggccaccag gactgcattg tggggtctgc agggctctgg aagtgagggg 33060 tggccactga ccctgagagg gcttcctgga gatgacagag gccaggaacc tcctcagaag 33120 aagtcgctga gccatctgtg agggaaagag gcagaagaac tggggcacac aaaaggaagt 33180 cgacacacta gaaaaagatt tggggagtac tcagggctca ggaagaggca gagttggaag 33240 caaaatgcaa ggaaatcata tgtaagattt gtagcgtgga agtgaggaag caatgagaat 33300 caaagggaag gaacagctag gcaaaccaga aggacaggaa aactggcttc acaaccaaaa 33360 agaaatcggg atttagatta taacggaaga atgggaggaa gaaaccaaca gatttaataa 33420 tgtatgtaag gaccaagtac cttacacaca ttattggtct tcctacagca acttccagga 33480 agttgctatt gtactgccca cactgcgagt aagggaagga atacgaggct caagtaagtt 33540 aagtgacatg cccaaagtaa ccccgctatt aaatgacagc caacactgga acccagggtc 33600 gtctgaaaag atgaaacgca acaattcaag gaggaactaa gagtgtgaga ggaaccaaaa 33660 acgaagagac atgtactgga gggaaccaat aaagaaggga catgtgtgga gggaactggg 33720 aaaaatcgga catcaccagg gaccctggct ctccggcgag ctagatcccc ccgcccgccc 33780 ggccgccagc ctgcgcagga acgcgctcgc ggcatgcctc agccgcgaca ccacctcgag 33840 ccacccccac agggctccta cctccctgca atgcgagcgg agggatgcac agcctagccc 33900 tccctgcctg tcaagggcac gcctgtcgtc acttcctcgg ggggggacgt acataacgtc 33960 acttccgggt acaggcaggc ggaagagcgt ccctctccaa tttttttttt tttttttttt 34020 ttttttgagc cagagtctcg ctctgttgcc aggctggggt gcagtggcgc gatctcggct 34080 cactgcaacc tccgccttcc gggttcaagc gattctcctg cctcagcctc ccgactagag 34140 gcgcgcgcca ccacgcccag ctaatttttt tatttttagt agagacgggg tttcaccacg 34200 ttggccagga cggtctcgat cttttgacct cgtgatccgc ccgcctcggc ttctcagagg .34260 gttgtgatta cgggcgtgag ccacagcgcc catctgtccc tctccaattt gaggggcgtc 34320 tgggattttc cgccaatggg aatggcgggc tgaggcacag ttgaaggggc ggggcctcag 34380 ctacggaccg gaagcaatgg gcaggccgtc ggggaacgga ttggaagagg cgggcgggcc 34440 ctggtctggg cgaaggcggg ggcggggcgg ggcggaaacg gaaggggtgg gcgggcccta 34500 gaggagggac cggaagagga ggtgatggag caggggtagc aatggagggt acttaaggga 34560 gaaaaggcag ttgagaagtc cccgtggttt tggattttgc aaactcttgt tgctttattt 34620 tatttacata tatttattta ttaatgacag agtctcgctc tgtctcccag gctacagtgc 34680 agtggcgtga tctccgctca ctgcaacatc caaatcccgg gttcaagtga ttttcctgcc 34740 tcagcctccc aggtagctgg gattacaggc gcgcgccacc acgccgggct gatttttgta 34800 tttttagtag agacggagtt tcgccatgtt ggccaggctg gtctggaact cctgagctca 34860 agtgatccgc ccgcttcagc ctcccaaagt gctgggatta caggcgtgag ccaccttgcc 34920 tggcctcctg tttataactg gcgctgtcca cttcctacag atgttgacag gttctgtttc 34980 tccatttaat atgtaaagct aagctcctca aaggcatgat gccctttata tgtaaaagaa 35040 ctcaaccggg agtttagggg ccatccttta agtggccctc gtctgtgtcc gcctaaagga 35100 aaacaaatga aaactgaggc gagcctaatt taagcaggga gtttttttgg gtcaagttcg 35160 aagactgcaa ctcggagcag agattcaagt tgtcctgaat atacactcgg attagcagca 35220 gctgaaagag cgtttttaaa agaacaggca gtttccaaat tgttgatcaa agtttttttt 35280 tttttttttt ttttttttga gacagagtct cgctcttgtt gcccaggctg gagtgcagtg 35340 gcgcgatctc ggctcactgc aacctctgcc tcctgggttc aagggattct tctccctctg 35400 cctccccagt agctgggact acaggcgtgc ctcaccacgc ctagctaatt tttatatttt 35460 tagtagagac ggagtttcac catgttggct aggatggtct cgatctattg acctcatgat 35520 ctgcccacct gggcctccca aagtgctgga attacaggcg tgagccactg cacccagcct 35580 tttttttttt ttttttgaga cggagtcttg ctctgtagct aggctggagt gcagtggcat 35640 gatcttggct caccgcaacc tccacctcca gggttcaagg gattctcctg cctcagcccc 35700 ccaagtactt gggattacag gcgagcacca ccacacctgg ctaatttttt atatttttgg 35760 tacagaaatt ttatatttca ccatgttggc caggctggtc tcgaactcct gaccttaagt 35820 tatcgctcgc ctcggcttcc caaagtgctg ggataacagg cgtgagccac cgcgcctggc 35880 cgccctgccc atttttgtat cggttttctg tgtctctagc actttctttt ccacagccac 35940 ctatcaatcc tattcagcac ttccacagta ttttctagag agccaatttt cctgcctaat 36000 tcacattctg aatttcacag gcggaccagt cctgtttgtc cttatgccat agtcacttca 36060 ccctgatcgg cctcaggctt ctcatctgag caatgggaag aatgcctttc tcatagctgg 36120 gctgagggtt gcagtagaga cagaatccac atcattgctg cctgatgact cctgcaggga 36180 aagcctgaga gacacagaga aggctgagct ctcggcgcgc tacaaaaggg ctctcagcta 36240 catggtggct cctctgtcca gctagagctg agctggcctg ggtctggctt agtcacaagc 36300 aggctcaggg cacagctgag aggcaaaggg aaggaagcca ggactggcag cctgggctaa 36360 gggtaaaact tctacctcct accaatattt attgcagtgt ttttcaaact gcaggatatg 36420 gacgtcagtg ggtttgcaaa attaatttag tgggtggtga tctgcttttt aaaaaaacaa 36480 acatggtgcc aggcgtggtg gctcacacct gtaatcccag cactttggga ggccaaggcg 36540 ggcagttcac ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccatc 36600 tctactaaaa atacaaaaat tagccaagcg tggtggtaca cgcctgtagc cccagctact 36660 cgggaggctg ggcaggagaa tggcgtgaac ccgggaggcg gagcttgcag tgagccgaga 36720 tagtgccact gcactctggc ctgggcgaaa gagcaagact ctgtctcaaa aaaaaaaaaa 36780 aaaaaaatag ctctaaggtc ttgcactaac cggtatgacc tgtctggcgt ctttacaggc 36840 agtattggaa tgttataggg agacatacag ggtttaagaa atccatcacg gagaagacct 36900 tcaattatca attataggtt ttaaatttac ctcggctttg aaaggaatag gatacattgc 36960 tttctcttta ctacttcccc aggggtttgt aatttaacat gaaactgagt aatctgtaac 37020 tttcctcgat tctcgtcttt tgaccatacc ttgggatgaa tgagttcttt gtctgtggtg 37080 gggagcaagt ttagggaggg gaggaatctt ccctgattaa tatagaggcc taagccaaat 37140 tttagcatta aatctctcta ataggtttgt tcctgcctct ggaataaaca gaaatttaat 37200 attagctgat ttgcttttat atatgacttt tgttcttttt cccatttggg acattttctt 37260 ttgaagtgac ctatttttaa tctgaaacat ttattttgtc ctctttctct ccctttgcct 37320 ctccctctct gcctcttttt ctctctcact ctttctcttt gcctctctct ctgcctctct 37380 cttcctcttt gactctctcc ctttgccttt ctctctgcct ctctctttcc ctttttgcct 37440 gtctctctct ctttgactct gtctgttctg tcagtctttc tctctcctct aagttttttt 37500 tttctttact tttgagtctc ctggctttac tctttcatac tctatatatt gcctggagag 37560 tgggggtcta ggttcttttt tttttttttt tttttttttt gagacggagt ctcgctctgt 37620 cgcccaggct ggagtgtagt ggcgcgatct tggctcactg caacctccgc ctcctgggtt 37680 cacgccattc tcctgcctca gcctcccgag tagctgggac tacaggcgcc caccaccatg 37740 cccggctgct tttttttagt agagacgggg tttcaccgtg ttagccagga tggtcttggt 37800 ctcctgacct cgtgatccgc tcgccttggc ctcccaaagt gctgggatta caggcgtgag 37860 ccgccgcgcc cagccctcag tctaggttct ttataggttc tggccccctg ggtactttgt 37920 tgtatggtag acagcagaat ttttgccttc tgcttttgtt tttcatcatc ttttcttata 37980 tatacctttt gggcttctct tagaagctct tctataggtt tatctttcca gttctctatc 38040 ttttgtaatt tcttgttaat atctggccaa ctgttagtga caaaatgaag ttttaacatt 38100 ccctgcccaa gaggatcctt gagacctaga ccagtgtatt ttctcatttg ttcctttaat 38160 ctatctaaaa attctatagg cccttcatct ttcccttgct gtatatcaaa tattcgggta 38220 agatactgag ttcggggtac caattttttt tttttttttg agatggagcc ttgctctgtt 38280 gctcaggcta gagtgctgga gtgcagtggc gtgatctcgg ctcactgcaa gctccgcctt 38340 ctgggttcac gccattctcc tgcctcagcc tcctgagtag ctgggactaa aggcgcctgc 38400 cactatgccc agctaatttt tttgtatttt ttagtagaga cggggtttca ctgtgttggc 38460 caggatggtc tcgatctcct gaccttgtga tctgcctgcc tcggcctccc aaagtgctgg 38520 gattacaggc gtgagccact gcgcccagcc tcggggtact gatgctttaa tcccctttat 38580 tatcaattcc ttaaggtcct gcatattttc tcggtgggct gcgttgttat tgtcccactg 38640 ggggtcttgg gtgggagttt tttgatctgc tgtaggaacg ttttggccag gagggtgttc 38700 gtgttcctag gctcccatag cagctctatg gatcatgtct ctttcttccc ccgagaagag 38760 gggaaaggga aattctgaat atctttttta cattgctcta tctcacgttg aagtccttta 38820 agggaaaggt acttaggtcg gtagtgagtg ggctcttggg acgattctca agaggcaggg 38880 ttgtaagaaa ggggacatca gagataggag aagggtctgg gacagcagct gcttttgttt 38940 ttggtccttt cattatcctt ctaacatttt aacattaggc ctgggggaat attactgttg 39000 ctagctttct cctttttatc tcttacctta cttggggcat ttcccatctt gggtcctggt 39060 taagctcaat ctcccctgtt ggagatgtct cgcctatcct ttagccccac ctgctggagg 39120 ctccttgcat tcatgcacac tttcaacccc cagaatatcc tgaccaccaa ggaaatactt 39180 tgtcacccct gcgatgtttc ttagcttggt ctctgcacac ttacttggtc gctgtggtac 39240 atgaggatcc tttcccccag gtcgccagcc cgtttctttc tgccttgctg agagtatagg 39300 tttattcgtc acactggttg gtctcgattc cttacccctg tggccaccgc aacaaggcag 39360 tgggacgtgc ctcctcatgg gagaggtcta gaccctcctc agaggaggat gggaatccca 39420 aatgagaccc caaatttgtt agaaataaat tttcagtgcc acaaaagaaa tagcactcaa 39480 acatacattt tctcagcaag gcaattttac ttctatacaa gagtgcgtct catggatggt 39540 gcaatggcga gagcacaccg gaacaaggga ggggaatggg ttcttatccc tgatgcaggt 39600 accccctact gctgtgttgt tcccctatgg gctagggttg gaccgcacaa tctaagctaa 39660 ttctgactgg ctattttaaa gagagcaggg gtataagcca gagtggtggg gtgagaagtt 39720 tagacaggaa agatggttac ggaccaggtg actaaaggtg actcaggtca gagcaggtga 39780 cagaggctag gaggggattg tttactgaaa ctaggggcaa ggagacataa agaatgagga 39840 aattaaaagt taaaatgaag aacaaagaac aggtgagctg aacatactga tacattggtt 39900 ctttggagag gatctcagaa ctcaatgtac ttaacaaatt acaggctaaa acctttgaag 39960 aagaatttat gatatcctac attatcatgg ggtaaacaat tcgtccctga cagaataagg 40020 ctactggagt tctcttcttg taactctggg aaggactaga gggaactgtg tctgcagtgg 40080 ggccaggtag ttaaaaagtc tggactgggc cgagcgtggt ggctcatgcc tgtaatccca 40140 acactttagg aggccaagac aggtggatca cctgaggtca ggagttcgag accagcctgg 40200 ccaatgtggt gaaaccctgt ctctactaaa aatacaaaaa ttagctgggc gtggtggcag 40260 gcgcttgtaa tcccagctac ttgggaggtt gagggaagag aattgtttag acccgggagg 40320 cagaagttgc agtgagccga catcgtgcca ttgcactcca gcctgggtga caagagcgaa 40380 atccattgca aaaaaaaaaa aaaagaaaaa gaaaaagtct ggaccaagcc aagaggggaa 40440 gaggacgtcc ccatgaaaga gctttggatc cagaaagccc gggttcttgg aattcttttt 40500 ctcttttcac ttttgttgta gcatactttg ttctttttta ttttttattt ttttgagatg 40560 gggtgtgggg gctttactgt gggtcttgct ttgtcaccta ggctggagta cagtggctcg 40620 gtctctgctc actgcaacct ccacctccca ggttcaagca attctcctgc ctcagcttcc 40680 caagtagctg ggatgacagg catgctccac catgcccagc taattttttt taccgttagt 40740 agagacaagg ttttgctatg ttggccaggc tggtctcgaa ttcctgagct caggtgatcg 40800 gcccactttg gcctcccaaa gtgctgggat tacaggtgta agcaactgta cccagcgcat 40860 gttttatttt aatttaattt aattaactta ttttttgaga tggagtttcc ctcttgttac 40920 ctaggctgga gtgcaatggc gcaatctcgg ctcactgcaa cctctgcctc ccgggtttaa 40980 gtgattctcc tgcctcagcc tctccagtag ctgggattat agacatgtgc taccacgcct 41040 ggctagtttt gtatttttag tagagatagg gtttctccat gttggtcagg ctggtctcaa 41100 actcctgacc tcaggtgatc cacctgcctg ggcctcccag agtgctggga ttgtccttgg 41160 aattctgagt ggatacatga agagttagta agaaccagtg aaaaagcaat cacttatgat 41220 cctgggcttt gaaaaatcac tgtgattatc ttatgcactt acaaatgaga ctaagacgcc 41280 tgatgggaaa gtgcagattg ctggtgagga agggcaatga agaagagact aggaaccaaa 41340 ttcatcatca ttatcacaca aaggcatttg gaaatgtcac cttacacatg gtgagcacat 41400 atgggtgcca gcccgagaca gcaggataag tttcacaaaa cttgaccagg caggttagaa 41460 gcaaggcatg gttcaggatg gcagagggca gggagacaga agggagtagg atgggagaga 41520 agagccagct ggaagatgag tcagggggtg caactgggga gagcagctct gaatcctgct 41580 tctcagtgag aaagttgcta agatggcttt gcagggagct gtcctatcgc tgctcgagat 41640 cagcctgctg ggcctatgat gataagcagg gctgaccctc ttgggctctg tagctaagcc 41700 caaaccctgc tgaaaatggg gcggggaggt tgaggcagtg tgtggcaagt gacacagacg 41760 gggactccca gctgggggtc cctggaatta cttgacatcc cacagctggt gtcttcagca 41820 gtcatctggg gcaacaatcc cacctgccca ttgtggttgt tgaggatatc agagcttttg 41880 ttttaaagcg cttgccacaa actcttaaga tgcggatggg tttcccctgt gaagcactcc 41940 acaggcggga tgcaggccca tctgaggagg ggcttggaag gaagaggagc acttgagacg 42000 gggcagaact gggctggcct ggggctcagc gacagctcca ttgcagacaa actgggctgg 42060 ggaaggcagc tcccacctgg cagaggatgc ccttctgccc cctgacagga gggaggagac 42120 caccgcatcc ccgactttca gccctcacgt gccatctggt ggctttgctg cagacactgc 42180 catgatctga gtggtctttg gcaatcacgc attggcggga gtgtgaggtt gcggggaaag 42240 agggactgac catgggccta ggtggggagg cctggccact gtgcccacag cttaggaagg 42300 gacagtcaga gctcctcttt gttgctatcg acggactgag ccagaggccc tggagccagg 42360 ggggaaccta gtggctcttg gtcgccaagc tgctggctgc tgtcctccag gcgcctgcct 42420 gtgggggcat agtcccgcag gagcctgctc tccactctgt gctgccaaag gctctcggta 42480 ctcacgagtc cctgcatcct caggtacccc tgctggcaaa agggtggcaa cttctggcgc 42540 gtgagggcga acaggaagca ggactctaca caaaagcaaa atgaggagaa tgagccaggc 42600 tgggacatgt ggggaggggt gcagaaaggg gagctgccaa tgccaggtgt gggggcttca 42660 ctgcaggcct tgcctggtat cttccatccc ttgaaactgg gagctgacct ttctgggcat 42720 ctcacgtcca acctgagtag gtcatgaatc atgaccctcc acgaggctcc agggcagggg 42780 gctgccttga cactctggaa gaacaaggct ccaaaataaa agcaaaccac agcaatgcct 42840 cagctcccag acatcagggc tgagcaccgg gctctgcagg caaccacact gggggcgggg 42900 ctccgacctt catgagcaga ccctcggcct ggtgcggctg ggaactcagt ggtcagttcc 42960 actgtgagct cagatctgcc tgcaaagacg cagtccctca acaacatttg agttgcaaat 43020 accatgtgca aagttctgat ctaaacagtg tgggggataa agaaaaacgg gtatatcctc 43080 atctgtccca caacagaaag ctggtgcatg aatcaaattt ggtcaatcat aagatagctg 43140 tggatactta tcatgtagaa atatgaagaa acggccgggc gtggtggctc acgccttaat 43200 ccgacaactc tgggaggccg aggccggtgg atcgcctgag gttaggactt cgagaccagc 43260 ctggccaaca taatgagaaa gaaaccccgt ctctagtaaa aatacaaaaa ttagccaggc 43320 gtagtgacaa acacctgtaa tcccagctac tcgggaggct gaggcaggag aatcactcga 43380 atccaggagg cggacgttgc agtgagccaa gatcgtgcca ctgcactcca gcctgggtga 43440 cagagactct gtctcgaaaa aaaaaagaaa gaaaaagaaa tatgaagaaa caaccaaaag 43500 aagccatgca aagagagaag ctactgaaag gaacaaccgc taggtctggg agttcctcgt 43560 gggaatgaga atgaaggtag ggaaagcggg tgacatagtt tgggtctgtg tccccgccca 43620 aatctcatgt tgaaatgcaa tctctaatgc tggaggtggg gctgctggga ggtgactgca 43680 tcacaggagt ggtttctttt tctttttttt tcttgaggca gagtctccct ctgttgccca 43740 ggcaggctgg agtacagtgg cacgatccca gctcactaca acctctgcct tctgggttca 43800 agtgattctc ctgcctcagc ctccccagta gctgagacta caggtgcccg ccaccacgct 43860 cagctaattt ttgtgttttt taagtaggga gagggtttca ccatgttggc ctggcttgtc 43920 ttgaactcct gacctcaagc tatctgcctt tctcggcctc ccaaagtgct gggattacag 43980 gcgtgatcca gcatccagaa atagatgctg ccatgcgtcc atacagcctg cagaactgtg 44040 agccaattaa acctgtttct ttataaatta cagtctcagg tatttcttta tagcaatgtg 44100 agaacagact aatacagtga gaaaaagtca tttagccaag tacttataag actttaaaca 44160 aacagaagag ctgacacaga tatgggctca gccttctgag ggagttagag acaagggcag 44220 acagagtgtc aggaatgggc tggagtcctt ctgtaactct gagcgagcct tcttgcctcc 44280 ctgagcccct ctatctcaag tgaaaaatgg gcacagcaca aaggatgtcg tgaggcttcc 44340 atgggtgacc aggctgaaag gtgctccaga aatatgactt cctgtttatt tctgactctt 44400 agcatggagg cccctgggag gccaggccat ggcaagcctc tccaagcggg taagagagca 44460 gatgaggaag aggacagcgg gaagactggg agggcagcaa ggtggctgtt tggcaggcac 44520 caccttctga caacatcatc ccttctgcag ggggctcaga tgctcagcag aatctggggc 44580 cagcactaac agctgcacat cagctacagt aacagaggga cggctgccac tatgccagct 44640 ggccgcctgc tgggcggatt ctctccagtc caaggcagca gcacacagtg gcctgtacag 44700 tcaaacagtg tctagaaagt gggagacagg aggctaaagg gcctgggaca atgcattggt 44760 gggacccaca actcagggtg ggaattcact ccctcacaca ccctggcatt tttgttgttg 44820 ttggttttga gatggagtct cgctctgttg cccaggctgg agtgcagtgg catgatctcg 44880 ggtcactgca acatccgcct tccgggttca agcgattctc ctgcctcagc ctcccgagta 44940 ggtagctggg attacaggca cccaccactg cccccagcta atttttctac ttttagtaga 45000 aatggggttt caccatgttg gccagggctg gtctcgaact cctgacctca ggtgatccac 45060 ccacctcggc ctcccaaagt gttgagatta caggcgtgag ccactgcacc tggcctaaaa 45120 gtgtatttct tgagaaggtg tgcatttgct tctgtgattt ctatagctca atgatctcat 45180 gaagtttggc cccaaattta cataagcagg gcctactggt tgaatatttt cagagatttt 45240 tctctcccac tctatctagg gccaaaacca tgcatgtcat ctatctcctc ctttggaggg 45300 ttttggctcc cagcttccct actgagatcc aagctttatt ggagtgtctc taaacaggcc 45360 tcccatcctg ctccagctct gtcttcccac ccatacctgg ccctggcgcc ttcccatggc 45420 gcctggccct gctaatcctt ttgaaaagac atattatcag ctgggtgcgg tggctcacac 45480 ttgtaatccc aacacttcag caggctgagg caggcggatc acgaggtcag ttcgagacca 45540 gcctggccaa tatggtgaaa ccccatctct actaaaaaat aaaaaaatta gttgggcatg 45600 gtggcatgtg cctgtagtcc cagcttcttg ggaggctgag gcaggagaat cgcttgaacc 45660 cgggaggcgg aggttgtagt gagctgagat tgcgccacta cactccagcc tgggcaacag 45720 agcgagactc catctcaaaa aaaaaaaaaa gaagacatat tatccattat ttttaggtga 45780 gttgtaattt aacccacggc attgtcggga acagtagtct ggggtttgga tttccagata 45840 tgggtcctga aactccacgg gtcttgggtc tctgtgacct ttcttcaacc tggagctcag 45900 accctttgtc tttctgggag cttaagttac ctgcatagaa gcttcgcaaa tcggtgtcca 45960 aacagttctc caggaagcgc ctcagaggta ggatgtgccc gatcggggca gtccagtctg 46020 ttaagaagtc ttccacgatg tgatggatgg ccgtgggccg aggcaggggc cagtgtgcag 46080 ggcggaacct cacctcctgt tctgtgggga ggagagaggg ggccatgtca gagctgtgag 46140 gctgggcttc ccctcctcgg gccgacacag cacggatccc acacagccca aacacttccc 46200 tcgttcactc gtgctcggct ttcccgacag cctcctatgc tgggctgtgg tcagactgtt 46260 caagagccac ctgcagatat ttgaaaggct gccatgagga agaggaacta ggcttttccc 46320 ttgtggtttc ggaaggcagt gctgaagcta acaacgtgag gctggcgttt ccctaagact 46380 cacatggact gagatctact gtggctgctt tttattttgt attattattt gttggagaca 46440 gtctcgctct attgcccagg ctgtcatgca gtggcacaat ttaggctcac cgcaacctct 46500 acctcctggg ttcaagcgat tcttgtgcct ctgcctccag agtagctggg attacaggtg 46560 cccgccacca caccgagctc atattttaca tttttcgtag agatggggtt tctagtctct 46620 accatgttgg ccaggctggt ctcaaactcc tgacctcagg tgacccaccc gcctcagcct 46680 cccaaagtgc tgggattaca ggcatgagcc actgcgcctg gctgtggctg ctttcaaact 46740 ggcctttctc tgagaagact cagatagagg cgaggggtct cagcactcat ctagttcagc 46800 ttctccctgg tgtgggctcc cttctgtggt gttccagtca gatggccatc gagtcaagac 46860 ttggccgtcg ctattctggg aaacctgaat ttggaggtga ccaattcccc cactgaacag 46920 ctttaactct tagtgcctcc tttttctttt tttttgagac agagtctcgc tctgtctccc 46980 aggctagagt gcagtggcac aatcttggct cactgcagcc tctgcctcct gggttcaagc 47040 gattctcctg cctcagcctc cctagtagct gggactacag gcgcacgcca ccacgctggc 47100 taatttttgt atttttatta gagacggggt ttcactatgt cggccaggat ggtctcgacc 47160 tcctgacctc gtgatccgcc cgcctcggcc tcccaaaatg ctgggattac aggcgtgagc 47220 gaccgcgccc ggcctttttg tttgtttgtt tgtttttttt gagacagagt cttgctctgt 47280 agcccaggct ggagtgcagt ggtacaatct cggctcactg caacctctgc ctcccggatc 47340 ccggttcaag caattctcct gcctcagcct cctgaatagc tgggattaca ggcatgtgcc 47400 accatgccca gctaattttt gcattttttt catgtttttt tagagatggg gtttcaccat 47460 tttggccagg ctggtcttga actcctgacc ttataatccg cttgccttgg tctctcaaag 47520 tgctgggatt acagtcatga gccaccatgc ccagcctctt agtgcctcct tatactgacc 47580 acagacctgc acccgtcact gctacctgct gacacgactt ctgcctttgg gaacaacccc 47640 tgtttaaacc accctcttct acctgactgc ccttcaagct ctgaagcagg gggtgcgttc 47700 ccgaggttgt tcacttattg gtagctactc tgtgcctgca gtgggctggc attctgtgta 47760 cactgtcagg tttaacctca tggaacccta caagaaaggt actgttgtaa tccccatttt 47820 acagagggga ggttgaggct cagagaggtt aagtaatggt ccaaggtcac acagtgacaa 47880 aatgacaggc ctagggattt tgcccagttt ctctgtactg tgttaaccag ctccagttcc 47940 ctctactctt cagacccctc ccgccccacc acagtcagcc gcctctggag acctgcagca 48000 gggccgtgtc cctcttacta cacagtgcct ggcggagagc acgacacccc ccgcatggcc 48060 tgtgccagtc acggtatgtg tcagaatctg gaagcatcgt tcatcattct cggaccttct 48120 gcccaagtgg tctctaggca gagtcccgca gccatcccac ctgtcagctg agcatgtgtg 48180 tgaaggtttc agggtgggtg acaaccttgc agacggtgag gtctgaggag cccacaggtt 48240 ggggaagggc agagacctgc tcaccggtgg ggaggtatct atagtagtag atgacaggat 48300 gaagaaagtt agactgccag gcatcttctg tgtgccccac agaccggtca tcaaagaaga 48360 cgtccttgtc ggggccagag aaatttctgc catattccat gttgatgacg aagagcccgt 48420 gctttgcctt cctccctgtg agtgtctcca gctgggccag catctgtatg gggaactcct 48480 ccaggtactc aaaggccgtg gaattcctgg gagaacagca acgcggggga ggccctcagt 48540 gctgtggcag aggtgagggg tgcagcccgg gggtgagcat gtgtgtgtgc gtgtgtatct 48600 ccccctctaa ggagcgtcaa tcaagcagca cacccctcac ttaacattac tttttcagct 48660 cagctctcac gcacatgtgg ggtagagacc agaaaattcc atgtaacctg aatgggatat 48720 ctggggaaag agtgtcccag gcagagagaa cagtcaggaa aaagccctga ggagtatgtg 48780 agcactttgt gttcaaggaa cagaagaggc cgacgtggct gaggggagtg aacagcaggc 48840 agagggcagg agagggggcc ggaggccttg agaggtcaag gagggctgcg cctcccatga 48900 cgagacgtga ggagtcgtct ggcccgagag gtgacactgc tggttgcttg ggaggactga 48960 gcagagctgg gatcagcatg cctcaggttt ctaaggacca ctctggttac tgtgctgaga 49020 acagacgcca ggccaagtgg ggcggctgtt gtatgggtgc aggtgataca gcctggtgat 49080 cgggaccgag gtggtggtgg tagagcaggt gagagctggt tgggctccag acatcatctg 49140 aaggcagagg tgacaagact tgcccatggt ttgcatgtgg ggtgttgaga caggggtgcc 49200 aggcgtgctg actcacgcct gtaatctcag cactttggga gaccaaggcg ggtggatcac 49260 ctgaggtcag gagtttgaga ccagcctagc caacatggtg aaacctagtc tctactaaaa 49320 atacaaaatt agccaggtgt ggtggcatgg gcctgtaatc ccagctactc gggaggctga 49380 gacacgagaa tcgcttgaac ctgggaggtg ggctgcagtg agccaagatc gcaccactgc 49440 actccagcct gggcaagaca tagtgagact ctgagtcaaa aaaaaaaatt agccaggcat 49500 ggtggtgggt gcctgtaatc ccagctactt aggaggctga ggcaggagaa gtgcttgaac 49560 ccaggaggca gatgttgcag cgagcagaga tcgcaccact gcactccagc ctggatgaca 49620 gagcgagact gtctcaagaa aaaaaaaaga ggggcagggg catggagggt gatgcgaggg 49680 ttttgtgcag aaagcggctg cactacctgc atgtccctga acttggtgtg ctatagcacg 49740 ccctgccttt ggatcgggct gttccctctg actgaaggtt gctcccttgc ttctccctgc 49800 cacctgtctc cccccgcccc tcacccctct gtgctctgca ccgtttcctt ctcaggaact 49860 gtccatcctc tgggatctgc tgcttatcac taaattgact ctgacgatgg tggccggcaa 49920 ggccctggcc tgagggagct ctgagatcca cgtggctgcc tctgactact gctcatccac 49980 gtgatgccaa acactttcca caagtgacct ttactccttc ctttactgct gcaaggtagg 50040 cacaattatc cccattttgc agatgaggaa gaagggctca gagaggctca ctaatgtgcc 50100 cgtggccact cacaggactg tctgtagagt taatgtcatt gtttttcccc agaacaggca 50160 tgttccccac agcagccttc atcttaggaa agaactgggc acctcacacc tggaatagga 50220 agagaagcgc tatgcagcac gtcgggaaag ctgggccgag gggagtaggg tggggacggg 50280 ctactcactc cttcaacagg atgacatcgg ccagcacacc gaacatctgg tagagcccag 50340 aagcctcatt cacgcgccgc acgatggagc tggtcagctg tgtgatgggg agctcagtgg 50400 cgggccaggt gacgctgtgg tggcggtgct ccaggagccg gtgaacagca cgcactggaa 50460 cagccagagg gaggaacggc acgctgcact taccatttta tctctggtca ctgggaggga 50520 tgcccaggcc tcattgaccc ctgagaacgc catacacact ggtctccatg gcccagcgca 50580 aacgcctagg tggtgaacac atgaggggag gagatggcag ctgcctttag agcagggcca 50640 gcaggtattt tctggaaagg gccagacaat ccatattctc tgctttgtgg gtcatacacg 50700 actcagtgat gctgctcaat tctgccccta gtgtaaaagc ggccaagaca acaggcaaag 50760 gagtgagcac agctggagtt ggtctccagg ccagagtcca tctgcccctg cttcaggcca 50820 tctgcacgtg ggagtcccac cggccccacc tcacacaagg aacgtcaagt ccaacacgga 50880 gccttcccca gaaacctccc ccccttcaca gctctgtttc catcagagac gcgcctacag 50940 aaatctttga tttcgccctc tctttcacag cctaaatcca tctgtctcta agttcttttt 51000 ttaaatattt tttattttat ttttttgaga cagggtctcg ctctgttgcc caggctggag 51060 tgcagtggtg cgatctcggc tcaccgcgac ctccgcctcc tgggttccag gaggaaccga 51120 ctcccagaat tgagtccaat cctttgcccg tactgtaaga cccctctgca gtggtcccta 51180 cacttattat tgtagtcctc taacctggaa taaagtccac cttaccgtct tcatttgtat 51240 tatgattttt gagacagagt ctcactctga tgcccaggct ggagcgcagt ggcacgatct 51300 tggctcactg caacctctgc ttcctggatt gaagtgattc tcctgcctca gcctcccaag 51360 tagtagggat tacaagcctg gctaattttt gtatttttag tagagatggg gtttcaccat 51420 gttggtcagg ctggtctcga acttctgacc taagctgatc tgccagcctc agcctcccaa 51480 aatgctggga ttataggcat gagccactac gcccagcctg ccttactgtc tttaaaaaga 51540 aaaaagaaat ataaatattg aatgtctttg agtggcagaa tataaagatt actccccgta 51600 attccctaca ttttcacatt tttgatgctc aggctaggca tggtggctca tgcctgtaat 51660 cccaacactt tgggaggctg aggtgggtgg atcgcttgag cttgggagtt tgagaccagc 51720 ctgggcaaca tggcgaaaac ttgtctctac cacacaaaaa taaaaacaac aaaattagct 51780 gggtgtggtg gtgcacgcct gaagtcccag ccactcagaa ggctgaggtg ggaggatggc 51840 ttgagtctgg gaagtcgagg ctgcagtgag ccgagatggc gccattgtac tccagcatgg 51900 gaaacaggaa gagacgctgt ctcaaaaaaa ataataatac taatttttta aagctcagct 51960 gtaagattat gactccattc tttcaaatag actcacctaa ccacctaact gaatactgta 52020 tgcctcactg agtgaatttc aaccaacaec ctgtccttct cagaaggtta accacaggag 52080 caggaacatc taatttttat ttatttattt atttttgaga cagagtttca ctctttttgc 52140 ccaggctgga gtgcaatggt gtgggcttgg ctcactgcaa cctccacctc caaggttcaa 52200 gtgattctct tgcctcagca tcccgagtag ttgggattac aggcgcccgc caccatgccc 52260 ggctaatttt gtattttaag tagaggtggg atttcaccat actggccagg ctggtctcga 52320 actcctgccc tcaggtgatc cacccacctc agtctaccaa agtgctggga tgacaggtgt 52380 gacccaccgt gcctggccac atctaacatt ttagactcct ctccacagaa agggcaccag 52440 tttgctttct atgaaagaag agaagacctt tgtagaaagt gtctttcagg aaagctcctg 52500 ggccttggag tttaattccc ataatggtga gaaaatcacc aaaactctga gcctcagagt 52560 tttacactct tgaggaaaat ggagatttca cacccacctt tcggggtgct ggcggccctg 52620 ccagggtcgt gtgttcagtg ctcagcccac tgaagtcacc caacatgcgt gaattcatct 52680 ctctcacttc ctttttattt cccatttact cctaaaatca caagtatcaa tttttggttg 52740 gggattattt tagtgcaata aatagaatta tgtttttaaa agatatttta gtattttctt 52800 tgtaaacatt ctcaagttgg cagaaaattt atacccttgg tactgagagt tttgaaaaag 52860 aactgatata atccaattac attttttttt ttttttttga gatggagttt tgctcttgtt 52920 gcccaggctg gagtgcaatg gtgcgatctc agctcaccgc aacctccacc tcctgggttc 52980 aagtgattct cctgcctcag cctcccgagt agctgggact gcaggcgcac gccaccacac 53040 ctggctaatt tttgtatttt tagtagagac agggtttcgc cgtgttgccc aggctggtct 53100 tgaactcctg gcctgaagca atccacctgc cttggcctcc caaagtgcta ggattacagg 53160 cgtgagccat tgcacctggc ctacacttaa ttttatttta tttttgagac caagtctcgc 53220 tctgtcaccc aggctggagt gcagtggtat catcatggct cactgcaacc ttgacttcct 53280 ggactcaagg gatcctcctg cctcagcctc ccaagtagct aggactacag gcgtggactt 53340 ttacacttta tctgatactt tcctaaacat gtcgtcagac cacaaaaacc tgttgtcact 53400 tccccaagac aatttatgac aatgagctac tgacaagcaa tcccctaatg cttctggaca 53460 taggagtaga tttataaacc ctgggatgct gagagtggtt ccgtctgggg acagttctgc 53520 cttctcagct gggctcacct gtgtatcgga atccgtggat gaagccccca gcagatttcc 53580 ggtagtccac cgagtggctg gcagtaccca ggataaacag accccggctt cctttggatt 53640 cgtagctagc tcgaatcagc gggtacttct tgccgaatgc atttcccgag ttaagtctga 53700 gggacctgtc agtggaaagg gctgttcatg aaaatagctg ctatgtaaga ggcacttatt 53760 tatttagtta gttttgagat ggagtttcgc tcttgtcgcc caggttagag tacaatggcg 53820 tgatctcggc tcactgcaac ctctgcctcc tgggttcaaa ctattatcct gcctgagcct 53880 cccgagtagc tgggattata ggctcctgcc accatgccca gctaattttt gtatttttag 53940 tagagaccag gtttcaccac gttagccagc ctggtctcga tgtcctgacc ttaggtgatc 54000 tgtctgcctt ggcctcccaa agtgctggga ttacaagcgc gagccactgc acccagccag 54060 gaggcactta ttacagtggc acttattact ggcactgagt gccttagatt tctcgtctca 54120 tttaaacctc accatgaccc caggaggtgg gtattatcat ctccatttaa gagatgaagt 54180 cggccaggcg aggtggctca cgcctgtaat cccagcactt tggtaggccg aggcgggcga 54240 gtcacaaggt caggagttcg agaccagcct ggccaacaca gtgaaaccct gtcgctatga 54300 aaaaatacaa aaagagttag ctgggggtgg tggtgcaatg gctgtaatct cagctactca 54360 ggagactgag gcaggagaat cgcttgaacc taggaggcag aggttgcagt gagccgagat 54420 tatgccattg cactccagcc tgggcaacag agtaagactc tgtctcaaac aaacaaacaa 54480 acaaacaaac aatgaagtca ggccaggcac agtggctcac gcctgtaatc ctagcacttt 54540 gggaggccga tggaaaggag ggtctggaca ggcacaccag cttctccttt gtctttctgc 54600 accctggtca gaagacaagt gaaagactgg atgctgcttt gataccaaac ctcccgaggt 54660 agtcggcagc aatgtttaaa atctaggctt cataaaatag cccttcaaaa tacaatgata 54720 aataacttaa gcaactaaca ttttattgag cacataatac atgccaagta ctttctttat 54780 tttaagagat agggtctcat tatgttgccc aggttggagt gcagcagcta ttcacaggca 54840 tgatcatagc acactgtagc cttgacctcc tgggctccag tgatcctcct gcctcagcct 54900 cctgagtagc taggtactca tcactgcacc tagctcccag cactttcttt cctttctttc 54960 tcccctctct ctccttcctt ctctcctctc tctttttttg tttttgagat ggagatcttg 55020 cactgtcgcc tgggctggag tccacaatgg cgcgatctcg gctcactgca acctccacct 55080 cccaggttca ggcgattctc ttgcctcagc ctcccgagta gctgggatta ccggcacgtg 55140 ccaccatgcc tggctaattt tttgtatttt tggtagagac ggggtttcgc tacattggtc 55200 aggctggtct tgaactccta accttgtgat ccgcccacct cagcctccca aagtgctggg 55260 attacagcat gagctactgt gaccagccat ctcttttttt ttttgagaca gggtctcact 55320 ctgttgccca ggctggaatg cagaggcatg atcttagttc accacagcct cgacctcctg 55380 ggctcaagta gtcctcccac cttggcctcc tgagtagctg ggaccacagg catgtgccaa 55440 cacacctggc taatttttgt attttttgta gaggtggggt ttcaccatgt tgtccaggct 55500 agtcttgaac tcctgagctg aagtagtatg cctgccttgg cctcccaaag tgctgggatt 55560 ataggtgtga gaccatgagc cactgcacct ggcctctgca cacattcttc tttctttttt 55620 tttttttttg agataagagt ctcgtcaccc aggctggagt gcagtggtgt gatctcggct 55680 cactgcaact tctgcttccc aggttccagc aattctccca cctcagcctc ctgagtagct 55740 gggattacag gcacccacca ccacgcttgg ttaaattttt gtatttttag tagagatggg 55800 gtttcaccat gttggccagg ctggtctcga actcctaacc tcaagtgatc cacctgtctc 55860 ggcctcccta agtgctggga ttacaggtgt gagccaccgc acccagcctc caagcatatt 55920 cttatgttaa tcctcgcaat aaccatatga gaaacaaact ttgaatccca ttttagacat 55980 gagaatactg ggccacagcg tggttaaata acttccgccg aggtcacaga tttggcaagc 56040 agagaatctc aggacaattc cggcacctgt gctctcagcc actacgctat attgccttcg 56100 agcaaattcc cctctgtatt ctctctgagc cggcctttcc aactcacagg tggaggctcc 56160 caatgctgat gaagatctgc tggtgttgct ccaggaccaa gggcctcagg gccacctggg 56220 accctcaatg gtcagagctc atgtcctgga gggaaatcag gcagcactca catccattct 56280 ttgggtgctg tcctgagagc tctgtcgcca gcctactgaa cagccaccct gttcccctag 56340 ggaggggtca ggagggtttg ctaggagagc ccacctcctt ccgcatggaa ctcacttatt 56400 gaaaatggag aagtcaaagt tccagcccag gcagcggatt acccggtcat agggcacgcg 56460 catggcaaag ttgtcattgt cgtcctgggg gagggtgatg gagtcggcac tctggttggt 56520 gttggcttct tccaggaaga atttcggggt gacatggaac ttgcctttgc tgtccttcag 56580 gatggccaga tccgtcaggt cagactcgag cagcccgtcc agggacttga gctggtaggt 56640 atccagcagg ccattgttga tggctctgag cccacagaga atgcagggga gagagactca 56700 gaggaaagct gggcagtgca gctggggtca ggaagggcag gggagggttg gggaggctct 56760 ttccacactc tgggctccca gcacagaaca cacatgcggg gatgtggcct acctgaggtc 56820 tccaacgtag tgggtggccc aggacagacg gacccgggag cggctgagca tatggataaa 56880 gtttgtgaca cccaagatgt tctctgctgt ctcaaaggcc gagttcccac gacccaggat 56940 cagcacattc tggcctacaa agtcctcagg gtccacggac acggactcgt aaccctctgc 57000 atattcggag ccagggaagt caacctggtt ggggactgat aaaccagtgg ctacaaagag 57060 gacgctgcag gcggggacag aggaaagatg gcttagtctc ttagctataa gaccactaag 57120 tgaaaaccac tccctggacc cacccaccca cctgcctggc tccaaccgcc ggcccctaaa 57180 agaaaatagg acattcattc attcattttt cattcattca tctgtttacg ccctcatccc 57240 agtgcacttg agaggctctg cccttgcctc tccctgagct cacagtattt tccctagcac 57300 tgtactgggg gttaaatttg ccctgtgaga gaggagaaga tgacagtatg agaaatggag 57360 aattcaccta actttgcaca tagcagtcag accaggtatg actgctggtg atgaaatgaa 57420 acctgacatt ctactttccc ctttctgagt cctctgacag atacatctat ccactgagca 57480 gtaattctgt accaggccct gtactaagtg tatctgtgca ccatctttct gactcctcca 57540 agcaacctgg aggtggtatg tggcctgctt tacaggtgag gaggcacagg ccctgcaggc 57600 ccatggcttg agagctccta aaagcagcag agccagagtc taaacacaga taggcttgat 57660 tccaaagtcc tgctccttcc attggtgagg atcgccatcc aggggagggc agctggggac 57720 ttggatcctg ccggcttgca gaagaatgct ttgatcacag agtggtttca aaaatagaat 57780 tgaaggccgg gtgcggtggc tcatacctgt aatcccagca tttggggagg ctgaggtggg 57840 tggatctcct gaggtcagga gttcgagacc agcctggcca acgtcgtgaa atctcatctc 57900 caccaaaaat ataaaaaaat tagccgggtg tggtggtgct tgcctgtaat cccagctact 57960 ggggaggctg aggcaggaga atcgcttgaa ctagagaggc ggaggttgca gtgagctgac 58020 ctcgtgccat tgcactccag cctgggcgac agagtgagac tccgtcttaa aaaaaaaaaa 58080 aagcgaaata ccctttttcg tccattcctc ccatacctac tggccaatca aggtgtgtgg 58140 ttcgtgtggg gaaggtccca gcttccgcag gtgagctctg gcaccggcct tacctgcact 58200 gatgcacctg gcccttctgg tcagttagga tgaagtagtg gccattccag gcctgtcggt 58260 ccttgtccag agtgacgtgg gcgatggtgg tgttgtactg gacacggagc cccagcgtgt 58320 ccgcgaagtc acccaggtag cgcaccatgt cgcgggcgtc ggggaagtag gcacgcgagt 58380 agtgtctgaa gagcagccgg gggtcgtggc tgagcagaga gttccagtcg tggcggaggt 58440 tgaactcggc gttagccttg cccgtgtacc gcttgttgat gctgatgagc ttgcggtgcc 58500 gcgggtagcg tgtgaagaag ctgccgggcc gcggggcccg ctcgaacact gcgtagtcgc 58560 gtccagcgcg ctgcaggaag taggccatct gcaggcccgc gggcccagcg cccagcacgc 58620 agtagtcccg gcgcgggggc accgacagcg ctgggtgcag ggcgatggcc aggagcagcc 58680 ccgggggacc ccacaacggg gccgcagcgg agaggcccat cctgcagcag atcagagggg 58740 taaggcctcg cacccggccc ggcggctggg agacacgagg cccagaaaga ggcggggcct 58800 gcgggaactc tcactgcaat ctgggtcacg gccaggccca gaagccgtcc tcagagctca 58860 tttgcccgga ctccaccgtt tcaagctggg acttggggct ccccggaatc ccgagcccct 58920 ccatcttatc tccctcaggg tctccttcct caggggcacc ggctccccgc ttatgattgt 58980 agtaacctcc accctgggga aggagagcgt actccccaat tttcccctaa tttgagggtg 59040 cccaacaccc ctttgaacca ccctccaggt tggaccttcc agaggccttg gcccctctcc 59100 agcgaccggg tgggagcctg aagtgggtgt ggcctgcgtg cgccccgccc cctgccaggg 59160 tccgcgcgcc ccaggctctt cggccacgtg acagggatgc cgcgcacacc tgccgcccgc 59220 ccgcgtgcgc ttcaggagcc gccaggtccc tacgcccgca gctccggcct ccccgcctcc 59280 gaccgaaccc tgagaaacgc gcgaacctcc cagccgctcc ggctgcaacc cgtggtctaa 59340 tgaggccgcg cttggctcgc ttgctccgcg gcggctccgc ccctcgcgcc cggaccaatg 59400 gcagggggcg gggtcacgtg cgcggcgcgc ggcacgccgg gaccagctgg caggctgcct 59460 gctccggccc agcgcgggag aggcgcgcgc gtgctgcgtt cgctgctccg ggggctggta 59520 gaggggcctg gggctagcgc gcacccgcga gggtggaagg tctggagatc cgggatgggg 59580 aactgggtcc ttcgttttaa aaggtgcctc tctacacgga gggaggggag cacgtgattt 59640 ttggagctaa tcctagctct catattccat gaatgtagcc aaacgctaaa actagttggc 59700 ctacccagtt ttgtgggact ggaaaccagc gtggtggagc caggaccgat aagccaatta 59760 acaagcgttt gctacagtga ctcagtgtac tgcttaccaa gtaacataca cgactgtcct 59820 aatcttccac caaataggag aggtgggcaa ggcattgttt ccgacatttg gtagctgact 59880 ggtcaaatgg agacataggg atgaagggat atgtttacaa tcacaggaag tggagcctgg 59940 aattaaaact cagtggaggc aagataaatg gcaggaggaa gataacgtga actggatgat 60000 gaaggttggc ttcccagggg tggcaagtgg cccctgcatg agatttacat ggggagaaat 60060 acgaagtcag tgtaggaacc ttcaaagtcc agtgaaatgg ggctgagtgt tcttggggga 60120 agggcaggtg gaaagaactg cgagcctgca gatttgcatg gctggagatt ctttgaatta 60180 aaaatcgtag ctggggactc cttagaaaaa ttttcctgac ctctcaggcc tacaagtacc 60240 taccaaagaa tgtcatttac tttttctttt tttttttttt ttgagatgga gtctcactct 60300 gtcgcccagg ctggagtgca gtggcgtgat ctcggctcac tgcaagctcc acctcccagg 60360 ttcacgccat ttttctgccc cagcctccct agtagctggg actacaggtg cccgccacca 60420 cacccggcta attttttgta tttttagtag agacagggtt tcactgtgtt agccaggatg 60480 gtctcgatct cctgacctcg tgatccgccc gcctcggcct cccaaagtgc tgggattaca 60540 ggcgtgagcc accgcgcctg gccgaatgtc atttactttc ttcagtctgt gtcaacatca 60600 gagaaaagct ccctcagagc agaaattgtc cagtatctga catacggaag tttaagcatt 60660 tgttgaataa gcattgcaac cagagaggtc aggcagaata ctttgccaaa aataaagtag 60720 ggatgtctta tttcttcttt ttgagacaga gtctcactgt cacccaggct ggagtgcagt 60780 gacacaatca tggctcactg cagccctgac cttccaggct caagcgatcc tgcttcagcc 60840 tcccaaagtg ctagggatta caagtgtgtg ccatggcccc tggccaattt ttcaaaaaaa 60900 tttttggggg catatgtgta tatatttatg gggcatatga gatgttttga tagtcatgca 60960 atttggggat gtctgtttct tagtggttgt gaagattatg agaatgggtg ctggcaaaca 61020 agttcctaaa ataattgctg gtcttatgtg gtgaatacag tagtgggaaa ttaaacagaa 61080 ttcgtcaagt atggtagggc cctacgagta ggctgaacct agattgtaag caacaggatg 61140 ctactgggag tttctgaatg taggattact gcagcagtca acttggtagc cccatgcagg 61200 acagataaaa gcagtggaca gctactcggg aggctgaggc aggagaatgg cgtgaaccca 61260 ggaggcggag cttacagtgc ctgagattgc gccactgcac tccagcctgg gcaacagagc 61320 aagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaaaggc agtggaaact gatgcaaagt 61380 attttcaggg aatgagcttg agtcacttcc acttgcttct gttaatcctg ttggacaggg 61440 ccatggtttg caagaggcaa tttggtgaat actggtccaa cctggaaacc cccggcacta 61500 gtcacaccac tttaatctgt tttttaacac tctgtattca cattgaaaac tccccaagta 61560 cactttttct ctccactgct tctaacacag ttcaagaaac cttttgcttg ctgaggttcg 61620 attcattaaa attaattttg tgttttttca agctacttta aaaaaaaaac ctgtaacttt 61680 agaaatgctg agcttttttt gagagtctct gtaatccaaa ttggagtgca gtggtgtgat 61740 CtCagttC3C tgCaaCCtCC gCCtCCtggg ttCgagtgaa tCtCCagCCt CagCCt .CCCa 6180 agtagctgga attacaggcg tgtgccacca tgcctggctg ttttgtattt ttagtagaga 61860 cggggttttg ctatgttgct caggctggtt ttgaactcct gacctcaagt gatccaccca 61920 cctcggcctc ccaaagtgct gggattacag gcatgagcca ctgcacctgg cctttttttt 61980 tttgataaag ggtctccttc tgtcacttag gctggagtgc agtggtgtga tcatagctca 62040 ctgcagcctt gaactcctgg gctcaagcaa tcctcccacc tcagcctcct gagtagctgg 62100 gaccacaggt ggaagcatca tgactggcta ataatttatt tttttgcaga gacaggccct 62160 ggtctccctg tgttgcccag gctggtctca aacttctagg ctaaagtgat ccttctgcct 62220 cagcctctca aagtgttggg attagaggtt tgagccacca tgcctgtttc ctcacctcta 62280 caatggtact actcctgcca gcatcacagt tctgtatgag gcttagatac tacagaaagc 62340 tcagcattaa tacctggcag ggtaattact ccatcaagtg tccagaacag aacagtgtcc 62400 acttacatag tttacatagc ctcggctggg tgcggtggct cacgcctgta atctcagcac 62460 tttgggaggc caaggcgggt agatcacctg aggtcaggag ttcgagacca tcctgaccca 62520 tatggcgaaa ccccgtctct actaaaaata caaaaattag ccaggcatgg tggtgcatgc 62580 ctgtaatccc agctactggg gggctgaggc aggaggatcg cttgaacctg ggaggtggag 62640 gttgcagtga gccgagatca tgctactgca ctccagcctg ggcaacaaag tgagattccg 62700 tctcaaaaaa aaaaaaaaaa aaaaaaaaag tttacatatc ctcaacatgc agagctctta 62760 tgacacaatg ctttgtaggg acaggcctga gtgtcaccag cccaagccaa gcttaaaaac 62820 aattcataaa ccattacaca atcacccagt gggacatcca tcaagctctc tgtggcagcc 62880 tccctcaggc gcagcagccc cacctcaccc acaccctgct tcacgctgta ctagtgctct 62940 gcactccagc tcctcacagt gaactctcca aaagcaacag gtggcccttc acacagccag 63000 caggcactca tgcttgtgga aatggacttc ttataacaaa tgaggacacc cagattctga 63060 attccacata gaaattgctg aatetcatcc ccactctgtc aggaatcttt gaagaaacga 63120 ctgtaaatcg ttaatgcagg cagacgatga gggaaagact aaacagatat atattttatt 63180 tcatctgcta aatgtcagag agcaagttag acacacattc cactaagcat caaaggccct 63240 cgtagtctcg gtggaaggac aaactccagc tccacatcac tggtttaagt ttcttcctct 63300 gaaagacaca aaaaatgtaa gagaaatgag ccaggttgtg tgatatgatg ttcactttcc 63360 tttctgaacc tctgctggac tgtgcgtgag ttttcaacac ttccattccg aagttaagcc 63420 tttcagatgc tcacagggct gggcaggtat ttccttcagt caccagctgg tggagcagga 63480 gagacaactt tcaggctatt taacccggag cggagctttt ccctctagac caccggcttc 63540 aatctgggac ttccctcatc ttcctctacc tctgccacag tccagccgct tctctaaaac 63600 accgctatcc tccccaacca cttgatgtga tctaaaggct ctagaagaag ctcttggagc 63660 caaagtgaat gcttcttcat acttaagtct cagggaattc tcgaagtttt atcaaggtta 63720 aagatcacaa tggctacaga gcttgctccc gtgctagccc acagatcact ctagacctca 63780 gaaagtgggc tgctacacac cttcttcttc ctcttcttcc tcctcctctt cctcctcatc 63840 ttcatcagag ctgaaggtgc catcagggag gctgtagaca cggatgacct gcttgttggg 63900 gtccttgagg atgaggtatt tgccctcctc cagcttcatg cagatgtcaa tgacgcagcg 63960 taaaatgccc caggcattct ccacgctcag gttgatctgg ctggcaaact cattaggctt 64020 gaactgctgg gtgcctagga tgacgtggcg tgaggagtct ttcacgtggt accgagacac 64080 ataactaaca ggggaaggga tatcagtggt cagagcaggg cagcacagag acagcaacac 64140 ttgggatcaa atgtcaatta aatggtgata cctggtccac tgctattttt tctttttttt 64200 ttttttgaga cggagtctgg ctctgttgcc caggctggag tgcagtggcg ccatcttggc 64260 tcactgcaag ctccgcctcc cgggttcaca ccattctcct gcctcagccc cctgagtagc 64320 tggggctaca ggcgcccgcc actacgcccg gctaattttt tgtattttta gttgagacag 64380 ggtttcatcg tgttagccag gatggtcttg atctcctgac ctcgtgatct gccagcctgg 64440 gcctcccaaa gtgctaggat tacaggcatg agccaccgcg cccggcagtc cactgctatt 64500 ttcaagggaa agggaaaaca tcgtcttctg agttctcagt tctggatttc attgacacca 64560 ttgccctagt tcaggactcc attcagcatg cctgctgttt ggcatttgtc tcctaactga 64620 cccctccatc tctaccccac ccctggattt atctctgcca gtcaattgtc cagtacacgg 64680 ggaggggagg gtcaacctcc ctacccagac ccttcctttc acaagatcag ctgccagctc 64740 ctgcacagga atctcaccca agcttgaggt actcagatcc agccagcaaa gcacagcagg 64800 tccaccgggc caacttgtag ctgttgttct tcagctccgt ggcaatgaca gcccctcgct 64860 gagagtccag cttctgacgc cagtcaacgc cattacagtg ctgcaggaga gccccgttag 64920 agaaacagaa gcaagctcca aatgcccaag gtgctgggac ctcctctggc agagaaggaa 64980 ctccctagtc tgcttgctta gaaagtgggt aggtacgcac taaatcttac catttaagag 65040 acaaagacat agtcccttcc cttgcacagc ctgccgcaca gcagtcactc aacgacttac 65100 aattcctctc ttctaaaagc tcgcctagac agggaatgat ggatggacac acacggacac 65160 acacacacac acacacactt tagaagtgtc atataaacag cagagccaag tgtttactat 65220 gtgttgcgtg gtaaggaagg gcttcacaga ggacgtgtaa cagtgagcca agtggagaat 65280 attggctcaa gtgcaggtgt agccaggagg tcttgatctg agaggcatgg tgggatagga 65340 aagacaggca gagttggcct tagatggggg tggaagcctg cagtgggtgc aaagctgagt 65400 ctgacatttt acataaatgc acacacagta gaaaaggacc ccagagagat cctcttttct 65460 acccatatca tttgtagacg tgggaagttg gacccagagt gaaatgactg gtcaaaggtc 65520 acatgacaga ggttcccaaa ctttcttggt tcatggcaaa cacagggcaa aagaaatact 65580 caagaatttc ttttaaattt tttttctttt tttttttgag acggagtttt gctcttgttg 65640 cccagggtgg agtgcagtgg cacgatcttg gctcactgca acctccgcct cccgggttca 65700 agtgattctc ctacctcagc ctccctagta gttgggatta caggtgcccg ccaccatgtc 65760 cagccaattt ttgtattttt ggtagatacg gggtttcatc atgttggcca ggctggtctc 65820 gaactcctga cctcaggtga tccactcgcc ccggcctccc aaagtgctgg gattacaggc 65880 gtgagccacc gtgcccggcc aagaattcct tttatttagt tagggtcaaa ccatgtatta 65940 gtattctgac aagatgtctc tgtgtttccc taaaaaattt aaaatatcct gcagcactcc 66000 tgtgagtttg ctgtggcaca ttttttggag atggggtctc actatgttgc ccaagctggt 66060 gagttcagga tttgaactca tgaacccaag cgattctccc acctcaggct cctgagtagc 66120 taggactata ggtgcatact actgcataca gcttgctggg gcatgttaga attcttctcc 66180 caatctgcac tgctgatgaa gcgtgtattg gacaattgac tggcggagat aaatcaaata 66240 tagaagttgg gtggaggtag agaaatcagt taggagacaa atgtcaaaca ggcatgatga 66300 aatggggccc tgaactaggg caattatcag tgaaatccag gacagattca gaagacagca 66360 aagccttcta ttttgctaac agcaaaacag aataatgtaa aaaagaagtt ggagatgttg 66420 gaggctcaga gcttaggtgg aagaaagaca atgctgatgg acagctggcc cagaggcaat 66480 gacgggactg gggacacatg gaaggggaag gtgttttagc agaaaaacaa tgggaagtat 66540 aataaatcag agtagatttg agaaatcatt ttcaaagagt tcatggttga ggcctgggat 66600 gggcagaatt ctaagatgac ccccagtgac ccttgccctt gcagagtctc ctccccttga 66660 ctacgggcag aacctatggc taggatcaag tatcaccccc atgatcatcc taccttgtat 66720 gtcaaaaggg attttgcaga tgtaaggccg caaatcagtt taccttaata tacactacct 66780 ggctgggctc acccaaccgt atgagtctct taaatctagg tgtagaggtc ggagacggag 66840 gaagtcagag atctgaagca caagaaggat ctgatgtgct gttgctatct tggagatgga 66900 gggggccatg tgacaaggaa tgcaggtggc ctctaggagc caagagaggc tcccagctga 66960 caactggcag ggggatgggg gcctcagtca tctaactgca gggaaatgaa ctttacccac 67020 aataagaatg ggcttggaag tggcttttct ttcagaacct ccagatgaga actcagttct 67080 atttctattg acaccatgat ttctgccttg tttggatttg tggccccacc caaactgcat 67140 gtcaaattgt aaactccaat gttggaggag gagcatggtg ggaggtgact ggatcatggg 67200 ggcagacttc cccctttggc actattcttg tggtaagagt attcaagaga tctggttgtt 67260 taaaagtgta taccaacctc ccccctctct ttctcctgct ctggccatga tgtgcctgct 67320 tctcctttgc tttctgccac cattgcaagt ttcctgaggt ctcctcagcc acgcttcctc 67380 tagagcctgc agaactgtga gccaattaaa cctcttttct ttataaatca cccactctca 67440 ggcatttctt tacagcagtg tgacaatgga ctaatacaag gaccaagcac acagcactgg 67500 acttctaacc tacaaaaccg tgagctaata aattggtatt gttaggccgg gtgctgtggc 67560 tcacgcctgt aatcccagca ctttgggagg ccgaggcagg cagatcacct gaggccggga 67620 cttcaagacc agtctgacca acatggagaa accccatctc tactaaaaat acaaaattag 67680 ctgggtgtgg tggtgcatgc ctataatcct agctactcgg gaggctgagg caggagaatc 67740 gcttgagccc gggaggtaga ggttgcagtg agccgagatc gcaccgttgc actccagcct 67800 gggcaacaag agcgaaactc cgtttcagaa aaataaaata aaaaataaaa gtaaaataca 67860 taaatcggta ttaagtcatt aagtttctgt taatttgtta tggtgcgaaa gaaaactaat 67920 acaaagttat ataatacaga agtatgtatg gcgaagagag ctgtccaggt gactccactg 67980 ggatcaaaaa ggaggggagc cagcaaagac gacatgcaaa cggaacaggg aaacgggtga 68040 gaccagagta acgcggtaac acagacggca aaacgacaca ggcacgacgg ccctgaatgc 68100 tttggggagc tcaccaggaa aaatccaaga aaaggccgct ggccccagag cggcaaacct 68160 tccagtgtgc tctttcaaca ggtgatgtgg gcgggggggc ggattgggag gggtggggtg 68220 gaaatagagg aggaaaagtg aaggaagcat gtttctttca aggtgcctct gaagagtcaa 68280 ttctgagcca gatcttagaa tccatgagtt aaagaaatga ggaattgcaa aaaatgtgtg 68340 aaaagattga aggcagtggc tcagtcaatg aaagaagagg tcaaaaagaa gagcggccag 68400 acttacagga aaactgccaa cccagataat aaggagagga aaaaatcaga tgctcaggga 68460 gcagaagtca acaggaggcc acaatggaac agagatgaag aaagtactgg aagaagggag 68520 ttaactggtt cctgcgtaaa aaataagcag aaaagttctt aacacttaac atagttctac 68580 acacacagtc atgctctttc tcagcaagga actaagcaga ggaaaaaact cacaagacaa 68640 aaaaaaacat ccaggtagct ctataagtaa cgaaagggga taagaaacag tttatacaac 68700 ctagcctgcg taaacaggca ctgtagggaa tagagacatg gtgtcaccag gagggtgatg 68760 gagatggcgg ctcaccctgg aatcccactc attgagtgtc ttgatgttga tgaaggacac 68820 ttccccgttg gctccagtca tgacgccatc gtgctcacaa cggacaataa ggtcaatatc 68880 atctccaagc ttccacctgc ggtaactgca gcaaaaaaga aactcatgtg gtcactgggg 68940 attctataga gtggggcccg tgctccagtc tggccacaat acccaccaga gaggtgacct 69000 accggtacgc aacagaggcg atttcattct tatccatgtc gtcctccaca aacgggtttg 69060 ggttggggaa gttgtatctt tccttcccct gcaaaaacaa aggtgtcaca agacagagct 69120 aactttgttg acaaggccaa ggccaatcag tcagacccag cacctctgct tagttgcagc 69180 cctggccagg ttcctggggc ccttgatggg gctctgagct cgctgcctgt tttgtgccta 69240 cttgacccct cccaactgtt agcacctgat gaattagaac aatgacttag taaccatgct 69300 catctctact tcattttttt gccatggcat atattcacca tttgatgtaa atcaatttat 69360 tatttattgt tcactgtgtt tcctcctcca ctatcattaa attctgtaag ggcaggaact 69420 ttgttcaaag tcagagagcc taacatccaa gcccaggcat gtaactcccc tgctaaaggt 69480 ggggactgcg tctgacctgc tcagtcccac aaccaagagc ctagcacaaa gcagatgctc 69540 cacaaacagc agctgattaa ataagaatga atcaatgccc agagactcgt ttcctcacca 69600 ttctcaagca ctgctgggag aaattgtggt tgatgtaggt tgcctccatg gccaggttgc 69660 ggggtgaatt gaaggaatta ccttcatctt gagggggctc attggcagtc tcactcactg 69720 tcaggaggtc tgcaaaagcg tggcatggtc actcaccatg caacaaagag tcactgacaa 69780 tgtgcgcagc gctgtgggga gatgtggaga ggcaaacaac acaagtcctt ccttcaaaga 69840 actgccctct cctaaagtgg gtctccctgg tgtggaacac ataagcgggg gagtggggca 69900 gctgctccag gataactcaa gatactgtcc aacattcaat tcaatcacac agtaacgaag 69960 ctgtcccttt tcagtcgttt tggattcctc aagagaatga ttttgcaagc tttttaataa 70020 agacctcagg cttcaggctc agaatataaa cacttttttt tttgagatgg agtcttgctc 70080 tgtcacccag gttggagtgc agtggtgtgt ccacggctca ctgcaacctc tgcctcctgg 70140 gttcaagcga ttctcctgcc tcagcctcct aagtagctgg gattacatgt gtccaccacc 70200 acacctggct aatttttgta tttttagtag agactgggtt tcaccatgtt ggccaggctt 70260 ggtctcgatc tcctgatgtc aagtgattct ccgcctcggc ctcccaaagt ggcaggatta 70320 caggttgtga gccaccgtgt ccagcctgtt ttgttaattt ttgagtgaca tggttttcct 70380 ttatggtgta taaatacata tatgtatggt ataaaaaata tatatgtata tacagtaagc 70440 aaacactgaa caaggtatgc aagatggcaa aagtcgaaaa aggggtattt aaatgaataa 70500 catttgggcc aggtgtgttg gctcacacct ctaatcgcag cactttggga ggccaaggct 70560 gatggatcac ttgaggccag gagttcgaga ccagcctcgc caacatggtg aaaccgtctc 70620 tactaaaaat atagaaagta gccaggcgta atggcacatg cctgtaatcc cagctattcg 70680 ggaggctgag gcagaagaat cacttgaatg tgggaggcag acgctgcagt gagccaagac 70740 tgcgccactg cactccagcc tgggtgacag agtgagactc tctgtctcaa ttaaaaaaaa 70800 aaaaaaacaa caaaaaagca acatttggaa gcttgctatt agggtgctgt gaggactcca 70860 aaagctgagg cctcaagcag gtactgcagt gacagtctct tctcctaacc tctaaagagt 70920 gtgggagatt cagacactgc tgctgtcaat tcccttggga agacagacca ctttctatcc 70980 attctctagt accagagact tgttctgtac caacaaaaat actcaatgcc tttgagttgc 71040 tccccaggca cgcttcttac caaagtcaga gttgtctctc ttgtcaaaga agagtttgga 71100 cccaactctc tggacgacaa tatcccagga atacactgag cgggtacagc tcatcagcgt 71160 ggccaggatg gcatcagtgg caaacacatt cccctgagtt tttgccagct gcaaagagga 71220 tcaaagagag aagatggaaa gacactccca ggtctcactg cccactcaca tggatgggaa 71280 agaactcctt tgctgaccac ataaatcctt aataaggagg ccccacctca ttgaccaaaa 71340 acactgcagc cagtgagcca gcaagtttcg ggtggcagtg gcactgcagc accctaagca 71400 cctgctagat tccagccaag tgcttcagat gctttcacct ttgccccagt ggtagtgcta 71460 tgtacatcta ccccttgttg cagatgagag aactaaggct ccagagacta agccaggaag 71520 cgcggcagaa ctgggcttca agtccagctg tgcttaacat ccacatttcc ggtctacctg 71580 gcaaagtgct tttacctata atacatacgt tattcccatlg tcttctgttc tttctgcagc 71640 ttcagctgta gaagccgaca gcattcctaa caagggggag aggggcagaa ggaggcgcac 71700 accttgcgga tgacagggtc gtctgtggtg gtgacagtgt ggaagatgcg cttgatgctc 71760 cgcagtggct tctcactcct cgtggtgatg cggtcaaagg ctttgtcgta gtattctagg 71820 gccccacaac actcactgtg ggaagagcag gcaaagacat gcaaagtaag agagataacc 71880 cccagttttt tcttttaagc catacatcca gaagtcttat ccaaaagtct aaaagaggtg 71940 gaaagcaatc tctggccaga gcaggagaga cgaatcctca gtgcttgctc agttcctgtc 72000 cacttaacac ctggcataga acacagcaag cacaactcat ctagcccaac gcccccattt 72060 taaaggtagg gtgaccgagg ctaagacagg agatgactag ttatagaagc acctgggtag 72120 gctgacttct cgtctggtgc tctggtttcc cactacctaa attccaccta cttgtccttt 72180 gaggtaagaa gctatttgaa atgtcaggag aagcaaagat tcctcctgaa gaattgctgt 72240 gtttcttttc ctgacaagag ttttataact taatcttatt gctcttttgc tcaggatgcc 72300 aggaaacaga aatatacagt ttaataatca gcaaattcca ttctgctttc tctttctgcc 72360 aaaagagttg tataactcat ttcttctttc ctcaggatac caggaagtta aaaagaagtt 72420 tgcagtcagt gaacttctgc ttttcccctt ggtcttgatt tttttttttt tgagatggag 72480 tttcgctctt gttgcccagg ctggagtgca atggcaagat ctcagctcac tgcaacctcc 72540 acctccaggg tttaagtgat tctcgtgcct cagcctcctg agtagctggg attacaggtg 72600 tgtgccacca cacccggcta agtttttgta tttttagtag agactgggtt tcaccatgtt 72660 ggccaggctg gtcttgaact cctgacctca ggtgacccac tgcacctggc cggtcttgat 72720 ttttttcaaa tacctctgtt aaccttatga aatgtgtttt gagtaagtgg cttcaaagcc 72780 tttttggaaa tactagggct taagaaaata cccatcacca gctggtccac acacataaga 72840 gcagtgtaga aagtagtaaa agatgctgct tacatgtcct gtggctctga tacttccaag 72900 tagcgcatct tcatcaactg aggaaaatcc atttcctctt tcacttccca atcactacga 72960 acttcaactg aagagtctcg gggtttctgc agttgaaaac cattagagga aaaaaaagtt 73020 atagtccata caaaacataa ataaaagaca ggctaaaaat atgaagagct ggcctggtgc 73080 agtggctcat gcctgtagtc ccagcacttt gggaagctgg ggcaggatga ttgcttgagc 73140 ccaggagttt gaggctgcag tgagctatga ttgcactact gcactccagc ctgagtgaca 73200 cgagatcctg tctcaaacaa caaccacata aaacggaggg gctcagtggc cctttgggag 73260 gccaaggcgg gcagatcacc tgaggtcagg agttcgagac cagcctgtcc aacatggtga 73320 aaccccatct ctactaaaaa tacaaaaatt agccaggcat ggtgatgcat gcctgtaatc 73380 ccagctactc gggaggctga ggcaggagaa cagcttgaat ctgggaggcg gaggttgcag 73440 tgagctgaga tagcaccact gcactccagc ctgggtgaca gagcaagact gcgtctcaat 73500 aaaagagaga aaagaaaaag agcttttatt caataaatgg agtgctgact gttttataag 73560 acagaatccc tgactcccag gaatttatgg tgtggaagag gaccaaaggg atcaaaagtt 73620 caaaagcaaa tggggttcca ctcccaggta atgatgtcac ctgatgaaca tgtagaaggt 73680 cctttatatt tctctcgggt tattaactat tcttgataca gcatcatatc caacaaaatg 73740 tagcttcact tttgcttaca tgtgttctgt tctcagaatg cccacacaag cacacgcagg 73800 tgaacgttca cagcagcatc aataatagtc aaaaagtgaa aaacaactca aatgttcatc 73860 agcatgtgaa tggctcaaaa caacatgatg tataattcaa aggactctta tttggcaata 73920 aacaagaaaa gaagctcatc tgggctgggt gtggtgcctc acgcctgtaa tcccagcact 73980 ttgggaggct gaggtgggtg gatcatctga ggtcaggagt ttgaaaccag ccgggccaac 74040 atggtaaaac cctgtctcta caaaacatat gaaaaaaaaa aaaaaaaagc cagacatgtt 74100 ggcacgtgcc tgtaatccta gctacctggg aggctgaggt gtgagaatca ctttaacccg 74160 ggaggcggag gttgcagtga gccaagatcg cgccactggc actgcagctt gggtgacaga 74220 gtgagattcc atcttaaaaa aacaaaaaac aaaaaccaaa aaaaccaaca acagatgaag 74280 cacagctgaa cttgaacaac atgggtttga agtacatggg tctacttaat atgcagattt 74340 tcttcaaaca aacatggatt gaaaatacaa gccaggcgca gtggctcatg gctgtaaccc 74400 cagcactttg ggaggctgag gtgggtggac tgcttgagct caggagtttg agaccagcct 74460 ggggaacatg gcagaacccc ctatctacag aaaatacaaa aattagccag gcgtggtggt 74520 gcatgcctat agtctcagct actcagaagg ctgaggtagg aggatcactt gaacccagca 74580 ggcagaggtt gcagttggct aagattcatg ccactgcact ccagcctggg tgacagagca 74640 agactctgtc tcaaaaaaga aaagaaaaag aaaacagtat tcttgggatg caaaccccga 74700 gtatatggag ggccgacttt tcatatatgt ggctaccaca ggccgaatgt gggacttgag 74760 aatgtgtaga ctttcatata ctgaaggaaa actgtaccga cacatgctac cacatggatg 74820 actcttgaaa acacgctaaa taaaagctgc cagttactaa agaccacata ttgtatgatt 74880 ccatttatgt aaaatgtcta gaacaaaaaa tcccgagaca gaaaacagat tcatagctgc 74940 ctactgctgg gctactgggg gtgctggtgt ttgggtgtgc ctcctggaat tcatttggca 75000 atctggttgc tactgcggca gtgtcgggag gtagggcctt taagagatta ggtcgttaaa 75060 aggaataaat gcctcatgcc cttctctcag gaatgggcta actacccaaa gtttagccct 75120 tttctctgtt gcaccctgct cccgcttctg ctttttctgc catgctatca agcagcatga 75180 ggccctcacc agatgtggct cctgatctgg gacttcccag tccccagaac catgagctaa 75240 agaaaccgct ttataactta cccactctca ggtattctgt tctagcaacg gaaaacagat 75300 caagacaggg tgactgctaa agggtaaggg attcttttga gggtgatgaa aatggtctga 75360 aattgaccag ttacagaact cttcaaatat attaaaaacc actaaattgt acggtatgtg 75420 aagtatatct catctaagct attaataaag acaaccaaat aaacagaacc aaattccaag 75480 gcagaattct ggtataaata cattacctgt gatttctgat cccatttctg cctaacccca 75540 aattgtttct ggaacttttt ctgcagtcga atgcgttctc tggaaagaca gacatatgat 75600 ctcagtgcag acctttaaac cagtggcttc ttcaaaaggc acacgctgcc attctcttca 75660 gctaaacctt accatcacca ctaactcctt taaactacga aaaatgggct tagagaaagg 75720 aagagaccca gacggtgcat actggaggtg ttagaaaagg tacactgcct ccaaatactg 75780 accagatgat tttacttcat ctatagtgac tgttcactga tagttccaat ctggggtgta 75840 gtggccgctg gaccacacaa caccaggagg ctcaaaggac cagcatacag ggggcttcct 75900 agagttgacc cacagcagaa ctgagcccag gtaagctcca gagcctcttc ttgcctgcct 75960 gtgtttccct ttagtgcgca tgaccagcac aaggagttag tttcctgccc atgctatctg 76020 ccatgaacca gcctgagaac gacaagctaa aagggggctt aactggttgt agaaagtatt 76080 ttcctttttt gcagtggtgg ggaatacaac catcctcctg ctttggtcct gtggtttcca 76140 aatacggcca gtctgggaag ggtgtcttgt tccagcagga tgaaaatctc acctctcttt 76200 ctgtttggca ctcttaggca ggatctgcag gttgaactgc aacatgttcc gacgatcttt 76260 gtctctgcgg aggttcctct gggcatcagc aagaaacatc catgttaaaa tcttggagat 76320 ttggctcaca ataggcagaa caagtgggag gtctttggag taaatttagg atgccaaatc 76380 ccaagtttca catcttactc tgtgctttca ctctacggca tcaacagctt gggggtgtt,a 76440 gggggtaagt g~cttggactt tgcttagacc tatactccca tgatatattt ttcattgaag 76500 tatgtttact gggtctcatt agattttctg agtttgcctc tttaaataat aataggcaat 76560 ctgactggac catctactta ataaagtctg cacacagcaa ttaagtgtgg taacaggcac 76620 aggtgcacct tcttatccag cacaaatgtt tttagcatac aagtctgatg tcctagctac 76680 tggcaaacag aaatataaac tatttaaatg catccctgat cctagtgcaa gttcaccttg 76740 gtaccacttg ttatggaacg gtgacccgag attcacgaaa agacctataa tatgcttccc 76800 tctctcatta ggagtcacaa ggtagcattt tttagcaggt gatggceaac agtaacagcc 76860 ccaagatggt gtggttgctg gctcttggcc tacctgggca aatctcattc gattccgctg 76920 gtaggccgtc ttctgtgtgc gcgctgtatc caccagctgg aagctacttt catcctcctc 76980 atggaaataa gcatattgac ttccaccacc aaactgagag gagtacttat ctggaggcaa 77040 aggtgatggc atgtagtaac tgcacccaca gactttacca gatatgcacc agtctaaagc 77100 cttgctattt caagtgtggt cttgagacct gtagcattgg ctgaaagctt gttagacaca 77160 cagactcaca gtcccacccc atacccactg aatcagaacc agcattttaa caagatcccc 77220 ggatgattca tatgcacatt caattttgaa caactctggc ctaaagaact ttctaagcca 77280 agaatctgaa ggactcaaac taacccattt cactctctgc gttattgtgt gagaatctga' 77340 ggtatttatt gctaaccacc atctccatta tcaggggccc atggcaggta tgtctaatag 77400 atcacgatat actttcttgc caatctcagc ctcagctatc ctaacttagt tctccaggca 77460 gccacctcca actatctgaa gtggcagaga gaaaaagcct ttttatggta ccaggatctt 77520 aaaaccaggg gttttacttt tttttttttt tttttttttg gagacaggat ctggctctgt 77580 caccaggctg gagtacaata gcatgatctc tgctcactgc aacctctaac ttctgggttc 77640 aagtgattgt cctgcctcag ccacccgagt agctgggatt acaggtgcac gccaccacgc 77700 ccagctaatg ttttcaacag gtttttaaaa gggcccaaaa ccccatttta ataggctaga 77760 cctctttaat gaatggtcta agttttgagg gctatttcca aaaatgtggt tattgttaaa 77820 gcccagaata catccctaaa agttatgaat tattgttggc agtttcttcc cattctaaaa 77880 agctttcaga agaaggtcat tagaataaag aacaactttc ccaaggccct gattggggca 77940 ttcagttgca gaaacactta cttgtgtacc tcttatcttg gtatgtggct cctgtccagt 78000 ctgcaaccta cgaagaacaa gaaaagacag agaatgcaca ggtcaaccag gcaagtttct 78060 gcagaaccag aaatccctga gcgcgagagg acagcgtgga agagtctcag aatttgttca 78120 caacacctct gtaagtgccc agctcttcta tgactacacc cagagataac ctttctcagc 78180 tggcatccct ataagaaatt caggagttaa gattttgaga caataaaatc taaacaggga 78240 ctcgagagta gcagccacag ctgcaaagat tcagactcct gctgacaggc atgtaccttt 78300 cctagccgat ctcctttgct gaacggctgg tagggcatat cccgaaactg ctcgggaacc 78360 gcacagggac cccagcctga ggggttgtcc tggatcacgg gtgtcatgaa ctttgccatc 78420 ttccaaaatc tgaaaaatat aaatcatgtg agtagcggca tgaacgaagg cctcagagta 78480 caaaacaccc tccatatgaa gtaagcaaag acataaatga tagaactcaa aaagcaacac 78540 gcaaaatgga accctcaact gttgagcgac tactactgtt tttgttaatt atactgtgaa 78600 tatgtactta aaactgagaa gaatgcaaac aaaactgatt tttcatattt cattaattcc 78660 acgacactct ctttttactg taacatcttt aaaatgaggc tgcaccttgt gtttgacagg 78720 gtgttgtatt gattggtagt ttttcttttt ctgtgttaca taagtgttta aaaaaattta 78780 atggtgtcag atttgataaa atgtcctaat gttttttcaa atatagtaac cttgttttgg 78840 ttctgagata taccttcacc aattcataca aactcaactt ccctaagact tagtagtctt 78900 ttctttcttt cttttttttt tttgagacag agtctcactt tgtcacccat gctggggtgc 78960 agtggcgtgc aacttccgcc ttccgagttc aagcgattct cctgcctcag cctcctgagt 79020 agctgggatt acaggcaagc gccgcctggc tattttctgt gtttttagtg gagacagggt 79080 ttcaccatgt tgtccaggct agtcttgaac tcctgacctc aaatgatcct cccgcctcga 79140 cctcccaaag tgctgggatt acaggcgtga gccaccacgt ccagccacct tagtcttttc 79200 catctgcaaa ataaacaaga tccttgttct aagcactttg tataatgcca cacaagtatt 79260 cagacttgca aaagtgcatt tatgtatata gagtgctgag aaaaaaagat ctttaagtat 79320 atcctgaaat tcaattttcc tttctcattg tttcaatttt ctgccatcaa cgcaaatcct 79380 gtgtgcagtg caagcggaca taaagccagg cagaagaact gccagagggc caaggaggtc 79440 cccacagacc tcaggcccaa agttgccatg ttaaatgttc atgaatactg ccaggcactg 79500 ttcttactgt ttaccactca ttcattcata cagtcctgcc aacaatcctg tgaggtagga 79560 gccaatgtta tccgcactct ccagataaga aaaccaaagc acagagaaat gaagaaattg 79620 cccaaagttg aaatgctagt ggatgaaaaa cgtgaaccaa agcagtctga ccccagagtc 79680 tgcactctgc ataatgctat agccctcttg ggaattaaaa aaccggcgct gtatagcaga 79740 tggctgcccg acacttctat aaaaaaacct atgcatttat cttccgttgt aaccttctga 79800 aaatgcttag aaggcgagtt cctagaggaa aattcactac acaagtattt cttggaggcc 79860 gggcgcggtg gctcacgcct gtaatcccag cactttgaga ggccgaggtg ggcggatcac 79920 gaggtcagca gttcgagacc agcctggtca acatggtgaa acccagtctc tactaaaaat 79980 acaaaaatta gctgggcgtg gtggcgggca cctgtaatac cagctactca ggaggcggag 80040 gttgcagtga gccaagatcc tgccattaca ctccagcctg ggcaacagag caagactccg 80100 tctcaaaaaa acaaaaatca aatgtttctt ggaggctgga gagcaatcaa aagaacaggt 80160 atgctgaact tagtaaactc tcctcaaagc cccatgctgg ggagattgag gcttccttca 80220 gagatgacat ttgggtgaca gcaacacagg atgaacctag aagtttcatc tttctaatag 80280 aaactatagg aagaggacag aagaaaaagg gtggtggtct cagaacaatt tgtattaaat 80340 aaatattgct gagctcctac gtgttaggcc ctataccaga taatttaaca ccattgacca 80400 cccccccacc cctactttag aggcaaaaat ttgaagctca gcctactcaa gcagctgacc 80460 tcatcatttc aaaacagatt tgatttccag ggttgcctgc tgtcagtcca gccttctttc 80520 cattatatta cagctgggca gcagcccgca aagatcaggg gtttgagacc gtacatcata 80580 ataccaagac aacgagtctc aaaacacact ttaaaaaatc gggttctgtc agaagctcaa 80640 gaagggaaga ggcccgaggc tcgacctgca tcacctccct ggaaagccag ggatgagata 80700 ccctggcttt aataaatgtt ttttttttta agagcagagc ggaaccagga ggagaaactg 80760 agccgctcag caaaaacgaa gtaacagctg tactagtcac aggggcagga tagggaggtt 80820 ccaagagggc actcagaagg ggctctgtgg ttggcaggcc actacagatc ataagccgtc 80880 catcgctgaa cagggggtgg ggtagattta agatcagaga tcaaatctac ttctctatcc 80940 tagcctccag tttcacaaaa aaggaaagat aacctatgca ctgtgaattc ctaagaacag 81000 gggccaaaca ccgctcagcc tggtacccct aagacctcac tcaaaaagtc agggagtttt 81060 cggccacttc agaaagactt tgttgttacc cctccgtctt aacccaggtg agttaagtga 81120 caatcaaatt cacccagctc atgggcactg agcagggccg agggccaagg acctcaccca 81180 caaggtcgtg tcccgcgttc agtagcgtgc gggacgcggg gcccccgaaa gtggattcct 81240 gccccgccca gcggagggac ggcaacagca ggaagggact aagagaggtc tcttccggga 81300 ggccccccga aggctggacc tagtccgaac cggctccgga gggccgcagg aacctatgaa 81360 acacgccgct cacctgcaat ggcctcggcc ggccgggatg gcaacagatg gtgcgtgccg 81420 gggaccgcgt tagcagcagc actcttgaga aaccaggaaa agaggaaaca tgcgcgcgca 81480 gcgggcgccg ccgtaaacac gaccggcgct gtcgtaaact gctctcccgc ttcctctggg 81540 ttgggcggaa gaactcacga gccgtaaagc gaaggtccac ccggaaatcc gttactgcgt 81600 ttcgccaggc gtcctcatta gcctccgagg cgccgagacg cgagaggtgt gattggcact 81660 acgtcaggcg gtatccgggg acgcccaaag agggcgttca tcactgaaac ttggcggccg 81720 cgcaatcgaa gctcgaggcg gggagcgact ggcgcccttc tgtgtcccac aatgcttcgc 81780 ggcgcgcctc agcccccatg tatcccaccg tcacccgcga ctccccgcct gttctacctg 81840 cctgcttaat gtgaaactca gcgcagggga ggtccgtcgg tgtcttaggc ggtccttatt 81900 gttactcctc cgcctttata gttgtggaaa ctgaggctca gaagtgccaa gtgacctgcc 81960 tagatcagac tgttagttta gggttctaac cgccagagtt caaaccatac ttccgcagtt 82020 ctcaaactta attgtaggac agggatttct ggaacagtgt ttttatttat ttttatttat 82080 tttttgagac agggtttcgc tctgtcgccc aggctgaaat gtagtggcag gatcacggct 82140 tattgcaccc tcgacttctc aggtacaagc gatcctccca gttcagcctc ccgagtcgtt 82200 ggtgtacaca ggcacgcaca accacgcctg cctaattttt gtatttttgg tagagatggg 82260 gttttgctat gttgctcagg ctggtctcaa actcctgagc tcaacagtcc acccactggg 82320 gctagggtta caggcatgag tcaccgtacc cggccagcta atgattttta aaaattttgt 82380 agagacagcg tctcactatg ttgcccgggc tggtctttaa ctcctggtct aaagtggtcc 82440 tctcgcctca gcgtgcggag cagctgaggc tacaggtgca tgccaccatg cctggctaat 82500 tttttttttt agacggagtc ttgctctgtc ttccaggctg gagtggagtg cagtggcgct 82560 atctcagttc actgcaacct ccgcatccca ggttcaggtg attctcctgc ttcagtctcc 82620 cgagtagctg ggattgcagg cgtgtaccaa catgcccggc taattttcct tttagtagag 82680 acggggtttc accttgctga ccaggctggt ctcgaactcc tgacctcagg tgatctaccc 82740 acctcggcct cccaaagtgc taggattaca ggcgtgagcc actgcgtccg gctgcctggc 82800 taattaaaaa aaaaaaaaaa aacttctgtg gagacgaagt ctcatcatgt tgccaaggct 82860 agtctcaaac tcctgggctc aagcagtcct cctgtctcgg tctcccaaag tgctgggatt 82920 acgggcgtga gccaccacac ctgaccagga tagtattttt aaaaattcag attctgggtc 82980 tcattttgat agattatacg gatatgttta tgctggagcc caagagctcc gcattagctg 83040 tgattctgaa gtgacgactc aggaactgct ttactacagt agataacagt gctgtcctct 83100 cagcaactcc caggctatgg agttcctcct ggtgtctttc tttcggaatt ttaaaacaat 83160 gaaagataat ctgagggcat gactttattc aaacctcaga tcctttctac ctgacatagg 83220 tttccttagc cgcctagtat gtctccttta ttagaaaata tacctgaagt ctaggctctg 83280 ccacattctt ttttttttct tttcttttct tttttttttt ttgagacgga gtgtcgctct 83340 gttgccaggc gggagtgcag tggcgcgatc tcagctcact gcaacgtcca cctcctgggt 83400 tcaagtgatt ctcctgtctc agcctcctga gtagctggga atacaggcat gcgccaccat 83460 gcccagctaa tttttatatt tttagtagag acagggtttc accatgttgg ctgggatggt 83520 ctcaatccct tgaccttgtg atccccccgc ctcggcctcc caaagtgttg ggattacagg 83580 cataagccac tgtgcccagc cagctctgcc acttgatagc tatgtgtggc cttcacattc 83640 cttgccttgt ttccttattt gtaaattgaa gatgataatt agagggcgct gtgggggtga 83700 aaataaatgt gtgtgaaagg acttagtaat tccacttatc atttgggtga acttggacag 83760 gttattcaac ctcttttttt tttttttttt ttttttgaga cagagtctcg ctctgttgcc 83820 caggctggag tgcagtggcg agatctcggc tcgctgcaac ctctgcctcc caggttcaag 83880 caattatctg ccccagcctc ccgagtagct gggattacag gtgcccacca ccatatcegg 83940 ctaatttttt gtactgttag tagagacggg gtttcaccat gttggtcagg ctggtctcga 84000 actcctgacc ttgtgatcca cccgcctcag cctctcaaag tgctgggatt acaggcgtga 84060 gccaccgcac ctggcctatt caacctctct aaacctgctt attcatctga aaaatgagaa 84120 tgctaatagc agcacctatt tccataagct ctctcccaac tgctcatttt ttttttttcc 84180 taatttttgt taatggtgtc tggtgaattg tgcccagtgg aaagccttgt agtcatcact 84240 ggtagttcgt ttttccttcc ctcccacatt tagttcttca ctatgttctc tttattctac 84300 ttgcacaatg catcttgaat gctatcactt tttttttttt tttttttttg agacagagtc 84360 ttgccctgtc acccaggctg gtgtgcagtg gcgcaatctc agctcactgc aacctccgcc 84420 tcccgggttc aagcaattct cctgcctcag cctcccaagt agctgggatt acaggcgtgt 84480 gccaccacgc ctgcctaatt ttttgtatct ttagtagaga tggggtttct ccatgttggt 84540 caggctggtc tcgaactctt gaccttgtga tccacccgcc tcggcctctc aaagtgctgg 84600 gattacaggc gtgagccact gtgcccagcc gaatgctatc actttttatc cccatttcac 84660 atcacgcttg gatacactct tgctgctcta gggtttcttc tctatatggt ggtcaaagga 84720 atctgtccac aaccttctac tagcttccca ttatatgctt agagggaaat atgaatatct 84780 ttttgtggcc tgtgtggtca ctgtctacct ttgttatttt taaaatattt acttctttga 84840 gacagggtct tgctctgttg tccaggctgg agtgcagtgg tgtgatcatg gctcactgca 84900 gtcttgacct tttgggctca agcaatcctc ccacctcagc ctccgagtag gtgggactag 84960 aggctcatgc tgccactcct ggctaatttt taattttttg tagaaatggg gtctcactat 85020 gttgccccgg ctggtctgga actcctgggc ttaagccatc ctccagcctt ggcctcccaa 85080 tatgctggga ttacaggtgt aagccacctc acctggccac tggtctacct ctagccacca 85140 tattcttctt gtgccttaaa tacactgaac ttctttcttt ctttttcttt tttttttttt 85200 tgaaacggag tctagctctg ttgtccagcc tggagtgcag tggtgtgatc ttggctcact 85260 gcaacctctg cctctggggt tcaagtgatt ctcctgcctc agcctcccaa gtagctggaa 85320 ctacaggtgt gtgcctccac accaggctag tttttgtatt tttagtagag acggggattc 85380 atcatgttgg ccaggctggt ctcaaactcc tgacctccag tgatccatcc accttggcct 85440 cccaaagtgc tgggattaca ggcgtgagcc actgtgccca gcccaccagc cttctttcca 85500 tctcagcagg gcctctggac ttgacgttct ttctgcatgg cacactcttc ccccaggttt 85560 cctggtagtt gaattggtct catcatctat gcctctgctc gagagttaac tccttatgca 85620 ggtcttttct gaccatcatt tctaaaacag gtgattgtat tagtccattt tcatgctgct 85680 gataaagaca tactggagac tgggaaattt acagaagaaa gaggtttaat ggacttacag 85740 ttccacatgg ctggggaggc ctcacaatca tggcagaagg caaggaggag caagtcacat 85800 tttacatgga tggtagcagg caaagagaga gcgcttgtgt aggggaactc ccccttttaa 85860 aatcgtcaga tcttgtgaga cttattcact atcatgagaa cagcatggaa aagacctgcc 85920 cccatgattc gattacctcc ccctgggtcc ctctcacagc acatgggaat tcaagatgag 85980 attttggtga ggacacagcc aaagcgtatc actggcatag agtaggtgct taagtaggta 86040 ctcattgact gagttaatga aaaaaagaat ctggccagtg gtggtgtctc atgcctgtaa 86100 tcccagcact ttgagaggcc aaggcgggca gatcacctga ggtcaggagt ttgagaccag 86160 cctggccaaa atggtgaaat cctctactaa aaaaacaaaa attagccagg tgtggtggaa 86220 ggcaccctgt gatcccagct acctgggagg cggaggttgc agtgagctga gatagcacca 86280 ctggactcca gcctgggctg caagagcgaa actccatctc aaaaaaaaaa aaaaaaaaga 86340 aagaatcaaa attggaggac caggtgtggt gtctcatgcc tgtagtccca gcactttggg 86400 aggccgaggc aggtggatca cctgaggtcg ggagtttgag atcagcctgg ccaacatggt 86460 ggaacctcat ctctactaaa aatacagaaa ttagccaggc gtggtggtgg gtgcctgtaa 86520 tcccagctac tggggaggct gaggcaggag aattgcttga atctcgtaag tggaggttgc 86580 agtgagccaa gatcacacca ctgcactcca gcctgggtga cagagtgaga gtctgtctaa 86640 aaaaaaaaaa aaaaaaattg gtatgagatt aactggcatt aatgaggacc actcctcggc 86700 agcagacctg ttgtatttat gatcaataat gtgagattct tgctttcaaa gggcttccat 86760 tccaaccaaa ggaatgatga cagaaatgtt tttttttctt ttttaaaatt ttttaatttt 86820 aattatatat ttcattttac tcaatatatc caaaatatta tcaccatacg atataaaagc 86880 cttattaatg ggaatgtttt acattctttt ttgtgctaag ttaccaaaat ctggtatata 86940 tttcacatgc atggcataac tcaatttgca ctagctatat ttcaaatgtt caaaagccac 87000 atgtagctaa tgactattat attggacaga tctaaatata gagttttcct gaaacttaaa 87060 gacgtttcat gagactagca cttagtaagt gtggacaaga gaggaatgag atgaagctgg 87120 agtgggacag gcagtgatag atcacacagg gcctggtagg cttgggaagg agtttggatt 87180 ttatactaat ggcattaggt cacctcctac aagaagtctt tcctaatgtc ccaaaaagag 87240 ttaaccactc catctcttgt gccaccatgg cttttgatga aaaacccaat atggcacccc 87300 ggattcttta ttatatcttt tagtatatac atggctgatt tctcctcaag ggcagtgaat 87360 gtgtctttat tcatctcttt attcccaagg cctggcacac ctcttagcat ataataggta 87420 ctatatattt attggaagag tgaatgagtg ggggtgcgag aatggattcc ttcagatcta 87480 ttttccagct cattaattct ccctctagct atgtctcatc tgctatttaa cacatccctt 87540 gagttttcat tttaacaact atgttttcat ttctaaaata tctgtatggg ttctttttca 87600 aattagcctg gtcaatttag agtttcttct acttatctcg ttttgtgatt ctacatttca 87660 tatctttaaa tatttcatag ttattttata ttccataccg aatagttcca atgtatcaag 87720 tgccttggga tctaaatctg ctggtgattg attttcctga ctctcactca tggtggctta 87780 ttttcttctg tatctgattt tcttcagttg tgagttcaca tttgttcgat cttaacctgt 87840 cctgctttag cagtggtttt caaagtgtgg ttcctggacg agcacaataa acagcacctg 87900 ggaatttttt agaaatgcaa gttctagggc tgggcacggt ggcacatgcc tgtaatccca 87960 gcactttggg aggctgaggt gggtggatca tgaggtcagg agttcgagac cagccggacc 88020 aacatagtga aaccccatct ctactaaaaa cacaaaaatt agccaggcgt agtggcatgt 88080 gcctgtaatc ccagctactc gagaggctga ggcaggagaa tcacttgaac ccggaaggtc 88140 gcggtgagca gagatcgctc tactgcactc cagcctgggc gacacagcga gactccgtct 88200 caaaaaaaaa aaaaaaaaaa tgcaagttct agagccccca tcccagactt gctaaatgag 88260 aaatgctgaa agtgaggccc agtaacctgt atttgacaag ccctatagaa ggttctgaca 88320 cacactggcg tatgaaaacc actgcttgca agataatttg gtttacctct ttaggaagcc 88380 aaggagtgct accgaccagc agccacttta gtttttattt ttaatttttt agttttttat 88440 tgactatgcc ttataaaagg accagcagcc actttaactt tttggggctg ggcttaaact 88500 agagttgcag gctcagcttt actatgctgc tgctggccta aggctgttta ctgcctgtag 88560 tgctggtatc atttgcagtc agggcaatct tacctttagc gctgtgttct tctccactgc 88620 tttcccctcc tgttccacct caatataatt ttgtgggagg aggaggggag ggttgaagga 88680 actgtcttca aagatttctg taatttacag tgaacccaaa aattacatta aaagtctgta 88740 ttatccagga tcgagctgtt ttaccatggg aaagcccatc agagtaccca accctccata 88800 tggccagaaa gaacaactct gtctgaatac acgagtttca ggggctgctt gtgccttcac 88860 tcattagggt taaaacatgg tcttaaagct gaaggccgcc tctgacctga cagctccaag 88920 tcctgcggac tcctgcgccc agtaatcacc tccatggcga agcactgttc ctgctcccgc 88980 aggcggctat aggtccacag caggctctga aagtgctccc acagctggac acgctgcccc 89040 aggtctgggg gccgcagcct gagggcagag ccagagaggg cgggagagac cacgagaaag 89100 ctggtctctc ccacacccaa caaaaggacc agagtcccag ctcagtgtta gagccaggtg 89160 agcccatgtg acctgcccac acagctggga aagcgggtcg ggtttctggc ccagctctag 89220 ctgtggagtg gggtgggata ggcacggagc cagaaggcag gcagctgagc aaatcacctc 89280 actcttcaat ctctgtcaca caaacacatg tcatataaac ccagctagag agagccaggg 89340 tggtgcttaa gcttctcaca cagaggccac tgaacacaga aaggtctggt ctatcatcag 89400 ggccctacac agggttgcag ccatctcgga tgctggcaag gtctgcactg gccaatgtgg 89460 ttcatgtaac aggcatctac cacctgcagc atttgccact gaaaccatga cctatctggg 89520 ctaaaatggc tcatgaaaca atgtttgtgc atttga.gaaa tgcctcgagc atgtacagct 89580 tccgctgcag gtccccctcg ctcttggtgt ggtcgccatt gatggcaatg aacaggcatt 89640 ctccaaacag gtgaaggaca tacagggagt tgctgttttc catggagaag caggtgtagg 89700 tgtccgagag cttctccagc atcgtcatgg aggagatgat gaccggggct aggagggggc 89760 tgagctggtc ctgtagggca gggagctctt cttcctcatt ctctgactgc ccgaacttca 89820 gctggagact ctcttcaaac tcctcatccg tccagtagaa gagggcctct gtgccctcaa 89880 tggccaccaa gatgcacttc atcttggtaa ggagcacagt ggagcgtcca gacagccaga 89940 ggttcagaaa gggctgcagc agacagactc tgtgactgcc tcatcggaga gcagcacaac 90000 atccctggtc ctgcaaatgc ggatcgcggc gtgcacagca ccccgcctgc gggacagaaa 90060 tgttttctga actgaaaaag ggggactaca ggtgcctgcc aggccctcca tatacataca 90120 tccccctatg tctgtgtcta gaagtgagat acaccgttat ttctgttttc tgattggcct 90180 ttttagtttt ttgagacaga gtctccctct cttacccagg ctggagtgca gtggctcgat 90240 cttggctcac tgcaacctct gcctccgggg ttcaggcaat tctcctgcct caggctccgg 90300 agtagctgga attacaggcc tgcaccacca cgcctggcta atttttgtat ttttggtaga 90360 gacggggttt ggccatgttg gctaggctgt tctcgaactc ctaaactcat gttatccacc 90420 ccccctcggc ctcccaaagt gctgggatta caggtgtgag ccaccgcaac tggcccattg 90480 gcctttcttg ttgtactgtt ctgtcccttc caggtaagac aggtacattt tctagtagta 90540 agctcctgtg tcttaaaaaa gaaaataaca ttcattgagt gcttacttta tgccaggcac 90600 tgtgctatgg gctttatata aataatttcc tctctgaaaa aaacaaagac aacaaaaaaa 90660 attacttctt tgattctttt ctaaaagttc cttgaaattg ccatggaccc tcccattcgt 90720 gcaggtgggg agaaagaagc tcagagtcgt tgagtacttg gcccagtgag taaatggtgg 90780 agccaggatt tgtgaacagt tttgtggact cagaagcttc catcccttac aggggtggtg 90840 aagaaggcct ttccgagagg cccgagaggc cccaaggcag aaccatccag ccaagcccac 90900 cccaaattcc tgtcccacag aaaccaagag agataataaa aagacggttg cagggttgtc 90960 tcgcccctcc tctgtctctt gcctgctctc tctaaggaat tcagagcctt cccatcttga 91020 ataccagcgg cagctccaga atttccccgt gggacaggct tactgagagc cgtcttgtga 91080 agggggtagc cctggacttg cctgggagct gtgtctgtgt agcaggtact ctgctttcag 91140 gaggatgcag gttttgttgg gggagagtgt tccagggact gtgaggggac tgagcctgct 91200 cctgaagcca tctccttttt atttaatttt atttttttga gacagagtct cgctgtgttg 91260 cctaggctgg agtgcagtgg caagatcttg gctcactgca acctccatct cccggttcaa 91320 atgattctcc tgcctcagcc tcccgagtag ctgggattac aggtgcccgc caccatgcct 91380 ggcaaattgt tgtattttta gtagagatga ggtttcacca tgttggtcag gctggtcttg 91440 aactcctgac ctcaggtgat ccacctgact tggccttcga aagtgctggg attacaggca 91500 tgagccactg cgcccgaagc catctcttgg taaaatactg ctgagcattc agacagaaca 91560 gaattaggag aaagagaagg aaccagcatt gatttcttca acacactgtg ctaggtacct 91620 caggcatttc gattattcta ggctgtgagt gaagagttgt tgccagaatc taaagtgtgt 91680 tctgagaact tggccaaatg tagggtgacc atatgactta ccattcaaat ttgggacact 91740 ttgggggtga cgaagggatt actatcaata attatgccct gggattgtct cacttaaact 91800 gggaggtatg gtcaccctag gcagaaggga agtaaaatgg tcctctgtta ctgattatct 91860 gttgctgtgt aaccaatcac accaaaattt agtggtttaa aacaacaaca gtctttttat 91920 tatatctctt agtttctgtg ggtcaggaat tgggagaggg cttggctggg tggttctgac 91980 ctggggtctc tcatgcatta tagtttggtg tgggtggagc ttctgttttt ctctctctcc 92040 atttagcctc agggtcattc tgtagtgagt ccatgtgggg agttcagagc aagtattctg 92100 gcgaacaagc tggaagccat gctgccttct gtgatctagc ctccgaagtt atacagcatc 92160 tctcccatcc ccgtaacttg ttggttccaa gtgagtcaca agcctgccta gagtcaaggg 92220 cgagggagga cagagactga atttcttgct gggtaaggca caaagttatg gaacaagtat 92280 gtggagtggg aggtattgtc gtggccatct taggggtatg aactctgcca tggatgcaga 92340 ctggcctttt ctaagagtca tcagtttggt tatctgcaaa catgactgaa gagtgtgggg 92400 tacatcaatg ccaggcaaag tttctgaagg agtctggctc agagggggag gcctggaata 92460 cgatcctagt ttaccaaggg gaacctggtc agttaccttg caactttgga gaaagagtga 92520 atggaagtgt ccctcagtag gggacattta ggaaggggat ggtcacagag ccagggctgg 92580 cattgtccag ggcacaggtt cttggttgcg ctggctcaag catcatcccc attccccggg 92640 taagactgtc ctcccaaaac agaggtggct tcaagctgct ctgtgataaa cacttttttt 92700 tttttttttt tttgagatgg agtctggctg tgtcacccag gctggagtgc agtggtgcaa 92760 tcttggctca ctgcaacctc tgcctcccag gttcaagtga ttcttatgcc tcagcctccc 92820 tagtagctgg gattacaggt gcctgccacc atgcctggct aatttttgta tttttagtag 92880 agatggggtt tcaccacgtt ggtcaggctg gtctcgaatt cctgacctca tgatccgccc 92940 gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc accgtgcctg gccgataaat 93000 gcttcttaat gctgttgttt attctgactc cctgccacca agcagtgctg tgacaccgtg 93060 gatcctcatg gaacttgtgc tgtagggaag cacgtgctgg ttaggctgat ggaagtgctc 93120 cattctgctg gtggggtatt tactgtgctc tccaataata aatggatctt ctgctatgcg 93180 tcagccttgt aagtttggtc aaagggagtc tgccaccgcc ttgtgtgcag aaagatcccg 93240 gatatcctgt ggtggattca cctcattggg accggtcagt gtggccaacc tctcttccag 93300 agtggcaact tgcgtttcct tgcttatctt ttaagaagca ccataggaat catcacccca 93360 ttttatagac gagaacactg aggctcagag aggaggaatg tcttgcccca ggtgagccag 93420 ctggtcaggg tgcatttgga atggaaaccc aggtgtggct gaaaccaaag ctggcactct 93480 ccatgcacaa ttccaaaacc cacaaagctc tgaaaatcta aagctttttc atgagattgg 93540 ggcaagcatt tgatggcaaa cctgatatga attggatgtg aggttattta tagtctttat 93600 tttgtcccac ttagcgtgaa tatttataca ttttgctgca gaaaaattaa agggtttatg 93660 gaatattgct ccagagctca ctggcatgtc acctgatatg cggtagatcc actcgaaaac 93720 ctttcaggaa tccaaagaat tccaagttat aaagcacatt gaggccggat gtggtggctt 93780 cagacctgta atcccagcac tttgggagcc caaggcgggc agctcaccag aagtcagtag 93840 tttgagacca gcctgggtga aacctcatct ctactaaaat acaaaaatta gccaggcgtg 93900 gtggtgggtc cctgtaatcc cagctactgg gggaggctga ggcatgagaa tcgcttgaac 93960 ccaggaggtg gaggttacag tgagccaaaa tcgggccact gcactccagc ctggccgaca 94020 gagtgaaact gtgtctcaaa ataaataaaa tataaaataa aatacataaa ttgataaagc 94080 acattgagcc gcgaggattt cagataagaa attgtggagc tgtgctacct gtaccaaact 94140 tttctgtctc ggttaggcag agatcactac ccccattctg cagatgagga agactgaggg 94200 caaggaacat ggtgtcccag gtaggacggc agccatttta tcatcctgtt ggaggctgtg 94260 ccagcaggaa aggaagcttt ggagccacca gcccacccca gcctcccaag aaccttgttg 94320 tctcagcaaa atttcagaac tagaaaacct ggaaagatta aagccccaaa gaatgccaca 94380 agtcccccag gaagaaaggg aggctttgct gtgcgttcca gtggtcgaca ttctaaatca 94440 ttttttattt cagctgcatg tacactcacc catcacagga ccagttctca gaatagagag 94500 gtacctgttg aatcatccac cctacttcct gcctcgtgtg ggcatgtctc caagtgctga 94560 gccatccgct tcgctgccgt ggcctgagat atatcaggat ttgcaggcct ggcgacagga 94620 gacaaaatag attcccattt ccttcagaac catttagcta gtttagagag tgtttgactg 94680 tttcaatggg atgagcaata accaggcctc tccttggctc cttctctctg ccccatatgt 94740 tttcttctgt tggaagctgg gatttggggt cttagggcca aagataaata ctgattttgg 94800 ctcgatctgg ccgcacagct gtgggctagt aggtgcccct ctctgaacct caggccccca 94860 ctttctgcag cacagtgttg ttctcatctc tgtttttttt tttttttttt ttttttgaga 94920 tggagtctct ctctgttgcc taggctggag tgcagtggtg cgatttcagc tcaccgcaac 94980 ctccatctcc tgggttcaag caattctccc cacctcagcc tcccgagtag ctgggattgc 95040 aggtgcctgc caccaggccc agcggatttt tgtgtttttt agtagagaca gagtttcacc 95100 atgttggcca ggctggtctc gaactcctga cctcaggtga tccgccctcc tcagcctccc 95160 aaaatgctga gatgacaggc atgagccacc gcatccggtc tctcatctct tcataccaca 95220 tgccttggtt cccactgccc cggcgggtgc ctggagagcc ttgtggctgg ggctgagtga 95280 ccgcaaggtg atatttaagg tggtctcatg gagcagtctg acatcactgt aatgcaagca 95340 gacatctggg gagtcagact gactgaattt gaattccagc gatttaaatt tttaccactg 95400 ttgtgtgacc ttgggcaagt tgtgtgacca tttgagccat agcttcttca tctgtaaaat 95460 agatggaatc atagcatgta ccacttcggg agggagggag aatagaatta ggtcagattt 95520 tatatgtgac atgcttaagg cagtgcctgg catgcaaata agcccttgat acatgccagt 95580 ggggttactc tggttaccag aaacttggaa gtaggggctt tggctggggc aagatctcgc 95640 aacatttaaa~aagcaatcac tgaccgggca ccgtggctca tgtctgtaat cccagcactt 95700 tgggaggccg aggcaggtgg atcacgaggt cagaagatcg agaccatcct ggctaacacg 95760 gtgaaacctc gtctctacta aaaatacaaa aaattagccg ggtgtggtgg tgggcgcctg 95820 tagtcccagc tactcgggag gctgaggcag gagaatggca tgaacccggg aggcgaagct 95880 tgcaatgagc caagatcatg ccactgcact ccagcctggg tgacagagag agactccgtc 95940 tcaaaaaaaa aaaaaataaa taaataaaaa gcaatcactg gtcactcgtg aggaaccagg 96000 ccccgagttg gtcactcagc gttcaggtgg agaccttgcc atgctatcaa gtaacctaga 96060 gtctattttt ttttttaaga tggagtttca ctctgtcgcc caggctggag tgcaatggca 96120 cgatcttggc tcactgcaac ctctgcctcc catgttcaaa cgattctcct gcctcagcct 96180 cccgaatagc tgggattaca ggcacccgcc accacacccg ggtaatttct gagtagagac 96240 tgggtttcac catgttggcc aggctggtct'tgaactcctg agctcaagtg atccacccgc 96300 cttggcctcc caaagtgctg ggattacagg tgtgagccac tgtgcccagt caagtaactc 96360 agagtctaat ggggaaagta gatgtggcta atccaggggc tgcaatacct ataaagtcct 96420 taatcaaata tattttgcgt ctatgtttaa aaagcagatt tcacctaaaa atctagtttt 96480 ttggcttctc ttaagatctg gcaacaccgg gctggccttc ctgcgatacg agaagaagct 96540 ggagctgaat aggagttgcc cccttggcca ggggctctct actttgcctc agtccccact 96600 actccctatt gcaccagatt caaacttctt catagtcatg catgtttgcc gctggggcct 96660 gtgggagttt gctgataagt tgcagtgcaa tgctgtgggt gctgtgagag cacgatgagc 96720 aataataact cagccttggg cagtcaggaa aagcttccca agggaggcga agtcacagct 96780 gcttctctat aaaacctgca gatgctgctg aacaccctca tctttatggc tcaaggacat 96840 gaataaagga cgcaaagtca gagctcacga ggaatctctg gcataaagcg actgaggccc 96900 agtgacttat ctcgggtcac acagcctgct gatggcagaa gtggggctag aactaggatt 96960 accaaccaga aacctttttg gactactttc cctagaacca gagctgtcaa ccagaaacag 97020 ttctgggcca ctctacctcc cctgtctctg gattcctcgg gagttaggag gatttgtact 97080 ctggaatctt agacttgagt cctgtctctg ccatttactt gcagtatgac ctcagatgag 97140 tcacttcctt tccttgaacc tcagtttcct catctgtaag gtagagctaa ggattctgac 97200 ctcaaaggag tgttctgagg gccaaacgtt gggaaagtgg acaggaggca atctcagaca 97260 tctcattagc tcaagaggac tctagatacc tgagggtcat tatgactgtt gacaagtagc 97320 caccttctcc caagagattt tgttaccatc tgtttaacag tgaccttgaa ggggatccat 97380 cccccacttt gcccttgcca gtcccttaaa ggagcacgca tggcctttgg tcaggcttgg 97440 accctggaag ggaatgcttt gggattctct gactttgggt gtgaactggg ccctggatgc 97500 agagcccaag ggttcccctc tcctgggagg ctccaaggtc acagcgagta ctagggtaga 97560 gttgggaagg aagcagaatt tcctgggcaa aagaaatgtc aataattctt ttgttttctt 97620 caaggcatct acctgcctat ctggggctcc ccttaaatcc catgtctgtg gctggaacta 97680 ttgagactct cctactttga ggaggtccca ctgtcctgag ttcaaatcct gacttttctc 97740 cttattagtt gagtgtgact ttggttggac aagatttcaa attcctctaa actccaatgt 97800 cctcatctac aaaatgggcc tcttaagagt acacatttgg taaggtttag tgggaattaa 97860 gtgagattat gtgtgaaagg gtttagcaca gtgtagagct cagtcaatgc ccgttattac 97920 tgtgattgga aattagaatg attgccaccc atcgtgtttg tataacactt gaccatttct 97980 gaacttatgc ttctcttacg ccatttgatc ttcgcaatga ctctttgagg tggccggtgc 98040 agggatcatg acctcattgc acagatgaga caactggagc tcagagaagg caaccgtcta 98100 ctcaaggtca cacagcttga gtatggcaga gtggcagagc caagttcact tcttgttctt 98160 tttttttaag atggagtccg gctctgttgc ccaggctaga gtgtagtggc atggtcttgg 98220 ctcactgcaa cctccgcctc ccgggttcaa gcgatttcct gctaattttt gtatttttag 98280 tagagaaggg gtttcaccat gttggctagg ctggtcttga acccctcacc tcaagtgatc 98340 cacccgcctc ggcctctcaa agtgctagga ttacaggcgt gagccaccac acctgatctc 98400 aagtcttctg agatgaagat taaacagcac cttccacagg gtcagaccgg acgagacaag 98460 accaggcttt gaccacgtgg ttgggttgtt ccctgggtgc ttcatatctc ccaaaaactc 98520 cttgatagaa ataatccaca atgctgtttc aaaccctttt tgcctctgtt tatgctctga 98580 gcctgtacca cctctagggg cgaagaaact tctcctttct ccgtggcgtc aaacggactt 98640 ttccttgtat ttgtcctaaa gggacctcag cagcccctcc ccgttgggtc cgtcaaagca 98700 ctctgccaga aggtctgtgt gttcttcagt gtgggcacat gatggcgctg ctccacaacg 98760 catgaaaaat caggcccaac ccacccctca ccccccgccc cccggactgc atttcaacgc 98820 atcaaagatc aattaaacac ctactatgtg caagtgactg tgattgctcc ggggagggct 98880 tcagttattc aatactgtta tgtttagcta tattaataat agccgtaata acatcggtac 98940 agggcttcat agtttatcga gcaatttacg tggattatct ggttctatct gccaagcagt 99000 cctgatgcgt tagatcgggt gggtctttct gtcccacttg aggaggaaac tgaggcacgg 99060 agggtgacag aacttatgta aaggcacggg ggagagaggc acatggtagg catttgatga 99120 attataggtg gtggatggaa tgaggcagac ccaggcatct atctcctcca ggttgttatt 99180 catcagtgag ggccgggatt gtatcttatt tgtctttcca tccccactcc tagcacggct 99240 tctgattgag ggcttccaca gacctctgtg gcagggagag gagaggcagg gggattccct 99300 gtaggctgca atgccgaaca gctcctggaa ggctctctga gggtgtgcag gctgagagag 99360 gtggcttctg ggctggagac tgcaaagaga ggaggtcact gccttcaccg tgtagcattt 99420 gcaggacatg aatgactcac cgtaattcag ctcctgaagg caccaagtag ctgagtggtc 99480 aggatgattc attcattcat tcaacaaacg ttttctgagt gcctgttaca tgctaagcat 99540 taagaatgca ggtatgcaaa cacagcctct gtccccctgg agcttccaga gcagtggagg 99600 agatggaggg caaagagcta gcaatgcggt ttggtttgag ttgcccagaa gtctgtactg 99660 agtgccacgg ggtaaccaag tctagtggca cagtgtgaag gctacaagag ggggagatgt 99720 tttgcaggat ttgaaggatg aaatgaattt gcagataacc agacaaagaa aggtgcatga 99780 ggactggggg aaggaaagca tcaggggcag tggggtatgt acgggcagga gctgtcaaag 99840 ggcgtcagtc atgtgtttga ggatgggtaa cagatgcagt aggaaagaca gtggtaccag 99900 cagggagggc cttgaaagct attctgagga ctgtgaattg catcttgtat ttgtcaggga 99960 atcaccatgc tgggagctct gctaggagct cagagttcca tggagaaggt gggcaaagag 100020 aggcccatca ctcatgttta ctgagccttg actatttcgt ggtgctaagc acttcttggg 100080 ccttggttta ttgtctgtct tataaggcag gtactgtgat catccccatt ttatacacga 100140 gtaaactgag acttgggata ctgacataag tttttcccaa ggtcataaaa ctggtactag 100200 tggagtcagg acttgtcttt tttgtttttt aatggtcacc tttactaaag ctgaagtgta 100260 tgggtttttc acggatgggg tacaaaattc aaaaggctca aaaagtccca agtgaggttg 100320 ctcttctttt tttttttttt tgggatggat tctcgctctg ttgcccaggc tggagtgtag 100380 tgggatgatc ttggctcact gcaacctctg cctcctgggt tcaagcgatt ctcctgtctc 100440 agcctcctga gtagctggga ctacaggcac atgccaccac gtctggctaa tttttttgta 100500 ttttttagca gagacagggt ttcaccatgt tggtcaggct ggtcttgaac tcctgacctc 100560 gtgatctgcc caccttggcc tccctccctc cccagaggtg actactctta cactttcttg 100620 tgttttttat tttctagaga ctttgcctgt ttgttttgtg agaggtgttt tatatagaca 100680 taagcacaaa aagcaagaca agacaagtgc ctgttaacta caaacatggg ctttgggaag 100740 agccagtgtg ggtttagatc ttgacttttt ctgagagcct gacaagtgtc accattaaat 100800 gctggtttgg acaaagggtg ggcgggcttg gagggtggga tgaggatggc agggggtagg 100860 gacgtggaca tcaagaggtc tgtgtgcaca agtgtgactg tgtgggcctg gactgggggt 100920 gaggtgatca gatggggaca ggaaatgggg actgcagagg cctggtgaga gacagagcag 100980 ggacgaggca ggggagagcg gctgctgcgg ggctgtcata gccggcaggc gtttggcagg,101040 gcagaaggca cagtaagagg aagagaggca gcctgcgggc ttggcttggg acagcctctc 101100 taaggctcgt gctgactctc gagcagttcc agctcagcag gccatgcaca cgaaccagga 101160 agctgggtgg actgggctgg gaaggaggcc atgggctcag gagcccggga gatctggtcc 101220 cagtgcccag tggggattct gggcaagcca attcctctcc aggcatctgt gcgggtcagc 101280 gccacacgga agcccctcgt ccctgttgat cttcactgta gagggagagg cagggaaagg 101340 cttgggagat gccgggctgg gatgggctag gggcttggaa tgcctgccca gaggttttca 101400 gggcggcatc tcagcaagtg tccacagtgt gcagagctct cccaggcagg atgggcacct 101460 atacatgcat gcatatgtgt actttacatg ttatatgtaa tacaatgtaa tacatgttat 101520 tttgctcggt tcccacttcc ccttttagaa gccagttgat atataatgag ttggtgtcct 101580 cccattcttt ttgatgcatt gaggatccta agtctgtgcc ccagtcccca tagtctgttc 101640 acttcctggc ttcctggaag aacaaaatgt ccccgcctcc tctcgttctt tccctgcccc 101700 actcctagaa tcagctgttt ttctaaggag cccaggtttt cttccctgag aaatgctatt 101760 tgggtggggg agagggaggg aagcaacaag ctgtggggga agagcctcga tctgggcaac 101820 ccctttgctc ttgtgacctc gagcaagtcc ctcggggcat taggggacca gttatgtcct 101880 ttctagactc acctgaggcc aagaagatgt gggaaacatc catcctgtgt gcctgcggtc 101940 tggaaaggca cagccccagc tctgcccctg tgtggctgtg tgattctggg tttcttaacc 102000 tctctgagcc tcagagtccc catctgtgag ataggaataa catgaggctt tttttttttt 102060 tttttttttt ttttaagaca gggtcttact ctcttgccca ggctgaagtg caatgacatg 102120 atcatagctc attgcaacct tgaactcctg ggttcaagtg atcctcccga ctcagcctct 102180 caaagtgcta ggattacagg catgagccac tgcatctggc acgtggacat ttctgactta 102240 tctcaactag ggaaggtact caataaatgc taattccctt cttcctcccc ttaattattt 102300 gacttcagta ccccaggaaa tgaggactgg gatattggat ggtttgggag aggaggaaag 102360 aggtgtccag ggaaaaggaa gaaattggga aatagaagac cacggacaaa taaaagagga 102420 ggggttaatt cagaataggg aagacgggcc aggcgcaggg gctcacacct gtaatcccag 102480 cactttggga agccgagaca ggcggatcac gaggtcagga gttcgagacc agccttgcca 102540 atatggtgaa accccgtctc tactaaaaat acaaaaatta cctgggcgtg gtggcactca 102600 actgtagtcc cagctgctca ggaggctgag gcagaagaat cgcttgaacc tgggaggcgg 102660 aggttgcagt gagctgagat cgtgtcactg cactccagcc tgggcaacag agcaagactc 102720 catctcaaaa ataaaaaaaa agaaaagaaa agaatagaga agatgatttt aatcatcaga 102780 gctttccaat aaaggcaggc tctggctgct tgggggaggt tgagagcctc ctgtcattag 102840 aggtatgcaa gtagaggctg agggattgtg agccacacag atgtgtttgt gaggactcgc 102900 aatggccagg aggtagattc cttcactcag caaactttgg gagagggctg tccttgcctg 102960 gtcctgtaat ggggcaggga agccaaggtg aataggacac catccctggc cccagggagc 103020 gcccagccca ggaaataagc aaatcgctga gatcctttta ctctgcagtt ctgtgctttg 103080 aagcatccaa gccttggagg gagttggctg gggattttca gtgtgcgcct tttggtattg 103140 atccactgaa gttggagctg gctggggaat ggcaggagga cgccgcagtg ttattagtgc 103200 ggaggacacg ctgtaatctg tcagtgtcac cccggttgca gctggccagg aaccatcctg 103260 ctgttaacgc ctcccttccc agcagccatg gagcacacaa cttgtacagc acctgccagt 103320 gcctccacct ctccttgtag gagggagagt gtggatattt attctttttc tgcatctccc 103380 tagcatgagt cctcgtctcc aatcacacta atttattcag tgttttccaa cacaccttgg 103440 gcattcctac ctctgtacct tcagttacca gaattcccta ccagcggtgg tcactcctgt 103500 ccattcatcc atccacctgt ccatccatcc aatcatccat ccatccaccc acctatccat 103560 tcaatcatcc atccattcat ccgtcatcca tccatccccc cattcatcca ttcaatcatc 103620 catccatcca ttcatccatc cacccaccca ccttccatcc attcaacttt gcaatccgct 103680 tcagttcaat tcaattcaat tcacctttat tcaactcata aggttactgg gctttgccat 103740 gtaccacaca catgtgataa gtgaggcatg cctctgccct caaggagccc atgggaagaa 103800 tcctccccat tctccatggc cagctttgca tctcacctct gttaatcctt tgccatgccc 103860 ttcagcagaa gcaacggact ctgaagggct gtcctgtgag gagagttcag ttctggcttt 103920 catgaattgc agaggacaga gctcagacaa ggagagaggc aaagggtggg gaggaggtga 103980 gagtgagatg agctagtggg acggggattt tggctttgtg gagggagctg cttccagtta 104040 gctgtgagta ctcagcagtg tattggggga tgaagggaaa gagaaggggg caaggaaacc 104100 actattggag aagtgggtta gtgtggcggt gaggaggtga gctctgcagc caatggacta 104160 cctggcttat tgtctcagct ccaccatatt cctgctgtgt gaacctgggc acatatctta 104220 acatctctga gcctccatgt cctcatttgt aaaatgagga taataagacc tatctcacaa 104280 tgttgccttt agcattaaca catgcagtgc ttaaattaat gcgtggcaca aagggagagc 104340 ttaatagatt ccagctttgg ttgtgactac tcctattacg taccagctac tatgccagga 104400 gctttcattc cagtgtgtcc tctgagctaa ccctatgcgg ggattattga acccattttg 104460 cagatgagga aatgaagacc gacggaagct atctcttgag ctcgtcatgc agctggcgaa 104520 gggtggagca gggcttcaaa tgcagacctt tccaactcca ttgtccctgc tctcctgcgt 104580 gccctttcct gccttttctc aaggggtgag tgctctgaga tgcaaagatt ggaagacttc 104640 catcccagct tctgcctagg gcactctttt ggccttctct agttgtagcc ctgaattgtt 104700 aattactgtt tcatgtatgt tttctctgct ccccagagac catgagatca agaaaaaaga 104760 ttttcttctc cacggcaact gaagtgttga ctttgacagt gaaagctaca gagtgtatga 104820 tgtttccctt tttgccttgc ttgccaggaa gcttgtgctt tttgtcaaac tgcttacttc 104880 ccctttccat ggttttggtc ttctaccttt gacagacttt tattcataag tcttactgta 104940 agctgttcta ctcatagaat aagctgaata aatagaaatt gaattgaatg gaaaaggatg 105000 ggttacaaat tacaagtaaa taattcattt tatatttaat ttaatttatt tatttacttt 105060 tgagatggaa tactgctgtc acccaggctg gagtgcaatg tcgtgatctc actgcaacct 105120 gcgcctcctg agtttaagtg attctcccgc ctcagcctcc caagtagctg ggattacagg 105180 tgcccatgcc tggctaattt ttgtattttt agtagagatg gggtttcacc atgttggcca 105240 ggctggtctc gaactcctga cctcaggtga tccatccgcc ttggcctccc gagtgctggg 105300 attacagatg tgagccactg tgcccggcct gcaagtaaat aattcaaata aaatcacgag 105360 cttcaggaaa gaaaaatgcc tttcttatat cgggccattg ccacagtgtt tagccctgag 105420 ccctggttct ggctgggtga agtttgcatg gaaagcccag tggtgatttt ccctgttgtg 105480 tctggatcag tggctctcct tgcacctaga atataactca aaggccttcc ctttggatta 105540 gagcagcagt ccccgacctt tttggcacca gggatcagtt tcatggaaga caatttttcc 105600 acatactggg tgggaaactg tttctcctca catcatcagg cattagttag agtctcataa 105660 ggaacaggca acctagatct ctctcatgca cagttcacag taggactcat cctcctgtga 105720 gtatctaatg ctgccgctga tgtgacagga ggtggagctc aggtggtaat tctccatcac 105780 ccgctgctca cctcctgctg tgtggccctg gtccaaggcc cagggattgg ggaccccggg 105840 attagaggac tgacccctgc ccacctcttc caccttatcc tgtgtaactt gtccccttgc 105900 tcacccagga taactactgg agtcatcttt gagatgttct cacaagccag gttctttccc 105960 tgcttcagaa aagaggcttt gtggctgggc gtggtggctc acacctgtaa tcccagcact 106020 ttgggaggcc gaggcaggcg aaccacctga ggtcaggagt tcgagaccag cctgaccaac 106080 atagagaaac ccggtcttta ctaaaaatac aaaattagct gggagtagtg gcacaagcct 106140 gtaataccag ctactcgggg aggctgaggc aggagaatca cttgaacccg ggaggcagag 106200 gtggtggtga gctgagatca tgccattgct ctccagcctg ggcaacaaga gcaaaaacta 106260 cgtctcaaaa aaaaaaaaaa aaaagaaaaa gaggctttgc atgtgccgtt ccctctgcct 106320 ggagccctct gctctctccc atcccctgct tctgcctggc tcatcattcc tacgcttcaa 106380 atttctgctg aaagtcagca tcttagggag gcctcccctg actgctctgt ttaaaggggt 106440 tgtggtagct ggtctgcaaa gacaactccc agtgcttcct ggcctctcct gtgtatgctg 106500 ctgttcccat caagaaacag actctatttc tcctcctcct ggaagtgggc cgggcgttgg 106560 gcctggcttt ggccaatgga atgtggcaga ggtaatttac tgaggcttcc gaggtgaggc 106620 cttcagatga ctggcagctt ctccttcctg ccacctggaa cccagctggt atgctgtggg 106680 aagcccatat cacatagaga gacacagcgg gagaaatggg gtgttcagct caacagccca 106740 gttgaacccc cagccaacag tcagcatgga ttccagccat gtgcgtgagc cagcctgggt 106800 gctgcagccc aggtgagccc ctgaatgact gcaggcccag ctaacatcat acggaacaga 106860 agaaccaccc aactgagccc acagaactgt gggagataat aaaatggtat tgctgtttta 106920 agccactgaa tttccagtca tctaaagaga ggttaatccc tgataaattt ctctctttct 106980 ctctctctct cttttttttt ttttttagag agacaagttc tcactacgtt gcccagactg 107040 gagtgcagtg actgttcaca agtgcaatca tagtgcactg cagcctcgaa ctcctagtct 107100 caagcatccc tcctgcctca gcctcctggg tagctgatat tctaaaaatc attgccccaa 107160 tgcacttact tcatagcatt cacaataatc tataattata taattatttg attcttaact 107220 tgctaatttt cccttttttc tttttctttt tcttttcttt tctttttttt tttttttgag 107280 acagtctcgc tctgttgccc aggctggagt gcagtggcat ggtcttggct cactgcaatc 107340 tccacctctt gcattcaagc aattttcctg cctcagcctc ccgagtagct gggattacag 107400 gcatgcgcca tcatgcccgg ctaatttttt gtatttttag tagagatggg gtttcaccac 107460 gttggccagg ctggtttcaa actcctgact tcatgataca tctgcctcag cctcccaaag 107520 tactggaatt acaggcgtga gccaccgcac ctggccaatt ttccctttct tcctatagca 107580 catgagttac agaaggctgg gaccatgttt gtcttgattg cagctatccc cagcattaag 107640 cacagtgaat ggcatgtggt gggagctgaa agaatgaaag aatgaatgaa tgaatgaatg 107700 aatgaatgca aggcatcgga gtggtcttga agtgttccta agagccagtg taagtctctg 107760 tggctgcagc ccaggctgat atagcaccag aaaggagatg ggtatggcct aagtctcagt 107820 tctctggggc tttcacgact cagaactgta caacactccc tgacaccacc tctataaccc 107880 agatctccac acccctgcca ggaagaatca cccttttcct tctccttgcc cttctgtatc 107940 ctgcacagct ctccattagg ggacccgaca ggtctccgcg catgctcgtg tgtatagatg 108000 atggaagcag gacagaataa tgggtatgaa tgagggctct ggatccagag acccccacct 108060 ttgaacccca gtccaccaca ttctaaggat atcttggtgc catggctaca gatattgagt 108120 gttcactcac ataggaagtg ctgtgtaagt gtgagcttac attacaattg ccatgtgcca 108180 ggcactactc tcacgtcttg aattcattta cttcatacaa ccttataagg tggttgctat 108240 tatcattccc ctcttacaga tgaggcaact gacgtgtgga taatttgccc aaagttgcgg 108300 atctgaaccc tgccaatgtg gctacagagc ccaccttctt cttttttttt tttgagacgg 108360 ggtctctctc tgttgcccag gttggagcgc agtgatgcaa tcatggctca ctgcagcctt 108420 gaactcctgg gctcaagtga ctcttccatc tcatcctccc aagtagctag gactgaaggc 108480 gtgcaccacc atgcccagct aatttttgta ttttttgtag agacagggtt tcaccatgtt 108540 .
gcccagcctg gtctcaaact cctgagctgg cgtgatccac ccagcttggc ctcctaaagt 108600 tctgggacta cagccgtgag ccaccgtgcc tggtccagag cccaccttct taaccctcat 108660 actgcctctc tcgttctcaa ggtagaaccc tcgttctgcc tccctgagcc tcagttttca 108720 tacctataaa tgggataata atgcctgttt aatagggcta tgataccatg atctggcagt 108780 gcctgacaca ttgtagaatc tcaataaatc ccaatttgct gtggcaagat agatgaacag 108840 acttccaaac caaggagggc tttgaagctt tactgtgagg gtgctagaga accactgaaa 108900 gttttcgagt aagacaatga catagtgaag ctgtggctta gctccagtcc taccttttcc 108960 cgcctctgtc cccccaacaa ttagctctat gctgcctgag gttggtatct gagtttcaca 109020 tccctgtctt acctccccgt gaggtgctga gatttgaact gtttcaggat cgtgatagtt 109080 catcccgggc ctggaatgaa tggggtggga gggatgttct tgatcttgtg ggactcatct 109140 caaagggctg cctcagagat cccatctggg gccccatttc tgtctccacc tccagcccta 109200 ctgactgaca gaggtgcctg ggtttcatat gactgacttc gtattcccct tggaatccct 109260 tctgcagcat agtggatgag gtgagacaga ggctggtaac tcggtggaag agagaggagg 109320 gagaaaaaac aagggagcca gaacaggaga gagtgggaga cagggggaca gagagagaga 109380 gtggtggaga gagggcgagc cagagtgagg gaaagatggg ctcactgctt cagggcgggg 109440 tgcacctggt gacagaaatg ggccacctga ccttgtgctg tgttcccttg ttctgacaga 109500 tatggtgagg ccatctgacc ttgtgctgtg ttcccttgtt ctgatggatg ttgtgagtct 109560 gtgtgggtgc acaagcatgc acatgtggtc tgtgtgtcca catagatgcg agcgtctgtg 109620 acatagcatg caccctgtct gctggcctgt gcatggaagt gcacagatgg gtctccaagg 109680 acctagggac taagcatgtg gagaaccatg tgcagtgcct atgtacgtcc tcagccccag 109740 cgtcacctcc tccatgtgcc tcacccccta ttcgttcacc ctcctccccc tgtggtggca 109800 ttatcacctt tcttggtcag tctctgctta cctgtccctg tctctgcctc tattgagagc 109860 ttcctgcagg aaagtccaca tccttgtcat ccctgtactc ttggcagcaa gatcaaggct 109920 tgctggggca ggtgatcaat aaaggctgat gactgattga gtatatttgt gtgaatggat 109980 ctacttccag aagcgtgtgt gggtgtgtat gtgtgtgtgt gcacgcacat gtgcacacat 110040 ggaaacatgt atgtggccat acacaaatgc acatgcactg tggggtgtgg atgtgtctct 110100 gagatgtcca tgaatgagcc tctgggcaca caccatgccc acagattgat gcagtgatat 110160 gctggcaaat gtttaacaac cggctcttca ttgaaaaaaa gaatgctgtt gggccgggcg 110220 aagtggctca ccctgtaatc ccagcacttt gggagtctaa ggtgggcgga tcatgaggtc 110280 aagagatcga gaccatcctg gccaacatgg tgaaacccca tctctactaa aaatacaaaa 110340 attagctggg tgtggtggcg cacacctgtg gtcccagcta cttgggaggc tgaggcggga 110400 gaatcacttg aacctgggag gcggaggtag cagtgagcca agatctcatc actgcactcc 110460 agcttggtga cagagtgaga ctctgtctca aaaaaaaaaa aaaaagaaaa gaaaagaaaa 110520 ggaaaaataa gccctgatta gcagcatttg cccattgctg tagtgtaaat gttcccacca 110580 tggccgactt caagttgctg ctgtggcgtc atggaatatg gagttagctg ggaagagatg 110640 cacataactg gctcacatga gcccacagga gttggcttca gtacacggaa gtattcatgt 110700 ctgtgactgc ccagcccatg atgggcaggg gaggcagtgc aaagttcccc tggtgatggt 110760 aatgcttctt tccagagctg tgccctgggg gagcaggcag ttgctggctg ccagccagct 110820 ttcaccaagc ggccttagaa gtcagtctaa accaatactc cttgttaggc aggtctaggc 110880 gctcaccaac acagcagcac cttccctcac tccctgcaga ggctttgaag tttttggatt 110940 tggtgaagtc agcatgactg caaggaggaa ttgctaagcc tgaagcatga atggaagagg 111000 gggaaggagg aacgcttcaa acctccatct gaggcaggtg gccagggatg ctggaaggtc 111060 tggaggccct gggccttgtg cctgcttgaa gccgattcac tgtgtaagcc tggacacatc 111120 gcttgccctt gctggcctcc acctgtgact tccgtgaagg gagaggtctt ctgagctccg 111180 tggcctctac ctgaccctct gggagttggt ccttaaactg cgctctgagt gttaaaatct 111240 acattcaaaa ggcagagaga ggctgtgttg gccttaaaca agagcaagag gggaccctgc 111300 cctggccctc ctcagaccag gccctttccc acatggtgag gaattcacag gccaaggcga 111360 tgtgctcacc ccaagcccta ccctttgcta gacactcgtc tgatgcctgc tgctgtagaa 111420 tttctgctcc aagagtcctg ccgtgctggc ttccagggct ggctgccatc tgtcctcctg 111480 aggacccatg tcctcctgcc ttaagcagtg gttttgggaa agctgggtgt gcaggctggg 111540 atgtgtgccc actttgtggg agatgccctg aacgtgctga gtggagctgg aagtgggaaa 111600 ggaggagggg tgggtcatgg gcagggagct gtggtcttgg gttccagggt gggcttgccc 111660 catgctgcta ctttgaggag cagaatgcag aggaggttga gaattctaaa ttcaaaccta 111720 acattttagt ttgtcacaag gacatatttg ccaggacaga ggatagacca tatttttaaa 111780 ttttatttta tattttattt taattttttt tgagatagag tctcgctctg tcacccaggc 111840 tggagtgcag tggcgcgatc tcggctcact gtaacctctg cctcccgggt tcaagcaatt 111900 ctctgcctca gtctaccgag tagctgggat tgcaggcgcc caccaccacg ctcggctaat 111960 ttttgtgttt ttagtagaga cgggatttca tcatctcggc caggccggtc ttgaactcct 112020 gacctcatga tccaccttcc tcggcctccc aaagtgctgg gattacaggg gtgagccacc 112080 tcgcctggct gatagaccat tttttaaggt cgttagttcg atgtgcagct gttaaatctt 112140 cagacttaag ttatggagag tgagcctccc tttctactct tgccctggac cccacaagtg 112200 ttaggggtga gcctggagag agagataatt gagattggtg ggggcttggt ggtgtggccc 112260 cagcagactg aggctgagtt gaacagggag ttttgaacat tggacccttc tagagtagac 112320 ttttccgggc cacgtcatac agggcttacc ttctcttagg tctgtgcggt gtgtaggtgt 112380 catctgcttg ccatctcctt tctctggagc cccaggagag ctgtacagtg agtatgcttc 112440 cccaacacat cttagatagc actgttatct tagacagctg ttttggggca tgacaggtca 112500 tccttccaat ggggcctttc tctgatgtca aaggtcaaat cctcctgtta gcattccatc 112560 ttgtctttct catctcttca agttaagaga gtcccaggga ccctccccat tcttctgcca 112620 ctccatggct ctcctcttcc tgagaagcac ccctctgcag ggagccccct gagtaaactg 112680 gtagggtcat gtccattcca aactgcacaa tttcacgggg gaaaatggaa accctggagt 112740 gtaactggga tgttgagtgg ggctgcttta ttctaaaaga taaaactcaa ggacgtcatg 112800 ctctctgtct tcaaatatct gaggggctgt catgctgaaa agggaaggga tttattcagt 112860 gttgttggag tgtgaaggaa gaggtggatt aaaattcagt gtgcagagaa gacttttgcc 112920 aaagagtgct gcttagcact ggctggtgct atctttggag ggggtgagcc cgctgtcact 112980 ggaggcgtgc aagtatccct aaaggatatt taatagggaa ctcatgatct agagagtggg 113040 gggacaccct actgtacagc atctaaacct ctcatcccca ataatctgta gctttaggat 113100 tgttttaaat aggatgccag gagttgggaa aggaattaaa gaaattcact gaagtgagga 113160 ccaagctata aaaaaaaaaa atctttattt catgtaccag gatttttttt ttcagttttc 113220 tgctttttaa aatttttttt ctgttaacag tctgaaaaaa aaaaaaagga ctcaccaaga 113280 aaataaatgg aggttagttt cttgaactgg tctgagctgg acatgagcaa tcatccacac 113340 ccctgggcag caacgccctt gcagttccgg tcctggctcc ttccctccgg accccctagc 113400 cccttctcag ccatggcgat gtcaccccac accccagtgg ctttcttcaa gcacacccag 113460 aacccaggcc ttgcgccatg gaaagaagca ctgatcgcct tcccagacgc tctgccagaa 113520 ttcggagaac tggagctagt ttttctcttc agacagtgct cgcttgggtg cggttttctt 113580 ggggaccctc ccttctccct tcgctctcat ccttgatccc tttaggtctg gaatctggtg 113640 ggatggcggg caagattggg gtgggagagg ggtagagttc agtttctgcc cagactgagg 113700 gcaacttggt tgttgttacc acaccttgaa ttgtctccca ttgttctgcc ccagggccca 113760 tgacctcccc ctgtacttct gggctgggct ggccgatgtt ctgccccttg ctgacctggg 113820 aaaataactt tcctttccca ggcaaaagac aggaaaggca ggtgagatgt gcaagctcaa 113880 aaagccttac tagccattct ctagaactcc ccagagagct caacctcagg aaatgccggt 113940 gtcaagaaaa atgcaaaccg ggggagactc gcaggcagag gcaggggggc ctcaccttga 114000 ccttcagtca cctgggagta acttgcagac tgttctgaaa tttccagctc aggaaagctg 114060 ttggatttct gtcagtctga actggccctt gtcactctgg ggaagaaagg ggagaaacac 114120 aggatgccct tgacctttag tctgtggtgc aagtttaact tttggggttg gtccttacac 114180 tgggatggaa ctgctaaaat tttcctctcc attccctcag ccttgagccc tcccagtaaa 114240 cctcagagga tcctcttttt cacagacccc caaagacact ggggaagccc tggtggcaga 114300 gctcttctcc caaggaagcc tctttaactc tccatgatcg cagcaagggg acacaaagtg 114360 aagaagggct ttggggaccc ctgcgtcttt cccctctttg cctgaacagc tttatgtttg 114420 ctcacatgtg tgtatttttg ctttgacatt ggatgtgggg gcaggtgttc ggggagcaca 114480 gtgaggaggt atatggtgtg tgtgtgtgtg tgtgtctgag aggctgactg atgatgagcc 114540 tgggggcttg gtggcagctg tcctggtcat ccctggcata tcctcggggc aggtggcaga 114600 tcttaagtca cagatacata gagcaagaat gggcctttag tgcttctctg ggtcaatcca 114660 catgcttaca tggggggaaa attaaggccc agagaggcca tgcagcaagg aattccggaa 114720 tccagtcctg gattctagac gggtgccctt cccatgcatg cgagtggtgt gtgtgtgtgt 114780 gtgggtatgt gtgcgtgtgt gggtatgtgt gcatgtgtgt gttcatgtgt atgctctgtt 114840 gggaggttgt gaatgaacac aaaggccagt gtggagttgt tgtcgtccat ggctttggag 114900 ggcatgagtc aatttccttt gagccacgcc cctggccgtg tatgggatgg aagggttgag 114960 actgagtgtg tccctgtgag tgactgcagt gctgggctaa gtggactgtg tatgtgtgtg 115020 tgaacgtgcc tgtgtgcgtg tggggtgtgt ggtctctttc tttgttggat tctgtcttcc 115080 cccattcgca gcaccttcct tgtctgagga agccaccttt ccatcacaga gaccccctgc 115140 agctcactgg gaccttccgc tactccctcc aaccttcaag cccagctctc acctctcaca 115200 acggttttgc tttgtttttg taaatggatt tgtatattcg ttttctgttt tttttttctt 115260 tacaagttcc ctgctaaagt ttaagtcccc caccccgccc cattttttgt tttcacagtt 115320 taaagctgga aaagaattaa aagaaaaata ctatctgatt ttcttgcaag taaatccact 115380 tattttgtat ttacatttat ttatagtctg tggttttttt attaaaaaaa aatcaccact 115440 tgtttttcct ttttcttttg taaaaagaag cctttttgca gtgtcattgt tgaacccgct 115500 gggccccaag ggggcatcag tgagtccaag gacccccaaa gggtcaatga acccccttcc 115560 caggggactg gggggcttat gagtcagggg gtccaccatc gccccagggt catcaggtgg 115620 ccctgaggtg aggggtgagg agggagagct gtttcatgtc ccccgggggg gggggtggca 115680 tctcctgacc ccaaggacag gagcttgggg acatgacccc aagaggctca ccctgaggat 115740 tccggggttt ccggcatett ggtaagccac cggcagcctc ccctctcctt ccctttcctc 115800 aaggcctagg aagtcatcac agtgggttaa ggagcattaa ggactgggaa cctggggcca 115860 ggcaagcccc aagtgtaccc ccctccaggc accctaacgg agaggaggga caagggctcg 115920 gtcacctgga ggcctacgat tgccccatca~atgctgggcg gagccggctc gagctctgag 115980 ccttcctgga gttcctgggg cacccaccca ggggctccag ggacctggca gtgactgcag 116040 gctcacctgg ccccagggcc cctgagtctc gccccccaat ctcccaggga ggcagggccc 116100 gctgggggtt aaagggaaca gaaaagtaac tctccccgag ttaaaaaaaa aaaaaaaaag 116160 taacataaac cctgaaaaat acaaaggaca tcccctttcc tttctgttct catttttttt 116220 ttttttgctt taatgttatc ttggttccct tttatttttt catttaaatt gatttttatt 116280 aaatgttaaa ataatggtac atgggaaatc atgcattttc ttttagattt attttctatt 116340 tttaattttt tatccctctc gctttttttt aaagtttgtt ttcttccctc gtttatattt 116400 tcccacattt cctgttgttt tgcttctttg ttcctcttat attttgttct tttttttaaa 116460 atttacttgt tatgtttttt ctcttttttt gtgtgtgtgt gtttttttgt tttttgtttt 116520 tttgtttttt ttgttttttg tttttgcttt tggaaggtct cccagcggag ggtctgggtc 116580 tccccgcccc gccccgcccc cggggaccgc gccctcctcc cgcggtcttc tggcgaggcc 116640 cgcggtcttt atacgggggt ggtccggcgg ttggctgtgt tggagtggag agagtccttg 116700 ttctccttct ggatacagtt gtgaacctgg aggaagctgt tatccctgtc ggagttgtag 116760 gtggcggtgg gcgtggtggc ggccttcagg gggtccctgc tgagcgtgta catggagatc 116820 tccgtggacg gcagggtgtt gaagcccttg atgcccacgg gggaggcgtc cctggagtgt 116880 gagggctccg tggagcgcga gctggagcgg ctgcggcgct ggtagcggta gcggtagctg 116940 gggatgcggg tgatggcaga ggcctggagg tagtccgtgg cgcgggccgt ggcccgcagc 117000 tgtttgtgcc ggtcgataaa catgtgcacc gccagcaccc cgaccatctc ggcgatgatg 117060 aaggacaggg ccccgaagta gaaggaccag ccgtatgagt aactattctt tttggagtcg 117120 ctcttggagg ggtctccggc attggcagat atgtacacta tgatgccaat gatgttactc 117180 agacctgcgg ggcgcagggt ggcggggtgg gggatcagag agaaggacgt tagtttctca 117240 ggaagtcggc cacagggcag ccgtaaagga cggggacagc tgtgtgggcc ttccccggtc 117300 ccgcgccttc atgaacaggt ggggcggtgt agatggacat ccgcaagctt ccccttaaca 117360 ttttatcttt ccattcagag agagccacaa gggaagcgct aatggaaaca gacatgggca 117420 gggcgggaga agggaggcat ttcacaaggc gctgagtaac taataataga tattgttcat 117480 tgagccttct ctacctgctt tcactgcttg gtgcttctca agcagggcac agatgaggaa 117540 acaagcacag agaggttaag gaacttgctt aaggctgcac agggcttcaa agctggtgta 117600 gcagcgggtg aaggcgggct gatggagcca ggctggcctg cgttcaaagc cttcgcaagt 117660 taaccttggt ttgagtttcc agatctgtag aatgggagta aggttaagcc ttactcttta 117720 gggccacgga gagggttaaa tgggtgaata catgtgagta ctcttagatg ttggtggttc 117780 cttttttttt ttttaagata cagtcttgct ctgtcaccca ggctggagtg cagtggtgtg 117840 atcacagctc actgcagtct caaactcctg ggatcaagcg atcctcccac cttagcctct 117900 ctagtagctg ggattatgta tgcgtcacca tgcccagctg attaaaataa aaaaatttct 117960 gtagagacgc ggtcttgagg cctcgctgtg ttgcccaggc tggtctcgga ctcctgagct 118020 caagtgatcc tcctgtctca gcctcccaaa gtgctgggat tgcaggcgtg agccactgca 118080 cccggcctga tgttggtcat tcttattaaa tggctcaggc tacacccagg ttctttttct 118140 ggcatctgaa gtgagtgtga ctcatctgtc atgtaactgg gctcagacat ctggatgtgg 118200 gtgcctgcct gctcccacct gagtagaaca gtgaggggag agtccaccct tggtttccaa 118260 ggtgaagctg agtatcccat aggggttgga acagcgaggc acttgggtgc cctctctcca 118320 gcctcctcat gggtttactt gcaccgggaa gggaaagggt aagtggcaat tggccaagta 118380 ccctgagagg aagcgggcat ttgggccttt tctcaagtgg tgggaagaag atggggtgtg 118440 gggatgctcc tggaggattt ggtacaggct cgggagttgc tacaggacag gagccccccc 118500 accaccttcc tcccctgcaa cacgacctag tgcaagtctt ggagatttcc tctcctctct 118560 ccccatctct ctctgccagg ccctcgtggc ccctgagcac ccacacccca gccttcttcc 118620 cagtggcagg actggatcag tggctgttac ctgcagacac gaagaagatg ccggcactca 118680 ggatgatgtt gtgtcgagtt ttgtagaact cgctggctgc gatgcagagg ccacccatga 118790 aaagcagaat cacactcagg attgggaaaa tgctggaggc cctcacggcc cctgtggaac 118800 acagagggtc agggagaaag agaacggcat ggctgtgaga ctgaggcaca cagaggcagg 118860 tgggagagca gccccgaggc gctgggggtt tatggacaca gccttagagg agaggttgct 118920 ttgcaatcct agggagggag agacagcgag caggccactg cccagctcac agccctgcag 118980 gagctcccca ctgcctccag ggccaaactc cagcacaccg tcaggcacac agggccctgt 119040 gtgacttggc ctctgcccac ttccagctcc cacggctccc agtcctcatg ttctctctcg 119100 tcccaccaca tcaaacttcc cacgacatgt catttcatgc tgctgacttt tgaaatacag 119160 agcttcctac tggaatgtct ttcctattct tcactcagca aactcttctt catccttcaa 119220 aacccagctc gaagtcccct cttctgtaaa gccttccctg acttccttag gcaaagttat 119280 gagctccctc gtctgcactt tggggccctt gggcacgctg agaggcagtg tggtatagtg 119340 gttaggtgga accacgtggg ttggatttga gtctggctgc agcatttatt agctgtgcaa 119400 tagaaaaagt atctcacctc tgtgtgcctc agtttcctca tctgtaaagc agggatggta 119460 ataatgccaa gctcctaaga ttgttgtgag gattaaatga gttgattcag gcaatgcact 119520 tagataagtt tctggtgtct ataataaaca ttcaatgcat gatattataa taaatatttg 119580 tgtatacata tgcttccacc atgaaccatg ggtcgtgaga caaggactgt ggctttacaa 119640 agaaaaagtt tcttgtcttt atcctctctg ttcaacgaca cagtagtctg ccaatagaag 119700 ctcattaagt gaataaatgt ggggtcgtgg tccagaagga aggaacaggc acattgcaaa 119760 gaaaacaaag taagaagaga aaeccctcta gataaggact gacaaacagg accggagaag 119820 aaaagaatat ggtaatgaaa agggagaaac agaaggtgag ggccagggct cctacagttg 119880 ggggtggatg ggggaaaagg gggacaggtg gctaagggca gaggtcgggg ctacatgtgt 119940 ttgtgggggg agcagcacct gaatgaggac ccagaggtgt tggggagccc ttcacaaagt 120000 gtctttgcga agtaaaacat ttttttttta atccaaattc aaataggcag tgagtgacct 120060 caggacccag ctccgtgtcc tgggagccat gggctaggca ggaggcagag ctggcttgag 120120 gcaggggtga gggaaaatat gtcttcttta ttattattat tttttgagac ggagtcttcc 120180 cctgtcaccc aggctggagt gcagtggtgc aatctcggct cactgcaact tctgcctcct 120240 gggttcaagt gattctcctg cctcagcctc ccaagtagct gggactacag gcgtgtacca 120300 ccatgcttgg ctaatttttg tacttttagt agagatgggg tttcactatg ttggccaggc 120360 tggtctcaaa ctcttgacct catgatctgc ccaccttggc ctcccaaagt gctgggatta 120420 caggcttgag ccaccgtgcc tggccaaaga tgtcttcttt aaatggtgct taagtggttt 120480 ctaaggaagt tgagtcctga taattacagg accctttggc caagcccagg gattggtcag 120540 ggaggttggt tttggagggg aatgtgccag gagcggagct tcctcttatc cccatccccg 120600 tccccaccct tttgggtggg agtgtgttca agaaggatct gtgagaagag aatttctcta 120660 tatagaactg tagggatttt tctttttctt ttttaaaatt tatttttatt tttatttttt 120720 gagatggagt cttgctctgt tgcccaggct ggagtgtagt ggtgtgatct cggctcactg 120780 cagcctccac ctcccaggtt caagcgattc tcctgcctca gcctcccaag taggtgggac 120840 tacaggtgtg cgccatcaca cctggctagt ttttgtattt ttagtagaga cggggtttcg 120900 ctatgttggc caggctggtc ttgaactcct gacctcaagt gatctgcccg cctcggcctc 120960 ccaaagtgct gggattacag gcgttaaaag gggattttag gcagtttgct gagatgtgtg 121020 tgatgtgaaa actcttcttc tgtcctcacc atggatctgc agcatagtct acactgctca 121080 caaatgggtg agtgggttat ttggggggga cctgaagaag ggcagggctc ttggggcaaa 121140 actgagctgc atatagggaa gcaggggtgg gaggatgggg gcttggggtg gctgggctac 121200 tctgcagcct cagcaccctc cttctcttgg gcgggatggg gctgctcctc cacagacccc 121260 agggaggtgt tctctccttg caaatcattg ctaagacaac acgctgtatc cctaacctga 121320 tcccccagcc caaacacacc cacatccaca cccacgcgtg acagacatgc atgactaaaa 121380 agccacctta actctcatct ttataagcac atgaggatgg tgagagctta ctgaaaaccc 121440 aggagaagag agagaatatt tgttaaacac ccattcggtg ttgggtcttg agcaggtacc 121500 taacatatat gatataattt catcctcata acagtccggc agggtgtgtt tttttgcccc 121560 aatttacaga caagaaaatt gaggttcaga gagagaaact cccctgccac ccagctagtg 121620 aaccaggatt catatccaga ccagctcaac ttttggagca ccctgtagtc tccctatgtg 121680 gcttccaagg agcccaggaa gggtgagtgc cacagggcct ggagaactgg gtttgggtcc 121740 cacctgtgcc actcacttgc tgtgtggcta aggcgggtgc tcacttcctc tgtttttccc 121800 ctgtgtaaca tggggtatgg cctgttagat ggtttctttt tgtttgtttg ttttagatac 121860 agagtcttgc tctatacccc aggctggagt gcagtggcgt gatcttgact cactgcaacc 121920 tccgtcttcg gggttcaagc aattctcctg cctcagcctc ccaagtagct gggattatag 121980 gcgcccgcca ccatgtccgg ctaatttttg tatttttagt agagatgggt tttcgccatg 122040 ttggccaggc tggtctcaaa ctcatgacct caggtgatcc accggcctcg gccttccaaa 122100 gtgctgggat tacaggcctg agccaccgcg cccggccgtt agatagtttc taatagctct 122160 gccctttcca tgtggacatg gtcctggcca gccacaaagg ggaatgacag aagagagaag 122220 gaaagaaaga aagaggtcgg tgtggcttcc gaggcgcagc agcagcagct cagaggaaca 122280 ggcagaagaa aggctctggc cttccccctc caagaaagtg gggtcttact acccacagga 122340 tgcctgcagg tcgccgaccc aattgtgccc tcacagcaaa tggactcaca gcagcccagg 122400 gcttgatttt tccagttgag ccccatctgc tgtgggaacc cggatgcccc agctcagccc 122460 tcctgccagc agggggaggg agcgtcggct gcggagggag ctgggatgca tgcgtgtggg 122520 cagccagagg ccaggcatgt gtggacaaga tggagggcgg cgggagagca gggaggggtc 122580 tgctgtgttg cagccagcaa agagcaatgt ggaggaatca gaacggcttc agaagccacc 122640 aaggcagcgt atgacatgct ctaaataatg accaccagcg gggaatacaa acagaagcct 122700 cttcggcaca gaagagccag ccccaagctc tggcctttcg tggaagaggc ctctttgccc 122760 agaaagaagg caacaggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag 122820 gcagaggtgg gtggatcacc tgaggtcagg agttcgagac cagcctggct aacatggtga 122880 aaccccgtct ctactgaaaa aaacacaaaa attagccggg catggtggtg cgtgtcagta 122940 gtctcagcta ctgggggtgc tgaggcagga agatagcttc aacttggga.g gcggaggttg 123000 cagtgagctg agatcgcgcc actgcacccc agcctgggca acagagcaag actccatctc 123060 aaaaaaaaaa aaaaaaaaaa aggcaacagt gggcaaccag caaatagcac catgcttagg 123120 ccactagact tggcagggcc cagatccagg tgggaaggaa gctggtttag gagcaagcag 123180 ggacttctac attggagacg tttcttgaag gaggtatttc tggctgggta gtgtcacaaa 123240 cggaatgggg attttggagt tagtcacact tgactttgaa tcctcgcttt gtcagttatc 123300 aacagtgtga cccttgggca agggtcatta ctgctctgag cctcagtttc cccatcctgt 123360 gaaatgggaa tagtaaaaat aatatttagc ttataggaat gttgtaaggc cttgctgctg 123420 caagtgtggc ctgaggccca gcggcattgg catctgatta gaaaggcagc cctgccaggc 123480 atggtggctc atgcctgtaa tcccagcact ttgggatgct gaggtgagcg gatcacatga 123540 agtcaggagt tcgagaccaa cctggccagc atggcgaaac cttgcttcta ctaaaaatac 123600 aaaaattagc cgggcgtgac ggtaagtgcc tgtaatctca gctacttggg aggctgaggc 123660 aggagaaccg cttgaacccg ggaggcagag gttgcagtaa actgagattt cgccactgca 123720 ctctagcctg ggtgacggag cgaggttcca tctcagaaaa aaagaaaaaa gaaatgccgc 123780 ccctcagctc tttcccccaa ctgagtcata atctccattt taatgagatc cccagagcaa 123840 gatttgcatg catatgaaag tttgagaagt gctgttataa gaattaaatt ggggctgggc 123900 tcggtggctc acacetgtaa tcccagcact ttgggaggcc gaggctggtg gatcacttga 123960 ggtcaggagt tcaagaccag cctagccaat atgatgaaac ctcgtctcta ccaaaaataa 124020 aaaaattagc tgggcatggt ggtgcacacc catagcccca gctacttggg gggctgaggc 124080 aggagaatcg cttgaacgcg ggaggcagag gttgcagtga gccaggatct caccactgca 124140 ctccagcctg ggcgtcacag caagattctg tctcaaaaac aaaaaaaaaa aaaaaaagaa 124200 ttaaattggg tcctaccttt tactgtgtct cacactagaa gttgcacagt aaaaggtagc 124260 aatttttatt tctgaggtcc ctcttcccaa aacatcagtc caggcataac ttccctataa 124320 attgtcctca cttcctacaa agccaagcat ggtcttgttg ccaaaatcta tcacaagagt 124380 caggaaatat ctgatttatt taatgaacaa atatttactg gtctcctatg agtaagcata 124440 tggcacttca cattacctga caacatttat ggagcccctc ccctgtacca ggccttgttc 124500 taagagcggt gtaaacctca taccagcccc atgaagccat gggctttggc ttcaaggaga 124560 ttacacacgc ctaaagctga cactggcaaa cttgttctgt gaagggaaag acagcaaata 124620 ttttcatctt tgctggccat atggtctcag ttgcaatttc ttaactttgc agttgtagca 124680 cataaacagc cataaacaat atgtaaacaa atgaacgtgg ttgtcttcca ataaaacttt 124740 atttacaaaa tcactttggg aggccgaggg ggctggatca cttgaggtca ggagttcgag 124800 accagcatgg ccaatatggc gaaaccccat ctctactaaa aatacaaaaa ttagcccggc 124860 gtggtggcgc atgcctgtag tcccagctac tcgggagccc gaggcaggag aatcgtttga 124920 acccaggagg cagaagttgc agtgagctga gatcaagcca ctgcactcta gcctgggcag 124980 tgggtgacag agtgagtgag actccatctc aaaaaaaaaa aaaaaatcag gtggtgggct 125040 ggatgggctg gatttggcct gctagtcata cttggccagc tgtggccaag agtatactct 125100 atactgggga aaaggccacg tggtccagag cagggagatg ctttgctcta ggctagctgt 125160 gaatccagtg agcaaatatg gactgagtgc ccaccgctgt gctagacctg ggcttggcat 125220 gagagacatg aggggtccaa aacaggcctg gttcatgtct ttctagagct tatactctca 125280 tgaaggacat gtatgccatc agataatcac acagcctgga taacgtgcta tgaaagaaaa 125340 gtacctatat ggcaccatga gggtatgtga caggctaatg tcacatgtag acaactaatg 125400 tccatagaga gcttagagta tgccgaggac tgttttgagc actgcacata cacaaactcg 125460 ttagttctca ttacaactct gtgaagtaag tacttcatat tatttttatt ttttaaattt 125520 attttagttc tacttattgc attatcttaa gcagcatata atagtatggc ctctgaaatg 125580 tgatagacct ggattcaaat ccaatgcttt tgttttttac tttttaatta ttattattat 125640 ttttttgaga cagagtcttg ctctgtcacc caggctggag agcagtggcg tgatctcggc 125700 tcactgtaac ctctgcctcc tgggtttgag tgattcttgt gtctcagcct cccaagtagc 125760 ttagattaca ggccatgtgc catcacacct ggctaatttt tgtattttta gtagagacgg 125820 ggtttcacca tgttggccag cctggtctcg aacttctggc ctcaaatgat atgcctgcct 125880 cagcctccca aagtgccggg agtgcaggcg tgagccacca cacatggcct atataggtat 125940 tttaattatc cccactctac agagaccaaa ctgaagcaag gagaggttaa gccatttgtt 126000 caagatttgt gaatccaggc agtctgactc tagggtctgt gtgtctaacc actgcattcc 126060 cttcttttca ggctctacac tttgctgccc ttcaaagcat cctctgagct tatgtgggga 126120 tcaggacagg tctccctgag gaagtggtgg tagagctgac ctctggcgaa taaggagcag 126180 ctgattaggc acaatgaagg cagggctgtg ggagagagag cagcaggagc cgaaggtgga 126240 ggaggcatgg ctccttcaga gacctggaag aaggctggat cacgaggagc cagtggaaga 126300 gtgtggggag cactgaaggg aggagccagt ggaggagtgt ggggagcacc taaggagagg 126360 aggcaggcgg gtctgggcca cgtggggcct catgagttga gctaaagagc ttagctttat 126420 cccaagagca atgggaaact ttaaagggct tagaacaggc agggctgtca tgatctgatt 126480 tgcatcttaa gaagcaaacg gattacgaag gggtcaaggg tggctccagg gaagcagtga 126540 gaaggctact gcagctgatc ggagaggagt gatgccggtg cttgggccag ggtaggtaca 126600 aagggcatgg acagaggcag atgtgtctga gagatgttta ggaggtgaat tgaagcttga 126660 tggatggata tgggtagtga agagggtggc gttgaggtta acttctaggt ttcagacttg 126720 ccagctgggt ggaaaaaacc acttaggggg actgggagag gacccagcct agcagtgagt 126780 agagagtagg ggaggagcct gggcgaggtg gctcacgcct gtaatcccag cactttggaa 126840 ggctgaggcc ggtggatcac ctgaggtcag gagttcgaaa ccagcctggc caacatggtg 126900 aaaccccatc tctactaaaa aaatacaaaa ttagccaggg gtggtggcgc atccctgtaa 126960 acccagctac ttgggaagct gaggcaggag aattgcttga acctgggagg tggaggttgc 127020 cgtgcaccaa aattgtgcca ttgcactcca gcctgggcaa caagagcgga actctgtctc 127080 aacaaaacaa aacaaaacca aaacaaaaca aaacaaacaa aaaaagagac tagaggagga 127140 agatc 127145 <2l0> 27 <211> 2406 <212> DNA
<213> Human <400> 27 agtttactct acatcatagc agagaaaatg gacaaaacac agctgttttg catgtaggag 60 aatactaaccctgcacagattgtgatggtgatgtggaatatactaaagcctagaacgcac120 ctcctctgcatgactaatatgttctgcacaagacatgaaggcacagacagcactgtcttt180 cttcctcattctcataacatctctgagtggatctcaaggcatattccctttggctttctt240 catttatgttcctatgaatgaacaaatcgtcattggaagacttgatgaagatataattct300 cccttcttcatttgagaggggatccgaagtcgtaatacactggaagtatcaagatagcta360 taaggttcacagttactacaaaggcagtgaccatttggaaagccaagatcccagatatgc420 aaacaggacatcccttttctataatgagattcaaaatgggaatgcgtcgctatttttcag480 aagagtaagccttctggacgaaggaatttacacctgctatgtaggaacagcaattcaagt540 gattacaaacaaagtggtgctaaaggtgggagtttttctcacacccgtgatgaagtatga600 aaagaggaacacaaacagcttcttaatatgcagcgtgttaagtgtttatcctcgtccaat660 tatcacgtggaaaatggacaacacacctatctctgaaaacaacatggaagaaacagggtc720 tttggattctttttctattaacagcccactgaatattacaggatcaaattcatcttatga780 atgtacaattgaaaattcactgctgaagcaaacatggacagggcgctggacgatgaaaga840 tggccttcataaaatgcaaagtgaacacgtttcactctcatgtcaacctgtaaatgatta900 tttttcaccaaaccaagacttcaaagttacttggtccagaatgaaaagtgggactttctc960 tgtcctggcttactatctgagctcctcacaaaatacaattatcaatgaatcccgattctc1020 atggaacaaagagctgataaaccagagtgacttctctatgaatttgatggatcttaatct1080 ttcagacagtggggaatatttatgcaatatttcttcggatgaatatactttacttaccat1140 ccacacagtgcatgtagaaccgagccaagaaacagcttcccataacaaaggcttatggat1200 tttggtgccc tctgcgattt tggcagcttt tctgctgatt tggagcgtaa aatgttgcag 1260 agcccagcta gaagccagga ggagcagaca ccctgctgat ggagcccaac aagaaagatg 1320 ttgtgtccct cctggtgagc gctgtcccag tgcacccgat aatggcgaag aaaatgtgcc 1380 tctttcagga aaagtatagg aaatgagaga agactgtgac aactcatgac ctgcatcctt 1440 aatatccagtgacttcatctcccctttcttcaccacaattccaggcaatggcctgtcgga1500 ccagacaattctaccactgcaaagagttgtaaccattttctggtatcacatttatttttc1560 aagacatacttttcaagacatcattcactgacccactacctgcattgagtataaatgcct1620 ggatgttaaggattccaatttaactttgaaaagaactgtctcattcatttacatttctgt1680 tacagtcagcccaggaggttacagtgagctctccactaagaatctggaagaaatgcatca1740 ctaggggttgattcccaatctgatcaactgataatgggtgagagagcaggtaagagccaa1800 agtcaccttagtggaaaggttaaaaaccagagcctggaaaccaagatgattgatttgaca1860 aggtattttagtctagttttatatgaacggttgtatcagggtaaccaactcgatttggga1920 tgaatcttagggcaccaaagactaagacagtatctttaagattgctagggaaaagggccc1980 tatgtgtcaggcctctgagcccaagccaagcatcgcatcccctgtgatttgcacgtatac2040 atccagatggcctaaagtaactgaagatccacaaaagaagtaaaaatagccttaactgat2100 gacattccaccattgtgatttgttcctgccccaccctaactgatcaatgtactttgtaat2160 ctcccccacccttaagaaggtactttgtaatcttccccacccttaagaaggttctttgta2220 attctccccacccttgagaatgtactttgtgagatccaccctgcccacaaaacattgctc2280 ttaacttcaccgcctaacccaaaacctataagaactaatgataatccatcacccttcgct2340 gactctcttttcggactcagcccacctgcacccaggtgaaataaacagctttattgctca2400 ~aaaaa 2406 <210>

<211>

<212>
DNA

<213>
Human <400>

tgtttttcacacactggatgtttattattagaaaatagcttctatcagctgtcagtacca60 aacaagttgaaaggagcgagcttctcaccatatttttttttctccttaatgatatttaaa120 taaacagctcactgtgtgagctcacgccctttttccctttaaaaactgaataattaaatg180 aagtttagtacaaaacattcttcaaatatgacttgttctgcatctgttatgctgtctcct240 tgagtaatggacgcgaaagagatgaaaaagaccactcaggctaccaaagtaccccaaaga300 atccatacgagaaactgagaaacaaactaactcaaataagacccaaccaaaccaagaaac360 cagtttttacgttgactttttgattttgattatcatctaagtttaatatatatatatatg420 tgtgtgtgtttgaaatagtaataaaaaaggaagaattgaattgcatccgtagcaggacaa480 ccttcctcat acgttaaaga ggtgttcaga aaattccata cagtatctgc 530 <210> 29 <211> 1785 <212> DNA
<213> Human <400>

gggggaattatgttgatgactattctctctattctctctctctctctttttttttttttg 60 gagatagagtcttgctctgtcacccaggctggatcttggctcgctgcagcctctgcctcc 120 tgggttcaagcgattctcctgccttggcctctcgagtggctgggattgcaggcacctgcc 180 accgcgcccggctagtttttgtatttttggcagagatggggtttcgccgtgttggccagg 240 atggtctcgatctcttgacctcatggtctgcctgccttggcctcccaaagtgccggaatt 300 acaggcatgagccaccacacctggccactgttctcaaattgtattatggagttttttttt 360 ttttacaaaatatggatatattttaatttactcaaatgggaactactgataagcagttct 420 tatttttccagcataagcaaggctacaataaatatctttgaatatatgtactgatgcttt 480 ttgttttttgttgaagctatatcccaataagtgataagtacggtctaagagagaacatgt 540 tttttacaattttgattgatatcatattgggccacgcatggtggctcaggcctggcatcc 600 cggcactttgggaggttgaggtgggaggatagcttgagctcaggagttcaagaccagctt 660 gagcaacctggtgagacctcatctctactaaaaaaacaaaacaaacaaacacaaaattag 720 ctaggtgtggtggcatgtgccagtagtcccagctagttgggaggctgaggtggaaagatt 780 gcttgatcctgggaggttgaggctacagtgagctgtgatggtatcactgcactctatcct 840 ggacaacacagcaagaacctgcctcaaacaaatgtatttggttgatattgtatcagattt 900 cttctgaaaaacgttttaatggtttagactttcaccaagtgcaagaaactggcattttct 960 ttgtaactggcctggaatgttaccactcttttaaacttttgtcaagatgatcgtgagaaa 1020 tagtatctaattacttcaatttgcatttccctgactcctaatgaagttcagcatctcttc 1080 aaatctttattgggcatttggattttctcttcagtgaattgcttcatcatattctccatt 1140 tattctaaagttgtgttcctatttgtcgctttcaaatctagtttggtggaatccttgcat 1200 gttagaaaccttaaccctcgtaatatgtgttgtagatatttttccctcgcctatgagttg 1260 tctttcatccttgagcatgagttttagagtcagaagaacaacagtaggatttgaatcatg 1320 ttacgttattttctagttgtcgtattttttatttcttcagcctcttagaatcttagtttc 1380 ctttaaaatt gagataatag tatctacttt attcaaaaaa attttttggc tggacgcggt 1440 ggctcacgct tgtgatccca ccattttggg aggccaaggc aggcggatca cctgaggtca 1500 ggagtttgag accagcttgg ccaacgtggt gaaaacccat ctctactaaa aatacaaaaa 1560 ttagccaggt acagcggggc atgcctgtag tcccaggtac tcgggaggct gaggcaggag 1620 aatcacttga acccgggagg cagagatgag gtagtgagct gagatcgcac cactgcactc 1680 cggcctgagt ggtagggcga gactctgtct caaaaaaaaa attgtttttt catttatttg 1740 tttgttgaga ctccacttca aaaaataaaa aaaaaaaaaa aaaaa 1785 <210> 30 <211> 2653 <212> DNA
<213> Human <400>

gaagttacaagagtagtagatgaacaactaaaggcgttgcttgagtccatggttgatgct 60 gctgagaatctttgtcccaatgtgatgaaaaaagcccacattcgacaagacttgattcat 120 gccagcaccgaaaagatttctattccacgtacctttgttaaaaatgtcctgttggagcag 180 tctggaattgatatccttaacaaaattagtgaagtaaaattgacagtggcctcgttcctg 240 tctgatagaattgtggatgaaatcctggatgcactctcacattgccatcataaactggct 300 gaccatttcagcagacgtggcaagacccttcctcaacaagaatccttagagatcgagctg 360 gctgaggagaggccagttaaacgttccatcatcacagtggaggagctaacagagatagag 420 cgtttggaagatctggatacctgtatgatgacccctaaatccaaaaggaagagtatccat 480 agccgaatgctgcggcctgtttctagggcttttgaaatggagtttgatctagataaagcg 540 ctggaagaggtaccaattcacatcgaagacccgcccttcccatccctcagacaggagaag 600 cggagctcgggatttatctctgagttgccctctgaagaggggaagaagctggaacacttt 660 accaagttaaggccaaaaaggaataagaagcagcaacccacccaagcagcggtctgtgct720 gccaacatagtctcacaagatggtgaacagaatggtctcatggggagagtggatgaaggt780 gtagatgaattttttaccaagaaggtgaccaaaatggattccaagaaatggtcaacaaga840 ggctcagagtcccatgagcttaatgaaggaggagatgaaaagaaaaagcgagattctcgg900 aaaagtagtggctttctcaatttaatcaaatcccggtccaaatccgagcgaccaccaacg960 atcttgatgacagaagaaccctcctcaccaaaaggggcagtcagaagtccacctgtggac1020 tgtcccaggaaggacacaaaggccgccgagcacaatggcaattctgaacggatagaggag1080 ataaaaacacctgactcctttgaagagagtcaaggggaagaaatagggaaggtggaacgg1140 agtgacagca agagcagccc acaggcaggg cggaggtatg gggtccaggt gatgggcagt 1200 ggtctgctgg cagagatgaa agccaagcaa gagaaccgct ttggtttggg aacaccagaa 1260 aagaatacca aagcagaacc caaagcggaa gcaggctcca ggtctcggag ctcatccagc 1320 acacctacgagcccgaagcccctcctgcagtcccccaaacccagtctggcagcacggccc1380 gtcatcccgcagaaaccaagaaccgcctcacggcctgatgacattccagactctccatct1440 agcccgaaagttgcccttcttccacctgtcctgaaaaaagttccttcagacaaagagaga1500 gatggccagagtagcccccagcccagccccaggacattttcacaggaagtttcaaggaga1560 agctggggccagcaggcccaggagtatcaagaacaaaagcaacggtcctccagtaaagat1620 ggccatcaaggcagcaaatctaatgactccggggaagaagcagaaaaagagtttattttt1680 gtgtaaaggtcacccacgcagaagtcttcctgtgcagggtgctttggtagccatcagaga1740 ggaaccaagggcaacatcttttcttcccaggcgttcttctctgggtgctttattctcttc1800 tttttctttatttcgcccccacccccatcccctgccttttttttttttttttttttgtat1860 agaaacagatccatttcttggtaatcaaag.cacatttgtttggtcttcctccaacccttt1920 gcatttgatttctaaacattccttcatatgcctttaatgaaagccagcaattatcccatg1980 ggccctacttgaatttatctgaggcagctacagattgccctgcaagatgagtttttggag2040 ataaatgaaataactggacacacactcacacaagtaacaccacagcagacctcggagtac2100 tgctaagtgtacctgtgtcaaatccgcacaggactcaatatagcaatttattcttgatgt2160 atgcaattgcacattgtaattatattaacagagcacactaataatttgtatagattatat2220 atattagatcttgggtatggtttttaccttctcccatggggaacttcttccttcctgatg2280 tggaattgtacatttaaagcttggtcggtgacctttgcataccatcaacgagcacagcta2340 agaacagagtgagagaggcccatggctgattttaccatgtgcccagattaatgtatatag2400 ttgattggaatgaggttttatgaatattcatgtttttgaaggcctttaatttctgtctgc2460 atattagcttttaatgtgtgattttaagagagaatactttgacacctgtaaaaatcaaaa2520 tactactctttataagacatttcacaaatattcacttacattacaggctggaagtatttt2580 attcatatgtatatttataccaataaaatgattttacaagtggaaaaaaaaaaaaaaaaa2640 aaaaaaaaaaaaa 2653 <210> 31 <211> 1379 <212> DNA
<2l3> Human <400> 31 tgcaagatgc ccctgaagct gcgggggaag aagaaggcca agtccaagga gaccgccggg 60 ctggtggagg gcgagccgac gggcgcgggc ggcgggagcc tctcagcgtc ccgggctccc 120 gcacgcaggc tggtcttcca cgcgcagctg gcgcacggta gtgccacggg ccgagtggag 180 ggcttctcca gcatccagga gctctacgcc cagatcgcgg gcgcgtttga aatctcgccg 240 tcggagatct tatattgcac tttaaacaca cctaaaattg acatggaaag actcttagga 300 ggacaactaggactagaagatttcatatttgcccatgtgaaaggaatcgaaaaagaagtg360 aatgtgtataaatctgaggattcacttggtctcaccattacagataatggtgttggctat420 gcttttataaagagaattaaagatggtggtgttattgactcagttaaaacaatctgtgtt480 ggggatcatattgaatccataaatggagaaaatattgttgggtggcgtcactatgatgtt540 gctaagaagttaaaggaattaaaaaaggaggaactctttactatgaagttaatagaacct600 aagaaggcatttgaaatagagctgaggtcaaaggctggaaagtcatcaggagaaaaaatt660 ggttgtggaagggcaacacttcgcctgagatcaaaaggtcctgccaccgtggaagaaatg720 ccttctgaaaccaaagcaaaggcaattgaaaagattgatgatgttcttgagttgtacatg780 ggaattcgagatattgatttagccaccacaatgtttgaagctggaaaggacaaagtaaat840 ccagatgaatttgctgtggcacttgacgaaactcttggagactttgcgttcccagacgaa900 tttgtctttgatgtttggggagtcattggtgatgccaaacgaagaggattatgatgtgta960 cactccatctctgaagaaacaacccatcgttcttttttttctcttttttaaaaagtccta1020 taagatctgtttttggacacctttactaactctggtttaatttcatgtgtatggaatata1080 ttctttgaaatataattttggtaattttgatttctgggcactttttaacattgctgatgt1140 agtatgcttaagagaaatgacctaaataaggatcaattgtaatattcattcaaaaggttt1200 ttaaaagtaagttttaaggagtatttctcgacagatgattttcttctccattaataccca1260 tgctttgtttttcacatataaatagatgatttcaatagctttgtagttttttttcaaaat1320 cttaatgtaaactaggattggagtatgatttacctcatagtatcttcactgtgttatcc 1379 <210> 32 <211> 585 <212> DNA
<213> Human <400> 32 tttttttttt ttttaaaaaa gagcatttta ttttaataaa gaataaaaga gatcaatata 60 ctgttttaat ggatacaaaa ataaatattc attcagcata ttaaagatat gtgctttgac 120 attcatttga attggagatt caagcctatt gttatcttat gaacacttca gcaaacagga 180 ctgccattct taaaaatata atgctttgtt ggacaaaagg gacaagccac gtcccctggt 240 cctctcctct attcgcctgt gaactccatc cacacgtaaa ggacctctgg gtctgactgt 300 cccctccaca ggcatggtgc tgggaaaagg aaacaggcat atctggcttt tcagatttta 360 aaccggaaac tctcacagtc acaaatccac catgagactt gggagattgg atgagctgtc 420 tcccaaaccc taacaccttc caccttctca aaatgaaggc tgccctttca ctgggaggtt 480 ctgaatgcgg gatggtgctg actcaggctg ggcacaaagg agaaaggagg acatggaaaa 540 tccgacaatt caaagtacaa atatttcaaa cacatgtgaa aacca 585 <210> 33 <211> 1964 <212> DNA
<213> Human <400>

tgatgacaacaatggaagcagtggagtccccggagtccctggccgccgttgcttacctgc60 tgaaccttgtcctgaagcgtgttcccagccctgtgcttattaagaagttctctgatacct120 ccaaagccttcatggatatcatgtcagctcaggccagcagcggctccacctctgtcctcc180 gatgggtcctttcctgcctggccacccttctgcggaagcaagacctggaggcctggggct240 accccgtgacccttcaggtgtaccatgggctgctgagcttcacggtgcatcccaagccca300 agatccggaaggctgcccagcatggagtatgctcagtcctcaagggcagtgaattcatgt360 ttgaaaaggcccctgcccatcatcctgctgccatttccactgccaagttctgcatccagg420 agattgagaagtctggaggctccaaggaggccaccaccacgctgcacatgctgacgctgc480 tgaaggacctgctgccctgcttcccggaaggcctggtgaagagctgcagtgagactctcc540 tcagggtcatgaccttgagccatgtgctggtgacagcctgtgccatgcaggcctttcaca600 gcctcttccacgccaggcctggcctgagcaccctgtcagcagagctcaacgcccagatca660 tcacggccctgtacgactatgttcccagtgagaatgatttacaacccctgctagcctggc720 ttaaggtcatggagaaagcccacatcaacctggtgaggttgcagtgggacctggggctag780 gccacctccctcgcttttttggaactgcggtgacctgcctcctttccccacacttgcaag840 tgctgactgctgctacgcagagcctcaaggagatcctgaaggaatgcgtggctccccaca900 tggctgacattggctccgtgacctcctcggcctcaggccctgcccaatctgttgccaaga960 tgttcagggcagtggaggagggcctgacgtacaaattccatgcggcctggagctccgtgt1020 tgcagctgctgtgtgtcttcttcgaggcgtgtgggagacaggccgaccctgtgatgagga1080 agtgcctccagtccctgtgtgacctgcgcctctcccctcatttcccccacacggcggctc1140 ttgaccaggcagtgggggctgcggtgaccagtatgggacctgaggtggtgctgcaggctg1200 tgcctttggaaattgatggctctgaggagactctggatttcccacggagctggctgctgc1260 ctgtcatccgagaccatgttcaggaaacgcgacttggtttttttcaccacctacttcttg1320 cccctggctaacaccctgaagagcaaagccatggacctggctcaggcaggcagcacagtg1380 gaatctaagatctacgacacactccagtggcagatgtggacactcctgcctgggttctgc1440 acaaggcctacagatgtggccatctccttcaaagggctggcacggacgctgggcatggcc1500 atcagcgagcgtccagacctgagggtcaccgtgtgccaggccctgcgcaccctcatcacc1560 aagggctgccaggcagaggctgaccgtgctgaagtgagtcgctttgccaagaactttctg1620 ccgatcctcttcaacctgtatgggcagcccgtggcagccggggacactccagcccctcgc1680 cgggctgtgctggaaaccatcagaacttacctcaccatcactgacactcagttggtgaac1740 agtctcctggaaaaagccagtgagaaggtgctcgaccctgccagctctgactttaccaga1800 ttgtctgtcctggacctggtcgtggccttggctccgtgtgctgacgaagctgccatcagt1860 aagctatactccaccatccggccctacctagattgctaacaaatcagaaatatgacaatt1920 aatgattaaagactgtgattgccaccaaaaaaaaaaaaaaaaaa 1964 <210> 34 <211> 2599 <212> DNA
<213> Human <400>

aaatccgagcctcgcgtgggctcctggcccccgacggacaccaccaggcccacggagccc 60 accatgccgcgcccggcccccgcgcgccgcctcccgggactcctcctgctgctctggccg 120 ctgctgctgctgccctccgccgcccccgaccccgtggcccgcccgggcttccggaggctg 180 gagacccgaggtcccgggggcagccctggacgccgcccctctcctgcggctcccgacggc 240 gcgcccgcttccgggaccagcgagcctggccgcgcccgcggtgcaggtgtttgcaagagc 300 agacccttggacctggtgtttatcattgatagttctcgtagcgtacggcccctggaattc 360 accaaagtgaaaacttttgtctcccggataatcgacactctggacattgggccagccgac 420 acgcgggtggcagtggtgaactatgctagcactgtgaagatcgagttccaactccaggcc 480 tacacagataagcagtccctgaagcaggctgtgggtcgaatcacacccttgtcaacaggc 540 accatgtcaggcctagccatccagacagcaatggacgaagccttcacagtggaggcaggg 600 gctcgagagccctcttctaacatccctaaggtggccatcattgttacagatgggaggccc 660 caggaccaggtgaatgaagtggcggctcgggcccaagcatctggtat,tgagctctatgct 720 gtgggcgtggaccgggcagacatggcgtccctcaagatgatggccagtgagcccctagag 780 gagcatgttttctacgtggagacctatggggtcattgagaaactttcctctagattccag 840 gaaaccttctgtgcgctggacccctgtgtgcttggaacacaccagtgccagcacgtctgc-900 atcagtgatggggaaggcaagcaccactgtgagtgtagccaaggatacaccttgaatgcc960 gacaagaaaacgtgttcagctcttgataggtgtgctcttaacacccacggatgtgagcac1020 atctgtgtgaatgacagaagtggctcttatcattgtgagtgctatgaaggttataccttg1080 aatgaagacaggaaaacttgttcagctcaagataaatgtgctttgggtacccatgggtgt1140 cagcacatttgtgtgaatgacagaacagggtcccatcattgtgaatgctatgagggctac1200 actctgaatgcagataaaaaaacatgttcagtccgtgacaagtgtgccctaggctctcat1260 ggttgccagcacatttgtgtgagtgatggggccgcatcctaccactgtgattgctatcct1320 ggctacaccttaaatgaggacaagaaaacatgttcagccactgaggaagcacgaagactt1380 gtttccactgaagatgcttgtggatgtgaagctacactggcattccaggacaaggtcagc1440 tcgtatcttcaaagactgaacactaaacttgatgacattttggagaagttgaaaataaat1500 gaatatggacaaatacatcgttaaattgctccaatttctcacctgaaaatgtggacagct1560 tggtgtacttaatactcatgcattcttttgcacacctgttattgccaatgttcctgctaa1620 taatttgccattatctgtattaatgcttgaatattactggataaattgtatgaagatctt1680 ctgcagaatcagcatgatttttccaaggaaatacatatgcagatacttattaagagcaaa1740 ctttagtgtctctaagttatgactgtgaaatgattggtaggaaatagaatgaaaagttta1800 gtgtttctttatctactaattgagccatttaatttttaaatgtttatattagataaccat1860 attcacaatggaaactttaggtctagtttcttttgatagtatttataatataaatcaatc1920 ttattactgagagtgcaaattgtacaaggtatttacacatacaacttcatataactgaga1980 tgaatgtaattttgaactgtttaacactttttgttttttgcttattttgttggagtatta2040 ttgaagatgtgatcaatagattgtaatacacatatctaaaaatagttaacacagatcaag2100 tgaacattacattgccatttttaattcattctggtctttgaaagaaatgtactactaaag2160 agcactagttgtgaatttagggtgttaaactttttaccaagtacaaaaatcccaaattca2220 ctttattattttgcttcaggatccaagtgacaaagttatatatttataaaattgctataa2280 atcgacaaaatctaatgttgtctttttaatgttagtgatccacctgcctcagcctcccaa2340 agtgctgggattacaggcttgaaagtctaacttttttttacttatatatttgatacatat2400 aattcttttggctttgaaacttgcaactttgagaacaaaacagtcctttaaattttgcac2460 tgctcaattctgtttttcgtttgcattgtctttaatataataaaagttattacctttaca2520 tattatcatgtctatttttgatgactcatcaattttgtctattaaagatatttctttaaa2580 ttaaaaaaaa aaaaaaaaa 2599 <210> 35 <211> 3060 <212> DNA
<213> Human <400>

tccggaaggaggcgaaccctgaggcgggcccggcaagccttccctgcggccggcagagcc 60 caacgactagtgggactccgcgggggcgggggtagctggagcctggctctggcctggcag 120 gagccgagcttgttccggaagaagccgagcggacgggggccagcctcagcgtcccgggag 180 tgaggcgatagctgcggcggcgacagcgcgggccgggatgaaccgcgacggctgaggcag 240 cggaggtgccggctgcgcgggccccagtgagactccctcgaagcggcagcccaccgttcg 300 gggctttgcctcgagccgagccctgcccccgcgagcctcccggacccctttgtgcggccg 360 gaggcggcggcgggaacggccatggcggccaacatgtaccgggtgggagattacgtctat 420 tttgagaactcttccagcaatccttacctggttagacggattgaggagctcaacaagact 480;

gcaaatggaaatgtggaggcaaaggttgtctgtcttttccggcgcagggacatttctagt 540 agcctcaacagcctggctgatagtaatgccagggagtttgaagaggaatcaaagcagcca 600 ggggtgtctgagcagcagcgccatcaactgaagcaccgggaactttttctttctcggcaa 660 tttgaatcattaccagccacccacatacgggggaaatgcagtgtgaccctcttgaatgag 720 acagatatcttgagccagtacctggaaaaggaggactgctttttttactcactggtgttt 780 gaccccgtgcagaagacacttctcgctgatcagggcgagattagagttggttgcaaatac 840 caagctgagatcccagatcgcctagtagagggagaatctgataatcggaaccagcagaag 900 atggagatgaaggtctgggacccagacaaccctctcacagaccggcagatcgaccagttt 960 cttgtggtggcccgagctgtgggaacctttgcaagagccctagattgtagcagctccatt 1020 cggcagccaagcttgcacatgagtgcagctgctgcctcccgagatatcactctgtttcac 1080 gccatggataccttgcaaaggaacggctacgacctggctaaggccatgtcgaccctggta 1140 ccccagggaggcccggtgctgtgtcgggatgagatggaggaatggtcagcctcagaggcc,1200 atgctatttgaggaggccctagagaagtatgggaaggacttcaatgatattcgccaggat 1260 tttctaccctggaagtcacttgccagcatagtccagttttattacatgtggaaaaccaca 1320 gaccggtatattcagcagaaaaggttgaaagctgctgaagcagacagcaaactgaaacag 1380 gtctacattcccacctacactaagccaaaccctaaccagatcatttctgtgggttcaaaa 1440 cctggcatgaatggggctggatttcagaagggcctgacttgtgagagttgccacaccaca 1500 cagtctgctcagtggtatgcctggggcccacctaacatgcagtgccgcctctgtgcttcc 1560 tgttggatctactggaagaagtatgggggactgaagaccccaactcagcttgagggggcc 1620 actcggggca ccacggagcc acactcaagg ggtcatttat ccagacctga agctcaaagt 1680 ctctctcctt acacaaccag cgccaacagg gccaagctac tggctaagaa cagacaaact 1740 ttcctgcttc agaccacaaa gctgacccgt cttgccagac gcatgtgcag ggacctatta 1800 cagccaagga gggccgcccg acggccttat gctcctatca atgccaatgc catcaaagca 1860 gagtgctcca ttcgacttcc taaggccgcc aagactccat tgaagattca ccctctggtg 1920 cggctgcccc tggcaactat cgtcaaagat ctggtggccc aggcacccct gaaaccaaaa 1980 acacctcggg gtaccaagac accgatcaac agaaaccagc tgtcccagaa ccggggactg 2040 gggggcatta tggtgaaacg ggcctatgag actatggcag gggcaggggt tcctttctct 2100 gccaatggaa ggcctctggc ttcagggatt cgttcaagct cacagccagc agccaagcgt 2160 cagaaactaa acccagctga tgcccccaat cctgtggtgt ttgtggccac aaaggatacc 2220 agggccctac ggaaggctct gacccatctg gaaatgcggc gagctgctcg ccgacccaac 2280 ttgcccctga aggtgaagcc aacgctgatt gcagtgcggc cccctgtccc tctacctgca 2340 ccctcacatc ctgccagcac caatgagcct attgtcctgg aggactgagc acctgtgggg 2400 aagggaggtg ggctgagagg tagagggtgg atgcccaggg cacccaaacc tcccttccct 2460 ttcgtgtcga agggagtgag gagtgaatta aggaagagag caagtgagtg tgtgtccctg 2520 gaggggttgg gcgccctctg gtgttaccac ctcgagactt gtctcatgcc tccatgcttg 2580 ccgatggagg acagactgca ggaacttggc ccatgtggga acctagcctg ttttgggggg 2640 taggacccac agatgtcttg gacagttttg gggggagggt tttttaattt tttaaaagtt 2700 ttgcctccct ttgtgaaagg ggatggggag gggaagagta aacagataac aggtggtggt 2760 acctggttgg gggagggggg cgtgcactgc catgtctttt tttttttttt tttttttttt 2820 tttcctaatt gggggtttct ctttctgtcc ggtgtccgga ctttcctaat tggagtttga 2880 ggcccctaag ctggcatcaa ccccaggcca cgctcgctct ttccttccct cccctccccc 2940 tctgcctttt gtacgccagt tctcagaaat aaagatcttt tgtccgtttt tttaacctcg 3000 gattctgtaa ttggttctta tagtaacaaa taaaaagctg ttttcttcag cttctcctgg 3060 <210> 36 <211> 15720 <212> DNA
<213> Human <400> 36 caacccacac cgcccctgcc agccaccatg gggctgccac tagcccgcct ggcggctgtg 60 tgcctggccc tgtctttggc agggggctcg gagctccaga cagagggcag aacccgatac 120 cacggccgcaacgtctgcagcacctggggcaacttccactacaagaccttcgacggggac 180 gtcttccgcttccccggcctctgcgactacaacttcgcctccgactgccgaggctcctac 240 aaggaatttgctgtgcacctgaagcggggtccgggccaggctgaggcccccgccggggtg 300 gagtccatcctgctgaccatcaaggatgacaccatctacctcacccgccacctggctgtg 360 cttaacggggccgtggtcagcaccccgcactacagccccgggctgctcattgagaagagc 420 gatgcctacaccaaagtctactcccgcgccggcctcaccctcatgtggaaccgggaggat 480 gcactcatgctggagctggacactaagttccggaaccacacctgtggcctctgcggggac 540 tacaacggcctgcagagctattcagaattcctctctgacggcgtgctcttcagtcccctg 600 gagtttgggaacatgcagaagatcaaccagcccgatgtggtgtgtgaggatcccgaggag 660 gaggtggcccccgcatcctgctccgagcaccgcgccgagtgtgagaggctgctgaccgcc 720 gaggccttcgcggactgtcaggacctggtgccgctggagccgtatctgcgcgcctgccag 780 caggaccgctgccggtgcccgggcggtgacacctgcgtctgcagcaccgtggccgagttc 840 tcccgccagtgctcccacgccggcggccggcccgggaactggaggaccgccacgctctgc900 cccaagacctgccccgggaacctggtgtacctggagagcggctcgccctgcatggacacc960 tgctcacacctggaggtgagcagcctgtgcgaggagcaccgcatggacggctgtttctgc1020 ccagaaggcaccgtatatgacgacatcggggacagtggctgcgttcctgtgagccagtgc1080 cactgcaggctgcacggacacctgtacacaccgggccaggagatcaccaatgactgcgag1140 cagtgtgtctgtaacgctggccgctgggtgtgcaaagacctgccctgccccggcacctgt1200 gccctggaaggcggctcccacatcaccaccttcgatgggaagacgtacaccttccacggg1260 gactgctactatgtcctggccaagggtgaccacaacgattcctacgctctcctgggcgag1320 ctggccccctgtggctccacagacaagcagacctgcctgaagacggtggtgctgctggct1380 gacaagaagaagaatgcggtggtcttcaagtccgatggcagtgtactgctcaaccagctg1440 caggtgaacctgccccacgtgaccgcgagcttctctgtcttccgcccgtcttcctaccac1500 atcatggtgagcatggccattggcgtccggctgcaggtgcagctggccccagtcatgcaa1560 ctctttgtgacactggaccaggcctcccaggggcaggtgcagggcctctgcgggaacttc1620 aacggcctggaaggtgacgacttcaagacggccagcgggctggtggaggccacgggggcc1680 ggctttgccaacacctggaaggcacagtcaacctgccatgacaagctggactggttggac1740 gatccctgctccctgaacatcgagagcgccaactacgccgagcactggtgctccctcctg1800 aagaagacagagaccccctttggcaggtgccactcggctgtggaccctgctgagtattac1860 aagaggtgca aatatgacac gtgtaactgt cagaacaatg aggactgcct gtgcgccgcc 1920 ctgtcctcctacgcgcgcgcctgcaccgccaagggcgtcatgctgtggggctggcgggag1980 catgtctgcaacaaggatgtgggctcctgccccaactcgcaggtcttcctgtacaacctg2040 accacctgccagcagacctgccgctccctctccgaggccgacagccactgtctcgagggc2100 tttgcgcctgtggacggctgcggctgccctgaccacaccttcctggacgagaagggccgc2160 tgcgtacccctggccaagtgctcctgttaccaccgcggtctctacctggaggcgggggat2220 gtggtcgtcaggcaggaagaacgatgtgtgtgccgggatgggcggctgcactgtaggcag2280 atccggctgatcggccagagctgcacggccccaaagatccacatggactgcagcaacctg2340 actgcactggccacctcgaagccccgagccctcagctgccagacgctggccgccggctat2400 taccacacagagtgtgtcagtggctgtgtgtgccccgacgggctgatggatgacggccgg2460 ggtggctgcgtggtggagaaggaatgcccttgcgtccataacaacgacctgtattcttcc2520 ggcgccaagatcaaggtggactgcaatacctgcacctgcaagagaggacgctgggtgtgc2580 acccaggctgtgtgccatggcacctgctccatttacgggagtggccactacatcaccttt2640 gatgggaagtactacgactttgacggacactgctcctacgtggctgttcaggactactgc2700 ggccagaactcctcactgggctcattcagcatcatcaccgagaacgtcccctgtggcact2760 acgggcgtcacctgctccaaggccatcaagatcttcatggggaggacggagctgaagttg2820 gaagacaagcaccgtgtggtgatccagcgtgatgagggtcaccacgtggcctacaccacg2880 cgggaggtgggccagtacctggtggtggagtccagcacgggcatcatcgtcatctgggac2940 aagaggaccaccgtgttcatcaagctggctccctcctacaagggcaccgtgtgtggcctg3000 tgtgggaactttgaccaccgctccaacaacgacttcaccacgcgggaccacatggtggtg3060 agcagcgagctggacttcgggaacagctggaaggaggcccccacctgcccagatgtgagc3120 accaaccccgagccctgcagcctgaacccgcaccgccgctcctgggccgagaagcagtgc3180 agcatcctcaaaagcagcgtgttcagcatctgccacagcaaggtggaccccaagcccttc3240 tacgaggcctgtgtgcacgactcgtgctcctgtgacacgggtggggactgtgagtgcttc3300 tgctctgccgtggcctcctacgcccaggagtgtaccaaagagggggcctgcgtgttctgg3360 aggacgccggacctgtgccccatattctgcgactactacaaccctccgcatgagtgtgag3420 tggcactatgagccatgtgggaaccggagcttcgagacctgcaggaccatcaacggcatc3480 cactccaacatctccgtgtcctacctggagggctgctacccccggtgccccaaggacagg3540 cccatctatgaggaggatctgaagaagtgtgtcactgcagacaagtgtggctgctatgtc3600 gaggacacccactacccacctggagcatcggttcccaccgaggagacctgcaagtcctgc3660 gtgtgtacca actcctccca agtcgtctgc aggccggagg aaggaaagat tcttaaccag 3720 acccaggatg gcgccttctg ctactgggag atctgtggcc ccaacgggac ggtggagaag 3780 cacttcaaca tctgttccat tacgacacgc ccgtccaccc tgaccacctt caccaccatc 3840 accctcccca ccacccccac ctccttcacc actaccacca ccaccaccac cccgacctcc 3900 agcacagttt tatcaacaac tccgaagctg tgctgcctct ggtctgactg gatcaatgag 3960 gaccacccca gcagtggcag cgacgacggt gaccgagaac catttgatgg ggtctgcggg 4020 gcccctgagg acatcgagtg caggtcggtc aaggatcccc acctcagctt ggagcagcat 4080 ggccagaagg tgcagtgtga tgtctctgtt gggttcattt gcaagaatga agaccagttt 4140 ggaaatggac catttggact gtgttacgac tacaagatac gtgtcaattg ttgctggccc 4200 atggataagt gtatcaccac tcccagccct ccaactacca ctcccagccc tccaccaacc 4260 acgacgacca cccttccacc aaccaccacc cccagccctc caaccaccac cacaaccacc 4320 cctccaccaa ccaccacccc cagccctcca ataaccacca cgaccacccc tctaccaacc 4380 acc~actccca gccctccaat aagcaccaca accacccctc caccaaccac cactcccagc 4440 cctccaacca ccactcccag ccctccaacc accactccca gccctccaac aaccaccaca 4500 accacccctc caccaaccac cactcccagc cctccaatga ctacgcccat cactccacca 4560 gccagcacta ccacccttcc accaaccacc actcccagcc ctccaacaac caccacaacc 4620 acccctccac caaccaccac tcccagtcct ccaacgacta cgcccatcac tccaccaacc 4680 agcactacta cccttccacc aaccaccact cccagccctc caccaaccac cacaaccacc 4740 cctccaccaa ccaccactcc cagccctcca acaaccacca ctcccagtcc tccaacaatc 4800 accacaacca cccctccacc aaccaccact cccagccctc caacaacgac cacaaccacc 4860 cctccaccaa ccaccactcc cagccctcca acgactacac ccatcactcc accaaccagc 4920 actaccaccc ttccaccaac caccactccc agccctccac caaccaccac aaccacccct 4980 ccaccaacca ccactcccag ccctccaaca accaccactc ccagccctcc aataaccacc 5040 acaaccaccc ctccaccaac caccactccc agctctccaa taaccaccac tcccagccct 5100 ccaacaacca ccatgaccac cccttcacca accaccaccc ccagctctcc aataaccacc 5160 acaaccaccc .cttcctcaac taccactccc agccctccac caaccaccat gaccacccct 5220 tcaccaacca ccactcccag ccctccaaca accaccatga ccacccttcc accaaccacc 5280 acttccagcc ctctaacaac tactcctcta cctccatcaa taactcctcc tacattttca 5340 ccattctcaa cgacaacccc tactacccca tgcgtgcctc tctgcaattg gactggctgg 5400 ctggattctggaaaacccaactttcacaaaccaggtggagacacagaattgattggagac5460 gtctgtggaccaggctgggcagctaacatctcttgcagagccaccatgtatcctgatgtt5520 cccattggacagcttggacaaacagtggtgtgtgatgtctctgtggggctgatatgcaaa5580 aatgaagaccaaaagccaggtggggtcatccctatggccttctgcctcaactacgagatc5640 aacgttcagtgctgtgagtgtgtcacccaacccaccaccatgacaaccaccaccacagag5700 aacccaactccgccaaccacgacacccatcaccaccaccactacggtgaccccaacccca5760 acacccaccggcacacagaccccaaccacgacacccatcaccaccaccactacggtgacc5820 ccaaccccaacacccaccggcacacagaccccaaccacgacacccatcaccaccaccact5880 acggtgaccccaaccccaacacccaccggcacacagaccccaaccacgacacccatcacc5940 accaccactacggtgaccccaaccccaacacccaccggcacacagaccccaaccacgaca6000 cccatcaccaccaccactacggtgaccccaaccccaacacccaccggcacacagacccca6060 accacgacacccatcaccaccaccactacggtgaccccaaccccaacacccaccggcaca6120 cagaccccaaccacgacacccatcaccaccaccactacggtgaccccaaccccaacaccc6180 accggcacacagaccccaaccacgacacccatcaccaccaccactacggtgaccccaacc6240 ccaacacccaccggcacacagaccccaaccacgacacccatcaccaccaccactacggtg6300 accccaaccccaacacccaccggcacacagaccccaaccacgacacccatcaccaccacc6360 actacggtgaccccaaccccaacacccaccggcacacagaccccaaccacgacacccatc6420 accaccaccactacggtgaccccaaccccaacacccaccggcacacagaccccaaccacg6480 acacccatcaccaccaccactacggtgaccccaaccccaacacccaccggcacacagacc6540 ccaaccacgacacccatcaccaccaccactacggtgaccccaaccccaacacccaccggc6600 acacagaccccaaccacgacacccatcaccaccaccactacggtgaccccaaccccaaca6660 cccaccggcacacagaccccaaccacgacacccatcaccaccaccactacggtgacccca6720 accccaacacccaccggcacacagaccccaaccacgacacccatcaccaccaccactacg6780 gtgaccccaaccccaacacccaccggcacacagaccccaaccacgacacccatcaccacc6840 accactacggtgaccccaaccccaacacccaccggcacacagaccccaaccacgacaccc6900 atcaccaccaccactacggtgaccccaaccccaacacccaccggcacacagaccccaacc6960 acgacacccatcaccaccaccactacggtgaccccaaccccaacacccaccggcacacag7020 accccaaccacgacacccatcaccaccaccactacggtgaccccaaccccaacacccacc7080 ggcacacagaccccaaccacgacacccatcaccaccaccactacggtgaccccaacccca7140 acacccaccggcacacagaccccaaccacgacacccatcaccaccaccactacggtgacc7200 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 7260 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 7320 accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 7380 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 7440 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 7500 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 7560 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 7620 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 7680 accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc 7740 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 7800 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 7860 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 7920 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 7980 acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 8040 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 8100 accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg 8160 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 8220 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 8280 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 8340 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 8400 accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 8460 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 8520 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 8580 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 8040 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 8700 accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 8760 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 8820 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 8880 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 8940 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 9000 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 9060 accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc 9120 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 9180 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 9240 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 9300 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 9360 acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 9420 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 9480 accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg 9540 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 9600 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 9660 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 9720 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 9780 accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 9840 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 9900 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 9960 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 10020 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 10080 accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 10140 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 10200 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 10260 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 10320 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 10380 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 10440 accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc 10500 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 10560 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 10620 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 10680 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 10740 acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 10800 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 10860 accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg 10920 gtgaccccaa ccccaacacc caccggcaca cagaccccaa ccacgacacc catcaccacc 10980 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 11040 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 11100 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 11160 accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 11220 ggcacacaga ccccaaccac gacacccatc accaccacca ctacggtgac cccaacccca 11280 acacccaccg gcacacagac cccaaccacg acacccatca ccaccaccac tacggtgacc 11340 ccaaccccaa cacccaccgg cacacagacc ccaaccacga cacccatcac caccaccact 11400 acggtgaccc caaccccaac acccaccggc acacagaccc caaccacgac acccatcacc 11460 accaccacta cggtgacccc aaccccaaca cccaccggca cacagacccc aaccacgaca 11520 cccatcacca ccaccactac ggtgacccca accccaacac ccaccggcac acagacccca 11580 accacgacac ccatcaccac caccactacg gtgaccccaa ccccaacacc caccggcaca 11640 cagaccccaa ccacgacacc catcaccacc accactacgg tgaccccaac cccaacaccc 11700 accggcacac agaccccaac cacgacaccc atcaccacca ccactacggt gaccccaacc 11760 ccaacaccca ccggcacaca gaccccaacc acgacaccca tcaccaccac cactacggtg 11820 accccaaccc caacacccac cggcacacag accccaacca cgacacccat caccaccacc 11880 actacggtga ccccaacccc aacacccacc ggcacacaga ccccaaccac gacacccatc 11940 accaccacca ctacggtgac cccaacccca acacccaccg gcacacagac cccaaccacg 12000 acacccatca ccaccaccac tacggtgacc ccaaccccaa cacccaccgg cacacagacc 12060 ccaaccacga cacccatcac caccaccact acggtgaccc caaccccaac acccaccggc 12120 acacagaccc caaccacgac acccatcacc accaccacta cggtgacccc aaccccaaca 12180 cccaccggca cacagacccc aaccacgaca cccatcacca ccaccactac ggtgacccca 12240 accccaacac ccaccggcac acagacccca accacgacac ccatcaccac caccactacg 12300 gtgaccccaa ccccaacacc.caccggcaca cagaccccaa ccacgacacc catcaccacc 12360 accactacgg tgaccccaac cccaacaccc accggcacac agaccccaac cacgacaccc 12420 atcaccacca ccactacggt gaccccaacc ccaacaccca ccggcacaca gaccccaacc 12480 acgacaccca tcaccaccac cactacggtg accccaaccc caacacccac cggcacacag 12540 accccaacca cgacacccat caccaccacc actacggtga ccccaacccc aacacccacc 12600 ggcacacaga ccgggccccc cacccacaca agcacagcac cgattgctga gttgaccaca 12660 tCCaatCCtC CgCCtgagtC CtCaaCCCCt CagaCCtCtC ggtccacctc ttCCCCtCtC 12720 acggagtcaa ccacccttct gagtacccta ccacctgcca ttgagatgac cagcacggcc 12780 ccaccctcca cacccacggc acccacgacc acgagcggag gccacacact gtctccaccg 12840 cccagcacca ccacgtcccc tccaggcacc cccactcgcg gtaccacgac cgggtcatct 12900 tcagccccca cccccagcac tgtgcagacg accaccacca gtgcctggac cccaacgccg 12960 accccactct ccacacccag catcatcagg accacaggcc tgaggcccta cccttcctct 13020 gtgcttatct gctgtgtcct gaacgacacc tactacgcac caggtgagga ggtgtacaac 13080 ggcacatacg gagacacctg ttatttcgtc aactgctcac tgagctgtac gttggagttc 13140 tataactggt cctgcccatc cacgccctcc ccaacaccca cgccctccaa gtcgacgccc 13200 acgccttcca agccatcgtc cacgccctcc aagccgacgc ccggcaccaa gccccccgag 13260 tgcccagact ttgatcctcc cagacaggag aacgagactt ggtggctgtg cgactgcttc 13320 atggccacgt gcaagtacaa caacacggtg gagatcgtga aggtggagtg tgagccgccg 13380 cccatgccca cctgctccaa cggcctccaa cccgtgcgcg tcgaggaccc cgacggctgc 13440 tgctggcact gggagtgcga ctgctactgc acgggctggg gcgacccgca ctatgtcacc 13500 ttcgacggac tctactacag ctaccagggc aactgcacct acgtgctggt ggaggagatc 13560 agcccctccg tggacaactt cggagtttac atcgacaact accactgcga tcccaacgac 13620 aaggtgtcct gtccccgcac cctcatcgtg cgccacgaga cccaggaggt gctgatcaag 13680 accgtgcata tgatgcccat gcaggtgcag gtgcaggtga acaggcaggc ggtggcactg 13740 ccctacaaga agtacgggct ggaggtgtac cagtctggca tcaactacgt ggtggacatc 13800 cccgagctgg gtgtcctcgt ctcctacaat ggcctgtcct tctccgtcag gctgccctac 13860 caccggtttg gcaacaacac caagggccag tgtggcacct gcaccaacac cacctccgac 13920 gactgcattc tgcccagcgg ggagatcgtc tccaactgtg aggctgcggc tgaccagtgg 13980 ctggtgaacg acccctccaa gccacactgc ccccacagca gctccacgac caagcgcccg 14040 gccgtcactg tgcccggggg cggtaaaacg accccacaca aggactgcac cccatctccc 14100 ctctgccagc tcatcaagga cagcctgttt gcccagtgcc acgcactggt gcccccgcag 14160 cactactacg atgcctgcgt gttcgacagc tgcttcatgc cgggctcgag cctggagtgc 14220 gccagtctgc aggcctacgc agccctctgt gcccagcaga acatctgcct cgactggcgg 14280 i aaccacacgc atggggcctg cttggtggag tgcccatctc acagggagta ccaggcctgt 14340 ggccctgcag aagagcccac gtgcaaatcc agctcctccc agcagaacaa cacagtcctg 14400 gtggaaggct gcttctgtcc tgagggcacc atgaactacg ctcctggctt tgatgtctgc 14460 gtgaagacct gcggctgtgt gggacctgac aatgtgccca gagagtttgg ggagcacttc 14520 gagttcgact gcaagaactg tgtctgcctg gagggtggaa gtggcatcat ctgccaaccc 14580 aagaggtgca gccagaagcc cgttacccac tgcgtggaag acggcaccta cctcgccacg 14640 gaggtcaacc ctgccgacac ctgctgcaac attaccgtct gcaagtgcaa caccagcctg 14700 tgcaaagaga agccctccgt gtgcccgctg ggattcgaag tgaagagcaa gatggtgcct 14760 ggaaggtgct gtcccttcta ctggtgtgag tccaaggggg tgtgtgttca cgggaatgct 14820 gagtaccagc ccggttctcc agtttattcc tccaagtgcc aggactgcgt gtgcacggac 14880 aaggtggaca acaacaccct gctcaacgtc atcgcctgca cccacgtgcc ctgcaacacc 14940 tcctgcagcc ctggcttcga actcatggag gcccccgggg agtgctgtaa gaagtgtgaa 15000 cagacgcact gtatcatcaa acggcccgac aaccagcacg tcatcctgaa gcccggggac 15060 ttcaagagcg acccgaagaa caactgcaca ttcttcagct gcgtgaagat ccacaaccag 15120 ctcatctcgt ccgtctccaa catcacctgc cccaactttg atgccagcat ttgcatcccg 15180 ggctccatca cattcatgcc caatggatgc tgcaagacct gcacccctcg caatgagacc 15240 agggtgccct gctccaccgt ccccgtcacc acggaggttt cgtacgccgg ctgcaccaag 15300 accgtcctca tgaatcattg ctccgggtcc tgcgggacat ttgtcatgta ctcggccaag 15360 gcccaggccc tggaccacag ctgctcctgc tgcaaagagg agaaaaccag ccagcgtgag 15420 gtggtcctga gctgccccaa tggcggctcg ctgacacaca cctacaccca catcgagagc 15480 tgccagtgcc aggacaccgt ctgcgggctc cccaccggca cctcccgccg ggcccggcgc 15540 tcccctaggc atctggggag cgggtgagcg gggtgggcac agcccccttc actgccctcg 15600 acagctttac ctcccccgga ccctctgagc ctcctaagct cggcttcctc tcttcagata 15660 tttattgtct gagtctttgt tcagtccttg ctttccaata ataaactcag ggggacatgc 15720 <210> 37 <211> 3941 <212> DNA
<213> Human <400> 37 accatctact ccacagtcag ctcatccaca actgccatca cctcaccttt cactaccgca 60 gagactgggg tgacttccac accttcatcc ccatcttctc tgagtacaga catcccgacc 120 acatccctaagaactctcaccccattatctttgagcaccagcacttcattgactacaacc 180 acagaccttccctctatacccactgatatcagtagcttaccaaccccaatacacatcatt 240 tcatcttctccctccatccaaagtacagaaacctcatcccttgtgggcaccacctctccc 300 accatgtccactgtgagagcgaccctcagaagtactgagaacaccccaatcagttccttt 360 agcacaagtattgttgttacacctgaaaccccaacaacacaggcccctcctgtactgatg 420 tctgccactgggacccaaacatcccctgtacctactactgtcacctttggaagtatggat 480 tcctctacgtccactcttcatactcttactccatcaacagccttgagcaagatcatgtca 540 acatcacagtttcctattcctagcacacattcctccacccttcaaacaactccttcaatc 600 ccctctttgcaaacttcactcacatctacaagtgagttcactacagaatctttcactagg 660 ggaagtacgtctacaaatgcaatcttgacttcttttagtaccatcatctggtcctcaaca 720 cccactattatcatgtcctcttctccatcttctgccagcataactccagtgttcgctact 780 accattcattctgttccttcgtcaccatacattttcagtacagaaaatgtgggctccgct 840 tctatcacagcctttcctagtctctcttcctcttcaactaccagcacttctccaaccagc 900 tcctctctgaccacagctctcactgaaataacccccttttcttatatttcccttccctcc 960 accacaccctgtccaggaactataacaattaccatagtccctgcctcccccactgatcca 1020 tgtgttgaaatggatcccagcactgaagctacttctcctcccaccactccattaacagtc 1080 tttccctttactactgaaatggtcacctgtcctagctccatcagtatgcaaactactctt 1140 gctacacatatggacacttcttccatgacgccagaaagtgagtccagcatcatacctaat 1200 gcttccagttccactggcactgggactgtacccacaaacacagttttcacaagtactcga 1260 ctgcccaccagtgagacctggctgagcaacaactctgtgatccccacacctcttcctggc 1320 gtctctaccatcccgctcaccatgaaaccaagcagtagcctcccgaccatcctgaggact 1380 tcaagcaagtcaacacacccatccccacccaccgccaggacttcagagacatcagtggcc 1440 actacccagactcctaccacccttacaacgcgcaggacaactcccatcacttcttggatg 1500 accacacagtccacgttgaccaccactgcaggcacctgtgacaatggtggcacctgggaa 1560 cagggccagtgtgcttgccttccggggttttctggggaccgctgtcagctccagaccaga 1620 tgccagaacgggggccagtgggatggcctcaagtgccagtgccccagcaccttctatggt 1680 tccagttgtgagtttgctgtggaacaggtggatctagatgtagtggagaccgaggtgggc 1740 atggaagtgtctgtggatcagcagttctcgccggacctcaatgacaacacttcccaggcc 1800 tacagggatttcaacaagaccttctggaatcagatgcagaagatttttgcagacatgcag 1860 ggcttcacct tcaagggtgt ggagatcctg tccctgagga atggcagcat cgtggtggac 1920 tacctggtcc tgctggagat gcccttcagc ccccagctgg agagcgagta tgagcaggtg 1980 aagaccacgc tgaaggaggg gctccagaac gccagccagg atgcgaacag ctgccaggac 2040 tcccagaccctgtgttttaagcctgactccatcaaggtgaacaacaacagcaagacagag2100 ctgaccccggaagccatctgccgccgcgccgctcccacgggctatgaagagttctacttc2160 cctctggtggaggccacccggctccgctgtgtcaccaaatgcacgtcgggcgtggacaac2220 gccatcgactgtcaccagggccagtgcgttctagagacgagcggtcccgcgtgtcgctgc2280 tactccaccgacacgcactggttctctggcccgcgctgcgaggtggccgtccactggagg2340 gcgctggtcgggggcctgacggccggcgccgcgctgctggtgctgctgctgctggcgctg2400 ggcgtccgggcggtgcgctccggatggtggggcggccagcgccgaggccggtcctgggac2460 caggacaggaaatggttcgagacctgggatgaggaagtcgtgggcactttttcaaactgg2520 ggtttcgaggacgacggaacagacaaggatacaaatttccatgtggccttggagaacgtg2580 gacaccactatgaaggtgcacatcaagagacccgagatgacctcgtcctcagtgtgagcc2640 ctgcggggccccttcaccaceccctccgccctgccccggacacaagggtctgcattgcgt2700 ccatttcaagaggtggccccaggacgcgggcagcccaggctcctgctgttcttgggcaag2760 atgagactgttcccccaaatcccatccttctccttccaacttggctgaaacccacctgga2820 gacgcagttcacgtccaggctcttccactgtggaatcttgggcaagtcagtaacgagcct2880 cagtttcctcacctgcaaaacgggtacagcattcctgtatgatagctcacgccgttgttg2940 tgaaaaccacatagacttggtcaattctcggtcctactctgccctcccgtctcagccctc3000 gtgttgccattgcctctctcggatcctccaatcctcacgtccttcacctggtctctggcc3060 ctggttcttattttctctcaattccctactgcctgtttcttactttgaacctggaggcag3120 cctgcagccccatcccatctcctgccctctcotgatctaactccctgctgcatctcttgc3180 tctcattccttagacgtcctccccttttgaccccgttccttcatccatcctgcaccccag3240 tcccccagccctaaatcctccctcctctcctcacatcctggtccctagcaaggtatagat3300 agcctctgtgtcttaggataccccgggtgctgttccctcggtcaccctgttgcccagttc3360 cccgtttctcttgctctcattccttgtatcttctccccttctgagcccgtccattcatcg3420 gttctgcccccgactcccccagccctaaataccccagctcctaattcccccctcaccccg3480 ttgctcaattccccgtttctcttgctctcattccttgtatcttctccccttctgagcctg3540 tccattcatc ggtggttctg cccctactcc eccagcccta aataccccag ctgctgttcc 3600 tccccatcac ccagccaccg gattctccat tcaccccttt ctctcacccc tggagccccg 3660 tgggtggggg cagggcatga gttccccagt ccccaaggaa aggcagcccc ctcagtctcc 3720 ctcctcctca ttcccttcca tctccctccc ctctgccttt taaacccatc ccctccgatt 3780 cccctcctcc cccctctctc cctggtgtca actcgattcc tgcggtaact ctgagccctg 3840 aaatcctcag tctccttggc ggggaagatt ggctttgggg acaggaagtc ggcacatctc 3900 caggtctcca tgtgcacaat atagagttta ttgtaaaaag c 3941 <210> 38 <21l> 5992 <212> DNA
<213> Human <400> 38 aaattgctgt gaccgcagca tctctaggaa gacgctttat tcctgaagga cactgactgt 60 cacttgggaa ccaagaagcc ctctgcagtc atgagctctg acgcagaaat ggccattttt 120 ggagaagcagctccctacctccggaaaccagagaaggagagaatcgaggctcaaaatcgt180 ccattcgattccaagaaagcctgctttgtagcggataataaggaaatgtatgtgaaaggc240 atgatccagactagggaaaatgacaaagtcatagtcaagaccctcgatgaccggatgctc300 actctgaacaatgaccaggtcttccccatgaaccctcccaaatttgacaagatcgaggac360 atggccatgatgactcacctgcatgaacctgctgttctgtacaacctcaaagagcgctat420 gcagcctggatgatctacacctactcaggcctcttctgtgtcaccgtcaacccctacaag480 tggctgccggtgtacaagcccgaggtggtggctgcctacagaggcaaaaagcgccaggag540 gccccgccccacatcttctccatctctgacaatgcctatcagttcatgctgactgatcga600 gacaaccagtctatcctcatcaccggagaatccggggctgggaagactgtgaacaccaag660 cgtgtcatccagtattttgcaacaattgcagttaccggggacaagaagaaggagacacag720 ccaggcaaaatgcagggaaccctagaggatcagatcatccaggccaacccactgetggag780 gcctttggaaatgccaagactgtgaggaatgacaactcctcaagatttgggaagttcatt840 cggattcattttggagccacaggaaagctggcatcggcagacatcgaaacttatctgtta900 gaaaaatccagagtgacgtttcaattatccagtgagagaagctatcatattttctaccaa960 attatgtcaaacaagaagccagaactaattgacctgcttctgatctccaccaaccccttc1020 gacttcccct tcgtgagcca aggagaggtc acggtagcca gtatcgatga cagtgaagaa 1080 ctgctggcga cagataatgc cattgacatc ctgggcttca gctcagagga gaaagtcggg 1140 atctacaaac tgacgggagc cgtgatgcat tatgggaaca tgaagttcaa gcagaagcag 1200 cgtgaggagc aggcggagcc agacggcacc gaagtggctg acaaagccgg atacctgatg 1260 ggactgaattctgcagaaatgctgaagggcctgtgctgtccaagggtgaaggttggcaat1320 gaatatgtcactaaagggcaaaatgtccagcaggtgaccaattcggtgggtgctctggcc1380 aaagccgtctacgagaagatgttcctgtggatggtcacccgcatcaaccagcagttggac1440 accaagcagcccaggcagtacttcatcggggtcttggacattgctggctttgagatcttt1500 gatttcaacagcctggagcagctgtgcatcaacttcaccaatgagaaactgcaacagttt1560 ttcaaccaccacatgttcgtgctggagcaggaagagtacaagaaggaaggcatcgagtgg1620 gagttcattgacttcggaatggacctggctgcctgcatcgagctcatcgagaagcctatg1680 ggcatcttctccatcctggaagaggagtgcatgttccccaaggcaacagacacctccttc1740 aagaacaagctgtatgaccagcatcttggaaaatccaacaacttccagaagcccaagcct1800 gccaaaggcaaggctgaggctcacttctcgctggtgcactatgccggcaccgtggactac1860 aacatcgccggctggctggacaaaaacaaggaccccctgaatgagactgtggtggggctg1920 taccagaagtcttcgctgaagcttctctccttccttttttccaactatgctggtgcagag1980 acaggtgactccggaggaagcaagaagggcgggaagaagaagggctcctctttccagacc2040 gtgtcggccgtgttcagggaaaatttaaacaaattgatgactaacttaaggagcacccac2100 cctcactttgtacgatgtctgattcccaatgagaccaagactcctggtgtgatggaccac2160 tacttggtcatgcaccagctgcgctgtaacggggtcctcgagggcatccggatttgcagg2220 aagggattccccagccggatcctctatgctgacttcaagcagcggtaccggatcctcaat2280 gccagtgctatccctgaagggcagttcattgacagcaaaaatgcctcagagaagctcctc2340 aactccatcgatgtggaccgggagcagttcaggttcggcaacaccaaggtgtttttcaaa2400 gctgggctcctgggacttttggaggagatgagagatgagaagctggtgacgctgatgaca2460 agcacgcaggcggtgtgcagggggtacctgatgcgggtggagttcaagaagatgatggag2520 aggagggactccatcttctgcatccaatacaacatccgctcttttatgaacgtcaagcac2580 tggccctggatgaacctgttcttcaaaatcaagcccctgctgaagagtgcagaggccgag2640 aaggagatggccaccatgaaggaagactttgagaggaccaaggaagaactggcccgatct2700 gaggctcgccggaaggagctggaggagaaaatggtctccctcctgcaggagaagaatgac2760 ctccaattgcaggtccagtctgaaacagaaaatctgatggacgctgaggaacggtgtgaa2820 ggactcatcaaaagcaagatcctactggaagcaaaagtcaaggagctgacggagagattg2880 gaagaggaagaggagatgaattctgaattggttgccaagaagaggaatctggaagataaa2940 tgctcctctctcaagagagacattgatgatctggagctgaccttgacgaaagttgaaaag3000 gagaagcatg ccacagagaa caaggtaaag aatctttccg aagaaatgac agcacttgaa 3060 gaaaacattt ccaaattgac caaagaaaag aaatctctac aggaggccca tcagcaaaca 3120 ctggatgatc ttcaggtgga agaagataaa gtcaatggtc taatcaaaat aaatgccaag 3180 cttgaacagc aaacagatga tcttgagggt tccttagagc aggagaagaa actgcgggcg 3240 gacttggaaa gggcgaagag gaagctggaa ggagatctga aaatgtccca ggaatccatt 3300 atggatctag aaaatgaaaa gcagcaaata gaagagaaat tgaaaaagaa ggagtttgaa 3360 ctcagtcagt tacaagccag aatagatgac gaacaagtcc acagtttgca gtttcaaaag 3420 aagattaaag agctgcaagc ccgcatagaa gagctggagg aggaaattga agcggaacac 3480 acgctcagag ccaagattga gaagcagcgc tcagatctgg ccagggaact ggaggagatc 3540 agcgagaggc tggaagaagc cagtggggcc acttcagccc agattgagat gaacaagaag 3600 agggaggctg agttccagaa aatgcgcagg gacctggagg aggccaccct gcagcacgaa 3660 gccacagcag ccaccctgag gaagaagcaa gcagatagtg tggccgagct tggggagcag 3720 attgacaacc tgcagcgggt gaagcagaag ctggagaagg agaagagcga gctgaagatg 3780 gagatcgacg acatggccag caacatcgag gctctctcca agtcaaagag taacatagaa 3840 agaacgtgcc ggacggtaga agatcaattt agtgaaatca aagccaagga cgagcaacag 3900 acacagttga tccatgatct gaacatgcag aaagcaagac tgcagaccca aaatggggag 3960 ctgagccacc gagtggaaga gaaggagtct ctgatttcac agctgaccaa aagcaagcag 4020 gccctcaccc agcagctgga ggagcttaag aggcaaatgg aagaagaaac caaggccaag 4080 aacgccatgg cgcacgccct gcagtcctcc cgccacgact gtgacctgct gcgggaacag 4140 tatgaggagg agcaggaagc caaggccgag ctgcagaggg cgctgtccaa ggccaacagt 4200 gaggttgccc agtggaagac caaatacgag acggacgcca ttcagcgcac agaagagctg 4260 gaggaggcca agaaaaaact ggcccagagg ctccaggaag cagaggagaa gacggagacg 4320 gcgaactcca agtgcgcatc gttggagaaa accaagcaga ggctgcaggg agaggtggag 4380 gatctgatgc gggatctgga gcgctcccac accgcctgtg ccacactgga caagaagcag 4440 aggaacttcg acaaggtcct tgcagagtgg aagcaaaagc tggacgaaag ccaggctgag 4500 ctggaagctg ctcagaagga gtccaggtca ctcagcactg aactcttcaa gatgaggaat 4560 gcctatgagg aggtggtgga ccagttagag acactgaggc gagagaacaa aaatctgcaa 4620 gaagagattt ccgacttaac tgagcagatt gcagaaactg gcaagaatct tcaggaagcg 4680 gaaaagacca agaagctagt ggagcaggaa aagtcagatc tgcaggtcgc cttagaagaa 4740 gtggagggtt ccttggaaca cgaggagagc aagatcttgc gcgtgcagct agagctgagc 4800 caggtgaaatccgagctagaccgcaaggtcattgagaaggatgaagaaatcgagcagcta4860 aaaagaaacagccagcgggcagcagaggccctgcagagcgtgctggatgctgaaatccgc4920 agccggaacgacgccctgaggctaaagaagaagatggagggagaccttaatgagatggag4980 attcagctgggccactccaaccgccagatggcagagacccagaggcatctgcgcacggtc5040 cagggccagctcaaggactcccagctgcatctcgatgacgccctgaggagcaatgaggac5100 ctcaaggagcagctggccatcgtggagcgcaggaatggcctcctgctggaggagctggag5160 gaaatgaaggtggccctggaacagacggagcggacccgcaggctgtcagagcaggagctg5220 ctggacgccagcgaccgcgtgcagctcctgcactcccagaacacaagcctgataaatacc5280 aagaaaaaactggaggctgacatagctcagtgccaggcagaggtggagaactcgatccag5340 gagtccaggaacgcagaggagaaggccaagaaggccatcacggatgctgccatgatggct5400 gaggagctaaagaaggaacaggacaccagcgcccacctggagcggatgaagaagaacctg5460 gagcagacggtgaaggacctgcagcaccgtctagatgaggctgaacaactggcgctgaag5520 ggcgggaagaagcagatccagaaactggagaaccgggtgcgggagctggaaaatgagctt5580 gatgtggaacagaagaggggagctgaagccctgaagggagcccacaagtacgaacgcaaa5640 gtcaaggagatgacttaccaggctgaggaggaccgcaagaatatccttaggctccaggac5700 ctggtggacaagctgcaggccaaagtgaagtcttacaagaggcaggctgaggaggcggag5760 gagcaggccaacacgcagctgtccagatgccggagagtccagcatgagctagaggaggcc5820 gcggagagggcggacatcgctgagtcccaggtcaacaagctgagggccaagagccgagac5880 gtgggcagccagaagatggaagaatgaggctcacctgatgctcgttgccatgggacacct5940 ccgagagagtggagggaaaatgtgtgagaaataaattctcctaaatactcgg 5992 <210> 39 <211> 661 <2l2> DNA
<213> Human <400> 39 ggagtggcag ccggagtctg aactgtcctg ggggaccaag caggagctta agatgggcaa 60 gacctggggc cctgggcaga cgcatcaaag caggcagaag caggcatggc cagcaggaag 120 accaagaaga aggaaggggg tgccctccgg gcccagagag cctcatccaa tgtcttctcc 180 aactttgagc agactcagat ccaggagttc aaggaggcat tcacactcat ggatcagaac 240 cgagatggct tcattgacaa ggaggacctg aaggacacct atgcctccct gggcaagacc 300 aacgtcaagg acgacgagct ggacgccatg ctcaaagagg cctcggggcc catcaacttc 360 accatgtttc tgaacctgtt tggggagaag ctgagcggta ccgacgccga ggagaccatt 420 cttaacgcct tcaagatgct ggacccggac gggaaaggga aaatcaacaa ggagtacatc 480 aagcgtctgc tgatgtccca ggctgacaag atgacggcgg aagaggtgga ccagatgttc 540 cagttcgcct ccatcgatgt ggcgggcaac ctggactaca aggcgctcag ctacgtgatc 600 acccacgggg aggagaagga ggagtgagac cca.gccgggt caataaacct ggacgcttgg 660 a 661 <210> 40 <211> 5749 <212> DNA
<2l3> Human <400>

cgcgggagccaacttcaggctgctcagaggaagcccgtgcagtcagtcacctgggtgcaa60 gagcgttgctgcctcgggctctcccgctgcagggagagcggcactcgctggcctggatgt120 ggttggatttaggggggctccgcagcaggggtttcgtggcggtggcaagcgctgcaacag180 gtagacggcgagagacggaccccggccgaggcagggatggagaccaaaggctaccacagt240 ctccctgaaggtctagatatggaaagacggtggggtcaagtttctcaggctgtggagcgt300 tcttccctgggacctacagagaggaccgatgagaataactacatggagattgtcaacgta360 agctgtgtttccggtgctattccaaacaacagtactcaaggaagcagcaaagaaaaacaa420 gaactactcccttgccttcagcaagacaataatcggcctgggattttaacatctgatatt480 aaaactgagctggaatctaaggaactttcagcaactgtagctgagtccatgggtttatat540 atggattctgtaagagatgctgactattcctatgagcagcagaaccaacaaggaagcatg600 agtccagctaagatttatcagaatgttgaacagctggtgaaattttacaaaggaaatggc660 catcgtccttccactctaagttgtgtgaacacgcccttgagatcatttatgtctgactct720 gggagctccgtgaatggtggcgtcatgcgcgccattgttaaaagccctatcatgtgtcat780 ' gagaaaagcccgtctgtttgcagccctctgaacatgacatcttcggtttgcagccctgct840 ggaatcaactctgtgtcctccaccacagccagctttggcagttttccagtgcacagccca900 atcacccagggaactcctctgacatgctcccctaatgctgaaaatcgaggctccaggtcg960 cacagccctgcacatgctagcaatgtgggctctcctctctcaagtccgttaagtagcatg1020 aaatcctcaa tttccagccc tccaagtcac tgcagtgtaa aatctccagt ctccagtccc 1080 aataatgtca ctctgagatc ctctgtgtct agccctgcaa atattaacaa ctcaaggtgc 1140 tctgtttcca gcccttcgaa cactaataac agatccacgc tttccagtcc ggcagccagt 1200 actgtgggat ctatctgtag ccctgtaaac aatgccttca gctacactgc ttctggcacc 1260 tctgctggat ccagtacatt gegggatgtg gttcccagtc cagacacgca ggagaaaggt 1320 gctcaagagg tcccttttcc taagactgag gaagtagaga gtgccatctc aaatggtgtg 1380 actggccagc ttaatattgt ccagtacata aaaccagaac cagatggagc ttttagcagc 1440 tcatgtctag gaggaaatag caaaataaat tcggattctt cattctcagt accaataaag 1500 caagaatcaa ccaagcattc atgttcaggc acctctttta aagggaatcc aacagtaaac 1560 ccgtttccat ttatggatgg ctcgtatttt tcctttatgg atgataaaga ctattattcc 1620 ctatcaggaa ttttaggacc acctgtgccc ggctttgatg gtaactgtga aggcagcgga 1680 ttcccagtgg gtattaaaca agaaccagat gacgggagct attacccaga ggccagcatc 1740 ccttcctctg ctattgttgg ggtgaattca ggtggacagt ccttccacta caggattggt 1800 gctcaaggta caatatcttt atcacgatcg gctagagacc aatctttcca acacctgagt 1860 tcctttcctc ctgtcaatac tttagtggag tcatggaaat cacacggcga cctgtcgtct 1920 agaagaagtg atgggtatcc ggtcttagaa;tacattccag aaaatgtatc aagctctact 1980 ttacgaagtg tttctactgg atcttcaaga ccttcaaaaa tatgtttggt gtgtggggat 2040 gaggcttcag gatgccatta tggggtagtc acctgtggca gctgcaaagt tttcttcaaa 2100 agagcagtgg aagggcaaca caactattta tgtgctggaa gaaatgattg catcattgat 2160 aagattcgac gaaagaattg tcctgcttgc agacttcaga aatgtcttca agctggaatg 2220 aatttaggag cacgaaagtc aaagaagttg ggaaagttaa aagggattca cgaggagcag 2280 ccacagcagc agcagccccc acccccaccc ccacccccgc aaagcccaga ggaagggaca 2340 acgtacatcg ctcctgcaaa agaaccctcg gtcaacacag cactggttcc tcagctctcc 2400 acaatctcac gagcgctcac accttccccc gttatggtcc ttgaaaacat tgaacctgaa 2460 attgtatatg caggctatga cagctcaaaa ccagatacag ccgaaaatct gctctccacg 2520 ctcaaccgct tagcaggcaa acagatgatc caagtcgtga agtgggcaaa ggtacttcca 2580 ggatttaaaa acttgcctct tgaggaccaa attaccctaa tccagtattc ttggatgtgt 2640 ctatcatcat ttgccttgag ctggagatcg tacaaacata cgaacagcca atttctctat 2700 tttgcaccag acctagtctt taatgaagag aagatgcatc agtctgccat gtatgaacta 2760 tgccagggga tgcaccaaat cagccttcag ttcgttcgac tgcagctcac ctttgaagaa 2820 tacaccatca tgaaagtttt gctgctacta agcacaattc caaaggatgg cctcaaaagc 2880 caggctgcat ttgaagaaat gaggacaaat tacatcaaag aactgaggaa gatggtaact 2940 aagtgtcccaacaattctgggcagagctggcagaggttctaccaactgaccaagctgctg3000 gactccatgcatgacctggtgagcgacctgctggaattctgcttctacaccttccgagag3060 tcccatgcgctgaaggtagagttccccgcaatgctggtggagatcatcagcgaccagctg3120 cccaaggtggagtcggggaacgccaagccgctctacttccaccggaagtgactgcccgct3180 gcccagaagaactttgccttaagtttccctgtgttgttccacacccagaaggacccaaga3240 aaacctgtttttaacatgtgatggttgattcacacttgttcaacagtttctcaagtttaa3300 agtcatgtcagaggtttggagccgggaaagctgtttttccgtggatttggcgagaccaga3360 gcagtctgaaggattccccacctccaatcccccagcgcttagaaacatgttcctgttcct3420 cgggatgaaaagccatatctagtcaataactctgattttgatattttcacagatggaaga3480 agttttaactatgccgtgtagtttctggtatcgttcgcttgttttaaaagggttcaagga3540 ctaacgaacgttttaaagcttacccttggtttgcacataaaacgtatagtcaatatgggg3600 cattaatattcttttgttattaaaaaaacacaaaaaaataataaaaaaatatatacagat3660 tcctgttgtgtaataacagaactcgtggcgtggggcagcagctgcctctgagccctcgct3720 cgtccacggtcttctgcatcactggtatacacactcgttagcgtccatttcttatttaat3780 tagaatggataagatgatgttaaatgccttggtttgatttctagtatctattgtgttggc3840 tttacaaataattttttgcagtcttttgctgtgctgtacattactgtatgtataaattat3900 gaaggacctgaaataaggtataaggatcttttgtaaatgagacacatacaaaaaaaatct3960 ttaatggttaataggatgaatgggaaagtatttttgaaagaattctattttgctggagac4020 tatttaagtactatctttgtctaaacaa~ggtaatttttttttgtaaagtgcaatgtcctg4080 catgcataatgaaccgtttacagtgtatttaagaaagggaaagctgtgccttttttagct4140 tcatatctaatttaccattattttacagtctctgttgtaaataaccacactgaaacctct4200 tcggttgtcttgaaacctttctactttttctgtactttttgttttgttcttggtctcccg4260 cttggggcatttgtgggactccagcacgttttctggcttctgcttcatcctgctccatcg4320 gggaatgacacactgcggtgtctgcagctcctggaaggtgtcatttgacaacacatgtgg4380 gagaggaggtccttggagtgctgcagctttgggaaagcctgcctcgtttcccttttcctc4440 tagaagcagaaccagctctacgagagtgagactgggaacttgatggctcagagagcatct4500 tttcctcccattttagaaaatcagattttctcctgtgggaaaaaaaaattccatgcactc4560 tctctctgttaaagatcagctattcccttctgatcttggaaagaggttctgcactcctgg4620 aaccggtcacaggaacgcacagatcatggcaggatgcgctgggacggcccatcttggcaa4680 ggttcagtctgaatggcatggagaccgggagatagaggggttttagatttttaaaaggta4740 ggttttaaaaataagttttatacataaacagttttggagaaaaattacagatcatataag4800 r caagacagtggcactaaaatgtttaattcattaatctgtttgtttggcactgatgcaatg4860 tatggcttttctcttgccccaaatcacaaacatatgtatctttggggaaactaacaatat4920 gattgcactaaataaactactttgaatagaggccaaattaatcttttaaaaatgatgata4980 atcatcaggtttactcagtgaaatcatattaattattttccaaaatctaaaagctgtagc5040 tggagaagcc catggccacg aggaagcagc aattaattag atcaacactt ttctccaggg 5100 ttcaccatgc aggcaacatt accttgtctt tcaaaagaca cctgccttag tgcaagggga 5160 aacctgtgaaagctgcactcagagggaggagtctttcttacataatttgcaatttcagga5220 atttaatttataggcagatctttaaatacagtcaacttacggtgcacagtaatatgaaag5280 ccacactttgaaggtaataaatacacagcatgcagactgggagttgctagcaaacaaatg5340 gcttacttacaaaagcagcttttagttcagacttagtttttataaaatgagaattctgac5400 ttacttaaccaggtttgggatggagatggtctgcatcagctttttgtattaacaaagtta5460 ctggctctttgtgtgtctccaggtaactttgcttgattaaacagcaaagccatattctaa5520 attcactgttgaatgcctgtcccagtccaaattgtctgtctgctcttatttttgtaccat5580 attgctcttaaaaatcttggtttggtacagttcataattcaccaaaaagttcatataatt5640 taaagaaacactaaattagtttaaaatgaagcaatttatatctttatgcaaaaacatatg5700 tctgtctttgcaaaggactgtaagcagattacaataaatcctttacttt 5749 <210> 41 <211> 2306 <212> DNA
<213> Human <400>

tcatcatccaagtttgtagttcatttaaaaatacaacattaaacacattttgctaggatg 60 tcaaatagtcacagttctaagtagttggaaacaaaattgacgcatgttaatctatgcaaa 120 gagaaaggaaaggatgaggtgatgtattgactcaaggttcattcttgctgcaattgaaca 180 tcctcaagagttgggatggaaatggtgatttttacatgtgtcctggaaagatattaaagt 240 aattcaaatcttccccaaaggggaaaggaagagagtgatactgacctttttaagtcatag 300 accaaagtctgctgtagaacaaatatgggaggacaaagaatcgcaaattcttcaaatgac 360 tattatcagtattattaacatgcgatgccacaggtatgaaagtcttgccttatttcacaa 420 ttttaaaaggtagctgtgcagatgtggatcaacatttgtttaaaataaagtattaatact 480 ttaaagtcaaataagatatagtgtttacattctttaggtcctgaggggcagggggatctg 540 tgatataacaaaatagcaaaagcggtaatttccttaatgttatttttctgattggtaatt600 atttttaacagtacttaattattctatgtcgtgagacactaaaatcaaaaacgggaatct660 catttagactttaatttttttgagattatcggcggcacaatcactttgtagaaactgtaa720 aaaataaaagtatctcctagtcccttaattttttcataaatatttctggcttttgagtag780 tgtatttatattgtatatcatactttcaactgtagacaattatgatgctaatttattgtt840 tcttggtttcacctttgtataagatatagccaagactgaagaaaccaaatatatgtgttt900 actgtagcatgtcttcaaattagtggaacttagttcagggacatagaagagtcttaatga960 attaaaatcattcacttgattaaatgtctgtaaatcttcatcattcctactgtagtttat1020 ttaatatctattgtaaattatgtgacttgtagcttcctctggttttcaagtaaactcaac1080 aaggtggagtcttacctggttttcctttccaagcattgtaaattgtataccaaagatatt1140 agttattacttctgtgtgtacaaagaggattattttattatgtttattaatcacctctaa1200 tactcatccacatgaagggtacacattaggtaagctgggcgttgactcatgcgcagtctc1260 agtcacccgtgttatcttcgtggctcaaaggacaatgcaaaatcgccgatcagagctcat1320 acccaaagcattacagagaacagcagcatcattgccctccccagctgaaaaacaagttgg1380 ctagaagatacatggagaggaatggtgtggtcaacagttaatgaaacggttctatcatgc1440 atgtgtaatgtggatggagacaattataagatttgactataactatttggagggtcttta1500 acattgccaaaaaaacaaatatgttgatttttattttattttattttttattttaagagg1560 cgggatcttgatctcacatgttgcccaggctggccttgaactcctgggctcaagcattcc1620 tcctgcctcagcctcccccatagctgggactaggggtgcatgccagcatacctggctacg1680 ttgactcttaaaatctatgttctcttattttaaagatacagtgctccccactgaaaatta1740 aacctaaaaaatgtcacatattggtatgttgttaacctggtagattaaatcatgagaatg1800 attagaaagacgggcaacacagcgggttacatccacactgctgatcacaccaacgacagg1860 agctgataag caagaaagcg tcacagccag cgtctgttca cccaaggttg acaagtgaag 1920 tttctctaat gttgattgtt agccgatttg taacctggca tttacttagc aactgcctta 1980 tcaattacag gatttgccgg taaaagcaga ctcaaatata aaggtttttg gcttaacttg 2040 gtttattata gttgctctat gtttgtaaac agacaatctc taatgtctga ttatttgtat 2100 cacagatctg cagctgcctt ggacttgaat ccatgcaatg tttagagtgt gaagtcagtt 2160 acttgttgat gttttcttac tgtatcaatg aaatacatat tgtcatgtca gttcttgcca 2220 ggaacttctc aacaaaatgg aatttttttt ttcagtattt caataaatat tgatatgccc 2280 agcctgataa aaaaaaaaaa aaaaaa 2306 <210> 42 <211> 7609 <212> DNA
<213> Human <400>

atctaccaccttaaaaccctgatctagaaaaaatatatattcatgataggaagttataac 60 taagaaaatttatttgcctcttaatgctcctgaatgaaagaaattatccctttgttcttt 120 gggaggacttgtgtatctgagattgttgtaataatcagtcattttattaaaaccttgaca 180 tgatcaccagggaggaaaaatagagcaatagtcaaaacctgtgtgttagtccaagatgac 240 ttctgaagaaatgacagcttctgttctcatacctgtgactcagagaaaagtggtttctgc 300 ccagtcggctgcagatgaaagtagtgaaaaggtctcagacatcaatatttcaaaagcaca 360 tactgtcagacgaagtggggagacttctcataccatctcacaactgaacaaacttaaaga 420 agaaccttctggaagcaacttgccaaagattctctcaatagcgagggagaaaatagtgag 480 tgatgagaacagtaatgaaaaatgttgggagaaaatcatgccagattctgcgaaaaacct 540 taacattaactgcaacaacatattgagaaaccatcagcatggccttcctcagagacaatt 600 ttatgaaatgtacaactctgttgctgaggaagacttgtgtttagaaactggaattccttc 660 tccactggaaagaaaggtgttccctggaattcaactggaactagacagaccttccatggg 720 cattagtcctttaggaaatcagtcagtgatcatagagacaggcagagcacaccctgacag 780 cagaagggcagtatttcattttcattatgaagttgacagaagaatgtcagacactttctg 840 taccctatcagaaaacttaattttagacgattgtggaaattgtgtaccactacctggggg 900 tgaggagaagcaaaagaaaaactatgtggcatatacctgtaaactgatggaattggccaa960 aaattgtgataataagaatgagcagctgcagtgtgatcattgtgacaccttgaatgataa1020 atacttttgctttgaaggctcttgtgagaaggttgacatggtatattcaggtgatagctt1080 ttgtaggaaagactttactgacagtcaagctgccaagacctttttgagccattttgagga1140 cttccctgataattgtgatgatgtagaagaagacgcttttaaaagcaaaaaggagcgatc1200 cactttgttagtcaggagattctgtaaaaatgacagagaagttaagaaatctgtgtatac1260 tggaacaagagcaattgtgagaactctgccttctggccacattgggctgactgcatggag1320 ttacatagatcagaagagaaatggtcccttactgccttgtgggagagtaatggaaccccc1380 gtcaacagtggagataaggcaagatgggagccaacgtctgtcagaagcccagtggtatcc1440 tatctacaatgcagtgagaagagaagaaacagaaaatacagttggatctctactccattt1500 cctcaccaag ctcccagcct ccgagacagc ccatggaagg ataagcgttg gtccatgctt 1560 aaagcaatgt gtccgagaca ctgtatgtga gtatcgcgcc accctccaaa ggacttcaat 1620 atcgcagtac atcaccggtt ctctcctaga agcaaccacg tctttgggag caagaagtgg 1680 ccttctcagt acttttggag gatccactgg acgaatgatg ctgaaagaac gccagccagg 1740 cccctctgtg gccaattcca atgccctccc ttcaagttca gctgggatca gcaaggagct 1800 gatcgatctg cagcctctca tccagttccc agaggaagtc gccagcatcc tgatggagca 1860 agagcagact atttaccgca gggtcttgcc agtcgactac ctttgcttct taacacggga 1920 cttgggcact cctgaatgcc agagctcctt gccctgcctc aaagcatcca tctcagcgtc 1980 gattcttacc actcagaatg gagagcacaa tgcccttgaa gatctggtga tgaggtttaa 2040 tgaggtgagc tcctgggtga catggctgat cctcacggca ggctccatgg aggagaagcg 2100 agaagtcttt tcatatttgg tgcatgtggc caaatgctgc tggaacatgg gcaactacaa 2160 cgctgtcatg gagttcttgg ctggcctcag gtcaagaaaa gttttaaaaa tgtggcagtt 2220 catggaccag tctgatattg agaccatgag gagcctgaag gatgctatgg cccagcatga 2280 gtcctcttgt gagtacagaa aggtggtgac acgtgccctg cacatccctg gctgtaaggt 2340 ggttccattc tgtggggtgt ttctgaagga gctctgtgaa gtgcttgacg gcgcctccgg 2400 tctcatgaag ctttgcccgc ggtacaattc ccaagaagaa actttagagt ttgtagcaga 2460 ttacagtgga caagataatt tcttacaacg agtgggacaa aatggcttaa agaattcgga 2520 gaaggagtcc actgtcaaca gcatctttca ggtcatccgg agctgcaatc gaagtctgga 2580 gacagacgag gaggacagcc ccagtgaagg gaacagctcc aggaaaagct ccttgaagga 2640 taaaagccga tggcagttta taattggaga tttgttggat tcagacaatg acatctttga 2700 gcaatccaaa gaatacgact ctcatggttc agaggactca cagaaggcct tcgaccatgg 2760 gacggagctc atcccttggt acgtgctgtc catccaagcc gatgtgcacc agttcctgct 2820 gcagggggcc acggtcatcc actacgacca ggacacacac ctctctgccc gctgcttcct 2880 ccagcttcag cccgacaata gcaccttgac ctgggtaaag cccacaactg cctccccagc 2940 cagcagtaaa gcaaaacttg gtgtacttaa taacacagct gagcctggaa aattcccact 3000 actgggtaat gctggattaa gtagcctgac ggaaggggtc ttggatcttt ttgcagtgaa 3060 ggctgtatac atgggccacc ctggcattga tatacacact gtgtgtgttc agaacaaact 3120 gggtagcatg ttcctgtcag agactggtgt gacattgctc tatgggcttc agaccacaga 3180 caacagatta ttgcacttcg tggcaccaaa gcacacagct aaaatgctct tcagcggatt 3240 attggaactc actagagctg tgagaaagat gaggaaattc cctgaccaaa gacagcagtg 3300 gctgcggaaa cagtacgtca gcctttatca ggaggatgga cggtatgaag gcccaacttt 3360 ggctcacgct gtggagttgt ttggtggcag acggtggagt gctcgaaacc ccagccccgg 3420 aacatcagca aagaatgctg agaagcccaa tatgcagaga aacaataccc tgggcataag 3480 cactaccaag aaaaagaaga aaatcctcat gaggggtgag agtggagagg taactgacga 3540 tgagatggcaacccgaaaggccaagatgcacaaagagtgtcgaagccggagtggttctga3600 tcctcaagacattaatgaacaagaagaatcagaggtgaatgccatcgctaaccctccaaa3660 ccccctcccttccagaagagcccactctttgaccacagctgggtcccccaacttggctgc3720 cgggacgtcatctcccatcaggccagtgtcctcccctgtgctgtcttcttcaaacaagag3780 cccatccagtgcttggagcagtagtagctggcacgggcggatcaaaggcggcatgaaggg3840 atttcagagcttcatggtttcagatagcaacatgagttttgttgaatttgttgagctgtt3900 caaatcattcagtgtcaggagccgcaaggacctgaaggatctgtttgatgtctatgcagt3960 gccctgcaaccgatctggctccgagtcagccccactctacaccaacctgacaattgatga4020 aaacaccagcgatcttcagcctgacctagatctgttgaccagaaatgtctcggatttggg4080 gttgttcattaagagtaaacagcagctatcggacaaccagaggcagatatctgatgccat4140 tgctgctgcaagcattgtgacaaatggcactgggattgagagcacatctctgggcatttt4200 tggggtgggcatacttcagctcaacgatttcctcgtgaattgccaaggagaacactgcac4260 ttatgatgaaatcctcagcatcatccagaagttcgagcctagcatcagtatgtgtcatca4320 gggactaatgtcatttgaagggtttgccaggtttctgatggataaagaaaattttgcctc4380 aaaaaatgatgagtcacaggagaacattaaagaactgcagctacccctctcatactatta4440 catcgaatcttcgcacaatacctacctcacgggccatcagctcaaaggagaatcctcggt4500 agaactctacagccaggtccttttgcaaggctgtcgaagtgtagaattggactgctggga4560 cggagacgatgggatgcccatcatttatcatggacatacgccgacaaccaagatcccctt4620 caaggaagtggttgaagccattgatcgcagtgccttcatcaactctgacctgccaatcat4680 catatcgattgagaaccactgttcattgcctcagcaacgaaaaatggcagaaattttcaa4740 gactgtgtttggagaaaagctggtgactaaattcttatttgagactgatttctcagatga4800 tccaatgcttccttcacctgaccaactcagaaagaaagttcttcttaaaaacaagaagct4860 aaaagcccatcagacgccagtggatatcttaaagcaaaaggctcatcagttagcatctat4920 gcaagtgcaggcttataatggtgggaatgccaacccccgacctgccaataatgaggaaga4980 ggaagatgaggaggacgaatatgattatgactatgaatccctttctgatgacaacattct5040 ggaagacaga cctgaaaata aatcatgtaa tgacaagctt cagtttgaat ataatgaaga 5100 aatcccaaag aggataaaga aagcagataa ctctgcttgc aacaaaggaa aggtttatga 5160 tatggaactg ggagaagaat tttatcttga tcagaataaa aaggaaagca gacagattgc 5220 accagagctt tctgaccttg taatctatcg tcaagcagta aaatttccag gactgtcaac 5280 tctaaatgca tctggctcta gcagaggaaa agaaaggaaa agcaggaagt ccatttttgg 5340 caacaatccg ggcagaatga gcccagggga gacagcatca tttaacaaaa catctggaaa 5400 aagttcctgt gaaggcattc gacagacctg ggaggaatct tcttcccccc tcaacccaac 5460 cacgtccctc agtgctatca ttagaactcc caaatgttat catatctcgt cgctgaatga 5520 aaatgccgcc aaacgtctgt gtcgcaggta ttctcagaaa ctgatccagc acaccgcctg 5580 tcagctgctg agaacttacc ctgctgccac ccgcatcgac tcttccaacc cgaaccccct 5640 catgttctgg ctccatggga tacagcttgt ggcactcaac taccagactg atgatctccc 5700 tttacattta aatgctgcaa tgtttgaggc aaatggtggt tgtggttatg tattgaaacc 5760 tccagttctg tgggacaaga actgccccat gtatcagaag ttttctccac tagaaagaga 5820 tctggacagc atggatcctg cagtctattc tttaactatt gtctctggtc agaatgtgtg 5880 ccccagtaat agcatgggaa gcccgtgcat tgaagtcgac gtcctgggca tgcctctgga 5940 cagctgccat ttccgcacaa agcccatcca tcgaaacacc ctgaacccca tgtggaacga 6000 gcagtttctg ttccgcgttc acttcgaaga tcttgtattt cttcgttttg cagttgtgga 6060 aaacaatagt tcagcggtaa ctgctcagag aatcattcca ctgaaagctt taaaacgagg. 6120 atatcgacat cttcagctgc gaaaccttca caatgaagtc ttggagattt ctagtttatt 6180 cattaacagc agaaggatgg aagaaaattc ctctggcaat accatgtcag cctcttcgat 6240 gtttaataca gaagaaagaa aatgtttgca gactcacaga gtcacggtgc atggggtccc 6300 agggccagag ccctttaccg ttttcactat taatggaggc accaaggcaa agcagcttct 6360 gcagcaaatt ctgacaaatg aacaagacat caaacctgtt accacagact attttttgat 6420 ggaagaaaaa tattttatat ctaaagaaaa gaatgaatgt aggaaacaac cattccagag 6480 agccattggt ccagaagagg agatcatgca aattttaagc agctggtttc cagaagaggg 6540 atacatgggc aggattgtct taaaaaccca gcaggaaaac ctagaagaga aaaacattgt 6600 tcaagatgac aaagaggtga tcttgagctc agaggaggag agtttctttg tccaagtgca 6660 tgatgtttct ccagagcaac ctcgaacagt catcaaagca ccccgcgtca gcactgcaca 6720 ggatgtcatt cagcagacct tatgcaaagc caaatattcc tacagcatcc tgagcaaccc 6780 caatccaagc gactatgtgc ttttggaaga ggtggtgaaa gacactacca acaagaagac 6840 taccacacca aagtcctctc agcgggtcct tctggatcag gagtgtgtgt ttcaagccca 6900 aagcaagtgg aaaggtgcag gaaaattcat ccttaagcta aaggagcagg tgcaggcatc 6960 tcgagaagat aaaaagaaag gcatttcttt cgcaagtgaa ctcaagaagc tcaccaagtc 7020 aactaaacag ccccgaggac ttacatcacc ttctcagctc ttgacctcag aaagtatcca 7080 aaccaaggaggagaaacctgtgggtggcttgtctccagtgacacaatggattaccgacag7140 tgactaagggcagcatgtttaacccaggtggagatctttaagcaagaagttaaagagtga7200 acatggtggaaaaaatataattattttcatcagacttaaactggaaattgatgatttctg7260 aactgaagccttcacacatgtgagatccatgctgaggagaagcaaaatggcacagggcta7320 gttgccaccaaccaatttactgatgaatgaagcccaggggactgccattttataaatgtc7380 agcagttggaaaaatcgtcacgaattgacttagagcaagggtcagcaagcttgtctgtaa7440 agggccaaacagtaaatattttagggctgggggccataaaatatgttgcaaccacccaat7500 tctgccattgtagtgcaaaagcagccatagacaacacatacatgaacgaacgtggctgta7560 ttccaataaaactttatttatggacactgaaaaaaaaaaaaaaaaaaaa 7609 <210> 43 <211> 1922 <212> DNA
<213> Human <400>

gcacgagaatgtccctgagacccagaagggcctgcgctcagctgctctggcaccccgctg60 cagggatggcctcctgggctaagggcaggagctacctggcgcctggtttgctgcagggcc120 aagtggccatcgtcaccggcggggccacgggcatcggaaaagccatcgtgaaggagctcc180 tggagctggggagtaatgtggtcattgcatcccgtaagttggagagattgaagtctgcgg240 cagatgaactgcaggccaacctacctcccacaaagcaggcacgagtcattcccatacaat300 gcaacatccggaatgaggaggaggtgaataatttggtcaaatctaccttagatacttttg360 gtaagatcaatttcttggtgaacaatggaggaggccagtttctttcccctgctgaacaca420 tcagttctaagggatggcacgctgtgcttgagaccaacctgacgggtaccttctacatgt480 gcaaagcagtttacagctcctggatgaaagagcatggaggatctatcgtcaatatcattg540 tccctactaaagctggatttccattagctgtgcattctggagctgcaagagcaggtgttt600 acaacctcaccaaatctttagctttggaatgggcctgcagtggaatacggatcaattgtg660 ttgcccctggagttatttattcccagactgctgtggagaactatggttcctggggacaaa720 gcttctttgaagggtcttttcagaaaatccccgctaaacgaattggtgttcctgaggagg780 tctcctctgtggtctgcttcctactgtctcctgcagcttccttcatcactggacagtcag840 tggatgtggatgggggccggagtctctatactcactcgtatgaggtaccagatcatgaca900 actggcccaagggagcaggggacctttctgttgtcaaaaagatgaaggagacctttaagg960 agaaagctaagctctgagctgaggaaacaaggtgtcctccatcccccagtgccttcacat1020 cttgaggatatgcttctgtactttttaaaagcttatagttggtatggaaaacatttttct1080 tatttttaagtgttattaattatatctatggaaaaactattcctgaaatatatacagtct1140 tatgtcccaatcagagtcttttaacctatgatttaaaaatgtataagtaacagaaattaa1200 catattttaatgactttactttttatttctaagaaaagtatttgaaaaatggaataattt1260 taaatcaatgataattctagggatcatgaactcccagaagattttattatttaattgtaa1320 aggtagaggccggacgcagtggctcacgcctgtaattccagcactttgggaggccgaggt1380 gggcgggtcagttgaggtcaggagttcaagaccaggctggccaacatggtaaaaccctgt1440 ctctactgaaaaacaacaaaaacaaaaacacaaattagtcgggtgtggtggcacacacct1500 gtagtcccaggtacttgggaggctgaggcaggaggatcgcttgaacccaggaagcagagg1560 ttgcagtgagctgagatcgtgctactgcagtccagcctgggctacagagtgagactgcat1620 ctcaaaaaaaacccmaaaaaacaaaaacaaacaacaacaacaaaattataaaggtagaaa1680 ataaatctaaattgtgtcgtaattaagattattaaaatgagaattatacaatgacttatt1740 tttggtggcaaatactttaggagcaataatgccttatggtaattattgatgtatagtttt1800 ttttgtttatgaagtcaaatttgtataaatttttttaattcaaaggaaaagttttatgtg1860 attttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa1920 as <210> 44 <211> 1182 ' <212> DNA
<213> Human <400> 44 aggacaccag gcacagagat ccaaactatt atatcaaatc caatccctaa aatggaagaa 60 gccaaaagcc aaagtttgga ggaagacttt gaaggacagg ccacacatac aggacccaaa 120 ggagtaataa atgattggag aaagtttaaa ttagagagtc aagacagtga ttcaattcca 180 cctagcaaga aggagattct caggcaaatg tcttctcctc agagtaggaa tggcaaagat 240 tcaaaggaac gagtcagcag aaagatgagc attcaagaat atgaactaat ccataaagag 300 aaagaggatg aaaactgcct tcgtaaatac cgtagacagt gtatgcagga tatgcaccag 360 aagctgagttttgggcctagatatgggtttgtgtatgagctggaaactggaaagcaattc420 ctagaaacaattgaaaaggaactgaagatcaccacaattgttgttcacatttatgaagat480 ggtattaagggttgtgatgctctaaacagtagtttaacatgccttgcagcagaataccct540 atagttaagttttgtaaaataaaagcttcgaatacaggtgctggggaccgcttttcctta600 gatgtacttcctacactgctcatctataaaggtggggaactcataagcaattttattagt660 gttgctgaacagtttgctgaagaattttttgctggggatgtggagtctttcctaaatgaa720 tatgggttactacctgaaagagaggtacatgtcctagagcataccaaaatagaagaagaa780 gatgttgaatgaagattcactatgtcaatatctcatgtttatcctttaggtattggatga840 tggttttggtagtatctatattgcttttgtgaacacagagtatgggcacggctatgctaa900 cttgacaaaaatgactgatgcaacaatcgagttattagcatttcatagtattagttactc960 aaattgatacaatgcttgactacaaaacaaagctgtcttcagcaacattattagtagaca1020 aagaggatgtggataatattatgacatttttcaaaaatccctttcaagttatgttttgtc1080 ttttttactccattttccctcatcactgttattatttggacttttcaaattacattattc1140 attataattttctttgtgtaataaaaatgaaatctcatgaag 1182 <210> 45 <211> 3160 <212> DNA
<213> Human <400> 45 cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 60 ttccgaggcgcccgggctcccggcgcggcggcggagggggcgggcaggccggcgggcggt 120 gatgtggcaggactctttatgcgctgcggcaggatacgcgctcggcgctgggacgcgact 180 gcgctcagttctctcctctcggaagctgcagccatgatggaagtttgagagttgagccgc 240 tgtgaggcgaggccgggctcaggcgagggagatgagagacggcggcggccgcggcccgga 300 gcccctctcagcgcctgtgagcagccgcgggggcagcgccctcggggagccggccggcct 360 gcggcggcggcagcggcggcgtttctcgcctcctcttcgtcttttctaaccgtgcagcct 420 cttcctcggcttctcctgaaagggaaggtggaagccgtgggctcgggcgggagccggctg 480 aggcgcggcggcggcggcggcggcacctcccgctcctggagcgggggggagaagcggcgg 540 cggcggcggccgcggcggctgcagctccagggagggggtctgagtcgcctgtcaccattt 600 ccagggctgggaacgccggagagttggtctctccccttctactgcctccaacacggcggc 660 ggcggcggcg gcacatccag ggacccgggc cggttttaaa cctcccgtcc gccgccgccg 720 caccccccgtggcccgggctccggaggccgccggcggaggcagccgttcggaggattatt780 cgtcttctccccattccgctgccgccgctgccaggcctctggctgctgaggagaagcagg840 cccagtcgctgcaaccatccagcagccgccgcagcagccattacccggctgcggtccaga900 gccaagcggcggcagagcgaggggcatcagctaccgccaagtccagagccatttccatcc960 tgcagaagaagccccgccaccagcagcttctgccatctctctcctcctttttcttcagcc1020 acaggctcccagacatgacagccatcatcaaagagatcgttagcagaaacaaaaggagat1080 atcaagaggatggattcgacttagacttgacctatatttatccaaacattattgctatgg1140 gatttcctgcagaaagacttgaaggcgtatacaggaacaatattgatgatgtagtaaggt1200 ttttggattcaaagcataaaaaccattacaagatatacaatctttgtgctgaaagacatt1260 atgacaccgccaaatttaattgcagagttgcacaatatccttttgaagaccataacccac1320 cacagctagaacttatcaaacccttttgtgaagatcttgaccaatggctaagtgaagatg1380 acaatcatgttgcagcaattcactgtaaagctggaaagggacgaactggtgtaatgatat1440 gtgcatatttattacatcggggcaaatttttaaaggcacaagaggccctagatttctatg1500 gggaagtaaggaccagagacaaaaagggagtaactattcccagtcagaggcgctatgtgt1560 attattatagctacctgttaaagaatcatctggattatagaccagtggcactgttgtttc1620 acaagatgatgtttgaaactattccaatgttcagtggcggaacttgcaatcctcagtttg1680 tggtctgccagctaaaggtgaagatatattcctccaattcaggacccacacgacgggaag1740 acaagttcatgtactttgagttccctcagccgttacctgtgtgtggtgatatcaaagtag1800 agttcttccacaaacagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaa1860 atacattcttcataccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctat1920 gtgatcaagaaatcgatagcatttgcagtatagagcgtgcagataatgacaaggaatatc1980 tagtacttactttaacaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgat2040 acttttctccaaattttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaa2100 atccagaggctagcagttcaacttctgtaacaccagatgttagtgacaatgaacctgatc2160 attatagatattctgacaccactgactctgatccagagaatgaaccttttgatgaagatc2220 agcatacacaaattacaaaagtctgaatttttttttatcaagagggataaaacaccatga2280 aaataaacttgaataaactgaaaatggacctttttttttttaatggcaataggacattgt2340 gtcagattaccagttataggaacaattctcttttcctgaccaatcttgttttaccctata2400 catccacagggttttgacacttgttgtccagttgaaaaaaggttgtgtagctgtgtcatg2460 tatatacctt tttgtgtcaa aaggacattt aaaattcaat taggattaat aaagatggca 2520 ctttcccgtt ttattccagt tttataaaaa gtggagacag actgatgtgt atacgtagga 2580 attttttccttttgtgttctgtcaccaactgaagtggctaaagagctttgtgatatactg2640 gttcacatcctacccctttgcacttgtggcaacagataagtttgcagttggctaagagag2700 gtttccgaaaggttttgctaccattctaatgcatgtattcgggttagggcaatggagggg2760 aatgctcagaaaggaaataattttatgctggactctggaccatataccatctccagctat2820 ttacacacacctttctttagcatgctacagttattaatctggacattcgaggaattggcc2880 gctgtcactgcttgttgtttgcgcatttttttttaaagcatattggtgctagaaaaggca2940 gctaaaggaagtgaatctgtattggggtacaggaatgaaccttctgcaacatcttaagat3000 ccacaaatgaagggatataaaaataatgtcataggtaagaaacacagcaacaatgactta3060 accatataaatgtggaggctatcaacaaagaatgggcttgaaacattataaaaattgaca3120 atgatttattaaatatgttttctcaattgtaaaaaaaaaa 3160 <210> 46 <211> 1224 <212> DNA
<213> Human <400> 46 gggcaggaag acggcgctgc ccggaggagc ggggcgggcg ggcgcgcggg ggagcgggcg 60 gcgggcgggagccaggcccgggcgggggcgggggcggcggggccagaagaggcggcgggc 120 cgcgctccggccggtctgcggcgttggccttggctttggctttggcggcggcggtggaga 180 agatgctgcagtccctggccggcagctcgtgcgtgcgcctggtggagcggcaccgctcgg 240 cctggtgcttcggcttcctggtgctgggctacttgctctacctggtcttcggcgcagtgg 300 tcttctcctcggtggagctgccctatgaggacctgctgcgccaggagctgcgcaagctga 360 agcgacgcttcttggaggagcacgagtgcctgtctgagcagcagctggagcagttcctgg 420 gccgggtgctggaggccagcaactacggcgtgtcggtgctcagcaacgcctcgggcaact 480 ggaactgggacttcacctccgcgctcttcttcgccagcaccgtgctctccaccacaggtt 540 atggccacaccgtgcccttgtcagatggaggtaaggccttctgcatcatctactccgtca 600 ttggcattcccttcaccctcctgttcctgacggctgtggtccagcgcatcaccgtgcacg 660 tcacccgcag gccggtcctc tacttccaca tccgctgggg cttctccaag caggtggtgg 720 ccatcgtcca tgccgtgctc cttgggtttg tcactgtgtc ctgcttcttc ttcatcccgg 780 ccgctgtctt ctcagtcctg gaggatgact ggaacttcct ggaatccttt tatttttgtt 840 ttatttccct gagcaccatt ggcctggggg attatgtgcc tggggaaggc tacaatcaaa 900 aattcagaga gctctataag attgggatca cgtgttacct gctacttggc cttattgcca 960 tgttggtagt tctggaaacc ttctgtgaac tccatgagct gaaaaaattc agaaaaatgt 1020 tctatgtgaa gaaggacaag gacgaggatc aggtgcacat catagagcat gaccaactgt 1080 ccttctcctc gatcacagac caggcagctg gcatgaaaga ggaccagaag caaaatgagc 1140 cttttgtggc cacccagtca tctgcctgcg tggatggccc tgcaaaccat tgagcgtagg 1200 atttgttgca ttatgctaga gcac 1224 <210> 47 <21l> 4465 <212> DNA
<213> Human <400>

caattgtcatacgacttgcagtgagcgtcaggagcacgtccaggaactcctcagcagcgc60 ctccttcagctccacagccagacgccctcagacagcaaagcctacccccgcgccgcgccc120 tgcccgccgctcggatgctcgcccgcgccctgctgctgtgcgcggtcctggcgctcagcc180 atacagcaaatccttgctgttcccacccatgtcaaaaccgaggtgtatgtatgagtgtgg240 gatttgaccagtataagtgcgattgtacccggacaggattctatggagaaaactgctcaa300 caccggaatttttgacaagaataaaattatttctgaaacccactccaaacacagtgcact360 acatacttacccacttcaagggattttggaacgttgtgaataacattcccttccttcgaa420 atgcaattatgagttatgtcttgacatccagatcacatttgattgacagtccaccaactt480 acaatgctgactatggctacaaaagctgggaagccttctctaacctctcctattatacta540 gagcccttcctcctgtgcctgatgattgcccgactcccttgggtgtcaaaggtaaaaagc600 agcttcctgattcaaatgagattgtggaaaaattgcttctaagaagaaagttcatccctg660 atccccagggctcaaacatgatgtttgcattctttgcccagcacttcacgcatcagtttt720 tcaagacagatcataagcgagggccagctttcaccaacgggctgggccatggggtggact780 taaatcatatttacggtgaaactctggctagacagcgtaaactgcgccttttcaaggatg840 gaaaaatgaaatatcagataattgatggagagatgtatcctcccacagtcaaagatactc900 aggcagagatgatctaccctcctcaagtccctgagcatctacggtttgctgtggggcagg960 aggtctttggtctggtgcctggtctgatgatgtatgccacaatctggctgcgggaacaca1020 acagagtatgcgatgtgcttaaacaggagcatcctgaatggggtgatgagcagttgttcc1080 agacaagcaggctaatactgataggagagactattaagattgtgattgaagattatgtgc1140 aacacttgag tggctatcac ttcaaactga aatttgaccc agaactactt ttcaacaaac 1200 aattccagta ccaaaatcgt attgctgctg aatttaacac cctctatcac tggcatcccc 1260 ttctgcctga cacctttcaa attcatgacc agaaatacaa ctatcaacag tttatctaca 1320 acaactctatattgctggaacatggaattacccagtttgttgaatcattcaccaggcaaa1380 ttgctggcagggttgctggtggtaggaatgttccacccgcagtacagaaagtatcacagg1440 cttccattgaccagagcaggcagatgaaataccagtcttttaatgagtaccgcaaacgct1500 ttatgctgaagccctatgaatcatttgaagaacttacaggagaaaaggaaatgtctgcag1560 agttggaagcactctatggtgacatcgatgctgtggagctgtatcctgcccttctggtag1620 aaaagcctcggccagatgccatctttggtgaaaccatggtagaagttggagcaccattct1680 ccttgaaaggacttatgggtaatgttatatgttctcctgcctactggaagccaagcactt1740 ttggtggagaagtgggttttcaaatcatcaacactgcctcaattcagtctctcatctgca1800 ataacgtgaagggctgtccctttacttcattcagtgttccagatccagagctcattaaaa1860 cagtcaccatcaatgcaagttcttcccgctccggactagatgatatcaatcccacagtac1920 tactaaaagaacgttcgactgaactgtagaagtctaatgatcatatttatttatttatat1980 gaaccatgtctattaatttaattatttaataatatttatattaaactccttatgttactt2040 aacatcttctgtaacagaagtcagtactcctgttgcggagaaaggagtcatacttgtgaa2100 gacttttatgtcactactctaaagattttgctgttgctgttaagtttggaaaacagtttt2160 tattctgttttataaaccagagagaaatgagttttgacgtctttttacttgaatttcaac2220 ttatattataagaacgaaagtaaagatgtttgaatacttaaacactatcacaagatggca2280 aaatgctgaaagtttttacactgtcgatgtttccaatgcatcttccatgatgcattagaa2340 gtaactaatgtttgaaattttaaagtacttttggttatttttctgtcatcaaacaaaaac2400 aggtatcagtgcattattaaatgaatatttaaattagacattaccagtaatttcatgtct2460 actttttaaaatcagcaatgaaacaataatttgaaatttctaaattcatagggtagaatc2520 acctgtaaaagcttgtttgatttcttaaagttattaaacttgtacatataccaaaaagaa2580 gctgtcttggatttaaatctgtaaaatcagatgaaattttactacaattgcttgttaaaa2640 tattttataagtgatgttcctttttcaccaagagtataaacctttttagtgtgactgtta2700 aaacttccttttaaatcaaaatgccaaatttattaaggtggtggagccactgcagtgtta2760 tctcaaaataagaatattttgttgagatattccagaatttgtttatatggctggtaacat2820 gtaaaatcta tatcagcaaa agggtctacc tttaaaataa gcaataacaa agaagaaaac 2880 caaattattg ttcaaattta ggtttaaact tttgaagcaa actttttttt atccttgtgc 2940 actgcaggcctggtactcagattttgctatgaggttaatgaagtaccaagctgtgcttga3000 ataacgatatgttttctcagattttctgttgtacagtttaatttagcagtccatatcaca3060 ttgcaaaagtagcaatgacctcataaaatacctcttcaaaatgcttaaattcatttcaca3120 cattaattttatctcagtcttgaagccaattcagtaggtgcattggaatcaagcctggct3180 acctgcatgctgttccttttcttttcttcttttagccattttgctaagagacacagtctt3240 ctcatcacttcgtttctcctattttgttttactagttttaagatcagagttcactttctt3300 tggactctgcctatattttcttacctgaacttttgcaagttttcaggtaaacctcagctc3360 aggactgctatttagctcctcttaagaagattaaaagagaaaaaaaaaggcccttttaaa3420 aatagtatacacttattttaagtgaaaagcagagaattttatttatagctaattttagct3480 atctgtaaccaagatggatgcaaagaggctagtgcctcagagagaactgtacggggtttg3540 tgactggaaaaagttacgttcccattctaattaatgccctttcttatttaaaaacaaaac3600 caaatgatat ctaagtagtt ctcagcaata ataataatga cgataatact tcttttccac 3660 atctcattgtcactgacatttaatggtactgtatattacttaatttattgaagattatta3720 'tttatgtcttattaggacactatggttataaactgtgtttaagcctacaatcattgattt3780 ttttttgttatgtcacaatcagtatattttctttggggttacctctctgaatattatgta3840 aacaatccaaagaaatgattgtattaagatttgtgaataaatttttagaaatctgattgg3900 catattgagatatttaaggttgaatgtttgtccttaggataggcctatgtgctagcccac3960 aaagaatattgtctcattagcctgaatgtgccataagactgaccttttaaaatgttttga4020 gggatctgtggatgcttcgttaatttgttcagccacaatttattgagaaaatattctgtg4080 tcaagcactgtgggttttaatatttttaaatcaaacgctgattacagataatagtattta4140 tataaataattgaaaaaaattttcttttgggaagagggagaaaatgaaataaatatcatt4200 aaagataactcaggagaatcttctttacaattttacgtttagaatgtttaaggttaagaa4260 agaaatagtcaatatgcttgtataaaacactgttcactgttttttttaaaaaaaaaactt4320 gatttgttattaacattgatctgctgacaa.aacctgggaatttgggttgtgtatgcgaat4380 gtttcagtgcctcagacaaatgtgtatttaacttatgtaaaagataagtctggaaataaa4440 tgtctgtttatttttgtactattta 4465 <210> 48 <211> 631 <212> DNA
<213> Human <400>

caatacagctaaggaattatcccttgtaaataccacagacccgccctggagccaggccaa 60 gctggactgcataaagattggtatggccttagctcttagccaaacaccttcctgacacca 120 tgagggccagcagcttcttgatcgtggtggtgttcctcatcgctgggacgctggttctag 180 aggcagctgtcacgggagttcctgttaaaggtcaagacactgtcaaaggccgtgttccat 240 tcaatggacaagatcccgttaaaggacaagtttcagttaaaggtcaagataaagtcaaag 300 cgcaagagccagtcaaaggtccagtctccactaagcctggctcctgccccattatcttga 360 tccggtgcgccatgttgaatccccctaaccgctgcttgaaagatactgactgcccaggaa 420 tcaagaagtgctgtgaaggctcttgcgggatggcctgtttcgttccccagtgaagggagc 480 cggtccttgctgcacctgtgccgtccccagagctacaggccccatctggtcctaagtccc 540 tgctgcccttccccttcccacactgtccattcttcctcccattcaggatgcccacggctg 600 gagctgcctctctcatccactttccaataaa 631 <210> 49 <211> 701 <2l2> DNA
<2l3> Human <220>
<221> misc_feature <222> (464)..(464) <223> n is a, c, g, 0r t <400>

tttttttttcgcataaatattgcttttattacaagaaagaagagaccacctctgaagtaa 60 ggcacaacacaattccattgtcactgtggcagaagtccctgttgctcatccctttgatct 120 cagccaagactgtggtccacgggcctaaggcacttgagcttttccctcaactgaagtgta 180 gggggtgcctgagagctgagcctcgtgggagtgtccatggtctctggacctgcatcgaag 240 ttcatgtgtttccactggtgctgaagatgaacatcaagaattactagacatgtaaaagtg 300 tctttaagtgtctttcctcctgagtccacctttggcaatggtccccaaagcctggcccct 360 tagagatgcagctccagatcctggccaccctcagggttcaaagagactggcccaggggta 420 cacaattgctggaatattctctgcgagtcatgcacacgtgcggnggtgaggtgcagttat 480 atggtgacacacacagtgttactgtgagctctcagggtgcacagagggcaggtgacaagg 540 gcatcagctaatctgtcccacctggtccagcccatccagttcaggggcatcaagggggct 600 gaggccccggtagccactgtagaccctgtgactatcactgacacegtcactgggctccat 660 tgggcaaatgtagtccgcgattcatcgaacttcttttttct 701 <210> 50 <211> 602 <212> DNA
<2l3> Human <400>

atttagaaatgtaaacatttatttaaaagtaggtagcaagttaaaaatgaatacttgcct 60 gaaatcataaaacataatcaagttctttttaaaacagttaatttttttcctataatttac 120 tttcatcgaaagtatattatctttgtttaacatgctagatagaagcaatttagcaacata 180 aaatatattagctatagtatgttcaaaagaatgagaaatataaattcagagatgagacca 240 tcattttttgcagttaaaaaaaaatgttgattctggtgcaacatacactgattatccagg 300 ttttacattttagggctgaaaccctgaggaacctgctggtgactgtttagcactgagcag 360 agttcagtgtgcatgcgcttccagagttaaaagctaaagcagactgagaaacaaaaaacc 420 aacatctttgcatttctgagttttcacttgtaatcataggttttcccaaattattagaat 480 gtctataccttagctgttttactagaatgatttatgctagtatagtcacttgtttagaag 540 tcggaaaaagatcattttttctttttagaaattactaagctctgttgtactacagctgat 600 cc 602 <210> 51 <211> 1653 <212> DNA
<213> Human <400>

acgtccggggaggggccaggtgagcggcagacccggcacgcaggtgggggccggcggggt 60 ccgtggccagagctgcagagagacaaggcggcggcggctgctgtgctgggtgcagtgagg 120 aagaggccctcggtggtgcccatggctggccaggatcctgcgctgagcacgagtcacccg 180 ttctacgacgtggccagacatggcattctgcaggtggcaggggatgaccgctttggaaga 240 cgtgttgtcacgttcagctgctgccggatgccgccctcccacgagctggaccaccagcgg 300 ctgctggagtatttgaagtacacactggaccaatacgttgagaacgattataccatcgtc 360 tatttccactacgggctgaacagccggaacaagccttccctgggctggctccagagcgca 420 tacaaggagttcgataggaaagacggggatctcactatgtggcccaggctggtctcgaac 480 tccaagctcaagcgatcctcccacctcagcctcccaaagtactgggattacaggtacaag 540 aagaacttgaaggccctctacgtggtgcaccccaccagcttcatcaaggtcctgtggaac 600 atcttgaagcccctcatcagtcacaagtttgggaagaaagtcatctatttcaactacctg 660 agtgagctcc acgaacacct taaatacgac cagctggtca tccctcccga agttttgcgg 720 tacgatgaga agctccagag cctgcacgag ggccggacgc cgcctcctac caagacacca 780 ccgccgcggc ccccgctgcc cacacagcag tttggcgtca gtctgcaata cctcaaagac 840 aaaaatcaag gcgaactcat cccccctgtg ctgaggttca cagtgacgta cctgagagag 900 aaaggcctgcgcaccgagggcctgttccggagatccgccagcgtgcagaccgtccgcgag960 atccagaggctctacaaccaagggaagcccgtgaactttgacgactacggggacattcac1020 atccctgccgtgatcctgaagaccttcctgcgagagctgccccagccgcttctgaccttc1080 caggcctacgagcagattctcgggatcacctgtgtggagagcagcctgcgtgtcactggc1140 tgccgccagatcttacggagcctcccagagcacaactacgtcgtcctccgctacctcatg1200 ggctttctgcatgcggtgtcccgggagagcatcttcaacaaaatgaacagctctaacctg1260 gcctgtgtcttcgggctgaatttgatctggccatcccagggggtctcctccctgagtgcc1320 cttgtgcccctgaacatgttcactgaactgctgatcgagtactatgaaaagatcttcagc1380 accccggaggcacctggggagcacggcctggcaccatgggaacaggggag cagggcagcc1440 cctttgcaggaggctgtgccacggacacaagccacgggcctcaccaagcc taccctacct1500 ccgagtcccctgatggcagccagaagacgtctctagtgttgcgaacactc tgtatgtttc1560 gagctacctcccacacctgtctgtgcacttgtatgttttgtaaacttggc atctgtaaaa1620 ataaccagccattagatgaattcagaaccttct 1653 <210> 52 <211> 846 <212> DNA
<213> Human <400>

gtataaggtccacaccccgggagctgagtgattgcagaaactggccttccatctctctca 60 gacaccaagctgcagatccaggcttttctgggaaagtgaggccaccatggctctggagaa 120 gtctcttgtccggctccttctgcttgtcctgatactgctggtgctgggctgggtccagcc 180 ttccctgggcaaggaatcccgggccaagaaattccagcggcagcatatggactcagacag 240 ttcccccagcagcagctccacctactgtaaccaaatgatgaggcgccggaatatgacaca 300 ggggcggtgcaaaccagtgaacacctttgtgcacgagcccctggtagatgtccagaatgt 360 ctgtttccaggaaaaggtcacctgcaagaacgggcagggcaactgctacaagagcaactc 420 cagcatgcacatcacagactgccgcctgacaaacggctccaggtaccccaactgtgcata 480 ccggaccagc ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc 540 agtccacttt gatgcttctg tggaggactc tacctaaggt cagagcagcg agatacccca 600 cctccctcaacctcatcctctccacagctgcctcttccctcttccttccctgctgtgaaa660 gaagtaactacagttagggctcctattcaacacacacatgcttccctttcctgagtccca720 tccctgcgtgattttgggggtgaagagtgggttgtgaggtgggccccatgttaacccctc780 cactctttctttcaataaaacgcagttgcaaacaataaaaaaaaaaaaaaaaaaaaaaaa840 aaaaaa 846 <210> 53 <2l1> 2566 <212> DNA
<213> Human <400> 53 ggcacgagtt gtgctcctcg cttgcctgtt ccttttccac gcattttcca ggataactgt 60 gactccaggcccgcaatggatgccctgcaactagcaaattcggcttttgccgttgatctg120 ttcaaacaactatgtgaaaaggagccactgggcaatgtcctcttctctccaatctgtctc180 tccacctctctgtcacttgctcaagtgggtgctaaaggtgacactgcaaatgaaattgga240 caggttcttcattttgaaaatgtcaaagatataccctttggatttcaaacagtaacatcg300 gatgtaaacaaacttagttccttttactcactgaaactaatcaagcggctctacgtagac360 aaatctctgaatctttctacagagttcatcagctctacgaagagaccctatgcaaaggaa420 ttggaaactgttgacttcaaagataaattggaagaaacgaaaggtcagatcaacaactca480 attaaggatctcacagatggccactttgagaacattttagctgacaacagtgtgaacgac540 cagaccaaaatccttgtggttaatgctgcctactttgttggcaagtggatgaagaaattt600 cctgaatcagaaacaaaagaatgtcctttcagactcaacaagacagacaccaaaccagtg660 cagatgatgaacatggaggccacgttctgtatgggaaacattgacagtatcaattgtaag720 atcatagagcttccttttcaaaataagcatctcagcatgttcatcctactacccaaggat780 gtggaggatgagtccacaggcttggagaagattgaaaaacaactcaactcagagtcactg840 tcacagtggactaatcccagcaccatggccaatgccaaggtcaaactctccattccaaaa900 tttaaggtggaaaagatgattgatcccaaggcttgtctggaaaatctagggctgaaacat960 atcttcagtgaagacacatctgatttctctggaatgtcagagaccaagggagtggcccta1020 tcaaatgttatccacaaagtgtgcttagaaataactgaagatggtggggattccatagag1080 gtgccaggagcacggatcctgcagcacaaggatgaattgaatgctgaccatccctttatt1140 tacatcatcaggcacaacaaaactcgaaacatcattttctttggcaaattctgttctcct1200 taagtggcatagcccatgttaagtcctccctgacttttctgtggatgccgatttctgtaa1260 actctgcatccagagattcattttctagatacaataaattgctaatgttgctggatcagg1320 aagccgccagtacttgtcatatgtagccttcacacagatagacctttttttttttccaat1380 tctatcttttgtttccttttttcccataagacaatgacatacgcttttaatgaaaaggaa1440 tcacgttagaggaaaaatatttattcattatttgtcaaattgtccggggtagttggcaga1500 aatacagtcttccacaaagaaaattcctataaggaagatttggaagctcttcttcccagc1560 actatgctttccttctttgggatagagaatgttccagacattctcgcttccctgaaagac1620 tgaagaaagtgtagtgcatgggacccacgaaactgccctggctccagtgaaacttgggca1680 catgctcaggctactataggtccagaagtccttatgttaagccctggcaggcaggtgttt1740 attaaaattctgaattttggggattttcaaaagataatattttacatacactgtatgtta1800 tagaacttcatggatcagatctggggcagcaacctataaatcaacaccttaatatgctgc1860 aacaaaatgtagaatattcagacaaaatggatacataaagactaagtagcccataagggg1920 tcaaaatttgctgccaaatgcgtatgccaccaacttacaaaaacacttcgttcgcagagc1980 ttttcagattgtggaatgttggataaggaattatagacctctagtagctgaaatgcaaga2040 ccccaagaggaagttcagatcttaatataaattcactttcatttttgatagctgtcccat2100 ctggtcatgtggttggcactagactggtggcaggggcttctagctgactcgcacagggat2160 tctcacaatagccgatatcagaatttgtgttgaaggaacttgtctcttcatctaatatga2220 tagcgggaaaaggagaggaaactactgcctttagaaaatataagtaaagtgattaaagtg2280 ctcacgttaccttgacacatagtttttcagtctatgggtttagttactttagatggcaag2340 catgtaacttatattaatagtaatttgtaaagttgggtggataagctatccctgttgccg2400 gttcatggattacttctctataaaaaatatatatttaccaaaaaattttgtgacattcct2460 tctcccatctcttccttgacatgcattgtaaataggttcttcttgttctgagattcaata2520 ttgaatttctcctatgctattgacaataaaatattattgaactacc 2566 <210> 54 <211> 555 <212> DNA
<213> Human <220>
<221> misc_feature <222> (9). (10) <223> n is a, c, g, or t <400> 54 tttttattnn ttcagttctg ggtctataga aacccagggg gattttcatt tgctacaaca 60 gattcccttctaataaaatgcactggcaaggtgaccagtgagtgacccaatgtctggttg 120 ggaaatctctctctgaacttcttgctgttggacctaaaatgtggatgtaaattggatcac 180 agctggtttggcattgaaaaaaatacatacacaacaaacaattacaacttctttatatgg 240 cagtttttactgggtgtctaatactctctttactgtctcaagtggaagtccaaacaaatt 300 tcatttttgtagtaaaaaatctttatttccaaaatgatttgttagccaaaagaactataa 360 accacctaacaagactttggtaagaaagagacttgatgcttcttataaattccccattgc 420 aaacaaaaaataacaatccaacaagagtcatgttacccattcttagccattaacctggtt 480 ttaagtctccaaaatcaggattttaaaatgtacccaactgggaccaaatacaaacatgag 540 acactagggtggctt 555 <210> 55 <211> 1984 <212> DNA
<213> Human <400>

ggatccagagatttagattttttataagctttcctgccaccgaaacgggtgtttgggacc 60 tcacgaggccctgttcattcttcgtcgctgcgctccccactctgtactggatgcatttac 120 tgacgttgttgtctccgtccccagagtatgaacccccaaggtgactcatgcagctgtggg 180 tgcccggcatacagcatggtgactggaatggatgagcacccaataaacatttgttgcagg 240 aatgcaggaggacgggcaggccagcaagcaggctgcctggtttttcccacatgggctttt 300 ctgggaaagaagagcttctatttttggaaagggctgctatgattgagaaaagttcatggc 360 agcaaaaaaaggacagacgtcgggagggaaacactcctagttctcccagacaacacattt 420 tttaaaaagactccttcatctctttaataataacggtaacgacaatgacaatgatgatta 480 cttatgagtgcggctagtgccagccactgtgttgtcactgggcgagtaatgatctcattg 540 gatcttcacggtgggcgtgcggggctccagggacagcctgcgttcctgggctggctgggt 6,00 gcagctctcttttcaggagagaaagctctcttggaggagctggaaaggtgcccgactcca 660 gccatgctggcgctactgtgttcctgcctgctcctggcagccggtgcctcggacgcctgg 720 acgggcgaggactcggcggagcccaactctgactcggcggagtggatccgagacatgtac 780 gccaaggtcacggagatctggcaggaggtcatgcagcggcgggacgacgacggcacgctc 840 cacgccgcctgccaggtgcagccgtcggccacgctggacgccgcgcagccccgggtgacc 900 ggcgtcgtcctcttccggcagcttgcgccccgcgccaagctcgacgccttcttcgccctg 960 gagggcttcccgaccgagccgaacagctccagccgcgccatccacgtgcaccagttcggg1020 gacctgagccagggctgcgagtccaccgggccccactacaacccgctggccgtgccgcac1080 ccgcagcacccgggcgacttcggcaacttcgcggtccgcgacggcagcctctggaggtac1140 cgcgccggcctggccgcctcgctcgcgggcccgcactccatcgtgggccgggccgtggtc1200 gtccacgctggcgaggacgacctgggccgcggcggcaaccaggccagcgtggagaacggg1260 aacgcgggccggcggctggcetgctgcgtggtgggcgtgtgcgggcccgggctctgggag1320 cgccaggcgcgggagcactcagagcgcaagaagcggcggcgcgagagcgagtgcaaggcc1380 gcctgagcgcggcccccacccggcggcggccagggacccccgaggcccccctctgccttt1440 gagcttctcctctgctccaacagacaccttccactctgaggtctcaccttcgcctctgct1500 gaagtctccccgcagccctctccacccagaggtctccctataccgagacccaccatcctt1560 ccatcctgaggaccgccccaaccctcggagccccccactcagtaggtctgaaggcctcca1620 tttgtaccgaaacaccccgctcacgctgacagcctcctaggctccctgaggtacctttcc1680 acccagaccctccttccccaccccataagccctgagactcccgcctttgacctgacgatc1740 ttcccccttcccgccttcaggttcctcctaggcgctcagaggccgctctg'gggggttgcc1800 tcgagtccccccacccctccccacccaccaccgctcccgcggcaagccagcccgtgcaac1860 ggaagccaggccaactgccccgcgtcttcagctgtttcgcatccaccgccaccccactga1920 gagctgctcctttgggggaatgtttggcaacctttgtgttacagattaaaaattcagcaa1980 ttca 1984 <210> 56 <211> 1621 <212> DNA
<213> Human <400>

ggcacgaggggacagctcctgcctcccgcagggcccacctgtgtcccccagcgccgctcc60 acccagcaggcctgagcccctctctgctgccagacaccccctgctgcccactctcctgct120 gctcgggttctgaggcacagcttgtcacaccgaggcggattctctttctctttctctttc180 tcttctggcccacagccgcagcaatggcgctgagttcctctgctggagttcatcctgcta240 gctgggttcccgagctgccggtctgagcctgaggcatggagcctcctggagactgggggc300 ctcctccctggagatccacccccagaaccgacgtcttgaggctggtgctgtatctcacct360 tcctgggagc cccctgctac gccccagctc tgccgtcctg caaggaggac gagtacccag 420 tgggctccga gtgctgcccc aagtgcagtc caggttatcg tgtgaaggag gcctgcgggg 480 agctgacgggcacagtgtgtgaaccctgccctccaggcacctacattgcccacctcaatg540 gcctaagcaagtgtctgcagtgccaaatgtgtgacccagccatgggcctgcgcgcgagcc600 ggaactgctccaggacagagaacgccgtgtgtggctgcagcccaggccacttctgcatcg660 tccaggacggggaccactgcgccgcgtgccgcgcttacgccacctccagcccgggccaga720 gggtgcagaagggaggcaccgagagtcaggacaccctgtgtcagaactgccccccgggga780 ccttctctcccaatgggaccctggaggaatgtcagcaccagaccaagtgcagctggctgg840 tgacgaaggccggagctgggaccagcagctcccactgggtatggtggtttctctcaggga900 gcctcgtcatcgtcattgtttgctccacagttggcctaatcatatgtgtgaaaagaagaa960 agccaaggggtgatgtagtcaaggtgatcgtctccgtccagcggaaaagacaggaggcag1020 aaggtgaggccacagtcattgaggccctgcaggcccctccggacgtcaccacggtggccg1080 tggaggagacaataccctcattcacggggaggagcccaaaccactgacccacagactctg1140 caccccgacgccagagatacctggagcgacggctgctgaaagaggctgtccacctggcga1200 aaccaccggagcccggaggcttgggggctccgccctgggctggcttccgtctcctccagt1260 ggagggagaggtggggcccctgctggggtagagctggggacgccacgtgccattcccatg1320 ggccagtgagggcctggggcctctgttctgctgtggcctgagctccccagagtcctgagg1380 aggagcgccagttgcccctcgctcacagaccacacacccagccctcctgggccagcccag1440 agggcccttcagaccccagctgtctgcgcgtctgactcttgtggcctcagcaggacaggc1500 cccgggcactgcctcacagccaaggctggactgggttggctgcagtgtggtgtttagtgg1560 ataccacatcggaagtgattttctaaattggatttgaattcggaaaaaaaaaaaaaaaaa1620 a 1621 <210> 57 <211> 2755 <212> DNA
<213> Human <400>

cctacccgcgcgcaggccaagttgctgaatcaatggagccctccccaacccgggcgttcc60 ccagcgaggcttccttcccatcctcctgaccaccggggcttttcgtgagctcgtctctga120 tctcgcgcaagagtgacacacaggtgttcaaagacgcttctggggagtgagggaagcggt180 ttacgagtgacttggctggagcctcaggggcgggcactggcacggaacacaccctgaggc240 cagccctggctgcccaggcggagctgcctcttctcccgcgggttggtggacccgctcagt300 acggagttggggaagctctttcacttcggaggattgctcaacaaccatgctgggcatctg360 gaccctcctacctctggttcttacgtctgttgctagattatcgtccaaaagtgttaatgc420 ccaagtgactgacatcaactccaagggattggaattgaggaagactgttactacagttga480 gactcagaacttggaaggcctgcatcatgatggccaattctgccataagccctgtcctcc540 aggtgaaaggaaagctagggactgcacagtcaatggggatgaaccagactgcgtgccctg600 ccaagaagggaaggagtacacagacaaagcccatttttcttccaaatgcagaagatgtag660 attgtgtgatgaaggacatggcttagaagtggaaataaactgcacccggacccagaatac720 caagtgcagatgtaaaccaaactttttttgtaactctactgtatgtgaacactgtgaccc780 ttgcaccaaatgtgaacatggaatcatcaaggaatgcacactcaccagcaacaccaagtg840 caaagaggaaggatccagatctaacttggggtggctttgtcttcttcttttgccaattcc900 actaattgtttgggtgaagagaaaggaagtacagaaaacatgcagaaagcacagaaagga960 aaaccaaggttctcatgaatctccaaccttaaatcctgaaacagtggcaataaatttatc1020 tgatgttgacttgagtaaatatatcaccactattgctggagtcatgacactaagtcaagt1080 taaaggctttgttcgaaagaatggtgtcaatgaagccaaaatagatgagatcaagaatga1140 caatgtccaagacacagcagaacagaaagttcaactgcttcgtaattggcatcaacttca1200 tggaaagaaagaagcgtatgacacattgattaaagatctcaaaaaagccaatctttgtac1260 tcttgcagagaaaattcagactatcatcctcaaggacattactagtgactcagaaaattc1320 aaacttcagaaatgaaatccaaagcttggtctagagtgaaaaacaacaaattcagttctg1380 agtatatgcaattagtgtttgaaaagattcttaatagctggctgtaaatactgcttggtt1440 ttttactgggtacattttatcatttattagcgctgaagagccaacatatttgtagatttt1500 taatatctcatgattctgcctccaaggatgtttaaaatctagttgggaaaacaaacttca1560 tcaagagtaaatgcagtggcatgctaagtacccaaataggagtgtatgcagaggatgaaa1620 gattaagattatgctctggcatctaacatatgattctgtagtatgaatgtaatcagtgta1680 tgttagtacaaatgtctatccacaggctaaccccactctatgaatcaatagaagaagcta1740 tgaccttttgctgaaatatcagttactgaacaggcaggccactttgcctctaaattacct1800 ctgataattctagagattttaccatatttctaaactttgtttataactctgagaagatca1860 tatttatgtaaagtatatgtatttgagtgcagaatttaaataaggctctacctcaaagac1920 ctttgcacagtttattggtgtcatattatacaatatttcaattgtgaattcacatagaaa1980 acattaaattataatgtttgactattatatatgtgtatgcattttactggctcaaaacta2040 cctacttctttctcaggcatcaaaagcattttgagcaggagagtattactagagctttgc2100 cacctctccatttttgccttggtgctcatcttaatggcctaatgcacccccaaacatgga2160 aatatcaccaaaaaatacttaatagtccaccaaaaggcaagactgcccttagaaattcta2220 gcctggtttggagatactaactgctctcagagaaagtagctttgtgacatgtcatgaacc2280 catgtttgcaatcaaagatgataaaatagattcttatttttcccccacccccgaaaatgt2340 tcaataatgtcccatgtaaaacctgctacaaatggcagcttatacatagcaatggtaaaa2400 tcatcatctggatttaggaattgctcttgtcatacccccaagtttctaagatttaagatt2460 ctccttactactatcctacgtttaaatatctttgaaagtttgtattaaatgtgaatttta2520 agaaataatatttatatttctgtaaatgtaaactgtgaagatagttataaactgaagcag2580 atacctggaaccacctaaagaacttccatttatggaggatttttttgccccttgtgtttg2640 gaattataaaatataggtaaaagtacgtaattaaataatgtttttggtaaaaaaaaaaaa2700 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 2755 <210> 58 <211> 2553 <212> DNA
<213> Human <400>

ctaaaggccttgcacaacatcagagagttcatactggagagaaccttacacatttcacga60 gtatggaaagacctttgctcaaaattcagcccttgtaatgcataaggcaattcatactgg120 aaagaaaccttacacatgtaatgaatgtggcaaggtttttagtagaaaagcacaccttgc180 atgtcatcatagacttcatactgtctaaggtttctaatcaacaatcaaaccttgcacaac240 atcagagagtttatactggagagaaaccttacaagtgtaatgagtggggcaaagccttaa300 gtgggaagtcgtcacttttttatcatcaagcaatccatggtgtagggaaactttgcaaat360 gtaatgattgtcacaaagtcttcagtaatgctacaaccattgcaaatcactggagaatcc420 ataatgaagacagatcttacaagtgtaataaatgtggtaaaattttcagacatcgatcat480 atcttgcagtttatcagcgaactcatactggagagaaaccttacaaatatcatgactgtg540 gcaaggtcttcagtcaagcttcatcctatgcaaaacataggagaattcatacaggagaga600 aacctcacaagtgtgatgattgtggcaaagtcttgacttcacgttcacacctcattagac660 atcagagaatccatactggacagaaatcttacaaatgtcttaagtgtggcaaggtcttca720 gtctgtgggcactccatgcagaacatcagaaaattcatttttgagataactgttccaaat780 acagtgactatagaagatcataaagctttaattgacattagagccaaataggcattgact840 tgagattgagttgacttaaccttgagtttaagaattaatttacattaaagtgtttatgtt900 aagaagattgggccaggtgggattacaggcgcgagcaccgcgcccggcccctaagttaat960 atttcaaacaatcgaaggtaaaacaacatattgtgttgggccacctgtactgaacgctga1020 atcgtttttcctcttaagttgaaaatggttttaatgcaaagcgcctttttttgagcaggt1080 agagtcacgcatccggcaggcggggcgagctcccctctgtctggggcagggtgggggaga1140 ggggcagggacctcggtaaaggggtggagtggcgcgctggttgccgcgggcactggcaat1200 tagaagggattattaaactaagcaaggtcctgggttgtttgagtggataatggaaactga1260 aaggtgacgtgcaaaactgcctattactcccaggagtggaggataatttcatatttcatg1320 gaaataaactcagggcccggagcggtggctcacacctgtaatcccagcactttgagaggc1380 caaggagggaggatcgcttaagcccaggaattcgaaatcagcctaggcaacatagtaaga1440 cctcatctctactaaaaataaaaaaaaacagccaggtgtgttagtccacacctgtggtcc1500 cagctgcctcagcttcccgagtagctgggattacaggtatgaaccactatgcccggctaa1560 ctttgttttttttttttagaaattaaaccttttttcagcttaatgacccaggggtgtatt1620 tttgaaggacttgggagctctctttgaaaggcaaacaacaagggaaacagtacctttatc1680 tcagtaggaaattaaataattcaaacatcaaataacttcaatttaaggctatggactttg1740 agataattctgagccttgagaggaatgtggtcaggcaacctgagtccagtggaatgcagg1800 tgcaacttctaagagttttcctgtaagtaattaagaagactaagtagccccagagataag1860 acctcctcggatcattgtcccttcttatgtagtgataaagtaaccttccttgaagtgtat1920 ctatccgtaatcaatcaagttgctgcagcctatgcactggcccagaataaaaaacgtggt1980 gattctgctaaagcttctctgtctttccctgtgtgtgaaatcttaacgtctctacttggg2040 aacgctgatcccattcatttagagttgatgtttccacgtggctatttccaagctttgcct2100 tcaaataaattctgtacttaatcatatattctaaattttattatttactgctgacatcag2160 tttctgtcggattgtaggagcctcaccagagagggcccctgtcgccatgttgtaaaactc2220 acacttgccaaaagttgtgggttagggtttctccccctccctcaggatgacgctagttag2280 ctgacacagatggtcacctccattaccaagtagagtcaggatgaactatgtgtgactgtt2340 caactatgtgtcctcttccctgaggactgattagtgtttatcttgaaaacatgtccttaa2400 tgggttgtatagaacactgaagcatctgatttcaaactcttagctcttttcctctatttc2460 ccatcacattctggtctaaggcttatttattaataaaatgatttttatttctttaaacaa2520 aaaaaactttagagcacactggggtaccggatc 2553 <210> 59 <211> 452 < 212 > DI~iA

<213>
Human <400>

gcggccgcgttgatccacagggcgctgttcagaaagcccaggaaagcaaagagccagtga60 agcctggggggctggctgtcagatgtggcaaaaaaggtcactgaagccaaggctgtgcct120 gcgatcaccaccacgacccagacgggaacgaggccgcctatctcatagacaccataggtc180 cccgactgcagggtcaggaccacaaccagggggctgataaccagatgcagacagttgagg240 ggccgtttccagttctggtcatccttgtccgggtccacgacggggactgtgaggagcagc300 aggaactccacaggcagcttgaacaccttgagggctttccagtatgctgatttccttctc360 cacttcatgtaatccaggggattgagggcccggaccaggatctgagccgtggtctcctgg420 tagaagaacagcggccggtactcatcaccgto 452 <210> 60 <211> 1130 <2l2> DNA
<213> Human <400>

ggcccttagagtcttggttgccaaacagatttgcagatcaaggagaacccaggagtttca60 aagaagcgctagtaaggtctctgagatccttgcactagctacatcctcagggtaggagga120 agatggcttccagaagcatgcggctgctcctattgctgagctgcctggccaaaacaggag180 tcctgggtgatatcatcatgagacccagctgtgctcctggatggttttaccacaagtcca240 attgctatggttacttcaggaagctgaggaactggtctgatgccgagctcgagtgtcagt300 cttacggaaacggagcccacctggcatctatcctgagtttaaaggaagccagcaccatag360 cagagtacataagtggctatcagagaagccagccgatatggattggcctgcacgacccac420 agaagaggcagcagtggcagtggattgatggggccatgtatctgtacagatcctggtctg480 gcaagtccatgggtgggaacaagcactgtgctgagatgagctccaataacaactttttaa540 cttggagcag caacgaatgc aacaagcgcc aacacttcct gtgcaagtac cgaccataga 600 gcaagaatca agattctgct aactcctgca cagccccgtc ctcttccttt ctgctagcct 660 ggctaaatctgctcattatttcagaggggaaacctagcaaactaagagtgataagggccc720 tactacactggcttttttaggcttagagacagaaactttagcattggcccagtagtggct780 tctagctctaaatgtttgccccgccatccctttccacagtatccttcttccctcctcccc840 tgtctctggctgtctcgagcagtctagaagagtgcatctccagcctatgaaacagctggg900 tctttggccataagaagtaaagatttgaagacagaaggaagaaactcaggagtaagcttc960 tagaccccttcagcttctacacccttctgccctctctccattgcctgcaccccaccccag1020 ccactcaact cctgcttgtt tttcctttgg ccataggaag gtttaccagt agaatccttg 1080 ctaggttgat gtgggccata cattccttta ataaaccatt gtgtacataa 1130 <210> 61 <211> 3323 <212> DNA
<213> Human <400>

tgcttcataaaatttacctaagcaagtggtcttgcttgcctcaaatccaagcagtcttga60 acacttggaggcaattaatgagtatatcttagtcaaaagaattgttggagctttttatta120 aagctgcagtttcagttctgcttttggggaattgtgctatgaaagcagctgccaaaataa180 gctcatttattttcttcaatcccactcagtgctcagtcactatattctgtttcctttttt240 tttttcaagttgcatatttggtttccccttatgattgggaaagatgaattttcagcagaa300 aacagtgtttgttcactttcaaagagtgatagtttctaaaacatttagagcaataaatat360 tcatcagaggtaccaagtaagccagcagaagagttaagggttagagaaatcccttatttc420 atgtcttgactctaaaatgatcaaagtacttttccttgtaatgtggatttcttcttatgc480 ggatatgcaaaaacttcagttatacgtagtaatgctagcaggtaattttagtggacattt540 tataacaactgtcactttgttttgccacatgtagagtttgttcagctattttccagatat600 ctccccacaaaaggaggcaaagggtaccagcttttcaatgagcattacctattacttggc660 aaagatgatgaagactctattaatagttcatttgataaatgttgacataaccaacaatag720 agattaggaagttagttttaagaaatcaatagcatatagacattaccctcatggagtttg780 tattctactacttgaactgattgtagctataaaagcatagttagatagctgaatagttag840 atcataagcaaagaaggccagaacacatctcttatcaagaaatcaatgaatagtttatct900 catttttaaagcaactttatccttctttaattccttcctttcttctagtgcaaaactact960 taataaggttggtgtttaggttagtgttcacaccattcctcatctggtgtgaattacctt1020 ctctttctttactatttactaccaacctagtacatgtgttgactgaattcttttcaaaca1080 atgttgagttatcatggtgcacctaataaattaacaccacagattacagcatccttgctg1140 attttctcagcaaagccagattagatggaaataaacaaagaaaatgatcctagagtgaat1200 ttttctagaaaatatctattatgaaccatgctgtttaaagtattagcttgaaggtgatgg1260 atccagctattcagaaaataactttcatataaccatgattttgcacagtatgaggtctta1320 aatgtgtggaaagagataaattttttatcattaccacaaaccccttttaaagattcaaag1380 gtggaagaaagtgatttattttttctcttcagcatacatatataaaagacttgtcagatg1440 tttaatttggggaggttgataatgaaacatatcaacagagtatagtagttatagtagtgt1500 ttgtgggtaaataatttcctggggtcagacatatataaacatatttgcttcaaaatgata1560 aaggcatgaaatcagtcttaaaaattgaaatgggggtgatgggggagaaaaagaagaaca1620 aatttgaagtgccctttcaaatctgctggatacaagtattgaagttttaagtcatcttat1680 tctgtctgaaagtgtatttttcattctacaatagacccaatcaacaagacgtataacttg1740 agttgcatgatgttcagtttatgtaatctactgttgggatggtaagaattgatgtaggct1800 gtggtgtaagaatgaattaaaatatagtttcactggcttttctctacatatccactatca1860 caatggctaggtttcctgttgctcactgttggattctggagaaaaatttaatgaaagatg1920 atatcagagg aagaataagt ggaggtagag aagaaaggag tgatagagga ggggaaaaaa 1980 acaaaacata tttttgtgtt atccaaagga gctttttcct tattctgtca agcattgaga 2040 tcttcttcag ctttcaatgt agttgctaaa tacaaataat gctactaggt agtgactaaa 2100 tatagcaaac acttcatcag atattagaat taggtcacac tattgaggtt ataatctgaa 2160 ggttgtgtta catagaaacc actttagatt attatcaact tgggctaggc tttattttat 2220 aatagcatag taagtaatat ctattgtgtc atttcttcaa ccattttatt ctaagatcca 2280 tgaagcttct tgaggccaaa taaaataata agtttagaca agaagtagat tgtgactttt 2340 tttcccttag agatactatt tactatctcc tatcctgata ggtggaaggt ttactgaatt 2400 ggaaattggt tgactattag tttttaacta aaatgtgcaa taacacattg cagtttcctc 2460 aaactagttt cctatgatca ttaaactcat tctcagggtt aagaaaggaa tgtaaatttc 2520 tgcctcaatt tgtacttcat caataagttt ttgaagagtg cagattttta gtcaggtctt 2580 aaaaataaac tcacaaatct ggatgcattt ctaaattctg caaatgtttc ctggggtgac 2640 ttaacaagga ataatcccac aatataccta gctacctaat acatggagct ggggctcaac 2700 ccactgtttt taaggatttg cgcttacttg tggctgagga aaaataagta gttcgaggaa 2760 gtagttttta aatgtgagct tatagataga aacagaatat caacttaatt atgaaattgt 2820 tagaacctgt tctcttgtat ctgaatctga ttgcaattac tattgtactg atagactcca 2880 gccattgcaa gtctcagata tcttagctgt gtagtgattc ttgaaattct ttttaagaaa 2940 aattgagtag aaagaaataa accctttgta aatgaggctt ggcttttgtg aaagatcatc 3000 cgcaggctat gttaaaagga ttttagctca ctaaaagtgt aataatggaa atgtggaaaa 3060 tatcgtaggt aaaggaaact acctcatgct ctgaaggttt tgtagaagca caattaaaca 3120 tctaaaatgg ctttgttaca ccagagccat ctggtgtgaa gaactctata tttgtatgtt 3180 gagagggcat ggaataattg tattttgctg gcaatagaca cattctttat tatttgcaga 3240 ttcctcatca aatctgtaat tatgcacagt ttctgttatc aataaaacaa aagaatcctg 3300 ttaaaaaaaa aaaaaaaaaa aaa 3323 <210> 62 <211> 737 <212> DNA
<213> Human <400>

gggaatgccctaacaacacccatgcttgtgttgctgggagctgacattcaagaaaagtgc60 attaaaaattccttgagaaggcatattcttttgagagccgtaaatgaaaagtgcattcac120 ggagaacatgctcctttgttgtgagaggaaagaaaggactgttgttgcctttaaggaaca180 ggtttcccagttccccggaatgtcagggtcacatgaggaatgggtgagcacttagggcca240 agattgtcgtgtgcttggcccggcagcttctctctaagtgacctctccagcatcactctg300 tgccagtgctcatatctgaggccacttgagtgtcacgaggcagagcctggaaacattagc360 tttggaaaccgttccttcctttttatgtggaggaaagtaaggtttcacaagacacctaag420 ctggacatggtgatgtgccacttggatagttcccaaaagcagaaagcagcaggacatccc480 agtaccccacttctccgtgccgtgtactttcagggaggttctcgaaagctagcttcttta540 ccgatgatttgtctatgtactggttatggtggaaaaccttgcatttattacctggtccta600 tctcagagtcttctattcagcattcaatatgacttctaatgcttctaattggactgtatg660 gacagagaaccggtttgtcattcacgggccgcggatataatcagagcctggaatccgcca720 aaaggtcggtgccggat 737 <210> 63 <211> 3780 <212> DNA
<213> Human <400> 63 tactggacaa acatttcctc caaggacaca gctctctgcc tccatgtcac cacctttgaa , 60 ggactgactg attccctcgg ctggtgccag tgcctgctcc tgccatgggg cccgcgggga 120 gcctgctggg cagcggacag atgcagatca ccctgtgggg aagtctggca gctgtcgcca 180 ttttcttcgt catcaccttc ctcatcttcc cgtgctctag ttgtgacagg gaaaagaagc 240 cgcgacagca tagtggggac catgagaacc tgatgaacgt gccttcagac aaggagatgt 300 tcagccgttc agttactagc ctggcaacag atgctcctgc cagcagtgag cagaatgggg 360 cactcaccaa tggggacatt ctttcagagg acagtactct gacctgcatg cagcattacg 420 aggaagtccagacatcggcctcggatctgctggattcccaggacagcacagggaaaccaa480 aatgtcatcagagtcgggagctgcccagaatccctcccgagagcgcagtggataccatgc540 tcacggcgagaagtgtggacggggaccaggggctggggatggaagggccctatgaagtgc600 tcaaggacagctcctcccaagaaaacatggtggaggactgcttgtatgaaactgtgaagg660 agatcaaggaggtggctgcagctgcacacctggagaaaggccacagtggcaaggcaaaat720 ctacttctgcctcgaaagagctcccagggccccagactgaaggcaaagctgagtttgctg780 aatatgcctcggtggacagaaacaaaaaatgtcgtcaaagtgttaatgtagagagtatcc840 ttggaaattcatgtgatccagaagaggaggccccaccacctgtccctgttaagcttctgg900 acgagaatgaaaaccttcaggagaaggaagggggagaggcggaagagagtgccacagaca960 cgaccagtgaaactaacaagagatttagctcattgtcatacaagtctcgggaagaagacc1020 ccactctcacagaagaagagatctcagctatgtactcatcagtaaataaacctggacagt1080 tagtgaataaatcggggcagtcgcttacagttccggagtccacctacacctccattcaag1140 gggacccacagaggtcaccctcctcctgtaatgatctctatgctactgttaaagacttcg1200 aaaaaactccaaacagcacacttccaccagcagggaggcccagcgaggagccagagcctg1260 attatgaagcgatacagactctcaacagagaggaagaaaaggccaccctggggaccaatg1320 gccaccacggtctcgtcccaaaggagaacgactacgagagcataagtgacttgcagcaag1380 gcagagatattaccaggctctagcaacccagaagacaaccctgggtagcctgtgatcagt1440 gtctggagacgtttcttctgtggaagagaagaagtgacacaaacctatacttcatatgct1500 gctttagtcacctgaagatggttggagaggccctgtcgactgttctcccagttgttcagt1560 ttctgagacagagaggtacggactaggctgcacctgagtgtgcccctgcctgccagatgg1620 acaggtacacccaagcacatctccctgctgcaccctcaccacccacaaaagatcccagct1680 gtcagtggtctcatctcattagtgaggaaagccaagctgtatggaaaagctgcactcacc1740 aaggaccacaatgcccccggcctaaagtactgccattcagaaaagcaggtttttcttcct1800 ctctttccttttctctgtctgctactgactttaaggctttttcccccttgaaatgtccag1860 attcctgtggttcatcccaaggaaattttcacacaaagcttggcctttgccctcaatata1920 ggtgttttaggatggtgacaaaccatggctgctgctttctgcccagctcgccagtcctcc1980 ccaaagagttgcgcatcagcacctggggatctggaccctgcgggtgaagggatggggagg2040 gacgtccctggagtctcttctgtctttgttccttcttattttggcattcgatatcagcag2100 cctctccccaaagtacttgaagtcagttttagatgctttattttatttttctagtcaaaa2160 acgtgtttcccccagtgtttgaaaactcgtccgaatcttttcagtattttccatgagtat2220 tgtggtacttctagacttgtttaagcccagaactcattccttcaaaacagagagccttaa2280 tctttatgttgggacacagaccacatatttggacggcagccatgcatccatcgctgaagg2340 gctgtggacatgaatgtgtatttcccatggtctccgctgcccacaccaacagtgtggcat2400 ctcataagttaactgctaccctaaggtaatctaagattaaaatgtaaacatttatttttg2460 ttatgtaagtttataagatgttttatgttcaatgcctaatttctcaaaagtgccagaaaa2520 aaatgtatattagctattttgattttatgtacaatgatttatactctccttttgaaaaga2580 taccataaagcacataagctagatcactacaaggagctgttatcttttttctaatcaagt2640 gtttaaaacactgatggtttttaaagactcacctttttaaatggtacttggagctcctga2700 ttcaaattacctagaccccctagagaaataaatggaatatacataaataatcattttcag2760 tggtttatggtgggcaatattgcaatatttgaaatggtaaaaatggaaagaagaacaaaa2820 tatgatgagaggtggctgtgaattataaacctcataaaagtgtcataattccattaaggt2880 ttaattatattttttcagaaaacagtgatgaattctgtagtccagtgcttgccaatgcaa2940 attgcctattggaatcttcttcctatattttacaaacatcagtggctgaaatagctcaga3000 gtaagagctcagcctggtttgaatttaatcatctctttagatcttataaggccagcatta3060 ggaaacttgttcacttttcattttcaaaggagcctagttgaagtgctattatgagtgtgg3120 gctatggaaagacagcttttcctacactgataaagaaaaaaaatgaggaaattatttcat3180 ccccttgtgacatctgtgactttttggatttaataatcttgctgtttttcctctttatga3240 caaagaatataattgggaggatgaagtgtcttaaaaattgtagagaccagctcactggaa3300 tgtttttccatccctgtattcatggcttgactttgtgactgctctacactgcatgtctga3360 cattgcagagtgagctatgttgaggtaaactggttggttgtcattattttgcaatcagcc3420 tggtctctcccatgaagatgtcgtgtgcataagcacaatcatcactgattagaagatcac3480 agcagaatacccttggattagagagaagttcgtaccttgcatttctctgaattctagtct3540 ctcataagcactgctttgctggatgattttcactgctttgtgttaatgactttgagcgat3600 ctctcacatgatggggttctttagtacatggtaacagccatgtcatcttacacacctagc3660 attgtgaatgctgtagtgacatcctttataggcaccttacagctcaaaacttttgtttca3720 tttcatgccttacttatcaaaaaggcaggaaagtaggtatgatctctaaagtaaaaaaaa3780 <210> 64 <211> 437 <212> DNA
<213> Human <400> 64 gtgatggtgg gtttttgttt tattttttat aaaacacttg cactcaagaa catacaaaca 60 gtggccaccaatccccacccctggggctccggggagcaccatggcttgtttgtggctgtt120 ttcctctgtcccttccctggcatctggtgccagagggcaggtgcgggggtcctggggcggl80 gtggaatttgtacagcactttcatggggagatggtcacaagaaaggaaaccaggacaaga240 taaggactaagtctagggcacccacaaagatggcagacgaagcccatgaaagggcctgcg300 acagagtgaagagacggatgggcctgcgttggcctcagctagctctggaggctctgtggg360 ggaggggcaggtgggccttgcagtcaggattcggtaattacactttgctcacgggtagca420 ccttcggagtcctcctg 437 <210> 65 <211> 566 <212> DNA
<213> Human <400> 65 tacgttttat caactgccaa gatcctttat tttttccagg ccccttcctg cccactccac 60 atcggggcagctccagcataagggagatgacatgatgaaggggctaagagtagggcctgg120 ccagcatccactgagggcccaaccagggaacagttgctagccgctctcttccatgcagct180 ggagcactagcaaggccttccagaggctcccagggcgacctccacatcactcccgcttgt240 ctctgccctccagggtgctccgggcctcctctccctgtgtaccctagaggtgtgagggcc300 acagtcctcctcaggtgaacctccctccccaagcccagggccctagcacaggctgcagtt360 ggacggcttcgagctgcggctctgggcctgctgccgctggtattctgcctcactggctga420 cagtgcttgtgctaaagctaggtcttcttcctcctgacaacttggaaactggggtttggg480 ttctgccagggacatttccagggcccctgcagagttcatcctcactcaggccatttgcaa540 gaatcactgg aggggctgtc agaagg 566 <210> 66 <211> 566 <212> DNA
<213> Human <400> 66 ttttttttga gcaaagagct ttttattcaa agaaagaggc aaattgcacc caatctctct 60 ccctgtaaga tctcatctgg ttttgacatc agttgcaatg ctttcagtct gaggctaagc 120 aaaatgttat gctgtgaatg gtcaccacag agagaccact gtgttgctgg tgtggggagg 180 cgaggctcag ggttggacag gttaattacc tacataaccc tggctgtggc ccagcccagc 240 acctcccaaaacagggactgacatggctgaggtctaccttggagatggggtcagtgaaga300 ggggaggcagggtcagcctctgtgcaagtaaaatgccccctcaccccagccttcctttcc360 agagcaaccaatctgaaaacagaattgcctttggggctggtgttgtacctctgctttcag420 gccaagatggattccctagaagaggagtttgaagcccaatgtgcaaggacatttctcaag480 ggccatgtggttttgcagacactgctgtcctcaggcctgaactcaccatggaaacccatg540 tcagcaaacagtgaccagcaaatcct 566 <210> 67 <2l1> 3510 <212> DNA
<213> Human <400>

agaagccgttcagatgtgagaactgcaatgagcgcttccagtacaagtaccagctgcggt60 cacacatgagcatccacattggccacaagcagttcatgtgccaatggtgcggcaaggact120 tcaacatgaagcagtacttcgatgagcacatgaagacccacacaggagagaagccgtaca180 tctgcgagatctgtggcaagagcttcaccagccggcccaacatgaagcggcaccggcgca240 cgcacacgggcgagaagccgtacccgtgcgacgtgtgtggccagcgcttccgcttctcca300 acatgctcaaggcccacaaggagaagtgcttccgcgtcagccacaccctggccggcgacg360 gcgtccccgctgccccaggcctgcccccaacccagccccaggcgcacgcactgcccctgc420 tcccggggctgccccagaccctgccgcccccgccccacctgccgcccccgcctccgctct480 tccccaccactgccagccccggcgggaggatgaacgccaacaactagctgccgagctgca540 cccgtgcacccgctggggcctggagtcagggcccactccaggagggacccactgccttcc600 cggggagcacagtagtgcgggcctgggccctgctccacctccagaagtggctggatgtac660 cctgcctgaggccccgacgaggaggggtatgcaggctggcaggccccagagctggtggag720 ggcatctcactcccaagtgccccccctttctgtgactccttgaagcctttactttttttt780 ttttttggaagtgaaggaaaaagaaactatttacagcactcccctccaggtgaggggggt840 gctgggggtctgcagcagaaagaaaggggcctgggcagcaggtgtggccagtccctctgc900 caaggcctgtgccagaggggttggccagttggagcctgggtcagcctcagcagcctatcc960 ccatgtcctctatgcccctaatttgcttcctcatcttggagggtttggggagaagttggc1020 gtgccacccccacaacccctgaggaggtgtagacccagtctgagagccgcaagcactgag1080 gcagggcctgagactggacctgggtgagcgtggggggtggagggtggcgaggtgcggaga1140 ctgcagaccagtgcttcactgtgtggagtggggcaggcaggggctggaccccagggactt1200 gccttcccca cccactctgc tgccagcagg cccagggatc cctgacctgc accaggtggc 1260 accaagggtc ctgagtcctg gagatgtccc cagaagctgc tgtgcctcac agcgctgtga 1320 gccagaccct ccttgggcag acaggctgac tggcagcacc agctttgggg gcagagtcct 1380 aggatgaggc ttgggcagtg ctggtagggt ttcaaggtgc tattagtggg gcaggggcag 1440 ggcggctgct cacagagcac cccagttcct caccagctac tctggccata tatcccacac 1500 cagaaggaac aagtgtggct gtgtccatct ctgctccccc aaaggcccgc tctaggcctt 1560 atCCtCCCtC taggtCCtgC cacaacctgt ccctggctgg ctccagcgtc ctcgtccctc 1620 ctgggcctgt gcaccggtgg gtggggcgcc catagcactg ccggtaaagg agcctgcatg 1680 ttcaggcccc tcgggggatt ggggggactg gggaggcgca gcctagaccc aattgcttgc 1740, ccccatgagg ctagcactaa taggaaaccc ttttttgttg tcatttaatg tctttattcc 1800 tgcctttaat atggggagga aggttccata agctacatgt ttcctagtta agctctttcc 1860 tattgtgttt atacagtttt gtttgttata ctctttgcac cttaaacccc caccactccc 1920 cgacactatt gccttcccag catggctgga gtgggaagag gcttgggccc cgggggaatg 1980 gttaggggga ctgaacccct ctgaccttat gaggcccatg gcactggggc agggagctgg 2040 ggacatttta atcatcaata aacgaagcac tttattctgt acagatttgg gcaggcccaa 2100 ggtgcccgag tgatctgagg atttataatc caagccacac caccctggtt gttctctggg 2160 cttggagggt acagtgccag cagcttcctt gcccaattga tgttggagct gtagacgtac 2220 gctcaggcgc tcctgctgtc ctgggggaga gaaggttcgc ccctccccga ggaagaaggc 2280 ttctggtcag gacccccacc ccaaggctgg ggactccagg ctcctgcttt actgtagctc 2340 tttttcttcc ttgcactcct tgatctttgg gcttccgtga tgtcctcagg gtccccccct 2400 ccctgttgct atttttaatc tctagtccca gtgcctggca gctctttgga gctggctcac 2460 attttcccaa aaaaaagttg atctctccca gtgggctgta ggcagggtcc tccatgggtt 2520 tccaaccccc atcactggca ccaggatctc ccacaggcac tggtggtgtc atcacctgct 2580 ggccccacta cagcctgagt aggcctgagt ggccgtggcc aggctgagac ctgtcaggcc 2640 atactgacaa gcagaggtca gagacactgg tggggagctg gcaatgaaac cctgtcctgg 2700 gacatgggtt tcatgttctt gtacacttcc cctctgggat caggtgaggg gtccagacag 2760 ctgaccagac agcttgacag ctggtcaaga cggtcacggg agctctaggt gggcacaacc 2820 aacccctctc ctgggaggcc cctgccccac tggggatagg agcctgtgtc cctggtgcta 2880 agcactctct tcacttgggc cattgttggt gggggctcct ttccggccag accacaaggc 2940 cagaagcaat aatggcacct cagcagttcc agtatggata ggggttactg ttttactagc 3000 ttttacatct ttttatttaa aacaaaacaa cacaaaaaaa caatgtgccc ccagatgtca 3060 gaatgaggcgactagggcaccatactcactttccagggctgggggaagggggacgcagga3120 tcatcccctcccaaggagatctgtgggggtcccaccgtccatctggacttctcagcctgt3180 ttggctagaactcaggcctggagtctgggtctgccccctccccggctccttggggctctc3240 tggtctcaggccagctggcgatgggtggctagagtgatgaactcaagccctgtggccaca3300 gttctgggagccttcaaccctggctcatgctgccatagtctccacggtgcccttcacaga3360 gggcttggtagtggcagaatggccatgcccaggtgtgtgttgagaccattgacaactgct3420 cgtgtacaggcaccccacagccccagagcatggggcacagcaggcatgcgagtgagagga3480 tgaaggggaataaagtcagtacaactcgtg 3510 <210> 68 <211> 2800 <212> DNA
<213> Human <400>
68 ggggcactgaggcctccccacctcagaacaacagcggcagtagttctcct60 gcctcccccc gtcttcaccttccgccacccgcttctgtcatctggtggcccccagtccccactccgagga120 tccacaggctccctgaagtcttccccgtccatgtcccatatggaggccctgggcaaggcc180 tggaaccggcagctcagccgtcccctctcccaggctgtgtcattcagcaccccctttggc240 ctggacagcgacgtggatgtcgtcatgggagaccctgtgctcctccgctctgtgagctcg300 gacagcctgggccccccgcgtcccgcgccggccaggacccccacccagccacccccggag360 cctggtgacctgcccaccatcgaggaagctctgcagatcatccacagtgccgagccccgg420 ctcctcccagatggggcggccgacggcagcttctacctccactcccctgaggggccctcc480 aagccatccctggcctccccctacctgcccgaggggacctccaaaccactgtccgacagg540 cccaccaaagcaccagtgtacatgccacaccccgagaccccctcgaaaccatctccctgt600 ctggtgggggaggcatcgaaaccgccagccccatccgaggggtccccgaaggcggtggct660 tcgtccccagcagccaccaactccgaggtgaaaatgaccagctttgcagaacgcaagaaa720 cagctggtgaaggcagaggctgaggccggagcggggtcccccacgtccactccggccccg780 ccggaggccctgagctcggagatgagtgagctcagcgcccggctggaggagaaacgcaga840 gccatcgaggctcagaagcgacggattgaggccatattcgccaagcaccgccagcggctg900 ggcaaaagcgccttcctgcaggtgcagccgcgggaagcctctggggaggcggaagcagag960 gcggaggagg ccgattccgg tccagtccct ggtggggagc ggcccgcagg cgagggccag 1020 ggtgagccaa cctcacggcc caaggcagtg accttctcgc cagacctggg cccggtgccc 1080 cacgaggggc tgggggaata caatcgagcg gtcagcaagc tgagtgccgc cttgagctcg 1140 ctgcagcggg acatgcagag gctcacggac cagcagcagc ggctcctggc cccgcccgag 1200 gcccccggat ccgccccacc acctgctgcg tgggtcatcc ctggccccac gacggggccc 1260 aaagctgcat cccccagccc cgcccggcga gtcccggcca cccggcgcag ccctgggccc 1320 ~gggcccagcc agtcaccccg cagcccgaaa cacacgcggc cagcggagct gcggctggca 1380 cccttgacca gggtgcttac gccaccccac gacgtagaca gcctccccca cctgcgcaag 1440 ttctcgccga gccaggtgcc cgtgcagacg cgctcttcca tcctcctggc ggaggagacg 1500 ccccccgagg agccagccgc ccggccgggc ctcatcgaga tcccgctggg cagcctggca 1560 gatcccgccg ccgaggacga gggagacggg agccccgctg gtgctgagga ttccttggag 1620 gaggaggcgt cttcggaggg ggagccccgg gtggggctgg ggttcttcta caaggatgaa 1680 gacaagcctg aggacgagat ggcccaaaag cgggccagcc tgctggagcg gcagcagcgg 1740 cgagcagagg aggcgcggcg gcgcaagcag tggcaggagg tggagaagga acagcggagg ; 1800 gaggaggccg cgaggctggc ccaagaggag gccccgggcc cagccccgct tgtgtccgca 1860 gtcccgatgg cgactccagc ccctgctgcc cgggctccag ccgaggagga ggtgggcccc 1920 cggaaggggg acttcacgcg gcaggagtac gagcgccggg cccagctgaa gctgatggac 1980 gacctcgata aggtgctgcg gccccgggct gcggggtccg ggggtccagg tcggggcggg 2040 cggagggcca cccggcctcg ctcgggttgc tgtgacgact cagccctggc acgaagccca 2100 gcccgcggcc tgctgggctc tcggctgagc aaaatctatt cccagtccac cctgtcactg 2160 tccactgtgg ccaacgaggc ccacaataac ctcggggtga agaggcccac gtctcgggct 2220 ccctccccgt caggtctcat gtccccaagc cgcctgcctg gaagccgcga acgggactgg 2280 gaaaatggca gcaatgcctc ctccccagcg tcagtgcccg agtacacagg tccacggctg 2340 tacaaagaac ccagcgccaa gtccaacaag ttcatcatcc acaatgccct atcacactgc 2400 tgcctggcgg gcaaggtgaa cgaaccgcag aagaatcgca ttctggagga aattgagaaa 2460 agcaaggcca accacttcct gatcctcttt cgcgactcga gctgccagtt ccgggcgctc 2520 tacacgctgt cgggggagac agaggagctg tcgcggctgg cagggtatgg gccccggacc 2580 gtcacgcccg ccatggtgga aggcatctac aagtacaact cggaccgcaa gcgcttcacc 2640 cagatccccg ccaagaccat gtccatgagc gtcgatgcct tcaccatcca gggacacctc 2700 tggcagggca agaaacccac cactcccaag aagggcggcg gcacccccaa atagccccac 2760 ccgggcggtc cacgggccgg gccctgtgtg ctgcggccgc 2800 <210> 69 <211> 1634 <212> DNA
<2l3> Human <400> 69 aaaggtaaga gcactttatt cttatttgaa ccacactgta ttgttgatta ccgagtgtga 60 aggtagtatg ttcagagtct tgttttatgc ctttgtagct gtgttgccag catttgaagg 120 taactcctcc acataagcgg caggaaaatg gccttttttc ccattcaaag atccaaacca 180 ccatccttct tcttttttct cgtgtataat cacaatgtca cccttttcca aattcaactc 240 atcatcttgcctggcttgaaaagaatacaaggccttgcaaagtctgctgctgagctgggc300 tgcaccaggggctggagttgaagaacctggattgctctgcccaccagaagatgccttgct360 cacaatattctctaatctcttcattaaaaaaggccgagatattttcacatagctatgagt420 atgctccttttccctccacctgaagatggaattactacaaggatggctgggttgaggtct480 ttgctcaagttctgctaacattgatgacagtttgtaggagttcgcttccaaaaggtctag540 tttcaaattgttctcatccattaacgctgctgtgtctttctggctctttgcatcagagaa600 ggaggaggtgctggagtacgttttaagcattcgttccaggccttccttgtcttttgaggc660 tttttcaatgtctctctgcagtctcaataattttggttttagtaaagactttcgtctctc720 tttatccattgcactgttaggatcttcttcaaagtaatccgttaacaggaactcagattt780 gttttctgtagataaaattgcagtttcttccattacagcctggatatctttttcaatgtc840 aatcttgctgatggcacagtgaatctgcgtgtggcatgtggtcagggtttggccaaaaag900 agaaatatgttggctgtactggtttaagttattgcataaaagttgaattctttccttctc960 cagctccagaatgctctggtagcagttctctagtgtgttttcccatttcagtctggtaga1020 ataacccgccatgtttttttggtagtaattttcatcttccttttccaacttttcagttga1080 ttttgtcagtttattgaggagcttccgcttctccttctcagtcatagattgcttggagct1140 ttctacaagctggaaaagtgcttcatgtttcttggtactaaccattaatttcttcttggc1200 cttaatttgctgattccagttgctaatgacaagatttgctgtcttttcaacttcattgtc1260 aagtgattttctcttcttctcttgtacatttaggacttgataagtcggttttattgcttc1320 caattcaattgctttgccaagtttttgatgcaggtccgctgtggatttcattccctctga1380 ggcccaggcccaggcactgctaacacaactttttctcgtgttctgtaatgctttgctcag1440 cttgcttgccagtttctgaagtcctttggcatagctaatttccaggtttgccctttgctg1500 aagaacagat gtgacctgtt tgcagaaatt ctctccattt tgagaaaact cctttaggtt 1560 cttgtatact ttattatacg gacaatctgt cagtgggtcc ctcatgttga aatgtgtctg 1620 gcttttgtcc tttc 1634 <210> 70 <211> 774 <212> DNA
<213> Human <220>
<221> misc_feature <222> (465)..(465) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (509)..(509) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (617)..(617) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (636)..(636) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (667)..(667) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (693)..(693) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (740)..(740) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (762) . . (762) <223> n is a, c, g, or t <400> 70 accaaaccaa atcattttat tgtgcaattt ccttctacca gaaaattact aaaaatataa 60 atattaactc tctaaaaaat actcagaata gatctgtaat cttcctcctc ctcctccgaa 120 ctggagccaatcttcttctttaaacgctgatggattgcatacatgtatgtcttccatatc180 agccacatacacaacattcagatacacttccctctgtgcagggggatacaccagcctcct240 gccaggttctggaagctcaccttataatctaccaggataaagctgtgtgctgagtaggag300 gttatggtggggttggggagtaacaaggagataaaagaccttgtggtcccaacttcctta360 tgtggacagagaagataggtcctttactcctcctcattaccctgccctctcatggactgg420 gctaactgaaggccaagctcccagagaagctggactcactgtgtnggattactgagggtg480 tggctgccaggctacagtcacaggaaggncagactgttgagatggacatggaaaccaggt540 gaggcttggatggaaagctggtctgggccaagggctctggcaggatgagtagtaagctgt600 ttcctggctgggctttnggcagcccctagaccctangcaccaggtactatgtgcagcatc660 ttaaganccagacaccagtcttcagagagcctnccgaggtagccgcaacattcctgcagc720 aggggacgggcaggttgtangcagttagattggagccaggtnccatggcactgt 774 <210> 71 <211> 578 <212> DNA
<213> Human <400> 71 tttttttttt tttttttaca tgcaatacca caaatttatt ataatacaca gggaaaaaca 60 aactcaaactttgacaacatccacagaatgttccagtctttaaaaagttagcagaaataa120 agggtaatggaaagaatataatctcgtaattttatacttaaggctgtaaatggcaaagtc180 ccatagatatttaaaaatctatatttgtatttatttataatatagatataggccctcaag240 gattcatagagatttatgtaataaactagattttggtactatttattttgttgttgttgt300 tgcttgttaggtaagcaaacccaaacaaattaagtcctgaaaagtgggatgaaatcccaa360 aggaactctatgagaccacacagaactcttttaataaatatggcccatacaaattccata420 tccagtgaaaatcattttgatccacaatcatgttgatgtttctatggaggatacttctag480 cagctgtgatttcttttgtagcattctggctctccacttctattcatataattgagtatg540 tgttttattacatgttagcttataggcaagttaaacat 578 <210> 72 <211> 475 <212> DNA
<213> Human <220>
<221> misc_feature <222> (285)..(285) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (361)..(361) <223> n is a, c, g, or t <400>

gggtttgcacagtttattaagataatcaatcaatttcttaagttattcctttgttaacca60 gacagcatctctggagagaaaatgcactctctgtgtagatacataaaaatacatcagtca120 ttttgcccctcctggatgtgaacggaatctcccctcctcacctccacagagggagctcaa180 gccccagggaaccttcccctccccttttatgcattaccaggggagtggcaggggcagccc240 ccaactgtggagtgcattcaggtctgaggggggaggaaggctcanaggggcatctcccca300 gcaccctgccacagtgctggcttctggggtgtttgttcagcggcctgctgggctgcccca360 ngctgggggctcccccagctccccgtgcatcctggcttgttccacggagccctgagccaa420 gtctttgtctggctcatgttcctctcacaacatcccacaggcaggggtgagcctg 475 <210> 73 <211> 512 ' <212> DNA
<213> Human <400> 73 catgtaaaactgacttttattacaattaaaaaagaacaaagacaatttgataagtgcctt60 taattacaacatacctgctatttacatgtaatcatacttttatatatagcttgaataagt120 tttattacatgtaaactataagatattacaagttaaactccagtcttttctggatattca180 attgaaatactactggcagaaacatacagaaaacaaatacccatttcagttcctcaggta240 ccattactggttgaatgatcaagatctggccacagaagagaagtggaaatatgcatcaaa300 acaaaacttattcttaacatgactaacagtattgttatttaaaccctaaacataattaat360 aattggatcattaaaaacacatcttcaatttatatagcacctttcttccgaagagttgaa420 agcattcgtgcttatctctattatttcgtttgtccccataacatctctatgaggtaggca480 atggttagta tcattatccc cattttgtat at 512 <210> 74 <211> 668 <212> DNA
<213> Human <400> 74 tttcaaaacc agcaaaaatt aaatttaatt gggctcaagt ctgggcagtt tgtccttcct 60 caggaccagc cgtcagcagt ccctgacgaa agcaccccat tctctccaca gacagctggt 120 tccaaaaggaccctctgaggctggtcttccgggtaggatgtgctgtgggagggttctgtt180 tccgaggaggagaggcgcgacacagcgtgcaaggacctgcagcaccttccacgcagcacc240 ccctgctcctcctcctcagcccctgccgggctctgactcctaaagtaaggcaggagcttc300 ttcaggcccctggctgaggaagagccacagccaccctaaaatggcttcgggggcatgcag360 ccctccatctccagcagctctggccatccctcgtatttgttggtgtctgggctgttcttt420 aagaactgctcaaaggggctgttacccctgaggtctttggctcctatgaagacccagctg480 tcccggaagcccagttgttttgcgtaggaactccccaagtcagagaagagtttcctgctt540 tcatcgatcattttggtcgctggatcgtcgtaggaggccaccaacaccagtgcaccccgc600 ggaaatatcttatggaatttcactaggtgcataacttctcctaagtgcatgtcaaatgcc660 tgctggcg 668 <210> 75 <211> 568 <212> DNA
<213> Human <400>

aaggaataaggtgaatttttattaagtgaaaaaaatcaataacaatataggaatgatcac60 atctatacaaatacattgctacatttctacatataaaatgtataggaaaaagtctgaaag120 aatgcacaccaaattattctgtttttaggaaaagcagtaggattggtcagggcatggaat180 gtcggctaagtgaagtgagatttaaaatttttattctacatgattttctagtgttgggaa240 tttttgacagtgagcatacatgcacttattacttgcataattctgaaaactattttaaaa300 acaacagagaatatatgaaagtctattggtgtatacagcattaatagtagtgaaagttta360 acagaaaagatctgaaaatctcccaaagttatatagaaacagatctagctgacacactgt420 gtacctagaaatgattttggatctcttcacagagacccctatcccaccaacctccaatcc480 tcccaccatacattgatccctttctatctgcttggatcattagctgtaaatttaacttcg540 aaaaacaaagtacgtttaatcattgtac 568 <210> 76 <211> 491 <212> DNA
<213> Human <220>
<221> misc_feature <222> (371)..(371) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (394)..(394) <223> n is a, c, g, or t <400> 76 ttagattgaa gaaaacataa cgtttaattc tcagaaacaa atgcaagcct cggtccaagt 60 cttccttcccaaacctttgtcatttagggattgagaagctgagttgggtgaaaggttgaa120 tagaaaacaaaaaggaaagctagaaacacgctgagctcatggagatgcagcttcttctgt180 agctcctaaaggcccagctgaggtatcatctaatgagaattctctctatgccaggcactg240 cgctaagattttcacatcattaaccaatgtgagttttaggcaaccccgaagcaggcagtc300 tgttcatcccaattgcagctgaggaaacaggggtgaggtgaggccaagcagctgggccca360 agggtcccctncctgggtaagtgggcacagctgncagccctgccagggtggggtcctgct420 aaccaagccggcgttttcttgtcaccatgccgtattcgccttcccgtactatcaaaatgt480 acttatccaat 491 <210>

<211>

<212>
DNA

<213>
Human <400>

tcggatccactagtaacggccgccagtgtgctggaattcgcggccggtcgacccaccacc 60 atgaggtcctgcctgtggagatgcaggcacctgagccaaggcgtccagtggtccttgctt 120 ctggctgtcctggtcttctttctcttcgccttgccctcttttattaaggagcctcaaaca 180 aagccttccaggcatcaacgcacagagaacattaaagaaaggtctctacagtccctggca 240 aagcctaagtcccaggcacccacaagggcaaggaggacaaccatctatgcagagccagtg 300 ccagagaacaatgccctcaacacacaaacccagcccaaggcccacaccaccggagacaga 360 ggaaaggaggccaaccaggcaccgccggaggagcaggacaaggtgccccacacagcacag 420 agggcagcatggaagagcccagaaaaagagaaaaccatggtgaacacactgtcacccaga 480 gggcaagatgcagggatggcctctggcaggacagaggcacaatcatggaagagccaggac 540 acaaagacgacccaaggaaatgggggccagaccaggaagctgacggcctccaggacggtg 600 tcagagaagcaccagggcaaagcggcaaccacagccaagacgctcattcccaaaagtcag 660 cacagaatgctggctcccacaggagcagtgtcaacaaggacgagacagaaaggagtgacc 720 acagcagtcatcccacctaaggagaagaaacctcaggccaccccaccccctgcccctttc 780 cagagccccacgacgcagagaaaccaaagactgaaggccgccaacttcaaatctgagcct 840 cggtgggatt ttgaggaaaa atacagcttc gaaataggag gccttcagac gacttgccct 900 gactctgtga agatcaaagc ctccaagtcg ctgtggctcc agaaactctt tctgcccaac 960 ctcactctct tcctggactc cagacacttc aaccagagtg agtgggaccg cctggaacac 1020 tttgcaccac cctttggctt catggagctc aactactcct tggtgcagaa ggtcgtgaca 1080 cgcttccctc cagtgcccca gcagcagctg ctcctggcca gcctccccgc tgggagcctc 1140 cggtgcatca cctgtgccgt ggtgggcaac gggggcatcc tgaacaactc ccacatgggc 1200 caggagatag acagtcacga ctacgtgttc cgattgagcg gagctctcat taaaggctac 1260 gaacaggatg tggggactcg gacatccttc tacggcttta ccgccttctc cctgacccag 1320 tcactcctta tattgggcaa tcggggtttc aagaacgtgc ctcttgggaa ggacgtccgc 1380 tacttgcact tcctggaagg cacccgggac tatgagtggc tggaagcact gcttatgaat 1440 cagacggtga tgtcaaaaaa ccttttctgg ttcaggcaca gaccccagga agcttttcgg 1500 gaagccctgc acatggacag gtacctgttg ctgcacccag actttctccg atacatgaag 1560 aacaggtttc tgaggtctaa gaccctggat ggtgcccact ggaggatata ccgccccacc 1620 actggggccc tcctgctgct cactgccctt cagctctgtg accaggtgag tgcttatggc 1680 ttcatcactg agggccatga gcgcttttct gatcactact atgatacatc atggaagcgg 1740 ctgatctttt acataaacca tgacttcaag ctggagagag aagtctggaa gcggctacac 1800 gatgaaggga taatccggct gtaccagcgt cctggtcccg gaactgccaa agccaagaac 1860 tgaccggggc cagggctgcc atggtctcct tgcctgctcc aaggcacagg atacagtggg 1920 aatcttgaga ctctttggcc atttcccatg gctcagacta agctccaagc ccttcaggag 1980 ttccaaggga acacttgaac catggacaag actctctcaa gatggcaaat ggctaattga 2040 ggttctgaag ttcttcagta cattgctgta ggtcctgagg ccagggattt ttaattaaat 2100 ggggtgatgg gtggccaata ccacaattcc tgctgaaaaa cactcttcca gtccaaaagc 2160 ttcttgatac agaaaaaaga gcctggattt acagaaacat atagatctgg tttgaattcc 2220 aggatcgagt ttacagttgt gaaatcttga aggtattact taacttcact acagattgtc 2280 tagaagacct ttctaggagt tatctgattc tagaagggtc tatacttgtc cttgtcttta 2340 agctatttga caactctacg tgttgtagaa mactgataat aatacaaatg attgttgtcc 2400 atggaaaggc aaataaattt tctacagtga aaaaaaa 2437 <210> 78 <211> 582 <212> DNA

<213> Human <400>
78 aattattatttatttcaataagactattgcgaggcattaaaaaaactaaa60 ttccagatca tagtaatattacaaaatctatatacttgcacatttagtatttgtcaatgtgccagaggtt120 ttcttcatgaaatttgacttctttgaagtgaaggcttttttctatcatctcttatagctc180 tgactgaataagtcttaatgctttcttcatgttttctatcaataggggtaaatcccgagg240 cttatatgtgtacaatctgttagagtatcttccagctatgtcagctctaactgttaaaga300 agggtctacaaacatgattctaggcacatattgcccatcaggtgataaattcttatcagt360 ggtttcatgcataaggtttagcatgatgaacttattctgagccatttcttgtatttcttc420 attttgggcaaatactttctttagtgcttgagagtattgacaatcctccaggtgatgaat480 aaccattaatggcttcttacttttttgagcataaaagagaccttgctcataagtttgtac540 ccaagagatggcatctacccatcctcttgagagtgactgagg 582 <210> 79 <211> 511 <2l2> DNA
<213> Human <400> 79 ttgaaagcct ttacatttat tgaagagcgg acatatgttt gcaaatcaca gtgtgcatgg 60 gcatgcatta catggttcat aatgctattc caattaggct tttcatagtg ccttctcata 120 acgtcctttaaaaaaaataataactgaaagggaaaagaaagtgtcaattgcaattacatt180 tacaaaaccaaactgctgctttcaattagagtgaatctgtgcttcgctactcagatatac240 acatgtagattttccaaggcccatgcacacacttctgtaggggcagaaattttctatgaa300 taatggctttagcaacccgaatagtatctctaaacattgacaagcttggggaacagggca360 acaagtgcaatgaacaatacaatttctaacgtttgtcccagtcaacataccactttgccc420 tggagatatttaacacagcatttcatttttggaatgataagggataattcatctaattaa480 gggtattatacagaatatacctataaaagac 5ll <210> 80 <211> 987 <212> DNA
<213> Human <400> 80 gtgatgatcg acatttgaat ctctttgccc tttccaacgg ctatggcatc aggttctaaa 60 ataagctcgt aatttttcct gttattttaa taatatggaa atattagcat agtgtttctt 120 ttgatagtga tagactataa tccatattta aattttatag.agaagaaatt ttattgtact 180 gtgatgtaga tatttattat ccaggtaagg atttgcccgg tgtgtatttt ttacaattga 240 gacattttac tttaatcttt aacaaaaaat gcattaaaaa cacactcaaa aaaaaacaaa 300 aaaaaaaaaaaaagacaacccaaacggggggggaaaaaagaggtgattggcaccctttat 360 cacgaaaatcttcctgcgggcggccctctaataaccagtcttctggaacaactgtgccca 420 aaccgaggtgtcgctctttaaaataggcgtggtctcccaccatatctaacactcaaatgg 480 cgccgcctcttctcaaaagaacccacaaatatgtgtgccgaccaagagttaaaaaacccg 540 ccttgcgttggacggggcggacattatcttggattggcaccaacactattaaaagaggcg 600 atgcgacacccaaccccgattaattggcagcagacagaaatcctttctcaactagtatag 660 aaaactgttgtggccctccaccacacaaaaggacgaatcctacccaactaatgtattagc720 tcctctccagtgtgaacaatatactaatctggatgcgcccacacccaagctggttagcta780 acacaaacaccagggagggaagacacacgcattttgtaacacaaatagatctaatattag840 actcgtgccgtataacatcggacactaatctctagcaccagcgggcgtcgactgtaatta900 tgtcccgccactgctgctgttcgtcggcatgttatcatgccccacgctctctgtgatcct960 acacgagagggatcaccccacgcttat 98~

<210> 81 <211> 483 <212> DNA
<213> Human <400>
8l ctgttcaaaaaaggttttatccaaaaaagttaatcaagacaagcaacagatactgcaaag 60 cattatatacagcaccatagtccaggggccaaagaaatcaggaggggctgggcagtagag 120 gaattccatatattaatgaatgtgagattaagtatagagtgaagacattaacacacaatt 180 ctaatttctgttaggcagaatgctcccctaccctgatgccacagcctttcacgtttccta 240 aaccctagtaacctctgatctccatctgcctcatcaacacgtcaccaccctttgctcttc 300 ttccaattagtcacatgttggctgaatttatttcactccagtactttaggaccttgacag 360 acaaatcgattacaaggtcaattcccaggatttcttcagggtgtgttcaggagtgcagat ~

gttctttggatgacctttctactaaattagacctctgaaggagaaagctacttgccagag 480 get 483 <210> 82 <211> 552 <212> DNA

<213>
Human <400>

tttttttaccacctagaaataaacattatattttcctctgatatgtaggtaagaacttca 60 aatataagacataatttaaaagtttataattgacatagtcagggattataaataatatca 120 cacaaaataagctcttaatgcaagaaatgaatctccaggatagatcatactaatctatcc 180 aatccagccctctgttctgaaagcagcacatgaaaaggcagagaaagaaaaataatctct 240 acgacctggcctgttaaacatgtatttatttcctgagtaactattaggtgctagctgtaa 300 tgggctattcagtggaggacagtggtcaaagcctcttatgatgtatggcagatgccagaa 360 agatatgaaagatgtgatggtacaaaaaaggaagttggagtcacatccagccacaggact 420 aactaagcctctttggggcaggagactttggaagtgttgaaggagagtagaatctattca 480 gaaagaaacaactgggggcaggtccttccagtctgaatgaagattaactaggcgtaatgt 540 aactggcatcat 552 <210> 83 <211> 505 <212> DNA
<213> Human <400> 83 gactgtagaaggaaagcattttattgcaaataactaatagttacaaaagcactttttaaa 60 tgttattattagatgttaagccgaaaatctagaaactaacatttacccaggttacaaaat 120 aagagcttcatatttttcaaagtctctaagggtaaggtacatccccagataaaatgagta 180 taggccagtctcctttggctttgtggattctttccaaaaattttccagactatttagctt 240 tccttgtgtagttacagctcaaattagaaactgaagaaacagcaagtggccaggcagggt 300 agaaagcaaataaactgagctacctgtgcctttttccaaatcagtatatgtgcttggctc 360 ctgaaaaaaaaaattctgatatgtaggcattctcattacttagtgagatattagtgaaga 420 cctttcaacgtataacacacagtaactgttgcatagttttaataaacacttgaattttcc 480 aggaatgtga ctgctgtgta aatca 505 <210> 84 <2l1> 671 <212> DNA
<213> Human <400> 84 gcggccgcgg ctgcggcggc agcagcactg gctgggtctg gctgcacagc aatggggctg 60 atcatgtgct ccactgtgtg gattttgcca tcttcaatca ttttaggggc tggagctgct 120 ggaaacatggaatactgagccccaatggcagggatggctactgtaccaggtttaatggca 180 actgggttgacggtagggatttccaaattcggcaccagttcatatcctttttcttgctgc 240 tttcctttcccttcatgatatcggctatatataccacggccagcagaatatcccccgagg 300 taggaacccctaggccctggggctctgttgccagctgcacctcgccctcggcctcttatg 360 ctgcctgctttcacaaagtagtccctgttgggcccaatgagcgcgttgtaggggtagccg 420 tagtaggccagtgtgtaggggtcgcaggagtacacgtagctgggctgctgcgctgcctca 480 gccgcgccgccgcccctggctgccttctggtagcgcgagtactgctccttgtccacgggc 540 ttggccagcgtgacctccaggcacgagccctccagctcagtgccggttgagttgttcatg 600 gcatgcacggcatcctcgcggctggtgaagtgcacggaggcgtaggtccggatcttcttg 660 acgcgctcca c 671 <210> 85 <211> 563 <212> DNA
<213> Human <400> 85 tttttttttt atatctgtta taagcttttt cttttttaga atttaagctt atgagtttat 60 ctacgcccactatattcataattacagttttatatctgcatacaaaagctatgtaaaaat 120 ccatttttcccaaatatacaaattttttttggatagtttaaaacattttgatcacagatt 180 tcaacagagttttaggctgaaaaaaatatcaccatctagcaatatcacttaacactgttt 240 gcaaaacacaaatcttccaatgactgtaaatctttttctattctgtagtatttttctgat 300 tctcagggcatgaaaacattatgggaaaaaaaaggattttctacgaagaaagcatggaga 360 actaatttggctctatggtcaaattaaaaatgccaagttaataagggagaaccaaaagaa 420 agaagtggcataatgtcacatcagctcattcatgccctgataatttctgtatcaacaata 480 catatgtaaagtgtctccttttgtcttacattgtgctccataatttacatgagtattatc 540 tgcatcctgaggaggacagattt 563 <210> 86 <211> 545 <212> DNA
<213> Human <400> 86 ttattaggga ttcctgccac cttattaaca tataaaacaa tctggatgtt gacatagaaa 60 tgcaaatttc actatacaaa ggtaaggctc caagcacagt aacatggccc ccatatcttt 120 agtatttcaa tgaaataaac ttattgggga ttcaccccga gttgtgttta taaatattag 180 acaaaccaca aaatatattc caaatacata acattttaca atatttttca agcacagaca 240 aatacatact ttactttacc tacattgttt tcatgatcca acttgcatta gcactaaagg 300 caatattgtg tgtgtatatg tatttgccat atgtgtgtgt gtattatata tatttattta 360 tatccacaaa tgtacactca gtggcattta tggaaaattt aaccctttca ggctgtgggt 420 tttacccacc atagtatctg agagggagaa gaaccaataa tacatctcaa attcctcaat 480 tagggcaaaa taagcacaat tatgcatgag gggcatatat gttgtgtcta ttcaaagaca 540 cacat 545 <210> 87 <211> 464 <212> DNA
<213> Human <220>
<221> misc_feature <222> (28)..(28) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (276)..(276) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (422)..(422) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (463)..(463) <223> n is a, c, g, or t <400> 87 gcagcgtttg tccctgggca tgtgatgngg agtcctgggc acatcgagat gctttacttc 60 tttctttcga cctcttaaaa aactaaacca agccaaacca caaaggaaat ctgcacaact 120 taagagaaac ttgaaaggga tcgtgtaact actagtttgt actaagtttt tttcaagaaa 180 gggaaacaaa tttatatata tatatatata tatatatatg tgcaatatat ttttacactg 240 tgtgattaac attagggagt actgagtgca tcactntatc agtgtgacgg gtgatgtcca 300 cgtcatggct gttctgactc tgaaagccac ttctgctgat gtctaaaccg cactcaccgc 360 ggacgtccgg ggttgtggtg gccctgctgt gcctcctgca ggtgagaggt gtggtgttgc 420 cngttggact tgctgttgag cctggttgca aacctgtagt gana 464 <210> 88 <211> 611 <212> DNA
<2l3> Human <400>

tttgctaaaaatttaccaaaatagtttgaacacataaaaatatttttaaaaaaacagaac60 caaaaacccagcataaatttagttgtataggcattggttagaggacactgttttcactaa120 ggattatattcaacaactttctcttgagttgttactaaaattctgattctgaaccttata180 gcttataatggtgccaactattagaaatgggaaaatctaattcagtccaatgtaacatgt240 attatgatataatagatgaagggtatgtctacactataataaaaaataaacatatttttg300 gttatttaaagaccatcttcctaacctgtaactaaaataactgtatttgatttaaactta360 tttaagtgcagtgaattatggaaagctaacttaaaggtttgaataatcaattatgagtaa420 ggaacacctg ttgacagccc cgtgaccctt cagaaccagg catttgctga aaaaaagaaa 480 tcactagcat tgaatatagc ccttagtcac gtgagagatt aacttcatga gcaacccagc 540 atgtagagga tgaggtggac tttcccagcc acccactcct tgaggggaca gtagtattca 600 tagtgaaact g 611 <210> 89 <211> 515 <2l2> DNA
<213> Human <400> 89 tttaacagta aaatttattt ttatttttgc atattctcaa atacacattt acaatagtat 60 cacacttcct atatgaattc ttcatagtta ttttaagtat tttacaattt gtacagagga 120 agggacatac aatatctaat aggctatttt tcaaccaaat aataatttat gtccttgtaa 180 gattttgtac ctctttaaaa ctttcaactt caacatccac ttttttagct ttgctaatca 240 aattaagaattaaaaccagcctgcaaataataacagtatataacattaagcacaatttca300 tttctttctttatacaaatgttctatatttacttgaccaaatgcttaattaccttttaaa360 ggtttcaataccgtggttaaaaacaaaacaactgtgtatacctccagactatatgaaaaa420 tatgaaatatgtaaagtgtcacgttttttaccttagtttatttttaaaagataaatagct480 aactatctgtattaattttaaagaatgttttaaaa 515 <210> 90 <211> 535 <212> DNA
<213> Human <220>
<221> misc_feature <222> (422)..(422) <223> n is a, c, g, or t <220>
<221> misc_feature <222> (424)..(424) <223> n is a, c, g, or t <400>

gaattctccttaatagttatgtgcaaacaggatgctcgaccctaagtgaattttagtgca 60 gcctcaggccaatcttggtcctgggagtgggcagggttcccagaagaacgagtctggttt 120 ctgaggctgtagaagggagccggaagcccctcaacttgatcacggtgagaacacagggag 180 cctttggagaagctattcagccactgtagttaagagctcctgttctgatccagggagacc 240 tgggttcaagtcctgactcagccacttcctagttgtgtgagtttcagaaaaaaaatcact 300 tcacctcttagaacgcaatttcagcttctgtaacaatctctaggttaggagggagtgggg 360 cgggtgagggcggggaggggagaggaaaaaaaaacacaacaatctctatgtggtttaagg 420 gnangggggttaaatgagatgatcatgacaatgcctatagaagtgctgggagtatgaaag 480 ctggaacagccctgtgagctttgtgtcgttgtccgatttttgataagggcaaata 535 <210> 91 <211> 535 <212> DNA
<213> Human <220>
<221> misc_feature <222> (97) .(97) <223> n is a, c, g, or't <220>
<221> misc_feature <222> (322)..(322) <223> n is a, c, g, or t <400>

tttttttttttttttttacaatttaaacaagaggattcactggtttgaaaaaaaggtttg60 aaaatcaggaaagctaaacaaaagtcattttacatantggagaaactgagacccatatgt120 gtaaatggcttcccaaggtcacagtggtgtcagtggcagagctggtactgtaccaggctg180 cctggatcatagactgatgtttttgccaagaccagccgaaatgttcctctcaggaggtgg240 caggtgggggtggagtgccaggaaggcactgtccaaagaagtgggttaaggtcacagcct300 cccggctccc aaggaccccc tngagaacag ttgctttgga aaggtcactc agatgtgaac 360 cagaggcttg aggttttgga gtggaaaggg gcagggtaag gaagaataga gtaggaggag 420 ggcgggggac agggattcat cctccaggtt cctcacaccc ccactgggag cagcgccccc 480 accccaagca cctgatttca aagtctcccc tccactgaag ggaggggcaa aggga 535 <210> 92 <211> 548 <212> DNA
<213> Human <400>

accttcttaactatgagattattacaaatatatttttacaaatacaaaaaactgaagtac 60 agagaggctaagttaatttctccaaggtcccacagcaagtaactgcagaagggcaaagca 120 aaaataggacaacacatgtaggcaataccaagcagttcttgtggcagcaactggaaacct 180 tttggagacaccattctgcatttcgttgtagtcatacacaaaaccctagttatgtatcca 240 tgcttctttctcataatgccaaagtggcactattctaatttactaacaaggttttctaaa 300 aactacccaaattattgaggtgtttttgctcacttcttcccattagaataaatgtagaca 360 ataagaaacgcatgagggatgacatagtcctccatcaaatctgtcctttcacacaagaga 420 tggcatggtgtagtgtagcagaatcatgagctgccaggaaattatgaattctgattcctc 480 cagctgagtctttgaaaaagtccagatgagaaacacttccatcctgatgctgaagcaagg 540 agaatgtc 548 <210> 93 <211> 481 <212> DNA
<213> Human <400>

tttacattgttattaccactttatttatttcctgatatcgactagataattacatgtccc60 atcactctcccacatgggccatacaatggcttgagctgcatcattttgtaaattcctcaa120 gcttctctactggtacacatattaccctagcctatgtttctgagatgccttagtgaaagt180 tgattttctttctatgtcttctcagggaaaacgacttctgctttcacacttactggagat240 gggagatgagtggcactggcaattcacaccctgaaccttcagcttcacaacaaaatcgtt300 tgtgaggccaaaggaatcaagacagcagagctcaaagcagggccagaaggtgcagggggg360 accacattggcgggtctcgctcagggacacgatggcgtcattgtaacagcactgctccaa420 ggggttgtagatcttgtctccacacctgggtgccggctggcacagccatggttctgagcc480 <2l0> 94 <211> 4021 <212> DNA
<213> Human <400>

taacgaacgtgtgagagatctacttcggcggaagtcatctaaaaccttcaatttgagagt60 ccgtgagcatcccaaagaaggcccttatgttgaggatttatccaaacatttagtacagaa120 ttatggtgacgtagaagaacttatggatgcgggcaatatcaaccggaccaccgcagcgac180 tgggatgaacgacgtcagtagcaggtctcatgccatcttcaccatcaagttcactcaggc240 taaatttgattctgaaatgccatgtgaaaccgtcagtaagatccacttggttgatcttgc300 cggaagtgagcgtgcagatgccaccggagccaccggggttaggctaaaggaagggggaaa360 tattaacaagtcccttgtgactctggggaacgtcatttctgccttagctgatttatctca420 ggatgctgcaaatactcttgcaaagaagaagcaagttttcgtgccttacagggattctgt480 gttgacttggttgttaaaagatagccttggaggaaactctaaaactatcatgattgccac540 catttcacctgctgatgtcaattatggagaaaccctaagtactcttcgctatgcaaatag600 agceaaaaacatcatcaacaagcctaccattaatgaggatgccaacgtcaaacttatccg660 tgagctgcgagctgaaatagccagactgaaaacgctgcttgctcaagggaatcagattgc720 cctcttagactcccccacagctttaagtatggaggaaaaacttcagcagaatgaagcaag780 agttcaagaattgaccaaggaatggacaaataagtggaatgaaacccaaaatattttgaa840 agaacaaactctagccctcaggaaagaagggattggagttgttttggattctgaactgcc900 tcatttgattggcatcgatgatgaccttttgagtactggaatcatcttatatcatttaaa960 ggaaggtcagacatacgttggtagagacgatgcttccacggagcaagatattgttcttca1020 tggccttgacttqgagagtgagcattgcatctttgaaaatatcggggggacagtgactct1080 gatacccctgagtgggtcccagtgctctgtgaatggtgttcagatcgtggaggccacaca1140 tctaaatcaaggtgctgtgattctcttgggaagaaccaatatgtttcgctttaaccatcc1200 aaaggaagccgccaagctcagggagaagaggaagagtggccttctgtcctccttcagctt1260 gtccatgaccgacctctcgaagtcccgtgagaacctgtctgcagtcatgttgtataaccc1320 cggacttgaatttgagaggcaacagcgtgaagaacttgaaaaattagaaagtaaaaggaa1380 actcatagaagaaatggaggaaaagcagaaatcagacaaggctgaactggagcggatgca1440 gcaggaggtg gagacccagc gcaaggagac agaaatcgtg cagctccaga ttcgcaagca 1500 ggaggagagc ctcaaacgcc gcagcttcca catcgagaac aagctaaagg atttacttgc 1560 ggagaaggaaaaatttgaagaggagaggctgagggaacagcaggaaatcgagctgcagaa 1620 gaagagacaagaagaagagacctttctccgcgtccaagaagaactccaacgactcaaaga 1680 actcaacaacaacgagaaggctgagaagtttcagatatttcaagaactggaccagctcca 1790 aaaggaaaaagatgaacagtatgccaagcttgaactggaaaaaaagagactagaggagca 1800 ggagaaggagcaggtcatgctcgtggcccatctggaagagcagctccgagagaagcagga 1860 gatgatccagctcctgcggcgtggggaggtacagtgggtggaagaggagaagagggacct 1920 ggaaggcattcgggaatccctcctgcgggtgaaggaggctcgtgccggaggggatgaaga 1980 tggcgaggagttagaaaaggctcaactgcgtttcttcgaattcaagagaaggcagcttgt 2040 caagctagtgaacttggagaaggacctggttcagcagaaagacatcctgaaaaaagaagt 2100 ccaagaagaacaggagatcctagagtgtttaaaatgtgaacatgacaaagaatctagatt 2160 gttggaaaaacatgatgagagtgtcacagatgtcacggaagtgcctcaagatttcgagaa 2220 aataaagccagtggagtacaggctgcaatataaagaacgccagctacagtacctcctgca 2280 gaatcacttgccaactctgttggaagaaaagcagagagcatttgaaattcttgacagagg 2340 ccctctcagcttagacaacactctttatcaagtagaaaaggaaatggaagaaaaagaaga 2400 acagcttgcacagtaccaggccaatgcaaaccagctgcaaaagctccaagccacctttga 2460 attcactgccaacattgcacgtcaggaggaaaaagtgaggaaaaaggaaaaggagatttt 2520 ggagtccagagagaagcagcagagagaggcgctggagcgggccctggccaggctggagag 2580 gagacattctgcgctgcagaggcactccaccctgggcacggagattgaagagcagaggca 2640 gaaacttgccagtctgaacagtggcagcagagagcagtcagggctccaggctagcctgga 2700 ggctgagcaggaagccctggagaaggaccaggagaggttagaatatgaaatccagcagct 2760 gaaacagaagatttatgaggtcgatggtgttcaaaaagatcatcatgggaccctggaagg 2820 gaaggtggcttcttccagcttgccagtcagtgctgaaaaatcacacctggttcccctcat 2880 ggatgccaggatcaatgcttacattgaagaagaagtccaaagacgccttcaggatttgca 2940 tcgtgtgattagtgaaggctgcagtacatctgcagacacgatgaaggataatgagaaact 3000 tcacaatggcaccattcaacgtaaactaaaatatgagctgtgtcgtgacctcctgtgtgt 3060 cctgatgccagagcctgatgccgctgcctgcgctaatcatcccttgctccagcaagatct 3120 ggttcagctttctcttgattggaaaacagaaatccctgatttagttttgccaaatggagt 3180 tcaggtgtcatccaaattccagactaccttggttgacatgatttactttcttcatggaaa 3240 tatggaagtcaatgtcccttccctggcagaagttcagttactgctctacacaacagtgaa 3300 agtcatgggtgactctggccatgaccagtgccagtcgctagtccttctgaacacccacat3360 tgcactggtgaaggaagactgtgttttttatccacgcattcgatctcgaaacatacctcc3420 tccgggtgcacaatttgatgtgatcaaatgccatgctttaagtgaattcaggtgtgttgt3480 tgttccagaaaagaaaaatgtgtcaacagtagaactagtcttcttacagaaactcaaacc3540 ttcagtgggttccagaaatagtccacctgagcaccttcaggaagccccaaatgtccagtt3600 gttcaccaccccattgtatcttcaaggcagtcagaatgtcgcacctgaggtctggaaact3660 tactttcaattctcaagatgaggctctttggctaatctcacatttgacaagactctaagg3720 aggagacttttaaagatgcactacatgttttttgagatcattaataaaataagcattgtg3780 aaaacagtcaaggcaatatgaatatctccgtgtagctaattgaattggaactggaaaaat3840 gcagacctctaaaattgaaaatgtaactattttaaatatctacaataaaataaaaacagc3900 taatagcagagccccaatgaaatatctttatcatcaccttgcttcattttcttgaaactc3960 aggcttgtaaatttgtgcctgcttcattatttgtgaggtgattaaagcatttctgattgt4020 t 4021 <210>

<211>

<212>
DNA

<213>
Human <400>

tgtcagtaccacacctgttacgaggtttcctgagagtagcaccccttccataccatctgt60 ttacaccagcatgtctatgaccactgcctctgaaggcagttcatctcctacaactcttga120 aggcaccaccaccatgcctatgtcaactacgagtgaaagaagcactttattgacaactgt180 cctcatcagccctatatctgtgatgagtccttctgaggccagcacactttcaacacctcc240 tggtgataccagcacacctttgctcacctctaccaaagccggttcattctccatacctgc300 tgaagtcactaccatacgtatttcaattaccagtgaaagaagcactccattaacaactct360 ccttgtcagcaccacacttccaactagctttcctggggccagcatagcttcgacacctcc420 tcttgacacaagcacaacttttaccccttctactgacactgcctcaactcccacaattcc480 tgtagccaccaccatatctgtatcagtgatcacagaaggaagcacacctgggacaaccat540 ttttattcccagcactcctgtcaccagttctactggtgatgtctttcctgcaacaactgg600 tgctgtatctacccctgtgataacttccactgaactaaacacaccatcaacctccagtag660 tagtaccaccacatctttttcaactactaaggaatttacaacacccgcaatgactactgc720 agctcccctcacatatgtgaccatgtctactgcccccagcacacccagaacaaccagcag780 aggctgcact acttctgcat caacgctttc tgcaaccagt acacctcaca cctctacttc 840 tgtcaccacc cgtcctgtga ccccttcatc agaatccagc aggccgtcaa caattacttc 900 tcacaccatcccacctacatttcctcctgctcactccagtacacctccaacaacctctgc960 ctcctccacgactgtgaaccctgaggctgtcaccaccatgaccaccaggacaaaacccag1020 cacacggaccacttccttccccacggtgaccaccaccgctgtccccacgaatactacaat1080 taagagcaaccccacctcaactcctactgtgccaagaaccacaacatgctttggagatgg1140 gtgccagaatacggcctctcgctgcaagaatggaggcacctgggatgggctcaagtgcca1200 gtgtcccaacctctattatggggagttgtgtgaggaggtggtcagcagcattgacatagg1260 gccaccggagactatctctgcccaaatggaactgactgtgacagtgaccagtgtgaagtt1320 caccgaagagctaaaaaaccactcttcccaggaattccaggagttcaaacagacattcac1380 ggaacagatgaatattgtgtattccgggatccctgagtatgtcggggtgaacatcacaaa1440 gctacgtcttggcagtgtggtggtggagcatgacgtcctcctaagaaccaagtacacacc1500 agaatacaagacagtattggacaatgccaccgaagtagtgaaagggaaaatcacaaaagt1560 gaccacacagcaaataatgattaatgatatttgctcagacatgatgtgtttcaacaccac1620 tggcacccaagtgcaaaacattacggtgacccagtacgaccctgaagaggactgccggaa1680 gatggccaaggaatatggagactacttcgtagtggagtaccgggaccagaagccatactg1740 catcagcccctgtgagcctggcttcagtgtctccaagaactgtagcctcggcaagtgcca1800 gatgtctctaagtggacctcagtgcctctgcgtgaccacggaaactcactggtacagtgg1860 ggagacctgtaaccagggcacccagaagagtctggtgtacggcctcgtgggggcaggggt1920 cgtgctgatgctgatcatcctggtagctctcctgatgctcgttttccgctccaagagaga1980 ggtgaaacggcaaaagtacagattgtctcagttatacaagtggcaagaagaggacagtgg2040 accagctcctgggaccttccaaaacattggctttgacatctgccaagatgatgattccat2100 ccacctggagtccatctatagtaatttccagccctccttgagacacatagaccctgaaac2160 aaagatccgaattcagaggcctcaggtaatgacgacatcattttaaggcatggagctgag2220 aagtctgggagtgaggagatcccagtccggctaagcttggtggagcattttcccattgag2280 agccttccatgggaactcaatgttcccattgtaagtacaggaaacaagccccgtacttac2340 caaggagaaa gaggagagac agcagtgctg ggagattctc aaatagaaac ccgtggacgc 2400 tccaatgggc ttgtcatgat atcaggctag gctttcctgc tcatttttca aagacgctcc 2460 agatttgagg gtactctgac tgtaacatct atcaccccat tgatcgccag gattgatttg 2520 gttgatctgg ctgagcaggc gggtgtcccc gtcctccctc actgccccat atgtgtccct 2580 cctaaagctg catgctcagt tgaagaggac gagaggacga ccttctctga tagaggagga 2640 ccacgcttca gtcaaaggca tacaagtatc tatctggact tccctgctgg cacttccaaa 2700 caagctcaga gatgttcctc ccctcatctg cccgggttca gtaccatgga cagcgccctc 2760 gacccgctgt ttacaaccat gaccccttgg acactggact gcatgcactt tacatatcac 2820 aaaatgctct cataagaatt attgcatacc atcttcatga aaaacacctg tatttaaata 2880 tagggcattt accttttggt aaagaaaaaa aaaaaaa 2917 <210> 96 <2l1> 138251 <212> DI~7A
<213> Human <400>

gatcaaaagatgctcatcaaaagctctgagctttcctgagtgctaacaggaaacatccag60 catcactggtctctccaaggctgcaggtgtctttgcccatagtgcctgttttgtgtcagg120 gaaagaatcaacctgggagccaagcccaggaatcaggatgaccaagacatactggacaag180 gaaggaacaaacccatccaaggacactcaaggacaaatcaagcaaatgaatttaagggag240 acctgctcatggtctgctttgctgctcagcatggctgggaggcacagtggaagatcatgc300 atccttcccctgggactcctctgccagagcctgagagctttctcctgcacacaggctagg360 ggtagggcagttggaattgatccatgccttctagctagactgtgggtcccctcagtcttg420 ggcatggtgacagcccagcatcagacagaggtcagtatcaaactagaaaatttaataaat480 gctgtcagatttgtagacccaagaaaatataaactgccaatcacggaggaaaaaaatctc540 tcaatgatcttatctttatatgattcccttgctgcctggagattgacatttccttgggga600 taatctggtcataggattggtgaaggtggaagggaggcaacctccgaaggtggggccctc660 tgctcacctgggacagggggggcctgaggtaggtgtctgtgtgggctgggcaggaggatg720 ggagcagtgcttctagatgtttccactttctcctcattagataataatgaatgggtgatt780 tccctagtcactgcagtgtgaggaaatctacaaaattaatttcacaatacactttacagg840 ataggtggagaaacacatgaagcacaactgcagtgggttataaaaaatggcctttcgagt900 tgagcagtaaattcgttcaagcagccattctgaaggacaaactggctctgtatttaacag960 gggcattccagcacttctctagctactgggttgacaatgactcaccaaagcctctggtag1020 ccaccacaggacgcccagagcacgttttaaagctgaacaccaaactgcggacttcgggag1080 taagtgaactgactggtttttattttgttttactgcttttaacattacagtgactgttac1140 aggttccagcaggataactgggtggaaatgagtttggtttcacttagtctctctaaagag1200 aaagcaagttggtagactaatacctaataaaagcaaagctgccaacaattgaaattgcct1260 gggctgctctgtgtgtcccacatgcatgggtgtgggtgccagtgtgtgtgcgtgtgtgca1320 tgcatgtgcatgtgtgttgggatagagtggcaagaaaatgggaaataataagaatgttca1380 gtccatagcccttcattataaaaaggtgagctgtaataaatactagtgccacatttagcc1440 aaaactttactccagccaaaggtgatattttcatgataacatcctgtgattgctttgttc1500 ttcgtcttttatgttcttcctagatgggctcagaacatacaagaattaagtacacatctt1560 attttccagtgataatgctaccggcaaattctgttgtttgtataaacatcagccatgttt1620 atataactaaactagtgttttgttttgtcaattcagcaagaaattagaccacatggtggc1680 ttaatgctgcattgatttggctatcaatttgttttcacttttctgcaaaatatttaatac1740 attattaaattgaattatgctgatgccacagttgttcttatctcaattgtcttaaaattc1800 atttaatttttttttcctttcgtttcattattcaaattttaacttcagttctcaacattt1860 tatctgatggaagagatggagtccattactaaggactccattgtgctccatcatgccaga1920 gttgtaaaatagatcttttaaaggaaatttactgtgatttttttctatttaagagcttcc1980 tctccagttgagcatgtaagaaaattataccaggagaatacagtaaactctatgaggcaa2040 gctataaacatgtaggattgtgattagggctggttctccttctagagacatggtaggatt2100 gcaatttcataccatccttgaagttagagagagccacttgactcatttagccaatgaact2160 gtgagcagaatgacatgtcacttccagcagaagctttaagaatctgagagacattcatac2220 gttttccatgtgctgtagccttatacccaaagcctgggtcccaagtgaccatgacaggca2280 gagctccctgttgagccacagagatttagagaatggctgttaacacagcataatccagcc2340 catcctgactaatctgatattaacatgtataataaagaattctatcaatgctgagggaag2400 atgattagttaaggtcctaggttgcaagtctcaaaacctcttctaaggattgtagacagg2460 aaattaaatgacttctagtccctagagttcccaatctcctaccatcccatcctaatatga2520 cagaagtaattcctgagttgcttctgaaaccagagcttccctcagaacccttagcctgcc2580 agatggcttcttggagagccctcactcacttttctccttctgctattgctgctcattcat2640 tccagcttttaaaaattcatctttatccaggaacctcgcttctagaaaagtcatacaggt2700 gcttccaggaggctacatgggcacccatatttttctagccactttcattagaccaatgca2760 gcagagaagaaaagcctcaataattattatgacatggcatgttaggataccaagtaaatt2820 gcatttgtaaaatgtgattttctgttggtgttcacttcggctctactgacatttggtaag2880 tattattgactgactgactaactaatgtggtcattagtcttcataaagaaaggctctcta2940 caaaaacggagggatgccctttttctggcatttaatacgtaagaaattgcctccgataga3000 aaccagagttgcctgattactatcagcacaggagaaatgtattaatgtgcctttctagta3060 acaggtttttagaaagtcaaatataaacaaatctgtctatttgtgtgtgtgcatgtggta3120 gtggggagggaagaaaaaaggagggggagagaaagagaaataagaaccaagtttattata3180 ctgtattcagggggaaaacattttcccaaggttctaacagaagagcaaagtgccactgtc3240 aatagcctcagtagtgttagggttgcttttatgtatttatttatttacttatttatttat3300 ttttcctttttttttcctttctctttttttcttcttttttttttttttggacagagtctc3360 acactgtcgcctgggctggagtgcattggcgcaatcttgactcactgcaacttctgcctc3420 ccaggttcaagtgattctcctgcctcagccgcccaagtagctgggattacaggtgtctgc3480 caccgtgcctagataatttttttatatttttagtagagatgaggtttcactatgttggcc3540 acgctggtctcaaactcctgacctcatgatccacccacgttggcctcccaaagtgctggg3600 attacaggcgtgagccaccgcccctggccaggattgcttttatagccagtcttcaggtgc3660 ccactgtaggaacaatgtcatttagccctcgggattattctgtgccaaatatggataatg3720 actaatattcaacacagatattctcagctcagaagagcaattagcaaattcataaattaa3780 gtgcttgcttcctttttagtcaaatacaaacatttgttaaaagatattattttgctttac3840 actttttctctcagaaataaacagatgcttgaattcccacagtgctgcttgagcctcaca3900 ccatgtcatcctgccaggcacccagatccagttctagagtttcacatgatcatgagtgtt3960 ggttaataagtcactgtgaactgggaggggagatttttcaggagtgccacagggctctcc4020 ctttaatcacatacactccctgctttcattggaaagtgtataatgatgtcagagtgcccc4080 agaatggagctagttggaagactgccgtcatagggatgccttagtgaattaatcaggttt4140 taatttctggctctcaactttgtagatgtaaaagttgatttatcaatatgtgagaaagga4200 tgaatctttctgaaggttatgtcatcacactcactaagcacacagagaataatgtctaga4260 atctgagtgccatgttatcaaattatactgagactcttgcagtcacacgggctgacatgt4320 aagcatcgcctgcctagtacagactctccctgcagatgaaattatatgggatgctaaatt4380 ataatcagaacaatgtttggtgagccaaaactacaacaagggaagctaattggatgaatt4440 tataaaaatatacctcagccaaaatagcttaattcagtctcccttatcataaggatactc4500 ttgcctaaag ggacagtaat attaaagaca ctaggaataa cctctgtact ttggacagta 4560 gacctgcata gcccattagg cctcaatgaa gtcttatgca agaccagaag ccaatttgcc 4620 attttaaggt gattctccat gtttctgctc taactgtgct tcacaatact caagacactg 4680 aatcaggatg tttcctggag tgcagggagc tgtccgtgtt actgagcagt tctcagcaac 4740 acaaagatcctactgactcctcatcagacttctttctcactggaattttacacctgggct4800 gttaacaccaggccaggtcaaattcaaaggagagaaaaaagctcattatgaagggtaaaa4860 tccaaaacactgtgcataaagatatgtgtgcacaatttttatacataaagatttcataaa4920 gccaaagcatcaggaaatgaaaagagatacagaaagaaaaatgatggtaaatgagacatt4980 aatttacccttctaatctctatcacagcaaaaaggtaattaaaaaatctatatgaggacc5040 aaaaaatacacaaagactatgtagcaaagcctatagcctgaaaaagtaaacattgaaatt5100 tgtatgtccataaaatgtttacaaaattcagtacatattacacaccccaccctaaaaaca5160 tctaagcaaa gtagagaatg tagaaatgct acagattata ttctctgatt atgacacaac 5220 aaaactagaa attacagcat ggaaatttaa aagctttctc ttaaataatt ctatgtcaaa 5280 aagaaatccaggccgggtacagtggctcatgcctgtaattccagtactttgggaggccaa5340 ggtgggcaggtcacttgaggtcaggagttcaagaccagcctcgtcaacatggcgacaccc5400 tgtctctactaaaaatacaaaaattagctgggcctggtggcgcatgcctgtaatcccagc5460 tacttaggaggctgaggcaggagaattccttgaacccagaaggtggaggttgcagtgagc5520 tgagattgcaccactgcactccagcctaggtgacacagcaagactctgtcaaaaaaaaaa5580 aaaaaagaaatccaaataaaatttccagaatatgtggaaaatagtgccaataaaaatatt5640 acacatgtgtaatcccagcattttgagatgccaaggtggcaggatcacttgagaccagga5700 gttcgcaaccagcctggacaacatagggagactccatctccacacacgccaaaaaaaaat5760 tttaaatagccaggtatagtggtacttcttgtaatcccatctacttgggaggctaaggtg5820 ggagaatcacccaacctcaggagttcagggcttcagcaagccatgatcatatcactgcac5880 tccagcctcagcaacagagcaagatcctatctcaaaaaaaaaaaaaaaatcacatgtggg5940 aaatagctatagcacaataaaaataaatgtattaagtatgaacaacaaaaaagctagtaa6000 aggttgaacaacaactatccttaggaaagtggaaataatgtgttaataaatatgaaagca6060 ggctaggcacggtgactcacatctgtaatcccagcactttgggaggctgaggcaggcaga6120 tcacctgaggtcaggagttccagaccagcctggccaacatggtgaaatcttgtctctcct6180 acaaatacaaaaactagccaggcttggttgcgcactcctgtaattccagctacttgggag6240 gctgaggcaggagaatctcttgaacctgagaggcagaggttgcagtgagccaagatcatg6300 ccactgcactccaactggggcaacagagtgacactccatctcaaaataaataaataagaa6360 agcagaaactaataaattagaaaacagaaacatagaactaatttataaatcaaagcacta6420 tgccttgaaaagagggagaaaaattgtgaattaaggaagggaagagatggttggagagga6480 ggtgggagaaggcagagataattgaaggagcaaaagcatctggagaagcaaagccactga6540 aagatgaacagggctctgaaagaaatgcttgattgctatcttttcaaatgactgcagttc6600 ccagtgacatcatttttctcctccctggaagtctgaggggcagttcacttatctactccc6660 CtCCCCtaCtcctcaccccacactcaaaacctgtctatgctcctttcattctcatatgac6720 agatttcagatggcattcttatttccctgatttctttttgagatagcttgcatttcccta6780 ctctatataaagccaccgtttatcaaatgcctacatggaccaagcagtccacaagggctt6840 cacagacagttttactaaactcatgccaaaactttcaggttttatagataaagatctata6900 ccttatagataaaggtatctataaggtatagataaaggtaaggtatctataccttataga6960 taaagaaattgaagcttatagagtttaagtaatgttcccaaagcctcgtggctagtaatt7020 caaacctaatttctgcctactccaaagtctatttttcctcatgatactatactgcctctc7080 catggataaagacagagatcacatattaataaaatttgcacaaagtcggcaaattgttga7140 aagggaaggctaagatgactaataaaatcaagagccagatgatctcaacaacctgaaata7200 actggctgacaaccaatttgaataactccctgcgggtgaagttcaaagtactatttgggg7260 tttttttttaagtttggctgggtgcagcggctcacgcctgtaatccaagcacttagggaa7320 gccaaggtgggtggatcatgaagtcaggagttgaagaccagcccggtcaacatggtgaaa7380 ccccatctctactaaaaataaaaaattagccgggcctgctggtggatgcctgtagtccca7440 gctacgcgggaggctaaggcaggagaatcgcttgaacccaggaggtggaggttgcaggga7500 gccgagatcgcaccactgcactccagcctgggtgacagggcgagattccgtctcaaaaaa7560 taaaataaaataaaataaaaaataaaagtttgatatattcagaatcagggaggtctgttg7620 ggtgcagttcatttgaaaaattcctcagcattttagtgatctgtatggtccctctatccg7680 tcagggtcctagcaggaaattgttgcactctcaaaggattaagcagaaagagtttaatga7740 agggtctctttccagggttaagggaactgctagggtttggatatttgaccactccaaact7800 catgttgaaatgtgatccccattgttggaggtgggacctaatgggaggtgttttggtcct7860 gagtgtggacctctcacgaatgtcttggtgccatccaagtgagatcttgctcgctctttt7920 tttctttttgagatgtagtttcactcttgctgcccaggttggaatgtagtggtgcgatct7980 tggctcactgcaacatccacctcacgggttcaacccattctcctgtgtcagcctccagag8040 tagctaggattacaggtacccaccactatgcccagctaatttttggtatttttagtagag8100 acggggtttcaccatgttggccaggctggtctcaaactcctgacctcaggtgatccacct8160 gcctcggcctcccaaagtgctgggattacaggcgtaagccaccgtgcctacctagttcta8220 gctctcttaattcccacaagagctggttgttaacaagagcctggtacaaacccctctctc8280 ttgccacgtg atctctgcac atgccagctt cccttcccct tctgccatga gtggaaacag 8340 actaaagccc tcaccagaag caaatggtgg caccatcctt cttgcacacc ttcagaactg 8400 tgaaccaaat aaacctctct tctttaaaat tattcagcct ctggtattcc tttataacaa 8460 cacacacaca cacacacaca cacacacaca cacgcaaaag cagactaaaa caggaactaa 8520 ttagaaatgg tgatgcaccg agggattggc accgaggctc cccaacagga actgaggcca 8580 tggatagaag gacacattca tgttattttt ttctaatggt taagtaatta tttgctctta 8640 ctctcaaaat ttctgccaag gcctcccatg gaccaaactc aactagaatc taggaagcag 8700 agaacctgag tgttgcattc agcagaagtc agcttcctag ggaatattgc aggaagggtg 8760 aaggtagaga atctggtggg gaagcaagca aatgcccatc acatgcactt tcctccaaca 8820 gagcgactca gatgctataa aacttgctaa cgcagtctca gggtctgatc acagtaacat 8880 acaatccagg ttttaatcat cagaaatcgc agtcctattg tcttctgcac agacccaaac 8940 acacttggag gtcatgttca atatgaatac ctcacagaga aggaaattta cacacgagaa 9000 gtacatctgc agaaagccag ctggcatgtc aaccattcga aaactcagga tgttcgggat 9060 aaagaagact caggaagaca agtatgaagc ataatctgtg acattattga tatcttcctg 9120 atatcaataa tattgatatc ttcctgatat caatattatt gatatcttcc tgaagaacat 9180 , aattcctgcc taccatcaac aagcatcaat actttctacc agctattctc aaccctcatc 9240 atcggaagag acagacactg actgtgtcaa agtattagtc ccatcattca gcaattaact 9300 ttagctcaat gcttcaaaaa ttcttcaggc cctgtgtaat ttcagctatg tacattaatg 9360 atgagtaccc atacaaccat tctgtttctt attttcagta ccatatttaa taaatatcag 9420 ttattcaata ctttatttag acattttgtt agattgtttt gaccaatgaa gtctaatcta 9480 aatgttctga gcatgttcaa agtaagctag gctaacctat aatttttggt gtgctaaatg 9540 catttttaac ttatgatatt ttcagtttac gggggtttgt tgggacataa cttcatcata 9600 catcaaggag catctgtata tgggatatag ttaaagcagt gatcagagga aaatctatag 9660 ccttaacaca tttattaata aaagtgtagg aattaaatta tcagctgaaa aatgtaaaaa 9720 gtatctaaaa gagtaagcag aaagtacaag aaagaaccca tagtagaaaa aagtgaaaat 9780 taataaaata agaagccaaa aaacagatca aatcagtaaa ccaaaaatct tgttctttaa 9840 acaaatcaac aaagttgaca aaaaattaga tcttttaatc atgaataaaa aaagagaaag 9900 cacaaaaatg aataaggaat ggtgagagaa ataactattg ataatcagca aataaaaaat 9960 cattaaaaac aatgttgttc acatctatga aaaacattga aagctagagg gaatgggtaa 10020 ttttccagaa aaatacaatt caccacaatt gacttcaaaa aaaaaaaaaa agaagtacag 10080 cacttatgtg agcaatttcc atagagaaat acagttgtca tggaattata acacacacac 10140 aaacactagg tttagatgtt ttcacagaga attccaccaa acctttagaa atcagatcat 10200 ccaaaggcaa attaacaacc ctcagccatt tgaggcaaaa tattacaatt gaggcaagat 10260 atactgtact gaaaacttga ggaaaaagca ggagagaaag ttcctttggg aaattcgaat 10320 actcaaaagt gcttacatac aatgaaaaat ttggaaatcc ataagcatgg ccaaggtggg 10380 acacatgctc agaaaaggcc tgagaagaca ctaataactc acctttagta attcctaggc 10440 tcacagcaag aaaaaatgaa ggctaaggca gaattatata tggctccact aagtgttgag 10500 ggagccccaa tacagagtca gtaagcaaag tctgggagat gtttttcata tttttttctt 10560 ttttggctcc ttgcagtcaa ggaaatcatt tttaaatcac taaatgctaa atgaacacaa 10620 gctaaaggaa ccgagccgcc ttcaaacatc aaacataaaa aagaatgcag atattacaaa 10680 accagtttac aaaagttact aaacaaataa aaactacatc ccacagtggg taacaaaaat 10740 aaccttgaag aagggaaaaa tttggtttcc agaataaaca cattataata tccaaaatgc 10800 ccagttttca acaaaaatta agaagcatgc aaataaacac aaaactatgg cccatttaca 10860 gaagaaataa atgagactct ccctgagtaa gcagatattg gaaatattcg acaaaaactt 10920 tatataactg tcttaaataa acttaaagag ctaaagaaac ccaagagaat gacatataaa 10980 taaataagaa atatgaattt tttaaaaggt acaaaaaaat tctgaggctg aaaagtacaa 11040 taactaatta aaaagttact ttttacttag ggttccaata gaagatttga gcagctggaa 11100 aaaagaatca gtgaacttga tagatcaagt gaaatgattc agtctgaaga gcaggaaaat 11160 gaaagaatga caacaaaaaa gaatagagcc taaagacctg tgtaacaaca tcaagaatgc 11220 ctacatacag aatcctggtg gggagtgagg ggcaggaaga ctatttgaag aaatgtgttt 11280 gaaagcttcc caaatttcac taaaaacaaa tatatacatt caaaaagctc agtgcacttc 11340 atcaaggaaa tatacaaaga tattcacacc aagacacact atgtttcaaa ttgtcaaaag 11400 gcaaagcgaa tgtttgaaag cagcaagaga aaggcaacgc gtcatttaca aaggatcctc 11460 aataagtttg acagcagata gtgcattata atccatggat gccagaagag cttaggaaaa 11520 aggcaatgca tcatttacaa aggatcctca gtaagtttga cagcagagag ctcattataa 11580 accatgggtg ccagaagagc ttagaatgac attttaaagt tctgaaagaa aaaaacactg 11640 tcaaccaaaa attctgtaac ttggaagatg ccccttcaag tattaaggat aaattacaca 11700 ttcccagatt aaaaaaaaaa gagagagaga aagagaaaga aagaaagaag agagagaaag 11760 aaagggagag aaagaaaaag aaagaaagaa agaaagaaaa agaaagaaag aaagaaagaa 11820 agaaagaaag aaagaaagaa aaagaaagaa aagaaagaaa gaaaagcaag caagctttaa 11880 aagttcatgt ttggtaggct gtacttcaag atacactttt aaaaaaaaag actccttcag 11940 atacaaacta aaaaacacta gaaagtaact caaaaccaca taaagaaata actccagtaa 12000 ggataactac ataggtaaat ataaaagcaa ttatcatatt ttttgtaagt ctttttaaat 12060 attctatatg ttttaaaaca aatgtgtaaa ataatgacta taaatctatg ttaatgaagc 12120 atgatgtata aagatgtggt ttgtgaaatt accaacataa agaaattcat aggaaactaa 12180 ataataatag agattttgta tactattgaa gttgtttcaa tttattctaa attgttccaa 12240 attaagaatg ttaattgtaa atccccatgg taaccactaa gttaatatct tttgaaaata 12300 cagaaaagga aagcagaggg taaacacagt gatatgctac aaaatagcaa ctaaacacaa 12360 aagaaggcga taattgagga aattaggaac aaaggaggta taagacatac agaaaacaaa 12420 agcaaaatgg taggagtaag cccctcttta tcagtaatta cattaaatac aaatgaatta 12480 aactctccaa tccaaagaaa cagattgaca gaatggattt ttaaaaaatg atccaactat 12540 attgtccacc agatactcac tttagatcaa aatacacaat gagttgaaat gaaaggatgg 12600 gagaaaatat tccatgtaag taataaccaa aggagatctg aggcaaatat acttatatca 12660 gacaaaatag actttaagtc aaaaactgtt acaaaataca aagaacagta tatattgatt 12720 tcaaaattaa acaagaagat ataacaatta taaatatatg tacaccaact aacagggctc 12780 caaaatatat aatgtaacca ttgagagaat taaagggaga gacagacaat tccacgaaaa 12840 ttgttgggca ttttaaaacc caactttaat aaaggacaaa acatccagag caaatatcaa 12900 gggaggaatt agaggatttg aataaaacta taagcaataa ctatagataa cacttctctc 12960 aaaaactgca gaatacacat tcttctcaag tgaacatgga acattctcca gcacagatga 13020 tatgttaggc cataagataa gctcaataaa cttaaaaaga ttgaaatcat gcaaagtatc 13080 ttcactgacc acaatggaat gaaataagat atcaataaca aaaggaaaac tagaaaattt 13140 acaaatattt ggaaattaaa caacacagta tttaccaacc aatgaatcaa agaacaaatc 13200 atgagggaaa ttagaaaatg tttagagacg attgaaaaca aagatataac aagatgggtg 13260 tgatatatca aaagcagtgc tcagagttgt aacacctaca ttttaaaaaa gaaacatgtc 13320 aaatcaataa ccaaacttta ctcaataaat cataaaagga agagcaaaca aaatccagag 13380 ctagcagaag gaaggaaata aagattagag cagagataaa tgaaattgag aattaaaaaa 13440 ttatacagag atcaacaaaa ctaaaagttg gttcttttaa aatatcaata aaattaatat 13500 acttttacat agactaagca aaacatctct attcagctga cttttttttt tacaagggag 13560 ccaacattat tcagtgggga ataatagctt tttcaacaaa aagtgctggg aatactgaat 13620 attcatatgc aaaaaaaatg aagctggacc cctacctcac attatataca aaatctagat 13680 tggatcaata atgtaaatat acgagtgaaa accatacatg cttagaagaa aacatggaaa 13740 taaaacattg ctgtggattg gcaatgcatt cttagataat acaccaaaaa tacaagcatg 13800 aaacaaacaa atgtagccaa aatgtaccag aatctgaaaa catgtattat ctataaagaa 13860 ttagagggga atttggtgaa agaaatatgg gagaatggga tattgctctg tgaatgcttt 13920 tgtgcataat tgtacatttt taattaagtt aatcttttac actctcaaag tgtgatatta 13980 agcaagcaaa gataagttat tacaagactc taaaaccgaa tgcaatgaga aacaagtgaa 14040 tccaaatata tttcaaatga atgaatgaca taatcaaact taaggggaaa ataataatta 14100 atctgattaa tttttgactg ttctcttatt tcaaattgac ttttgaacat actttgacta 14160 catactattg cttgaaaaaa taaaatatct gcaaaaaatt attaaatctt catgatagga 14220 ttttttcttt ttatattagt ataaatataa caattctgaa acaaatgtat gtgcattgta 14280 agattaagcc aatgagtaaa tattaatata tttgtattgc tagaacccca gattctcact 14340 gtgaaaggac agagatacag atatggaata agacaaggaa agaagcagcc cactgagtta 14400 cattagaatc agtattatca acataaataa gcaatgtgct ctctcacatg ctctttcctt 14460 ctcttaaaaa atatataata tgtacttatt atatattata tgcatagaca cacgtgtgtc 14520 tatacatatc ctacatgtac atattgagga ttaacaggtg ctagtagaaa atattaactt 14580 tctttgtatt aacaggtgtt agtagaaagt agtagtaggt gctaagataa aagccataat 14640 taaacctcct ggtgaatgaa cacaccatca cctacaatct taccaaaaat agaatcaagc 14700 acgtgtccta gtcaaacctc tggattcaac tgtcatttgg ataaaacgca aaggatagtg 14760 aaaatgtcga tcttcactga gagtctcacc agcaaaattc acagtgtgga caccaagtga 14820 caaaaatccc aaatttttca acaaatatat tgtatgggaa agaaaacttt gaaaagaaac 14880 ctgtatgtta gaaggcattt taaaaacacg acaaatgaaa acaaatgggc aagactaaat 14940 catagtgtct tggaatgcat gcatgaagga cacagccgtg aaaatgcaag gacgcctcta 15000 ctggaacagt catgtttatc gtcacttttc aggagaaagg tggctgcagt tgaggagagt 15060 cacatgcttc agggctggca aagtcctata tcttgactta tgtgatgatt acagggatgt 15120 ttacaaaaat caaactataa gtttgttttg tgccatgttt tgtattgtgt gtgtgtgtgt 15180 tttgtttttc aacttaaaaa taaataaaat caaaaccaag gcttcattat caagtagcac 15240 aaagtctcca atctataacc tcctttgtct ggatatctgc atttaactac cattgccaga 15300 gctaatcctg acaatgcatt catattttta acactgaaac acagtaaaca gggaaaattt 15360 tgctcctcta aaacagggca tcttcaggca atcagaacaa ctcagaaagt ttctgtctgt 15420 tgcataaaac tcccctgtgc aaagagttac acaaaatgct gtcatagtaa aggtagttaa 15480 ctaacggcac taattgttct tgggcagtgg ccaagtggaa cttcagagac ctggcattgc 15540 caaccagaaa tcaattgtca tgggaattgt ctcctggaat cactttggtt gtcccagggt 15600 aacgcaggga aagtggttaa tgggtcactt cggggtggca tcttcatcag taaatcacat 15660 ttactttctc ctactaagaa ttttattttt ggccatgaag ccaaaagtca gctcttaaat 15720 aacaagggaa gcaaataatc attgaataaa aatagcagaa agaaaaagct gtgcaaagaa 15780 atttatgttt ttaatttgtt atatatgtat atttttatca tactttaagt tctagggtac 15840 atgtgcacaa tgtgcaggaa taaaatttat gtttttaaaa tttattctac attatgaatt 15900 ctacattaga aaaataaacc atagcctcat cacaggcact taaatacact gaagctgcca 15960 aaacaatcta tcgttttgcc tacgtactta tcaacttcct catagcaaac tgggagaaaa 16020 aagcaatgga atgaataaaa tgatagccac aaaaatcaag gtgggagaaa tacttattat 16080 atgtccataa aaaattttaa ttaatgcaaa gtattaacat caatgattgc agtaatacag 16140 atcttacaaa tgatagtttt agtctgaaca ggactatcca aaagttaatt ttctatagta 16200 acagttttta aataaaatat caattcctga aacacataaa atggtccatg agtatacaac 16260 gagtgaaaaa aaacaaattc agagcaaaga taaattaaga agtatctaat attcaaacat 16320 agtcaaagag agggagattt ctggataatc acttaaaccc atggttaaac ataaatgcac 16380 atatgttaat gtttactgaa taacttatct gtgccaagtg gtgtattaat gattcatttt 16440 tatttttcac taaatctttt ctctaaagtt ggtgtagcct gcaactaaat gcaagaaatc 16500 tgacctagga cctgcacttc ttaccatttt gctcatattt attccctgtg catttttgta 16560 acatgtatat gttatatata tagaaagaga gagaggcaga gatggaaagt aatttatgga 16620 gtttgatgtt atgtcagggt aattacatga ttatataatt aacaggtttc tttttaaatc 16680 agctatatca atagaaaaat aaatgtagga atcaagagac tcattctgtc catctgtgat 16740 agttccatca tgatactgca ttgtcaagtc attgctccaa aaatatggtt tagctcaaca 16800 ctgagtgact ataggaaacc agaaaccagg ctgggcgcta aagatgcaaa gatgaatgag 16860 acatcatctc tgccgtccaa aagcttactg tctagtggga gagttacaca cgtaaggaca 16920 gtaatctaat aagagctaat aagtgaaaac taagataaat taataataca agattacagg 16980 gaaggtttcc aaagtcaatg aggcctcaaa tgaatcttga aagtgtgcaa ggattaacca 17040 aatgaagaaa tgtgtaagtt tttcaaacaa aaaggaacag catgagcaaa tgcaaggagg 17100 DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

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Claims (4)

1. A method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises:
(a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 4;
(b) exposing the mammal to the EGFR modulator;
(c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer.

2. The method of claim 1 wherein the at least one biomarker is selected from the biomarkers of Table 5.

3. The method of claim 1 wherein the method is an in vitro method, and wherein the at least one biomarker is measured in at least one mammalian biological sample from the mammal.

4. A method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises:
(a) exposing the mammal to the EGFR modulator;
(b) following the exposing of step (a), measuring in the mammal the level of the at least one biomarker selected from the biomarkers of Table 4, wherein a difference in the level of the at least one biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said EGFR modulator, indicates that the mammal will respond therapeutically to said method of treating cancer.