CA2352592A1 - Quinazolinone compounds - Google Patents
Quinazolinone compounds Download PDFInfo
- Publication number
- CA2352592A1 CA2352592A1 CA002352592A CA2352592A CA2352592A1 CA 2352592 A1 CA2352592 A1 CA 2352592A1 CA 002352592 A CA002352592 A CA 002352592A CA 2352592 A CA2352592 A CA 2352592A CA 2352592 A1 CA2352592 A1 CA 2352592A1
- Authority
- CA
- Canada
- Prior art keywords
- compounds
- aralkyl
- benzyl
- phenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
A range of quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC
2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed comprise certain quinazolinone compounds having the general structural formula II
or pharmaceutically acceptable salt thereof, characterised in that X' represents hydroxyl, alkyl, alkoxy or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g. benzyl) group, and Y' represents hydrogen, alkyl or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g.
benzyl) group.
2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed comprise certain quinazolinone compounds having the general structural formula II
or pharmaceutically acceptable salt thereof, characterised in that X' represents hydroxyl, alkyl, alkoxy or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g. benzyl) group, and Y' represents hydrogen, alkyl or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g.
benzyl) group.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9404485A GB9404485D0 (en) | 1994-03-09 | 1994-03-09 | Benzamide analogues |
GB9404485.6 | 1994-03-09 | ||
CA002184747A CA2184747C (en) | 1994-03-09 | 1995-03-09 | Benzamide analogs, useful as parp (adp-ribosyltransferase, adprt) dna repair enzyme inhibitors |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002184747A Division CA2184747C (en) | 1994-03-09 | 1995-03-09 | Benzamide analogs, useful as parp (adp-ribosyltransferase, adprt) dna repair enzyme inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2352592A1 true CA2352592A1 (en) | 1995-09-14 |
CA2352592C CA2352592C (en) | 2006-06-06 |
Family
ID=25678653
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002350941A Abandoned CA2350941A1 (en) | 1994-03-09 | 1995-03-09 | Benzamide analogues as parp dna repair enzyme inhibitors |
CA002352592A Expired - Fee Related CA2352592C (en) | 1994-03-09 | 1995-03-09 | Quinazolinone compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002350941A Abandoned CA2350941A1 (en) | 1994-03-09 | 1995-03-09 | Benzamide analogues as parp dna repair enzyme inhibitors |
Country Status (1)
Country | Link |
---|---|
CA (2) | CA2350941A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012151701A1 (en) * | 2011-05-10 | 2012-11-15 | Université Laval / Vice-Rectorat À La Recherche Et À La Création | Methods for the treatment and diagnostic of pulmonary arterial hypertension |
-
1995
- 1995-03-09 CA CA002350941A patent/CA2350941A1/en not_active Abandoned
- 1995-03-09 CA CA002352592A patent/CA2352592C/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012151701A1 (en) * | 2011-05-10 | 2012-11-15 | Université Laval / Vice-Rectorat À La Recherche Et À La Création | Methods for the treatment and diagnostic of pulmonary arterial hypertension |
Also Published As
Publication number | Publication date |
---|---|
CA2350941A1 (en) | 1995-09-14 |
CA2352592C (en) | 2006-06-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |