CA2352592A1 - Quinazolinone compounds - Google Patents

Quinazolinone compounds Download PDF

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Publication number
CA2352592A1
CA2352592A1 CA002352592A CA2352592A CA2352592A1 CA 2352592 A1 CA2352592 A1 CA 2352592A1 CA 002352592 A CA002352592 A CA 002352592A CA 2352592 A CA2352592 A CA 2352592A CA 2352592 A1 CA2352592 A1 CA 2352592A1
Authority
CA
Canada
Prior art keywords
compounds
aralkyl
benzyl
phenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002352592A
Other languages
French (fr)
Other versions
CA2352592C (en
Inventor
Roger John Griffin
Alan Hilary Calvert
Nicola Jane Curtin
David Richard Newell
Bernard Thomas Golding
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newcastle University Ventures Ltd
Original Assignee
Newcastle University Ventures Limited
Roger John Griffin
Alan Hilary Calvert
Nicola Jane Curtin
David Richard Newell
Bernard Thomas Golding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9404485A external-priority patent/GB9404485D0/en
Application filed by Newcastle University Ventures Limited, Roger John Griffin, Alan Hilary Calvert, Nicola Jane Curtin, David Richard Newell, Bernard Thomas Golding filed Critical Newcastle University Ventures Limited
Publication of CA2352592A1 publication Critical patent/CA2352592A1/en
Application granted granted Critical
Publication of CA2352592C publication Critical patent/CA2352592C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

A range of quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC
2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed comprise certain quinazolinone compounds having the general structural formula II
or pharmaceutically acceptable salt thereof, characterised in that X' represents hydroxyl, alkyl, alkoxy or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g. benzyl) group, and Y' represents hydrogen, alkyl or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g.
benzyl) group.
CA002352592A 1994-03-09 1995-03-09 Quinazolinone compounds Expired - Fee Related CA2352592C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9404485A GB9404485D0 (en) 1994-03-09 1994-03-09 Benzamide analogues
GB9404485.6 1994-03-09
CA002184747A CA2184747C (en) 1994-03-09 1995-03-09 Benzamide analogs, useful as parp (adp-ribosyltransferase, adprt) dna repair enzyme inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002184747A Division CA2184747C (en) 1994-03-09 1995-03-09 Benzamide analogs, useful as parp (adp-ribosyltransferase, adprt) dna repair enzyme inhibitors

Publications (2)

Publication Number Publication Date
CA2352592A1 true CA2352592A1 (en) 1995-09-14
CA2352592C CA2352592C (en) 2006-06-06

Family

ID=25678653

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002350941A Abandoned CA2350941A1 (en) 1994-03-09 1995-03-09 Benzamide analogues as parp dna repair enzyme inhibitors
CA002352592A Expired - Fee Related CA2352592C (en) 1994-03-09 1995-03-09 Quinazolinone compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002350941A Abandoned CA2350941A1 (en) 1994-03-09 1995-03-09 Benzamide analogues as parp dna repair enzyme inhibitors

Country Status (1)

Country Link
CA (2) CA2350941A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151701A1 (en) * 2011-05-10 2012-11-15 Université Laval / Vice-Rectorat À La Recherche Et À La Création Methods for the treatment and diagnostic of pulmonary arterial hypertension

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012151701A1 (en) * 2011-05-10 2012-11-15 Université Laval / Vice-Rectorat À La Recherche Et À La Création Methods for the treatment and diagnostic of pulmonary arterial hypertension

Also Published As

Publication number Publication date
CA2350941A1 (en) 1995-09-14
CA2352592C (en) 2006-06-06

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