CA2175587A1 - Synthetisation et criblage de diverses molecules - Google Patents

Synthetisation et criblage de diverses molecules

Info

Publication number
CA2175587A1
CA2175587A1 CA002175587A CA2175587A CA2175587A1 CA 2175587 A1 CA2175587 A1 CA 2175587A1 CA 002175587 A CA002175587 A CA 002175587A CA 2175587 A CA2175587 A CA 2175587A CA 2175587 A1 CA2175587 A1 CA 2175587A1
Authority
CA
Canada
Prior art keywords
beads
synthesis
tags
reaction
tag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002175587A
Other languages
English (en)
Inventor
Jeffrey H. Sugarman
Richard P. Rava
Haim Kedar
William J. Dower
Ronald W. Barrett
Mark A. Gallop
Michael C. Needels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affymax Technologies NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/149,675 external-priority patent/US5503805A/en
Priority claimed from US08/146,886 external-priority patent/US5639603A/en
Application filed by Individual filed Critical Individual
Publication of CA2175587A1 publication Critical patent/CA2175587A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
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  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention se rapporte à un dispositif et à un procédé permettant de synthétiser efficacement divers produits moléculaires sur des substrats. Une cuve principale (200) contient une suspension de substrats. Cette suspension est mise sous pression avec de l'argon et est transférée vers une pluralité de cuves de réaction (201-209) d'une ou de plusieurs rangées de cuves de réaction où ont lieu les réactions d'addition de monomères. Eventuellement, les substrats peuvent être marqués avec un monomère. Un moteur tourbillonnaire (300) fait tourbillonner le contenu des cuves de réaction (201-209) lors des réactions d'addition de monomères afin d'intensifier la synthèse. Après avoir obtenu la réaction désirée d'addition de monomère et/ou de monomère marqué, la suspension est mise sous pression avec de l'argon et est renvoyée dans la cuve principale (200) pour y être mélangée. Ensuite, cette suspension peut être mise sous pression avec de l'argon et être répartie entre des cuves de réaction (201-209) pour une autre synthèse.
CA002175587A 1993-11-02 1994-11-02 Synthetisation et criblage de diverses molecules Abandoned CA2175587A1 (fr)

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Application Number Priority Date Filing Date Title
US08/149,675 US5503805A (en) 1993-11-02 1993-11-02 Apparatus and method for parallel coupling reactions
US08/146,886 US5639603A (en) 1991-09-18 1993-11-02 Synthesizing and screening molecular diversity
US08/146,886 1993-11-02
US08/149,675 1993-11-02
PCT/US1994/012347 WO1995012608A1 (fr) 1993-11-02 1994-11-02 Synthetisation et criblage de diverses molecules

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CA (1) CA2175587A1 (fr)
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AU1128095A (en) 1995-05-23
GB2298863A (en) 1996-09-18
GB9609254D0 (en) 1996-07-03
CN1134156A (zh) 1996-10-23
GB2298863B (en) 1998-03-11
AU703472B2 (en) 1999-03-25
EP0726906A1 (fr) 1996-08-21
JPH09508353A (ja) 1997-08-26
NZ276860A (en) 1997-09-22
BR9407947A (pt) 1996-11-26
EP0726906A4 (fr) 1998-10-07

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