CA1327231C - Portable light unit for stimulating the neuroendocrine system and achieving phototherapy for depression - Google Patents
Portable light unit for stimulating the neuroendocrine system and achieving phototherapy for depressionInfo
- Publication number
- CA1327231C CA1327231C CA000592963A CA592963A CA1327231C CA 1327231 C CA1327231 C CA 1327231C CA 000592963 A CA000592963 A CA 000592963A CA 592963 A CA592963 A CA 592963A CA 1327231 C CA1327231 C CA 1327231C
- Authority
- CA
- Canada
- Prior art keywords
- light source
- lux
- producing
- light
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0618—Psychological treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
- A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
- A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
- A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Anesthesiology (AREA)
- Developmental Disabilities (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Social Psychology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ABSTRACT
Light weight phototherapeutic devices are provided that emit an illuminance of at least 200 lux on the eyes of a wearer. The device is portable and can be used in the phototherapy of depressed patients, shift-workers and those affected by jet-lag and seasonal affective disorders.
Light weight phototherapeutic devices are provided that emit an illuminance of at least 200 lux on the eyes of a wearer. The device is portable and can be used in the phototherapy of depressed patients, shift-workers and those affected by jet-lag and seasonal affective disorders.
Description
~ 327231 q~hi inven~lon ~a~ce~; 1;o app~ra~u~ and trea~ment~ ~or pho~o~ rapy ~nd in p~ticulEIr ~o more ~onvQnient tre~ Dnt~ ~or a~ecting ~h~ n~uro~ndocrine ~y~tela, ci~cadian rhythm~ ~n~ cl~cannual ~hythms in humans~
~9~ ;
~he 2~1010glcal ~g~ec~s o2 light are incre~E~ingly l:eing reoognlz~ playing~ ~n i~por~hnt role in ~od~rn he2~1thc:are. Phototherap~ u~ o~ llght ~ a tr~a~en~, h~4s beon ~uaoessfully u~od to treat ~ ~umb~r o~ disea~es including p~ori~si~ and r:Lclcetfi~. Nore r~cently, ~ienti~ts hav~ csov~r~aa ~t ~unli~ht ~la~8 ~ ~rlti~l role in 'c;tle regul~ltiLon o~ cir~adian ~nd ~ireann~al ~hyth~s in hu~an~. -Acco:~aihgly, in~rea~ea atte~t~ion i8 ~ing pai~ to ~he U~;e of phQtotll~rap~ in CliOEea~es in~lu~no~d by dally a~d ~asonal rhyth~s. Phototh~rapy ha~ en d2monstratef~ to : 2~ h~ve signific~mt ~ffects in thq; ~:reat~n'c~ o~ ~e~rer~l di~e~ e~ pa~i.~u~a~ $n~ t ~o p~ hiAtr~ ncl~ding a~Qctiv~ illn~ and chronolbiolc~gical d~;o~de~. It ha~
~1BO bO~r~ u~3ed w~ o~o ~UC~ in t~e t~ 'e~nt of p~ych~atri~: d~;o~d~ which Xa~re ~ 5'~sa~;o~aal C o~pon~n~
2S ~or exa~ple, ~s~a~on4~ ~f~ tiv~ di~ord~r ~8~cD~
Li ~ht. h8~ ~ee3n 6~hown tg~ hal~2 ~ ns~er o~
p~y~hological off~ct~ on th~ human c~nt~l n~rvou~ ~y~cm whio~ ~y ~e~ 8-pl~r~ 2 fro~ lt6 ~i~u~ f~:t~ ry brigh~
li~ht, i.o. ~ve abou~ ~000 luxl i~ cap~bl~ o~ ~lappr~ g ;~
` ~272~1 ~ ;~
the pr~ucl~ t~on ~n~ relea~e o~ t~e pineal ho~on~ An'd ¢an -qlet th~s ~ nternal "cloc~k", within ~ c~rta$ rl ra~, iFo~
c:irl:adlan rhythme . Ra~rRnae ~ ~ h~r~in ~ade ~o P . M .
Jacobsen e~ al. ~ 30nal ~ffective ~ order and the Use 5 of Light a~ an Antideprs2~ ntn, nlnca~o~, ~ol ~, 198~.
one c:urrently pre~ ibed treat~ent ~or p}~oto~herapy i~3 to hæ~e patient~ ~it ~pprc~xilllat~ly three $~et ~rom a light box ~hich typis:~lly h2~ diD~ension~ o~E
lO about a ~ by 4 ' . The~ light boxe~E; a~e q~nç~rally awkwar~l An~ ~u~berso~ to ue~e. Fllrtlhe~o~e, the patient~ ~e r~quired ts 8it: in one ~pot ~or approximat~ly on~ ~o ~iv~
hour~:, depending c\n their ~p~c:if i~ ~her~py . Thif~ hd~ been Potlnd to be res~ri~t.ive aJld lin-itirlg. A~ditionally, 1:~e~
15 d~3vioe3 are diffic~llt to tranE;port due t~ thei~ ~ize ~nd welght and gener~lly require an extern~l power souXc~.
Acaordingly, a need ~xi~ts fo~ ~ mob~le pho~otherapy treatman~ whi:~ would no~ re~uire patiexlt inaati~ty. In a~dition, ~ need exist~ ~o~ a 20 phototherapeutic devi~ which i~ lightwei~ht and s213~-eontained .
~ = .
In aac:ordan¢e with the lteaahing~; of this inventlon, an improved photother~peut~a deviae and z5 pho~otherapy metho~ are provideæ. $he invention i~
de~igned to sti~ul~te the neuroendocrina and circadian ~y~t~m~: aircan~ual of the p~tient with a ~ery l:~righ~ light of Rt: leaBt 200 1UX. ~ lighlt: ~IS portably ~o~ted to port~on~ oI th~ pati13nt'~: body, pr~erably-the h~aad, and i~
30 d~xected tow~d~ the Fa~ t'~ 2~e~ he liglht preferal:~ly u;e& a full white 1 ight fipeatrum e~n~ 18 ~Uppl ied wlt~ pow6~r lt* el b~t~:2ry whi~h i; p~ ra~ly ~eabargeable. The ~n~ention al~o m~y t::ho~s ~o defle~t heat: g~ne~ated from the light ~way from thkl pg~on tdearing th~ . It i~
35 en~isloned tha~ the l~ght c:an be oquipped with ~a dimmer itch o~ rheo~tat ~a that th~ u~er ~ay r~du~ th~
lr~te~n~ity o~ ~ch~ bulbE;. In ~ddi~lon, t:he ~ev~ce ~an be ~32~2~
pp~ ~ fll~r~, ~uch as ~ 3hrolc ~ neutral ~on~lty ~ o~ ~n~ ~ho~ r~ 8~ dl to blo~k or #orQen ~Is~gn~t~d r~ tlon, ~u~ in~ra~d OX
ultraviol~ ligh~. ~uch f~ltors e:An be ~ erpoS~ w~en 5 ~he l~np o~ the light ar~d t~e ua~r ' ~ ~yee n Ao~or~g~y, ~ ~hotothor~p~u~ic devic~ ahd ~ethc~d ar~ pro~f$d~a ~hi~h per~it ~inte~upted ~p~tient actlvity durlng tr~a~ment. The d~ e u~ed ~or ~h~ t~eatment o~ depres~on, su~:h aa~ SA~, or u~d by h~althy peop}~
lo invol~ed in ~h~ wor~c to ~rco~e ra~ ance b~ thei~
in~ernal ~locks.
~ hift work ch~llen~e~ the rlor~l blolc~
rhyth~; o~ hu~an being~. P$cple ~ho change work ~:hift~
o~en repor~ psyc:hological di~com~or~ and negati~re healtll lS ~:on~equ~noe~. Aooident~ and h~lth rel~ted abl~:enkeq~iem ~re oft~n hi~her among shi~t-work~r~ d~e ~o th~ str~ss ln ~hangin~ h~dulos. Tllo u~:e of the phototherapeutic d~ice of th~ invention ~ay pro~r~ b~n~ie~l in r~ etting the p~rson~ biolog~c~l ~lock when he or she ohans~e~ shif~.
20 Currantly, an e~tim~to~l 20-255e oi~ the ~o~)c Yor~:~ in the UnLte~d ~ta~ ln~olv~d in ~iw~e gon~ of ~hi~t workO
Finally, th~ pho'cotherapeutic: d~vic~ o~ thi~
lr.v~nt~or~ ~ay ~ u~eful fo~ people who t~avel by pl~ ~rer ~ult~plo time ~one:a. S~wh trlltrel~r~ ~xperienc~ ~ ~alady 25 kn~wn as ~2t-l~g" which oan sl~bilitR~e tl~e ~rav~ler for one to ~our day6 a~t~2r the 1iyhtO A~ wl~h ghift workers, the devic~ o thiE; in~ention miyht l~e u ~d ~or a 3Aor~
r~pi~, e~eGti~ r~setting o~ the internal ~iological clock, allowin5~ pr~VQnt~on or quic:ker ~co~r~ rom j~t 30 lay.
It i~:, therQ~oa~ an ob~e~;~ of this irnrentio~ ~o p~ov~de ~ porSab~e, hea~-mou~ate~ phototherapeuti~ dev~c~
~or th~ treat~n~ of p~;yc:hiatr$c dioo;rder~.
It i~ a~other obi~c1: o~ thlE; ~mr-3ntion to p~Ylde 35 a ~lf-containing photo~he~zlp~u~1¢ devi~:e for d~ rer~ng bri~h~ ligh~ tCI the U~ '6 eye'G ~or ~stl~ul~ttng the ci~ca~lan and nouroondocrine ~y~tl!~ c~ u3~r.
~272~
till ~noth~ ob~ao~ of ~i~ ln~ren'c~n ~o ~rovid~ an i~ro~e~d uathod oP phsto~he~y ~or ~r~a'Gia~lg ~oth p~yd~ r~ c: di~ord~ræ ~n~ ne~a~ he~lth oons@~uenc~s ~ oo~at~ ith ~;hift ~ork or ~0t l~g.
W~th tb~s~ and ot~r oh~ in ~ w, thi~
~nventio~l reaide~ in the nOY~ n8truoJtion~ a~bination arrange~n~ of part~ and n~etlaods ~ubot~nt~ally a~
h~reinaflte~ d~ ri}~d and aor~ p~ ulaxly de~ino4 by the atta~ d ~l~i~e.
~ he ~oc~pan~ g dr~ing~ illu~tr~ a c~ampl~te e~ ment csf ~h~ v~n~i~n ~ccordins~ to the }~est Dlode ~30 f;l3~ de~ ed ~or the practic~l appli~ation of th~ prinçipl~
thereo~ ~nd ~ n whie~
~ s a p~rl~p~tiv~ u~tration o~ a p~ erred port~le ~hototh0~ euti~ d~Ev1~e og:~ this invontion, ~quipped w~th ~ ~lide-mountQd ba~tery pa~
dimmer f~wit~h, li9ht 60ur~e ~nCI h~æ~t d~fl~'cor;
FIC. 2 ~ r~poo~re ll~u~tra~tion o~E another pre~rred, E~ort~bl~, pl~ototherAp@u~ e~odiment having top-mouA~ ba~t~ry paclc ~nd ~ront-mounted light ~urae:
FI~:. 3: i~ a p~re~c~ e vi~w o~ another photo~ t:herapeu~ic e~odlmen~ o~ thi8 inven~ion lnc~udlng a front ~ounted li~h~ source ~nd fi~ter; a~aa FI~:~ 4 ~ tr~n~ver~e Y~ r o~ another photothQr2~p~u~1c embo~ nt Or thi~ in~n~ion whic~2 !
in~ des a ~ont mount~l 1 $ght sourc~ ~nd romot~ bat~ery pai:k for providing a lighlt~r w~ight conllstruc~lotl7 ~ i 3 ~ R~r~in~ nc~w to the ~igure~ and p~ ularl~ ~o ~IG, 1, th~3r~ i~ ç;hown a po~able photothera~euti¢ d~vlc:~e ~,Q h~ving a heat d~1Ot:tor ;L~. ~n~ he~d ~nouJlting deYi~e 5 ~e ~ pro~rided ~ith a ligh~ ~ou~ce ~ and batto~y pa~lc 14. It beco~e~ r~d$1y ~pp~ren'c t~t thl~
3~ d~vicQ ~LQ o~r~co~ tho p~ob1e~a~ of ~xce~siv~ ~ize a~d brs~igl~t ~nd li~ited ~o~ ty by being llght weight, 8~1 c~ntain0d an~ h~a~ount~ deYlt~ at~ o 3b~
- ~32~2~1 -- S
~tt~d ~ith ~ rboo~t~t ~ ~or ~r~ltting ~ p~tio~t to ~d~u~t th~ lnt~n~ty o~ gh~ ~ou~co~.
An ~lt~ o~odi~on~ Lu~tr~t~d in 2 whi~h ~e~cr~ a photo~r~p~at~ ~eyis~ Q h~vinSI a 5 light ~ouroe ~ounted on ~n ~x~ sn o~ the ~ç~a~ m~3unl:ing :~eAn~ a~lon, ~e light ~ourc,q ~ aan be mor~
App~opriately ~o~u i;ed on t~e oyo3~ oiE ~ e~. !rhqa battery p~c:lc 2~ of thi~: e~bodi~t ~ tedl ~long lthe top porl:ion o~ t~e head ~ounting D~ ,o Ir~ ~IC. 3, A phototherapeu~ d~3via~ hewing radiation shi~ld ~ i~ deE~aribe~. ~e l~ght ~æour~e ~/ 0 ~his q~mbo~i~ont ~ taahed to the h~a~l ~c~nl~ing 3Dean~ ~, spoE;ed b4tw~en ~he eyes of t~e u~r ~nd th~a light ~c)urs:e ~ i~ a fil~r desigs~e~l to blo¢lc or ~cre~an designa~d 15 r~diati~n, ~uah ae~ ~fr~red o~ ultrallriolet llght. Th~
~ilt~r 36 aould al~o b~ ~ di~hrola or n~u~ral den6ity Pilter.
Re~4rrinq now to F~a. 4 ~ A ligh~-~$ight ph~o~erap~utic dQvicsll 4Q i~ illu6~r~ hAving ~ re~ote 20 battor~ bac~ . ~Q light s:ourc~ ~ ls di~po6~d on ~
~our~ting E~ean~ 4~, wh~ch ~an g~nerally a~ u~e th~ ape of ~un vi30r. Tla~3 device ~0 ie o~auipped w~th a DI~D~er ~i ~hich aan corre~pond ~o a ~ist~on ~ er ~-nd~ox ~ hea~
deflootion æhi~ld. ~tn a~cordance with thl~ particular 25 e~nbodinlent, a sl:r~p 48 a~n be p;covid~ ~or ad~lstm@nt to v~rio~ head ~iZQ$~ ;
~ h~ light E~ouro~ Z" ;~ or ~ pre~e~ y comp~ioe~ an incande~c~nt ~a~p, pre~e~ably a quar~z ~alog~n l~mp. The ~ntens~ty o~ th~ lll~inance pro~Uc~ y l;he$e 30 lamp~ 1?, 2~ 3~, and 42 ~hould ~ 1!15t: 20~
~lthouyh ~ore pre~er~ble ~ang~ include f~oDIl a~out 200 lUx to a~clut 10~00 luX, ~rsm ~bout 1000 ~ o abou~ 3000 luxo, ~ro~ ~ t 15D0 lux to o~ut 27Q0 lux, and ~o~ prsr~rab~y ~rom ~bou'c 2000 lu~c 'co about 2500 l~X~r rhe latter r~nsle 35 h~ be~3n r~aoognized ~ ac¢ept~ . For ~n~tanco, s~cudle~
o~ phototherapy ~lth ~goA~ p~ticnts h~e con~lu~l~d th;~
bri~ht llg~ 500 lux) iE~ ~ignlfic:~n~l~r ~o~ ~ffeo~iv~ aE;
` ~32 123~
an An~idep~es~an~ than ~he in~en~î~y of light ordlna~lly ~ound in a ho~a or o~ (100-300 lux~. Soe Jacob~en, ~S~a~onal Af~e~tiYe ~i~ord~r and ~he U~e of ~igh~
a~ an ~nti-Depre~ant~ EYr Vol~ 6, 1~8~.
One a~pt~le traat~n~ ~or t~e ~i~mpto~ of Sea~onal Affe~ve ~i~ord~r c~uld b0 to ~xpos~ patle~ts ~o ~he bright ar~ ial light pr2du~ y ~hQ
pho~other~peudi~ device~ of th~ in~ention for a period o~
S to ~ hour~ per day. It i~ ~nder~tood th~ the anti-dep~es~ant effeat~ could app~ar within ~ to 6 day~ a~ter the commenaement of tr~atmont, and a relapse v~ten could occur 2-4 day~ ~f~er light ~reatment i~ di~continued.
In the t~ea~ment of manic-~epre~sive patients, an 15 expo~ure to 500 lux ha~ been known t~ cau~e a 50~
~uppr~s~ion o~ melatohin levels~ bu~ produced no ef~et in ~he con~rols. A.J~ L~Wy, ~t ~1, '9~ani~-d~pre~iY~ Patientæ
~ay Be Supe~6ensitive to ~igh~ he ~ncet~ p. 3~4, ~ebru~ry 14, 198~ ha~ ~180 ~ean de~onstrat~d that when ma~ic-~pre~nt~ were expo~ed to ~ ht lnten~ity of 15~0 lux, al~o~t ~o~plete suppressiQn ~f mela~onin æeoretion w~
no~ed, re ul~ing in level~ of approaching ~hos~ o~erved durlng dayt~mc in two healthy ~ub~ect~. ~c~ordin~lyJ ~he use og the de~ice~ of th$~ invention coul~ be used to ~uppre ~ hu~an mela~onin ~e~re~ion in manic-depre~nt~ and alter the e~vironm~ntal ligh~-cy~le Which generat~ thelx cir~adian rhy~h~, From the for~go$n~ ha~ be~n demon~tra~ed that this inven~ion prcwi~ port~ble, light-weighlt 3 o phototh~rapeu~ d~vice~ gor ~t~ul~ting a patlen~ ' ~
c:irc:Adian 6y~t~ and a~soc~ated ~euro~ndocrine parameter~ .
Althoug~ ~riou$ embo~iment~ hatJ~ be~n lll~s~ra~e~l, this w;~ for the purpo~e of ~escrlbing, but no~ ll~i~ing t~e inven~ n. Variou~ modif~r:~tions, whic~h will b~G~me 35 apparent to on~ Q~ ed in the ~rt, aro wi~chin the ~cvpe o:~
thl~ in~ention de~ribsd in ~he att2~ch~q clai~n~.
~9~ ;
~he 2~1010glcal ~g~ec~s o2 light are incre~E~ingly l:eing reoognlz~ playing~ ~n i~por~hnt role in ~od~rn he2~1thc:are. Phototherap~ u~ o~ llght ~ a tr~a~en~, h~4s beon ~uaoessfully u~od to treat ~ ~umb~r o~ disea~es including p~ori~si~ and r:Lclcetfi~. Nore r~cently, ~ienti~ts hav~ csov~r~aa ~t ~unli~ht ~la~8 ~ ~rlti~l role in 'c;tle regul~ltiLon o~ cir~adian ~nd ~ireann~al ~hyth~s in hu~an~. -Acco:~aihgly, in~rea~ea atte~t~ion i8 ~ing pai~ to ~he U~;e of phQtotll~rap~ in CliOEea~es in~lu~no~d by dally a~d ~asonal rhyth~s. Phototh~rapy ha~ en d2monstratef~ to : 2~ h~ve signific~mt ~ffects in thq; ~:reat~n'c~ o~ ~e~rer~l di~e~ e~ pa~i.~u~a~ $n~ t ~o p~ hiAtr~ ncl~ding a~Qctiv~ illn~ and chronolbiolc~gical d~;o~de~. It ha~
~1BO bO~r~ u~3ed w~ o~o ~UC~ in t~e t~ 'e~nt of p~ych~atri~: d~;o~d~ which Xa~re ~ 5'~sa~;o~aal C o~pon~n~
2S ~or exa~ple, ~s~a~on4~ ~f~ tiv~ di~ord~r ~8~cD~
Li ~ht. h8~ ~ee3n 6~hown tg~ hal~2 ~ ns~er o~
p~y~hological off~ct~ on th~ human c~nt~l n~rvou~ ~y~cm whio~ ~y ~e~ 8-pl~r~ 2 fro~ lt6 ~i~u~ f~:t~ ry brigh~
li~ht, i.o. ~ve abou~ ~000 luxl i~ cap~bl~ o~ ~lappr~ g ;~
` ~272~1 ~ ;~
the pr~ucl~ t~on ~n~ relea~e o~ t~e pineal ho~on~ An'd ¢an -qlet th~s ~ nternal "cloc~k", within ~ c~rta$ rl ra~, iFo~
c:irl:adlan rhythme . Ra~rRnae ~ ~ h~r~in ~ade ~o P . M .
Jacobsen e~ al. ~ 30nal ~ffective ~ order and the Use 5 of Light a~ an Antideprs2~ ntn, nlnca~o~, ~ol ~, 198~.
one c:urrently pre~ ibed treat~ent ~or p}~oto~herapy i~3 to hæ~e patient~ ~it ~pprc~xilllat~ly three $~et ~rom a light box ~hich typis:~lly h2~ diD~ension~ o~E
lO about a ~ by 4 ' . The~ light boxe~E; a~e q~nç~rally awkwar~l An~ ~u~berso~ to ue~e. Fllrtlhe~o~e, the patient~ ~e r~quired ts 8it: in one ~pot ~or approximat~ly on~ ~o ~iv~
hour~:, depending c\n their ~p~c:if i~ ~her~py . Thif~ hd~ been Potlnd to be res~ri~t.ive aJld lin-itirlg. A~ditionally, 1:~e~
15 d~3vioe3 are diffic~llt to tranE;port due t~ thei~ ~ize ~nd welght and gener~lly require an extern~l power souXc~.
Acaordingly, a need ~xi~ts fo~ ~ mob~le pho~otherapy treatman~ whi:~ would no~ re~uire patiexlt inaati~ty. In a~dition, ~ need exist~ ~o~ a 20 phototherapeutic devi~ which i~ lightwei~ht and s213~-eontained .
~ = .
In aac:ordan¢e with the lteaahing~; of this inventlon, an improved photother~peut~a deviae and z5 pho~otherapy metho~ are provideæ. $he invention i~
de~igned to sti~ul~te the neuroendocrina and circadian ~y~t~m~: aircan~ual of the p~tient with a ~ery l:~righ~ light of Rt: leaBt 200 1UX. ~ lighlt: ~IS portably ~o~ted to port~on~ oI th~ pati13nt'~: body, pr~erably-the h~aad, and i~
30 d~xected tow~d~ the Fa~ t'~ 2~e~ he liglht preferal:~ly u;e& a full white 1 ight fipeatrum e~n~ 18 ~Uppl ied wlt~ pow6~r lt* el b~t~:2ry whi~h i; p~ ra~ly ~eabargeable. The ~n~ention al~o m~y t::ho~s ~o defle~t heat: g~ne~ated from the light ~way from thkl pg~on tdearing th~ . It i~
35 en~isloned tha~ the l~ght c:an be oquipped with ~a dimmer itch o~ rheo~tat ~a that th~ u~er ~ay r~du~ th~
lr~te~n~ity o~ ~ch~ bulbE;. In ~ddi~lon, t:he ~ev~ce ~an be ~32~2~
pp~ ~ fll~r~, ~uch as ~ 3hrolc ~ neutral ~on~lty ~ o~ ~n~ ~ho~ r~ 8~ dl to blo~k or #orQen ~Is~gn~t~d r~ tlon, ~u~ in~ra~d OX
ultraviol~ ligh~. ~uch f~ltors e:An be ~ erpoS~ w~en 5 ~he l~np o~ the light ar~d t~e ua~r ' ~ ~yee n Ao~or~g~y, ~ ~hotothor~p~u~ic devic~ ahd ~ethc~d ar~ pro~f$d~a ~hi~h per~it ~inte~upted ~p~tient actlvity durlng tr~a~ment. The d~ e u~ed ~or ~h~ t~eatment o~ depres~on, su~:h aa~ SA~, or u~d by h~althy peop}~
lo invol~ed in ~h~ wor~c to ~rco~e ra~ ance b~ thei~
in~ernal ~locks.
~ hift work ch~llen~e~ the rlor~l blolc~
rhyth~; o~ hu~an being~. P$cple ~ho change work ~:hift~
o~en repor~ psyc:hological di~com~or~ and negati~re healtll lS ~:on~equ~noe~. Aooident~ and h~lth rel~ted abl~:enkeq~iem ~re oft~n hi~her among shi~t-work~r~ d~e ~o th~ str~ss ln ~hangin~ h~dulos. Tllo u~:e of the phototherapeutic d~ice of th~ invention ~ay pro~r~ b~n~ie~l in r~ etting the p~rson~ biolog~c~l ~lock when he or she ohans~e~ shif~.
20 Currantly, an e~tim~to~l 20-255e oi~ the ~o~)c Yor~:~ in the UnLte~d ~ta~ ln~olv~d in ~iw~e gon~ of ~hi~t workO
Finally, th~ pho'cotherapeutic: d~vic~ o~ thi~
lr.v~nt~or~ ~ay ~ u~eful fo~ people who t~avel by pl~ ~rer ~ult~plo time ~one:a. S~wh trlltrel~r~ ~xperienc~ ~ ~alady 25 kn~wn as ~2t-l~g" which oan sl~bilitR~e tl~e ~rav~ler for one to ~our day6 a~t~2r the 1iyhtO A~ wl~h ghift workers, the devic~ o thiE; in~ention miyht l~e u ~d ~or a 3Aor~
r~pi~, e~eGti~ r~setting o~ the internal ~iological clock, allowin5~ pr~VQnt~on or quic:ker ~co~r~ rom j~t 30 lay.
It i~:, therQ~oa~ an ob~e~;~ of this irnrentio~ ~o p~ov~de ~ porSab~e, hea~-mou~ate~ phototherapeuti~ dev~c~
~or th~ treat~n~ of p~;yc:hiatr$c dioo;rder~.
It i~ a~other obi~c1: o~ thlE; ~mr-3ntion to p~Ylde 35 a ~lf-containing photo~he~zlp~u~1¢ devi~:e for d~ rer~ng bri~h~ ligh~ tCI the U~ '6 eye'G ~or ~stl~ul~ttng the ci~ca~lan and nouroondocrine ~y~tl!~ c~ u3~r.
~272~
till ~noth~ ob~ao~ of ~i~ ln~ren'c~n ~o ~rovid~ an i~ro~e~d uathod oP phsto~he~y ~or ~r~a'Gia~lg ~oth p~yd~ r~ c: di~ord~ræ ~n~ ne~a~ he~lth oons@~uenc~s ~ oo~at~ ith ~;hift ~ork or ~0t l~g.
W~th tb~s~ and ot~r oh~ in ~ w, thi~
~nventio~l reaide~ in the nOY~ n8truoJtion~ a~bination arrange~n~ of part~ and n~etlaods ~ubot~nt~ally a~
h~reinaflte~ d~ ri}~d and aor~ p~ ulaxly de~ino4 by the atta~ d ~l~i~e.
~ he ~oc~pan~ g dr~ing~ illu~tr~ a c~ampl~te e~ ment csf ~h~ v~n~i~n ~ccordins~ to the }~est Dlode ~30 f;l3~ de~ ed ~or the practic~l appli~ation of th~ prinçipl~
thereo~ ~nd ~ n whie~
~ s a p~rl~p~tiv~ u~tration o~ a p~ erred port~le ~hototh0~ euti~ d~Ev1~e og:~ this invontion, ~quipped w~th ~ ~lide-mountQd ba~tery pa~
dimmer f~wit~h, li9ht 60ur~e ~nCI h~æ~t d~fl~'cor;
FIC. 2 ~ r~poo~re ll~u~tra~tion o~E another pre~rred, E~ort~bl~, pl~ototherAp@u~ e~odiment having top-mouA~ ba~t~ry paclc ~nd ~ront-mounted light ~urae:
FI~:. 3: i~ a p~re~c~ e vi~w o~ another photo~ t:herapeu~ic e~odlmen~ o~ thi8 inven~ion lnc~udlng a front ~ounted li~h~ source ~nd fi~ter; a~aa FI~:~ 4 ~ tr~n~ver~e Y~ r o~ another photothQr2~p~u~1c embo~ nt Or thi~ in~n~ion whic~2 !
in~ des a ~ont mount~l 1 $ght sourc~ ~nd romot~ bat~ery pai:k for providing a lighlt~r w~ight conllstruc~lotl7 ~ i 3 ~ R~r~in~ nc~w to the ~igure~ and p~ ularl~ ~o ~IG, 1, th~3r~ i~ ç;hown a po~able photothera~euti¢ d~vlc:~e ~,Q h~ving a heat d~1Ot:tor ;L~. ~n~ he~d ~nouJlting deYi~e 5 ~e ~ pro~rided ~ith a ligh~ ~ou~ce ~ and batto~y pa~lc 14. It beco~e~ r~d$1y ~pp~ren'c t~t thl~
3~ d~vicQ ~LQ o~r~co~ tho p~ob1e~a~ of ~xce~siv~ ~ize a~d brs~igl~t ~nd li~ited ~o~ ty by being llght weight, 8~1 c~ntain0d an~ h~a~ount~ deYlt~ at~ o 3b~
- ~32~2~1 -- S
~tt~d ~ith ~ rboo~t~t ~ ~or ~r~ltting ~ p~tio~t to ~d~u~t th~ lnt~n~ty o~ gh~ ~ou~co~.
An ~lt~ o~odi~on~ Lu~tr~t~d in 2 whi~h ~e~cr~ a photo~r~p~at~ ~eyis~ Q h~vinSI a 5 light ~ouroe ~ounted on ~n ~x~ sn o~ the ~ç~a~ m~3unl:ing :~eAn~ a~lon, ~e light ~ourc,q ~ aan be mor~
App~opriately ~o~u i;ed on t~e oyo3~ oiE ~ e~. !rhqa battery p~c:lc 2~ of thi~: e~bodi~t ~ tedl ~long lthe top porl:ion o~ t~e head ~ounting D~ ,o Ir~ ~IC. 3, A phototherapeu~ d~3via~ hewing radiation shi~ld ~ i~ deE~aribe~. ~e l~ght ~æour~e ~/ 0 ~his q~mbo~i~ont ~ taahed to the h~a~l ~c~nl~ing 3Dean~ ~, spoE;ed b4tw~en ~he eyes of t~e u~r ~nd th~a light ~c)urs:e ~ i~ a fil~r desigs~e~l to blo¢lc or ~cre~an designa~d 15 r~diati~n, ~uah ae~ ~fr~red o~ ultrallriolet llght. Th~
~ilt~r 36 aould al~o b~ ~ di~hrola or n~u~ral den6ity Pilter.
Re~4rrinq now to F~a. 4 ~ A ligh~-~$ight ph~o~erap~utic dQvicsll 4Q i~ illu6~r~ hAving ~ re~ote 20 battor~ bac~ . ~Q light s:ourc~ ~ ls di~po6~d on ~
~our~ting E~ean~ 4~, wh~ch ~an g~nerally a~ u~e th~ ape of ~un vi30r. Tla~3 device ~0 ie o~auipped w~th a DI~D~er ~i ~hich aan corre~pond ~o a ~ist~on ~ er ~-nd~ox ~ hea~
deflootion æhi~ld. ~tn a~cordance with thl~ particular 25 e~nbodinlent, a sl:r~p 48 a~n be p;covid~ ~or ad~lstm@nt to v~rio~ head ~iZQ$~ ;
~ h~ light E~ouro~ Z" ;~ or ~ pre~e~ y comp~ioe~ an incande~c~nt ~a~p, pre~e~ably a quar~z ~alog~n l~mp. The ~ntens~ty o~ th~ lll~inance pro~Uc~ y l;he$e 30 lamp~ 1?, 2~ 3~, and 42 ~hould ~ 1!15t: 20~
~lthouyh ~ore pre~er~ble ~ang~ include f~oDIl a~out 200 lUx to a~clut 10~00 luX, ~rsm ~bout 1000 ~ o abou~ 3000 luxo, ~ro~ ~ t 15D0 lux to o~ut 27Q0 lux, and ~o~ prsr~rab~y ~rom ~bou'c 2000 lu~c 'co about 2500 l~X~r rhe latter r~nsle 35 h~ be~3n r~aoognized ~ ac¢ept~ . For ~n~tanco, s~cudle~
o~ phototherapy ~lth ~goA~ p~ticnts h~e con~lu~l~d th;~
bri~ht llg~ 500 lux) iE~ ~ignlfic:~n~l~r ~o~ ~ffeo~iv~ aE;
` ~32 123~
an An~idep~es~an~ than ~he in~en~î~y of light ordlna~lly ~ound in a ho~a or o~ (100-300 lux~. Soe Jacob~en, ~S~a~onal Af~e~tiYe ~i~ord~r and ~he U~e of ~igh~
a~ an ~nti-Depre~ant~ EYr Vol~ 6, 1~8~.
One a~pt~le traat~n~ ~or t~e ~i~mpto~ of Sea~onal Affe~ve ~i~ord~r c~uld b0 to ~xpos~ patle~ts ~o ~he bright ar~ ial light pr2du~ y ~hQ
pho~other~peudi~ device~ of th~ in~ention for a period o~
S to ~ hour~ per day. It i~ ~nder~tood th~ the anti-dep~es~ant effeat~ could app~ar within ~ to 6 day~ a~ter the commenaement of tr~atmont, and a relapse v~ten could occur 2-4 day~ ~f~er light ~reatment i~ di~continued.
In the t~ea~ment of manic-~epre~sive patients, an 15 expo~ure to 500 lux ha~ been known t~ cau~e a 50~
~uppr~s~ion o~ melatohin levels~ bu~ produced no ef~et in ~he con~rols. A.J~ L~Wy, ~t ~1, '9~ani~-d~pre~iY~ Patientæ
~ay Be Supe~6ensitive to ~igh~ he ~ncet~ p. 3~4, ~ebru~ry 14, 198~ ha~ ~180 ~ean de~onstrat~d that when ma~ic-~pre~nt~ were expo~ed to ~ ht lnten~ity of 15~0 lux, al~o~t ~o~plete suppressiQn ~f mela~onin æeoretion w~
no~ed, re ul~ing in level~ of approaching ~hos~ o~erved durlng dayt~mc in two healthy ~ub~ect~. ~c~ordin~lyJ ~he use og the de~ice~ of th$~ invention coul~ be used to ~uppre ~ hu~an mela~onin ~e~re~ion in manic-depre~nt~ and alter the e~vironm~ntal ligh~-cy~le Which generat~ thelx cir~adian rhy~h~, From the for~go$n~ ha~ be~n demon~tra~ed that this inven~ion prcwi~ port~ble, light-weighlt 3 o phototh~rapeu~ d~vice~ gor ~t~ul~ting a patlen~ ' ~
c:irc:Adian 6y~t~ and a~soc~ated ~euro~ndocrine parameter~ .
Althoug~ ~riou$ embo~iment~ hatJ~ be~n lll~s~ra~e~l, this w;~ for the purpo~e of ~escrlbing, but no~ ll~i~ing t~e inven~ n. Variou~ modif~r:~tions, whic~h will b~G~me 35 apparent to on~ Q~ ed in the ~rt, aro wi~chin the ~cvpe o:~
thl~ in~ention de~ribsd in ~he att2~ch~q clai~n~.
Claims (14)
1. A phototherapeutic device for treating a patient comprising:
(a) a light source for producing an illuminance of at least 200 lux on the eyes of said patient; and (b) mounting means for affixing said light source to a portion of the patient's body,
(a) a light source for producing an illuminance of at least 200 lux on the eyes of said patient; and (b) mounting means for affixing said light source to a portion of the patient's body,
2. The device of claim 1 wherein said mounting means comprises means of attaching said light source to a patient's head.
3. The device of claim 1 wherein said light source comprises means for producing an illuminance of at least about 200 lux to about 10,000 lux.
4. The device of claim 1 wherein said light source comprises means for producing an illuminance of about 1000 lux to about 3000 lux.
5. The device of claim 1 wherein said light source comprises means for producing an illuminance of about 1500 lux to about 2700 lux.
6. The device of claim 1 wherein light source comprises means for producing an illuminance of about 2000 lux to about 2500 lux.
7. The device of claim 1 wherein said light source comprises means for producing light having a broad-spectrum white light component.
8. The device of claim 4 wherein said light source comprises means for producing green light.
9. The device of claim 1 wherein said light source comprises means for producing blue-green light.
10. The device of claim 7 further comprising heat deflector means for deflecting a portion of the heat from said light source away from the head of said patient.
11. The device of claim 10 wherein said heat deflection means comprises a reflector.
12. the device of claim 10 wherein said heat deflection means comprises a dichroic filter.
13. The device of claim 7 further comprises an ultraviolet filter.
14. The device of claim 7 further comprising a neutral density filter disposed between said light source and said eyes of said patient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000617066A CA1339384E (en) | 1988-03-08 | 1989-03-07 | Portable light unit for stimulating the neuroendocrine system and achieving phototherapy for depression |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16528588A | 1988-03-08 | 1988-03-08 | |
| US165,285 | 1988-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1327231C true CA1327231C (en) | 1994-02-22 |
Family
ID=22598265
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000617066A Expired - Fee Related CA1339384E (en) | 1988-03-08 | 1989-03-07 | Portable light unit for stimulating the neuroendocrine system and achieving phototherapy for depression |
| CA000592963A Expired - Lifetime CA1327231C (en) | 1988-03-08 | 1989-03-07 | Portable light unit for stimulating the neuroendocrine system and achieving phototherapy for depression |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000617066A Expired - Fee Related CA1339384E (en) | 1988-03-08 | 1989-03-07 | Portable light unit for stimulating the neuroendocrine system and achieving phototherapy for depression |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0386161A4 (en) |
| JP (1) | JP2513876B2 (en) |
| CA (2) | CA1339384E (en) |
| WO (1) | WO1989008475A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5503637A (en) * | 1987-06-26 | 1996-04-02 | Light Sciences, Inc. | Apparatus for producing and delivering high-intensity light to a subject |
| JPH09213101A (en) * | 1995-11-27 | 1997-08-15 | Matsushita Electric Works Ltd | Portable light irradiation device |
| EP1283733A1 (en) * | 2000-05-10 | 2003-02-19 | Thomas Jefferson University | Photoreceptor system for melatonin regulation and phototherapy |
| US6488698B1 (en) | 2000-08-16 | 2002-12-03 | Henry H. Hyman | Portable light unit for treatment of seasonal affective disorders |
| US7276025B2 (en) | 2003-03-20 | 2007-10-02 | Welch Allyn, Inc. | Electrical adapter for medical diagnostic instruments using LEDs as illumination sources |
| US10252079B2 (en) * | 2003-06-06 | 2019-04-09 | Koninklijke Philips N.V. | Hand-held light therapy apparatus |
| US8459844B2 (en) | 2010-07-01 | 2013-06-11 | Welch Allyn, Inc. | Replacement light assembly |
| CA2812302A1 (en) * | 2010-09-29 | 2012-04-05 | Yumalite Inc. | Head mounted light therapy device |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH455071A (en) * | 1967-11-30 | 1968-04-30 | Castells Toha Luis | Device for sending monochromatic radiation into the eye for therapeutic purposes |
| US4057054A (en) * | 1976-05-20 | 1977-11-08 | Giannone Frank C | Eye treatment apparatus |
| JPS5318288A (en) * | 1976-08-02 | 1978-02-20 | Tokuji Suzuki | Mental rest or sleep inducing apparatus |
| US4315502A (en) * | 1979-10-11 | 1982-02-16 | Gorges Denis E | Learning-relaxation device |
| JPS58173563A (en) * | 1982-04-06 | 1983-10-12 | 三菱電機株式会社 | Sleep inducer |
| AT382784B (en) * | 1982-06-16 | 1987-04-10 | Stiegler Reinhard Dr | DEVICE FOR REDUCING MENTAL TENSIONS |
| AU614800B2 (en) * | 1987-12-24 | 1991-09-12 | Optron Pty Ltd | Chromo therapy device |
-
1989
- 1989-03-07 CA CA000617066A patent/CA1339384E/en not_active Expired - Fee Related
- 1989-03-07 CA CA000592963A patent/CA1327231C/en not_active Expired - Lifetime
- 1989-03-08 EP EP19890903619 patent/EP0386161A4/en not_active Withdrawn
- 1989-03-08 JP JP1503356A patent/JP2513876B2/en not_active Expired - Lifetime
- 1989-03-08 WO PCT/US1989/000934 patent/WO1989008475A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989008475A1 (en) | 1989-09-21 |
| EP0386161A1 (en) | 1990-09-12 |
| JP2513876B2 (en) | 1996-07-03 |
| CA1339384E (en) | 1997-08-26 |
| JPH03501936A (en) | 1991-05-09 |
| EP0386161A4 (en) | 1992-02-19 |
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