CA1181696A - Filter - Google Patents
FilterInfo
- Publication number
- CA1181696A CA1181696A CA000393836A CA393836A CA1181696A CA 1181696 A CA1181696 A CA 1181696A CA 000393836 A CA000393836 A CA 000393836A CA 393836 A CA393836 A CA 393836A CA 1181696 A CA1181696 A CA 1181696A
- Authority
- CA
- Canada
- Prior art keywords
- fluid flow
- cavity
- filter
- bore
- flow paths
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A novel filter structure is provided which permits the filtration or concentration of liquids to purify the same.
The filter has a generally flat rectangular construction and a planar filter membrane is supported in a cavity within the filter to permit passage of selected materials only therethrough.
The liquid to be processed is passed in parallel paths over the face of the membrane from one end of the cavity to the other and the selected materials pass through the membrane for removal from the cavity, the non-selected materials being removed from the cavity in a more concentrated form.
A novel filter structure is provided which permits the filtration or concentration of liquids to purify the same.
The filter has a generally flat rectangular construction and a planar filter membrane is supported in a cavity within the filter to permit passage of selected materials only therethrough.
The liquid to be processed is passed in parallel paths over the face of the membrane from one end of the cavity to the other and the selected materials pass through the membrane for removal from the cavity, the non-selected materials being removed from the cavity in a more concentrated form.
Description
FILTER
_ Th~ pres~nt invention relates to a filter housing ~or holding linear tangential membrane filters.
There are many instances where separation of a desired 5 microorganism or dxug from impurities is required to be effected, especially in the production o IV fluids, insulin, viral and bacterial vaccines and other drugs in pure form. The prior art has made several approaches to this purification problem and none has been entirely satisfactory.
One prior art approach is the use of chemical absorp-tion and adsorption but such procedures are expensive and occasionally introduce toxicity to the product, thereby causing advèrse reaction when administered. Centrifugation has been used with excellent results but the cost of equipment and 15 operation is very highO
Straight through filtration is another approach but suffers from the drawback that there is a low throughput and a low recovery. Stralght through filtration is suitable only for final filtration when, for example, microorganisms must be removed from a liquid with moderate levels of suspended solids.
Tangential filter membrane holders are known and have shown promising results. However, the circular design of such holders limlts the utility to laboratory testing and research applications where only small volumes are filtered.
A yet further prior art approach is the utilization o ultrafiltration in the form of casettes, spiral wound cartridges, hollow tube cartridges, hollow fiber cartridges and plate and frame types. A11 but the hollow tube cartridge clog up when particulate concentration is high and/or when particu-late sizes exceed 5 microns. However, the hollow tube cartridge has not been developed for pharmaceutical applica-tions, where a high level of residue-free sanitation and/or sterilization are required. In addition, ultrafiltration cartridges are limited in pore size, membrane material and flow pattern-The prior art, therefore, suffers the major disadvan-~f~36 tages of cost and toxic side effects, along with other problems,such as, space requirement, inflexibility, high energy use, sophis~icated equlpment operation and product loss.
In accordance with the present invention, there is provided a novel filter which enables the defects of the prior art to be overcome and enables purification of biological fluids to be attained in a simple, inexpensive and low energy requirement manner.
The filter of the present invention comprlses upper and lower generally planar and rectangulax housing portions -~hich are releasably joined together and define a cavity therein.
A planar filter medium spans the cavity and is supported therein to separate the cavity into two fluid flow zones. Each of the fluid flow zones is separated into a plurality of parallel fluid flow paths extending from one end to the other, with each flow path being of essentially uniform cross-sectional flow area.
An lnlet communicates in parallel with the fluid flow paths in one only of the fluid flow zones at one end thereof and a first outlet communicates in parallel with the same fluid flow paths at the other end thereof. A second outlet communicates in parallel with the fluid flow paths only in the other of the fluid flow path zones.
Liquid to be concentrated or filtered is flowed from the inlet along the fluid flow paths in the one fluid flow zone 25 across the face of the filter medium~ Some liquid, dissolved material and particulates pass through the filter medium int-.
the fluid flow p~ths in the other of the fluid flow zones and flo~ out of the second outlet r while the remainder of the liquid, dissolved material and particulates flow out of the 30 first outlet. Depending on the pore size of the filter membrane and the relative particle sizes of the desired or undesired materials~ desired materials may be filtered and collected as the permeate or may be concentrated.
The invention is described further, by way of illustration, 3~ with reference to the accompanying drawings, in which:
Figure 1 is a perspective view, with parts cut-away for clarity, of a filter in accordance with one preferred embodiment of the invention;
Figure 2 is a sectional view of the ~ilter housing 40 taken on line 2-2 of Figure l; and Figure 3 is a schematic xepresenta-tion oE a filtra-tion apparatus embodying the filter housing of Figures 1 and Referring first to Figures 1 and 2 of the drawings, 5 which illustrate the current best mode of the invention known to the applican~, a filter 10 is provided. The filter 10 is generally planar and of rectangular shape and includes an upper housing portion 12 and a lower housing portion 14 joined together by any suitable means, such as bolts 16.
The lower housing portion 14 has an integral upstand-ing wall member 18 extending perimetrically adjacent the outer perimeter of the lower housing portion 14. The upper surface 20 of -the w?ll 18 has a groove 22 therein in which is seated a sealing O-ring 24.
The wall 18 acts as a spacing element and receives a perimeter surface 26 of the upper housing portion 12 in engage-ment with the upper surface 20 of the wall 18 when the housing 10 is assembled, the O-ring 24 providing a fluid tight seal in the area of engagement.
The upper housing portion 12 has an integral upstand-ing wall member 28 extending perimetrically immediately adjacent to and defining the inner extremity of the perimeter surface 26 and-having a lower surface 30. When the upper housing portion 12 is assembled with the lower portion 14 the 25 wall member 28 extends downwardly in engagement with the wall member 18 towards an annular surface 32 of the lower lousing portion 14, which has a sealing O-ring 34 seated in a groove 36 formed therein.
Mounted between lower surface 30 of the wall 28 and 30 the annular surface 32 is a filter medium 37 consisting of a porous filter support plate 38 and a filter membrane 40. The filter support plate 38 may be of any convenient construction to permit fluid flow therethrough while supporting the filter membrane 40. The filter membrane 40 may be of any convenient 35 type having pore sizes sufficient to achieve the desired fil-trationO For example, Millipore Corporation manufacture and sell a line of filter membranes of differing pore size from 10,000 NMWL to 8 microns, which are suitable for use in the filter lO.
A cavity 42 is deined in the interior of the filter lO by a recessed inner surface 44 in the lower housing portion 14 whi.ch is spaced from the inner surface 46 of the 5 upper housing portion 12. The filter medium 37 spans the cavity 42 and separates the same into a lower fluid flow zone 48 and an upper fluid flow zone 50.
Upstanding from and integral with the recessed surface 44 are spaced ribs 52 which extend in parallelism from 10 one end of the recessed surface 44 to the other. The ribs 52 extend upwardly into engagement with the underside of the filter medium ~7to separate the lower fluid flow zone 48 into three parallel flow paths 54.
Similarly, upstanding from and integral with the inn~r 15 surface 46 of the upper housing portion 12 are spaced ribs 56 which extend in parallelism from one end of the surface 46 to the other. The ribs 56 extend downwardly coplanarly with the corresponding ribs 52 and into engagement with the topside of the ~ilter medium 37to sand~ich t~e filter medium 37 between 20 the ribs 52 and 56 and to separate the upper fluid flow zone 48 into three parallel flow paths 58.
~ n inlet bore 60 extends from one side of the lower housing portion 14 towards the other and communicates in parallel with the flow paths 54 through depressions 62 in the 25 recessed surf~ce 44 which intersect the inlet bore 60.
An outlet bore 64 extends from the sa~e side of the lower housing portion 14 towards the other and communicates in parallel with the flow paths 54 through depressions 66 in the recessed surface 44 which intersect the outlet bore 64. If 30 desired, the outlet bore 64 may extend from the other side of the lower housing portion 14 from the inlet bore 62.
A second outlet bore 68 extends from one side of the upper housing portion 12 towards the other at approximately the midpoint of the length thereof so as to avoid inter-35 ference of the flow line therefrom with those communicatingwith bores 60 and 64~ The outlet bore 68 communicates in parallel with the flow paths 58 through grooves 70 cut into the inner surface 46 of the upper housing portion 12 and intersec~ng the bore 68.
Turning now to Figure 3, there is shown therein a filtering and concen~ration apparatus utilizing the filteL 10.
An inlet line 72 is connected between the inlet bore 60 and a reservoir 74 of liquld to be purified through a peristaltic pump 76. A first outlet line 78 is connected between the outlet bore 64 and the reservoir 74 while a second outllne line 80 is connected between the outlet bore 68 and a con-tainer 82.
In the operation of the filter 10 in the apparatus of Figure 3, two different modes are possible, namely a fil-tering mode and a concentxation mode, depending on the rela-tive dimension of the desired and undesired materials~ In the filtering mode, the liquid to be filtered containing the desired product and undesirable particulate matter of different dimensions from the desired product, which may have a wide size range, fr~m 20 M~ to 1 mm., is pumped by the pump 76 from the reservoir 74 containing ~he liquid to be filtered to the inlet bore 60 of the filter 10.
The liquid enters the parallel fluid flow paths 54 and flow across the filter medium 37 towards the outlet bore 64 at the opposite end of the fl-~id flow paths54. The pore size of the filter membrane 40 is chosen to reject the un-desirable particulates but to permit passage of the desired dissolved and particulate material therethrough.
As the liquid flows across the filter medium 37 along the fluid flow paths 54, a portion of the liquid phase passes through the filter membrane 40 into the corresponding fluid flow path 58 on the opposite side of the filter medium 40. The ou~let bore 68 collects the permeate in parallel from the flow paths 58 and the permeate flows by outline line 80 to the per-meate reservoir 82.
The remaining liquid of higher concentration of par-ticulate waste is collected from the flow paths 54 by outlet bore 64 and is passed by line 78 to the reservoir 74. The procedure is repeated until the permeate contains all the material desired to be passed through the filter membrane 50.
Additional aqueous solvent may be added to the reservoir 74 if permeate recovery becomes difficult at high solids con-centrations.
In the concentration mode, the filter membrane 40 is chosen to reject the desirable particulates while permitting undesirable particulates and dissolved materials to pass therethrough. In this case, the liquid from the reservoir 74 5 is pumped from the inlet 60 to the outlet 64 and back to the reservoir 74 and is purified in its flow through the filter 10 by passage of part of the liquid, particulates and dissolved solids through the filter membrane 40. The latter material passes out of the filter 10 through outlet bore 68 by line 80 10 to a drain 82.
The concentration may be continued until the pump runs dry, so that the volume remaining is that contained in the flow paths 54 and the tubing. This volume is readily recovered and fed back to the reservoir 74 by the use of inert gas. The 15 final concentration may be controlled from this mimimum to any desired level by the addition of pure solvent or by stopping the concentration at any desired point.
The concentrated liquid may be purified further by adding pure solvent to the reservoir 7~ and continuing con-20 centration until the desired purity is achieved.
The filter 10 provided in accordance with this inven-tion is of relatively simple construction and is relatively in-expensive to manufacture and operate. The filter 10 is able to accept very high concentrations of particulates and 25 particulates up to 1 mm in size do not clog the filter operation.
The filter 10 may use filter membr~ne, of varying pore size to achieve filtration or concentration of desired fluid, as needed. Little turbulenc~ is involved in -the fluid flow, so that delicate microorganisms or particulates are 30 readil~ handled. A wide range of material of construction may be used and a wide range of filter dimensions is possible.
In summary of this disclosure, the present invention provides a filter unit in which fluid flow occurs across the face of the filter element housed in a flat rectangular 35 housing to achieve efficient fi:Ltration in a simple and inex-pensive manner. Modifications are possible within the scope of this invention.
_ Th~ pres~nt invention relates to a filter housing ~or holding linear tangential membrane filters.
There are many instances where separation of a desired 5 microorganism or dxug from impurities is required to be effected, especially in the production o IV fluids, insulin, viral and bacterial vaccines and other drugs in pure form. The prior art has made several approaches to this purification problem and none has been entirely satisfactory.
One prior art approach is the use of chemical absorp-tion and adsorption but such procedures are expensive and occasionally introduce toxicity to the product, thereby causing advèrse reaction when administered. Centrifugation has been used with excellent results but the cost of equipment and 15 operation is very highO
Straight through filtration is another approach but suffers from the drawback that there is a low throughput and a low recovery. Stralght through filtration is suitable only for final filtration when, for example, microorganisms must be removed from a liquid with moderate levels of suspended solids.
Tangential filter membrane holders are known and have shown promising results. However, the circular design of such holders limlts the utility to laboratory testing and research applications where only small volumes are filtered.
A yet further prior art approach is the utilization o ultrafiltration in the form of casettes, spiral wound cartridges, hollow tube cartridges, hollow fiber cartridges and plate and frame types. A11 but the hollow tube cartridge clog up when particulate concentration is high and/or when particu-late sizes exceed 5 microns. However, the hollow tube cartridge has not been developed for pharmaceutical applica-tions, where a high level of residue-free sanitation and/or sterilization are required. In addition, ultrafiltration cartridges are limited in pore size, membrane material and flow pattern-The prior art, therefore, suffers the major disadvan-~f~36 tages of cost and toxic side effects, along with other problems,such as, space requirement, inflexibility, high energy use, sophis~icated equlpment operation and product loss.
In accordance with the present invention, there is provided a novel filter which enables the defects of the prior art to be overcome and enables purification of biological fluids to be attained in a simple, inexpensive and low energy requirement manner.
The filter of the present invention comprlses upper and lower generally planar and rectangulax housing portions -~hich are releasably joined together and define a cavity therein.
A planar filter medium spans the cavity and is supported therein to separate the cavity into two fluid flow zones. Each of the fluid flow zones is separated into a plurality of parallel fluid flow paths extending from one end to the other, with each flow path being of essentially uniform cross-sectional flow area.
An lnlet communicates in parallel with the fluid flow paths in one only of the fluid flow zones at one end thereof and a first outlet communicates in parallel with the same fluid flow paths at the other end thereof. A second outlet communicates in parallel with the fluid flow paths only in the other of the fluid flow path zones.
Liquid to be concentrated or filtered is flowed from the inlet along the fluid flow paths in the one fluid flow zone 25 across the face of the filter medium~ Some liquid, dissolved material and particulates pass through the filter medium int-.
the fluid flow p~ths in the other of the fluid flow zones and flo~ out of the second outlet r while the remainder of the liquid, dissolved material and particulates flow out of the 30 first outlet. Depending on the pore size of the filter membrane and the relative particle sizes of the desired or undesired materials~ desired materials may be filtered and collected as the permeate or may be concentrated.
The invention is described further, by way of illustration, 3~ with reference to the accompanying drawings, in which:
Figure 1 is a perspective view, with parts cut-away for clarity, of a filter in accordance with one preferred embodiment of the invention;
Figure 2 is a sectional view of the ~ilter housing 40 taken on line 2-2 of Figure l; and Figure 3 is a schematic xepresenta-tion oE a filtra-tion apparatus embodying the filter housing of Figures 1 and Referring first to Figures 1 and 2 of the drawings, 5 which illustrate the current best mode of the invention known to the applican~, a filter 10 is provided. The filter 10 is generally planar and of rectangular shape and includes an upper housing portion 12 and a lower housing portion 14 joined together by any suitable means, such as bolts 16.
The lower housing portion 14 has an integral upstand-ing wall member 18 extending perimetrically adjacent the outer perimeter of the lower housing portion 14. The upper surface 20 of -the w?ll 18 has a groove 22 therein in which is seated a sealing O-ring 24.
The wall 18 acts as a spacing element and receives a perimeter surface 26 of the upper housing portion 12 in engage-ment with the upper surface 20 of the wall 18 when the housing 10 is assembled, the O-ring 24 providing a fluid tight seal in the area of engagement.
The upper housing portion 12 has an integral upstand-ing wall member 28 extending perimetrically immediately adjacent to and defining the inner extremity of the perimeter surface 26 and-having a lower surface 30. When the upper housing portion 12 is assembled with the lower portion 14 the 25 wall member 28 extends downwardly in engagement with the wall member 18 towards an annular surface 32 of the lower lousing portion 14, which has a sealing O-ring 34 seated in a groove 36 formed therein.
Mounted between lower surface 30 of the wall 28 and 30 the annular surface 32 is a filter medium 37 consisting of a porous filter support plate 38 and a filter membrane 40. The filter support plate 38 may be of any convenient construction to permit fluid flow therethrough while supporting the filter membrane 40. The filter membrane 40 may be of any convenient 35 type having pore sizes sufficient to achieve the desired fil-trationO For example, Millipore Corporation manufacture and sell a line of filter membranes of differing pore size from 10,000 NMWL to 8 microns, which are suitable for use in the filter lO.
A cavity 42 is deined in the interior of the filter lO by a recessed inner surface 44 in the lower housing portion 14 whi.ch is spaced from the inner surface 46 of the 5 upper housing portion 12. The filter medium 37 spans the cavity 42 and separates the same into a lower fluid flow zone 48 and an upper fluid flow zone 50.
Upstanding from and integral with the recessed surface 44 are spaced ribs 52 which extend in parallelism from 10 one end of the recessed surface 44 to the other. The ribs 52 extend upwardly into engagement with the underside of the filter medium ~7to separate the lower fluid flow zone 48 into three parallel flow paths 54.
Similarly, upstanding from and integral with the inn~r 15 surface 46 of the upper housing portion 12 are spaced ribs 56 which extend in parallelism from one end of the surface 46 to the other. The ribs 56 extend downwardly coplanarly with the corresponding ribs 52 and into engagement with the topside of the ~ilter medium 37to sand~ich t~e filter medium 37 between 20 the ribs 52 and 56 and to separate the upper fluid flow zone 48 into three parallel flow paths 58.
~ n inlet bore 60 extends from one side of the lower housing portion 14 towards the other and communicates in parallel with the flow paths 54 through depressions 62 in the 25 recessed surf~ce 44 which intersect the inlet bore 60.
An outlet bore 64 extends from the sa~e side of the lower housing portion 14 towards the other and communicates in parallel with the flow paths 54 through depressions 66 in the recessed surface 44 which intersect the outlet bore 64. If 30 desired, the outlet bore 64 may extend from the other side of the lower housing portion 14 from the inlet bore 62.
A second outlet bore 68 extends from one side of the upper housing portion 12 towards the other at approximately the midpoint of the length thereof so as to avoid inter-35 ference of the flow line therefrom with those communicatingwith bores 60 and 64~ The outlet bore 68 communicates in parallel with the flow paths 58 through grooves 70 cut into the inner surface 46 of the upper housing portion 12 and intersec~ng the bore 68.
Turning now to Figure 3, there is shown therein a filtering and concen~ration apparatus utilizing the filteL 10.
An inlet line 72 is connected between the inlet bore 60 and a reservoir 74 of liquld to be purified through a peristaltic pump 76. A first outlet line 78 is connected between the outlet bore 64 and the reservoir 74 while a second outllne line 80 is connected between the outlet bore 68 and a con-tainer 82.
In the operation of the filter 10 in the apparatus of Figure 3, two different modes are possible, namely a fil-tering mode and a concentxation mode, depending on the rela-tive dimension of the desired and undesired materials~ In the filtering mode, the liquid to be filtered containing the desired product and undesirable particulate matter of different dimensions from the desired product, which may have a wide size range, fr~m 20 M~ to 1 mm., is pumped by the pump 76 from the reservoir 74 containing ~he liquid to be filtered to the inlet bore 60 of the filter 10.
The liquid enters the parallel fluid flow paths 54 and flow across the filter medium 37 towards the outlet bore 64 at the opposite end of the fl-~id flow paths54. The pore size of the filter membrane 40 is chosen to reject the un-desirable particulates but to permit passage of the desired dissolved and particulate material therethrough.
As the liquid flows across the filter medium 37 along the fluid flow paths 54, a portion of the liquid phase passes through the filter membrane 40 into the corresponding fluid flow path 58 on the opposite side of the filter medium 40. The ou~let bore 68 collects the permeate in parallel from the flow paths 58 and the permeate flows by outline line 80 to the per-meate reservoir 82.
The remaining liquid of higher concentration of par-ticulate waste is collected from the flow paths 54 by outlet bore 64 and is passed by line 78 to the reservoir 74. The procedure is repeated until the permeate contains all the material desired to be passed through the filter membrane 50.
Additional aqueous solvent may be added to the reservoir 74 if permeate recovery becomes difficult at high solids con-centrations.
In the concentration mode, the filter membrane 40 is chosen to reject the desirable particulates while permitting undesirable particulates and dissolved materials to pass therethrough. In this case, the liquid from the reservoir 74 5 is pumped from the inlet 60 to the outlet 64 and back to the reservoir 74 and is purified in its flow through the filter 10 by passage of part of the liquid, particulates and dissolved solids through the filter membrane 40. The latter material passes out of the filter 10 through outlet bore 68 by line 80 10 to a drain 82.
The concentration may be continued until the pump runs dry, so that the volume remaining is that contained in the flow paths 54 and the tubing. This volume is readily recovered and fed back to the reservoir 74 by the use of inert gas. The 15 final concentration may be controlled from this mimimum to any desired level by the addition of pure solvent or by stopping the concentration at any desired point.
The concentrated liquid may be purified further by adding pure solvent to the reservoir 7~ and continuing con-20 centration until the desired purity is achieved.
The filter 10 provided in accordance with this inven-tion is of relatively simple construction and is relatively in-expensive to manufacture and operate. The filter 10 is able to accept very high concentrations of particulates and 25 particulates up to 1 mm in size do not clog the filter operation.
The filter 10 may use filter membr~ne, of varying pore size to achieve filtration or concentration of desired fluid, as needed. Little turbulenc~ is involved in -the fluid flow, so that delicate microorganisms or particulates are 30 readil~ handled. A wide range of material of construction may be used and a wide range of filter dimensions is possible.
In summary of this disclosure, the present invention provides a filter unit in which fluid flow occurs across the face of the filter element housed in a flat rectangular 35 housing to achieve efficient fi:Ltration in a simple and inex-pensive manner. Modifications are possible within the scope of this invention.
Claims (7)
1. A filter, comprising:
upper and lower generally planar and rectangular housing portions releasably joined together and defining a filter housing having a cavity therein, planar filter medium means extending coextensively with said cavity and supported by said housing portions in said cavity, said planar filter medium means separating said cavity into upper and lower fluid flow zones, means defining a plurality of parallel fluid flow paths, each path being of essentially uniform cross-sectional flow area, said flow path being within each of said fluid flow zones and extending from one end thereof to the other end thereof, inlet means communicating in parallel with said fluid flow paths only in said lower fluid flow zone at said one end of said lower fluid flow zone, first outlet means communicating in parallel with said fluid flow paths only in said lower fluid flow zone at the other end thereof, and second outlet means communicating in parallel with said fluid flow paths only in said upper fluid flow zone.
upper and lower generally planar and rectangular housing portions releasably joined together and defining a filter housing having a cavity therein, planar filter medium means extending coextensively with said cavity and supported by said housing portions in said cavity, said planar filter medium means separating said cavity into upper and lower fluid flow zones, means defining a plurality of parallel fluid flow paths, each path being of essentially uniform cross-sectional flow area, said flow path being within each of said fluid flow zones and extending from one end thereof to the other end thereof, inlet means communicating in parallel with said fluid flow paths only in said lower fluid flow zone at said one end of said lower fluid flow zone, first outlet means communicating in parallel with said fluid flow paths only in said lower fluid flow zone at the other end thereof, and second outlet means communicating in parallel with said fluid flow paths only in said upper fluid flow zone.
2. The filter claimed in claim 1 wherein said filter medium means comprises filter support means and filter membrane means.
3. The filter claimed in claim 1 wherein said upper and lower housing portions include cooperating portions which clamp the periphery of said filter medium means therebetween, thereby to support said filter medium means in said cavity.
4. The filter claimed in claim 1, 2 or 3 wherein said means defining a plurality of parallel fluid flow paths com-prises parallel rib members extending within the cavity and upstanding respectively from the cavity-defining surfaces of said upper and lower housing portions and extending in planar aligned pairs into engagement with opposite sides of said filter medium means.
5. The filter claimed in claim 1, 2 or 3 wherein said means defining a plurality of parallel fluid flow paths comprises parallel rib members extending within the cavity and upstanding respectively from the cavity-defining surfaces of said upper and lower housing portions and extending in planar aligned pairs into alignment with opposite sides of said filter medium means, said inlet means comprises a first bore extending from one side of said lower housing portion at said one end of said cavity and first fluid flow channels in each of said fluid flow paths in said lower fluid flow zone intersecting said first bore, and said first outlet means comprises a second bore extending from one side of said lower housing portion at said other end of said cavity and second fluid flow channels in each of said fluid flow paths in said lower fluid flow zone intersecting said second bore.
6. The filter of claim 1,2 or 3 wherein said means defining a plurality of parallel fluid flow paths comprises parallel rib members extending within the cavity and upstanding respectively from the cavity-defining surfaces of said upper and lower housing portions and extending in planar aligned pairs into alignment with opposite sides of said filter medium means, said inlet means comprises a first bore extending from one side of said lower housing portion at said one end of said cavity and first fluid flow channels in each of said fluid flow paths in said lower fluid flow zone intersecting said first bore, said first outlet means comprises a second bore extending from one side of said lower housing portion at said other end of said cavity and second fluid flow channels in each of said fluid flow paths in said lower fluid flow zone intersecting said second boreo, and said second outlet means comprises a third bore extending from one side of said upper housing portion and third fluid flow channels in each of said fluid flow paths in said upper fluid flow zone intersecting said third bore.
8a
8a
7. The filter of claim 1, 2 or 3, wherein said means defining plurality of parallel fluid flow paths comprises parallel rib members extending within the cavity and upstanding respectively from the cavity-defining surfaces of said upper and lower housing portions and extending in planar aligned pairs into alignment with opposite sides of said filter medium means, said inlet means comprises a first bore extending from one side of said lower housing portion at said one end of said cavity and first fluid flow channels in each of said fluid flow paths in said lower fluid flow zone intersecting said first bore, said first outlet means comprises a second bore extending from one side of said lower housing portion at said other end of said cavity and second fluid flow channels in each of said fluid flow paths in said lower fluid flow zone intersecting said second bore, said second outlet means comprises a third bore extending from one side of said upper housing portion and third fluid flow channels in each of said fluid flow paths in said upper fluid flow zone intersecting said third bore, and said third bore is located at approximately the midpoint of the length of said cavity between said first and second bores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22448181A | 1981-01-12 | 1981-01-12 | |
| US224,481 | 1981-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1181696A true CA1181696A (en) | 1985-01-29 |
Family
ID=22840890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000393836A Expired CA1181696A (en) | 1981-01-12 | 1982-01-08 | Filter |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1181696A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107952280A (en) * | 2017-11-28 | 2018-04-24 | 安徽东方帝维生物制品股份有限公司 | A kind of live vaccine sterile ultrafiltration enrichment facility and method |
-
1982
- 1982-01-08 CA CA000393836A patent/CA1181696A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107952280A (en) * | 2017-11-28 | 2018-04-24 | 安徽东方帝维生物制品股份有限公司 | A kind of live vaccine sterile ultrafiltration enrichment facility and method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5762789A (en) | Disposable membrane module with low-dead volume | |
| US6294090B1 (en) | Adsorptive substance separation device | |
| JP3924926B2 (en) | Hollow fiber membrane filtration membrane module | |
| JPH0361483B2 (en) | ||
| US7404493B2 (en) | Filter device including pleated filter incorporated in a housing | |
| US4244820A (en) | Fluid purification system | |
| US5102545A (en) | Tubular filter element | |
| US10935474B1 (en) | Membrane filter device | |
| US5240605A (en) | Spiral filter | |
| EP0296881B1 (en) | Multi-leaf permeable membrane module | |
| CA1181696A (en) | Filter | |
| US4869822A (en) | Filter apparatus employing hollow fibers | |
| CN211445261U (en) | High efficiency ceramic membrane solid-liquid separation machine | |
| US11203537B1 (en) | Method for filtering liquid mixture | |
| JPH0768137A (en) | Separation membrane module | |
| JP2004524140A5 (en) | ||
| JP2000517240A (en) | Filtration unit with pleated filter element | |
| JPS6320003A (en) | Precision filter | |
| JPH11300175A (en) | Fluid medium filtering and separating device having at least one permeated material outlet | |
| CN207970579U (en) | A kind of pressure filter | |
| Tanny et al. | Filtration of particulates and emulsions with a pleated, thin channel, cross-flow module | |
| JPH04190835A (en) | Cross-flow type filter | |
| JPH0386218A (en) | Hollow-fiber membrane module | |
| KR20210008570A (en) | Fixed rigid wall device for compressed pleat configuration filters | |
| JP2000070683A (en) | Hollow fiber membrane type permeation membrane module |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |