CA1123792A - Mercury sealable plug - Google Patents
Mercury sealable plugInfo
- Publication number
- CA1123792A CA1123792A CA282,025A CA282025A CA1123792A CA 1123792 A CA1123792 A CA 1123792A CA 282025 A CA282025 A CA 282025A CA 1123792 A CA1123792 A CA 1123792A
- Authority
- CA
- Canada
- Prior art keywords
- vessel
- septum
- passageway
- neck
- sealing device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A sealing device, i.e., a mercury sealable plug, for a neck of a vessel is disclosed. The sealing device comprises a body having a first end and a second end; the first end being adapted to face outwardly from the neck of the vessel and the second end being adapted to be within the vessel. The body has a longitudinal passageway running therethrough with outlets at the first and second ends of the body. Two annular grooves in the outer side surface of the body are adapted to contain two annular rings capable of providing a seal with the inner surface of the neck of the vessel. The outlets at the first and second ends of the body are adapted to be closed by first and second septums respectlvely. The passageway and an annular space defined by the two rings, the outer surface of the body and the inner surface of the neck are adapted to contain mercury to seal the vessel opening in such a way that any contents of the vessel may be sampled by means of a syringe needle through the first septum, the passageway and the second septum over an extended period of time without gases diffusing to or from the vessel between samplings. In an embodiment of the sealing device, at least one channel leads from the passageway to the outer side surface of the body between the two annular grooves. The channel is also adapted to contain mercury and to connect the passageway to the annular space.
A sealing device, i.e., a mercury sealable plug, for a neck of a vessel is disclosed. The sealing device comprises a body having a first end and a second end; the first end being adapted to face outwardly from the neck of the vessel and the second end being adapted to be within the vessel. The body has a longitudinal passageway running therethrough with outlets at the first and second ends of the body. Two annular grooves in the outer side surface of the body are adapted to contain two annular rings capable of providing a seal with the inner surface of the neck of the vessel. The outlets at the first and second ends of the body are adapted to be closed by first and second septums respectlvely. The passageway and an annular space defined by the two rings, the outer surface of the body and the inner surface of the neck are adapted to contain mercury to seal the vessel opening in such a way that any contents of the vessel may be sampled by means of a syringe needle through the first septum, the passageway and the second septum over an extended period of time without gases diffusing to or from the vessel between samplings. In an embodiment of the sealing device, at least one channel leads from the passageway to the outer side surface of the body between the two annular grooves. The channel is also adapted to contain mercury and to connect the passageway to the annular space.
Description
lJ ~ 3 ;'~ ~
- m is inventlon rel~te~ to a sealing devlce for a neck of a ve~sel which permlt8 acce9s to the contents of vessel by means of a ~yringe needle while provlding an effective seal against long-term gaseous diffuslon to or rrom the vessel.
Sealing devices for fl neck of a vessel which permit access to the contents o~ the vessel by means of a syringe needle are kno~nnin the art. However, such seal-ing devlce~ generally consi~t of septum3 o~ one or more layers o~ elastomerlc material. The elastomeric material provides an adequate seal against gasecuæ dlffuslon to or Prom a vessel for short periods e.g. less than a ~eek. How-ever, where the contents of the ve~sel are to be sampled by a ~yringe needle o~er long periods e.g. greater than one month, gaseous dlffuslon through the elastomeric materlal may become a problem. For example, ln a study of the degradatlon of polyethylene in air at room temperature over a period of several months in a ve~sel closed by a æealing device comprlsing septums of elastomeric materlal, dif~uælon of oxygen (from air) through the elastomeric material lnto the ~essel was sufficiently rapid to completely obscure any change ln the oxygen content of the vessel as a re~ult of degradation o~
the polyethylene.
It is an ob~ect of the present lnventlon to provlde a sealing device for a neck of a vessel which permits access to the content~ of the vessel by means of a æyringe needle while providing an ef~ective seal agalnst gaseou3 di~usion to or from the vessel over long perlods of tlme.
It has now been found that such a sealing devlce may be provided if mercury ls utilized between septums as 1~.237~2 a sealing medium.
Accordingly, the present inventlon provldes a sealing dev~ce for a neck of a vessel, comprising:
a body having a first end and a second end, the first end being adapted to face outwardly from the neck of the vessel and the second end being adapted to be wlthin the vessel, a pa~sageway running longitudlnally through the body and having an outlet at the first end and at the second end, two spaced annular grooves in the outer side sur~ace of the body, the grooves bein8 adapted to contain two annular rings capable of providing a seal with the inner surface - of the neck of the vessel, the outlet at the first end of the body being adapted to be closed by a flrst septum, the outlet at the second end of the body being adapted to be closed by a second septum, the passageway and an annular space defined by the two rings, the outer side surface of the body and the lnner surface of the neck being adapted to contain mercury to seal the ve~sel neck in such a way that any contents of the vessel may be sampled by means of a syringe needle through the first septum~ the passageway and the second septum over an extended period of time without gases diffusing to or from the vessel between samplin~s.
In an embodiment of the present invention, the sealing device lncludes at least one channel leading from the passageway to the outer side surface of the body between the two annular grooves, the channel also being adapted to , 30 contain mercury and to connect the passageway to the annular space.
- m is inventlon rel~te~ to a sealing devlce for a neck of a ve~sel which permlt8 acce9s to the contents of vessel by means of a ~yringe needle while provlding an effective seal against long-term gaseous diffuslon to or rrom the vessel.
Sealing devices for fl neck of a vessel which permit access to the contents o~ the vessel by means of a syringe needle are kno~nnin the art. However, such seal-ing devlce~ generally consi~t of septum3 o~ one or more layers o~ elastomerlc material. The elastomeric material provides an adequate seal against gasecuæ dlffuslon to or Prom a vessel for short periods e.g. less than a ~eek. How-ever, where the contents of the ve~sel are to be sampled by a ~yringe needle o~er long periods e.g. greater than one month, gaseous dlffuslon through the elastomeric materlal may become a problem. For example, ln a study of the degradatlon of polyethylene in air at room temperature over a period of several months in a ve~sel closed by a æealing device comprlsing septums of elastomeric materlal, dif~uælon of oxygen (from air) through the elastomeric material lnto the ~essel was sufficiently rapid to completely obscure any change ln the oxygen content of the vessel as a re~ult of degradation o~
the polyethylene.
It is an ob~ect of the present lnventlon to provlde a sealing device for a neck of a vessel which permits access to the content~ of the vessel by means of a æyringe needle while providing an ef~ective seal agalnst gaseou3 di~usion to or from the vessel over long perlods of tlme.
It has now been found that such a sealing devlce may be provided if mercury ls utilized between septums as 1~.237~2 a sealing medium.
Accordingly, the present inventlon provldes a sealing dev~ce for a neck of a vessel, comprising:
a body having a first end and a second end, the first end being adapted to face outwardly from the neck of the vessel and the second end being adapted to be wlthin the vessel, a pa~sageway running longitudlnally through the body and having an outlet at the first end and at the second end, two spaced annular grooves in the outer side sur~ace of the body, the grooves bein8 adapted to contain two annular rings capable of providing a seal with the inner surface - of the neck of the vessel, the outlet at the first end of the body being adapted to be closed by a flrst septum, the outlet at the second end of the body being adapted to be closed by a second septum, the passageway and an annular space defined by the two rings, the outer side surface of the body and the lnner surface of the neck being adapted to contain mercury to seal the ve~sel neck in such a way that any contents of the vessel may be sampled by means of a syringe needle through the first septum~ the passageway and the second septum over an extended period of time without gases diffusing to or from the vessel between samplin~s.
In an embodiment of the present invention, the sealing device lncludes at least one channel leading from the passageway to the outer side surface of the body between the two annular grooves, the channel also being adapted to , 30 contain mercury and to connect the passageway to the annular space.
- 2 -,, 1~.237~Z
In another embodiment of the present lnventlon, the two annular rings, the first septum and the second septum are made of an elastomeric material.
In yet another embodiment, the body of the sealing device is made of ~talnless steel.
In a further embodiment the two annular rings, the first septum and the second septum are made of silicone rubber.
An embodiment of the invention is illustrated by reference to the accompanying drawings in which:
Fig. 1 is a hal~ section view of a sealing device according to one embodlment of the present invention sho~n positioned in a neck of a vessel (not shown).
Fig. 2 i~ a section view of the embodiment of Fig. 1 ~; viewed in the directlon of arrows II-II ln Fig. 1.
Fig. 3 is a plot of the ratlo of the areas of peak3 on a gas chromatograph for oxygen and nltrogen wlth time, in hours, for gas samples sealed in sample tubes u~ing the sealing device of the present invention, and for comparison using a sealing devlce that did not contain mercury.
In Figures 1 and 2, a sealing device according to one embodlment of the present invention is designated generally by the numeral 10 and is shown mounted in a neck 11 of a vessel (not shown). me sealing device 10 has a body 12. Body 12 has a first end faclng outwardly from neck 11 of the vessel and a second end withln the vessel. A passageway 13 runnlng longitudinally through body 12 has an outlet 14 at the flrst end and an outlet 15 at the second end. Two annular grooves 16 in the outer side surface of body 12 each contain an annular ring 17 which seals agalnst the inner surface of the neck 11. Six channels 18 (see Fig. 2) lead from the ~ Z 3~ ~2 pasRageway 13 to the outer surface of the body 12 between the two annular grooves 16. A first ~eptum 19J held ln posi-tlon by an aluminum cap 20 having an open~ ng 21 therein cover~
the outlet 14 in the first end of body 12. It wlll be appre-ciated that the alumlnum cap 20 may be omitted or that other means to hold the first septum 19 in position may be substituted therefor. A second septum 22, which ls recessed into the body 12 and held in position by a threaded plug 23, covers the outlet 15 at the second end of body 12. A pas~age 24 runs axially through threaded plug 23. It will be appreciated that means other than threaded plug 23 may be used to hold the ~econd septum 2~ ln posltlon. me passageway 13 (between first æeptum 19 and second septum 22), the channels 18 and the annular space defined by the two annular rings 17, the outer surface of body 12 and the inner surface of the neck 11 are full of mercury.
In operation, the sealing device 10, with the first septum 19 and the aluminum cap 20 removed, iB positioned in the nec~ 11 of a vessel, the contents of which are to be sampled repeatedly o~er an extended period of time by mean~
of a syringe needle. Mercury is poured into the passageway 13, from which it flows through the six channels 18 into the annular space def~ned by the two annular rings 17~ the outer slde surface o~ body 12 and the inner surface of the neck 11 of the vessel. It will be appreciated that the number o~
channels 18 ls not critical, for example, one channel may be sufflclent to allow the mercury to flow from the passageway 13 into the annular space. Under some conditions, for example, where sampling is being carrled out very frequently over an extended period o~ time it may be de~irable to ellminate channels 18 entirely. In these circum~tances mercury i~ added to the annular space by means of a syringe needle which i8 paBBed ` 13~ 237~Z
through the upper annular ring 17. A syringe needle i8 also used to remove air trapped between the mercury and the upper annular ring l? during the addltion of the mercury. When the passageway 13 is full of mercury, the first septum 19 i8 po~itioned o~er the outlet 14 of channel 13 and held ln position by the aluminum CQp 20.
In sampling the vessel contents, a ~yrlnge needle i5 pas~ed in series through: the ~pening 21 ~n the aluminum cap 20; the ~irst septum 19; the passageway 13; the second septum 22; and the passage 24 of the threaded plug 23; into the vessel. The presence of the mercury in the passageway 13 and in the annular space defined by the two annular rings 17, the outer slde surface of body 12 and the inner ~urface of the neck 11 of the vessel, make~ it possible to sample the vessel content~ repeatedly over extended periods of time, e.g.
several months, without any gases diffusing to or from the vessel between samplings.
In lnstances where, during the sampl~ng perlod, the neck 11 of the vessel may be positioned for any extended period of time ln a near horizontal posltion, it is important that the passageway 13 remain full of mercury (to en~ure that the annular space between annular rings 17 remains sealed with mercury3. On each sampling o~ the vessel contents, a small quantity of mercury may escape through the flrst septum 19 with the syringe needle a~ it is withdrawn therefrom.
Thus, where sampling is to be carried out very frequently over an extended period~ it may be desirable to add mercury to passageway 13 occasionally during the sampling period. me mercury may be added through first septum 19 by means of a syringe needle. Alternatively, the problem of ensuring that th0 annular space between annular rings 17 remains sealed ~.237~2 with mercury may be solved by the ellmination of channels 18 as described heretofore.
The body 12 may be made from any suitable material, for example metal, which ls inert to mercury and to the vessel contents and is impermeable to gases. A preferred material for the body 12 is ~tainless steel.
The two annular rlng~ 17, the first septum 19 and the second septum 22 may be made from any sultable material whlch wlll allow passage of a syringe needle therethrough and which is resilient anough to keep to a mlnimum any leakage of mercury which may occur when the syringe needle ls withdrawn therefrom. Preferred materials are elastomeric materials and a more preferred material is silicone rubber.
The present invention is illustrated by the following example.
EXA~PLE
Two sealing devices accordlng to the present invention as illustrate~d in Flguree 1 and 2 were mounted in ~eparate sample tubes, one containing a gas mixture of 15% o~ygen, by welght, ln nitrogen and the other containing a gas mixture of 24% oxygen, by welght, in nitr~gen. Two other sealing devices identical to the one illustrated ln Figures 1 and 2 except that the mercury has been omitted from the sealing devices were mounted ln two other sample tubes, one containing a gas mlxture of 15~ oxygen, by weight, in nitrogen and the other containing a gas mixtl~e of 24%
oxygen, by weight, in nitrogen.
In each of the above four sealing devices, the body 12 and the plug 23 were made of stainless steel and the two annular rings 17, the flrst septum 19 and the ~econd septum 22 were made of silicone rubber.
1~.23~2 The ~our sample tubes were stored for an extended perlod of time, Sample o~ the gas m~xture in each sample tubo were taken periodically with a syrlnge needlc, as herein-above described, and analyzed uslng a ga~ chromatosr6ph, - In Figure 3, the ratlo of the areas of peaks on a ga~ chromatograph for oxygen and nltrogen for the gas mixture in each sample tube is plotted versus time in hours. m e ratio of the areas under the respective peak~ on the gas chromatograph ls indlcative o~ the amount of oxygen present in the tubes. In the absence of diffuslon of oxygen and/or nitrogen through tho sealing de~lce~, lt would be anticipated that the ratio of the peak areas for oxygen :nltrogen would rema~n constant throughout the sampling perlod, The curves in Flgure 3 may be ldentif$ed as follows:
(1) the closed ~quares - lndlcate samples ~rom the sample tube initlally contain~ng 15% by weight of cxygen and closed by the seallng devlce of the pre~ent in~entlon;
(2) the closed circles - indicate samples from the sa~ple tube inltlally containing 24% by weight of oxygen ~nd closed by the sealing de-; vice Or the present inve~tion;
In another embodiment of the present lnventlon, the two annular rings, the first septum and the second septum are made of an elastomeric material.
In yet another embodiment, the body of the sealing device is made of ~talnless steel.
In a further embodiment the two annular rings, the first septum and the second septum are made of silicone rubber.
An embodiment of the invention is illustrated by reference to the accompanying drawings in which:
Fig. 1 is a hal~ section view of a sealing device according to one embodlment of the present invention sho~n positioned in a neck of a vessel (not shown).
Fig. 2 i~ a section view of the embodiment of Fig. 1 ~; viewed in the directlon of arrows II-II ln Fig. 1.
Fig. 3 is a plot of the ratlo of the areas of peak3 on a gas chromatograph for oxygen and nltrogen wlth time, in hours, for gas samples sealed in sample tubes u~ing the sealing device of the present invention, and for comparison using a sealing devlce that did not contain mercury.
In Figures 1 and 2, a sealing device according to one embodlment of the present invention is designated generally by the numeral 10 and is shown mounted in a neck 11 of a vessel (not shown). me sealing device 10 has a body 12. Body 12 has a first end faclng outwardly from neck 11 of the vessel and a second end withln the vessel. A passageway 13 runnlng longitudinally through body 12 has an outlet 14 at the flrst end and an outlet 15 at the second end. Two annular grooves 16 in the outer side surface of body 12 each contain an annular ring 17 which seals agalnst the inner surface of the neck 11. Six channels 18 (see Fig. 2) lead from the ~ Z 3~ ~2 pasRageway 13 to the outer surface of the body 12 between the two annular grooves 16. A first ~eptum 19J held ln posi-tlon by an aluminum cap 20 having an open~ ng 21 therein cover~
the outlet 14 in the first end of body 12. It wlll be appre-ciated that the alumlnum cap 20 may be omitted or that other means to hold the first septum 19 in position may be substituted therefor. A second septum 22, which ls recessed into the body 12 and held in position by a threaded plug 23, covers the outlet 15 at the second end of body 12. A pas~age 24 runs axially through threaded plug 23. It will be appreciated that means other than threaded plug 23 may be used to hold the ~econd septum 2~ ln posltlon. me passageway 13 (between first æeptum 19 and second septum 22), the channels 18 and the annular space defined by the two annular rings 17, the outer surface of body 12 and the inner surface of the neck 11 are full of mercury.
In operation, the sealing device 10, with the first septum 19 and the aluminum cap 20 removed, iB positioned in the nec~ 11 of a vessel, the contents of which are to be sampled repeatedly o~er an extended period of time by mean~
of a syringe needle. Mercury is poured into the passageway 13, from which it flows through the six channels 18 into the annular space def~ned by the two annular rings 17~ the outer slde surface o~ body 12 and the inner surface of the neck 11 of the vessel. It will be appreciated that the number o~
channels 18 ls not critical, for example, one channel may be sufflclent to allow the mercury to flow from the passageway 13 into the annular space. Under some conditions, for example, where sampling is being carrled out very frequently over an extended period o~ time it may be de~irable to ellminate channels 18 entirely. In these circum~tances mercury i~ added to the annular space by means of a syringe needle which i8 paBBed ` 13~ 237~Z
through the upper annular ring 17. A syringe needle i8 also used to remove air trapped between the mercury and the upper annular ring l? during the addltion of the mercury. When the passageway 13 is full of mercury, the first septum 19 i8 po~itioned o~er the outlet 14 of channel 13 and held ln position by the aluminum CQp 20.
In sampling the vessel contents, a ~yrlnge needle i5 pas~ed in series through: the ~pening 21 ~n the aluminum cap 20; the ~irst septum 19; the passageway 13; the second septum 22; and the passage 24 of the threaded plug 23; into the vessel. The presence of the mercury in the passageway 13 and in the annular space defined by the two annular rings 17, the outer slde surface of body 12 and the inner ~urface of the neck 11 of the vessel, make~ it possible to sample the vessel content~ repeatedly over extended periods of time, e.g.
several months, without any gases diffusing to or from the vessel between samplings.
In lnstances where, during the sampl~ng perlod, the neck 11 of the vessel may be positioned for any extended period of time ln a near horizontal posltion, it is important that the passageway 13 remain full of mercury (to en~ure that the annular space between annular rings 17 remains sealed with mercury3. On each sampling o~ the vessel contents, a small quantity of mercury may escape through the flrst septum 19 with the syringe needle a~ it is withdrawn therefrom.
Thus, where sampling is to be carried out very frequently over an extended period~ it may be desirable to add mercury to passageway 13 occasionally during the sampling period. me mercury may be added through first septum 19 by means of a syringe needle. Alternatively, the problem of ensuring that th0 annular space between annular rings 17 remains sealed ~.237~2 with mercury may be solved by the ellmination of channels 18 as described heretofore.
The body 12 may be made from any suitable material, for example metal, which ls inert to mercury and to the vessel contents and is impermeable to gases. A preferred material for the body 12 is ~tainless steel.
The two annular rlng~ 17, the first septum 19 and the second septum 22 may be made from any sultable material whlch wlll allow passage of a syringe needle therethrough and which is resilient anough to keep to a mlnimum any leakage of mercury which may occur when the syringe needle ls withdrawn therefrom. Preferred materials are elastomeric materials and a more preferred material is silicone rubber.
The present invention is illustrated by the following example.
EXA~PLE
Two sealing devices accordlng to the present invention as illustrate~d in Flguree 1 and 2 were mounted in ~eparate sample tubes, one containing a gas mixture of 15% o~ygen, by welght, ln nitrogen and the other containing a gas mixture of 24% oxygen, by welght, in nitr~gen. Two other sealing devices identical to the one illustrated ln Figures 1 and 2 except that the mercury has been omitted from the sealing devices were mounted ln two other sample tubes, one containing a gas mlxture of 15~ oxygen, by weight, in nitrogen and the other containing a gas mixtl~e of 24%
oxygen, by weight, in nitrogen.
In each of the above four sealing devices, the body 12 and the plug 23 were made of stainless steel and the two annular rings 17, the flrst septum 19 and the ~econd septum 22 were made of silicone rubber.
1~.23~2 The ~our sample tubes were stored for an extended perlod of time, Sample o~ the gas m~xture in each sample tubo were taken periodically with a syrlnge needlc, as herein-above described, and analyzed uslng a ga~ chromatosr6ph, - In Figure 3, the ratlo of the areas of peaks on a ga~ chromatograph for oxygen and nltrogen for the gas mixture in each sample tube is plotted versus time in hours. m e ratio of the areas under the respective peak~ on the gas chromatograph ls indlcative o~ the amount of oxygen present in the tubes. In the absence of diffuslon of oxygen and/or nitrogen through tho sealing de~lce~, lt would be anticipated that the ratio of the peak areas for oxygen :nltrogen would rema~n constant throughout the sampling perlod, The curves in Flgure 3 may be ldentif$ed as follows:
(1) the closed ~quares - lndlcate samples ~rom the sample tube initlally contain~ng 15% by weight of cxygen and closed by the seallng devlce of the pre~ent in~entlon;
(2) the closed circles - indicate samples from the sa~ple tube inltlally containing 24% by weight of oxygen ~nd closed by the sealing de-; vice Or the present inve~tion;
(3) the open squares - lndlcate sample~ ~rom the sample tube lnltially contalning 15% by welght of oxygen and closed by Q sealine devlce from whlch mercury had been omitted;
(4) the open clrcles - ind~cate samples from the sample tube lnitially containing 24% by welght of oxygen and closed by a sealing device from which mercury had been omitted; and ~.23~?2
(5) the hori~ontal dotted line - indicates the arithmetic means obtained ~or measurements of the oxygen : nitrogen ratlos of a number of ~ir sample~ using the ga~ chromatograph.
From Figure 3 lt i 6 apparent that the gas compositions in the sample tubes sealed with the æealing devices without mercury approach the composition of air a~ter a period of about 2400 hours due to gas diffusion through the silicone rubber annular ringq 17 and/or through the silicone rubber first and ~econd septums 19 and 22, respectively.
It is al~o apparent ~rom Figure 3, that the gas compositions ln the sample tubes sealed wlth the sealing device o~ the present invention show no apparent change aiter a period o~ about 1800 to 2000 hours.
From Figure 3 lt i 6 apparent that the gas compositions in the sample tubes sealed with the æealing devices without mercury approach the composition of air a~ter a period of about 2400 hours due to gas diffusion through the silicone rubber annular ringq 17 and/or through the silicone rubber first and ~econd septums 19 and 22, respectively.
It is al~o apparent ~rom Figure 3, that the gas compositions ln the sample tubes sealed wlth the sealing device o~ the present invention show no apparent change aiter a period o~ about 1800 to 2000 hours.
Claims (7)
1. A sealing device for a neck of a vessel comprising:
a body having a first end and a second end, the first end being adapted to face outwardly from the neck of the vessel and the second end being adapted to be within the vessel, a passageway running longitudinally through the body and having an outlet at the first end and at the second end, two spaced annular grooves in the outer side surface of the body, the grooves being adapted to contain two annular rings capable of providing a seal with the inner surface of the neck of the vessel, the outlet at the first end of the body being adapted to be closed by a first septum, the outlet at the second end of the body being adapted to be closed by a second septum, the passageway and an annular space defined by the two rings, the outer side surface of the body and the inner surface of the neck being adapted to contain mercury to seal the vessel neck in such a way that any contents of the vessel may be sampled by means of a syringe needle through the first septum, the passageway and the second septum over an extended period of time without gases diffusing to or from the vessel between samplings.
a body having a first end and a second end, the first end being adapted to face outwardly from the neck of the vessel and the second end being adapted to be within the vessel, a passageway running longitudinally through the body and having an outlet at the first end and at the second end, two spaced annular grooves in the outer side surface of the body, the grooves being adapted to contain two annular rings capable of providing a seal with the inner surface of the neck of the vessel, the outlet at the first end of the body being adapted to be closed by a first septum, the outlet at the second end of the body being adapted to be closed by a second septum, the passageway and an annular space defined by the two rings, the outer side surface of the body and the inner surface of the neck being adapted to contain mercury to seal the vessel neck in such a way that any contents of the vessel may be sampled by means of a syringe needle through the first septum, the passageway and the second septum over an extended period of time without gases diffusing to or from the vessel between samplings.
2. The sealing device of Claim 1 including at least one channel leading from the passageway to the outer side surface of the body between the two annular grooves, the channel also being adapted to contain mercury and to connect the passageway to the annular space.
3. me sealing device of Claim 2 in which the two annular rings, the first septum and the second septum are made of an elastomeric material.
4. The sealing device of Claim 3 in which the body is made of stainless steel.
5. The sealing device of Claim 3 in which the second septum is recessed into the body and held in position by a threaded plug, a passage running axially through the threaded plug adapted to permit a syringe needle to be passed therethrough.
6. The sealing device of Claim 5 in which the first septum 18 held in position by an aluminum cap, an opening in the aluminum cap being adapted to permit a syringe needle to be passed therethrough.
7. The sealing device of any one of Claim 3, Claim 4 and Claim 6 in which the two annular rings, the first septum and the second septum are made of silicone rubber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA282,025A CA1123792A (en) | 1977-07-05 | 1977-07-05 | Mercury sealable plug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA282,025A CA1123792A (en) | 1977-07-05 | 1977-07-05 | Mercury sealable plug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1123792A true CA1123792A (en) | 1982-05-18 |
Family
ID=4109061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA282,025A Expired CA1123792A (en) | 1977-07-05 | 1977-07-05 | Mercury sealable plug |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA1123792A (en) |
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| US7032631B2 (en) | 2000-02-11 | 2006-04-25 | Medical Instill Technologies, Inc. | Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial |
| US7100646B2 (en) | 2000-02-11 | 2006-09-05 | Medical Instill Technologies, Inc. | Sealed containers and methods of making and filling same |
| US7243689B2 (en) | 2000-02-11 | 2007-07-17 | Medical Instill Technologies, Inc. | Device with needle penetrable and laser resealable portion and related method |
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| US9668914B2 (en) | 2000-10-23 | 2017-06-06 | Dr. Py Institute Llc | Method for dispensing ophthalmic fluid |
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-
1977
- 1977-07-05 CA CA282,025A patent/CA1123792A/en not_active Expired
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