BRPI0922457A2 - polymorphic form of 1- (4- {1 - [(e) -4-cyclohexyl-3-trifluoromethyl-benzyloxy-imino] -ethyl) -2-ethyl-benzyl) -azetidine-3-carboxylic acid " - Google Patents
polymorphic form of 1- (4- {1 - [(e) -4-cyclohexyl-3-trifluoromethyl-benzyloxy-imino] -ethyl) -2-ethyl-benzyl) -azetidine-3-carboxylic acid "Info
- Publication number
- BRPI0922457A2 BRPI0922457A2 BRPI0922457A BRPI0922457A BRPI0922457A2 BR PI0922457 A2 BRPI0922457 A2 BR PI0922457A2 BR PI0922457 A BRPI0922457 A BR PI0922457A BR PI0922457 A BRPI0922457 A BR PI0922457A BR PI0922457 A2 BRPI0922457 A2 BR PI0922457A2
- Authority
- BR
- Brazil
- Prior art keywords
- ethyl
- azetidine
- benzyloxy
- imino
- trifluoromethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20305208P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/068346 WO2010071794A1 (en) | 2008-12-18 | 2009-12-17 | New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0922457A2 true BRPI0922457A2 (en) | 2015-12-15 |
Family
ID=41566356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0922457A BRPI0922457A2 (en) | 2008-12-18 | 2009-12-17 | polymorphic form of 1- (4- {1 - [(e) -4-cyclohexyl-3-trifluoromethyl-benzyloxy-imino] -ethyl) -2-ethyl-benzyl) -azetidine-3-carboxylic acid " |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8173634B2 (en) |
| EP (1) | EP2379498B1 (en) |
| JP (1) | JP2012512884A (en) |
| KR (1) | KR20110112352A (en) |
| CN (1) | CN102256942B (en) |
| AU (1) | AU2009327405A1 (en) |
| BR (1) | BRPI0922457A2 (en) |
| CA (1) | CA2746764A1 (en) |
| ES (1) | ES2531831T3 (en) |
| MX (1) | MX2011006610A (en) |
| RU (1) | RU2011129230A (en) |
| WO (1) | WO2010071794A1 (en) |
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| US8352400B2 (en) | 1991-12-23 | 2013-01-08 | Hoffberg Steven M | Adaptive pattern recognition based controller apparatus and method and human-factored interface therefore |
| US7904187B2 (en) | 1999-02-01 | 2011-03-08 | Hoffberg Steven M | Internet appliance system and method |
| DK2661261T3 (en) * | 2011-01-07 | 2019-10-21 | Novartis Ag | Immunosuppressive Formulations |
| WO2012095853A1 (en) | 2011-01-10 | 2012-07-19 | Novartis Pharma Ag | Modified release formulations comprising sip receptor modulators |
| WO2015155711A1 (en) | 2014-04-10 | 2015-10-15 | Novartis Ag | Immunosuppressant formulation |
| WO2016135644A1 (en) | 2015-02-26 | 2016-09-01 | Novartis Ag | Treatment of autoimmune disease in a patient receiving additionally a beta-blocker |
| EP3400211A1 (en) | 2016-01-04 | 2018-11-14 | Auspex Pharmaceuticals, Inc. | Azetidine modulators of the sphingosine 1-phosphate receptor |
| US11958805B2 (en) | 2017-03-09 | 2024-04-16 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| US11629124B2 (en) * | 2017-03-09 | 2023-04-18 | Novartis Ag | Solid forms comprising an oxime ether compound, compositions and methods of use thereof |
| BR112020006223A2 (en) | 2017-09-27 | 2020-12-01 | Dr. Reddy's Laboratories Limited | process for the preparation of siponimod, its salts and solid forms thereof |
| CA3074416A1 (en) | 2017-09-29 | 2019-04-04 | Novartis Ag | Dosing regimen of siponimod |
| US20200316021A1 (en) | 2017-09-29 | 2020-10-08 | Novartis Ag | Dosing Regimen of Siponimod |
| EP3743405B1 (en) | 2018-01-22 | 2023-11-15 | Teva Pharmaceuticals International GmbH | Crystalline siponimod fumaric acid and polymorphs thereof |
| CN110776450B (en) * | 2018-07-27 | 2022-09-27 | 广东东阳光药业有限公司 | Siponimod crystal form and preparation method thereof |
| CN111484434A (en) * | 2019-01-29 | 2020-08-04 | 东莞市东阳光仿制药研发有限公司 | Siponimod crystal form and preparation method thereof |
| WO2020173346A1 (en) * | 2019-02-25 | 2020-09-03 | 广东东阳光药业有限公司 | Method for preparing siponimod |
| US20220144768A1 (en) * | 2019-02-27 | 2022-05-12 | Dr. Reddy's Laboratories Limited | Solid state forms of siponimod |
| WO2020201172A1 (en) * | 2019-03-29 | 2020-10-08 | Synthon B.V. | Process for making siponimod and intermediate thereof |
| EP3953326A1 (en) | 2019-04-11 | 2022-02-16 | Synthon B.V. | Solid forms of siponimod |
| KR20220093330A (en) | 2019-10-31 | 2022-07-05 | 이도르시아 파마슈티컬스 리미티드 | Combination of CXCR7 antagonist and S1P1 receptor modulator |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
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| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| TW225528B (en) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| BR9207175A (en) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composition containing vascular endothelial cell growth factor antagonist polypeptide monoclonal antibody amino acid sequence and method of treatment of tumor in mammal |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
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| WO1996030347A1 (en) | 1995-03-30 | 1996-10-03 | Pfizer Inc. | Quinazoline derivatives |
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| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| UA71587C2 (en) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Anthranilic acid amides and use thereof as medicaments |
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| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| JP4242911B2 (en) | 2004-08-26 | 2009-03-25 | ファイザー・インク | Enantiopure aminoheteroaryl compounds as protein kinase inhibitors |
| KR20070085465A (en) * | 2004-11-29 | 2007-08-27 | 노파르티스 아게 | Dosage regimen of an s1p receptor agonist |
| GT200600350A (en) | 2005-08-09 | 2007-03-28 | LIQUID FORMULATIONS | |
| GB0612721D0 (en) * | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
-
2009
- 2009-12-17 WO PCT/US2009/068346 patent/WO2010071794A1/en active Application Filing
- 2009-12-17 ES ES09793423.6T patent/ES2531831T3/en active Active
- 2009-12-17 MX MX2011006610A patent/MX2011006610A/en unknown
- 2009-12-17 EP EP09793423.6A patent/EP2379498B1/en active Active
- 2009-12-17 AU AU2009327405A patent/AU2009327405A1/en not_active Abandoned
- 2009-12-17 US US13/140,453 patent/US8173634B2/en active Active
- 2009-12-17 RU RU2011129230/04A patent/RU2011129230A/en not_active Application Discontinuation
- 2009-12-17 KR KR1020117016547A patent/KR20110112352A/en not_active Application Discontinuation
- 2009-12-17 CA CA2746764A patent/CA2746764A1/en not_active Abandoned
- 2009-12-17 BR BRPI0922457A patent/BRPI0922457A2/en not_active IP Right Cessation
- 2009-12-17 JP JP2011542412A patent/JP2012512884A/en active Pending
- 2009-12-17 CN CN2009801507913A patent/CN102256942B/en not_active Expired - Fee Related
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2012
- 2012-01-24 US US13/357,249 patent/US20120122836A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010071794A1 (en) | 2010-06-24 |
| EP2379498A1 (en) | 2011-10-26 |
| US8173634B2 (en) | 2012-05-08 |
| US20120122836A1 (en) | 2012-05-17 |
| CN102256942B (en) | 2013-07-24 |
| CA2746764A1 (en) | 2010-06-24 |
| CN102256942A (en) | 2011-11-23 |
| ES2531831T3 (en) | 2015-03-20 |
| KR20110112352A (en) | 2011-10-12 |
| EP2379498B1 (en) | 2015-01-21 |
| JP2012512884A (en) | 2012-06-07 |
| RU2011129230A (en) | 2013-01-27 |
| US20110251170A1 (en) | 2011-10-13 |
| AU2009327405A1 (en) | 2011-06-30 |
| MX2011006610A (en) | 2011-06-30 |
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