BRPI0914649A2 - Piprazolo-quinazolinas - Google Patents
Piprazolo-quinazolinasInfo
- Publication number
- BRPI0914649A2 BRPI0914649A2 BRPI0914649-0A BRPI0914649A BRPI0914649A2 BR PI0914649 A2 BRPI0914649 A2 BR PI0914649A2 BR PI0914649 A BRPI0914649 A BR PI0914649A BR PI0914649 A2 BRPI0914649 A2 BR PI0914649A2
- Authority
- BR
- Brazil
- Prior art keywords
- piprazole
- quinazolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08159114.1 | 2008-06-26 | ||
EP08159114 | 2008-06-26 | ||
PCT/EP2009/057512 WO2009156315A1 (en) | 2008-06-26 | 2009-06-17 | Pyrazolo-quinazolines |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0914649A2 true BRPI0914649A2 (pt) | 2015-07-07 |
BRPI0914649B1 BRPI0914649B1 (pt) | 2021-07-06 |
Family
ID=40887152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0914649-0A BRPI0914649B1 (pt) | 2008-06-26 | 2009-06-17 | Pirazolo-quinazolinas |
Country Status (21)
Country | Link |
---|---|
US (1) | US8846701B2 (pt) |
EP (1) | EP2303891B1 (pt) |
JP (1) | JP5542133B2 (pt) |
CN (1) | CN102076689B (pt) |
AR (2) | AR072374A1 (pt) |
AU (1) | AU2009264431B2 (pt) |
BR (1) | BRPI0914649B1 (pt) |
CA (1) | CA2729436C (pt) |
CL (1) | CL2010001538A1 (pt) |
CY (1) | CY1117595T1 (pt) |
DK (1) | DK2303891T3 (pt) |
EA (1) | EA020703B9 (pt) |
ES (1) | ES2572360T3 (pt) |
HK (1) | HK1154383A1 (pt) |
HR (1) | HRP20160243T1 (pt) |
HU (1) | HUE027527T2 (pt) |
MX (1) | MX2010013843A (pt) |
PL (1) | PL2303891T3 (pt) |
SI (1) | SI2303891T1 (pt) |
TW (1) | TWI464172B (pt) |
WO (1) | WO2009156315A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009071480A2 (en) * | 2007-12-04 | 2009-06-11 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
EP2417125B1 (en) * | 2009-03-27 | 2015-09-09 | Nerviano Medical Sciences S.r.l. | N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as mps1 kinase inhibitors |
ES2539972T3 (es) | 2010-07-30 | 2015-07-07 | Nerviano Medical Sciences S.R.L. | Isoxazolo-quinazolinas como moduladores de la actividad de proteina cinasa |
UA113280C2 (xx) | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ | |
CA2821837A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | 2-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
CN103298816A (zh) | 2010-12-17 | 2013-09-11 | 内尔维阿诺医学科学有限公司 | 作为激酶抑制剂的取代的吡唑并-喹唑啉衍生物 |
JP6302673B2 (ja) * | 2011-01-21 | 2018-03-28 | バジリア ファルマスーチカ アーゲーBasilea Pharmaceutica AG | フラザノベンゾイミダゾールに対する薬物応答のバイオマーカーとしてのbubr1の使用 |
EP2668188B1 (en) * | 2011-01-26 | 2016-05-18 | Nerviano Medical Sciences S.r.l. | Tricyclic derivatives, process for their preparation and their use as kinase inhibitors |
RU2591191C2 (ru) * | 2011-01-26 | 2016-07-10 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Трициклические пирроло производные, способ их получения и их применение в качестве ингибиторов киназы |
WO2012139930A1 (en) | 2011-04-11 | 2012-10-18 | Nerviano Medical Sciences S.R.L. | Pyrazolyl-pyrimidine derivatives as kinase inhibitors |
JP6399660B2 (ja) * | 2012-04-10 | 2018-10-03 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 癌治療用組成物および方法 |
WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
CN103130810B (zh) * | 2013-03-11 | 2015-02-25 | 河南师范大学 | 一种吡唑并[1,5-c]喹唑啉类化合物的合成方法 |
JP6518690B2 (ja) * | 2014-04-07 | 2019-05-22 | ネザーランズ トランスレーショナル リサーチ センター ビー.ブイ. | (5,6−ジヒドロ)ピリミド[4,5−e]インドリジン |
CN107567503B (zh) | 2015-04-17 | 2022-03-22 | 荷兰转化研究中心有限责任公司 | 用于ttk抑制剂化疗的预后生物标记 |
UY37778A (es) * | 2017-06-29 | 2019-01-31 | Servier Lab | NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN |
WO2019002542A1 (en) | 2017-06-30 | 2019-01-03 | Les Laboratoires Servier | COMBINATION OF AN INHIBITOR OF MPS1 AND A TAXANE COMPOUND, USES THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME |
JP7178401B2 (ja) * | 2017-07-11 | 2022-11-25 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | コリンキナーゼ阻害剤としてのピラゾロキナゾリン誘導体 |
WO2019029663A1 (zh) * | 2017-08-11 | 2019-02-14 | 晟科药业(江苏)有限公司 | 1h-吡唑并[4,3-h]喹唑啉类化合物作为蛋白激酶抑制剂 |
CA3171979A1 (en) | 2020-03-27 | 2021-09-30 | Josep Bassaganya-Riera | Plxdc2 ligands |
US20230416271A1 (en) * | 2020-11-26 | 2023-12-28 | Chengdu Cynogen Bio-Pharmaceutical Technology Co., Ltd. | Heteroarylquinazoline compounds as protein kinase inhibitors |
CN114685520A (zh) * | 2020-12-25 | 2022-07-01 | 武汉誉祥医药科技有限公司 | 三并环化合物及其药物组合物和应用 |
CN116528871A (zh) * | 2020-12-31 | 2023-08-01 | 恒元生物医药科技(苏州)有限公司 | 一种吡唑并喹唑啉类化合物、其制备方法及应用 |
WO2023113478A1 (en) * | 2021-12-15 | 2023-06-22 | Sillajen, Inc. | Methods of treating neoplastic diseases |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式2−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
MXPA04008130A (es) * | 2002-02-19 | 2004-11-26 | Pharmacia Corp | Derivados triciclicos de pirazol para el tratamiento de la inflamacion. |
OA13170A (en) * | 2003-05-22 | 2006-12-13 | Pharmacia Italia Spa | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors. |
SG177911A1 (en) * | 2006-12-21 | 2012-02-28 | Nerviano Medical Sciences Srl | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors |
-
2009
- 2009-06-17 AU AU2009264431A patent/AU2009264431B2/en active Active
- 2009-06-17 ES ES09769164T patent/ES2572360T3/es active Active
- 2009-06-17 JP JP2011515314A patent/JP5542133B2/ja active Active
- 2009-06-17 BR BRPI0914649-0A patent/BRPI0914649B1/pt active IP Right Grant
- 2009-06-17 SI SI200931429A patent/SI2303891T1/sl unknown
- 2009-06-17 CA CA2729436A patent/CA2729436C/en active Active
- 2009-06-17 HU HUE09769164A patent/HUE027527T2/en unknown
- 2009-06-17 EA EA201170090A patent/EA020703B9/ru unknown
- 2009-06-17 CN CN200980123813.7A patent/CN102076689B/zh active Active
- 2009-06-17 DK DK09769164.6T patent/DK2303891T3/en active
- 2009-06-17 PL PL09769164T patent/PL2303891T3/pl unknown
- 2009-06-17 WO PCT/EP2009/057512 patent/WO2009156315A1/en active Application Filing
- 2009-06-17 EP EP09769164.6A patent/EP2303891B1/en active Active
- 2009-06-17 MX MX2010013843A patent/MX2010013843A/es active IP Right Grant
- 2009-06-17 US US13/001,331 patent/US8846701B2/en active Active
- 2009-06-25 TW TW098121326A patent/TWI464172B/zh active
- 2009-06-26 AR ARP090102378A patent/AR072374A1/es not_active Application Discontinuation
-
2010
- 2010-12-23 CL CL2010001538A patent/CL2010001538A1/es unknown
-
2011
- 2011-08-12 HK HK11108487.0A patent/HK1154383A1/xx unknown
-
2016
- 2016-03-08 HR HRP20160243TT patent/HRP20160243T1/hr unknown
- 2016-05-12 CY CY20161100403T patent/CY1117595T1/el unknown
-
2018
- 2018-10-31 AR ARP180103174A patent/AR113818A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN102076689A (zh) | 2011-05-25 |
JP2011525516A (ja) | 2011-09-22 |
HRP20160243T1 (hr) | 2016-04-08 |
ES2572360T3 (es) | 2016-05-31 |
AU2009264431B2 (en) | 2013-11-07 |
MX2010013843A (es) | 2011-01-21 |
EA020703B1 (ru) | 2015-01-30 |
JP5542133B2 (ja) | 2014-07-09 |
PL2303891T3 (pl) | 2016-08-31 |
HUE027527T2 (en) | 2016-10-28 |
HK1154383A1 (en) | 2012-04-20 |
AR113818A2 (es) | 2020-06-17 |
SI2303891T1 (sl) | 2016-06-30 |
US8846701B2 (en) | 2014-09-30 |
DK2303891T3 (en) | 2016-05-30 |
AR072374A1 (es) | 2010-08-25 |
WO2009156315A1 (en) | 2009-12-30 |
US20110105542A1 (en) | 2011-05-05 |
TWI464172B (zh) | 2014-12-11 |
BRPI0914649B1 (pt) | 2021-07-06 |
CL2010001538A1 (es) | 2012-02-03 |
EP2303891A1 (en) | 2011-04-06 |
AU2009264431A2 (en) | 2011-02-17 |
EA020703B9 (ru) | 2015-12-30 |
CA2729436C (en) | 2016-08-09 |
TW201004960A (en) | 2010-02-01 |
CN102076689B (zh) | 2014-10-15 |
EP2303891B1 (en) | 2016-02-17 |
AU2009264431A1 (en) | 2009-12-30 |
EA201170090A1 (ru) | 2011-08-30 |
CA2729436A1 (en) | 2009-12-30 |
CY1117595T1 (el) | 2017-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25C | Requirement related to requested transfer of rights |
Owner name: NERVIANO MEDICAL SCIENCE S.R.L. (IT) |
|
B25A | Requested transfer of rights approved |
Owner name: LES LABORATOIRES SERVIER (FR) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07B | Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette] | ||
B07B | Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B09X | Republication of the decision to grant [chapter 9.1.3 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/06/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |
|
B25A | Requested transfer of rights approved |
Owner name: NERVIANO MEDICAL SCIENCES S.R.L. (IT) |