BRPI0818978B8 - new non-selective somatostatin analogues - Google Patents

new non-selective somatostatin analogues

Info

Publication number
BRPI0818978B8
BRPI0818978B8 BRPI0818978A BRPI0818978A BRPI0818978B8 BR PI0818978 B8 BRPI0818978 B8 BR PI0818978B8 BR PI0818978 A BRPI0818978 A BR PI0818978A BR PI0818978 A BRPI0818978 A BR PI0818978A BR PI0818978 B8 BRPI0818978 B8 BR PI0818978B8
Authority
BR
Brazil
Prior art keywords
new non
somatostatin analogues
selective
selective somatostatin
analogues
Prior art date
Application number
BRPI0818978A
Other languages
Portuguese (pt)
Inventor
Vitali Andrea
Pinori Massimo
Mascagni Paolo
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20072266 external-priority patent/ITMI20072266A1/en
Priority claimed from EP07425778A external-priority patent/EP2067786A1/en
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of BRPI0818978A2 publication Critical patent/BRPI0818978A2/en
Publication of BRPI0818978B1 publication Critical patent/BRPI0818978B1/en
Publication of BRPI0818978B8 publication Critical patent/BRPI0818978B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

novos análogos não-seletivos da somatostatina. novos análogos não-seletivos da somatostatina. a presente invenção refere-se a uma nova classe de ciclopeptidios da fórmula (i) , relatados abaixo, que são análogos funcionais não-seletivos da somatostatina.new non-selective somatostatin analogues. new non-selective somatostatin analogues. The present invention relates to a new class of cyclopeptides of formula (I), reported below, which are non-selective functional analogues of somatostatin.

BRPI0818978A 2007-12-03 2008-11-24 new non-selective somatostatin analogues BRPI0818978B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20072266 ITMI20072266A1 (en) 2007-12-03 2007-12-03 NEW NON-SELECTIVE SOMATOSTATINE ANALOGUES
EP07425778A EP2067786A1 (en) 2007-12-07 2007-12-07 Novel non selective analogs of somatostatin
PCT/EP2008/066081 WO2009071460A2 (en) 2007-12-03 2008-11-24 New non-selective somatostatin analogues

Publications (3)

Publication Number Publication Date
BRPI0818978A2 BRPI0818978A2 (en) 2016-05-03
BRPI0818978B1 BRPI0818978B1 (en) 2019-09-10
BRPI0818978B8 true BRPI0818978B8 (en) 2021-05-25

Family

ID=40667736

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0818978A BRPI0818978B8 (en) 2007-12-03 2008-11-24 new non-selective somatostatin analogues

Country Status (15)

Country Link
US (1) US8937152B2 (en)
EP (1) EP2225271B1 (en)
JP (1) JP5331817B2 (en)
KR (1) KR101500528B1 (en)
CN (1) CN101883785B (en)
BR (1) BRPI0818978B8 (en)
CA (1) CA2702940C (en)
CY (1) CY1114490T1 (en)
DK (1) DK2225271T3 (en)
ES (1) ES2431573T3 (en)
HR (1) HRP20130948T1 (en)
PL (1) PL2225271T3 (en)
PT (1) PT2225271E (en)
SI (1) SI2225271T1 (en)
WO (1) WO2009071460A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
PL2225271T3 (en) * 2007-12-03 2013-12-31 Italfarmaco Spa New non-selective somatostatin analogues
JP2013535514A (en) 2010-08-13 2013-09-12 エイルロン セラピューティクス，インコーポレイテッド Peptidomimetic macrocycle
EP2752425A4 (en) * 2011-09-04 2015-04-22 Glytech Inc Glycosylated polypeptide and drug composition containing said polypeptide
TW201806968A (en) 2011-10-18 2018-03-01 艾利倫治療公司 Peptidomimetic macrocycles
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN104159595A (en) 2012-02-15 2014-11-19 爱勒让治疗公司 Peptidomimetic macrocycles
MX2015005244A (en) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof.
US20160129089A1 (en) * 2013-06-13 2016-05-12 Antisense Therapeutics Ltd Combination therapy
CN103467575B (en) * 2013-08-22 2016-03-02 深圳翰宇药业股份有限公司 A kind of preparation method of Pa Xirui peptide
CN103641894B (en) * 2013-12-06 2015-10-28 深圳翰宇药业股份有限公司 A kind of preparation method treating the polypeptide drugs of hypercortisolism
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN104447962B (en) * 2014-12-29 2018-07-17 成都圣诺生物科技股份有限公司 A method of synthesis parritide
BR112017019738A2 (en) 2015-03-20 2018-05-29 Aileron Therapeutics Inc peptidomimetic macrocycles and their uses
CN112867512A (en) * 2018-09-25 2021-05-28 意大利国际先进加速器应用有限公司 Combination therapy
GB201816637D0 (en) * 2018-10-12 2018-11-28 Heptares Therapeutics Ltd Selective somatostatin receptor agonists
IT202100032615A1 (en) 2021-12-24 2023-06-24 Italfarmaco Spa Use of a somatostatin agonist in the treatment of SSTR3-expressing tumors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
US6365380B2 (en) 2000-02-23 2002-04-02 Pcbu Services, Inc. Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
WO2003077878A1 (en) * 2002-03-12 2003-09-25 The Procter & Gamble Company Cosmetic composition comprising double coated pigment
GB0206415D0 (en) 2002-03-19 2002-05-01 Glaxo Group Ltd Deracemisation of amines
GB0300095D0 (en) * 2003-01-03 2003-02-05 Novartis Ag Organic compounds
AR044852A1 (en) * 2003-06-24 2005-10-05 Novartis Ag A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
WO2005013958A1 (en) * 2003-08-07 2005-02-17 Novartis Ag Histone deacetylase inhibitors as immunosuppressants
GB0318682D0 (en) * 2003-08-08 2003-09-10 Novartis Ag Organic compounds
EP1522311A1 (en) * 2003-10-10 2005-04-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of somatostatin or analogs thereof for the preparation of a medicament for the regulation of ovarian follicles reserve by non menopausaled women
CA2546448A1 (en) * 2003-11-25 2005-06-16 Novartis Ag Biomarkers for the efficacy of somatostatin analogue treatment
ITFI20040057A1 (en) * 2004-03-10 2004-06-10 Mauro Giuntini ANALOGS OF THE SOMATOSTATINA
GB0428151D0 (en) 2004-12-22 2005-01-26 Novartis Ag Organic compounds
US7824663B2 (en) * 2005-03-10 2010-11-02 Kokyu Alcohol Kogyo Co., Ltd. Lip gloss composition
EP1787658B1 (en) * 2005-11-10 2012-03-14 CHEMI S.p.A. Sustained release formulations of somatostatin analogue inhibitors of growth hormone
PL2225271T3 (en) * 2007-12-03 2013-12-31 Italfarmaco Spa New non-selective somatostatin analogues

Also Published As

Publication number Publication date
JP2011505345A (en) 2011-02-24
KR101500528B1 (en) 2015-03-09
PL2225271T3 (en) 2013-12-31
CA2702940C (en) 2016-09-13
PT2225271E (en) 2013-09-27
BRPI0818978B1 (en) 2019-09-10
CA2702940A1 (en) 2009-06-11
CN101883785A (en) 2010-11-10
DK2225271T3 (en) 2013-10-07
JP5331817B2 (en) 2013-10-30
HRP20130948T1 (en) 2013-11-08
US20100323964A1 (en) 2010-12-23
EP2225271B1 (en) 2013-07-31
EP2225271A2 (en) 2010-09-08
US8937152B2 (en) 2015-01-20
BRPI0818978A2 (en) 2016-05-03
SI2225271T1 (en) 2013-10-30
ES2431573T3 (en) 2013-11-27
CY1114490T1 (en) 2016-10-05
KR20100103464A (en) 2010-09-27
WO2009071460A2 (en) 2009-06-11
CN101883785B (en) 2014-01-15
WO2009071460A3 (en) 2009-12-17

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

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B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/11/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF