BRPI0512104A8 - preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and their derivatives - Google Patents

preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and their derivatives

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Publication number
BRPI0512104A8
BRPI0512104A8 BRPI0512104A BRPI0512104A BRPI0512104A8 BR PI0512104 A8 BRPI0512104 A8 BR PI0512104A8 BR PI0512104 A BRPI0512104 A BR PI0512104A BR PI0512104 A BRPI0512104 A BR PI0512104A BR PI0512104 A8 BRPI0512104 A8 BR PI0512104A8
Authority
BR
Brazil
Prior art keywords
deoxy
fluoro
derivatives
alkyl
preparation
Prior art date
Application number
BRPI0512104A
Other languages
Portuguese (pt)
Inventor
Chun Byoung-Kwon
Du Jinfa
Shi Junxing
Wang Peiyuan
Stec Wojciech
Original Assignee
Gilead Pharmasset Llc
Pharmasset Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Pharmasset Llc, Pharmasset Inc filed Critical Gilead Pharmasset Llc
Priority claimed from PCT/US2005/025916 external-priority patent/WO2006012440A2/en
Publication of BRPI0512104A publication Critical patent/BRPI0512104A/en
Publication of BRPI0512104A8 publication Critical patent/BRPI0512104A8/en

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Abstract

preparação de 2-desóxi-2-flúor-d-ribofuranosil pirimidinas substituídas com alquila e purinas e seus derivados a presente invenção provê (i) um processo para preparação de um derivado de 2-desóxi-2-flúor-2-metil-d-ribonolactona, (ii) conversão da lactona nos nucleosídeos com atividade anti-hcv potente e seus análogos e (iii) método para preparar os nucleosídeos anti-hcv contendo os nucleosídeos 2-desóxi-2-flúor-2-c-metil--ß-d-ribofuranosila a partir de um nucleosídeo pré-formado, preferivelmente ocorrendo naturalmente.Preparation of Alkyl-Purified Substituted 2-Deoxy-2-Fluoro-d-Ribofuranosyl Pyrimidines and derivatives thereof The present invention provides (i) a process for preparing a 2-Deoxy-2-fluoro-2-methyl-d derivative (ii) conversion of lactone to potent anti-hcv activity nucleosides and their analogues and (iii) method for preparing anti-hcv nucleosides containing 2-deoxy-2-fluoro-2-c-methyl nucleosides-- ß-d-ribofuranosyl from a preformed nucleoside, preferably occurring naturally.

BRPI0512104A 2004-07-21 2005-07-21 preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and their derivatives BRPI0512104A8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58986604P 2004-07-21 2004-07-21
US60832004P 2004-09-09 2004-09-09
PCT/US2005/025916 WO2006012440A2 (en) 2004-07-21 2005-07-21 Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives

Publications (2)

Publication Number Publication Date
BRPI0512104A BRPI0512104A (en) 2008-03-11
BRPI0512104A8 true BRPI0512104A8 (en) 2018-04-24

Family

ID=39153774

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512104A BRPI0512104A8 (en) 2004-07-21 2005-07-21 preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and their derivatives

Country Status (1)

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BR (1) BRPI0512104A8 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3521297B1 (en) 2003-05-30 2021-12-22 Gilead Pharmasset LLC Modified fluorinated nucleoside analogues

Also Published As

Publication number Publication date
BRPI0512104A (en) 2008-03-11

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: GILEAD PHARMASSET LLC (US)

B25G Requested change of headquarter approved

Owner name: GILEAD PHARMASSET LLC (US)

B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07D Technical examination (opinion) related to article 229 of industrial property law
B07E Notice of approval relating to section 229 industrial property law

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Technical examination (opinion): publication of technical examination (opinion)
B09B Decision: refusal
B09B Decision: refusal

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL