BRPI0409650A - methods for regulating hematocrit and human levels, artificial erythropoietin products, methods for preparing an erythropoietin product and for treating anemia in patients at risk of tissue damage, and, pharmaceutical composition - Google Patents

methods for regulating hematocrit and human levels, artificial erythropoietin products, methods for preparing an erythropoietin product and for treating anemia in patients at risk of tissue damage, and, pharmaceutical composition

Info

Publication number
BRPI0409650A
BRPI0409650A BRPI0409650-9A BRPI0409650A BRPI0409650A BR PI0409650 A BRPI0409650 A BR PI0409650A BR PI0409650 A BRPI0409650 A BR PI0409650A BR PI0409650 A BRPI0409650 A BR PI0409650A
Authority
BR
Brazil
Prior art keywords
methods
erythropoietin
hematocrit
patients
artificial
Prior art date
Application number
BRPI0409650-9A
Other languages
Portuguese (pt)
Inventor
Anthony Cerami
John Smart
Michael Brines
Carla Cerami
Original Assignee
Warren Pharmaceuticals Inc
Kenneth S Warren Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/028073 external-priority patent/WO2004022577A2/en
Application filed by Warren Pharmaceuticals Inc, Kenneth S Warren Inst Inc filed Critical Warren Pharmaceuticals Inc
Publication of BRPI0409650A publication Critical patent/BRPI0409650A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"MéTODOS PARA REGULAR O NìVEL HEMATóCRITO EM HUMANOS, PRODUTO DE ERITROPOIETINA ARTIFICIAL, MéTODOS PARA PREPARAR UM PRODUTO DE ERITROPOIETINA E PARA TRATAR ANEMIA EM PACIENTES EM RISCO DE DANO NO TECIDO, E, COMPOSIçãO FARMACêUTICA". Métodos de incrementar o hematócrito de um indivíduo enquanto se conserva as atividades protetoras de tecidos da eritropoietina endógena por meio da administração de um composto farmacêutico contendo eritropoietina de ação prolongada quimicamente modificada. Divulga-se também as novas eritropoietinas de ação prolongada quimicamente modificadas, métodos de produzir as eritropoietinas de ação prolongada quimicamente modificadas, e composições compreendendo as eritropoietinas de ação prolongada quimicamente modificadas."METHODS FOR REGULATING HEMATOCYTE LEVEL IN HUMANS, ARTIFICIAL ERYTHROPOIETIN PRODUCT, METHODS FOR PREPARING AN ERYTHROPOIETIN PRODUCT AND TREATING ANEMIA IN PATIENTS AT RISK OF TISSUE DAMAGE, AND, PHARMACEUTICAL COMPOSITION." Methods of enhancing an individual's hematocrit while preserving tissue protective activities of endogenous erythropoietin by administering a pharmaceutical compound containing chemically modified long-acting erythropoietin. Also disclosed are novel chemically modified long-acting erythropoietins, methods of producing chemically modified long-acting erythropoietins, and compositions comprising chemically modified long-acting erythropoietins.

BRPI0409650-9A 2003-09-09 2004-03-08 methods for regulating hematocrit and human levels, artificial erythropoietin products, methods for preparing an erythropoietin product and for treating anemia in patients at risk of tissue damage, and, pharmaceutical composition BRPI0409650A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/028073 WO2004022577A2 (en) 2002-09-09 2003-09-09 Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin

Publications (1)

Publication Number Publication Date
BRPI0409650A true BRPI0409650A (en) 2006-04-25

Family

ID=34311726

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409650-9A BRPI0409650A (en) 2003-09-09 2004-03-08 methods for regulating hematocrit and human levels, artificial erythropoietin products, methods for preparing an erythropoietin product and for treating anemia in patients at risk of tissue damage, and, pharmaceutical composition

Country Status (3)

Country Link
CN (1) CN1882355A (en)
BR (1) BRPI0409650A (en)
WO (1) WO2005025606A1 (en)

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Publication number Priority date Publication date Assignee Title
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WO2005025606A1 (en) 2005-03-24
CN1882355A (en) 2006-12-20

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