DE19956568A1
(en)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Method and medicament for inhibiting the expression of a given gene
|
US7419964B2
(en)
|
1999-09-16 |
2008-09-02 |
Cytogenix, Inc. |
Treatment of HSV-related pathologies using ssDNA
|
AU7855300A
(en)
*
|
1999-10-04 |
2001-05-10 |
Cytogenix, Inc. |
Altering gene expression with ssDNA produced in vivo
|
DE10100586C1
(en)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Inhibiting gene expression in cells, useful for e.g. treating tumors, by introducing double-stranded complementary oligoRNA having unpaired terminal bases
|
AU2001277194A1
(en)
*
|
2000-07-28 |
2002-02-13 |
Oligotrail, Llc. |
Transgenic identification markers
|
EP2322648A1
(en)
|
2000-09-26 |
2011-05-18 |
Duke University |
RNA aptamers and methods for identifying the same
|
US7423142B2
(en)
|
2001-01-09 |
2008-09-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
SG157961A1
(en)
|
2001-05-25 |
2010-01-29 |
Univ Duke |
Modulators of pharmacological agents
|
US7745418B2
(en)
|
2001-10-12 |
2010-06-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting viral replication
|
AU2002363997A1
(en)
*
|
2001-12-14 |
2003-06-30 |
Yale University |
Intracellular generation of single-stranded dna
|
WO2003093424A2
(en)
*
|
2002-05-01 |
2003-11-13 |
Cytogenix, Inc. |
In vivo ssdna expression vectors for altering gene expression
|
US20050020526A1
(en)
*
|
2003-06-03 |
2005-01-27 |
Cytogenix, Inc. |
Oligodeoxynucleotide intervention for prevention and treatment of sepsis
|
AU2005222902B2
(en)
|
2004-03-12 |
2010-06-10 |
Alnylam Pharmaceuticals, Inc. |
iRNA agents targeting VEGF
|
ES2494940T3
(en)
|
2004-04-22 |
2014-09-16 |
Regado Biosciences, Inc. |
Enhanced coagulation factor modulators
|
JP2008514204A
(en)
*
|
2004-09-28 |
2008-05-08 |
サイトジェニックス, インコーポレイテッド |
Single-stranded antibacterial oligonucleotide and use thereof
|
US20100069461A1
(en)
|
2005-11-09 |
2010-03-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor v leiden mutant gene
|
US8658608B2
(en)
|
2005-11-23 |
2014-02-25 |
Yale University |
Modified triple-helix forming oligonucleotides for targeted mutagenesis
|
CA2647728C
(en)
|
2006-03-31 |
2014-12-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of eg5 gene
|
EP2013222B1
(en)
|
2006-04-28 |
2013-02-13 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibiting expression of a gene from the jc virus
|
EP2835429B1
(en)
|
2006-05-11 |
2017-12-13 |
Alnylam Pharmaceuticals Inc. |
Compositions and methods for inhibiting expression of the PCSK9 gene
|
EP2023937B1
(en)
|
2006-05-19 |
2011-10-12 |
Alnylam Pharmaceuticals Inc. |
Rnai modulation of aha and therapeutic uses thereof
|
US7888498B2
(en)
|
2006-05-22 |
2011-02-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of IKK-B gene
|
WO2008036638A2
(en)
|
2006-09-18 |
2008-03-27 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of scap and therapeutic uses thereof
|
CA2663581C
(en)
|
2006-09-21 |
2016-03-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the hamp gene
|
PE20090064A1
(en)
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
DOUBLE-CHAIN RIBONUCLEIC ACID TO INHIBIT THE EXPRESSION OF THE HUMAN E6AP GENE AND THE PHARMACEUTICAL COMPOSITION THAT INCLUDES IT
|
EA201000085A1
(en)
|
2007-07-05 |
2010-10-29 |
Новартис Аг |
dsPHK INTRODUCED FOR THE TREATMENT OF VIRAL INFECTION
|
US7871985B2
(en)
|
2007-12-10 |
2011-01-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor VII gene
|
EA201301171A1
(en)
|
2008-03-05 |
2014-10-30 |
Элнилэм Фармасьютикалз, Инк. |
COMPOSITIONS AND METHODS OF INHIBITING EXPRESSION OF EG5 AND VEGF GENES
|
EP2690175B1
(en)
|
2008-09-02 |
2016-12-28 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for combined inhibition of mutant EGFR gene and IL-6 expression
|
EP3584320A1
(en)
|
2008-09-25 |
2019-12-25 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
DK2344639T3
(en)
|
2008-10-20 |
2015-07-27 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TRANSTHYRETINE
|
AU2009324534B2
(en)
|
2008-12-10 |
2015-07-30 |
Alnylam Pharmaceuticals, Inc. |
GNAQ targeted dsRNA compositions and methods for inhibiting expression
|
US20120041051A1
(en)
|
2009-02-26 |
2012-02-16 |
Kevin Fitzgerald |
Compositions And Methods For Inhibiting Expression Of MIG-12 Gene
|
CN104922699B
(en)
|
2009-03-12 |
2020-07-24 |
阿尔尼拉姆医药品有限公司 |
Lipid formulated compositions and methods for inhibiting the expression of Eg5 and VEGF genes
|
MX2011013421A
(en)
|
2009-06-15 |
2012-03-16 |
Alnylam Pharmaceuticals Inc |
Lipid formulated dsrna targeting the pcsk9 gene.
|
WO2010147992A1
(en)
|
2009-06-15 |
2010-12-23 |
Alnylam Pharmaceuticals, Inc. |
Methods for increasing efficacy of lipid formulated sirna
|
ES2893199T3
(en)
|
2010-03-29 |
2022-02-08 |
Alnylam Pharmaceuticals Inc |
dsRNA therapy for transthyretin (TTR)-related ocular amyloidosis
|
AU2011261434B2
(en)
|
2010-06-02 |
2015-11-26 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
US9193973B2
(en)
|
2010-12-10 |
2015-11-24 |
Alynylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (EPO) production
|
EP2648763A4
(en)
|
2010-12-10 |
2014-05-14 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
BR112013025006B1
(en)
|
2011-03-29 |
2021-06-15 |
Alnylam Pharmaceuticals, Inc |
PHARMACEUTICAL COMPOSITION TO INHIBIT THE EXPRESSION OF A TMPRSS6 GENE, METHOD FOR INHIBITING TMPRSS6 EXPRESSION IN A CELL, AND USE OF DOUBLE TAPE RIBONU-CLEIC ACIDS
|
JP2014526882A
(en)
|
2011-06-21 |
2014-10-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Assays and methods for determining the activity of therapeutic agents in a subject
|
KR20230084331A
(en)
|
2011-06-21 |
2023-06-12 |
알닐람 파마슈티칼스 인코포레이티드 |
Compositions and methods for inhibition of expression of apolipoprotein c-iii(apoc3) genes
|
EP2723351B1
(en)
|
2011-06-21 |
2018-02-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of protein c (proc) genes
|
EP2723861A4
(en)
|
2011-06-21 |
2014-12-10 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting hepcidin antimicrobial peptide (hamp) or hamp-related gene expression
|
BR122019026068B8
(en)
|
2011-06-21 |
2022-10-18 |
Alnylam Pharmaceuticals |
DOUBLE-STRAND RIBONUCLEIC ACID (DSRNA) FOR INHIBITING ANGPTL3 EXPRESSION AND ITS USE, PHARMACEUTICAL COMPOSITION AND IN VITRO METHOD FOR INHIBITING ANGPTL3 EXPRESSION IN A CELL
|
US20140235693A1
(en)
|
2011-06-23 |
2014-08-21 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
EP2739735A2
(en)
|
2011-08-01 |
2014-06-11 |
Alnylam Pharmaceuticals, Inc. |
Method for improving the success rate of hematopoietic stem cell transplants
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
EP3336187A1
(en)
|
2012-12-05 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Pcsk9 irna compositions and methods of use thereof
|
WO2014130922A1
(en)
|
2013-02-25 |
2014-08-28 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
WO2014160418A2
(en)
|
2013-03-13 |
2014-10-02 |
GeneWeave Biosciences, Inc. |
Non-replicative transduction particles and transduction particle-based reporter systems
|
SG11201507400SA
(en)
|
2013-03-14 |
2015-10-29 |
Alnylam Pharmaceuticals Inc |
Complement component c5 irna compositions and methods of use thereof
|
EP2978446B1
(en)
|
2013-03-27 |
2020-03-04 |
The General Hospital Corporation |
Anti-cd33 antibody for use in treating alzheimer's disease
|
US10246708B2
(en)
|
2013-05-06 |
2019-04-02 |
Alnylam Pharmaceuticals, Inc. |
Dosages and methods for delivering lipid formulated nucleic acid molecules
|
LT2999785T
(en)
|
2013-05-22 |
2018-07-25 |
Alnylam Pharmaceuticals, Inc. |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202342750A
(en)
|
2013-05-22 |
2023-11-01 |
美商阿尼拉製藥公司 |
Tmprss6 irna compositions and methods of use thereof
|
US10077444B2
(en)
|
2013-10-02 |
2018-09-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the LECT2 gene
|
IL282747B2
(en)
|
2013-10-04 |
2023-10-01 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of the alas1 gene
|
IL294470A
(en)
|
2013-12-12 |
2022-09-01 |
Alnylam Pharmaceuticals Inc |
Complement component irna compositions and methods of use thereof
|
CA2938857A1
(en)
|
2014-02-11 |
2015-08-20 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
WO2015175510A1
(en)
|
2014-05-12 |
2015-11-19 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating a serpinc1-associated disorder
|
CN112301031A
(en)
|
2014-05-22 |
2021-02-02 |
阿尔尼拉姆医药品有限公司 |
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
|
JOP20200115A1
(en)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
Compositions And Methods For Inhibition Of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression
|
JOP20200092A1
(en)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
EP3221451A1
(en)
|
2014-11-17 |
2017-09-27 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
JP6975641B2
(en)
|
2015-04-13 |
2021-12-01 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Angiopoetin-like 3 (ANGPTL3) iRNA compositions and their use
|
EA201792444A1
(en)
|
2015-05-06 |
2018-06-29 |
Элнилэм Фармасьютикалз, Инк. |
COMPOSITIONS ON THE BASIS OF IRNA FOR FACTOR XII (HAGEMAN FACTOR) (F12), PLASMA KALLIKREIN B (FLETCH FACTOR) 1 (KLKB1) AND KININOGEN 1 (KNG1) AND FOSTER OF THE FLETCHER) (1)
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
PE20181131A1
(en)
|
2015-09-02 |
2018-07-17 |
Alnylam Pharmaceuticals Inc |
RNAi COMPOSITIONS FOR PROGRAMMED CELL DEATH 1 (PD-L1) LINK 1 (PD-L1) AND METHODS OF USE OF THEM
|
TW201718857A
(en)
|
2015-09-14 |
2017-06-01 |
艾爾妮蘭製藥公司 |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
SG11201804729RA
(en)
|
2015-12-07 |
2018-07-30 |
Genzyme Corp |
Methods and compositions for treating a serpinc1-associated disorder
|
WO2017100542A1
(en)
|
2015-12-10 |
2017-06-15 |
Alnylam Pharmaceuticals, Inc. |
Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
|
JP2019508037A
(en)
|
2016-02-16 |
2019-03-28 |
イェール ユニバーシティーYale Universit |
Compositions for enhancing targeted gene editing and methods of use thereof
|
MA45295A
(en)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
HIGH DENSITY LIPOPROTEIN BINDING PROTEIN (HDLBP / VIGILINE) RNA COMPOSITION AND METHODS FOR USING THEM
|
JP2019518028A
(en)
|
2016-06-10 |
2019-06-27 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Complement component C5i RNA composition and its use for treating paroxysmal nocturnal hemoglobinuria (PNH)
|
TWI788312B
(en)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
SG10201913552UA
(en)
|
2016-12-16 |
2020-03-30 |
Alnylam Pharmaceuticals Inc |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
BR112019021852A2
(en)
|
2017-04-18 |
2020-06-02 |
Alnylam Pharmaceuticals, Inc. |
RNAI AGENT AND A VACCINE AGAINST HBV, USE OR METHOD AND KIT FOR TREATMENT
|
AU2018301477A1
(en)
|
2017-07-13 |
2020-02-27 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (LDHA) iRNA compositions and methods of use thereof
|
CA3078971A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
WO2019099610A1
(en)
|
2017-11-16 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
EP3714054A1
(en)
|
2017-11-20 |
2020-09-30 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
MX2020006012A
(en)
|
2017-12-18 |
2020-09-14 |
Alnylam Pharmaceuticals Inc |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof.
|
US11008602B2
(en)
|
2017-12-20 |
2021-05-18 |
Roche Molecular Systems, Inc. |
Non-replicative transduction particles and transduction particle-based reporter systems
|
TW202016304A
(en)
|
2018-05-14 |
2020-05-01 |
美商阿尼拉製藥公司 |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
TW202020157A
(en)
|
2018-08-16 |
2020-06-01 |
美商艾爾妮蘭製藥公司 |
Compositions and methods for inhibiting expression of the lect2 gene
|
JP2022500003A
(en)
|
2018-09-18 |
2022-01-04 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Ketohexokinase (KHK) iRNA composition and its usage
|
CN113166760A
(en)
|
2018-11-23 |
2021-07-23 |
赛诺菲 |
Novel RNA compositions and methods for inhibiting ANGPTL8
|
WO2020136154A1
(en)
|
2018-12-27 |
2020-07-02 |
F. Hoffmann-La Roche Ag |
Non-replicative transduction particles and transduction particle-based reporter systems for detection of acinetobacter baumannii
|
US11572595B2
(en)
|
2018-12-31 |
2023-02-07 |
Roche Molecular Systems, Inc. |
Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems
|
EP4007811A2
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Carboxypeptidase b2 (cpb2) irna compositions and methods of use thereof
|
EP4007812A1
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Serpin family f member 2 (serpinf2) irna compositions and methods of use thereof
|
EP4013870A1
(en)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
|
CN115176011A
(en)
|
2019-08-27 |
2022-10-11 |
赛诺菲 |
Compositions and methods for inhibiting PCSK9
|
MX2022002689A
(en)
|
2019-09-03 |
2022-04-07 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of the lect2 gene.
|
EP4048807A1
(en)
|
2019-09-23 |
2022-08-31 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein b (apob) gene expression
|
CA3147643A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (hnf4.alpha.) gene expression
|
EP4038189A1
(en)
|
2019-10-04 |
2022-08-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
AU2020363372A1
(en)
|
2019-10-07 |
2022-05-19 |
University Of Virginia Patent Foundation |
Modulating lymphatic vessels in neurological disease
|
US20240141358A1
(en)
|
2019-10-18 |
2024-05-02 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
KR20220084399A
(en)
|
2019-10-22 |
2022-06-21 |
알닐람 파마슈티칼스 인코포레이티드 |
Complement component C3 iRNA compositions and methods of use thereof
|
MX2022004388A
(en)
|
2019-11-01 |
2022-05-06 |
Alnylam Pharmaceuticals Inc |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF.
|
EP4051796A1
(en)
|
2019-11-01 |
2022-09-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
EP4058577A1
(en)
|
2019-11-13 |
2022-09-21 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
|
US20230056569A1
(en)
|
2019-11-22 |
2023-02-23 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
IL293824A
(en)
|
2019-12-13 |
2022-08-01 |
Alnylam Pharmaceuticals Inc |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
WO2021126734A1
(en)
|
2019-12-16 |
2021-06-24 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
US20220356537A1
(en)
|
2019-12-31 |
2022-11-10 |
Roche Molecular Systems, Inc. |
Quantitative pcr screening of inducible prophage from bacterial isolates
|
EP4093426A1
(en)
|
2020-01-24 |
2022-11-30 |
University of Virginia Patent Foundation |
Modulating lymphatic vessels in neurological disease
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
JP2023514190A
(en)
|
2020-02-10 |
2023-04-05 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Compositions and methods for silencing VEGF-A expression
|
KR20220143106A
(en)
|
2020-02-18 |
2022-10-24 |
알닐람 파마슈티칼스 인코포레이티드 |
Apolipoprotein C3 (APOC3) iRNA composition and method of use thereof
|
MX2022011009A
(en)
|
2020-03-06 |
2022-10-07 |
Alnylam Pharmaceuticals Inc |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF.
|
CA3173528A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
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|
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(en)
|
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|
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|
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|
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(en)
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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|
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|
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(en)
|
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|
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|
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|
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(en)
|
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|
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|
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|
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|
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|
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(en)
|
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|
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|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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Alnylam Pharmaceuticals, Inc. |
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|
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(en)
|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|