BR9908895A - Pharmaceutical composition, compound, prodrug, compositions to antagonize a receptor, use of a compound, and, processes to produce a compound, to antagonize a receptor, to prevent or treat urination disorders in mammals and asthma disorders, rheumatoid arthritis, osteoarthritis, pain, cough, irritable bowel syndrome or vomiting in mammals - Google Patents

Pharmaceutical composition, compound, prodrug, compositions to antagonize a receptor, use of a compound, and, processes to produce a compound, to antagonize a receptor, to prevent or treat urination disorders in mammals and asthma disorders, rheumatoid arthritis, osteoarthritis, pain, cough, irritable bowel syndrome or vomiting in mammals

Info

Publication number
BR9908895A
BR9908895A BR9908895-9A BR9908895A BR9908895A BR 9908895 A BR9908895 A BR 9908895A BR 9908895 A BR9908895 A BR 9908895A BR 9908895 A BR9908895 A BR 9908895A
Authority
BR
Brazil
Prior art keywords
compound
ring
receptor
antagonize
mammals
Prior art date
Application number
BR9908895-9A
Other languages
Portuguese (pt)
Inventor
Hideaki Natsugari
Takayuki Doi
Yoshinori Ikeura
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of BR9908895A publication Critical patent/BR9908895A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA, COMPOSTO, PRó-MEDICAMENTO, COMPOSIçõES PARA ANTAGONIZAR UM RECEPTOR, USO DE UM COMPOSTO, E, PROCESSOS PARA PRODUZIR UM COMPOSTO, PARA ANTAGONIZAR UM RECEPTOR, PARA EVITAR OU TRATAR DISTúRBIOS DE MICçãO EM MAMìFEROS E DISTúRBIOS DE ASMA, ARTRITE REUMATóIDE, OSTEOARTRITE, DOR, TOSSE, SìNDROME DO INTESTINO IRRITáVEL OU VÈMITOS EM MAMìFEROS". Um composto representado pela fórmula (I): em que o anel M é um anel heterocíclico em que a fórmula (a): é uma de -N=C<, -CO-N< ou -CS-N<; R^ a^ e R^ b^ são ligados um ao outro para formar o anel A, ou são os mesmos ou diferentes e representam, independentemente, um átomo de hidrogênio ou um substituinte no anel M; o anel A e o anel B representam, independentemente, um anel homocíclico ou heterocíclico opcionalmente substituído, com a condição de que pelo menos um deles seja um anel heterocíclico opcionalmente substituído; o anel C é um anel homocíclico ou hetecocíclico opcionalmente substituído; o anel Z é um anel heterocíclico contendo nitrogênio opcionalmente substituído; e n é um número inteiro de 1 a 6, ou um sal destes tem uma atividade antagonística ao receptor de taquicinina in vitro, e é utilizável para evitar ou tratar a depressão, a ansiedade, a doença ou psicopatia maníaco depressiva."PHARMACEUTICAL COMPOSITION, COMPOUND, PRE-MEDICINAL PRODUCTS, COMPOSITIONS TO ANTAGONIZE A RECEPTOR, USE OF A COMPOUND, AND, PROCESSES TO PRODUCE A COMPOUND, TO ANTAGONIZE A RECEPTOR, TO AVOID OR TREAT DETERMINATIONS OF MICROMYTS IN MYMATERIC DETERMINES IN MYMETHYROMINISTS. , OSTEOARTHRITIS, PAIN, COUGH, IRRITABLE GUT SYNDROME OR VOMITING IN MAMMALIAN ". A compound represented by formula (I): in which ring M is a heterocyclic ring in which formula (a): is one of -N = C <, -CO-N <or -CS-N <; R ^ a ^ and R ^ b ^ are attached to each other to form ring A, or are the same or different and independently represent a hydrogen atom or a substituent on ring M; ring A and ring B independently represent an optionally substituted homocyclic or heterocyclic ring, with the proviso that at least one of them is an optionally substituted heterocyclic ring; ring C is an optionally substituted homocyclic or hetecocyclic ring; the Z ring is an optionally substituted nitrogen containing heterocyclic ring; and n is an integer from 1 to 6, or a salt of these has an antagonistic activity to the tachykinin receptor in vitro, and is usable to prevent or treat depression, anxiety, illness or manic depressive psychopathy.

BR9908895-9A 1998-03-19 1999-03-18 Pharmaceutical composition, compound, prodrug, compositions to antagonize a receptor, use of a compound, and, processes to produce a compound, to antagonize a receptor, to prevent or treat urination disorders in mammals and asthma disorders, rheumatoid arthritis, osteoarthritis, pain, cough, irritable bowel syndrome or vomiting in mammals BR9908895A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6999998 1998-03-19
PCT/JP1999/001358 WO1999047132A2 (en) 1998-03-19 1999-03-18 Heterocyclic compounds, their production and use as tachykinin receptor antagonists

Publications (1)

Publication Number Publication Date
BR9908895A true BR9908895A (en) 2000-12-05

Family

ID=13418890

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9908895-9A BR9908895A (en) 1998-03-19 1999-03-18 Pharmaceutical composition, compound, prodrug, compositions to antagonize a receptor, use of a compound, and, processes to produce a compound, to antagonize a receptor, to prevent or treat urination disorders in mammals and asthma disorders, rheumatoid arthritis, osteoarthritis, pain, cough, irritable bowel syndrome or vomiting in mammals

Country Status (12)

Country Link
EP (2) EP1061926A2 (en)
KR (1) KR20010041991A (en)
CN (1) CN1291099A (en)
AR (1) AR018772A1 (en)
AU (1) AU751114B2 (en)
BR (1) BR9908895A (en)
CA (1) CA2321155A1 (en)
HU (1) HUP0100934A3 (en)
ID (1) ID25818A (en)
IL (1) IL136950A0 (en)
NO (1) NO20004144L (en)
WO (1) WO1999047132A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI287003B (en) 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
AU2001292239A1 (en) * 2000-09-26 2002-04-08 Takeda Chemical Industries Ltd. Preventives/remedies for emotional disorders
EP1591120A4 (en) * 2003-01-28 2009-06-10 Takeda Chemical Industries Ltd Receptor agonists
JPWO2010016552A1 (en) 2008-08-07 2012-01-26 武田薬品工業株式会社 Drugs for irritable bowel syndrome
SG11201606080SA (en) 2014-02-03 2016-08-30 Vitae Pharmaceuticals Inc Dihydropyrrolopyridine inhibitors of ror-gamma
PT3207043T (en) 2014-10-14 2019-03-25 Vitae Pharmaceuticals Llc Dihydropyrrolopyridine inhibitors of ror-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
ES2856931T3 (en) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc ROR-gamma modulators
EP3377482B1 (en) 2015-11-20 2021-05-12 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI757266B (en) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 Modulators of ror-gamma
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of ror gamma
AR112461A1 (en) 2017-07-24 2019-10-30 Vitae Pharmaceuticals Inc PROCESSES FOR THE PRODUCTION OF SALTS AND CRYSTAL FORMS OF RORg INHIBITORS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100214905B1 (en) * 1991-05-31 1999-08-02 디. 제이. 우드, 스피겔 알렌 제이 Quinuclidine derivatives
ATE242243T1 (en) * 1995-03-24 2003-06-15 Takeda Chemical Industries Ltd CYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACHYKINE RECEPTOR ANTAGONISTS

Also Published As

Publication number Publication date
CA2321155A1 (en) 1999-09-23
WO1999047132A2 (en) 1999-09-23
AU751114B2 (en) 2002-08-08
AU2853299A (en) 1999-10-11
KR20010041991A (en) 2001-05-25
IL136950A0 (en) 2001-06-14
ID25818A (en) 2000-11-09
HUP0100934A2 (en) 2001-09-28
EP1184036A2 (en) 2002-03-06
EP1061926A2 (en) 2000-12-27
WO1999047132A3 (en) 1999-11-11
NO20004144L (en) 2000-10-10
HUP0100934A3 (en) 2002-09-30
CN1291099A (en) 2001-04-11
AR018772A1 (en) 2001-12-12
NO20004144D0 (en) 2000-08-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTA A 5O, 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.