BR9712392A - Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina - Google Patents
Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidinaInfo
- Publication number
- BR9712392A BR9712392A BR9712392-7A BR9712392A BR9712392A BR 9712392 A BR9712392 A BR 9712392A BR 9712392 A BR9712392 A BR 9712392A BR 9712392 A BR9712392 A BR 9712392A
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidine
- dimethyl
- methyl
- formula
- fluorophenylamino
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- LECZXZOBEZITCL-UHFFFAOYSA-N revaprazan Chemical compound C1CC2=CC=CC=C2C(C)N1C(C(=C(C)N=1)C)=NC=1NC1=CC=C(F)C=C1 LECZXZOBEZITCL-UHFFFAOYSA-N 0.000 title abstract 2
- QPILYVQSKNWRDD-UHFFFAOYSA-N 1-methyl-1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2C(C)NCCC2=C1 QPILYVQSKNWRDD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 150000003230 pyrimidines Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 4-fluorophenylamino Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSOS PARA PREPARAR 5,6-DIMETIL-2-(4-FLUOROFENIL-AMINO) - 4 - (1 - METIL - 1, 2, 3, 4 - TETRAIDROISQUINOLIN - 2 -IL) PIRIMIDINA, 4 - HALOGENO - 2 - (4 - FLUOROFENILAMINO) - 5, 6 -DIMETIL-PIRIMIDINA E 1-IMETIL-1,2,3,4-TETRAIDROISOQUINOLINA, E, DERIVADO DE PIRIMIDINA". A presente invenção refere-se primeiro a um processo para preparação de 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil-1,2,3,4-tetraidroisoquinoli n-2-il) pirimidina, representada pela fórmula (I): e seus sais de adição de ácido, segundo a um processo para preparação de um intermediário para preparar o composto (I) e, terceiro, a um novo composto intermediário. Mais especificamente, a presente invenção refere-se, primeiro a um processo para a preparação de 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil-1,2,3,4-tetraidroisquinolim- 5-il)pirimidina, representada pela fórmula (I), e seus sais de adição ácidos, pela reação de um derivado de pirimidina, representado pela fórmula (II-A), em que Hal representa um halogênio, com 1-metil-1,2,3,4-tetraisoquinolina representada pela fórmula (III), segundo, a um processo para preparação do derivado de pirimidina de fórmula II-A) e do composto de fórmula (III)e terceiro, a um novo composto intermediário, incluindo o derivado de fórmula(II-A).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960049381A KR100193080B1 (ko) | 1996-10-29 | 1996-10-29 | (r)-피리미딘 유도체의 제조방법 |
| KR1019960049382A KR100209587B1 (ko) | 1996-10-29 | 1996-10-29 | 피리미딘 유도체의 제조방법 |
| KR1019960049380A KR0185292B1 (ko) | 1996-10-29 | 1996-10-29 | (s)-피리미딘 유도체의 제조방법 |
| PCT/KR1997/000204 WO1998018784A1 (en) | 1996-10-29 | 1997-10-27 | Process for preparation of pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9712392A true BR9712392A (pt) | 2000-01-25 |
Family
ID=27349413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9712392-7A BR9712392A (pt) | 1996-10-29 | 1997-10-27 | Processos para preparar 5,6-dimetil-2-(4-fluorofenil-amino) -4- (1-metil-1,2,3,4 - tetraidroisoquinolin - 2 -il) pirimidina, 4 - halogeno - 2 - (4 - fluorofenilamino) -5,6 -dimetil-pirimidina e 1-metil-1,2,3,4-tetraidroisoquinolina, e, derivado de pirimidina |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR009133A1 (pt) |
| BR (1) | BR9712392A (pt) |
| HU (1) | HU226752B1 (pt) |
| TR (1) | TR199900943T2 (pt) |
| WO (1) | WO1998018784A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100272471B1 (ko) * | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| GB0110338D0 (en) * | 2001-04-27 | 2001-06-20 | Sb Pharmco Inc | Novel processes |
| CA2493618A1 (en) | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| US7776873B2 (en) | 2005-12-01 | 2010-08-17 | Yuhan Corporation | Method for treating damage to gastric mucosa |
| KR101784001B1 (ko) | 2006-04-04 | 2017-10-23 | 케이지 액퀴지션 엘엘씨 | 항혈소판제와 산 억제제를 포함하는 경구 투여용 약학 조성물 |
| CN102993173B (zh) * | 2012-12-28 | 2014-09-03 | 山东大学 | 洛氟普啶的制备方法 |
| CN105601611A (zh) | 2014-11-19 | 2016-05-25 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶多晶型物及其制备方法 |
| CN105669642B (zh) | 2014-11-19 | 2020-06-09 | 江苏天士力帝益药业有限公司 | 一种盐酸洛氟普啶的制备方法 |
| CN107759562B (zh) * | 2016-08-21 | 2020-10-23 | 常州四药制药有限公司 | 一种盐酸洛氟普啶的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1182584A (en) * | 1966-03-31 | 1970-02-25 | Ici Ltd | Pyrimidine derivates and the use thereof as fungicides |
| EP0388838B1 (de) * | 1989-03-22 | 1996-01-10 | Ciba-Geigy Ag | Schädlingsbekämpfungsmittel |
| KR0144833B1 (ko) * | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
| AU688087B2 (en) * | 1994-08-13 | 1998-03-05 | Yuhan Corporation | Novel pyrimidine derivatives and processes for the preparation thereof |
-
1997
- 1997-10-27 WO PCT/KR1997/000204 patent/WO1998018784A1/en active Application Filing
- 1997-10-27 TR TR1999/00943T patent/TR199900943T2/xx unknown
- 1997-10-27 BR BR9712392-7A patent/BR9712392A/pt not_active IP Right Cessation
- 1997-10-27 HU HU9903520A patent/HU226752B1/hu not_active IP Right Cessation
- 1997-10-28 AR ARP970104978A patent/AR009133A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9903520A1 (hu) | 2000-05-28 |
| HU226752B1 (en) | 2009-09-28 |
| AR009133A1 (es) | 2000-03-08 |
| WO1998018784A1 (en) | 1998-05-07 |
| TR199900943T2 (xx) | 1999-12-21 |
| HUP9903520A3 (en) | 2002-01-28 |
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Legal Events
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 16A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2257 DE 08-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |