BR9509760A - Compound - Google Patents
CompoundInfo
- Publication number
- BR9509760A BR9509760A BR9509760A BR9509760A BR9509760A BR 9509760 A BR9509760 A BR 9509760A BR 9509760 A BR9509760 A BR 9509760A BR 9509760 A BR9509760 A BR 9509760A BR 9509760 A BR9509760 A BR 9509760A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34415494A | 1994-11-23 | 1994-11-23 | |
| US34455294A | 1994-11-23 | 1994-11-23 | |
| US08/401,201 US5681956A (en) | 1990-12-28 | 1995-03-09 | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| PCT/US1995/015262 WO1996016040A1 (en) | 1994-11-23 | 1995-11-22 | Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9509760A true BR9509760A (en) | 1998-06-30 |
Family
ID=27407598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9509760A BR9509760A (en) | 1994-11-23 | 1995-11-22 | Compound |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0793653A1 (en) |
| JP (1) | JP2941950B2 (en) |
| CN (1) | CN1088062C (en) |
| AU (1) | AU4368996A (en) |
| BR (1) | BR9509760A (en) |
| CA (1) | CA2205998C (en) |
| MX (1) | MX9703736A (en) |
| WO (1) | WO1996016040A1 (en) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2261752A1 (en) * | 1996-08-08 | 1998-02-19 | Schering Corporation | Preparation of aminomethyl-phenylimidazoles |
| US5905152A (en) * | 1996-08-08 | 1999-05-18 | Schering Corporation | Preparation of aminomethyl-phenylimidazoles |
| DE19637237A1 (en) | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazine derivatives |
| PT988301E (en) | 1997-06-12 | 2006-10-31 | Aventis Pharma Ltd | CICID ACIDS OF IMIDAZOLYL |
| TW450954B (en) * | 1998-05-14 | 2001-08-21 | Pharmacia & Amp Upjohn Company | Phenylsulfonamide-phenylethylamines useful as dopamine receptors |
| WO1999064401A2 (en) * | 1998-06-12 | 1999-12-16 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Imidazolyl derivatives and their use as somatostatin receptor ligands |
| US6288230B1 (en) | 1998-09-29 | 2001-09-11 | Neurogen Corporation | 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
| WO2000018763A2 (en) * | 1998-09-29 | 2000-04-06 | Neurogen Corporation | 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands |
| US6284759B1 (en) | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
| ES2255311T3 (en) | 1998-10-08 | 2006-06-16 | Smithkline Beecham Plc | USEFUL TETRAHYDROBENZAZEPIN DERIVATIVES AS MODULATORS OF D3 DOPAMINE RECEPTORS (ANTI-PSYCHOTIC AGENTS). |
| US6284761B1 (en) | 1999-01-08 | 2001-09-04 | Neurogen Corporation | 1-phenyl-4-(1-[2-aryl]cyclopropyl)methylpiperazines: dopamine receptor ligands |
| WO2000040572A1 (en) * | 1999-01-08 | 2000-07-13 | Neurogen Corporation | 1-phenyl-4-(1-[2-aryl]cyclopropyl) methylpiperazines: dopamine receptor ligands |
| TWI274750B (en) * | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
| WO2002049993A2 (en) * | 2000-09-29 | 2002-06-27 | Neurogen Corporation | High affinity small molecule c5a receptor modulators |
| TWI283577B (en) * | 1999-10-11 | 2007-07-11 | Sod Conseils Rech Applic | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
| KR100822085B1 (en) * | 1999-10-11 | 2008-04-15 | 소시에떼 드 꽁세이으 드 르세르세 에 따블리까시옹 시앙띠피끄 (에스.세.에르.아.에스.) | 5-Membered Heterocycle Derivatives, Production Thereof and Use Thereof as Medicaments |
| FR2812546B1 (en) * | 2000-08-01 | 2008-11-21 | Sod Conseils Rech Applic | 5-CHAIN HETEROCYCLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| US6569861B2 (en) | 2000-07-06 | 2003-05-27 | Neurogen Corporation | Melanin concentrating hormone receptor ligands |
| NZ523774A (en) | 2000-08-01 | 2004-09-24 | Sod Conseils Rech Applic | Imidazolyl derivatives |
| MXPA03004652A (en) | 2000-12-21 | 2003-09-05 | Warner Lambert Co | Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists. |
| FR2818978B1 (en) * | 2000-12-28 | 2003-02-28 | Sod Conseils Rech Applic | MODULATORS OF SODIUM CHANNELS DERIVED FROM 2-PIPERIDYLIMIDAZOLES |
| TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| HUP0400266A2 (en) | 2001-06-21 | 2004-08-30 | Smithkline Beecham Corp. | Pharmaceutical compositions containing imidazo[1,2-a]pyridine derivatives, and their use for the prophylaxis and treatment of herpes viral infections |
| EP1432712B1 (en) | 2001-10-05 | 2006-05-17 | SmithKline Beecham Corporation | Imidazo-pyridine derivatives for use in the treatment of herpes viral infection |
| BRPI0412348A (en) * | 2003-07-30 | 2006-09-05 | Xenon Pharmaceuticals Inc | piperazine derivatives and their use as therapeutic agents |
| DE102004051277A1 (en) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclic carbonyl compounds |
| WO2006089076A2 (en) * | 2005-02-18 | 2006-08-24 | Neurogen Corporation | Thiazole amides, imidazole amides and related analogues |
| EP1939180A1 (en) | 2006-12-20 | 2008-07-02 | sanofi-aventis | Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase |
| EP1939181A1 (en) | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
| US8318746B2 (en) * | 2007-04-27 | 2012-11-27 | Takeda Pharmaceutical Company Limited | Nitrogen-containing five-membered heterocyclic compound |
| EA016687B8 (en) | 2007-08-22 | 2012-07-30 | Астразенека Аб | Cyclopropyl amide derivatives |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| KR20130004296A (en) | 2010-02-18 | 2013-01-09 | 아스트라제네카 아베 | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
| HUE036058T2 (en) | 2011-07-29 | 2018-06-28 | Karyopharm Therapeutics Inc | Hydrazide containing nuclear transport modulators and uses thereof |
| CA2842364A1 (en) * | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| WO2013148640A1 (en) | 2012-03-29 | 2013-10-03 | Merck Sharp & Dohme Corp. | Imidazolyl methyl piperidine t-type calcium channel antagonists |
| BR112014027860B8 (en) | 2012-05-09 | 2024-04-30 | Karyopharm Therapeutics Inc | Nuclear transport modulators and uses thereof |
| US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
| ES2724275T3 (en) | 2013-06-21 | 2019-09-09 | Karyopharm Therapeutics Inc | 1,2,4-triazoles as modulators of nuclear transport and their uses |
| WO2015154191A1 (en) * | 2014-04-10 | 2015-10-15 | Dalhousie University | Treatment of parkinson's disease through arfgap1 inhibition using substituted piperazine derivatives |
| EA201790384A1 (en) | 2014-08-15 | 2017-08-31 | Кариофарм Терапевтикс, Инк. | POLYMORPHES OF SILINEXOR |
| WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017117529A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
| JP7065951B2 (en) | 2017-09-22 | 2022-05-12 | ジュビラント エピパッド エルエルシー | Heterocyclic compound as a PAD inhibitor |
| CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
| CA3080677A1 (en) | 2017-11-06 | 2019-05-09 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
| MX2020005363A (en) | 2017-11-24 | 2020-10-01 | Jubilant Episcribe Llc | Heterocyclic compounds as prmt5 inhibitors. |
| MX2020009517A (en) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1319144C (en) * | 1986-11-14 | 1993-06-15 | Quirico Branca | Tetrahydronaphthalene derivatives |
| US5159083A (en) * | 1990-12-28 | 1992-10-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands |
| GB9306578D0 (en) * | 1993-03-30 | 1993-05-26 | Merck Sharp & Dohme | Therapeutic agents |
| CA2150345A1 (en) * | 1993-09-28 | 1995-04-06 | Makoto Komatsu | Quinoxaline derivative as antidiabetic agent |
-
1995
- 1995-11-22 JP JP8517074A patent/JP2941950B2/en not_active Expired - Lifetime
- 1995-11-22 CA CA002205998A patent/CA2205998C/en not_active Expired - Fee Related
- 1995-11-22 BR BR9509760A patent/BR9509760A/en not_active Application Discontinuation
- 1995-11-22 EP EP95942473A patent/EP0793653A1/en not_active Withdrawn
- 1995-11-22 WO PCT/US1995/015262 patent/WO1996016040A1/en not_active Application Discontinuation
- 1995-11-22 CN CN95197446A patent/CN1088062C/en not_active Expired - Fee Related
- 1995-11-22 AU AU43689/96A patent/AU4368996A/en not_active Abandoned
-
1997
- 1997-05-21 MX MX9703736A patent/MX9703736A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2205998C (en) | 2002-07-16 |
| MX9703736A (en) | 1998-07-31 |
| AU4368996A (en) | 1996-06-17 |
| JP2941950B2 (en) | 1999-08-30 |
| JPH10502670A (en) | 1998-03-10 |
| CN1088062C (en) | 2002-07-24 |
| WO1996016040A1 (en) | 1996-05-30 |
| EP0793653A1 (en) | 1997-09-10 |
| CN1177349A (en) | 1998-03-25 |
| CA2205998A1 (en) | 1996-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Technical examination (opinion): publication of technical examination (opinion) | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: C07D233/54; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D409/04; C07D409/14; A61K 31/415; A61P 25/16; A61P 25/18; A61P 25/24 |
|
| B09B | Decision: refusal |