BR112023022880A2 - MICRONIZED LIPIDS - Google Patents

MICRONIZED LIPIDS

Info

Publication number
BR112023022880A2
BR112023022880A2 BR112023022880A BR112023022880A BR112023022880A2 BR 112023022880 A2 BR112023022880 A2 BR 112023022880A2 BR 112023022880 A BR112023022880 A BR 112023022880A BR 112023022880 A BR112023022880 A BR 112023022880A BR 112023022880 A2 BR112023022880 A2 BR 112023022880A2
Authority
BR
Brazil
Prior art keywords
micronized
lipids
lipid
particles
eicosanyl
Prior art date
Application number
BR112023022880A
Other languages
Portuguese (pt)
Inventor
Thomas Gadek
Original Assignee
Mcal Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcal Therapeutics Inc filed Critical Mcal Therapeutics Inc
Publication of BR112023022880A2 publication Critical patent/BR112023022880A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

lipídeos micronizados. a presente invenção refere-se aos veículos de liberação de fármaco compreendendo partículas micronizadas que incluem um agente de lipídeo ativo, e, em particular, às partículas de lipídeo micronizadas que compreendem um lipídeo de éter tais como sn-1-o-eicosanil-sn-2-palmitoil-glicerol e seus isômeros.micronized lipids. The present invention relates to drug delivery vehicles comprising micronized particles that include an active lipid agent, and, in particular, to micronized lipid particles that comprise an ether lipid such as sn-1-o-eicosanyl-sn -2-palmitoyl-glycerol and its isomers.

BR112023022880A 2021-05-03 2021-05-03 MICRONIZED LIPIDS BR112023022880A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2021/030443 WO2022235252A1 (en) 2021-05-03 2021-05-03 Micronized lipids

Publications (1)

Publication Number Publication Date
BR112023022880A2 true BR112023022880A2 (en) 2024-01-23

Family

ID=83932912

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023022880A BR112023022880A2 (en) 2021-05-03 2021-05-03 MICRONIZED LIPIDS

Country Status (9)

Country Link
EP (1) EP4333794A1 (en)
JP (1) JP2024518440A (en)
KR (1) KR20240004849A (en)
CN (1) CN117580560A (en)
AU (1) AU2021444376A1 (en)
BR (1) BR112023022880A2 (en)
CA (1) CA3217006A1 (en)
IL (1) IL308124A (en)
WO (1) WO2022235252A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9003100D0 (en) * 1990-09-28 1990-09-28 Kabivitrum Ab LIPID FORMULATION SYSTEM
US8916539B2 (en) * 2000-01-10 2014-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of disease
US20060222716A1 (en) * 2005-04-01 2006-10-05 Joseph Schwarz Colloidal solid lipid vehicle for pharmaceutical use
CN105219789B (en) * 2014-06-27 2023-04-07 联邦科学技术研究组织 Extracted plant lipids comprising docosapentaenoic acid
CN109330992B (en) * 2018-12-07 2021-04-09 中国医科大学 Polydopamine modified nano-structure lipid carrier and application thereof in intradermal drug delivery

Also Published As

Publication number Publication date
EP4333794A1 (en) 2024-03-13
CA3217006A1 (en) 2022-11-10
IL308124A (en) 2023-12-01
WO2022235252A1 (en) 2022-11-10
CN117580560A (en) 2024-02-20
AU2021444376A1 (en) 2023-11-16
JP2024518440A (en) 2024-05-01
KR20240004849A (en) 2024-01-11

Similar Documents

Publication Publication Date Title
CO2021005774A2 (en) Ionizable amine lipids
BR112015023629A8 (en) ABIRATERONE ACETATE FORMULATION
CY1124380T1 (en) TRANSMUCOLOGICAL AND TRANSCUTANEOUS ADMINISTRATION SYSTEMS
PH12021551279A1 (en) Modified amine lipids
BR112017027876A2 (en) ? distribution system, method of preparation of the distribution system and composition?
BR112014024131A2 (en) ionizable cationic lipids
CL2019001447A1 (en) Preparation of solid cyclodextrin complexes for the supply of ophthalmic active pharmaceutical ingredients.
BR112019000528A2 (en) ve-mediated distribution of small molecule-binding protein conjugates
CO6650381A2 (en) Meso-sized particulate pesticide compositions with enhanced activity
BR112016027705A2 (en) biodegradable lipids for nucleic acid delivery
MX2016012893A (en) Supramolecular combinatorial therapeutics.
BR112016021023A8 (en) topical corticosteroid compositions
BR112013018920A2 (en) nanoparticle compositions, formulations thereof and their uses
MA35859B1 (en) Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation
BR112015017525A2 (en) modified peptide, salt of a modified peptide, medicament, and methods for treating or alleviating cardiovascular disease and for producing a modified peptide
BR112018001435A2 (en) methods for lymphatic delivery of active agents
BR112018013063A2 (en) bromodomain inhibitor and extra-terminal protein combination
BR112015020990A2 (en) substituted imidazopyridazine
EP4218722A3 (en) Biodegradable lipids for the delivery of active agents
BR112019011070A2 (en) fracture-driven bone regeneration through parathyroid hormone receptor stimulation
BR112014005434A2 (en) pharmaceutical compositions
CO2024000205A2 (en) RNA adsorbed on lipid nanoemulsion particles and their formulations
BR112023022880A2 (en) MICRONIZED LIPIDS
CR20120236A (en) PEST CONTROL LIQUID FORMULATION
WO2021188389A3 (en) Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells