US5552155A
(en)
*
|
1992-12-04 |
1996-09-03 |
The Liposome Company, Inc. |
Fusogenic lipsomes and methods for making and using same
|
US5776486A
(en)
*
|
1993-05-28 |
1998-07-07 |
Aphios Corporation |
Methods and apparatus for making liposomes containing hydrophobic drugs
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
EP0843555B1
(en)
|
1995-08-01 |
2003-08-27 |
Isis Pharmaceuticals, Inc. |
Liposomal oligonucleotide compositions
|
US6093816A
(en)
|
1996-06-27 |
2000-07-25 |
Isis Pharmaceuticals, Inc. |
Cationic lipids
|
US7262173B2
(en)
|
1997-03-21 |
2007-08-28 |
Georgetown University |
Chemosensitizing with liposomes containing oligonucleotides
|
JP4656675B2
(ja)
|
1997-05-14 |
2011-03-23 |
ユニバーシティー オブ ブリティッシュ コロンビア |
脂質小胞への荷電した治療剤の高率封入
|
WO1999005303A1
(en)
|
1997-07-24 |
1999-02-04 |
Inex Pharmaceuticals Corporation |
Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
|
US6410328B1
(en)
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
US6693086B1
(en)
|
1998-06-25 |
2004-02-17 |
National Jewish Medical And Research Center |
Systemic immune activation method using nucleic acid-lipid complexes
|
US20030022854A1
(en)
|
1998-06-25 |
2003-01-30 |
Dow Steven W. |
Vaccines using nucleic acid-lipid complexes
|
US6656498B1
(en)
|
1998-11-25 |
2003-12-02 |
Vanderbilt University |
Cationic liposomes for gene transfer
|
AU5905400A
(en)
|
1999-07-14 |
2001-02-05 |
Board Of Regents, The University Of Texas System |
Methods and compositions for delivery and retention of active agents to lymph nodes
|
US7094423B1
(en)
|
1999-07-15 |
2006-08-22 |
Inex Pharmaceuticals Corp. |
Methods for preparation of lipid-encapsulated therapeutic agents
|
EP2241308A3
(en)
|
2000-10-04 |
2010-11-17 |
Kyowa Hakko Kirin Co., Ltd. |
Method for coating fine particle with lipid membrane
|
US7713942B2
(en)
|
2001-04-04 |
2010-05-11 |
Nordic Vaccine Technology A/S |
Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
|
US20030077829A1
(en)
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
US7364750B2
(en)
|
2001-04-30 |
2008-04-29 |
The University Of British Columbia |
Autogene nucleic acids encoding a secretable RNA polymerase
|
EP1441763A2
(en)
|
2001-11-07 |
2004-08-04 |
Inex Pharmaceuticals Corp. |
Mucosal adjuvants comprising an oligonucleotide and a cationic lipid
|
ES2354607T3
(es)
|
2002-06-28 |
2011-03-16 |
Protiva Biotherapeutics Inc. |
Procedimiento y aparato para producir liposomas.
|
NZ544637A
(en)
|
2003-07-16 |
2010-04-30 |
Protiva Biotherapeutics Inc |
Lipid encapsulated interfering RNA
|
CN1882693B
(zh)
*
|
2003-09-15 |
2012-08-15 |
普洛体维生物治疗公司 |
聚乙二醇修饰的脂质化合物及其应用
|
JP2007526322A
(ja)
|
2004-03-02 |
2007-09-13 |
マサチューセッツ インスティテュート オブ テクノロジー |
ナノセル薬物送達系
|
EP1766035B1
(en)
|
2004-06-07 |
2011-12-07 |
Protiva Biotherapeutics Inc. |
Lipid encapsulated interfering rna
|
US7745651B2
(en)
|
2004-06-07 |
2010-06-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
US7807815B2
(en)
|
2004-07-02 |
2010-10-05 |
Protiva Biotherapeutics, Inc. |
Compositions comprising immunostimulatory siRNA molecules and DLinDMA or DLenDMA
|
WO2006007712A1
(en)
|
2004-07-19 |
2006-01-26 |
Protiva Biotherapeutics, Inc. |
Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
|
EP2199298A1
(en)
|
2004-11-17 |
2010-06-23 |
Protiva Biotherapeutics Inc. |
Sirna silencing of Apolipoprotein B
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
EP1874793A4
(en)
|
2005-04-15 |
2008-12-24 |
Univ Texas |
DISTRIBUTION OF SIRNA BY NEUTRAL LIPID COMPOSITIONS
|
US20080088046A1
(en)
|
2006-10-13 |
2008-04-17 |
Steffen Panzner |
Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
|
US20070087045A1
(en)
|
2005-10-14 |
2007-04-19 |
Industrial Technology Research Institute |
Lipid carrier and method of preparing the same
|
US7838658B2
(en)
|
2005-10-20 |
2010-11-23 |
Ian Maclachlan |
siRNA silencing of filovirus gene expression
|
CA2628300C
(en)
*
|
2005-11-02 |
2018-04-17 |
Protiva Biotherapeutics, Inc. |
Modified sirna molecules and uses thereof
|
US20070218122A1
(en)
|
2005-11-18 |
2007-09-20 |
Protiva Biotherapeutics, Inc. |
siRNA silencing of influenza virus gene expression
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
EP2056880A4
(en)
|
2006-08-16 |
2010-10-13 |
Protiva Biotherapeutics Inc |
NUCLEIC ACID MODULATION OF IMMUNE STIMULATION FACILITATED BY A RECIPTOR SIMILAR TO THE TOLL RECEIVER
|
EP2086507B1
(en)
*
|
2006-10-06 |
2018-11-07 |
BioNet Pharma GmbH |
A spinal nucleus pulposus implant
|
CN101903018B
(zh)
|
2007-10-17 |
2012-09-05 |
韩国科学技术院 |
用于递送核酸基因的ldl样阳离子纳米微粒、其制备方法以及使用其递送核酸基因的方法
|
US9006191B2
(en)
|
2007-12-27 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Silencing of polo-like kinase expression using interfering RNA
|
PT2279254T
(pt)
|
2008-04-15 |
2017-09-04 |
Protiva Biotherapeutics Inc |
Novas formulações lipídicas para entrega de ácido nucleico
|
US8268796B2
(en)
|
2008-06-27 |
2012-09-18 |
Children's Hospital & Research Center At Oakland |
Lipophilic nucleic acid delivery vehicle and methods of use thereof
|
US20110111044A1
(en)
|
2008-07-31 |
2011-05-12 |
Enzon Pharmaceuticals, Inc. |
Nanoparticle compositions for nucleic acids delivery system
|
PL2350043T3
(pl)
|
2008-10-09 |
2014-09-30 |
Tekmira Pharmaceuticals Corp |
Ulepszone aminolipidy i sposoby dostarczania kwasów nukleinowych
|
EA036772B1
(ru)
|
2008-10-20 |
2020-12-18 |
Элнилэм Фармасьютикалз, Инк. |
Композиции и способы для ингибирования экспрессии транстиретина
|
JP5832898B2
(ja)
|
2008-11-10 |
2015-12-16 |
テクミラ ファーマシューティカルズ コーポレイションTekmira Pharmaceuticals Corporation |
治療薬を送達するための新規な脂質及び組成物
|
TW201021853A
(en)
|
2008-11-17 |
2010-06-16 |
Enzon Pharmaceuticals Inc |
Releasable cationic lipids for nucleic acids delivery systems
|
CA2742689A1
(en)
|
2008-11-17 |
2010-05-20 |
Enzon Pharmaceuticals, Inc. |
Branched cationic lipids for nucleic acids delivery system
|
US10292932B2
(en)
|
2008-12-26 |
2019-05-21 |
Samyang Biopharmaceuticals Corporation |
Polymeric micelle particle comprising anionic drugs and method of preparing the same
|
WO2010108934A1
(en)
|
2009-03-25 |
2010-09-30 |
Novartis Ag |
Pharmaceutical composition containing a drug and sirna
|
NZ711583A
(en)
|
2009-05-05 |
2017-03-31 |
Arbutus Biopharma Corp |
Lipid compositions
|
CN102625696B
(zh)
|
2009-06-10 |
2015-06-03 |
阿尔尼拉姆医药品有限公司 |
改进的脂质制剂
|
JP5766188B2
(ja)
|
2009-07-01 |
2015-08-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
固形腫瘍に治療剤を送達するための脂質製剤
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
EP2810643A3
(en)
*
|
2009-08-14 |
2015-03-11 |
Alnylam Pharmaceuticals Inc. |
Lipid formulated compositions and mehods for inhibiting expression of a gene from the ebola virus
|
NZ599032A
(en)
|
2009-09-11 |
2014-09-26 |
Isis Pharmaceuticals Inc |
Modulation of huntingtin expression
|
CA2816925C
(en)
|
2009-11-04 |
2023-01-10 |
The University Of British Columbia |
Nucleic acid-containing lipid particles and related methods
|
DK3338765T3
(en)
|
2009-12-01 |
2019-03-04 |
Translate Bio Inc |
STEROID DERIVATIVE FOR THE SUPPLY OF MRNA IN HUMANGENETIC DISEASES
|
EP2525778B1
(en)
|
2010-01-19 |
2018-08-01 |
Polypid Ltd. |
Sustained-release nucleic acid matrix compositions
|
WO2011141704A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc |
Novel cyclic cationic lipids and methods of use
|
KR101198715B1
(ko)
|
2010-05-14 |
2012-11-13 |
한국생명공학연구원 |
핵산 및 친수성 음이온 화합물의 고효율 포획을 위한 비대칭 리포솜 및 이의 제조방법
|
US20100239521A1
(en)
|
2010-06-01 |
2010-09-23 |
Mohammad Reza Mozafari |
Method for the preparation of micro- and nano-sized carrier systems for the encapsulation of bioactive substances
|
AU2011261247B2
(en)
|
2010-06-03 |
2016-08-25 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
WO2012000104A1
(en)
|
2010-06-30 |
2012-01-05 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
BR112013004879A2
(pt)
|
2010-08-31 |
2018-04-24 |
Novartis Ag |
lipossomas pequenos para entrega de rna que codifica imunogénio
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
US9011903B2
(en)
|
2011-06-08 |
2015-04-21 |
Nitto Denko Corporation |
Cationic lipids for therapeutic agent delivery formulations
|
WO2012170889A1
(en)
|
2011-06-08 |
2012-12-13 |
Shire Human Genetic Therapies, Inc. |
Cleavable lipids
|
ME03491B
(me)
|
2011-06-08 |
2020-01-20 |
Translate Bio Inc |
Kompozicije lipidnih nanočestica i postupci za isporuku irnk
|
EP2729127B1
(en)
*
|
2011-07-04 |
2018-05-02 |
Statens Serum Institut |
Methods for producing liposomes
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
CN103974719A
(zh)
|
2011-08-31 |
2014-08-06 |
诺华股份有限公司 |
用于递送免疫原编码rna的聚乙二醇化脂质体
|
US8999950B2
(en)
|
2011-10-05 |
2015-04-07 |
Protiva Biotherapeutics Inc. |
Compositions and methods for silencing aldehyde dehydrogenase
|
RS58562B1
(sr)
|
2011-11-04 |
2019-05-31 |
Nitto Denko Corp |
Postupak za sterilnu proizvodnju čestica lipid-nukleinska kiselina
|
US9579338B2
(en)
|
2011-11-04 |
2017-02-28 |
Nitto Denko Corporation |
Method of producing lipid nanoparticles for drug delivery
|
HRP20220717T1
(hr)
|
2011-12-16 |
2022-07-22 |
Modernatx, Inc. |
Modificirani pripravci mrna
|
RS58077B1
(sr)
|
2012-02-24 |
2019-02-28 |
Arbutus Biopharma Corp |
Trialkil katjonski lipidi i postupci njihove primene
|
KR102084539B1
(ko)
|
2012-02-29 |
2020-03-04 |
상가모 테라퓨틱스, 인코포레이티드 |
헌팅턴병을 치료하기 위한 방법 및 조성물
|
DK2830595T3
(da)
|
2012-03-29 |
2019-12-02 |
Translate Bio Inc |
Ioniserbare kationiske lipider
|
AU2013243947A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
US20160289674A1
(en)
|
2012-04-02 |
2016-10-06 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of membrane proteins
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
US10501513B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
WO2013185069A1
(en)
|
2012-06-08 |
2013-12-12 |
Shire Human Genetic Therapies, Inc. |
Pulmonary delivery of mrna to non-lung target cells
|
DK3489220T3
(da)
|
2012-06-08 |
2021-09-06 |
Nitto Denko Corp |
Lipider til terapeutisk middel-leveringsformuleringer
|
LT2970456T
(lt)
|
2013-03-14 |
2021-08-10 |
Translate Bio, Inc. |
Būdai ir kompozicijos, skirti mrnr koduojamų antikūnų pristatymui
|
EA201591281A1
(ru)
|
2013-03-14 |
2016-02-29 |
Шир Хьюман Дженетик Терапис, Инк. |
Рибонуклеиновые кислоты с 4'-тиомодифицированными нуклеотидами и связанные с ними способы
|
WO2014144196A1
(en)
|
2013-03-15 |
2014-09-18 |
Shire Human Genetic Therapies, Inc. |
Synergistic enhancement of the delivery of nucleic acids via blended formulations
|
EP2971013B1
(en)
|
2013-03-15 |
2020-08-19 |
The University Of British Columbia |
Lipid nanoparticles for transfection and related methods
|
KR102109188B1
(ko)
|
2013-04-01 |
2020-05-11 |
삼성전자주식회사 |
양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도
|
EP3019595A4
(en)
*
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
CN110974981A
(zh)
|
2013-07-23 |
2020-04-10 |
野草莓树生物制药公司 |
用于递送信使rna的组合物和方法
|
US9453060B2
(en)
|
2013-08-09 |
2016-09-27 |
New York University |
Protein engineered systems for delivery of molecules
|
ES2707966T3
(es)
|
2013-10-22 |
2019-04-08 |
Translate Bio Inc |
Terapia de ARNm para la deficiencia en síntesis de argininosuccinato
|
JP6506749B2
(ja)
|
2013-10-22 |
2019-04-24 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
フェニルケトン尿症のためのmRNA療法
|
CN112618732A
(zh)
|
2013-10-22 |
2021-04-09 |
夏尔人类遗传性治疗公司 |
用于递送信使rna的脂质制剂
|
CN105658800A
(zh)
|
2013-10-22 |
2016-06-08 |
夏尔人类遗传性治疗公司 |
Mrna的cns递送及其用途
|
EP3096741B1
(en)
|
2014-01-21 |
2020-09-02 |
Anjarium Biosciences AG |
Process for the production of hybridosomes
|
DK3116997T3
(da)
|
2014-03-10 |
2019-08-19 |
Editas Medicine Inc |
Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
|
LT3122878T
(lt)
|
2014-03-24 |
2019-02-11 |
Translate Bio, Inc. |
Terapija mrnr, skirta akių ligų gydymui
|
US9833416B2
(en)
|
2014-04-04 |
2017-12-05 |
Ohio State Innovation Foundation |
Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
|
HRP20220070T1
(hr)
*
|
2014-04-23 |
2022-04-01 |
Modernatx, Inc. |
Cjepiva nukleinske kiseline
|
JP6557722B2
(ja)
|
2014-05-30 |
2019-08-07 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
核酸の送達のための生分解性脂質
|
CA2951707A1
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
CN106795142B
(zh)
|
2014-06-24 |
2022-11-04 |
川斯勒佰尔公司 |
用于递送核酸的立体化学富集组合物
|
EP3160448A4
(en)
|
2014-06-26 |
2018-11-14 |
Ramot at Tel-Aviv University Ltd. |
Liposomal formulations for delivery of nucleic acids
|
AU2015283954B2
(en)
|
2014-07-02 |
2020-11-12 |
Translate Bio, Inc. |
Encapsulation of messenger RNA
|
JP6767976B2
(ja)
|
2014-12-05 |
2020-10-14 |
トランスレイト バイオ, インコーポレイテッド |
関節疾患の治療のためのメッセンジャーrna治療法
|
EP3247328A1
(en)
*
|
2015-01-21 |
2017-11-29 |
PhaseRx, Inc. |
Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
|
US20180085474A1
(en)
|
2015-01-23 |
2018-03-29 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
EP3900702A1
(en)
*
|
2015-03-19 |
2021-10-27 |
Translate Bio, Inc. |
Mrna therapy for pompe disease
|
WO2016189532A1
(en)
|
2015-05-26 |
2016-12-01 |
Ramot At Tel-Aviv University Ltd. |
Targeted lipid particles for systemic delivery of nucleic acid molecules to leukocytes
|
US20180200186A1
(en)
|
2015-07-09 |
2018-07-19 |
Insmed Incorporated |
Compositions and methods for treating lung diseases and lung injury
|
ES2910425T3
(es)
|
2015-09-17 |
2022-05-12 |
Modernatx Inc |
Compuestos y composiciones para la administración intracelular de agentes terapéuticos
|
CN108430456B
(zh)
|
2015-10-22 |
2022-01-18 |
摩登纳特斯有限公司 |
癌症疫苗
|
JP6921833B2
(ja)
|
2015-10-22 |
2021-08-18 |
モデルナティーエックス, インコーポレイテッド |
ヒトサイトメガロウイルスワクチン
|
WO2017070624A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Tropical disease vaccines
|
CA3003267A1
(en)
|
2015-10-26 |
2017-05-04 |
Translate Bio Ma, Inc. |
Nanoparticle formulations for delivery of nucleic acid complexes
|
SI3386484T1
(sl)
|
2015-12-10 |
2022-06-30 |
Modernatx, Inc. |
Sestave in metode za dovajanje terapevtskih sredstev
|
JP6599560B2
(ja)
|
2015-12-18 |
2019-10-30 |
サムヤン バイオファーマシューティカルズ コーポレイション |
陰イオン性薬物を含有する高分子ミセルの製造方法
|
RS63051B1
(sr)
|
2015-12-22 |
2022-04-29 |
Modernatx Inc |
Jedinjenja i kompozicije za intracelularnu isporuku agenasa
|
CN107281103A
(zh)
|
2016-04-11 |
2017-10-24 |
百奥迈科生物技术有限公司 |
具有高含量阳性脂质化合物的脂质体制剂及其应用
|
EP3458589A4
(en)
|
2016-05-18 |
2020-01-01 |
Voyager Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
|
WO2017201332A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
WO2017218524A1
(en)
|
2016-06-13 |
2017-12-21 |
Rana Therapeutics, Inc. |
Messenger rna therapy for the treatment of ornithine transcarbamylase deficiency
|
AU2017286606A1
(en)
|
2016-06-14 |
2018-12-13 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
EP3519578B1
(en)
|
2016-10-03 |
2021-12-22 |
Precision Nanosystems Inc |
Compositions for transfecting resistant cell types
|
JP6980780B2
(ja)
|
2016-10-21 |
2021-12-15 |
モデルナティーエックス, インコーポレイテッド |
ヒトサイトメガロウイルスワクチン
|
EP3532094A1
(en)
|
2016-10-26 |
2019-09-04 |
CureVac AG |
Lipid nanoparticle mrna vaccines
|
US11583504B2
(en)
|
2016-11-08 |
2023-02-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
CA3039137A1
(en)
|
2016-11-08 |
2018-05-17 |
Ramot At Tel-Aviv University Ltd. |
Cationic lipids for nucleic acid delivery and preparation thereof
|
MX2019005470A
(es)
|
2016-11-10 |
2019-11-21 |
Translate Bio Inc |
Formulación de nanopartículas lipídicas basadas en ice mejorada para el suministro de arnm.
|
US20180153822A1
(en)
|
2016-11-10 |
2018-06-07 |
Translate Bio, Inc. |
Process of Preparing mRNA-Loaded Lipid Nanoparticles
|
AU2017374042B2
(en)
|
2016-12-09 |
2024-02-15 |
Acuitas Therapeutics, Inc. |
Delivery of target specific nucleases
|
US10383952B2
(en)
|
2016-12-21 |
2019-08-20 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
WO2018170336A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Lipid nanoparticle formulation
|
KR20190132405A
(ko)
|
2017-03-15 |
2019-11-27 |
모더나티엑스, 인크. |
치료제의 세포내 전달을 위한 화합물 및 조성물
|
EP3625342B1
(en)
*
|
2017-05-18 |
2022-08-24 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
US20210128474A1
(en)
|
2017-05-30 |
2021-05-06 |
Glaxosmithkline Biologicals S.A. |
Methods for manufacturing a liposome encapsulated rna
|
WO2018231990A2
(en)
|
2017-06-14 |
2018-12-20 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase
|
WO2018232120A1
(en)
|
2017-06-14 |
2018-12-20 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of agents
|
EP3638215A4
(en)
|
2017-06-15 |
2021-03-24 |
Modernatx, Inc. |
RNA FORMULATIONS
|
US10780183B2
(en)
|
2017-06-19 |
2020-09-22 |
Translate Bio, Inc. |
Messenger RNA therapy for the treatment of Friedreich's ataxia
|
MX2020000495A
(es)
|
2017-07-14 |
2020-08-20 |
Oncorus Inc |
Polinucleotidos encapsulados y metodos de uso.
|
US11633365B2
(en)
|
2017-08-04 |
2023-04-25 |
Kyowa Kirin Co., Ltd. |
Nucleic acid-containing lipid nanoparticle
|
JP7355731B2
(ja)
|
2017-08-16 |
2023-10-03 |
アクイタス セラピューティクス インコーポレイテッド |
脂質ナノ粒子製剤における使用のための脂質
|
US11542225B2
(en)
|
2017-08-17 |
2023-01-03 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
EP3668834A1
(en)
|
2017-08-17 |
2020-06-24 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
AU2018326799A1
(en)
|
2017-08-31 |
2020-02-27 |
Modernatx, Inc. |
Methods of making lipid nanoparticles
|
WO2019089828A1
(en)
|
2017-10-31 |
2019-05-09 |
Acuitas Therapeutics, Inc. |
Lamellar lipid nanoparticles
|
CN111565706A
(zh)
|
2017-11-09 |
2020-08-21 |
免疫疫苗技术公司 |
药物组合物、包括脂质囊泡颗粒尺寸设定的制备方法及其用途
|
AU2018379379A1
(en)
|
2017-12-06 |
2020-06-18 |
Newsouth Innovations Pty Limited |
Liposomal system for drug delivery
|
WO2019118621A1
(en)
|
2017-12-12 |
2019-06-20 |
The Johns Hopkins University |
Methods for making giant vesicles and their use
|
AU2018392716A1
(en)
|
2017-12-20 |
2020-06-18 |
Translate Bio, Inc. |
Improved composition and methods for treatment of ornithine transcarbamylase deficiency
|
US20210024928A1
(en)
|
2018-02-16 |
2021-01-28 |
Mina Therapeutics Limited |
C/ebp alpha sarna compositions and methods of use
|
WO2019169203A1
(en)
|
2018-02-28 |
2019-09-06 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs for survival of motor neuron (sma) inhibitors
|
WO2019191341A1
(en)
|
2018-03-27 |
2019-10-03 |
Factor Bioscience Inc. |
Nucleic acid-based therapeutics
|
US20230149310A1
(en)
|
2018-03-30 |
2023-05-18 |
Arcturus Therapeutics, Inc. |
Lipid particles for nucleic acid delivery
|
BR112020020933A2
(pt)
|
2018-04-17 |
2021-04-06 |
Curevac Ag |
Moléculas de rna de rsv inovadoras e composições para vacinação
|
JP7379776B2
(ja)
|
2018-04-29 |
2023-11-15 |
プレシジョン ナノシステムズ ユーエルシー |
耐性細胞型をトランスフェクトするための組成物
|
WO2019213308A1
(en)
|
2018-05-01 |
2019-11-07 |
Fred Hutchinson Cancer Research Center |
Nanoparticles for gene expression and uses thereof
|
US20210189397A1
(en)
|
2018-05-10 |
2021-06-24 |
Northwestern University |
Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology
|
US20210346306A1
(en)
|
2018-05-23 |
2021-11-11 |
Modernatx, Inc. |
Delivery of dna
|
JP7488193B2
(ja)
|
2018-05-24 |
2024-05-21 |
トランスレイト バイオ, インコーポレイテッド |
チオエステルカチオン性脂質
|
CA3106893A1
(en)
|
2018-07-21 |
2020-01-30 |
University Of Tennessee Research Foundation |
Neutral liposomes containing biologically active agents
|
KR20210056331A
(ko)
|
2018-07-23 |
2021-05-18 |
트랜슬레이트 바이오 인코포레이티드 |
전령 rna의 건조 분말 제형
|
WO2020028133A1
(en)
|
2018-07-30 |
2020-02-06 |
Trucode Gene Repair, Inc. |
Lipid nanoparticle formulations comprising nucleic acid mimics
|
WO2020051243A1
(en)
|
2018-09-04 |
2020-03-12 |
Ohio State Innovation Foundation |
Lipid nanoparticles and methods of using thereof
|
GB2600800B
(en)
*
|
2018-09-04 |
2023-08-16 |
Univ Texas |
Compositions and methods for organ specific delivery of nucleic acids
|
US20230145188A1
(en)
|
2018-09-14 |
2023-05-11 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
JP7410135B2
(ja)
|
2018-09-19 |
2024-01-09 |
モデルナティエックス インコーポレイテッド |
治療薬の細胞内送達のための化合物及び組成物
|
JP2022501367A
(ja)
|
2018-09-20 |
2022-01-06 |
モデルナティエックス インコーポレイテッドModernaTX, Inc. |
脂質ナノ粒子の調製及びその投与方法
|
DK3864163T3
(da)
|
2018-10-09 |
2024-05-06 |
Univ British Columbia |
Sammensætninger og systemer omfattende transfektionskompetente vesikler fri for organiske opløsningsmidler og rengøringsmidler og fremgangsmåder forbundet dermed
|
US20220016265A1
(en)
|
2018-11-09 |
2022-01-20 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
US20220001029A1
(en)
|
2018-11-09 |
2022-01-06 |
Arbutus Biopharma Corporation |
Lipid nanoparticle formulations
|
US20220071905A1
(en)
|
2018-11-09 |
2022-03-10 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
CA3118557A1
(en)
|
2018-11-09 |
2020-05-14 |
Arbutus Biopharma Corporation |
Negatively charged peg-lipid conjugates
|
CA3119051A1
(en)
|
2018-11-09 |
2020-05-14 |
Arbutus Biopharma Corporation |
Cationic lipids containing silicon
|
AU2019378763A1
(en)
|
2018-11-12 |
2021-06-03 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
EP3880212B1
(en)
|
2018-11-16 |
2024-01-17 |
Nitto Denko Corporation |
Rna interference delivery formulation and methods for malignant tumors
|
CA3120647A1
(en)
|
2018-11-21 |
2020-05-28 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr
|
CN113453699A
(zh)
|
2019-01-04 |
2021-09-28 |
昂克诺斯公司 |
包封的rna多核苷酸及使用方法
|
US20220023214A1
(en)
|
2019-01-24 |
2022-01-27 |
CannaClear Inc. |
Lecithin Vesicles for Oral Delivery
|
JP2022518479A
(ja)
|
2019-01-24 |
2022-03-15 |
ノースウェスタン ユニバーシティ |
脂質結合体化コア足場を使用する高密度リポタンパク質模倣ナノ粒子
|
CN113767172A
(zh)
|
2019-01-31 |
2021-12-07 |
新南创新私人有限公司 |
脂质体纳米颗粒
|
BR112021014845A2
(pt)
|
2019-01-31 |
2021-11-03 |
Modernatx Inc |
Métodos de preparação de nanopartículas lipídicas
|
KR20220018960A
(ko)
|
2019-03-19 |
2022-02-15 |
아크투루스 쎄라퓨틱스, 인크. |
지질-캡슐화된 rna 나노입자 제조 방법
|
JPWO2020189773A1
(pt)
|
2019-03-20 |
2020-09-24 |
|
|
AU2020260280B2
(en)
|
2019-04-15 |
2023-06-29 |
Precision NanoSystems ULC |
Nonviral modification of t cell gene expression
|
US20220177880A1
(en)
|
2019-05-03 |
2022-06-09 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
CA3139321A1
(en)
|
2019-05-07 |
2020-11-12 |
Modernatx, Inc. |
Polynucleotides for disrupting immune cell activity and methods of use thereof
|
MX2021013959A
(es)
|
2019-05-14 |
2022-04-01 |
Translate Bio Inc |
Proceso mejorado de preparación de nanopartículas lipídicas cargadas de arnm.
|
CN114286671A
(zh)
|
2019-06-14 |
2022-04-05 |
DNALite治疗学公司 |
用于生物递送媒介物的组合物和方法
|
WO2020254535A1
(en)
|
2019-06-18 |
2020-12-24 |
Curevac Ag |
Rotavirus mrna vaccine
|
WO2020252589A1
(en)
|
2019-06-20 |
2020-12-24 |
Precision Nanosystems Inc. |
Ionizable lipids for nucleic acid delivery
|
US20220378917A1
(en)
|
2019-06-29 |
2022-12-01 |
Precision NanoSystems ULC |
Ionizable lipids for nucleic acid delivery
|
JP2022542562A
(ja)
|
2019-07-23 |
2022-10-05 |
トランスレイト バイオ, インコーポレイテッド |
mRNA担持脂質ナノ粒子の安定性組成物および作製のプロセス
|
US20220273566A1
(en)
|
2019-07-29 |
2022-09-01 |
Georgia Tech Research Corporation |
Nanomaterials containing constrained lipids and uses thereof
|
WO2021022008A1
(en)
|
2019-07-30 |
2021-02-04 |
Verndari, Inc. |
Virus-like particle vaccines
|
US20220280639A1
(en)
|
2019-07-31 |
2022-09-08 |
Modernatx, Inc. |
Compositions and methods for delivery of rna interference agents to immune cells
|
US20220296517A1
(en)
|
2019-08-07 |
2022-09-22 |
Moderna TX, Inc. |
Compositions and methods for enhanced delivery of agents
|
CN114502204A
(zh)
|
2019-08-14 |
2022-05-13 |
库尔维科公司 |
具有降低的免疫刺激性质的rna组合和组合物
|
MX2022001720A
(es)
|
2019-08-14 |
2022-03-11 |
Acuitas Therapeutics Inc |
Nanoparticulas lipidicas mejoradas para el suministro de acidos nucleicos.
|
US20230172858A1
(en)
|
2019-08-30 |
2023-06-08 |
Glaxosmithkline Biologicals Sa |
Jet mixing lipid nanoparticle manufacturing process
|
EP4031191A4
(en)
|
2019-09-18 |
2023-10-25 |
The Regents of the University of California |
PROTEIN-PRODUCING NANOLIPOSOMES AND THEIR USES
|
CA3154618A1
(en)
|
2019-09-19 |
2021-03-25 |
Modernatx, Inc. |
Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
|
JP2022553375A
(ja)
|
2019-10-22 |
2022-12-22 |
ジェネバント サイエンシズ ゲーエムベーハー |
オルニチントランスカルバミラーゼ(otc)構築物およびそれを使用する方法
|
CA3154774A1
(en)
|
2019-11-22 |
2021-05-27 |
Generation Bio Co. |
Ionizable lipids and nanoparticle compositions thereof
|
WO2021108731A1
(en)
|
2019-11-25 |
2021-06-03 |
The Methodist Hospital |
Aposome compositions and methods of use
|
EP3838266A1
(en)
|
2019-12-20 |
2021-06-23 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Microfluidic production of biofunctionalized giant unilamellar vesicles for targeted intracellular cargo delivery
|
KR20220130712A
(ko)
|
2019-12-31 |
2022-09-27 |
프레드 허친슨 캔서 센터 |
치료 부위에서 면역계 반응을 자극하고 유지하기 위한 나노입자 시스템
|
EP3858332A1
(en)
|
2020-01-31 |
2021-08-04 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Bottom-up assembly of synthetic extracellular vesicles
|
EP4096644A1
(en)
|
2020-01-31 |
2022-12-07 |
Modernatx, Inc. |
Methods of preparing lipid nanoparticles
|
CN116113430A
(zh)
|
2020-02-04 |
2023-05-12 |
奎尔法克股份有限公司 |
冠状病毒疫苗
|
CN113186203B
(zh)
|
2020-02-13 |
2022-12-30 |
斯微(上海)生物科技股份有限公司 |
治疗或者预防冠状病毒病的疫苗试剂
|
WO2021173840A1
(en)
|
2020-02-25 |
2021-09-02 |
Translate Bio, Inc. |
Improved processes of preparing mrna-loaded lipid nanoparticles
|
CN113999184A
(zh)
|
2020-02-28 |
2022-02-01 |
深圳深信生物科技有限公司 |
一种胺基脂质化合物、其制备方法和应用
|
MX2022011988A
(es)
|
2020-03-27 |
2023-01-04 |
Generation Bio Co |
Nuevos lipidos y composiciones de nanopartículas de estos.
|
US11559577B2
(en)
|
2020-03-31 |
2023-01-24 |
Engimata, Inc. |
Immunogenic composition forming a vaccine, and a method for its manufacture
|
CN113456591B
(zh)
|
2020-03-31 |
2022-06-14 |
武汉合生科技有限公司 |
糖基聚醚类化合物脂质体及其制备方法和药物
|
US20230285291A1
(en)
|
2020-04-07 |
2023-09-14 |
The Regents Of The University Of California |
Manufacturing of synthetic exosomes for cns and non-cns delivery of therapeutics
|
US20230147733A1
(en)
|
2020-04-10 |
2023-05-11 |
Northwestern University |
Oxidized tumor cell lysates encapsulated in liposomal spherical nucleic acids as potent cancer immunotherapeutics
|
JP2021185136A
(ja)
|
2020-04-22 |
2021-12-09 |
ビオエンテッヒ・アールエヌエイ・ファーマシューティカルズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
コロナウイルスワクチン
|
CA3176844A1
(en)
|
2020-05-01 |
2021-11-04 |
Carlos G. PEREZ-GARCIA |
Nucleic acids and methods of treatment for cystic fibrosis
|
US20230181619A1
(en)
|
2020-05-07 |
2023-06-15 |
Translate Bio, Inc. |
Improved compositions for cftr mrna therapy
|
WO2021226463A1
(en)
|
2020-05-07 |
2021-11-11 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
AU2021273502A1
(en)
|
2020-05-15 |
2023-02-02 |
Translate Bio, Inc. |
Lipid nanoparticle formulations for mRNA delivery
|
IL298282A
(en)
|
2020-05-18 |
2023-01-01 |
Max Biology Co Ltd |
Polymer-lipid compounds and methods of use
|
WO2021236479A2
(en)
|
2020-05-18 |
2021-11-25 |
Generation Bio Co. |
Novel lipids and nanoparticle compositions thereof
|
US20240042015A1
(en)
|
2020-05-19 |
2024-02-08 |
Orna Therapeutics, Inc. |
Circular rna compositions and methods
|
US20220049251A1
(en)
|
2020-05-20 |
2022-02-17 |
Nitto Denko Corporation |
dsRNA Directed to Coronavirus Proteins
|
JP2023530229A
(ja)
|
2020-05-29 |
2023-07-14 |
キュアバック エスイー |
核酸ベースの混合ワクチン
|
CN115666722A
(zh)
|
2020-05-29 |
2023-01-31 |
昂克诺斯公司 |
包封的rna复制子和使用方法
|
US20230029453A1
(en)
|
2020-07-06 |
2023-02-02 |
Janssen Biotech, Inc. |
Prostate Neoantigens And Their Uses
|
US20230338288A1
(en)
|
2020-07-14 |
2023-10-26 |
The Research Foundation For The State University Of New York |
Asymmetric charged vesicles and methods of preparing and use thereof
|
WO2022016089A2
(en)
|
2020-07-17 |
2022-01-20 |
Generation Bio Co. |
Methods for encapsulating polynucleotides into reduced sizes of lipid nanoparticles and novel formulation thereof
|
GB202011367D0
(en)
|
2020-07-22 |
2020-09-02 |
Micropore Tech Limited |
Method of preparing liposomes
|
US20230293434A1
(en)
|
2020-07-23 |
2023-09-21 |
The Regents Of The University Of California |
COMPOSITIONS COMPRISING miR-690 AND METHODS THEREFOR
|
AU2021322310A1
(en)
|
2020-08-06 |
2023-04-13 |
Modernatx, Inc. |
Methods of preparing lipid nanoparticles
|
CA3189854A1
(en)
|
2020-08-06 |
2022-02-10 |
Modernatx, Inc. |
Compositions for the delivery of payload molecules to airway epithelium
|
EP4200330A2
(en)
|
2020-08-19 |
2023-06-28 |
Vitruviae LLC |
Vaccine compositions and antibodies for lyme disease
|
CA3190597A1
(en)
|
2020-08-25 |
2022-03-03 |
Yury Miller |
Compositions and methods for the treatment of ocular neuroinflammation
|
WO2022043551A2
(en)
|
2020-08-31 |
2022-03-03 |
Curevac Ag |
Multivalent nucleic acid based coronavirus vaccines
|
WO2022051866A1
(en)
|
2020-09-11 |
2022-03-17 |
The University Of British Columbia |
Vaccine for viral pathogens
|