BR112015018089A2 - spiro-lactam nmda receptor modulators and uses thereof - Google Patents
spiro-lactam nmda receptor modulators and uses thereofInfo
- Publication number
- BR112015018089A2 BR112015018089A2 BR112015018089A BR112015018089A BR112015018089A2 BR 112015018089 A2 BR112015018089 A2 BR 112015018089A2 BR 112015018089 A BR112015018089 A BR 112015018089A BR 112015018089 A BR112015018089 A BR 112015018089A BR 112015018089 A2 BR112015018089 A2 BR 112015018089A2
- Authority
- BR
- Brazil
- Prior art keywords
- nmda receptor
- spiro
- receptor modulators
- compounds
- lactam
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
resumo moduladores de receptor de nmda de espiro-lactama e usos dos mesmos são divulgados compostos tendo potência intensificada na modulação da atividade de receptor de nmda. tais compostos são contemplados para uso no tratamento de condições tais como depressão e distúrbios relacionados. formulações oralmente disponíveis e outras formas de distribuição farmaceuticamente aceitáveis dos compostos, incluindo formulações intravenosas, são também descritas.Abstract Spiro-lactam nmda receptor modulators and uses thereof Disclosed are compounds having enhanced potency in modulating nmda receptor activity. Such compounds are contemplated for use in treating conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable forms of distribution of the compounds, including intravenous formulations, are also described.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757920P | 2013-01-29 | 2013-01-29 | |
US61/757,920 | 2013-01-29 | ||
PCT/US2014/013621 WO2014120784A1 (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015018089A2 true BR112015018089A2 (en) | 2017-07-18 |
BR112015018089B1 BR112015018089B1 (en) | 2022-09-20 |
Family
ID=50069346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015018089-2A BR112015018089B1 (en) | 2013-01-29 | 2014-01-29 | SPIRO-LACTAMA NMDA RECEPTOR MODULATING COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THEM AND USE THEREOF |
Country Status (17)
Country | Link |
---|---|
US (5) | US9828384B2 (en) |
EP (1) | EP2951182B1 (en) |
JP (1) | JP6531042B2 (en) |
KR (1) | KR102410989B1 (en) |
CN (1) | CN105408336B (en) |
AU (1) | AU2014212485C1 (en) |
BR (1) | BR112015018089B1 (en) |
CA (1) | CA2898774C (en) |
CL (1) | CL2015002122A1 (en) |
EA (1) | EA032153B1 (en) |
HK (1) | HK1218418A1 (en) |
IL (1) | IL240162B (en) |
MX (1) | MX2015009772A (en) |
PE (1) | PE20151427A1 (en) |
PH (1) | PH12015501596A1 (en) |
SG (1) | SG11201505942YA (en) |
WO (1) | WO2014120784A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102186883B (en) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda receptor regulator and its purposes |
BR112015018092A2 (en) | 2013-01-29 | 2017-07-18 | Naurex Inc | spiro-lactam nmda receptor modulators and uses thereof |
MX2015009785A (en) | 2013-01-29 | 2016-04-04 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof. |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
TR201908596T4 (en) | 2013-01-29 | 2019-07-22 | Aptinyx Inc | Spiro-lactam NMDA receptor modulators and their uses. |
CN105408336B (en) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | Spiral shell-lactams nmda receptor conditioning agent and application thereof |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EA201892657A1 (en) | 2016-05-19 | 2019-05-31 | Аптиникс Инк. | SPYROLACTAM MODULATORS OF THE NMDA-RECEPTOR AND THEIR APPLICATION |
MX2019001308A (en) | 2016-08-01 | 2019-05-30 | Aptinyx Inc | Spiro-lactam nmda modulators and methods of using same. |
CN109937204B (en) | 2016-08-01 | 2022-11-25 | 阿普廷伊克斯股份有限公司 | Spiro-lactam NMDA receptor modulators and uses thereof |
EA201990425A1 (en) | 2016-08-01 | 2019-08-30 | Аптиникс Инк. | SPIRO-LACTAM AND BIS-SPIRO-LACTAM MODULATORS OF THE NMDA RECEPTOR AND THEIR APPLICATION |
US10918637B2 (en) | 2016-08-01 | 2021-02-16 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
JP7036792B2 (en) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | Spiro-lactam NMDA receptor modifiers and their use |
WO2019152688A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
MX2020008107A (en) * | 2018-01-31 | 2020-09-25 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof. |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
CA3089559A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152681A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN113966337B (en) * | 2020-05-12 | 2024-01-02 | 北京广为医药科技有限公司 | Compounds that modulate NMDA receptor activity, pharmaceutical compositions and uses thereof |
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MX2015009785A (en) | 2013-01-29 | 2016-04-04 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof. |
BR112015018092A2 (en) | 2013-01-29 | 2017-07-18 | Naurex Inc | spiro-lactam nmda receptor modulators and uses thereof |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN105408336B (en) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | Spiral shell-lactams nmda receptor conditioning agent and application thereof |
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2014
- 2014-01-29 CN CN201480018643.7A patent/CN105408336B/en active Active
- 2014-01-29 WO PCT/US2014/013621 patent/WO2014120784A1/en active Application Filing
- 2014-01-29 US US14/764,402 patent/US9828384B2/en active Active
- 2014-01-29 EP EP14703247.8A patent/EP2951182B1/en active Active
- 2014-01-29 JP JP2015556099A patent/JP6531042B2/en active Active
- 2014-01-29 SG SG11201505942YA patent/SG11201505942YA/en unknown
- 2014-01-29 AU AU2014212485A patent/AU2014212485C1/en active Active
- 2014-01-29 MX MX2015009772A patent/MX2015009772A/en active IP Right Grant
- 2014-01-29 EA EA201591402A patent/EA032153B1/en unknown
- 2014-01-29 CA CA2898774A patent/CA2898774C/en active Active
- 2014-01-29 BR BR112015018089-2A patent/BR112015018089B1/en active IP Right Grant
- 2014-01-29 PE PE2015001568A patent/PE20151427A1/en unknown
- 2014-01-29 KR KR1020157023289A patent/KR102410989B1/en active IP Right Grant
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2015
- 2015-07-20 PH PH12015501596A patent/PH12015501596A1/en unknown
- 2015-07-27 IL IL240162A patent/IL240162B/en active IP Right Grant
- 2015-07-29 CL CL2015002122A patent/CL2015002122A1/en unknown
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2016
- 2016-06-06 HK HK16106443.2A patent/HK1218418A1/en unknown
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2017
- 2017-08-08 US US15/671,409 patent/US20180179218A1/en not_active Abandoned
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2018
- 2018-03-28 US US15/938,040 patent/US20180215767A1/en not_active Abandoned
- 2018-05-02 US US15/968,976 patent/US20180244680A1/en not_active Abandoned
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2020
- 2020-07-02 US US16/919,438 patent/US20210155632A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP6531042B2 (en) | 2019-06-12 |
SG11201505942YA (en) | 2015-08-28 |
IL240162B (en) | 2020-08-31 |
AU2014212485B2 (en) | 2018-04-19 |
US20180215767A1 (en) | 2018-08-02 |
CL2015002122A1 (en) | 2015-12-18 |
PH12015501596A1 (en) | 2015-10-19 |
WO2014120784A1 (en) | 2014-08-07 |
PE20151427A1 (en) | 2015-10-10 |
US9828384B2 (en) | 2017-11-28 |
KR20150110788A (en) | 2015-10-02 |
MX2015009772A (en) | 2016-05-31 |
CA2898774A1 (en) | 2014-08-07 |
CN105408336B (en) | 2018-06-26 |
CN105408336A (en) | 2016-03-16 |
CA2898774C (en) | 2021-07-13 |
HK1218418A1 (en) | 2017-02-17 |
US20180244680A1 (en) | 2018-08-30 |
EA201591402A1 (en) | 2015-12-30 |
BR112015018089B1 (en) | 2022-09-20 |
KR102410989B1 (en) | 2022-06-17 |
NZ709872A (en) | 2020-09-25 |
JP2016506959A (en) | 2016-03-07 |
EP2951182A1 (en) | 2015-12-09 |
US20180179218A1 (en) | 2018-06-28 |
US20150368252A1 (en) | 2015-12-24 |
AU2014212485C1 (en) | 2018-10-25 |
AU2014212485A1 (en) | 2015-07-30 |
EP2951182B1 (en) | 2020-03-18 |
EA032153B1 (en) | 2019-04-30 |
US20210155632A1 (en) | 2021-05-27 |
IL240162A0 (en) | 2015-09-24 |
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