BR112012006693A2 - combinação - Google Patents

combinação

Info

Publication number
BR112012006693A2
BR112012006693A2 BR112012006693A BR112012006693A BR112012006693A2 BR 112012006693 A2 BR112012006693 A2 BR 112012006693A2 BR 112012006693 A BR112012006693 A BR 112012006693A BR 112012006693 A BR112012006693 A BR 112012006693A BR 112012006693 A2 BR112012006693 A2 BR 112012006693A2
Authority
BR
Brazil
Prior art keywords
combination
Prior art date
Application number
BR112012006693A
Other languages
English (en)
Inventor
Melissa Dumble
Peter F Lebowitz
Rakesh Kumar
Shannon Renae Morris
Sylvie Laquerre
Tona Gilmer
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of BR112012006693A2 publication Critical patent/BR112012006693A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BR112012006693A 2009-09-23 2010-09-23 combinação BR112012006693A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24501909P 2009-09-23 2009-09-23
PCT/US2010/049946 WO2011038082A1 (en) 2009-09-23 2010-09-23 Combination

Publications (1)

Publication Number Publication Date
BR112012006693A2 true BR112012006693A2 (pt) 2015-09-08

Family

ID=43796197

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012006693A BR112012006693A2 (pt) 2009-09-23 2010-09-23 combinação

Country Status (14)

Country Link
US (2) US20120322817A1 (pt)
EP (1) EP2480084B1 (pt)
JP (2) JP2013505939A (pt)
KR (1) KR20120099219A (pt)
CN (1) CN102770026B (pt)
AU (1) AU2010298277B2 (pt)
BR (1) BR112012006693A2 (pt)
CA (1) CA2775124A1 (pt)
EA (1) EA021951B1 (pt)
ES (1) ES2527625T3 (pt)
IL (1) IL218797A (pt)
MX (1) MX2012003546A (pt)
WO (1) WO2011038082A1 (pt)
ZA (1) ZA201202173B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130217710A1 (en) * 2010-11-05 2013-08-22 Glaxosmithkline Intellectual Property (No.2) Limited Methods for treating cancer
TWI505828B (zh) 2010-12-20 2015-11-01 葛蘭素史克智慧財產(第二)有限公司 新穎醫藥組成物
CN103841976A (zh) * 2011-04-01 2014-06-04 基因泰克公司 Akt和mek抑制剂化合物的组合及其使用方法
EP2913048A1 (en) 2014-02-27 2015-09-02 ratiopharm GmbH Pharmaceutical composition comprising trametinib
JP2020530498A (ja) * 2017-08-11 2020-10-22 キュアマッチ インコーポレイテッドCurematch, Inc. 癌における複数の変異を標的とする薬物の組み合わせ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1301472T3 (da) * 2000-07-19 2014-04-07 Warner Lambert Co Oxygenerede estere af 4-iod-phenylamino-benzhydroxamsyrer
PL1761528T3 (pl) * 2004-06-11 2008-05-30 Japan Tobacco Inc Pochodne 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pirydo[2,3-D]pirymidyny i związki pokrewne do leczenia raka
US7378423B2 (en) * 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
JP3821154B1 (ja) * 2005-03-16 2006-09-13 いすゞ自動車株式会社 排気ガス浄化方法及び排気ガス浄化システム
UY30892A1 (es) * 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt

Also Published As

Publication number Publication date
KR20120099219A (ko) 2012-09-07
WO2011038082A1 (en) 2011-03-31
EP2480084A4 (en) 2013-02-20
EP2480084B1 (en) 2014-11-12
EP2480084A1 (en) 2012-08-01
JP2013505939A (ja) 2013-02-21
EA021951B1 (ru) 2015-10-30
JP2016106092A (ja) 2016-06-16
EA201270445A1 (ru) 2013-03-29
ES2527625T3 (es) 2015-01-27
CA2775124A1 (en) 2011-03-31
US20150094321A1 (en) 2015-04-02
CN102770026B (zh) 2015-04-01
AU2010298277B2 (en) 2014-07-03
IL218797A0 (en) 2012-06-28
IL218797A (en) 2014-11-30
ZA201202173B (en) 2012-11-28
CN102770026A (zh) 2012-11-07
AU2010298277A1 (en) 2012-04-19
MX2012003546A (es) 2012-09-07
US20120322817A1 (en) 2012-12-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]