BG102287A - New anticonvulsion 1-ar(alk)-imidazolin-2-ons with diasubstituted amine residue in forth place and method for their preparation - Google Patents

New anticonvulsion 1-ar(alk)-imidazolin-2-ons with diasubstituted amine residue in forth place and method for their preparation

Info

Publication number
BG102287A
BG102287A BG102287A BG10228798A BG102287A BG 102287 A BG102287 A BG 102287A BG 102287 A BG102287 A BG 102287A BG 10228798 A BG10228798 A BG 10228798A BG 102287 A BG102287 A BG 102287A
Authority
BG
Bulgaria
Prior art keywords
anticonvulsion
diasubstituted
imidazolin
ons
alk
Prior art date
Application number
BG102287A
Other languages
Bulgarian (bg)
Other versions
BG63917B1 (en
Inventor
Hans-Joachim Lankau
Manfred Menzer
Klaus Unverferth
Karl Gewald
Harry Schaefer
Original Assignee
Elbion Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7771261&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG102287(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Elbion Ag filed Critical Elbion Ag
Publication of BG102287A publication Critical patent/BG102287A/en
Publication of BG63917B1 publication Critical patent/BG63917B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The compounds have anticonvulsion effect. They have thegeneral formulawhere X is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl,halogen and R1, R2, respectively, is C1-C4 alkyl, cycloalkyl orheteroalkyl, n has the value of 0 & 1, and m is 0, 1, 2, 3, 4 & 5.7 claims
BG102287A 1995-09-05 1998-02-27 1-ar(alk)yl-imidazolin-2-ones with disubstituted amine residue in the 4th place, with anti-convulsive effect and method for their preparation BG63917B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19532668A DE19532668A1 (en) 1995-09-05 1995-09-05 Novel, anticonvulsant 1-ar (alk) yl-imidazolin-2-ones which contain a disubstituted amine radical in the 4-position, and process for their preparation
PCT/EP1996/003295 WO1997009314A1 (en) 1995-09-05 1996-07-26 Novel 1-ar(alk)yl-imidazolin-2-ones containing a disubstituted amine radical in the 4th position, having an anti-convulsive effect, and process for their production

Publications (2)

Publication Number Publication Date
BG102287A true BG102287A (en) 1998-09-30
BG63917B1 BG63917B1 (en) 2003-06-30

Family

ID=7771261

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102287A BG63917B1 (en) 1995-09-05 1998-02-27 1-ar(alk)yl-imidazolin-2-ones with disubstituted amine residue in the 4th place, with anti-convulsive effect and method for their preparation

Country Status (32)

Country Link
EP (1) EP0863880B1 (en)
JP (1) JP4030578B2 (en)
CN (1) CN1103762C (en)
AR (1) AR003502A1 (en)
AT (1) ATE254606T1 (en)
AU (1) AU700602B2 (en)
BG (1) BG63917B1 (en)
BR (1) BR9610359A (en)
CA (1) CA2184871C (en)
CZ (1) CZ291839B6 (en)
DE (2) DE19532668A1 (en)
DK (1) DK0863880T3 (en)
EA (1) EA000535B1 (en)
EE (1) EE03562B1 (en)
ES (1) ES2208758T3 (en)
FR (1) FR13C0049I2 (en)
GE (1) GEP20022652B (en)
HK (1) HK1015776A1 (en)
HU (1) HU225956B1 (en)
IL (1) IL123333A (en)
LT (1) LT4482B (en)
LU (1) LU92263I2 (en)
NO (1) NO313829B1 (en)
NZ (1) NZ315624A (en)
PL (1) PL188287B1 (en)
PT (1) PT863880E (en)
SK (1) SK284868B6 (en)
TR (1) TR199800476T1 (en)
TW (1) TW422838B (en)
UA (1) UA46790C2 (en)
WO (1) WO1997009314A1 (en)
ZA (1) ZA967014B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19721580A1 (en) * 1997-05-23 1998-11-26 Dresden Arzneimittel Use of 1-ar (alk) yl-imidazolin-2-one for the treatment of anxiety and tension
US20050070537A1 (en) 2002-10-10 2005-03-31 Chris Rundfeldt Use of dihydroimidazolones for the treatment of dogs
RU2354377C2 (en) * 2003-07-11 2009-05-10 Берингер Ингельхайм Ветмедика Гмбх Method of treatment or prevention of central nervous system diseases by means of compounds possessing selectivity with respect to alpha-3-subunit of benzodiazepine receptor
EP2093218A1 (en) * 2008-02-22 2009-08-26 Ruggero Fariello Arylalkyl substituted imidazolidinones
MX2014001556A (en) 2011-08-12 2014-03-31 Boehringer Ingelheim Vetmed Taste masked pharmaceutical composition.
US9820988B2 (en) 2014-03-24 2017-11-21 Boehringer Ingelheim Vetmedica Gmbh Treatment of epileptic disorders in feline animals
IT202100000782A1 (en) 2021-01-18 2022-07-18 Procos Spa PROCESS FOR THE SYNTHESIS OF IMEPITOIN

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044021A (en) * 1971-10-21 1977-08-23 American Cyanamid Company Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism
BE790380A (en) 1971-10-21 1973-04-20 American Cyanamid Co NEW (P-CHLORO) PHENYL-1 METHYL-3 IMIDAZOLIDINES, 2,4-DISUBSTITUTIONS USEFUL IN PARTICULAR AS ANTIALDOSTERONE DIURETIC AGENTS AND THEIR PREPARATION PROCESS
US3932452A (en) * 1975-02-07 1976-01-13 Morton-Norwich Products, Inc. 1-Arylmethyl-2-imidazolidinones

Also Published As

Publication number Publication date
JPH11512101A (en) 1999-10-19
HUP9802941A2 (en) 1999-09-28
SK21698A3 (en) 1998-10-07
ATE254606T1 (en) 2003-12-15
TR199800476T1 (en) 1998-06-22
CA2184871A1 (en) 1997-03-06
BR9610359A (en) 1999-07-06
HK1015776A1 (en) 1999-10-22
EE03562B1 (en) 2001-12-17
EA199800271A1 (en) 1998-10-29
CZ66198A3 (en) 1998-07-15
NO980906L (en) 1998-03-02
IL123333A (en) 2001-10-31
JP4030578B2 (en) 2008-01-09
DE59610827D1 (en) 2003-12-24
CZ291839B6 (en) 2003-06-18
AR003502A1 (en) 1998-08-05
SK284868B6 (en) 2006-01-05
LT98047A (en) 1998-10-26
EP0863880A1 (en) 1998-09-16
PL325413A1 (en) 1998-07-20
AU6737596A (en) 1997-03-27
NO313829B1 (en) 2002-12-09
PT863880E (en) 2004-04-30
HUP9802941A3 (en) 1999-10-28
CN1103762C (en) 2003-03-26
CA2184871C (en) 2001-08-21
ZA967014B (en) 1997-08-18
UA46790C2 (en) 2002-06-17
WO1997009314A1 (en) 1997-03-13
DE19532668A1 (en) 1997-03-06
ES2208758T3 (en) 2004-06-16
LU92263I2 (en) 2013-10-07
NO980906D0 (en) 1998-03-02
LT4482B (en) 1999-03-25
FR13C0049I2 (en) 2014-03-28
FR13C0049I1 (en) 2013-09-27
TW422838B (en) 2001-02-21
AU700602B2 (en) 1999-01-07
EA000535B1 (en) 1999-10-28
EP0863880B1 (en) 2003-11-19
EE9800063A (en) 1998-08-17
CN1200728A (en) 1998-12-02
BG63917B1 (en) 2003-06-30
GEP20022652B (en) 2002-03-25
DK0863880T3 (en) 2004-03-22
PL188287B1 (en) 2005-01-31
IL123333A0 (en) 1998-09-24
MX9801742A (en) 1998-08-30
HU225956B1 (en) 2008-01-28
NZ315624A (en) 1998-11-25

Similar Documents

Publication Publication Date Title
BG103251A (en) Oxydiazols, methods for their preparation and application as medicamentous forms
IL112495A0 (en) Phenylacetic acid derivatives, their preparation and compositions containing them
AU4159297A (en) Neuropeptide-y ligands
TR199802374T2 (en) Method for obtaining polyalkenamines.
MD1616F2 (en) Tricyclic compounds and method of inhibiting the tyrasin kinases receptors of the epidermal growth factor, pharmaceutical composition, methods of preventing the blastocites implantation and mammals treatment
GB9300763D0 (en) Chemical compound
UA5953A1 (en) Method for synthesizing sulfonylurea derivatives
SI1086096T1 (en) Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
LU92263I2 (en) Imépitoin and its pharmaceutically acceptable derivatives (PEXION)
MY124078A (en) Eletriptan hydrobromide monohydrate
AU696230B2 (en) N-substituted 3-azabicyclo (3.2.0)heptane derivatives, the preparation and use thereof
BG104291A (en) 3-substituted tetrahydropyridopyrimidinone derivatives, method for producing the same, and their use
GB2324091B (en) Metalloproteinase inhibitors
TR200100133T2 (en) FKBP Inhibitors
MX9700813A (en) New 3-substituted 3h-2,3-benzodiazepine derivatives, their preparation and use as medicaments.
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
MX9603199A (en) Endotheline receptors antagonists.
MX9801133A (en) Didepsipeptide-based endoparasiticides, new didepsipeptides and process for preparing the same.
MX9500228A (en) N-oxides of 4-arylpiperazines and 4-arylpiperdines.
MY100938A (en) Arylkylimidazole derivatives.
ZA983231B (en) Substituted benzyloxyimino compounds.
DK0788472T3 (en) Process for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalane derivatives
BG102238A (en) New imidazoline-2,4-dions of anticonvulsion effect containing, in the first place, orthosubstituted ar(alk)yl radical, and method for their preparation
MX9800053A (en) Benzylated cis-2,3-epoxycycloalkanol herbicides.
TW340108B (en) 1,1-difluoro-1,4-dichlorobutane and process for its preparation