AU8400398A - Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use - Google Patents

Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use

Info

Publication number
AU8400398A
AU8400398A AU84003/98A AU8400398A AU8400398A AU 8400398 A AU8400398 A AU 8400398A AU 84003/98 A AU84003/98 A AU 84003/98A AU 8400398 A AU8400398 A AU 8400398A AU 8400398 A AU8400398 A AU 8400398A
Authority
AU
Australia
Prior art keywords
methods
nucleic acid
acid encoding
induced protein
novel chemotherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU84003/98A
Inventor
Wafik S. El-Deiry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of AU8400398A publication Critical patent/AU8400398A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU84003/98A 1997-07-11 1998-07-10 Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use Abandoned AU8400398A (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US5230597P 1997-07-11 1997-07-11
US60052305 1997-07-11
US5471097P 1997-08-04 1997-08-04
US60054710 1997-08-04
US6047397P 1997-09-30 1997-09-30
US60060473 1997-09-30
US7766198P 1998-03-11 1998-03-11
US7762898P 1998-03-11 1998-03-11
US7752698P 1998-03-11 1998-03-11
US60077526 1998-03-11
US60077661 1998-03-11
US60077628 1998-03-11
PCT/US1998/014495 WO1999002653A1 (en) 1997-07-11 1998-07-10 Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use

Publications (1)

Publication Number Publication Date
AU8400398A true AU8400398A (en) 1999-02-08

Family

ID=27556648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU84003/98A Abandoned AU8400398A (en) 1997-07-11 1998-07-10 Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use

Country Status (2)

Country Link
AU (1) AU8400398A (en)
WO (1) WO1999002653A1 (en)

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US7452538B2 (en) 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US6433147B1 (en) 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
US8329179B2 (en) 1997-01-28 2012-12-11 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
US6342363B1 (en) 1997-01-28 2002-01-29 Human Genome Sciences, Inc. Death domain containing receptor 4 nucleic acids and methods
US7528239B1 (en) 1997-02-13 2009-05-05 Immunex Corporation Receptor that binds trail
US6072047A (en) 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
CA2373063A1 (en) * 1999-05-06 2000-11-16 Jian Ni Death domain containing receptor 4
ATE511857T1 (en) 2000-02-16 2011-06-15 Genentech Inc ANTI-APRIL MONOCLONAL ANTIBODIES AND THEIR USE IN THE TREATMENT OF IMMUNE DISEASES OR CANCER
NZ521540A (en) 2000-04-11 2004-09-24 Genentech Inc Multivalent antibodies and uses therefor
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
WO2002009755A2 (en) 2000-07-27 2002-02-07 Genentech, Inc. Apo-2l receptor agonist and cpt-11 synergism
US7064189B2 (en) 2001-05-25 2006-06-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
EP1409544B1 (en) 2001-07-03 2009-06-17 Genentech, Inc. Human dr4 antibodies and uses thereof
JP2005508162A (en) 2001-10-02 2005-03-31 ジェネンテック・インコーポレーテッド Apo-2 ligand variants and methods of use
WO2003038087A1 (en) 2001-10-04 2003-05-08 Kansai Technology Licensing Organization Co., Ltd. DR5 GENE PROMOTER AND Siah-1 GENE PROMOTER
ES2351786T3 (en) 2001-11-13 2011-02-10 Genentech, Inc. FORMULATIONS WITH BINDING APO2 / TRAIL AND USES OF THE SAME.
US7842668B1 (en) 2001-11-13 2010-11-30 Genentech, Inc. Apo-2 ligand/trail formulations
US7741285B2 (en) 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
CA2489348A1 (en) 2002-06-24 2003-12-31 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof
CN1980957A (en) 2004-03-23 2007-06-13 比奥根艾迪克Ma公司 Receptor coupling agents and therapeutic uses thereof
CA2575755C (en) 2004-08-06 2014-04-08 Genentech, Inc. Assays and methods using biomarkers
RU2431676C2 (en) 2004-08-06 2011-10-20 Дженентек, Инк. Analyses and methods with application of biomarkers
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
BRPI0606791A2 (en) 2005-02-02 2010-02-09 Uab Research Foundation methods of reversing or preventing the resistance of a cell to a death receptor agonist, of screening a cell for a biomarker of resistance to a death receptor agonist, of monitoring resistance to a death receptor agonist in an individual , to selectively induce apoptosis in a target cell expressing a death receptor, to treat an individual with cancer, to treat an individual with an inflammatory or autoimmune disease, to block the binding of the card-containing protein to a death receptor in a cell, to block the association of an iap with the death receptor and to screen a modulator of a protein containing card, composition, isolated nucleic acid, vector, cell, and isolated polypeptide
ES2380119T3 (en) 2005-08-16 2012-05-08 Genentech, Inc. Apoptotic sensitivity to APO2L / TRAIL by analyzing the expression of GalNac-T14 in cells / tissues
PE20071101A1 (en) 2005-08-31 2007-12-21 Amgen Inc POLYPEPTIDES AND ANTIBODIES
AU2006318539B2 (en) 2005-11-23 2012-09-13 Genentech, Inc. Methods and compositions related to B cell assays
WO2010042890A2 (en) 2008-10-10 2010-04-15 Anaphore, Inc. Polypeptides that bind trail-ri and trail-r2
BR112012010698A2 (en) 2009-11-05 2016-11-29 Uab Research Foundation method for treating a subject with cancer, method for screening a breast cancer cell, and antibody
WO2011116344A2 (en) 2010-03-18 2011-09-22 The Uab Research Foundation Targeting cancer stem cells
DK2636736T3 (en) 2010-10-29 2016-07-04 Daiichi Sankyo Co Ltd Novel anti-dr5 antibody
EP2681238A2 (en) 2011-02-28 2014-01-08 Istituto di Ricovero E Cura A Carattere Scientifico Materno-Infantile Burlo Garofolo- Ospedale di Alta Specializzazione E di Rilievo Apoptosis-inducing molecules and uses therefor
WO2012151317A1 (en) 2011-05-03 2012-11-08 Genentech, Inc. Vascular disruption agents and uses thereof
ME02917B (en) 2013-03-14 2018-10-20 Bristol Myers Squibb Co Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
EP3323428A1 (en) 2016-11-17 2018-05-23 CNRS Centre National de la Recherche Scientifique Selective c-flip inhibitors as anticancer agents
EP3910331A1 (en) 2020-05-15 2021-11-17 iOmx Therapeutics AG Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof
CN114395030A (en) * 2021-12-27 2022-04-26 长沙学院 Recombinant protein for regulating intestinal health of fish and preparation method and application thereof
EP4257132A1 (en) 2022-04-08 2023-10-11 iOmx Therapeutics AG Sik3 inhibitors for treating diseases resistant to death receptor signalling

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101004174B1 (en) * 1995-06-29 2010-12-24 임뮤넥스 코포레이션 Cytokine that induces apoptosis
AU1461197A (en) * 1995-11-16 1997-06-05 Icos Corporation Cell cycle checkpoint pik-related kinase materials and methods

Also Published As

Publication number Publication date
WO1999002653A9 (en) 1999-04-15
WO1999002653A1 (en) 1999-01-21

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase