AU777898B2 - Method for producing film-type dosage forms - Google Patents
Method for producing film-type dosage forms Download PDFInfo
- Publication number
- AU777898B2 AU777898B2 AU31514/00A AU3151400A AU777898B2 AU 777898 B2 AU777898 B2 AU 777898B2 AU 31514/00 A AU31514/00 A AU 31514/00A AU 3151400 A AU3151400 A AU 3151400A AU 777898 B2 AU777898 B2 AU 777898B2
- Authority
- AU
- Australia
- Prior art keywords
- drying
- stage
- temperature
- process according
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/79—Fixation, conservation, or encapsulation of flavouring agents in the form of films
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Manufacturing & Machinery (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Cosmetics (AREA)
- General Preparation And Processing Of Foods (AREA)
- Laminated Bodies (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Wrappers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Process for the production of sheet-like administration forms The present invention relates to sheet-like administration forms for application as cosmetic, pharmaceutical or foodtechnological products.
Flat-shaped administration forms for use in the oral region and on the mucous membranes of the mouth are well-known.
Thus, US 3 444 858 (Russell, 1969) already describes medicament strips based on a gelatine-like material.
In EP 0 216 762 a water-soluble film of starch, gelatine, glycerine or sorbite is disclosed which is coated employing a roll-coating method. The document shortly mentions in this context that such dosage forms can also be produced for chemical reagents, flavours and the like.
ooooo goOD A formulation that is in principal suitable for making eoooo sheet-like systems is disclosed in EP 0 460 588. Here, the composition of 20 to 60 percent by weight of film former, 2 to 40% gelatinizing agent, 0.1 t 35 percent by weight of active substance (here: flavouring agent) and a maximum of oooo percent by weight of an inert filler is regarded as affording particular advantages.
DE 36 30 603 sees particular advantages in designing the flat-shaped dosage form on a carrier material (release film) so as to peelable in doses.
film) so as to peelable in doses.
US 4 128 445 and 4 197 289 (Sturzenegger, 1978) address possible technical solutions in connection with the loading with active substances.
For drug-containing sheet-like systems a two-layer structure of a water-swellable layer and a water-insoluble barrier film is also regarded as advantageous (US 5 047 244).
In the manufacture of such films, some hydrophile film formers, especially pullulan and other glucans, but also cellulose derivatives, exhibit insufficient wetting on common coating media. This may result in premature or difficult substrate detachment as well as a resultant uneven film thickness. As a remedy, US 4 562 020 recommends the use of a substrate circulating in the process as a loop, said substrate being based on nonpolar heat-stable polymers and, during the process, being continuously subjected to a superficial corona treatment, thus being constantly provided with a new polar surface that has a sufficiently safe wetting capability. The drying temperatures are between and 110°C; temperatures mentioned in the Examples are and The aroma films produced on the pure film substrates have proved disadvantageous because of their being smooth on both sides. Such products have only limited suitability for the further processing and use in stacks formed by film cutting. Such stacks of film pieces or punched film pieces, as are frequently offered to the consumer in suitable dosage dispensers, tend to stick to each other, which makes it much more difficult to safely remove the pieces. As such film-shaped administration forms, due to their small weight per unit area (typically approx. 10 to 80 g/m 2 tend to become statically charged, and since, at the same time, their surfaces, to facilitate later removal, are designed so as to be slidable on each other, this aspect is disturbing not only in use but also in the process technology.
A third demand that should be met by the process is that loss of flavour due to heat be prevented while affording maximum process rates. The prior art reveals no information pointing towards a solution to this demand.
From these requirements, which have as yet remained unsolved in the prior art, results the object of the present invention of providing processes for making sheet-like active substance carriers which enable a precise and reproducible coating quality, prevent the mutual adhesion of the finally produced pieces of film or sheet in the stack, and can be obtained, while avoiding contamination and excessive thermal load, at high production rates.
oooo A first embodiment of the invention comprises a process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate, characterized in that a relative substrate humidity (equivalent air humidity) of 50 to 75% relative humidity, preferably 60 to 68% relative humidity, is maintained during the drying process, and the drying is conducted in three stages, wherein the temperature in the first drying stage is between 30 and 50 0 C, the temperature in the second drying stage is between 35 and 80 0 C, the temperature in the third drying ooo* 3a stage is between 25 and 50 0 C, and the temperature of the second stage is higher than the temperature of the first stage and the temperature of the third stage is lower than the temperature of the second stage.
Preferably, immediately subsequent to the coating of the solution of hydrophile polymers with added active substances and further auxiliary substances, a stream of moderately warm air (30 50 0 C) is passed over the material, whereafter the temperature is raised slightly (35 80°C), finally followed by a reconditioning phase at 25 50 0 C. The process rate is advantageously regulated such that a relative substrate humidity (equivalent humidity or equivalent
C
*o
*C*
*C*
4 air humidity) of 50 75% relative humidity, preferably 68% relative humidity, is maintained in all cases.
By using rough-surface substrates, preferably thermoplasts of polypropylene, polyethylene, polyethylene terephthalate, polycarbonate, and laminates of these polymers, with polyethylene-coated paper being particularly preferred, it is effectively prevented that the later-produced single film pieces stick to each other in a stack.
The process according to the invention is applicable to any form of flat-shaped products for example, for use as a food stuff, medicament or a cosmetic which can be produced in a coating process from a mass which has been fluidized by solvents, especially water, and contains solid, hydrophile base substances and optionally further components.
These hydrophile base substances may be polymers such as starch and its derivatives, agar-agar, gelatine, cellulose and cellulose derivatives, alginic acid, galactoglucomannan, carrageen, other vegetable gums permitted for the respective field of application, pullulan and other glucans, dextrane, and polyvinylpyrrolidone, polyvinyl alcohol or polyacrylic acid homopolymers and copolymers. The polyvinyl alcohol used is advantageously a partially hydrolised form wherein between 1 and 20%, especially preferred: approximately 12%, of the hydroxyl groups are replaced by acetyl groups.
acetyl groups.
The process according to the invention is effective in particular with problematic masses containing high portions of pullulan, carrageen or cellulose esters.
Hydrophile additives of small molecular weight may also be employed, as structure-forming agents; these mostly serve to achieve application-specific objects. Possible additives are, inter alia, sugar, sugar alcohols, sugar substitutes, organic acids, polyethylene glycol.
Solid substances which due to their poor solubility do not form a molecular-disperse mixture or solution in the base material may also be contained. Suitable substances are, for example, carbonates, phosphates, silicates, or sulfates of the alkali earth metals, zinc oxide, titanium oxide or other colour pigments, talcum, lactose, cyclodextrins or starch and starch derivatives, as far as they form their own, solid, disperse phase in the final product.
oo The above list is exemplary only and can be completed by substances of the same function known to those skilled in *oo.
the art.
Active components may, for example, be medicinal or cosmetic active agents, dietary additives to foods, colourants o •o or diagnostics. In particular, the process according to the invention can be employed with flavouring agents which are ooze o otherwise difficult to process because of their volatility.
The flavours which may be used with this invention are mainly essential oils (volatile, water-insoluble distillates of fragrant components of plants) and other volatile, fragrant substances having a limited miscibility with water. Examples therefor are phenyl ethanol as a component of rose fragrance aromatics, menthol, eucalyptol (cineole), camphene and pinene in peppermint-like fresh flavourings, appetite inducing flavourings (spicing aromatics) such as, for example, n-butylphthalide or cineole, but also flavours having medicinal applications, such as eucalyptus oil, thyme oil, methyl salicylate, terpentine oil and camomile oil.
A very broad field is taken up by essences and aromatics which are being used as additives in foods, and in prefabricated food additives. Examples for these are the socalled fruit ethers, but also other aromatics such as ethyl vanillin, 6-methylcoumarin, citronellol or n-butyl acetate.
Additives of surface-active substances can improve the uniformity of the distribution of the droplets of aromatics.
In special cases it may prove to be of advantage to apply one or more further layers of equal or different composition, in order to obtain special surface or tensile properties, for example.
The mass is prepared, for example, by strewing-in, kneading-in or slowly digesting the solid components in the solvent (typically water, but also, ethanol, acetone and other compatible, physiologically acceptable solvents and mixtures thereof are employed). To this phase is added, while stirring slowly, the pre-weighed amount of flavouring agent and other liquid, lipophile additives, as far as provided by the recipe.
In the interest of the object of the invention, it has turned out to be of great advantage with respect to a uniform constitution to homogenize the mass, prior to coating, on a high-speed homogenizer.
In the process according to the invention, the mass is coated on a substrate using a spread-coating, knife-coating or extrusion method, and is dried in a drying canal consisting of at least three independently temperaturecontrolled zones.
The substrate may in principle consist of substrates known to those skilled in the art and widely used, such as, for instance, polyethylene terephthalate, polyethylene, polypropylene, polycarbonate, polyurethane. Also used are laminates of these substances with other polymers, paper, fibreglass, and other structure-forming materials for increasing tensile strength. To regulate surface adhesion it may be useful to take measures such as siliconization, fluorination, acid treatment or corona treatment, but these require clarification of their physiological tolerance for the relevant purpose of application in each individual case.
o* .i Special advantages are achieved according to the invention S" if the surface facing towards the coating mass does not have a smooth contour, but a contoured, dulled, and in any case rough-surface contour. The peak-to-valley height can be in the range of 0.1 pm to about 10 pm, preferably between 0.5 and 3 pm. Of advantage are rounded protrusions in 0* the microstructure, which further reduce sliding friction.
0 The object of the present invention is regularly achieved where the drying takes place at a process temperature which where the drying takes place at a process temperature which 8 rises initially and is then, in the last zone at the latest, reduced by 10 *C.
Advantageously, the process rate is to be adjusted such that a product having an equivalent humidity of 50 relative humidity, preferably 60 68% relative humidity, is obtained.
Under these process conditions the products obtained proved surface-stable, flexible and break-resistant as well as largely tear-resistant. The resultant surfaces exhibit virtually no "cold flow" and are thus basically dimensionally stable. The film can be removed from the support without perceptible elongation occurring, and can be further processed separately.
The equivalent air humidity is determined as follows: A freshly prepared product strip of about 0.1 m 2 in area is immediately and quickly folded, using rubber gloves, and placed in a wide-neck glass vessel, the cover of which is provided with a through-bore such that the measuring head ooooo Sof a hygrometer is introduced therein. After about a min- S. ute, depending on the construction of the device, the meas- Sured value can be read.
55 The further processing takes place, after longitudinal sec- 5555 tion, in punching devices or simply by transverse section.
S
The sheet-like products produced preferably have a thickness of between 20 and 300 ym; their size may advantageously range from 0.5 to 12 cm 2 Subsequent packaging may SOi take place singly or in a stack, for example in sealed pouches or dosage dispensers.
pouches or dosage dispensers.
Claims (9)
1. Process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate, characterized in that a relative substrate humidity (equivalent air humidity) of 50 to relative humidity, preferably 60 to 68% relative humidity, is maintained during the drying process, and the drying is conducted in three stages, wherein the temperature in the first drying stage is between 30 and 50 0 C, the temperature in the second drying stage is between 35 and 80 0 C, the temperature in the third drying stage is between 25 and 50 0 C, and the temperature of the second stage is higher than the temperature of the first stage and the temperature of the third stage is lower than the temperature of the second stage.
2. Process according to claim i, characterized in that the sheet-like product contains flavours.
3. Process according to claim 1 or 2, characterized in that the sheet-like product contains pullulan as main component. *o ao
4. Process according to one or more of the preceding claims, characterized in that the drying of the laminate takes place in the first temporal third of the drying stage at between 30 and 0 C, in the second third at between 35 and 80 0 C, and in the last third at between 25 and 50 0 C. eo
5. Process according to one or more of the preceding claims, Scharacterized in that said solvent-containing, spreadable mass see* a *oIa a a a is coated onto the rough surface of a rough-surface substrate, and dried.
6. Process according to claim 5, characterized in that a polyethylene-coated paper is used as the material having a rough surface.
7. A process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate, said process being substantially as herein described with reference to the detailed description.
8. An administration form made in accordance with the process as claimed in any one of claims 1 7.
9. Process according to any one of claims 1 to 8, characterized in that the relative substrate humidity is maintained within the specified range by regulating the process rate of the drying process. Dated this 1st day of September 2004 LTS LOHMANN THERAPIE-SYSTEME AG q 0 9 S. S S b U~ 9 5 00 50000 S 00 0 00 0 0 HODGKINSON AND McINNES Patent Attorneys for the Applicant
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19905801 | 1999-02-12 | ||
DE19905801A DE19905801B4 (en) | 1999-02-12 | 1999-02-12 | Process for the preparation of film-shaped dosage forms |
PCT/EP2000/000739 WO2000047190A2 (en) | 1999-02-12 | 2000-01-31 | Method for producing film-type dosage forms |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3151400A AU3151400A (en) | 2000-08-29 |
AU777898B2 true AU777898B2 (en) | 2004-11-04 |
Family
ID=7897244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU31514/00A Ceased AU777898B2 (en) | 1999-02-12 | 2000-01-31 | Method for producing film-type dosage forms |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1150663A2 (en) |
JP (1) | JP2002536402A (en) |
KR (1) | KR100620068B1 (en) |
CN (1) | CN1147293C (en) |
AR (1) | AR022580A1 (en) |
AU (1) | AU777898B2 (en) |
BR (1) | BR0009962B1 (en) |
CA (1) | CA2362756C (en) |
CZ (1) | CZ301872B6 (en) |
DE (1) | DE19905801B4 (en) |
HK (1) | HK1039069A1 (en) |
HU (1) | HUP0202877A2 (en) |
IL (2) | IL144767A0 (en) |
MX (1) | MXPA01007867A (en) |
NO (1) | NO20013892D0 (en) |
NZ (1) | NZ513465A (en) |
PL (1) | PL202678B1 (en) |
RU (1) | RU2226389C2 (en) |
TR (1) | TR200102056T2 (en) |
TW (1) | TWI254725B (en) |
WO (1) | WO2000047190A2 (en) |
ZA (1) | ZA200106580B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10114509A1 (en) * | 2001-03-23 | 2002-10-02 | Haarmann & Reimer Gmbh | Production of encapsulated product fixed to surface, by applying mixture of film-forming polymer, core material (especially fragrance or aroma) and organic solvent to surface and drying |
ES2294180T3 (en) * | 2001-12-11 | 2008-04-01 | Ceapro Inc. | BETA-GLUCANO COMPOSITIONS OF CEREALS, PREPARATION METHODS AND USES OF THE SAME. |
EP2663294B1 (en) | 2011-01-11 | 2015-09-30 | Capsugel Belgium NV | New hard capsules comprising pullulan |
JP2020516653A (en) | 2017-04-14 | 2020-06-11 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップCapsugel Belgium NV | Pullulan capsule |
EP3610028A1 (en) | 2017-04-14 | 2020-02-19 | Capsugel Belgium NV | Process for making pullulan |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5456745A (en) * | 1988-08-13 | 1995-10-10 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Flexible, hydrophilic gel film, the process for its production and the use of it |
WO1995029664A1 (en) * | 1994-05-03 | 1995-11-09 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
AU5654898A (en) * | 1996-12-16 | 1998-07-15 | Lts Lohmann Therapie-Systeme Gmbh | Individually dosed active substance-containing and, in particular, aromatic(s)-containing film-shaped administration form rapidly disintegrating upon contact with a liquid |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6055039A (en) * | 1983-09-07 | 1985-03-29 | Mitsubishi Acetate Co Ltd | Water-soluble polysaccharide film |
DE3333240A1 (en) * | 1983-09-12 | 1985-03-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | MEDIUM FOR TRANSDERMAL APPLICATION OF MEDICINAL PRODUCTS |
JPH0744940B2 (en) * | 1986-12-24 | 1995-05-17 | ライオン株式会社 | Base material for oral application |
-
1999
- 1999-02-12 DE DE19905801A patent/DE19905801B4/en not_active Expired - Fee Related
-
2000
- 2000-01-27 TW TW089101364A patent/TWI254725B/en not_active IP Right Cessation
- 2000-01-31 MX MXPA01007867A patent/MXPA01007867A/en not_active IP Right Cessation
- 2000-01-31 TR TR2001/02056T patent/TR200102056T2/en unknown
- 2000-01-31 CZ CZ20012900A patent/CZ301872B6/en not_active IP Right Cessation
- 2000-01-31 BR BRPI0009962-7A patent/BR0009962B1/en not_active IP Right Cessation
- 2000-01-31 NZ NZ513465A patent/NZ513465A/en not_active IP Right Cessation
- 2000-01-31 AU AU31514/00A patent/AU777898B2/en not_active Ceased
- 2000-01-31 CA CA002362756A patent/CA2362756C/en not_active Expired - Fee Related
- 2000-01-31 RU RU2001118268/15A patent/RU2226389C2/en not_active IP Right Cessation
- 2000-01-31 KR KR1020017010143A patent/KR100620068B1/en not_active IP Right Cessation
- 2000-01-31 EP EP00909123A patent/EP1150663A2/en not_active Ceased
- 2000-01-31 JP JP2000598143A patent/JP2002536402A/en active Pending
- 2000-01-31 IL IL14476700A patent/IL144767A0/en active IP Right Grant
- 2000-01-31 PL PL349857A patent/PL202678B1/en unknown
- 2000-01-31 HU HU0202877A patent/HUP0202877A2/en unknown
- 2000-01-31 WO PCT/EP2000/000739 patent/WO2000047190A2/en not_active Application Discontinuation
- 2000-01-31 CN CNB008028656A patent/CN1147293C/en not_active Expired - Fee Related
- 2000-02-11 AR ARP000100610A patent/AR022580A1/en active IP Right Grant
-
2001
- 2001-08-07 IL IL144767A patent/IL144767A/en not_active IP Right Cessation
- 2001-08-09 NO NO20013892A patent/NO20013892D0/en not_active Application Discontinuation
- 2001-08-10 ZA ZA200106580A patent/ZA200106580B/en unknown
-
2002
- 2002-01-31 HK HK02100760.6A patent/HK1039069A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5456745A (en) * | 1988-08-13 | 1995-10-10 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Flexible, hydrophilic gel film, the process for its production and the use of it |
WO1995029664A1 (en) * | 1994-05-03 | 1995-11-09 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
AU5654898A (en) * | 1996-12-16 | 1998-07-15 | Lts Lohmann Therapie-Systeme Gmbh | Individually dosed active substance-containing and, in particular, aromatic(s)-containing film-shaped administration form rapidly disintegrating upon contact with a liquid |
Also Published As
Publication number | Publication date |
---|---|
NO20013892L (en) | 2001-08-09 |
PL202678B1 (en) | 2009-07-31 |
JP2002536402A (en) | 2002-10-29 |
WO2000047190A2 (en) | 2000-08-17 |
DE19905801A1 (en) | 2000-08-17 |
AU3151400A (en) | 2000-08-29 |
TWI254725B (en) | 2006-05-11 |
EP1150663A2 (en) | 2001-11-07 |
NO20013892D0 (en) | 2001-08-09 |
WO2000047190A3 (en) | 2000-12-14 |
KR20010102050A (en) | 2001-11-15 |
HUP0202877A2 (en) | 2003-03-28 |
BR0009962A (en) | 2002-04-16 |
RU2226389C2 (en) | 2004-04-10 |
ZA200106580B (en) | 2002-02-14 |
KR100620068B1 (en) | 2006-09-05 |
HK1039069A1 (en) | 2002-04-12 |
NZ513465A (en) | 2003-05-30 |
TR200102056T2 (en) | 2001-11-21 |
CZ301872B6 (en) | 2010-07-14 |
CN1147293C (en) | 2004-04-28 |
CA2362756C (en) | 2009-11-24 |
CA2362756A1 (en) | 2000-08-17 |
MXPA01007867A (en) | 2002-07-02 |
BR0009962B1 (en) | 2014-07-29 |
AR022580A1 (en) | 2002-09-04 |
IL144767A0 (en) | 2002-06-30 |
IL144767A (en) | 2006-08-20 |
PL349857A1 (en) | 2002-09-23 |
CZ20012900A3 (en) | 2002-01-16 |
CN1336820A (en) | 2002-02-20 |
DE19905801B4 (en) | 2008-03-13 |
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