AU6144698A - Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells - Google Patents

Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells

Info

Publication number
AU6144698A
AU6144698A AU61446/98A AU6144698A AU6144698A AU 6144698 A AU6144698 A AU 6144698A AU 61446/98 A AU61446/98 A AU 61446/98A AU 6144698 A AU6144698 A AU 6144698A AU 6144698 A AU6144698 A AU 6144698A
Authority
AU
Australia
Prior art keywords
bfgf
bmp
stem cells
mesenchymal stem
osteogenic differentiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU61446/98A
Inventor
Arnold I. Caplan
James E. Dennis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of AU6144698A publication Critical patent/AU6144698A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/14—Ceramic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
AU61446/98A 1997-02-05 1998-02-04 Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells Abandoned AU6144698A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3711997P 1997-02-05 1997-02-05
US60037119 1997-02-05
PCT/US1998/002143 WO1998033515A1 (en) 1997-02-05 1998-02-04 STIMULATORY EFFECTS OF bFGF AND BMP-2 ON OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS

Publications (1)

Publication Number Publication Date
AU6144698A true AU6144698A (en) 1998-08-25

Family

ID=21892533

Family Applications (1)

Application Number Title Priority Date Filing Date
AU61446/98A Abandoned AU6144698A (en) 1997-02-05 1998-02-04 Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells

Country Status (2)

Country Link
AU (1) AU6144698A (en)
WO (1) WO1998033515A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3185599A (en) * 1998-03-14 1999-10-11 Curis, Inc. Compositions for modulating cell differentiation comprising a lipid and a morphogen
AU2004200550B2 (en) * 1999-07-28 2006-07-20 Interface Biotech A/S Cell cultivation method for the preparation of chondroblasts/chondrocytes
DE60018576T2 (en) * 1999-07-28 2006-04-13 Interface Biotech A/S IN VITRO HEALING OF BONE AND / OR TROUBLE DAMAGE
EP1379268A1 (en) * 2001-02-23 2004-01-14 Genetics Institute, LLC Chondrogenic potential of human bone marrow-derived cd105?+ cells by bmp
EP1619242A4 (en) * 2003-03-25 2006-09-06 Japan Science & Tech Agency Control of stem cell differentiation induction and differentiation potency
WO2005001079A2 (en) 2003-06-27 2005-01-06 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells
WO2005065704A1 (en) * 2004-01-09 2005-07-21 Saitama Medical School Preventive and remedy for bone disease
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
PT1989295T (en) 2006-02-16 2020-10-29 Univ Bruxelles A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof
US20100278788A1 (en) * 2008-01-11 2010-11-04 Bone Therapeutics, S.A. Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
US20170241990A1 (en) * 2014-07-18 2017-08-24 Case Western Reserve University Pericyte assay for transendothelial migration
CN110938669B (en) * 2019-12-20 2023-03-28 南昌大学第二附属医院 Verification method for stimulating osteogenic differentiation of valve interstitial cells by inorganic phosphate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells

Also Published As

Publication number Publication date
WO1998033515A1 (en) 1998-08-06

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