AU3539089A - Ligase-based amplification method - Google Patents

Ligase-based amplification method

Info

Publication number
AU3539089A
AU3539089A AU35390/89A AU3539089A AU3539089A AU 3539089 A AU3539089 A AU 3539089A AU 35390/89 A AU35390/89 A AU 35390/89A AU 3539089 A AU3539089 A AU 3539089A AU 3539089 A AU3539089 A AU 3539089A
Authority
AU
Australia
Prior art keywords
ligase
amplification method
based amplification
amplification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35390/89A
Inventor
Leslie E. Orgel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of AU3539089A publication Critical patent/AU3539089A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6862Ligase chain reaction [LCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU35390/89A 1988-04-08 1989-04-07 Ligase-based amplification method Abandoned AU3539089A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17947888A 1988-04-08 1988-04-08
US179478 1988-04-08

Publications (1)

Publication Number Publication Date
AU3539089A true AU3539089A (en) 1989-11-03

Family

ID=22656760

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35390/89A Abandoned AU3539089A (en) 1988-04-08 1989-04-07 Ligase-based amplification method

Country Status (2)

Country Link
AU (1) AU3539089A (en)
WO (1) WO1989009835A1 (en)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
DE68927373T2 (en) * 1988-06-24 1997-03-20 Amgen Inc METHOD AND MEANS FOR DETECTING NUCLEIC ACID SEQUENCES
US6004826A (en) * 1988-07-20 1999-12-21 David Segev Repair-mediated process for amplifying and detecting nucleic acid sequences
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US6013431A (en) * 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and reagent for determining specific nucleotide variations
DK0528882T3 (en) * 1990-05-03 2008-01-14 Cornell Res Foundation Inc DNA amplification system for detection of genetic diseases by thermostable ligase
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5439793A (en) * 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
CA2049879A1 (en) * 1990-08-30 1992-03-01 Keith C. Backman Controlled initial target-dependent production of templates for ligase chain reaction
GB9112251D0 (en) * 1991-06-07 1991-07-24 Amersham Int Plc Quantitative detection of nucleic acid amplification products
DK0519338T3 (en) 1991-06-20 1996-10-28 Hoffmann La Roche Improved Methods for Nucleic Acid Amplification
DE4129653A1 (en) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh PROCESS FOR DETECTION OF SIMILAR NUCLEIC ACIDS
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US6100099A (en) 1994-09-06 2000-08-08 Abbott Laboratories Test strip having a diagonal array of capture spots
US5869252A (en) * 1992-03-31 1999-02-09 Abbott Laboratories Method of multiplex ligase chain reaction
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US5593826A (en) * 1993-03-22 1997-01-14 Perkin-Elmer Corporation, Applied Biosystems, Inc. Enzymatic ligation of 3'amino-substituted oligonucleotides
DE69424541T2 (en) * 1993-03-22 2000-12-14 Perkin Elmer Corp ENZYMATIC LIGATION OF 3'-AMINO SUBSTITUTED OLIGONUCLEOTIDES
US6406841B1 (en) 1993-07-01 2002-06-18 Abbott Laboratories Methods for the detection of HTLV-II antibodies employing novel HTLV-II NRA envelope peptides
PL316611A1 (en) * 1994-04-04 1997-01-20 Ciba Corning Diagnostics Corp Hybrisdisation/ligation tests for determining specific sequences of nucleic acids
DE69531612D1 (en) * 1994-04-25 2003-10-02 Avitech Diagnostics Inc DETERMINATION OF MUTATIONS BY CUTTING WITH RESOLVASE
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
US5631130A (en) * 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
EP0803058B1 (en) * 1994-12-30 2008-11-05 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US6113905A (en) * 1995-01-06 2000-09-05 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6077510A (en) * 1995-01-06 2000-06-20 Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
US6015660A (en) * 1995-01-06 2000-01-18 The Regents Of The University Of California Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases
DE69605803T2 (en) * 1995-05-11 2000-07-20 Ulf Landegren DETECTION OF MALFUNCTIONS BY CUTTING WITH A RESOLVASE ON A SOLID CARRIER
US6436638B1 (en) 1996-05-09 2002-08-20 Metropolitan Water District Of Southern California Cryptosporidium detection method
US5770368A (en) * 1996-05-09 1998-06-23 Metropolitan Water District Of Southern California Cryptosporidium detection method
WO1999040222A1 (en) * 1998-02-04 1999-08-12 Variagenics, Inc. Mismatch detection techniques
AU3274500A (en) * 1999-03-18 2000-10-09 Exiqon A/S Detection of mutations in genes by specific lna primers
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
ATE413467T1 (en) 1999-04-20 2008-11-15 Illumina Inc DETECTION OF NUCLEIC ACID REACTIONS ON BEAD ARRAYS
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
AU2002246612B2 (en) 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
AU2003303395A1 (en) 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
EP1481076A4 (en) 2001-07-12 2005-05-11 Illumina Inc Multiplex nucleic acid reactions
US9045796B2 (en) 2003-06-20 2015-06-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
KR20060052710A (en) * 2003-07-03 2006-05-19 더 리전트 오브 더 유니버시티 오브 캘리포니아 Genome mapping of functional dna elements and cellular proteins
EP1756562A1 (en) 2004-05-21 2007-02-28 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
CN100583434C (en) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
EP1955241B1 (en) 2005-11-14 2011-03-30 Gen-Probe Incorporated Parametric calibration method
US7981606B2 (en) 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
CN103443338B (en) 2011-02-02 2017-09-22 华盛顿大学商业化中心 Massively parallel continguity mapping
EP2877952B1 (en) 2012-07-27 2023-04-12 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
AU2013382195B2 (en) 2013-03-13 2019-09-19 Illumina, Inc. Methods and systems for aligning repetitive DNA elements
CA2898456C (en) 2013-03-13 2020-11-10 Illumina, Inc. Methods and compositions for nucleic acid sequencing
JP6463332B2 (en) 2013-03-15 2019-01-30 ジェン−プローブ・インコーポレーテッド Calibration method, apparatus and computer program product
AU2014364180B2 (en) 2013-12-09 2021-03-04 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
EP3957750A1 (en) 2013-12-20 2022-02-23 Illumina, Inc. Preserving genomic connectivity information in fragmented genomic dna samples
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
WO2015108663A1 (en) 2014-01-16 2015-07-23 Illumina, Inc. Amplicon preparation and sequencing on solid supports
EP3670664B1 (en) 2014-02-28 2022-09-07 Gen-Probe Incorporated Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
GB2559919B (en) 2014-02-28 2018-11-14 Gen Probe Inc Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
CN117867071A (en) 2014-06-13 2024-04-12 伊卢米纳剑桥有限公司 Methods and compositions for preparing sequence libraries
ES2713153T3 (en) 2014-06-30 2019-05-20 Illumina Inc Methods and compositions that use unilateral transposition
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
CN107002121B (en) 2014-09-18 2020-11-13 亿明达股份有限公司 Methods and systems for analyzing nucleic acid sequencing data
KR102643955B1 (en) 2014-10-17 2024-03-07 일루미나 케임브리지 리미티드 Contiguity preserving transposition
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
EP3783109B1 (en) 2015-03-31 2024-05-29 Illumina Cambridge Limited Surface concatamerization of templates
WO2016164407A2 (en) 2015-04-07 2016-10-13 Polyskope Labs Detection of one or more pathogens
CN115261468A (en) 2015-07-06 2022-11-01 伊卢米纳剑桥有限公司 Sample preparation for nucleic acid amplification
CN108463287B (en) 2016-03-28 2021-01-15 亿明达股份有限公司 Multiplanar microarrays
DK3488002T3 (en) 2016-07-22 2021-06-21 Univ Oregon Health & Science SINGLE CELL WEEKEND LIBRARIES AND COMBINATORY INDEXING METHODS FOR PREPARING IT
US10995369B2 (en) 2017-04-23 2021-05-04 Illumina, Inc. Compositions and methods for improving sample identification in indexed nucleic acid libraries
CN110785492B (en) 2017-04-23 2024-04-30 伊鲁米纳剑桥有限公司 Compositions and methods for improved sample identification in indexed nucleic acid libraries
CA3059952C (en) 2017-04-23 2023-04-18 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
ES2898250T3 (en) 2017-06-07 2022-03-04 Univ Oregon Health & Science Single cell whole genome libraries for methylation sequencing
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
AU2018312560B2 (en) 2017-08-01 2022-03-10 Illumina, Inc. Hydrogel beads for nucleotide sequencing
KR20220123327A (en) 2018-02-13 2022-09-06 일루미나, 인코포레이티드 DNA sequencing using hydrogel beads
KR102383799B1 (en) 2018-04-02 2022-04-05 일루미나, 인코포레이티드 Compositions and methods for preparing controls for sequence-based genetic testing
WO2019204229A1 (en) 2018-04-20 2019-10-24 Illumina, Inc. Methods of encapsulating single cells, the encapsulated cells and uses thereof
BR112020005982A2 (en) 2018-05-17 2020-12-08 Illumina, Inc. HIGH PERFORMANCE SINGLE CELL SEQUENCING WITH REDUCED AMPLIFICATION BIAS
JP6986103B2 (en) 2018-06-04 2021-12-22 イルミナ インコーポレイテッド High-throughput single-cell transcriptome library and how to make and use it
CN113272449B (en) 2018-10-26 2024-03-12 Illumina公司 Polymer beads are adapted for DNA treatment
BR112021006183A2 (en) 2018-11-30 2021-06-29 Illumina, Inc. analysis of multiple analytes using a single assay
KR20210134598A (en) 2019-03-01 2021-11-10 일루미나, 인코포레이티드 High-throughput single-nuclear and single-cell libraries and methods of making and using same
JP2022539630A (en) 2019-07-12 2022-09-13 イルミナ ケンブリッジ リミテッド Preparation of nucleic acid libraries using electrophoresis
BR112021012755A2 (en) 2019-07-12 2022-04-26 Illumina Cambridge Ltd Compositions and methods for preparing nucleic acid sequencing libraries using crispr/cas9 immobilized on a solid support
EP4361284A3 (en) 2019-12-09 2024-05-29 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
KR20220118295A (en) 2019-12-19 2022-08-25 일루미나, 인코포레이티드 High Throughput Single Cell Libraries, and Methods of Making and Using the Same
US20230105642A1 (en) 2020-03-30 2023-04-06 Illumina, Inc. Method and compositions for preparing nucleic acid libraries
CA3177286A1 (en) 2020-05-12 2021-11-18 Illumina Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
KR20230037503A (en) 2020-06-30 2023-03-16 일루미나, 인코포레이티드 Sequencing by catalytically controlled synthesis to generate traceless DNA
BR112023002051A2 (en) 2020-08-06 2023-04-18 Illumina Inc PREPARATION OF RNA AND DNA SEQUENCING LIBRARIES USING MICROSPHERE-ATTACHED TRANSPOSOMES
CN116323971A (en) 2020-08-18 2023-06-23 Illumina公司 Sequence-specific targeted transposition and selection and sorting of nucleic acids
CN116323970A (en) 2020-09-11 2023-06-23 伊鲁米纳剑桥有限公司 Method for enriching target sequences from sequencing libraries using hairpin adaptors
EP4288562A1 (en) 2021-02-04 2023-12-13 Illumina, Inc. Long indexed-linked read generation on transposome bound beads
BR112023019894A2 (en) 2021-03-29 2023-11-14 Illumina Inc COMPOSITIONS AND METHODS FOR ASSESSING DNA DAMAGE IN A LIBRARY AND NORMALIZING AMPLICON SIZE DISTORTION
JP2024511766A (en) 2021-03-29 2024-03-15 イルミナ インコーポレイテッド Improved library preparation method
KR20230161955A (en) 2021-03-30 2023-11-28 일루미나, 인코포레이티드 Improved methods for isothermal complementary DNA and library preparation
IL307164A (en) 2021-03-31 2023-11-01 Illumina Inc Methods of preparing directional tagmentation sequencing libraries using transposon-based technology with unique molecular identifiers for error correction
CA3223722A1 (en) 2022-04-07 2023-10-12 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024073659A1 (en) 2022-09-30 2024-04-04 Biotheranostics, Inc. Biomarker assay to select breast cancer therapy
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663283A (en) * 1980-03-24 1987-05-05 Genentech, Inc. Method of altering double-stranded DNA
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences

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