AU2012203941A1 - New method for salt preparation - Google Patents

Abstract

C.\NRPortbI\DCC\XT\4449943_l.DOC-5107/2012 The present invention provides a new method for preparation and crystallization of hydrochlorides, hydrobromides or hydroiodides of pharmaceutical compounds or their intermediates in which the base or its acid addition salt is reacted in a solvent with a 5 trialkylsilylhalogenide.

Description

Australian Patents Act 1990- Regulation 3.2A ORIGINAL COMPLETE SPECIFICATION STANDARD PATENT Invention Title "New method for salt preparation" The following statement is a full description of this invention, including the best method of performing it known to me/us:- 1 NEW METHOD FOR SALT PREPARATION FIELD OF THE INVENTION The present invention provides a new method for preparation and crystallization of hydrohalides of 5 pharmaceutical compounds or their intermediates. According to the present process hydrohalides may be obtained in a reliable way with good yield and in pure form consisting of a defined crystal structure. The process of the present Invention is especially well suitable for industrial use . BACKGROUND OF THE INVENTION 10 Hydrochlorides of pharmaceutical compounds or their Intermediates are usually prepared by acidification of a solution of a base or a salt thereof with hydrogen chloride whereby aqueous hydrogen chloride or gaseous hydrogen chloride is used or a solution of HCl in an organic solvent. The preparation of hydrochlorides by addition of aqueous hydrochloric acid is a straightforward process and hydrochloric acid is conveniently used as the 36% (w/w) solution in water. A typical procedure is to 15 dissolve the organic base in a solvent and to add the calculated volume or an excess of concentrated HCI and if crystallization does not occur, it can be induced by progressive additions of an organic solvent like diethyl ether. However salt formation by aqueous hydrochloric acid is often characterized by lower yields due to solubility of the hydrochloride salt in water. Furthermore if anhydrous salt forms are desired, the use of aqueous hydrochloric acid is not feasible in many cases. If water interferes with 20 the formation and Isolation of a solid crystalline product, it is possible to use the anhydrous gas from cylinders or HCI gas in an anhydrous aprotic solvent like diethyl ether. But the alternative use of gaseous hydrogen chloride on a large scale gives rise to high equipment costs and typical risks of gas handling. Very often it Is important to produce a hydrochloride in a pure form consisting of a single crystal 25 structure. This is of particular Importance for pharmaceutical drug substance because variations in crystal structure may affect the dissolution, manufacturability and stability of a pharmaceutical drug product, specifically in a solid oral dosage form formulation. But the preferential formation of a desired form of a hydrochloride depends on crystallization kinetics and is not easy to control. Sometimes a constant flow of gaseous hydrogen chloride within a certain time is necessary and the temperature has 30 to be kept substantially constant during the gas flow and even during filtering the product, making the process very difficult to handle. A purpose of the present Invention is to provide a suitable method to prepare hydrochlorides, hydrobromides or hydrolodides of pharmaceutical compounds or their Intermediates in a reproducible manner and in a pure form consisting of a defined crystal structure. 35 2 SUMMARY OF THE INVENTION The present Invention provides a new method for preparation and crystallization of hydrohalides of pharmaceutical compounds or their intermediates. According to the present process hydrohalides may be obtained in a reliable way with good yield and in pure form consisting of a defined crystal structure. 5 The process of the present invention is especially well suitable for industrial use . In particular, the present invention relates to a process for the preparation of a crystalline hydrohalide of an organic amine wherein a trialkylsyihalogenide is added to the organic amine in a solvent, which organic amine is in the form of the free base or an acid addition salt, wherein the conjugated acid of the acid addition salt Is weaker than the hydrohalogenic acid. 10 It further relates to a Moxifloxacin hydrochloride methylene dichloride solvate, a new anhydrous form IV of Moxifloxacin hydrochloride, a Moxifloxacin hydrochloride nitromethane solvate, a Moxifloxacin hydrochloride acetic acid solvate, pharmaceutical compositions comprising an effective amount of the anhydrous form IV of Moxifloxacin HCI or of the acetic acid solvate of Moxifloxacin HCI, a new crystalline form of Linezolid hydrochloride, a Prasugrel hydrochloride acetonitrile solvate and a 15 Raloxifene hydrochloride tetrahydrofuran solvate, all new solvates or salts being obtainable by the process of the invention. The invention further relates to the use of trialkylsilylhalogenide in a process for the preparation of a crystalline hydrohalide of an organic amine. BRIEF DESCRIPTION OF THE DRAWINGS 20 Figure 1A: X-ray powder diffraction pattern of anhydrous Mycophenolate Mofetil hydrochloride. Figure 1 B: Infrared spectrum of anhydrous Mycophenolate Mofetil hydrochloride. Figure IC: DSC curve of anhydrous Mycophenolate Mofetil hydrochloride. Figure 2A: X-ray powder diffraction pattern of Venlafaxine hydrochloride form I. Figure 2B: Infrared spectrum of Venlafaxine hydrochloride form I. 25 Figure 3k X-ray powder diffraction pattern of Venlafaxine hydrochloride form 1l. Figure 38: Infrared spectrum of Venlafaxine hydrochloride form 1I. Figure 4k X-ray powder diffraction pattern of Sertraline hydrochloride form 11. Figure 4B: Infrared spectrum of Sertraline hydrochloride form 11. Figure 5k X-ray powder diffraction pattern of Sertraline hydrochloride form I. 30 Figure SB: Infrared spectrum of Sertraline hydrochloride form 1. Figure 6k X-ray powder diffraction pattern of Donepezil hydrochloride form II. Figure 66: Infrared spectrum of Donepezil hydrochloride form 1I. Figure 7k X-ray powder diffraction pattern of Donepezil hydrochloride form Ill. Figure 7B: Infrared spectrum of Donepezil hydrochloride form Ill. 35 Figure 8k X-ray powder diffraction pattern of Terbinafine hydrochloride. Figure 88: Infrared spectrum of Terbinafine hydrochloride form. Figure 9k X-ray powder diffraction pattern of Cinacalcet hydrochloride.

3 Figure 9B: Infrared spectrum of Cinacalcet hydrochloride. Figure 1 OA X-ray powder diffraction pattern of Citalopram hydrobromide. Figure 101: Infrared spectrum of Citaloprarn hydrobromide. Figure 1 IA: X-ray powder diffraction pattern of Aripiprazole hydrochloride form A. 5 Figure 11 B: Infrared spectrum of Aripiprazole hydrochloride form A. Figure 12A: X-ray powder diffraction pattern of Pramipexole Monohydrochloride. Figure 128: Infrared spectrum of Pramipexole Monohydrochlorlde. Figure 13k X-ray powder diffraction pattern of Moxifloxacin hydrochloride methylene dichloride solvate 10 Figure 13B: Infrared spectrum of Moxifloxacin hydrochloride methylene dichloride solvate. Figure 13C: 'H-NMR spectrum (DMSO-d6, TMS) of Moxifloxacin hydrochloride methylene dichloride solvate. Figure 14A: X-ray powder diffraction pattern of anhydrous Moxifloxacin hydrochloride form IV. Figure 14B: Infrared spectrum of anhydrous Moxifloxacin hydrochloride form IV. 15 Figure 15k X-ray powder diffraction pattern of Moxifloxacin hydrochloride acetic acid solvate. Figure 15B: Infrared spectrum of Moxifloxacin hydrochloride acetic acid solvate. Figure 16C: I H-NMR spectrum (DMSO-d6, TMS) of Moxifloxacin hydrochloride acetic acid solvate. Figure 16A: X-ray powder diffraction pattern of Moxifloxacin hydrochloride nitromethane solvate. Figure 16B: Infrared spectrum of Moxifloxacin hydrochloride nitromethane solvate. 20 Figure 16C: 1 H-NMR spectrum (DMSO-d6. TMS) of Moxifloxacin hydrochloride nitromethane solvate. Figure 17A: X-ray powder diffraction pattern of Duloxetine hydrochloride. Figure 17B: Infrared spectrum of Duloxetine hydrochloride. Figure 18k X-ray powder diffraction pattern of Unezolid hydrochloride. Figure 188: Infrared spectrum of Unezolid hydrochloride. 25 Figure 19k X-ray powder diffraction pattern of Memantine hydrochloride. Figure 196: Infrared spectrum of Memantine hydrochloride. Figure 20k X-ray powder diffraction pattern of Rimonabant Hydrochloride form 1. Figure 206: Infrared spectrum of Rimonabant Hydrochloride form I. Figure 21A: X-ray powder diffraction pattern of Clopidogrel Hydrochloride form 1. 30 Figure 21B: Infrared spectrum of Clopidogrel Hydrochloride form I. Figure 22A: X-ray powder diffraction pattern of Clopidogrel Hydrobromide form A. Figure 226: Infrared spectrum of Clopidogrel Hydrobromide form A. Figure 23A: X-ray powder diffraction pattern of Prasugrel Hydrochloride form B. Figure 236: Infrared spectrum of Prasugrel Hydrochloride form B. 35 Figure 24A: X-ray powder diffraction pattern of Prasugrel Hydrochloride acetonitrile solvate. Figure 24B: Infrared spectrum of Prasugrel Hydrochloride acetonitrile solvate. Figure 25A: X-ray powder diffraction pattern of Raloxifene Hydrochloride form A. Figure 256: Infrared spectrum of Raloxifene Hydrochloride form A.

4 Figure 26k X-ray powder diffraction pattern of Raloxifene Hydrochloride tetrahydrofurane solvate. Figure 26B: Infrared spectrum of Raloxifene Hydrochloride tetrahydrofurane solvate. Figure 27A- X-ray powder diffraction pattern of Olanzapine Dihydrochloride form 1. Figure 27B: Infrared spectrum of Olanzapine Dihydrochioride form 1. 5 Figure 28A: X-ray powder diffraction pattern of Darifenacin Hydrobromide. Figure 28B: Infrared spectrum of Darifenacin Hydrobromide. Figure 29A: X-ray powder diffraction pattern of Sitagliptine Hydrochloride in amorphous form. Figure 29B: Infrared spectrum of Sitagliptine Hydrochloride in amorphous form. Figure 30A: X-ray powder diffraction pattern of VardenafU Dihydrochloride. 10 Figure 30B: Infrared spectrum of Vardenafil Dihydrochloride. Figure 31k X-ray powder diffraction pattern of Ertotinib Hydrochloride form A Figure 31 B: Infrared spectrum of Erlotinib Hydrochloride form A. 15 DETAILED DESCRIPTION OF THE INVENTION The present Invention relates to the discovery that trialkyisilylhalogenides are very well suited for the preparation of hydrohalide salts of basic drug substances or hydrohalide salts of basic intermediates, especially in cases where anhydrous conditions are required and/or In cases where a well defined crystalline structure of the salt in pure form has to be prepared. 20 The invention thus relates to a process for the preparation of a crystalline halogenide of an organic amine wherein a trialkysilylhalogenide is added to the organic amine in a solvent, which organic amine Is in the form of the free base or an acid addition salt, wherein the conjugated acid of the acid addition salt Is weaker than the hydrohalogenic acid. 25 Suitable solvents for the process of the present Invention are protic solvents or aprotic solvents in combination with at least one equivalent of a protic solvent compared to the organic amine. Protic solvents are solvents which are silylable i.e. which have the ability to generate In situ an hydrohalide when added to a trialkylsilyhalogenide. Suitable protic solvents are e.g. aliphatic alcohols 30 or aromatic alcohols, slanoils, ketones capable of enolizatilon, or aliphatic or aromatic carbonic acids. Aprotic solvents are solvent which are inert to silylation capable of dissolving or suspending the amine or directing the defined crystal structure of the hydrohalide formed. Suitable aprotic solvents are e.g. ester, especially ethyl-acetate; nitriles, especially acetonitrile; Ketone, especially acetone; ethers, especially tertlobutylmethylether; Halogenated solvents, especially 35 dichloromethane; Aromatic solvents, especially toluene; Alkanes. especially hexane; and nirtroalkenes, especially nitromethane. An organic amine within the meaning of the present Invention is an organic compound comprising a primary, secondary, tertiary or quaternary amino group and more than three carbon-carbon bonds and 5 having a molecular weight of more than 80Da, preferably having a molecular weight of between 100Da and 5000Da. In one embodiment the process of the invention comprises the steps of: 5 (a) dissolving the free base of the organic amine or suspending, preferably with stirring; of the free base of the organic amine In a protic solvent, (b) adding the trialkyisilylhalogenide. (c) allowing the crystals of the crystals (hydrohalide of the organic amine) to form and, (d) collecting the crystals formed. 10 In preferred embodiments the invention this process Is used for the production of moxifloxacin hydrochloride acetic acid solvate, citalopram hydrobromide, dopidrogel hydrobromide, raloxifene hydrochloride form A or erlotinib hydrochloride form A, for example as further detailed below. 15 During step (b) the halogensilane reacts immediately as silylating agent, presumably with the protic solvent, thereby generating hydrohalogenic acid In situ, and the generated HCI, HBr or HI converts the free-base to the hydrogen halide. Step (d) can be carried out by any suitable method In the art, e.g. by filtration. 20 Preferred trialkyisilylhalogenides are those where the three alkyl residues are identical, in particular where they are methyt, ethyl, propyl, butyl or isopropyl. Most preferred trialkylhalogenides are trimethylchorosflane. trimethylbromosilane and trimethyliodosilane. The term "protic solvent' as used In the present invention includes solvent systems which are mixtures 25 of solvents where the total amount of protic solvents Is more than one molequivalent compared to the organic amine to be added, in particular wherein the total amount of protic solvents Is about one molequivalent of the organic amine to be added. Preferred protic solvents used In step (a) are solvents comprising a hydroxyl group or a carboxyl group. 30 Particularly preferred protic solvents are aromatic or aliphatic alcohols, slianols, ketones capable of enolization, or aromatic or aliphatic carbonic acids, or solvent systems which are mixtures thereof. More preferred protic solvents are C1 -C6 alkyl alcohols, like methanol, ethanol, 2-propanol (isopropanol), butanol (such as n-butanol and Isobutanol); or C1-C6 alkylcarboxylc acid, in particular formic acid or acetic acid. 35 Workup and Isolation of the hydrohalides, including drying, may be carried out using methods known In the art.

6 In a further embodiment, the process for preparing a hydrohalide salt of an organic compound comprises the steps of : a) dissolving the free base of the organic amine in an aprotic solvent to form a solution or stirring a suspension of the free base In an aprotic solvent. 5 b) adding at least one equivalent, in particular adding about one equivalent, of a protic solvent to the solution or suspension formed in step a), In particular wherein the preferred protic solvent is as defined above, c) treating the solution or suspension of step b) with at least one equivalent, In particular with about one equivalent, of a rialkylsilylhalogenide, in particular with a preferred trialkylhalogenide as defined above, 10 to form the corresponding hydrohalide salt, d) allowing the crystals of the hydrohalide salt of the organic amine to form and, e) collecting the formed crystals. Step e) can be carried out by any suitable method in the art, e.g. by filtration. 15 In preferred embodiments the invention this process Is used for, e.g., the production of sertraline hydrochloride form Il, aripirazol hydrochloride. pramipexole monohydrochlorilde, menantine hydrochloride. rimonabant hydrochloride form I, clopidrogel hydrochloride form I, clopidrogel hydrobromide form A. prasugrel hydrochloride form A, prasugrel hydrochloride acetonitrie solvate, 20 raloxifene hydrochloride tetrahydrofuran hemisolvate, olanzapine dihydrochloride form I, darifenacin hydrobromide, sitagliptin hydrochloride or vardenafil dlhydrochloride, for example as further detailed below. When aprotic solvents are used, the free base of the organic amine itself can react with the 25 trialkylhalogenide to form a sUylated hydrogen halide and the silylated product can be hydrolyzed afterwards by addition of one or more equivalents of a protic step like an alcohol. Thus, the order of steps b) and c) can be reversed. Also, the trialkylhalogenide can first be mixed with the protic solvent to generate the hydrohalogenic acid and this mixture can then be added to the dissolved or suspended organic amine. 30 In a further embodiment the process for preparing a hydrohalide salt of an organic compound comprises the steps of: (a) dissolving, suspending or generating the acid addition salt of the organic amine In a solvent. (b) the trialkyisilylhalogenide Is added, 35 (c) allowing the crystals of the hydrohalide salt of the organic amine to form and, (d) collecting the formed crystals. Step d) can be carried out by any suitable method in the art, e.g. by filtration.

7 in preferred embodiments the invention this process Is used for, e.g., the production of sertraline hydrochloride form II, raloxifene hydrochloride form A or raloxifene hydrochloride tetrahydrofuran hemisolvate, for example as further detailed below. 5 In step (a) the acid addition salt of the organic amine can be generated in situ by adding the organic acid to the solution or suspension of the base In the solvent The organic acid used for generation of the organic acid salt of the amine should be weaker than hydrochloric acid and preferably Is selected from the group consisting of substituted or unsubstituted 10 alkanolo acids, aromatic carboxylic acids, dicarboxylic acids or citric acid, with acetic acid being particularly preferred. Preferably in step (a) the acid addition salt of the organic amine is generated in situ by adding an acid, which conjugated acid is weaker than hydrochloric acid and preferably is an organic acid, to a solution 15 or slurry of the organic amine. In preferred embodiments of the invention this process is used for, e.g., the production of mycophenolate mofetil hydrochloride in its crystalline anhydrous form, venlafaxine hydrochloride form 1. venlafaxine hydrochloride form 1i, sertraline hydrochloride form II, donepezl hydrochloride form ill, 20 terbinafine hydrochloride, cinacalcet hydrochloride, moxifloxacin hydrochloride methylene dichloride solvate, moxifloxacine hydrochloride nitromethane solvate, moxifloxacine hydrochloride acetic acid solvate, cbialopram hydrobromide, duloxetine hydrochloride or linezorid hydrochloride, for example as further detailed below. 25 Hydrochlorides have been by far the most frequent choice for salts of basic drugs because of the easy availability and for physiological tolerability, and about half the salts of all drugs are hydrochlorides, and serve as an example for all hydrohalides In the following paragraph. The formation of hydrochlorides does sometimes require strictly anhydrous conditions and especially in 30 this case it is advantageous to use trialkylsiylchloride for generating hydrochloric acid in situ and for inducing salt formation as described above. At other times formation of hydrochlorides requires a defined stoichiometry of HCI in relation to the organic amine, which Is very easy to achieve by use of trialkylsilylchloride as described above. Even if only an exact calculated amount of an hydrohalogenic acid in a solvent is needed, the use of a trialkylsilylhalogenide is easier and a better method than the 35 preparation of the solution via anhydrous gas from cylinders. In other words, the use of trialkylsilylhalogenides for in situ generation of hydrohalogenic acid in the process of the invention allows a very good control of the stoichiometric ratio of hydrohalogenic acid 8 and organic amine during salt formation. This is of particular advantage when there exist two or more hydrohalides of an organic amine, for example a monohydrohalide and a dihydrohalide, as in this case choosing the amount of hydrohalogenic acid to be generated can direct the process towards obtaining the desired hydrohalide. For example, if one desires to obtain a monohydrohalide, but there exists also 5 a competing dihydrohalide, then one can limit the amount of added trialkylsilyihalogenide so that only one molequivalent of hydrohalogenid acid is generated in situ and thus steer crystallization towards generation of the monohydrohalide. A further advantage of the process of the invention is that it can also operate at the virtual absence of 10 water so that anhydrous forms of the hydrohalide salts of the organic amines become accessible. Moreover, since the addition of the trialkylsilylhalogenide is a very robust step and can be effected within a broad temperature range and is compatible with a broad diversity of solvent systems, addition of the trialkylsilyhalogenide can most of the times be effected at those very conditions that are known to be optimal for obtaining a desired crystal form. For example, if it Is known that polymorphic form A of 15 a monohydrochloride of drug X is obtainable at low temperatures in solvent Y, while polymorphic form B of the same monohydrochloride is obtainable at ambient temperature on solvent Z, then one can simply choose the conditions so that the desired form, be it A or B, forms, for the very reason that the robust nature of the trialkylsilylhalogenide addition step allows to make this choice of crystallization conditions. 20 In a further embodiment, the process of the Invention is employed for the generation of hydrohalides of drugs with a primary, secondary, tertiary or quaternary amino group, in particular wherein the drug is selected from an antidepressant, like the serotonin reuptake inhibitors Sertraline, Duloxetine, Venlafaxine and Citalopram, a nootropic agent, like in particular Donepezil, an antipsychotic agent, like 25 in particular the neuroleptic Aripiprazole and the serotonin/dopamine antagonist Olanzapine, a muscle relaxant, like in particular the antispasmodic agent Memantine, an immunosuppressant, like in particular Mycophenolate Mofetil, an antifungal agent, like in particular Terbinafine, an antibacterial, like in particular a Quinolone, as for example Moxifloxacin or the oxazolidinone Linezolid, a calcimimetic agent, like in particular Cinacalcet, a Dopamine agonist, like in particular the D2-receptor agonist 30 Pramipexole, an antiobesity agent, like Rimonabant, an antithrombotic like Clopidogrel and Prasugret, an antlosteoporotic, like in particular Raloxifene, an antispasmodic like Darifenacin, an agent for treatment of male erectile dysfunction like Vardenafil, an antidiabetic, like in particular the DPP-IV inhibitor Sitagliptin, an antineoplastic like Erlotinib. 35 In a further embodiment, the invention relates to the preparation of crystalline anhydrous Mycophenolate Mofetil hydrochloride by a process of the invention, in particular a process which comprises 9 a) dissolving Mycophenolate Mofetil base in ethyl acetate, acetonitrile or acetone, in particular in ethyl acetate, b) adding acetic acid, In particular 1.0 to about 1.5 equivalents equivalent of acetic acid, and c) treating the solution with a trisflylalkylchlorosilane, in particular with about 1.0 to about 1.5 equivalents of Trimethylchlorosilane. 5 With this process, anhydrous Mycophenotate Mofetil hydrochloride precipitates and can be Isolated in over 97% yield. FT-IR, DSC and XRPD data of the crystalline product correspond to IR DSC and X-ray crystallography data as shown In WO 95/07902. WO 95/07902 discloses that anhydrous Mycophenolate Mofetil hydrochloride possesses about a two-fold increase in solubility over the monohydrate salt form, while possessing the stability characteristics of the monohydrate salt form. The 10 present method avoids the formation of the monohydrate hydrochloride thus circumventing the need to heat Mycophenolate Mofetil hydrochloride Monohydrate in order to prepare the anhydrous form. In a further embodiment, the Invention relates to the preparation of Venlafaxine hydrochloride by a process of the invention. in particular to a process for the preparation of Venlafaxine hydrochloride 15 Form I or Form II in pure form wherein gaseous hydrogen chloride is not used during the process. In a preferred embodiment, the Invention relates to a process for the preparation of Venlafaxine hydrochloride Form I, which process comprises the steps of a) dissoMng Venlafaxine base In ethyl acetate, b) adding acetic acid, in particular adding 1.0 to about 1.5 equivalents equivalent of acetic acid, and c) treating the solution with about 1.0 to about 1.5 equivalents of Trimethylchlorosilane. 20 By this process anhydrous Venlafaxine hydrochloride Form I precipitates and can be Isolated In over 890/ yield. XRPD data of the crystalline product correspond to X-ray crystalography data Form I as shown in WO 02/45658 (Teva) and Form B as shown in WO 02/36542 (Ciba). In another preferred embodiment, the Invention relates to a process for the preparation of Venlafaxine 25 hydrochloride Form 11 which process comprises the steps of a) dissolving Venlafaxine base in acetone or acetonitrile as solvent, b) adding acetic acid, in particular adding 1.0 to about 1.5 equivalents equivalent of acetic acid, and c) treating the solution with about 1.0 to about 1.5 equivalents of Trimethylchlorosilane. By this process anhydrous Venlafaxine hydrochloride Form Il is obtained. XRPD data of the crystalline product correspond to X-ray crystallography data Form 11 as shown In WO 30 02145658 (Teva) and Form C as shown in WO 02136542 (Ciba). In a further embodiment, the invention relates to the preparation of Sertraline hydrochloride Form |1 by a process of the invention. Sertraline hydrochloride Form 11 is a metastable form and Is usually produced by rapid crystallization of Sertraline hydrochloride from an organic solvent. However the 35 preferential formation of form 11 depends on the rapidity of crystallization which is not easily controllable. Therefore there is a need for the preparation of Sertraline hydrochloride form II. The process of the present invention allows the Industrial preparation of this metastable form 11 In pure form and In a simple way. The present invention therefore also relates to Sertraline hydrochloride form |1 10 without detectable levels of sertraline form I, that is less than 1.0% form I, in particular less than 0.5% form I. as determined by the absence of a suitable XRPD peak characteristic for form I alone, for example at 14.9 and 26.3 2 theta. Therefore, in one embodiment, the Invention relates to a process for preparing Sertraline hydrochloride 5 Form |1 which comprises: a) dissolving Sertraline free base in an aprotic solvent, for example acetone. methyl ethyl ketone, methyl isobutyl ketone or acetonitrile, b) adding 1.0 to about 1.5 equivalents equivalent of a protic solvent, like n-butanol or acetic acid, to the solution of step a) 10 c) treating the solution of step b) with an trialkylsiylchloride. for example Trimethylchorosllane. Trimethylchlorosilane can be added all at once or can be added in two or more portions, or can be added Incrementally. The reaction with Trimethylchlorosilane can be conducted at any temperature at which Sertraline Is soluble. In acetonitrile as solvent, the reaction is typically conducted at a temperature in the range of from about 20 to 80'C, and more typically at a temperature in the range of 15 from about 20 to 50*C. In methyl isobutyl ketone as solvent the reaction is conducted at a temperature in the range of from about 50 to 100*C. and more typically at a temperature of about 80*C. Trimethyichlorosilane Is typically added in an amount of about 1 to about 2 equivalents of Trimethylchlorosllane per equivalent of Sertrallne. The protic solvent In step b) Is typically added In an amount equivalent to the amount of Trimethylchlorosilane used. Following the addition of 20 Trimethylchlorosllane, the reaction mixture can be aged for a period of time to permit Intimate mixing. In another preferred embodiment the Invention relates to a process for preparing Sertraline hydrochloride Form 11 using an organic salt of Sertrallne which comprises a) stirring a suspension of an organic salt of Sertraline, for example the mandelate or oxalate salt, in an 25 aprotic solvent, for example methyl ethyl ketone, methyl isobutyl ketone or acetonitrile, b) treating the suspension with a trialkyisilylchloride, for example trimethylchlorosllane. In methyl ethyl ketone as solvent typically the reaction with Trimethylchlorosilane is conducted at a temperature In the range of from about 50 to 80*C, and In methyl Isobutyl ketone as solvent the reaction is conducted at a temperature In the range of from about 50 to 1OC and more, typically at a 30 temperature of about 80'C. In acetonitrile as solvent, the reaction with Trimethylchlorosilane can be conducted even at ambient temperature. Trimethylchlorosilane is typically added In an amount of from about 1 to about 2 equivalents of Trimethylchlorosilane per equivalent of the organic salt and more typically in an amount of 1,1 equivalents per equivalent of the organic salt 35 The present invention further relates to a process for preparing Sertrallne hydrochloride Form I which comprises a) dissolving Sertraline free base in isopropanol at room temperature and b) treating the solution with Trimethylchlorosilane.

11 The present invention further relates to a process of the invention for preparing anhydrous Donepezil hydrochloride. Depending on the choice of solvent, Donepezil hydrochloride Form 11 or Form IlIl can be made. 5 In a first embodiment this is a process to prepare Donepezil hydrochloride Form I which comprises: a) dissolving the Donepezil free base in ethyl acetate. dimethoxyethane or methyl Isobutyl ketone, b) adding at least one equivalent of a protic solvent, for example n-butanol or acetic acid c) treating the solution with at least one equivalent of Trimethylchlorosilane, d) isolation of Donepezil hydrochloride Form 11 10 In a second embodiment this is a process to prepare anhydrous Donepezil hydrochloride Form Ill, wherein acetone or acetonitrile Is used as solvent XRPD data of the crystalline product Donepezil hydrochloride Form || and Donepezil hydrochloride Form IlIl correspond to X-ray crystallography data of Form |1 and Form Ill as shown in WO 97146527 (Elsal). 15 The present invention further relates to a process for preparing Terbinafine hydrochloride. Cinacalcet hydrochloride. Duloxetine hydrochloride, Memantine hydrochloride and Pramipexole Monohydrochloride according to a process of the invention, which process preferably comprises a) dissolving the free base of Terbinafine, Cinacalcet, Duloxetine, Memantine or Pramlpexole In an aprotic solvent, 20 b) adding at least one equivalent of a protic solvent, for example acetic acid or an alcohol like methanol or n-butanol, c) treating the solution with at least one equivalent of Trimethylchlorosilane. In the above process, Terbinafine can be dissolved for example in an aprotic solvent like acetone, 25 acetonitrile or tert.-butyi methyl ether, Cinacalcet can be dissolved for example in an aprotic solvent like acetonitrile or ethyl acetate. and Pramipexole can be dissolved for example in an aprotic solvent like acetonitrile. XRPD data of the crystalline product Terbinafine hydrochloride correspond to X-ray crystallography data published by E. Tedesco et al. in CrystEngComm, 2002, 4(67), 393-400. A characteristic X-ray 30 powder diffraction pattern of the crystalline hydrochloride salt of Cinacalcet is shown In Figure 9A and a characteristic X-ray powder diffraction pattern of the crystalline hydrochloride salt of Pramipexole is shown in Figure 12A. In addition, the crystalline hydrochloride salt of Cinacalcet Is also characterized by a typical Infrared spectrum as shown In Figure 96 and the crystalline Pramipexole Monohydrochloride is characterized by a typical Infrared spectrum as shown in Figure 12B. 35 A characteristic X-ray powder diffraction pattern of the crystalline hydrochloride salt of Duloxetine Is shown In Figure 18A and a characteristic X-ray powder diffraction pattern of Memantine hydrochloride is shown in Figure 20A. In addition, the crystalline hydrochloride salt of Duloxetine is also characterized 12 by a typical infrared spectrum as shown in Figure 18B and the crystalline Memantine hydrochloride Is characterized by a typical infrared spectrum as shown in Figure 198. The present invention also relates to a process of the Invention for preparing Citalopram hydrobromide 5 by the general process as defined above. In one embodiment the invention relates to a process for preparing Citalopram hydrobromide which comprises dissolving Citalopram free base in a protic solvent like an alcohol i.e. methanol or Isopropanol and adding 1.0 to about 1.5 equivalents equivalent Trimethylbromosilane. In another embodiment the invention relates to a process for preparing Citalopram hydrobromide which 10 comprises: a) dissolving the free base of Citalopram in an aprotic solvent like ethyl acetate, acetone or acetonitrile, b) adding at least one, and In particular about one, equivalent of a protic solvent like n-butanol or acetic acid, 15 c) treating the solution with at least one, and in particular about one, equivalent of Trimethylbromosilane, d) Isolation of Citalopram hydrobromide. Crytalline Citalopram hydrobromide is obtained. A characteristic X-ray powder diffraction pattern of the crystalline Citaloprarn hydrobromide Is shown in Figure IOA and a typical Infrared spectrum Is shown In Figure 1OB. 20 The present invention also relates to a process of the invention for preparing Aripiprazole hydrochloride Form A, which process preferably comprises: a) dissolving the free base of Aripiprazole in an aprotic solvent, for example methylene dichloride, b) adding at least one, and in particular adding about one, equivalent of a protic solvent like n-butanol 25 or acetic acid, c) treating the solution with at least one equivalent, and in particular adding about one equivalent, of Trimethylchlorosflane, d) Isolation of Aripiprazole hydrochloride Form A. XRPD data of the crystalline product Aripiprazole hydrochloride correspond to X-ray crystallography 30 data Form A as shown in WO 20041083183 (Hetero Drugs Ltd.). Rimonabant can be suspended for example in acetonitrile or dissolved in ethyl acetate and after addition of at least one equivalent of methanol and Trimethylchlorosilane the Hydrochloride of Rimonabant in crystalline form I is obtained. The X-ray powder diffraction pattern of Rimonabant 35 Hydrochloride form I Is shown In Figure 20A. It shows main peaks at 10.4, 14.4, 17.8, 19.2, 20.8, 21.9, 22.2, 26.4, 26.9, 28.7 and 28.5 degrees 2 theta. The infrared spectrum of Rimonabant Hydrochloride form i Is shown In Figure 208. Rimonabant Hydrochloride Form I corresponds to the product prepared 13 according to example 3 of EP 0656354 (Sanofi), in which Rimonabant is dissolved in ether and a saturated solution of HCI gas in ether Is added portIonwise. Clopidogrel Hydrochloride In form I can be obtained for example by adding at least one equivalent of 5 acetic acid and trimethyichlorosilane to a solution of Clopidogret base in ethyl acetate. If acetone or acetonitrile is used as solvent, an anti-solvent like dilsopropyl ether is added in order to precipitate the form I of Clopidogrel Hydrochloride. In one preferred embodiment, Clopidogrel base is dissolved in toluene, one equivalent methanol Is added and the solution is treated with Trimethylchlorosilane. Following the addition of Trimethylchlorosiane, the fluffy precipitate is stirred for a period of time at 10 room temperature to permit conversion to Clopidogrel Hydrochloride form 1. Prasugrel Hydrochloride form B can be obtained for example by adding at least one equivalent of acetic acid and trimethylchlorosilane to a solution of Prasugrel base in acetone. The XRPD pattern of Prasugrel Hydrochloride form B Is shown In Figure 23A and the Infrared spectrum is shown in Figure 15 23B. Characteristic infrared absorption bands are present at 1758 and 1690 cm-1 as reported In US 6693115 in example 3, 4 and 6. The invention further relates to a novel Prasugrel Hydrochloride acetonitrile solvate, which may be characterized by an X-ray powder diffraction pattern comprising peaks at 8.3, 13.8,16.2, 18.8, 23.8. 20 25.4 and 26.8 degrees 2 theta. An example of a X-ray powder diffraction pattern of Prasugrel Hydrochloride acetonitrile solvate is shown in figure 24A. Prasugrel Hydrochloride acetonitrile solvate may be also characterized by a typical Infrared spectrum as shown in figure 24B. Characteristic bands are present at 1760, 1720, 1499, 1210 and 775 cm-1. Prasugrel Hydrochloride acetonltrlle solvate allows an efficient purification step. 25 Prasugrel Hydrochloride acetonitrile solvate can preferably prepared by the a process of the present Invention comprising the steps of' a) dissolving Prasugrel in acetonitrile b) adding at least one equivalent of a protic solvent like acetic acid 30 c) treating the solution with at least one equivalent of Trimethylchlorosilane d) isolation of Prasugrel Hydrochloride acetonitrile solvate. Under air drying conditions. Prasugrel Hydrochloride acetonitrie solvate is stable and does not desolvate. It has an 1 H-NMR spectrum which is substantially Identical to the 1 H-NMR spectrum 35 (DMSO-d6, TMS). Specifically, it has a characteristic peak at 2. ppm (s, 3H) which corresponds to about one mol acetonitrile per mol of substance.

14 Sitagliptin Hydrochloride In amorphous form can be obtained for example by adding at least one equivalent of methanol and trimethylchlorosilane to a solution of Sitagliptin base in a mixture of methylenechloride and diethytether. The XRPD pattern of amorphous Sitagliptin Hydrochloride is shown in Figure 29A and the Infrared spectrum Is shown in Figure 29B. Characteristic infrared 5 absorption bands are present at and cm-1. The present invention also relates to a process for preparing Clopidogrel Hydrobromide form A by the general process as defined above which comprises dissolving Clopidogrel free base in a protic solvent like an alcohol I.e. methanol or Isopropanol and adding 1.0 to about 1.5 equivalents equivalent 10 Trimethylbromosilane. Alternatively, the process for preparing Clopidogrel Hydrobromide form A is a process of the invention which comprises: a) dissolving the free base of Clopidrogel in a non protic solvent like ethyl acetate, b) adding at least one equivalent of a protic solvent like acetic acid. 15 c) treating the solution with at least one equivalent of Trimethylbromosilane, d) isolation of Clopldogrel Hydrobromide form A. A characteristic X-ray powder diffraction pattern of the crystalline Clopidogrel Hydrobromide is shown in Figure 22A and a typical infrared spectrum Is shown In Figure 22B. 20 The present invention further relates to a process of the present invention for preparing Raloxifene Hydrochloride Form A. In a preferred embodiment the process for preparing Raloxifene Hydrochloride Form A comprises a) stirring a suspension of Raloxifene free base in a protic solvent like ethanol b) treating the suspension with Trimethytchorosilane. 25 Alternatively the process for preparing Raloxifene Hydrochloride Form A comprises a) stirring a suspension of an organic salt of Raioxifene like the lactate In a protic solvent like ethanol or In a non protic solvent like methyl isobutyl ketone or acetonitile b) treating the suspension with Trmethylchlorosilane. 30 In methyl isobutyl ketone as solvent typically the reaction with Trimethylchlorosilane is conducted at a temperature of about 100'C, In acetonitrile as solvent, the reaction with Trimethylchlorosilane Is typically conducted at ambient temperature. A characteristic X-ray powder diffraction pattern of Raloxifene Hydrochloride Form A Is shown In Figure 25A and a typical infrared spectrum is shown in Figure 25B 35 The present invention also relates to a novel Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran, which may be characterized by an X-ray powder diffraction pattern comprising peaks at 13.6, 16.6, 17.7, 18.9. 19.2. 19.5, 21.2 and 23.6 degrees 2 theta. An example of an X-ray powder 15 diffraction pattern of Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran is shown in figure 26A. Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran may be also characterized by a typical infrared spectrum as shown In figure 26B. Characteristic bands are present at 1651, 1595, 1226, 1165, 838 and 815 cm-1. Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran allows a more efficient 5 and/or effective purification step for raloxifene production. The invention also relates to a process of the present Invention for the preparation of Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran comprising the steps of: a) stirring a suspension of Raloxifene free base in tetrahydrofuran 10 b) adding 1.0 to about 1.5 equivalents equivalent of a protic solvent like methanol to the suspension of step a) c) treating the suspension of step b) with Trimethylchoroslane. d) isolation of the tetrahydrofuran Hemisolvate of Ratoxifene Hydrochloride. 15 An alternative embodiment of the process for preparing the Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran is a process using an organic salt of Raloxifene which comprises a) stirring a suspension of an organic salt of Raloxifene like the lactate in tetrahydrofuran b) treating the suspension with Trimethylchlorosilane. c) isolation of Raloxifene Hydrochloride Hemisolvate with tetrahydrofuran. 20 Under air drying conditions, Raloxifene Hydrochloride THF Hemisolvate is stable and does not desolvate. It has an 1 H-NMR spectrum which is substantially identical to the 1 H-NMR spectrum (DMSO-d6, TMS). The present invention further relates to a process of the invention for preparing anhydrous Vardenafil 25 Dihydrochlodde, which process comprises: a) dissolving Vardenafil base in an aprotic solvent or for example in a solvent mixture like diethyl ether and methylene dichloride as described in example 10 of EP 1049695 b) adding at least two equivalents of a protic solvent like methanol c) treating the solution with at least two equivalents of Trimethylchlorosilane. 30 d) isolation of anhydrous Vardenafil Dihydrochloride A characteristic X-ray powder diffraction pattern of anhydrous Vardenafil Dihydrochioride is shown in Figure 30A and a typical infrared spectrum Is shown in Figure 30B The present invention further relates to a process of the present invention for preparing Erlotinib 35 Hydrochloride Form A, which process comprises suspending Edotinib base in isopropanol and treating the suspension with at least one equivalent of Trimethyichlorosilane at room temperature. A characteristic X-ray powder diffraction pattern of Erlotinib Hydrochloride Form A is shown In Figure 31A and a typical Infrared spectrum is shown in Figure 31 B. XRPD data of the crystalline product Edotinib 16 Hydrochloride Form A correspond to X-ray crystallography data Form B as shown in US 2004/0162300 (Hofmann-La Roche). By employing the processes of the invention, we have further discovered a Maxifloxacin hydrochloride 5 methylene dichloride solvate characterized by an X-ray powder diffraction pattern with peaks at about 14.6, 18.7, 21.9, 23.5, and 25.3 degrees 2 theta. The Invention therefore also relates to a Moxifloxacin hydrochloride methylene dichloride solvate, In particular wherein the molar ratio of Moxifloxacin hydrochloride to methylene dichloride is about 1:1, in particular this solvate demonstrates peaks in a X ray powder diffraction pattern at about 14.6, 18.7, 21.9, 23.5, and 25.3 degrees 2 theta. A characteristic 10 X-ray powder diffraction pattern of Moxifloxacin hydrochloride methylene dichloride solvate Is shown in figure 13A. Moxifloxacin hydrochloride methylene dichloride solvate for the first time enables preparation of the below-described Moxifloxacin hydrochloride form IV. Moxifloxacin hydrochloride methylene dichloride solvate may be also characterized by characteristic bands in an infrared spectrum at about 2704, 1720, 1434, 1311, 1272, 730 and 702 cm', in particular 15 by the typical infrared spectrum as shown In figure 13B. Moxifloxacin hydrochloride methylene dichlorlde solvate may be prepared by the process of the invention comprising the steps of: a) dissolving Moxifloxacin In methylene dichloride b) adding at least one equivalent, and in particular adding about one equivalent, of a protic solvent, for 20 example n-butanol or acetic acid c) treating the solution with at least one equivalent, and In particular adding about one equivalent, of a trialkyichlorosilane, for example Trimethylchlorosilane d) isolation of Moxifloxacin hydrochloride methylene dichloride solvate. Under air drying conditions, Moxifloxacin hydrochloride methylene dichloride solvate is stable and does 25 not desolvate. TGA of Moxifloxacin hydrochloride methylene dichloride solvate shows a loss of mass of 16% between 80 and 180C, which corresponds to one mol dichloromethane per mol of substance. The invention therefore relates to Moxifloxacin hydrochloride methylene dichloride solvate showing a loss of mass of between 10% and 20%, and in particular about 16%, between 80 and 1 80*C, which corresponds to about one moi dichloromethane per mol of substance. 30 Moxifloxacin hydrochloride methylene dichloride solvate has an 'H-NMR spectrum which is substantially identical to the 'H-NMR spectrum (DMSO-d6, TMS) shown in Figure 13C. Specifically, it has a characteristic peak at 5.77 ppm (s, 2H) which corresponds to about one mol methylene dichloride per mol of substance. 35 By employing the processes of the invention, we have further discovered a Moxifloxacin hydrochloride nitromethane solvate. The Invention therefore also relates to such a solvate, in particular wherein the molar ratio of Moxifloxacin hydrochloride to nitromethane is about 1:1. The solvate can be further characterized by an X-ray powder diffraction pattern with peaks at about 11.2, 14.7, 16.9, 20.4. 22.0, 17 22.6 and 23.4 degrees 2 theta, in particular by the characteristic X-ray powder diffraction pattern of Moxifloxacin hydrochloride nitromethane solvate as shown in figure 16A. Moxifioxacin hydrochloride nitromethane solvate may also be characterized by characteristic bands In an infrared spectrum at about 2879, 1715, 1550, 1310 and 1032 cm'', in particular by the typical Infrared spectrum as shown In 5 figure 168. Moxifloxacin hydrochloride nitromethane solvate alows a more efficient and/or effective purification step for moxifioxacin production. Moxifloxacin hydrochloride nitromethane solvate may be prepared by the process of the Invention, in particular comprising the steps of: a) dissolving Moxifloxacin in nitromethane 10 b) adding at least one equivalent, and In particular adding about one equivalent, of a protic solvent like n-butanol or acetic acid c) treating the solution with at least one equivalent, and in particular adding about one equivalent, of Trimethylchlorosilane d) isolation of Moxifloxacin hydrochloride nitromethane solvate. 15 Moxfloxacin hydrochloride nitromethane solvate has an 'H-NMR spectrum which is substantially Identical to the 'H-NMR spectrum (DMSO-d8, TMS) shown in Figure 16D. Specifically, it has a characteristic peak at 4.4 ppm (s, 3H) which corresponds to about one moi nitromethane per mol of substance. 20 The present invention also relates to a novel anhydrous hydrochloride salt of Moxifloxacin, herein called form IV. In particular, form IV does not convert to a hydrous form of Moxifloxacin hydrochloride. when placed in a dessicator at a humidity level of 33% for 48 hours. More particular, the Invention relates to form IV characterized by an X-ray powder diffraction pattern with peaks at about 10.0, 13.2. 15.3, 17.2 and 24.4 degrees 2 theta. A characteristic X-ray powder diffraction pattern of the anhydrous 25 form IV of Moxifioxacln hydrochloride is shown in figure 14A. The Invention also relates to form IV characterized by Infrared absorption bands at about 2704, 1720, 1434, 1312 and 1273 cm 4. Moxifloxacin hydrochloride form IV may further be characterized by showing a typical infrared spectrum as shown in figure 146. The new anhydrous form IV may preferably be prepared by desolvating Moxifioxacin hydrochloride 30 methylene dichlorlde solvate by drying in vacuum at about 100"C. The anhydrous form IV shows a lower hygroscopicity as anhydrous form 11 described in US 5849 752 (Bayer) and a lower hygroscopicity than anhydrous form B described In Cheml Spa's patent application WO 20051054240, facilitating its handling and/or storage. After placing Moxifloxacin hydrochloride anhydrous form IV in a dessicator at a humidity level of 33% for 48 hours anhydrous form IV does not convert to a hydrous 35 form of Moxifloxacin hydrochloride. This Is demonstrated by the XRPD pattern which shows no alteration and by the moisture content which rises only from 0.5% to 0.6%. The invention also relates to pharmaceutical compositions comprising form IV.

18 By employing the processes of the Invention, we have further discovered a Moxifloxacin hydrochloride acetic acid solvate. The invention therefore also relates to such a solvate, in particular wherein the molar ratio of Moxifloxacin hydrochloride to acetic acid is about 1:1. This solvate may be further characterized by an X-ray powder diffraction pattern with peaks at about 5.3. 7.6, 9.3, 15.2, 16.2. 18.8. 5 20.8, 26.6 and 27.7 degrees 2 theta. In a preferred embodiment the moxifloxacin hydrochloride acetic acid solvate shows a X-ray powder diffraction pattern substantially in accordance with the one shown in figure 15A. Moxifioxacin hydrochloride acetic acid solvate may also be characterized by a typical infrared spectrum as shown In figure 15B. Exemplary infrared absorption bands of Moxifloxacin hydrochloride acetic acid solvate can be observed at 2707. 2289, 1736, 1421, 1308, 1246, 917 and 10 757 cn-. Moxifloxacin hydrochloride acetic acid solvate shows good solubility and/or stability. Moxifloxacin hydrochloride acetic acid solvate may be prepared by the process as defined and described above. which comprises: a) dissolving Moxifloxacin in acetic acid or in a mixture of acetic acid and an organic solvent like acetone or acetonitrile 15 b) adding Trimethylchlorosilane c) Isolation of Moxifioxacin hydrochloride acetic acid solvate. Moxifloxacin hydrochloride acetic acid solvate has an 'H-NMR spectrum which is substantially identical to the 'H-NMR spectrum (DMSO-d6, TMS) shown in Figure 15C. Specifically, it has a characteristic peak at 1.9 ppm (s. 3H) which corresponds to about one mol acetic acid per mol of substance. The 20 .invention also relates to pharmaceutical compositions comprising the Moxifloxacin hydrochloride acetic acid solvate of the invention. The present invention also relates to a process of the invention for preparing Linezolid hydrochloride, which preferably comprises adding a protic solvent like n-butanol or acetic acid to a solution of 25 Linezolid in an organic solvent like acetone or acetonitrile and treating the mixture with Trimethylchlorosilane. The present Invention also relates to crystalline Unezolid hydrochloride. Unezolid hydrochloride may be characterized by, for example, characteristic peaks In the XRPD pattern at values of about 13.9, 18.2. 19.1, 23.0 and 27.2 degrees two theta. A characteristic X-ray powder diffraction pattern of the 30 crystalline Unezolid hydrochloride Is shown in Figure 19A and a typical infrared spectrum Is shown in Figure 19B . As shown in figure 19A. Unezolid hydrochloride shows characteristic peaks In the XRPD pattern at values of about 13.9, 18.2. 19.1, 23.0 and 27.2 degrees two theta. Surprisingly, this hydrochloride has been found to be stable, something which could not have been predicted based on the chemical structure of Linezolid. Unezolid hydrochloride will allow the production of pharmaceutical 35 compositions. As explained above, the Invention allows fine-tuning of the amount of hydrohalogenic acid generated in the crystallization solution, of the speed with which said hydrohalogenic acid is generated - for 19 example by controlling the rate of addition of the trialkytsflylhalogenide - and of the conditions, under which the hydrohalogenic acid is generated - for example by adjusting temperature. solvent composition or further parameters as necessary for obtaining a desired salt (e.g. the mono- or dihydrohalide salt) of the organic amine or a desired polymorphic form of the hydrohatide salt of the 5 organic amine. Thus, the present invention relates to the use of a trialkylsilylhalogenide for the preparation of a crystalline hydrohalide of an organic amine. This use is particularly advatageous if the crystalline hydrohalide of the organic amine is.one desired hydrohalide among several known hydrohalides of said organic amine, for example in such cases where a crystalline monohydrochloride of a drug is desired, while there is or are also di- or tr-hydrochloride of said drug. Using the 10 conventional technique of adding HCI gas to the crystallization mixture would not be difficult to control with regard to amount of HCI added, would not allow the same flexibility with regard to the choice of crystallization conditions and would simply be more difficult to handle. A further advantage is that the hydrohalogenic acid can be generated essentially in the absence of water or at least in the presence of only small amounts of water. Thus, anhydrous forms of crystalline 15 hydrohalides of organic amines become accessible. Thus, the invention also relates to the use of a trialkylhalogenide in the preparation of an anhydrous crystalline hydrohalide salt of an organic amine. Furthermore, the generation of controlled amounts of hydrohalogenic acid essentially in the absence of water makes solvates of organic amines accessible which would not form in the presence of water, for example solvates which are thermodynamically less stable than the corresponding hydrates. Thus, the 20 present Invention also relates to the use of a trialkylhalogenide in the preparation of solvates of crystalline hydrohalides of an organic amine, in particular the preparation of anhydrous solvates. It will be apparent to the skilled person that preferred trialkayisilyhalogenides. preferred organic amines and preferred conditions for these Uses are as defined above in the description of the process of the Invention. 25 The following examples will illustrate, but do not limit the scope of the present invention. Wherever used, room temperature denotes a temperature in the range of 20 - 30*C. EXAMPLES 30 The infrared spectra were recorded using a BRUKER Tensor 27 FTIR-spectrometer with diamond ATR-cell.. The XRPD were recorded on a AXS-BRUKER X-ray powder diffractometer D-8 using the following acquisition conditions: tube anode: Cu; generator tension: 40 kV; generator current 40 mA; start angle: 2.0* ?; end angle: 40.0* ?; step size: 0.01* ?; time per step: 2 seconds. 35 Differential scanning calorimetry (DSC) was performed with a DSC 7 (Perkin-Elmer, Norwalk, Ct., USA) using the Pyris 2.0 software. Samples were weighed into 25 pl Al-Pans. Dry nitrogen is used as the purge gas (purge: 20 ml min 1 ). I 1-NMR spectra were recorded on a Brucker AM-300 spectrometer.

20 Example 1 preparation of the Mycophenolate Mofetil hydrochloride In its crystalline anhydrous form 5 2 g (4,61 mmol) mycophenolate mofetil base were dissolved-In 50 mi ethyl acetate at room temperature. To this solution 0,3ml (1,2 equiv.) acetic acid and 0,7ml (1.2 equiv.) trimethylchlorosilane were added under stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 1 hour and the precipitate filtered off. The solid was washed with ethyl acetate and dried under vacuum at room temperature to yield 2,11 g (97,6%) of mycophenolate mofetil 10 hydrochloride. mp. = 157.2*C The XRD pattern of mycophenolate mofetil hydrochloride is shown in Figure 1A and corresponds to crystalline anhydrous form with X-ray crystallography data as shown In WO 95107902. The Infrared spectrum obtained is shown In Figure 1B. 15 DSC of mycophenolate mofetil hydrochloride shows an endotherm peak at about 159*C (onset temperature about 155'C, see Figure 1 C). Example 2 preparation of Venlafaxine hydrochloride 20 Example 2.a preparation of Venlafaxine hydrochloride form I 0,4 g (1,44 mmol) Venlafaxine base were dissolved in 10 mi ethyl acetate at room temperature. To this solution 0,1 ml (1,1 equiv.) acetic acid and 0,2m (1,1 equiv.) trimethylchlorosilane were added under 25 stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 30 minutes and the precipitate filtered off. The solid was washed with ethyl acetate and dried under vacuum at room temperature to yield 0,41g (89,1%) of Venlafaxine hydrochloride. mp. = 208*C The XRD patten of Venlafaxine hydrochloride form I is shown In Figure 2A and corresponds to form I 30 with X-ray crystallography data as shown in US 0310114536. The Infrared spectrum obtained Is shown in Figure 2B. Example 2.b preparation of Venlafaxine hydrochloride form If 35 0,4 g (1,44 mmol) Venlafaxine base were dissolved in 10 ml acetone at room temperature. To this solution 0,1ml (1,1 equiv.) acetic acid and 0,2ml (1,1 equiv.) trimethyichlorosilane were added under stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 21 30 minutes and the precipitate was filtered off. The solid was washed with ethyl acetate and dried under vacuum at room temperature to yield 0.38g (82,6%) of Venlafaxine hydrochloride form II. The XRD pattern of Venlafaxine hydrochloride form 11 is shown in Figure 3A and corresponds to form 11 with X-ray crystallography data as shown in WO 02/45658. 5 The Infrared spectrum obtained is shown in Figure 3B. Example 2.c preparation of Venlafaxine hydrochloride form Ii 0.4 g (1,44 mmot) Venlafaxine base were dissolved in 10 ml acetonitrile at room temperature. To this 10 solution 0.1ml (1,1equiv.) acetic acid and 0.2ml (1.1equiv.) trimethylchlorosilane were added under stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 30 minutes and the precipitate was filtered off. The solid was washed with ethyl acetate and dried under vacuum at room temperature to yield 0,23g (51,1%) of Venlafaxine hydrochloride form 1I. 15 Example 3 preparation of Sertraline hydrochloride form II using Sertraline base Example 3.a 3 g (9,8 mmol) Sertraline base were dissolved in 60 ml acetonitrile at room temperature. To this 20 solution 0,6ml (1eq) acetic acid and 1,4ml (1,1eq) of trimethylchlorosilane was added under stirring. While adding Sertraline hydrochloride precipitated nicely in the crystalline Form ii. After stirring the suspension for one hour the product was filtered of and dried at 50*C for 3 hours to yield 3,2g (95.3%) of Sertrallne hydrochloride Form Il. mp.: 252*C 25 The XRD pattern obtained is shown In Figure 4A and corresponds to pure form 11. The infrared spectrum obtained Is shown in Figure 46. Example 3.b 3 g (9.8 mmol) Sertraline base were dissolved In a mixture of 60 ml acetonitrile and I ml n-butanol. 30 The solution was heated to 50'C and 1,4 ml (1,1 eq) trimethylchlorosilane was added under stirring. Immediately during the addition Sertraline hydrochloride precipitated in the crystalline Form II. After stirring for 30 min at 50'C, the suspension was cooled to room temperature and stirred for about one hour. The product was filtered off and dried at 50'C for 3 hours to yield 3.1g (94%) of Sertraline hydrochloride form II. 35 Example 3.c 10 g (32,7 mmol) Sertraline base in 200 ml methyl Isobutyl ketone (MIBK) were heated to about 80"C. To the solution 2,4 ml (1,1eq) acetic acid and then 4,5 ml (1,1eq) trimethylchlorosilane were added 22 under stirring. A gelatinous mass was first obtained which becomes crystalline after stirring at 80'C for one hour. The reaction mixture was cooled to room temperature and again stirred for about one and a half hour. The product was filtered off and dried at 50'C for 4 hours to yield 10.93 g (97.7%) of Sertraline hydrochloride form II. 5 Example 4 preparation of Sertraline hydrochloride form 11 using Sertraline Mandelate Example 4.a 10 A suspension of 3 g (6.5 mmol) Sertraline Mandelate salt in 60 ml acetonitrile was stirred at room temperature and 1,4 ml (1,7eq) trimethylchlorosiane was added. The viscous suspension changed first to a thin suspension and afterwards a thick suspension of crystals of Sertrallne hydrochloride Form 11 within 15 minutes was obtained. After stirring for about one hour, the product was filtered off and dried at 50*C under vacuum to yield 2,09 g (96,3%) of Sertraline hydrochloride form 1l. 15 Example 4.b A suspension of 3 g (6,5 mmol) Sertraline Mandelate salt in 60 ml methyl ethyl ketone was heated to about 80*C and 0.9 ml (1,1 eq) trimethylchlorosilane was added. A clear solution was obtained and soon after Sertraline hydrochloride in the crystalline form 11 starts to precipitate. The reaction mixture 20 was cooled to room temperature under stirring within one hour and then the product was filtered off and dried at 50*C under vacuum to yield 1,97 g (87,8%) of Sertraline hydrochloride form 11. Example 4.c A suspension of 3 g (6,5 mmol) Sertraline Mandelate salt in 60 ml methyl Isobutyl ketone was heated 25 to about 80*C and 0,9 ml (1,1 eq) trimethylchlorosllane is added. The suspension changed to a gelateneous mass. After approximately 5 minutes Sertraline hydrochloride in the crystalline form 11 started to form. The reaction mixture was stirred at 80'C for about 20 minutes and then cooled to room temperature under stirring within one hour. The product was filtered off and dried at 50*C under vacuum for 3 hours to yield 2,11 g (94,0%) of Sertraline hydrochloride form II. 30 Example 4.d A suspension of 15 g (32,7 mmol) Sertraline Mandelate salt in 300 ml methyl isobutyl ketone was heated to about 10C and 4.6 ml (1,1 eq) trimethylchlorosilane was added. The suspension changed to a gelateneous mass. After approximately 5 minutes Sertraline hydrochloride in the crystalline form Il 35 started to form The suspension changed to a gelateneous mass. After approximately 5 minutes. The reaction mixture was stirred at 10C for about 15 minutes and then cooled to room temperature under stirring within one and a half hour. The product was filtered off, washed twice with 10 ml acetone 23 and dried at 50"C under vacuum for 4 hours to yield 10,64 g (94,9%) of Sertraline hydrochloride form II. Example 5 5 preparation of Sertraline hydrochloride form 11 using Sertraline Oxalate Example 5.a preparation of Sertraline Oxalate To a solution of 3 g (9,8 mmol) Sertraline free base in 50 ml ethyl acetate was added a solution of 0,97 10 g (1,1 eq) oxalic acid In 50 ml methanol. After stirring for 15 minutes the crystalline precipitate was filtered off and dried at 50*C under vacuum to yield 3.37 g (86,8%) of Sertraline Oxalate. Example 5.b preparation of Sertraline hydrochloride form |1 from Sertraline oxalate 15 A suspension of 0,7 g (1.77 mmol) Sertraline Oxalate In 15 ml acetonitrile was stirred at room temperature and 250 pi (1.1 eq) trimethylchlorosilane was added. After addition the suspension converted almost to a solution but at the same time Sertraline hydrochloride In the crystalline form Il started to precipitate. After stirring for about one hour, the product was filtered off and dried at 50*C under vacuum to yield 0,47 g (77,8%) of Sertrallne hydrochloride form 11. 20 Example 6 preparation of Sertraline hydrochloride form I. A solution of 3 g (9,8 mmol) Sertraline base in 60 ml 2-propanol was stirred at room temperature and 0,6 ml acetic acid and 1,4 ml (1.1 eq) trimethylchlorosilane were added under stirring. After 2 minutes 25 at room temperature the crystallization started. The suspension was stirred for 60 minutes and the precipitate filtered off. The solid was washed with 2-propanol and dried under vacuum at 50'C for 3 hours to yield 2,95g (87,8%) of Sertraline hydrochloride form I. The XRD patten obtained Is shown in Figure 5A and corresponds to form 1. The Infrared spectrum obtained is shown in Figure 5B. 30 Example 7 preparation of Donepezil hydrochloride Example 7.a 35 preparation of Donepezl hydrochloride form II 0,5 g (1,32 mmol) Donepezil base were dissolved In 30 ml ethyl acetate at room temperature. To this solution 0,1ml (1,1 eq) acetic acid and 0,2ml (1.1 eq) trimethylchlorosilane were added under stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 2 hours 24 and the precipitate was filtered off. The solid was washed with ethyl acetate and dried under vacuum at room temperature to yield 0,55g (100%) of Donepezil hydrochloride form 1I. The XRD pattern obtained is shown in Figure 6A and corresponds to form II. The infrared spectrum obtained is shown in Figure 6B. 5 Example 7.b preparation of Donepezil hydrochloride form Ill 0.5 g (1.32 mmol) Donepezil base were dissolved In 10 ml acetone at room temperature. To this 10 solution 0,1ml (1,1 eq) acetic acid and 0,2ml (1,1 eq) trimethyichlorosilane were added under stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 30 minutes and the precipitate filtered off. The solid was washed with ethyl acetate and dried under vacuum at room temperature to yield 0,54g (98,5%) of Donepezil hydrochloride. mp.=211'C 15 The XRD pattern obtained is shown in Figure 7A and corresponds to form Ill. The infrared spectrum obtained is shown in Figure 7B. Example 7.c preparation of Donepezil hydrochloride form Ill 20 Example 7.b was repeated by using aetonitrile instead of acetone. Yield: 0,47g (85,6%) of donepezil hydrochloride form 111. Example 8 25 preparation of Terbinafine hydrochloride Example 8.a 0,4 g (1,37 mmol) Terbinafine base were dissolved in 5 ml acetone at room temperature. To this solution 86 pl (1.1 eq) acetic acid and 191 p1(1,1 eq) trimethyichlorosilane were added under stirring. 30 After 2 minutes at room temperature the crystallization started. The suspension was stirred for 1 h and the precipitate was filtered off. The solid was washed with acetone and dried under vacuum at room temperature to yield 0,3g (66.7%) of Terbinafine hydrochloride. mp.= 185*C The XRD pattern of Terbinafine hydrochloride Is shown In Figure 8A and corresponds to literature data 35 (Cryst. Eng. Comm., 2002, 4(67), 393-400). The Infrared spectrum obtained is shown in Figure 8B. Example 8.b Example 8.a was repeated by using acetonitrile instead of acetone.

25 Yield: 0,1 9g (42,2%) of Terbinafine hydrochloride Example 8.c Example 8.a was repeated by using tert.-butyl-methyl-ether instead of acetone. 5 Yield: 0,419 (91,1%) of Terbinafine hydrochloride Example 9 preparation of Cinacalcet hydrochloride 10 Example 9.a 1,0 g (2,80 mmol) Cinacalcet base were dissolved in 10 ml acetonitile at room temperature. To this solution 0,19 ml (1.2 eq) acetic acid and 0,42 ml (1,2 eq) trimethylchlorosilane were added under stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 2h and the precipitate was filtered off. The solid was washed with acetonitrile and dried under vacuum 15 at room temperature to yield 0,45g (40,8%) of Cinacalcet hydrochloride. mp. = 173C The XRD pattern obtained is shown In Figure 9A and the infrared spectrum obtained is shown In Figure 9B. 20 Example 9.b Example 9.a was repeated by using ethylacetate instead of acetonitrile. Yield: 0,41g (37,2%) of Cinacalcet hydrochloride. Example 10 25 preparation of Citalopran hydrobromide Example 10.a 0,72 g (22,2 mmol) Citalopram base were dissolved in 10 ml acetonitrile at room temperature. To this solution 0,14 ml (1,1 eq) acetic acid and 0,32 ml (1,1 eq) trimethylbromosilane were added under 30 stirring. After 30 minutes at room temperature 15 ml of diethylether were added and the crystallization started. The suspension was stirred for I h and the precipitate filtered off. The solid was washed with acetonitrile and dried under vacuum at room temperature to yield 0,67g (74,5%) of Citalopran hydrobromide. mp.= 182*C 35 The XRD pattern obtained is shown In Figure 1 OA and the infrared spectrum obtained Is shown in Figure 1OB. Example 10.b 26 Example 10.a was repeated with 0,5 g (15.4 mmol) Citalopram base using ethylacetate instead of acetonitrile as solvent. Yield: 0,53g (84,8%) of Citalopram hydrobromide. 5 Example 1O.c Example 10.a was repeated with 0,59 g (18,2 mmol) Citalopram base using acetone instead of acetonitrile as solvenL Yield: 0,67g (90,9%) of Citalopran hydrobromide. 10 Example 10.d 0.27 g (0,8 mmol) Citalopram base were dissolved In 3 ml Isopropanol at room temperature and 145 pl (1,1 eq) trimethylbromosflane were added to the solution. After standing in a refrigerator over night the crystalline precipitate was filtered off and dried in vacuum to yield 0.25g (74,1%) of Citalopram hydrobromide. 15 Example 11 preparation of Ariplprazole hydrochloride Form A 2,0 g (4,46 mmol) aripiprazole were dissolved In 20 ml 1,2-dichloromethane at room temperature. To this solution 0,45ml (1,1 eq) n-butanol and 0,63 ml (1,1 eq) trimethytchlorosilane were added under 20 stirring. After 2 minutes at room temperature the crystallization started. The suspension was stirred for 15 minutes and the precipitate was filtered off. The solid was washed with 1,2-dichloromethane and dried under vacuum at room temperature to yield 2,05g (94.0%) of aripiprazole hydrochloride. mp.= 210*C The XRD pattern of the product is shown in Figure 1 1A and corresponds to XRPD data of Aripiprazole 25 hydrochloride Form A as shown in WO 2004/083183 (Hetero Drugs Ltd.). The infrared spectrum obtained is shown in Figure 11 B. Example 12 preparation of Pramipexole Monohydrochloride 30 0,5 g (2,37 mmol) Pramipexole base were dissolved in 20 ml acetonitrile at room temperature. To this solution 0,24 ml n-butanol (2,6 mmol, 1,1 equiv.) and 0,33 ml trimethylchlorosflane (2,6 mmol, 1,1 equiv.) were added under stirring. After 1 minute at room temperature the crystallization started. The suspension was stirred for 1 hour and the precipitate was filtered off. The solid was washed with acetonitrile and dried under vacuum at room temperature to yield 0,56g (95.5%) of Pramipexole 35 Monohydrochlorlde. mp.= 264'C The XRD pattern obtained Is shown In Figure 12A and the Infrared spectrum obtained is shown in Figure 12B.

27 Example 13 preparation of Moxifloxacine hydrochloride anhydrous form IV 5 Examplel3.a Moxifloxacine hydrochloride methylene dichloride solvate 5 g (12,5 mmol) Moxifloxacin were prepared according to EP 550903 and dissolved In 50 ml methylene dichloride at room temperature. To this solution 0,9 ml (1,2 equiv.) acetic acid and 2 ml (1.2 equiv.) trimethylchlorosilane were added under stirring. Immediately after addition of the chlorosilane the 10 crystallization started. The suspension was stirred for about 30 min and the precipitate filtered off and dried under vacuum at room temperature to yield 6,3g (94,2%) of the 1:1 solvate of Moxifloxacine hydrochloride with methylene dichloride. 1 H-NMR (DMSO-d6): 0.8 - 0.95 (m, IH), 0.95 - 1.3 (m, 3H), 1.6 - 1.9 (m, 4 H). 2.55 - 2.75 (m, 1H), 2.8 - 3.0 (m. 1 H), 3.5 - 3.7 (m with Singlet at 3.6 ppm, 4H), 3.7 - 3.8 (m, I H), 3.8 - 4.0 (m, 2H), 4.0 15 4.2 (m, 2H). 5.77 (s. 2H). 7.65 (d. J = 14 Hz, 1H), 8.66 (s, 1H), 8.95 (s, broad, 1H), 10.2 (s, broad, 1H), 15.1 (s, broad, 1H). The singlet at 5.77 ppm corresponds to about one mol methylene dichlorlde per mol of substance (see Figure 13C). The XRD pattern of the product Is shown In Figure 13A and the Infrared spectrum obtained is shown 20 In Figure 13B. The Moxifloxacine hydrochloride solvate with methylene dichloride Is not hygroscopic (no water uptake after I day at 33% relative humidity. Example 13.b 25 Moxifloxaclne hydrochloride anhydrous form IV 2 g Moxilioxacine hydrochloride methylene dichloride solvate were dried in vacuum at 100*C for about 6 hours yielding 1,75 g of the desolvated anhydrous form IV of Moxifloxacine hydrochloride. The XRD pattern of the product is shown in Figure 14A and the infrared spectrum obtained is shown 30 in Figure 148. Example 14 preparation of Moxifoxacine hydrochloride solvate with ecetic acid 35 Example 14.a 3,0 g (7,47 mmol) moxifloxacin were prepared according to EP 550903 and dissolved In 30 ml acetic acid at room temperature. To this solution 2,0 ml (2.1 eq) trimethylchlorosilane were added under stirring. 30 minutes after addition of the chlorosilane the crystaflization started. The suspension was 28 stirred for about 3,5 hours and the precipitate filtered off washed with acetonitrile and dried under vacuum at room temperature to yield 3.21g (86.3%) of the 1:1 solvate of Moxifloxaclne hydrochloride with acetic acid. H-NMR (DMSO-d6): 0.8 -0.95 (m, 1 H), 0.95 - 1.3 (m, 3H), 1.6 -1.9 (m, 4 H), 1.9 (s. 3H). 2.55 - 2.75 5 (m, 1H), 2.8 - 3.0 (m, I H), 3.1 - 3.25 (m. 1 H), 3.5 - 3.7 (m with Singlet at 3.6 ppm. 4H), 3.7 - 3.8 (m. IH), 3.8 - 4.0 (m, 2H), 4.0 - 4.2 (m, 2H), 7.63 (d, J = 14 Hz, 1 H), 8.65 (s, 1H), 9.1 (s. broad, 1H), 10.4 (s, broad, 1H), 12.7 (s, broad, 1H). The singlet at 1.9 ppm corresponds to about one mol acetic acid per mol of substance (see Figure 15C). 10 The XRD pattern of the product Is shown In Figure 15A and the Infrared spectrum obtained is shown in Figure 15B. Example 14.b 1.0 g (2,49 mmol) Moxifloxacin were prepared according to EP 550903 and dissolved in 5 ml acetic 15 acid and 5 ml acetonitrile at room temperature. To this solution 0,38 ml (1,2 eq) trimethylchlorosilane were added under stirring. 2 hours after addition of the chlorosilane the crystallization didn't start. To this solution 0.38 ml trimethylchlorosilane were once more added under stirring. The suspension was stored for about 17 hours at 4*C and the precipitate filtered off washed with acetonitrile and dried under vacuum at room 20 temperature to yield 0,93g (75,0%) of the 1:1 solvate of Moxifloxacine hydrochloride with acetic acid. Example 15 preparation of Moxifloxacine hydrochloride solvate with nitromethane 0,5 g (1,25 mmol) Moxifloxacin were prepared according to EP 550903 and dissolved in 15 ml 25 nitromethane at appr. 60'C. To this solution 0.14 ml (2 eq) acetic acid and (2 eq) ml trimethyichlorosilane were added under stirring. The suspension was stored for about 17 hours and the precipitate was filtered off, washed with acetone and dried under vacuum at room temperature to yield 0,55g (88.2%) of the 1:1 solvate of Moxifloxacine hydrochloride with nitromethane. 1 H-NMR (DMSO-d6): 0.8 - 0.95 (m, IH), 0.95 -1.3 (m, 3H), 1.6 -1.9 (m, 4 H), 2.55 - 2.75 (m,I 1H), 30 2.8 - 3.0 (m, 1 H). 3.1 - 3.25 (m, 1 H), 3.5 - 3.7 (m with Singlet at 3.6 ppm, 4H). 3.7 - 3.8 (m, i H), 3.8 3.95 (m. 2H), 4.0 - 4.2 (m, 2H), 4.44 (s, 3H), 7.63 (d, J = 14 Hz, IH), 8.65 (s, IH), 9.0 (s, broad, IH), 10.3 (s. broad, IH). 15.1 (s, broad, IH). The singlet at 4.44 ppm corresponds to about one moi nitromethane per mol of substance (see Figure 16C). 35 The XRD patten of the product Is shown in Figure 16A and the Infrared spectrum obtained Is shown in Figure 16B. Example 16 29 preparation of Duloxetine hydrochloride Example 16.a 0.3 g (1,0 mmol) Duloxetine base were dissolved in 5 ml ethylacetate at room temperature. To this 5 solution 65 pi acetic acid and 0,14 ml trimethytchlorosilane were added under stirring. After addition of the chlorosilane a precipitate was formed and the suspension was stirred for about 2 hours at room temperature. The white crystalline solid was filtered off and dried under vacuum at room temperature to yield 0,21g (62,9%) of Duloxetine hydrochloride mp.= 161*C 10 The XRD pattern of the product Is shown in Figure 17A and the infrared spectrum obtained is shown in Figure 17B. Example 16.b Example 16.a was repeated by using acetone instead of ethylacetate. 15 Yield: 0,26g (77,9%) of Duloxedine hydrochloride. Example 17 preparation of Linezolid hydrochloride 20 Example 17.a 5 g (14,8 mmol) Unezolide were dissolved in 200 ml acetonitrile at room temperature. To this solution 1,0 ml (1,1equiv.) acetic acid and 2,1 ml (1,1equiv.) trimethylchlorosilane were added under stirring. After addition of the chlorosilane and stirring for 1 hour a precipitate was formed and the suspension was stirred for about 3.5 hours at room temperature. The white crystalline solid was filtered off and 25 dried under vacuum at room temperature to yield 1,43g (25,8%) of linezolide hydrochloride. mp.= 163*C The XRD pattern of the product is shown in Figure 18A and the infrared spectrum obtained is shown in Figure 18B. 30 Example 17.b Example 17.a was repeated with 0,5 g (1,5 mmol) Unezolid using acetone Instead of acetonitrile as solvent. Yield: 0,20g (36,4%) of Unezolide hydrochloride. 35 Example 18 preparation of Memantine hydrochloride 30 0,5 g (2,8 mmol) Memantine base were dissolved in 10 ml ethylacetate at room temperature. To this solution 0,1 ml (1,1 equiv.) methanol and 0.4 ml (1,1 equiv.) trimethylchlorosilane were added under stirring. After addition of the chlorosilane a precipitate was formed and the suspension was stirred for about 2 hours at room temperature. The white crystalline solid was filtered off and dried under vacuum 5 at room temperature to yield 0,59g (98,0%) of the Memantine hydrochloride. mp.= 293-296'C The XRD pattern of the product is shown in Figure 19A and the infrared spectrum obtained is shown in Figure 19B. 10 Example 19 Preparation of Rimonabant hydrochloride form I Example 19a 1 g (2,16 mmol) Rimonabant was suspended in 20 ml acetonitrile at room temperature. To the 15 suspension 0.105 ml (1,2 equiv.) methanol and 0,33 ml (1,2 equiv.) trimethylchlorosilane were added under stirring. A clear solution was obtained and soon after Rimonabant hydrochloride In the crystalline form I started to precipitate. The product was filtered off and dried at room temperature under vacuum over night to yield 0,9 g (83,4%) of Rimonabant hydrochloride form 1. The XRD pattern of the product Is shown in Figure 20A and the infrared spectrum obtained is shown In 20 Figure 20B. Example 19b 1 g (2,16 mmol) Rimonabant was dissolved In 10 ml ethyl acetate at room temperature To this solution 0,105 ml (1.2 equiv.) methanol and 0,33 ml (1,2 equiv.) trimethytchlorosilane 25 were added under stirring. After addition of the chlorosilane a precipitate was formed and the white crystalline solid was filtered off and dried under vacuum at room temperature to yield 0,95g (88.1%) of Rimonabant hydrochloride form 1. Example 19c 30 Example 19b was repeated using acetone instead of ethyl acetate as solvent. Yield: 0,89g (82,5%) of Rimonabant hydrochloride form I. Example 20 Preparation of Clopidogrel hydrochloride form I 35 Example 20a 1,2 9 (3,73 mmol) Clopidogrel were dissolved in 10 ml acetone at room temperature. To the solution 255 pl (1.2 equiv.) acetic acid and 565 pi (1,2 equiv.) trimethylchlorosilane 31 were added under stirring. After addition of 6 ml dilsopropylether Clopidogrel hydrochloride started to precipitate. After stirring for one hour the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 0,85 g (63,8%) Clopidogrel hydrochloride form 1. The XRD pattern of the product is shown in Figure 21A and the infrared spectrum obtained is shown in 5 Figure 21B Example 20b I g (3,11 mmol) Clopidogrel was dissolved In 10 ml acetonitrile at room temperature. To the solution 213 pl (1,2 equiv.) acetic acid and 475 pl (1.2 equiv.) trimethylchlorosilane 10 were added under stirring. The mixture was cooled down to about 5*C and 40 ml diisopropylether was added under stirring. After stirring for one hour the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 0,50 g (45,0%) Clopidogrel hydrochloride form I. Example 20c 15 1 g (3,11 mmol) Clopidogrel was dissolved in 10 ml ethyl acetate at room temperature. To the solution 213 pl (1,2 equiv.) acetic acid and 475 pl (1,2 equiv.) trimethylchlorosgane were bdded under stirring. After addition of the chlorosilane a viscous solid precipitated which converted to a crystalline product within about 5 min. The mixture was stirred at room temperature for one hour. The product was then filtered off and dried at room temperature under vacuum over night to 20 yield 0,88 g (79,3%) Clopidogrel hydrochloride form 1. Example 20d 30 g (93,22 mmol) Clopidogrel free base were dissolved In 1000 ml toluene in a 1 Uter reaction flask equipped with a mechanical stirrer and a dropping funnel. To the solution was added 4.5 ml (1.2 25 equiv.) methanol and after mbdng by stirring 14,1 ml (1,2 equiv.) trimethylchlorosilane was added dropwise at room temperature under slowly stirring within 45 min. After addition the reaction mixture was stirred at room temperature for about three hours wherein the fluffy precipitate converted to a white crystalline solid. The salt was filtered off and washed with 20 ml toluene The product was dried under vacuum at room temperature over night yielding 29,1 g (87,1 %) Clopidogrel hydrochloride form 30 1. Example 21 Preparation of Clopidogrel hydrobromide form A 35 Example 21a I g (3,11 mmol) Clopidogrel was dissolved in 10 ml ethyl acetate at room temperature. To the solution 213 pl (1,2 equiv.) acetic acid and 482 pl (1.2 equiv.) trlmethylbromosllane 32 were added under stirring. After addition of the bromosilane a viscous solid precipitated which converted to a crystalline product within about 30 min. The mixture was stirred at room temperature for one hour. The product was then filtered off and dried at room temperature under vacuum over night to yield 1.03 g (82,3%) Clopidogrel hydrobromide form A. 5 The XRD pattern of the product is shown in Figure 22A and the infrared spectrum obtained is shown In Figure 22B Example 21b 1 g (3,11 mmol) Clopidogrel was dissolved in 10 ml isopropanol. To the solution 482 pl (1, 2 equiv.) 10 trimethylbromosilane were added. After stirring for 90 min the product crystallized after scratching with a glass stick. The hydrobromide salt was filtered off and dried at room temperature under vacuum over night to yield 0.86 g (68.7%) Clopidogrel hydrobromide form A. 15 Example 22 Preparation of Prasugrel Hydrochloride Form B 5,0 g (13,4 mmol) Prasugrel base were dissolved in 75 ml acetone at room temperature. To the solution 919 pl (1.2 equiv.) acetic acid and 2053 pi (1.2 equiv.) trimethylchlorosilane 20 were added under stirring. Immediately after addition a white precipitate was obtained. The hydrochloride salt wals filtered off and dried at room temperature under vacuum for 6 hours to yield 4,41 g (80,4%) Prasugrel hydrochloride form B. The XRD patten of the product is shown In Figure 23A and the infrared spectrum obtained Is shown in Figure 23B 25 Example 23 Preparation of Prasugrel Hydrochloride acetonitrile solvate 0.5 g ( 1,34 mmol) Prasugrel base were dissolved in 7,5 ml acetonitrile. The unsolved part was filtered off. To the solution 82 pl (1,2 equiv.) acetic acid and 205 pl ( 1,2 equiv.) trimethylchlorosilane were 30 added under stirring. The mixture was stirred at room temperature for seventeen hours. The suspension was filtered off and dried at room temperature under vacuum over night to yield 0,43 g (78%) Prasugrel Hydrochloride acetonitrile solvate. 'H-NMR (DMSO-d6): 0.84 - 0.97 (m. 2H), 0.98 - 1.16 (m, 2H), 1.87 - 2.0 (m, 1 H), 2.08 (s, 2H), 2.29 (s, 3 H), 2.96 - 3.15 (m. 2H), 3.34 - 3.6 (m, 1H), 3.7 - 4.2 (m, 3H), 6.14 (s, broad, 1H), 6.58 (s, 1H). 35 7.3 - 7.55 (m, 2H), 7.55 - 7.8 (m, 2H). The singlet at 2.08 ppm corresponds to about one mol acetonitrile per one and a half mol of substance. The XRD pattern of the product Is shown In Figure 24A and the infrared spectrum Is shown In Figure 248 33 Example 24 Preparation of Raloxifene Hydrochloride form A 5 Example 24a 1,0 g (1,77 mmol) Raloxifene lactate was suspended In 10 ml acetonitrile at room temperature. To the suspension 272 pi (1,2 equiv.) trimethylchlorosilane were added under stirring. After stirring for one hour the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 0,80 g (82,5%) Raloxifene Hydrochloride form A. 10 The XRD pattern of the product Is shown In Figure 25A and the infrared spectrum obtained Is shown In Figure 25B Example 24b 1,5 g (2,66 mmol) Raloxifene lactate were suspended In 30 ml methyl isobutyl ketone (MIBK) at room 15 temperature. The suspension was heated to 100'C. To the suspension 408 il (1,2 equiv.) trimethyichlorosilane were added under stirring. The suspension was cooled down to room temperature. After stirring for one hour the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 1,42 g (97,6%) Raloxifene Hydrochloride form A. 20 Example 24c 0,51 g (0.90 mmol) Raloxifene base were suspended in 5 ml ethanole at room temperature. To the suspension 162 pl (1,2 equiv.) trimethylchlorosilane were added under stirring. A dear solution was obtained and soon after Raloxifene hydrochloride in the crystalline form started to precipitate. After stirring for three hours the crystalline precipitate was filtered off and dried at room temperature under 25 vacuum over night to yield 0,41 g (74,6%) Raloxifene Hydrochloride form A. Example 25 Preparation of Raloxifene hydrochloride THF hemisolvate Example 25a 30 0,50 g (0,88 mmol) Raloxifene base were suspended in 5 mi tetrahydrofuran at room temperature. To the suspension 51 pi (1,2 equiv.) methanol and 162 pl (1,2 equiv.) trimethyichlorosilane were added under stirring. After stirring for three hours at room temperature the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 0,45 g (97,6%) Raloxlfene Hydrochloride THF hemisolvate. 35 'H-NMR (DMSO-de): 1.25 - 1.4 (m, I H), 1.6 - 1.9 (m, 7H), 2.8 - 3.1 (m, 2H), 3.3 - 3.55 (m, 4H). 3.55 - 3.65 (m, 2.6 H), 4.4 (t, broad, 2H), 6.7 - 6.8 (m, 2H), 6.9 (dd. J = 2.26 and 8.8 Hz, 1H), 6.98 (d, J = 9 Hz, IH), 7.15 -7.22 (m, 2H), 7.3 (d, J =8.7 Hz, IH), 7.4 (d, J =2.3 Hz, IH), 7.71 (d, J 9 Hz, 1H), 9.95 (d, J = 9 Hz, 1H), 10.8 (s, brad, 1H).

34 The amount of tetrahydrofuran present In the crystalline material wals about 0,6 molar equivalents as determined by proton NMR spectroscopy. The XRD pattern of the product is shown in Figure 26A and the infrared spectrum obtained is shown In Figure 26B. 5 Example 25b 0,30g (0,53 mmol) Raloxifene lactate were suspended in 3 ml tetrahydrofuran at room temperature. To the suspension 82 pl (1.2 equiv.) trimethylchlorosilane were added under stirring. After stirring for two hours at room temperature the crystalline precipitate was filtered off and dried at room temperature 10 under vacuum over night to yield 0,28 g (102,6%) Raloxifene Hydrochloride THF hemisolvate. Example 26 Preparation of Olanzapine Dihydrochloride 15 Example 26a 1,0 g (3,20 mmol) Olanzapine base were suspended in 10 ml acetonitrile at room temperature. To the suspension 312 pl (2,4 equiv.) methanol 980 pl (2,4 equiv.) trimethylchlorosilane were added under stirring. After stirring for one hour the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 1,24 g (100,54%) Olanzapine Dihydrochloride form 1. 20 The XRD pattern of the product is shown in Figure 27A and the infrared spectrum obtained is shown in Figure 27B Example 26b 1.0 g (3,20 mmol) Olanzapine base were suspended in 10 ml acetone at room temperature. To the 25 suspension 312 pl (24 equiv.) methanol 980 pI (2,4 equiv.) trimethylchlorosilane were added under stirring. After stirring for one hour the crystalline precipitate was filtered off and dried at room temperature under vacuum over night to yield 1.35 g (107,31%) Olanzapine dihydrochloride form 1. Example 27 30 Preparation of Darifenacin Hydrobromide 0,9 9 (2,11 mmol) Darifenacin base were dissolved in 9 ml methyl ethyl ketone at room temperature. To the solution 103 p (1,2 equiv.) methanol 329 pi (1,2 equiv.) trimethyibromosilane were added under stirring. After stirring for one hour the crystalline precipitate was filtered off and dried at room 35 temperature under vacuum over night to yield 0,88 mg (82,13%) Darifenacin Hydrobromide. The XRD pattern of the product is shown in Figure 28A and the infrared spectrum obtained Is shown In Figure 286 35 Example 28 Preparation of anhydrous Sitagliptin Hydrochloride In amorphous form 0,085 g (0,21 Mmol) Sitagliptin base were dissolved In 2 ml Diethylether and 3 ml Methylenchloride at 5 room temperature. To the solution 10 pl (1,2 equiv.) methanole and 32 pi (1,2 equiv.) trimethylchlorosilane were added under stirring. Immediately after addition a precipitate was obtained. The suspension was stirred for 1 hour, filtered off and dried at room temperature under vacuum over night to yield 0,089 g (96,8%) Sitagliptin Hydrochloride in amorphous form. The XRD patten of the product is shown In Figure 29A and the infrared spectrum obtained is shown In 10 Figure 29B Example 29 Preparation of anhydrous Vardenafil Dihydrochlorde 15 0,2g (0,359 mmol) Vardenafil base were suspended in 4 ml diethylether at room temperature. To the suspension 5 ml methylene dichlorde were added and a solution was obtained. 35p (2,4 equiv.) methanol and 110 pl (2,4 equiv.) trimethylchlorosilane were added to the solution and immediately after addition a white precipitate was obtained. The suspension was stirred for twenty minutes , filtered off and dried at room temperature under vacuum over night to yield 0.2g (95,4%) 20 Vardenafil Dihydrochloride. The XRD pattern of the product Is shown in Figure 30A and the infrared spectrum obtained is shown in Figure 30B Example 30 25 Preparation of Edotinib Hydrochloride Form A 0,3g ( 0.82 mmol) Ertotinob base were suspended In 3 ml Isopropanol. 126plI (1,2eq.) trimethylchlorosilane are added to the suspension. A white precipitate was obtained. After stirring for 1 hour, the precipitate was filtered off and dried at room temperature under vacuum over night to yield 30 0,26g (80,8%) Edotinib Hydrochloride Form A. The XRD pattern of the product is shown in Figure 31 A and the infrared spectrum obtained is shown In Figure 31B - 35A Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. 5 The reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of endeavour to which this [0 specification relates.

Claims (55)

1. Process for the preparation of a crystalline hydrohalide of an organic amine wherein a trialkylsilylhalogenide is added to the organic amine in a solvent, which organic amine is in the form 5 of the free base or an acid addition salt, wherein, when the organic amine is in the form of an acid addition salt, the conjugated acid of the acid addition salt is weaker than the hydrohalogenic acid.

2. The process according to claim 1, which process comprises the steps of: (a) dissolving or suspending the organic amine in a protic solvent; 10 (b) adding the trialkylsilyl halogenide; (c) allowing crystals to form and; (d) collecting the crystals formed.

3. The process of claim 2 wherein In step (a) the protic solvent is a compound comprising a hydroxyl 15 group or a carboxyl group, in particular wherein the protic solvent is an aromatic or aliphatic alcohol, a silanol, a ketone capable of enolization, or an aromatic or aliphatic carbonic acid, more particularly wherein the protic solvent Is an C1-C6 alkyl alcohol, formic acid or acetic acid.

4. The process of claims 2 or 3 wherein in step (b) the trialkylsilyl halogenide is trimethylsilyl chloride, 20 trimethylsflyl bromide or trimethylsilyl iodide, in particular trimethylsilylchloride.

5. The process of claIm 1, which process comprises the steps: (a) dissolving or suspending the organic amine in an aprotic solvent; (b) adding at least one equivalent of a protic solvent; 25 (c) adding the trialkylsilyl halogenide; (d) allowing crystals to form; and (e) collecting the crystals formed.

6. The process of claim 5 wherein in step (b) the protic solvent is a compound comprising a hydroxyl 30 group or a carboxyl group, in particular wherein the protic solvent is an aromatic or aliphatic alcohol, a silanol a ketone capable of enolization or an aromatic or aliphatic carbonic acid, more particularly wherein the protic solvent is an C1-C6 alkyl alcohol, formic acid or acetic acid.

7. The process of claims 5 or 6 wherein in step (c) the trialkylsilyl halogenide is trimethylsilyl chloride, 35 trimethylsilyl bromide or trimethylsilyl iodide, in particular trimethylsilylchloride.

8. The process of claim 1, which process comprises the steps: (a) dissolving, suspending or generating the acid addition salt of the organic amine in a solvent; 37 . (b) adding the trialkylsilyl halogenide; (c) allowing crystals to form; and . (d) collecting the crystals formed. 5

9. The process of claim 8 wherein in step (a) the acid addition salt of the organic amine is generated in situ by adding an acid, which conjugated acid Is weaker than hydrochloric acid and preferably Is an organic acid, to a solution or slurry of the amine.

10. The process of claims 8 to 9 wherein In step (a) the organic acid Is selected from substituted or 10 unsubstituted alkanoic acids, aromatic carboxylic acids, dicarboxylic acids or citric acid.

11. The process of daim 10, wherein the organic acid is acetic acid.

12. The process of any one of claims 1 to 10, wherein the organic amine Is a pharmaceutically active 15 compound, in particular a drug for humans.

13. The process of claim 12 wherein the drug comprises a primary, secondary, tertiary or quaternary amino group, In particular wherein the drug is selected from the group consisting of an antidepressant - in particular the serotonin reuptake Inhibitor Sertraline. Duloxetine, Venlafaxine or 20 Cltalopram, a nootropic agent, In particular Donepezil, an antipsychotic agent, in particular the neuroleptic Aripiprazole, a muscle relaxant, In particular the antispasmodic agent Memantine, an immunosuppressant, in particular Mycophenolate Mofetil, an antifungal, in particular Terbinafine, an antibacterial, In particular a Quinolone as for example Moxifloxacin or the oxazolidinone Linezolid, a calcimimetic agent, In particular Cinacalcet, a Dopamine agonist, In particular the D2-receptor agonist 25 Pramipexole, an antiobesity agent, In particular Rimonabant, an antithrombotic, in particular Clopidogrel and Prasugrel, an antiosteoporotic, In particular Raloxifene, an antispasmodic, In particular Darifenacin, an agent for treatment of male erectile dysfunction, in particular Vardenafil, an antidiabetic, in particular the DPP-IV inhibitor Sitagliptin, and an antineoplastic, in particular Erlotinib. 30

14. The process according to clalm 9 for making Mycophenolate Mofetil hydrochloride in its crystalline . anhydrous form, in particular wherein In step (a) Mycophenolaet Mofetil Is dissolved In ethyl acetate, acetonitrile or acetone and acetic acid is used as organic acid and in step (b) Trimethylsilyl chloride is used. 35

15. The process according to claim 9 for making Venlafaxine hydrochloride Form I, in particular wherein In step (a) Venlafaxine is dissolved In ethyl acetate and acetic acid is used as organic acid and In step (b) Trimethylsilyl chloride Is used. 38

16. The process according to claim 9 for making Venlafaxine hydrochloride Form II, in particular wherein In step (a) Venlafaxine is dissolved in acetone or acetontrile and acetic acid is used as organic acid and In step (b)Trimethylsilyl chloride Is used. 5

17. The process according to claim 9 for making Sertraline hydrochloride Form I, in particular wherein in step (a) sertraline Is dissolved in acetonitrile and acetic acid is used as organic acid and in step (b) Tdmethylsilyl chloride is used.

18. The process according to claim 9 for making Sertraline hydrochloride Form lI, in particular wherein 10 in step (a) Sertraline Is dissolved in methyl isobutyl ketone and acetic acid Is used as organic acid and in step (b) Trimethylsilyl chloride is used.

19. The process according to claim 5 for making Sertraline hydrochloride Form 1I, in particular wherein sertraline is dissolved In acetonitrile and wherein In step (b) n-butanol and in step (c) Trimethylsilyl 15 chloride is used.

20. The process according to claim 8 for making Sertrallne hydrochloride Form 1I. In particular wherein In step (a) a suspension of Sertraline Mandelate In acetonitrile is used and in step (b) Trimethysilyl chloride is used. 20

21. The process according to claim 8 for making Sertrafline hydrochloride Form il, in particular wherein In step (a) a solution of Sertraline Mandelate in methyl ethyl ketone or in methyl isobutyl ketone is used and in step (b) Trimethylsilyl chloride is used. 25

22. The process according to claim 8 for making Sertraline hydrochloride Form 1I. In particular wherein in step (a) a suspension of Sertraline Oxalate In acetonitrile is used and In step (b) Trmethylsilyl chloride is used.

23. The process according to claim 9 for making Donepezil hydrochloride Form Ill, In particular wherein 30 In step (a) Donepezil Is dissolved in acetone or acetonitrile and acetic acid Is used as organic acid and In step (b) Trimethylsilyl chloride is used.

24. The process according to claim 9 for making Terbinafine hydrochloride, In particular wherein in step (a) Terbinafine is dissolved In acetone or acetonitrile and acetic acid Is used as organic acid 35 and In step (b) Trimethylsilyl chloride Is used. 39

25. The process according to claim 9 for making Cinacalcet hydrochloride, in particular wherein In step (a) Cinacalcet is dissolved in acetone or acetonitrile and acetic acid is used as organic acid and in step (b) Trimethylsilyl chloride is used. 5

26. The process according to claim 9 for making a Moxifoxacin hydrochloride methylene dichioride solvate, In particular wherein in step (a) Moxifloxacin is dissolved in methylene dichloride and acetic acid is used as organic acid and in step (b) Trimethysilyl chloride Is used.

27. The process according to claim 9 for making a Moxifloxacin hydrochloride nitromethane solvate, In 10 particular wherein in step (a) Moxifloxacin is dissolved in nitromethane and acetic acid is used as organic acid and in step (b) Trimethylsilyl chloride is used.

28. The process according to claim 2 for making Moxifloxacin hydrochloride acetic acid solvate. In particular wherein in step (a) Moxifioxacin is dissolved in acetic acid and in step (b) Trimethylsilyl 15 chloride is used.

29. The process according to claim 9 for making Moxifloxacin hydrochloride acetic acid solvate, in particular wherein in step (a) Moxifloxacin is dissolved in acetone or acetonitrile and acetic acid is used as organic acid and in step (b) Trimethylsilyl chloride is used 20

30. The process according to claim 2 for making Citalopram hydrobromide, in particular wherein In step (a) Citalopram is dissolved in isopropanol and in step (b) Trimethylsilyl bromide Is used.

31. The process according to claim 9 for making Citalopram hydrobromide, in particular wherein In step 25 (a) Citalopram is dissolved in ethyl acetate, acetone or acetonitrile and acetic acid Is used as organic acid and in step (c) Trimethylsilyl bromide is used.

32. The process according to claim 5 for making Aripiprazole hydrochloride, in particular wherein Aripiprazole -is dissolved in methylene dichloride and wherein in step b) n-butanol and in step c) 30 Trimethylchlorosilane Is used.

33. The process according to claim 5 for making Pramipexole Monohydrochloride, in particular wherein Pramipexole is dissolved in acetonitrile and wherein in step b) n-butanol and In step c) Trimethyichlorosilane Is used. 35

34. The process according to claim 9 for making Duloxetine hydrochloride, In particular wherein In step (a) Duloxetine is dissolved in ethyl acetate or acetone and acetic acid is used as organic acid and in step (c) Trimethylsilyl chloride is used. 40

35. The process according to claim 9 for making Unezolid hydrochloride, in particular wherein in step (a) Linezolid is dissolved in ethyl acetate or acetone and acetic acid is used as organic acid and in step (c) Trimethylsiyl chloride is used. 5

36. The process according to claim 5 for making Memantine hydrochloride, in particular wherein in step (a) Memantine is dissolved in ethyl acetate and wherein in step (b) methanol and in step (c) Trimethylsilyl chloride is used. 10

37. Use of a trialkyiylhalogenide for the preparation of a crystalline hydrohalide of an organic amine.

38. Use according to claim 37, wherein the crystalline hydrohalide of an organic amine is one desired hydrohalide among several existing hydrohalides of said organic amine. 15

39. Use according to claims 37 or 38 for the preparation of an anhydrous crystalline hydrohalide of an organic amine.

40. Use according to claims 37 to 39 for the preparation of a solvate of a crystalline hydrohalide of an organic amine. 20

41. The process according to claim 5 for making Rimonabant Hydrochloride form I wherein in step (a) Rimonabant is dissolved in ethyl acetate or acetone or is suspended in acetonitrile and wherein in step (b) methanol and in step (c) Trimethylsilyl chloride is used. 25

42. The process according to claim 5 for making Clopidrogel Hydrochloride form I wherein in step (a) Clopidrogel is dissolved In ethyl acetate, acetone, acetonitrile or toluene and wherein in step (b) methanol or acetic acid and in step (c) Trimethylsilyl chloride Is used.

43. The process according to claim 5 for making Clopidrogel Hydrobromide form A wherein in step (a) 30 Clopidrogel is dissolved In ethyl acetate and wherein in step (b) acetic acid and In step (c) Trimethylsilyl bromide is used.

44. The process according to claim 2 for making Clopidrogel Hydrobromide form A wherein in step (a) Clopidrogel is dissolved in isopropanol and in step (b) Trimethylsilyl bromide is used.' 35

45. The process according to claim 5 for making Prasugrel Hydrochloride form A wherein in step (a) Prasugrel is dissolved in acetone and wherein in step (b) acetic acid and in step (c) Trimethylsilyl chloride is used. 41

46. The process according to claim 5 for making Prasugrel Hydrochloride acetonitril solvate wherein in step (a) Prasugrel is dissolved In acetonitrile and in step b) acetic acid Is used and In step (c) Trimethylsilyl chloride is used. 5

47. The process according to claim 2 for making Raloxifene Hydrochloride form A wherein in step (a) Raloxifene is suspended in ethanol and in step (b) Trimethylsilyl chloride is used.

48. The process according to claim 8 for making Raloxifene Hydrochloride form A wherein In step (a) a 10 suspension of Raloxifene lactate In acetonitrile or methyl isobutyl ketone is used and In step b) Trimethylsilyl chloride is used.

49. The process according to claim 5 for making Raloxifene Hydrochloride tetrahydrofuran Hemisolvate wherein in step (a) Raloxifene is suspended in tetrahydrofuran, in step b) methanol Is used and in 15 step (c) Trimethylsiyl chloride is used.

50. The process according to claim 8 for making Raloxifene Hydrochloride tetrahydrofuran Hemisolvate wherein in step (a) a suspension of Raloxifene lactate in tetrahydrofuran Is used and in step b) Trimethylsilyl chloride is used. 20

51. The process according to claim 5 for making Olanzapine Dlydrochloride form I wherein In step (a) Olanzapine is suspended In acetone or acetonitrile and wherein in step b) methanol is used and in step (c) at least two equivalents of Trimethysilyl chloride are used. 25

52. The process according to claim 5 for making Darifenacin Hydrobromide wherein in step (a) Darifenacin is dissolved In methyl ethyl ketone and wherein in step (b) methanol and In step (c) Trimethylsilyl bromide is used.

53. The process according to claim 5 for making Sitagliptin Hydrochloride in amorphous form wherein 30 In step (a) Sitagliptin is dissolved In a mixture of diethylether and methylene dichloride and wherein In step (b) methanol and in step (c) Trimethylslyl chloride is used.

54. The process according to claim 5 for making Vardenafil Dihydrochioride wherein in step (a) Vardenafil is suspended in a mixture of diethylether and methylene dichloride and wherein in step 35 (b) methanol and in step (c) at least two equivalents of Trimethylsilyl chloride are used.

55. The process according to claim 2 for making Erlotinib Hydrochloride form A wherein In step (a) Erlotinib is suspended in isopropanol and in step (b) Trimethylslyl chloride is used.