AU2003265853A1 - Hedgehog antagonists, methods and uses related thereto - Google Patents

Hedgehog antagonists, methods and uses related thereto

Info

Publication number
AU2003265853A1
AU2003265853A1 AU2003265853A AU2003265853A AU2003265853A1 AU 2003265853 A1 AU2003265853 A1 AU 2003265853A1 AU 2003265853 A AU2003265853 A AU 2003265853A AU 2003265853 A AU2003265853 A AU 2003265853A AU 2003265853 A1 AU2003265853 A1 AU 2003265853A1
Authority
AU
Australia
Prior art keywords
methods
hedgehog antagonists
uses related
hedgehog
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003265853A
Other versions
AU2003265853A8 (en
Inventor
Henryk K. Dudek
Irina Karavanov
Karen Kotkow
Carmen Pepicelli
Lee Rubin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of AU2003265853A8 publication Critical patent/AU2003265853A8/en
Publication of AU2003265853A1 publication Critical patent/AU2003265853A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2003265853A 2002-08-29 2003-08-29 Hedgehog antagonists, methods and uses related thereto Abandoned AU2003265853A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40714502P 2002-08-29 2002-08-29
US60/407,145 2002-08-29
PCT/US2003/027279 WO2004020599A2 (en) 2002-08-29 2003-08-29 Hedgehog antagonists, methods and uses related thereto

Publications (2)

Publication Number Publication Date
AU2003265853A8 AU2003265853A8 (en) 2004-03-19
AU2003265853A1 true AU2003265853A1 (en) 2004-03-19

Family

ID=31978427

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003265853A Abandoned AU2003265853A1 (en) 2002-08-29 2003-08-29 Hedgehog antagonists, methods and uses related thereto

Country Status (2)

Country Link
AU (1) AU2003265853A1 (en)
WO (1) WO2004020599A2 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US7709454B2 (en) * 1997-06-20 2010-05-04 New York University Methods and compositions for inhibiting tumorigenesis
US7741298B2 (en) * 1997-06-20 2010-06-22 New York University Method and compositions for inhibiting tumorigenesis
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
DK1730280T3 (en) 2004-03-26 2019-02-04 Curis Inc RNA interference modulators for hedgehog signaling and applications thereof
JPWO2006101273A1 (en) * 2005-03-25 2008-09-04 武田薬品工業株式会社 Cancer preventive / therapeutic agent
AU2006332945C1 (en) 2005-12-23 2013-02-28 Wyeth Modified lysine-mimetic compounds
EP2074087A2 (en) 2006-12-21 2009-07-01 Wyeth Synthesis of pyrrolidine compounds
TWI433674B (en) 2006-12-28 2014-04-11 Infinity Discovery Inc Cyclopamine analogs
AU2008345097A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
GEP20125664B (en) 2008-02-26 2012-10-10 Takeda Pharmaceuticals Co Condensed heterocyclic derivatives and application thereof
US20110217294A1 (en) * 2008-04-11 2011-09-08 Daniel Fults Combination of hgf inhibitor and hedgehog inhibitor to treat cancer
BRPI0911618A2 (en) 2008-04-29 2019-09-24 Lilly Co Eli disrupted phthalazine hedgehog pathway antagonists.
EA018931B1 (en) 2008-11-03 2013-11-29 Эли Лилли Энд Компани Disubstituted phthalazine hedgehog pathway antagonists
KR101335770B1 (en) 2008-11-17 2013-12-12 일라이 릴리 앤드 캄파니 Tetrasubstituted pyridazines hedgehog pathway antagonists
CN102216285B (en) 2008-11-17 2014-08-13 伊莱利利公司 Tetrasubstituted pyridazine hedgehog pathway antagonists
AR077014A1 (en) 2009-06-19 2011-07-27 Lilly Co Eli COMPOUND DERIVED FROM FTALAZINE 1,4-DISPOSED, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND USE TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER
CA2769795C (en) 2009-08-05 2020-01-07 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
US8614208B2 (en) 2009-08-26 2013-12-24 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
WO2011024869A1 (en) 2009-08-26 2011-03-03 武田薬品工業株式会社 Fused heterocyclic ring derivative and use thereof
JP5599802B2 (en) 2009-08-26 2014-10-01 武田薬品工業株式会社 Fused heterocyclic derivatives and uses thereof
US8927718B2 (en) 2009-08-26 2015-01-06 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
ES2593256T3 (en) 2010-05-21 2016-12-07 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulations
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
WO2012064973A2 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN103648499B (en) 2011-01-10 2017-02-15 无限药品股份有限公司 Processes for preparing isoquinolinones and solid forms of isoquinolinones
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
EP2734520B1 (en) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2013032591A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
US9630979B2 (en) 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
ES2691742T5 (en) 2012-11-01 2022-03-18 Infinity Pharmaceuticals Inc Treatment of Cancers Using Modulators of PI3 Kinase Isoforms
AU2013352256A1 (en) 2012-11-29 2015-06-18 Strasspharma, Llc Methods of modulating follicle stimulating hormone activity
JP6806562B2 (en) 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Regulator of the eIF2α pathway
NZ629037A (en) 2013-03-15 2017-04-28 Infinity Pharmaceuticals Inc Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9192609B2 (en) 2013-04-17 2015-11-24 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
US20160113932A1 (en) 2013-05-30 2016-04-28 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
CA2925944C (en) 2013-10-04 2023-01-10 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN104906113A (en) * 2014-03-12 2015-09-16 淄博赛维医药技术有限公司 Antitumor medicine
EP4066834A1 (en) 2014-03-19 2022-10-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2017015681A (en) 2015-06-04 2018-09-11 Pellepharm Inc Topical formulations for delivery of hedgehog inhibitor compounds and use thereof.
WO2017139497A1 (en) 2016-02-11 2017-08-17 PellePharm, Inc. Hedgehog inhibitor for use in relief of and treatment of pruritus or itching
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017223422A1 (en) 2016-06-24 2017-12-28 Infinity Pharmaceuticals, Inc. Combination therapies
DK3618847T3 (en) 2017-05-05 2021-05-25 Boston Medical Ct Corp GAP junction modulators of intercellular communication and their use in the treatment of diabetic eye disease

Also Published As

Publication number Publication date
WO2004020599A2 (en) 2004-03-11
AU2003265853A8 (en) 2004-03-19
WO2004020599A3 (en) 2006-12-28

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase