AU2003232173A1 - Compounds and methods for controlling bacterial virulence - Google Patents

Compounds and methods for controlling bacterial virulence

Info

Publication number
AU2003232173A1
AU2003232173A1 AU2003232173A AU2003232173A AU2003232173A1 AU 2003232173 A1 AU2003232173 A1 AU 2003232173A1 AU 2003232173 A AU2003232173 A AU 2003232173A AU 2003232173 A AU2003232173 A AU 2003232173A AU 2003232173 A1 AU2003232173 A1 AU 2003232173A1
Authority
AU
Australia
Prior art keywords
compounds
methods
bacterial virulence
controlling bacterial
virulence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003232173A
Inventor
Michael Givskov
John Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QSI PHARMA AS
Original Assignee
QSI PHARMA AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QSI PHARMA AS filed Critical QSI PHARMA AS
Publication of AU2003232173A1 publication Critical patent/AU2003232173A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003232173A 2002-06-12 2003-06-12 Compounds and methods for controlling bacterial virulence Abandoned AU2003232173A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38757502P 2002-06-12 2002-06-12
US60/387,575 2002-06-12
PCT/DK2003/000388 WO2003106445A1 (en) 2002-06-12 2003-06-12 Compounds and methods for controlling bacterial virulence

Publications (1)

Publication Number Publication Date
AU2003232173A1 true AU2003232173A1 (en) 2003-12-31

Family

ID=29736332

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003232173A Abandoned AU2003232173A1 (en) 2002-06-12 2003-06-12 Compounds and methods for controlling bacterial virulence

Country Status (2)

Country Link
AU (1) AU2003232173A1 (en)
WO (1) WO2003106445A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2596480A1 (en) 2005-02-04 2006-08-10 Wisconsin Alumni Research Foundation Compounds and methods for modulating communication and virulence in quorum sensing bacteria
KR100841333B1 (en) * 2006-11-22 2008-06-25 재단법인서울대학교산학협력재단 Antibacterial homoserine lactone derivatives and method of removing bacteria using the same
KR100841289B1 (en) * 2006-11-30 2008-06-25 재단법인서울대학교산학협력재단 Antibacterial homoserine lactone derivatives and method of preventing a biofilm formation
US7910622B2 (en) 2007-03-19 2011-03-22 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
UA108738C2 (en) * 2009-04-03 2015-06-10 METHOD OF PREPARATION OF CYTOCHROME INVENTOR P450 MONOOXYGENASES AND INTERMEDIATED INTERMEDIATES
US8624063B2 (en) 2009-06-30 2014-01-07 Wisconsin Alumni Research Foundation Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
US20140294922A1 (en) * 2010-12-22 2014-10-02 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Compound with antibacterial activity
JP2015510509A (en) 2012-02-03 2015-04-09 ギリアード サイエンシーズ， インコーポレイテッド Methods and intermediates for preparing pharmaceuticals
CN103073516B (en) * 2013-01-05 2014-08-13 中国科学院化学研究所 Derivative containing halogen light active oxazolidinone and preparation method thereof
JP6282290B2 (en) * 2013-01-31 2018-02-21 プロメラス， エルエルシー Norbornenyl hydrocarbylene dihydrocarbylborane and process for producing the same
CN105130970B (en) * 2014-05-30 2019-06-25 中国人民解放军军事医学科学院毒物药物研究所 N- sulfonyl homoserine lactone analog derivative, preparation method and use
CN106146432B (en) * 2015-03-23 2018-12-21 兰州大学 A kind of acylated homoserine lactone class compound and its environmentally friendly application
US11247976B2 (en) 2016-04-29 2022-02-15 Wisconsin Alumni Research Foundation Synthetic ligands that modulate the activity of the RhlR quorum sensing receptor
US10526278B2 (en) 2017-10-19 2020-01-07 Wisconsin Alumni Research Foundation Inhibitors of quorum sensing receptor LasR

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE565852A (en) * 1957-03-20
GB2012170B (en) * 1977-12-24 1982-09-02 Fisons Ltd Pesticidal and platn growth regulant compounds and composiions
US5591872A (en) * 1993-08-09 1997-01-07 The University Of Iowa Research Foundation Autoinducer molecule
AUPN191295A0 (en) * 1995-03-23 1995-04-27 Unisearch Limited Microbiocide or microbial regulator
US5731315A (en) * 1995-06-07 1998-03-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted sulfonic acid n- (aminoiminomethyl)phenylalkyl!-azaheterocyclamide compounds
HUP9904188A3 (en) * 1996-12-13 2003-02-28 Aventis Pharmaceuticals Inc Co Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
GB9725599D0 (en) * 1997-12-04 1998-02-04 Univ Nottingham Control of biofilm formation
AUPR575401A0 (en) * 2001-06-18 2001-07-12 Unisearch Limited Method of causing sloughing
US20040197341A1 (en) * 2001-09-03 2004-10-07 Jean-Claude Pechere Therapeutic process for p. aeruginosa infections using macrolide antibiotics
SE0103710D0 (en) * 2001-11-07 2001-11-07 Astrazeneca Ab Compounds

Also Published As

Publication number Publication date
WO2003106445A1 (en) 2003-12-24

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase