AU2003224341A1 - Inhibitors of checkpoint kinases (wee1 and chk1) - Google Patents

Inhibitors of checkpoint kinases (wee1 and chk1)

Info

Publication number
AU2003224341A1
AU2003224341A1 AU2003224341A AU2003224341A AU2003224341A1 AU 2003224341 A1 AU2003224341 A1 AU 2003224341A1 AU 2003224341 A AU2003224341 A AU 2003224341A AU 2003224341 A AU2003224341 A AU 2003224341A AU 2003224341 A1 AU2003224341 A1 AU 2003224341A1
Authority
AU
Australia
Prior art keywords
wee1
chk1
inhibitors
checkpoint kinases
checkpoint
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003224341A
Inventor
Richard John Booth
William Alexander Denny
Ellen Myra Dobrusin
Alan John Kraker
Ho Huat Lee
Florence Oliver Joseph Mccarthy
Lorna Helen Mitchell
Brian Desmond Palmer
Jeffrey Bruce Smaill
Andrew Mark Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of AU2003224341A1 publication Critical patent/AU2003224341A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
AU2003224341A 2002-04-26 2003-04-15 Inhibitors of checkpoint kinases (wee1 and chk1) Abandoned AU2003224341A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37580602P 2002-04-26 2002-04-26
US60/375,806 2002-04-26
PCT/IB2003/001417 WO2003091255A1 (en) 2002-04-26 2003-04-15 Inhibitors of checkpoint kinases (wee1 and chk1)

Publications (1)

Publication Number Publication Date
AU2003224341A1 true AU2003224341A1 (en) 2003-11-10

Family

ID=29270703

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003224341A Abandoned AU2003224341A1 (en) 2002-04-26 2003-04-15 Inhibitors of checkpoint kinases (wee1 and chk1)

Country Status (7)

Country Link
EP (1) EP1501831A1 (en)
JP (1) JP2006504632A (en)
AU (1) AU2003224341A1 (en)
BR (1) BR0309783A (en)
CA (1) CA2483496A1 (en)
MX (1) MXPA04010617A (en)
WO (1) WO2003091255A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1869020T1 (en) 2005-03-29 2011-02-28 Icos Corp Heteroaryl urea derivatives useful for inhibiting chk1
PE20080695A1 (en) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd DIHYDROPIRAZOLOPYRIMIDINONE DERIVATIVES AS KINASE WEEL INHIBITORS
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2155752B1 (en) * 2007-04-25 2018-09-19 Merck Sharp & Dohme Corp. Polymorph of dihydropyrazolopyrimidinone derivative as weel kinase.inhibitor
JPWO2009054332A1 (en) 2007-10-23 2011-03-03 萬有製薬株式会社 Pyridone-substituted dihydropyrazolopyrimidinone derivatives
JP2012051804A (en) * 2008-12-26 2012-03-15 Kyoto Univ Eg5 INHIBITOR
AU2010218781A1 (en) * 2009-02-25 2011-07-28 Msd K.K. Pyrimidopyrimidoindazole derivative
SI2477628T1 (en) 2009-09-15 2014-11-28 Merck Sharp & Dohme Corp. Preparation of crystalline hemihydrate forms of dihydropyrazolopyrimidinone
EP2673250B1 (en) * 2011-01-28 2016-11-23 University of Kentucky Research Foundation Stilbene analogs and methods of treating cancer
JP6569908B2 (en) * 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 Anticancer composition
TW201702218A (en) 2014-12-12 2017-01-16 美國杰克森實驗室 Compositions and methods relating to the treatment of cancer, autoimmune disease, and neurodegenerative disease
US11479555B2 (en) 2018-02-23 2022-10-25 Newave Pharmaceutical Inc. Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
CN110872296B (en) * 2018-08-31 2023-05-23 上海弘翊生物科技有限公司 dihydro-isoindole-1H-pyrazolo [3,4-d ] pyrimidinone compound, and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3833008A1 (en) * 1988-09-29 1990-04-05 Goedecke Ag PYRROLOCARBOZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
GB2239013B (en) * 1989-11-01 1993-06-02 Toyama Chemical Co Ltd Novel isoindole derivatives and salts thereof,processes for producing the same and antitumor agent comprising the same
EP0695755B1 (en) * 1994-08-04 1998-10-21 F. Hoffmann-La Roche AG Pyrrolocarbazole
US7122679B2 (en) * 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof

Also Published As

Publication number Publication date
MXPA04010617A (en) 2004-12-13
BR0309783A (en) 2005-03-22
WO2003091255A1 (en) 2003-11-06
JP2006504632A (en) 2006-02-09
EP1501831A1 (en) 2005-02-02
CA2483496A1 (en) 2003-11-06

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase