AU2002359781A1 - Triple transgenic mouse model of alzheimer's disease - Google Patents
Triple transgenic mouse model of alzheimer's diseaseInfo
- Publication number
- AU2002359781A1 AU2002359781A1 AU2002359781A AU2002359781A AU2002359781A1 AU 2002359781 A1 AU2002359781 A1 AU 2002359781A1 AU 2002359781 A AU2002359781 A AU 2002359781A AU 2002359781 A AU2002359781 A AU 2002359781A AU 2002359781 A1 AU2002359781 A1 AU 2002359781A1
- Authority
- AU
- Australia
- Prior art keywords
- alzheimer
- disease
- mouse model
- transgenic mouse
- triple transgenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 238000011823 triple-transgenic mouse model Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34338301P | 2001-12-20 | 2001-12-20 | |
US60/343,383 | 2001-12-20 | ||
PCT/US2002/040929 WO2003053136A2 (en) | 2001-12-20 | 2002-12-20 | Triple transgenic mouse model of alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002359781A8 AU2002359781A8 (en) | 2003-07-09 |
AU2002359781A1 true AU2002359781A1 (en) | 2003-07-09 |
Family
ID=23345897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002359781A Abandoned AU2002359781A1 (en) | 2001-12-20 | 2002-12-20 | Triple transgenic mouse model of alzheimer's disease |
Country Status (5)
Country | Link |
---|---|
US (1) | US7479579B2 (en) |
EP (1) | EP1469717A4 (en) |
JP (1) | JP4343695B2 (en) |
AU (1) | AU2002359781A1 (en) |
WO (1) | WO2003053136A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080249058A1 (en) * | 2007-04-05 | 2008-10-09 | Erik Roberson | Agents that reduce neuronal overexcitation |
US8933295B2 (en) | 2008-06-20 | 2015-01-13 | Janssen Biotech, Inc. | Identifying agents to treat alzheimer's disease-related decreased sorting behavior by administration to a triple transgenic mouse expressing mutant forms of APP, presenilin or tau |
ES2335848B1 (en) * | 2008-10-02 | 2011-02-02 | Universidade De Santiago De Compostela | IN VITRO CELLULAR COMPOSITION WITH SIMULTANEOUS EXPRESSION OF MUTED HUMAN GENES PS1 M146V, APP SWE AND TAU P301L. |
ES2357284B8 (en) | 2009-09-30 | 2012-03-20 | Universidade De Santiago De Compostela | USE OF GYMNODIMINE, ANALOGS AND DERIVATIVES FOR THE TREATMENT AND / OR PREVENTION OF NEURODEGENERATIVE DISEASES RELATED TO TAU AND BETA-AMYLOID |
ES2357934B2 (en) | 2009-10-19 | 2011-09-08 | Universidad De Santiago De Compostela | USE OF AN ESPIROLIDO ANALOGS AND DERIVATIVES FOR THE TREATMENT AND / OR PREVENTION OF PATHOLOGIES RELATED TO TAU AND B-AMYLOID PROTEINS. |
ES2363975B8 (en) | 2010-02-08 | 2012-10-03 | Universidade De Santiago De Compostela | USE OF YESOTOXINE. ANALOGS AND DERIVATIVES FOR THE TREATMENT AND / OR PREVENTION OF NEURODEGENERATIVE DISEASES RELATED TO TAU AND BETA-AMILOID. |
WO2012103218A1 (en) * | 2011-01-25 | 2012-08-02 | University Of South Florida | A transgenic model of alzheimer's disease |
KR101791296B1 (en) * | 2014-04-17 | 2017-10-27 | 제주대학교 산학협력단 | Expression cassette and vector with genes related Alzheimer's disease and transgenic cell line made from it |
KR101890978B1 (en) | 2014-06-17 | 2018-08-24 | 서울대학교산학협력단 | Transgenic cloned porcine Models for alzheimer's disease and the Use thereof |
WO2016086197A1 (en) | 2014-11-25 | 2016-06-02 | The Brigham And Women's Hospital, Inc. | Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease |
WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
JP6980674B2 (en) * | 2016-02-29 | 2021-12-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Rodents with the humanized TMPRSS gene |
KR101938956B1 (en) * | 2016-05-31 | 2019-01-15 | 제주대학교 산학협력단 | Neuronal-specific expression porcine thy1 gene promotor |
KR101876423B1 (en) * | 2016-10-10 | 2018-07-09 | 한국과학기술연구원 | Dementia Model Transgenic Mouse and Screening Method using thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5814318A (en) * | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5550316A (en) * | 1991-01-02 | 1996-08-27 | Fox Chase Cancer Center | Transgenic animal model system for human cutaneous melanoma |
WO1995011968A1 (en) * | 1993-10-27 | 1995-05-04 | Athena Neurosciences, Inc. | Transgenic animals harboring app allele having swedish mutation |
US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
CA2182311A1 (en) * | 1994-01-27 | 1995-08-03 | Karen Hsiao | Transgenic non-human mammals with progressive neurologic disease |
US5986054A (en) * | 1995-04-28 | 1999-11-16 | The Hospital For Sick Children, Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease |
US5898094A (en) * | 1996-10-21 | 1999-04-27 | University Of South Florida | Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes |
US6255555B1 (en) * | 1997-04-17 | 2001-07-03 | Japan Science And Technology Corporation | Transgenic mouse expressing human fusin and human CD4 |
IL136626A0 (en) * | 1997-12-19 | 2001-06-14 | American Home Prod | Transgenic animal model for degenerative diseases of cartilage |
EP1077990A1 (en) * | 1998-05-01 | 2001-02-28 | Mayo Foundation For Medical Education And Research | Pathogeniv tau mutations |
US6664443B1 (en) * | 1998-05-01 | 2003-12-16 | Mayo Foundation For Medical Education And Research | Pathogenic Tau mutations in transgenic mice |
-
2002
- 2002-12-20 EP EP02794343A patent/EP1469717A4/en not_active Withdrawn
- 2002-12-20 JP JP2003553906A patent/JP4343695B2/en not_active Expired - Lifetime
- 2002-12-20 US US10/499,269 patent/US7479579B2/en not_active Expired - Lifetime
- 2002-12-20 AU AU2002359781A patent/AU2002359781A1/en not_active Abandoned
- 2002-12-20 WO PCT/US2002/040929 patent/WO2003053136A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1469717A4 (en) | 2007-08-22 |
AU2002359781A8 (en) | 2003-07-09 |
JP2005512550A (en) | 2005-05-12 |
WO2003053136A2 (en) | 2003-07-03 |
WO2003053136A3 (en) | 2004-02-19 |
US7479579B2 (en) | 2009-01-20 |
US20050022256A1 (en) | 2005-01-27 |
JP4343695B2 (en) | 2009-10-14 |
EP1469717A2 (en) | 2004-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |