AU2002231325A1 - Stat modulators - Google Patents

Stat modulators

Info

Publication number
AU2002231325A1
AU2002231325A1 AU2002231325A AU3132502A AU2002231325A1 AU 2002231325 A1 AU2002231325 A1 AU 2002231325A1 AU 2002231325 A AU2002231325 A AU 2002231325A AU 3132502 A AU3132502 A AU 3132502A AU 2002231325 A1 AU2002231325 A1 AU 2002231325A1
Authority
AU
Australia
Prior art keywords
stat
modulators
stat modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002231325A
Inventor
Alan Huang
Jiwen Liu
Julio Medina
Xuemei Wang
Feng Xu
Liusheng Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tularik Inc
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Publication of AU2002231325A1 publication Critical patent/AU2002231325A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2002231325A 2000-11-08 2001-11-08 Stat modulators Abandoned AU2002231325A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24687600P 2000-11-08 2000-11-08
US60/246,876 2000-11-08
PCT/US2001/050760 WO2002038107A2 (en) 2000-11-08 2001-11-08 Stat modulators

Publications (1)

Publication Number Publication Date
AU2002231325A1 true AU2002231325A1 (en) 2002-05-21

Family

ID=22932613

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002231325A Abandoned AU2002231325A1 (en) 2000-11-08 2001-11-08 Stat modulators

Country Status (3)

Country Link
US (2) US6884782B2 (en)
AU (1) AU2002231325A1 (en)
WO (1) WO2002038107A2 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US6995115B2 (en) * 2003-09-23 2006-02-07 Catalytic Materials, Llc Catalyst for the generation of CO-free hydrogen from methane
EP1730148A4 (en) * 2004-02-03 2009-08-19 Abbott Lab Aminobenzoxazoles as therapeutic agents
WO2006031976A2 (en) 2004-09-14 2006-03-23 Mcgill University Compositions and methods for treating stat-6 associated diseases or conditions
US20100035793A1 (en) * 2005-07-27 2010-02-11 Cheh Peng Lim Modulators
SI2395002T1 (en) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition containing a heterocyclic modulator of atp-binding cassette transporters.
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
JP2010510227A (en) 2006-11-20 2010-04-02 プレジデント アンド フェロウズ オブ ハーバード カレッジ Pain and itching treatment methods, compositions and kits
JP5497633B2 (en) 2007-05-09 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド CFTR modulator
SI2225230T1 (en) 2007-12-07 2017-03-31 Vertex Pharmaceuticals Incorporated Solid forms of 3-(6-(1-(2,2-difluorobenzo(d)(1,3)dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
PL2639223T3 (en) 2007-12-07 2017-09-29 Vertex Pharmaceuticals Incorporated Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
CA2931134C (en) 2008-02-28 2019-07-30 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
US20100240624A1 (en) * 2009-03-17 2010-09-23 Aciex Therapeutics, Inc. Ophthalmic Formulations of Ketotifen and Methods of Use
US20120172429A1 (en) 2009-07-10 2012-07-05 Woolf Clifford J Permanently charged sodium and calcium channel blockers as anti- inflammatory agents
JP2013523833A (en) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド 3- (6- (1- (2,2-difluorobenzo [D] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid pharmaceutical composition and Its administration
CN102267964B (en) * 2011-06-15 2014-06-18 浙江师范大学 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof
US10130632B2 (en) 2012-11-27 2018-11-20 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
RU2016122882A (en) 2013-11-12 2017-12-19 Вертекс Фармасьютикалз Инкорпорейтед METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CFTR MEDIATED DISEASES
SG11201606080SA (en) 2014-02-03 2016-08-30 Vitae Pharmaceuticals Inc Dihydropyrrolopyridine inhibitors of ror-gamma
PT3207043T (en) 2014-10-14 2019-03-25 Vitae Pharmaceuticals Llc Dihydropyrrolopyridine inhibitors of ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
RU2691136C2 (en) 2014-11-18 2019-06-11 Вертекс Фармасьютикалз Инкорпорейтед High-performance test high-performance liquid chromatography method
RU2018107695A (en) 2015-08-03 2019-09-05 Президент Энд Феллоуз Оф Гарвард Колледж CHARGED ION CHANNEL BLOCKERS AND METHODS OF APPLICATION
ES2856931T3 (en) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc ROR-gamma modulators
EP3377482B1 (en) 2015-11-20 2021-05-12 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI757266B (en) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 Modulators of ror-gamma
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
AR112461A1 (en) 2017-07-24 2019-10-30 Vitae Pharmaceuticals Inc PROCESSES FOR THE PRODUCTION OF SALTS AND CRYSTAL FORMS OF RORg INHIBITORS
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of ror gamma
SG11202109720WA (en) 2019-03-11 2021-10-28 Nocion Therapeutics Inc Charged ion channel blockers and methods for use
KR20210145164A (en) 2019-03-11 2021-12-01 녹시온 테라퓨틱스 인코포레이티드 Ester Substituted Ion Channel Blockers and Methods of Use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2020237474A1 (en) 2019-03-11 2021-09-30 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021091586A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10842798B1 (en) 2019-11-06 2020-11-24 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2021236130A1 (en) 2020-03-11 2022-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2024064080A1 (en) * 2022-09-19 2024-03-28 Kymera Therapeutics, Inc. Stat6 degraders and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463023A (en) * 1993-10-22 1995-10-31 Washington University Composition for inhibition of intracellular transcription
US5638858A (en) * 1994-02-28 1997-06-17 Gettinger; Wayne A. Gas cylinder safety cover
US5591825A (en) * 1994-07-05 1997-01-07 Tularik, Inc. Interleukin 4 signal transducers
NZ270287A (en) * 1995-01-05 1998-06-26 Jason Robert Jones Sanding aid comprises a handle portion with attached pad and abrasive sheet is releasably attached to the pad
US5716622A (en) * 1995-01-06 1998-02-10 The Rockefeller University Functionally active regions of signal transducer and activators of transcription
EP0726296B1 (en) * 1995-02-10 2001-08-16 Ciba SC Holding AG Azo dyestuffs
US5618693A (en) * 1995-02-23 1997-04-08 Tularik, Inc. Interleukin-2 signal transducers and binding assays
US5639858A (en) * 1995-03-22 1997-06-17 Tularik, Inc. Human signal transducer and binding assays
DE19527575A1 (en) 1995-07-28 1997-01-30 Basf Ag Process for the preparation of peptide active ingredients
US5718822A (en) * 1995-09-27 1998-02-17 The Metraflex Company Differential pressure apparatus for detecting accumulation of particulates in a filter
GB9700597D0 (en) 1997-01-14 1997-03-05 Sandoz Pharma Uk Organic compounds
US6261399B1 (en) * 1997-02-26 2001-07-17 The Goodyear Tire & Rubber Company Pneumatic tires and method of making
US5791155A (en) * 1997-06-06 1998-08-11 Carrier Corporation System for monitoring expansion valve
AU1457299A (en) 1997-11-12 1999-05-31 Ariad Pharmaceuticals, Inc. Novel signal transduction inhibitors, compositions containing them
US6207391B1 (en) * 1998-03-31 2001-03-27 Tularik Inc. High-throughput screening assays for modulators of STAT4 and STAT6 activity
US6426331B1 (en) * 1998-07-08 2002-07-30 Tularik Inc. Inhibitors of STAT function
JP2002529444A (en) 1998-11-12 2002-09-10 アリアド・ファーマシューティカルズ・インコーポレイテッド Bicyclic signaling inhibitors, compositions containing them and uses thereof
JP2000229959A (en) * 1999-02-04 2000-08-22 Sumitomo Pharmaceut Co Ltd Stat6 activation inhibitor
WO2001083517A1 (en) 2000-05-03 2001-11-08 Tularik Inc. Stat4 and stat6 binding dipeptide derivatives

Also Published As

Publication number Publication date
US20050101540A1 (en) 2005-05-12
WO2002038107A2 (en) 2002-05-16
US20020151504A1 (en) 2002-10-17
US6884782B2 (en) 2005-04-26
WO2002038107A3 (en) 2002-07-25

Similar Documents

Publication Publication Date Title
AU2002231325A1 (en) Stat modulators
AU2001252612A1 (en) Ppargamma modulators
AU2001264879A1 (en) Electrochromic devices
AU2001288623A1 (en) Fxr modulators
AU2001262847A1 (en) Language-understanding
AU2001292739A1 (en) 1-oxorapamycins
AU2000267458A1 (en) Hypercomputer
AU2001254546A1 (en) Aminopiperidines
AU2001286965A1 (en) Sodium channel modulators
AUPQ998100A0 (en) Application development
AU2001239310A1 (en) Decahydro-isoquinolines
AU2001220246A1 (en) Neckphone
AU2001258349A1 (en) Bisacylguanidine
AU2001296577A1 (en) Chlorophyllases
AU2001279754A1 (en) Indoloquinazolinones
AU2001285886A1 (en) 2-guanidino-4-aryl-quinazoline
AU2002211128A1 (en) Step-bike
AU2001290931A1 (en) Ski-snowboard
AU2001293852A1 (en) Sulfonylguanidine
AU2001258924A1 (en) Microsatellite-aflp
AU2002215110A1 (en) Nonlinear systems
AU2001291876A1 (en) Triazolo-epothilones
AU2001246864A1 (en) Hypotensors
EP1368891B8 (en) Iq modulator
AU4620300A (en) Can