AU2002221753A1 - Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same - Google Patents

Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Info

Publication number
AU2002221753A1
AU2002221753A1 AU2002221753A AU2002221753A AU2002221753A1 AU 2002221753 A1 AU2002221753 A1 AU 2002221753A1 AU 2002221753 A AU2002221753 A AU 2002221753A AU 2002221753 A AU2002221753 A AU 2002221753A AU 2002221753 A1 AU2002221753 A1 AU 2002221753A1
Authority
AU
Australia
Prior art keywords
azaindoles
phosphodiesterase
inhibitors
novel
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2002221753A
Other versions
AU2002221753B2 (en
Inventor
Ute Egerland
Norbert Hofgen
Thomas Kronbach
Hildegard Kuss
Degenhard Marx
Emmanuel Polymeropoulos
Stefan Szelenyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotie Therapies GmbH
Original Assignee
Biotie Therapies GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10053275A external-priority patent/DE10053275A1/en
Application filed by Biotie Therapies GmbH filed Critical Biotie Therapies GmbH
Priority claimed from PCT/EP2001/012376 external-priority patent/WO2002034747A1/en
Publication of AU2002221753A1 publication Critical patent/AU2002221753A1/en
Application granted granted Critical
Publication of AU2002221753B2 publication Critical patent/AU2002221753B2/en
Assigned to BIOTIE THERAPIES GMBH reassignment BIOTIE THERAPIES GMBH Request to Amend Deed and Register Assignors: ELBION AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

AU2002221753A 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same Ceased AU2002221753B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10053275.6 2000-10-27
DE10053275A DE10053275A1 (en) 2000-10-27 2000-10-27 New 7-aza-indole-3-carboxamides or glyoxylamides, useful e.g. for treating rheumatoid arthritis, osteoporosis, sepsis, asthma or multiple sclerosis are phosphodiesterase-4 and tumor necrosis factor-alpha inhibitors
US24434200P 2000-10-30 2000-10-30
US60/244,342 2000-10-30
PCT/EP2001/012376 WO2002034747A1 (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Publications (2)

Publication Number Publication Date
AU2002221753A1 true AU2002221753A1 (en) 2002-07-11
AU2002221753B2 AU2002221753B2 (en) 2006-12-14

Family

ID=26007507

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002221753A Ceased AU2002221753B2 (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
AU2175302A Pending AU2175302A (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method forproducing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2175302A Pending AU2175302A (en) 2000-10-27 2001-10-25 Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method forproducing the same

Country Status (28)

Country Link
US (3) US7169787B2 (en)
EP (1) EP1330455B1 (en)
JP (1) JP4233322B2 (en)
KR (2) KR100837099B1 (en)
CN (1) CN1247576C (en)
AR (1) AR034269A1 (en)
AT (1) ATE301121T1 (en)
AU (2) AU2002221753B2 (en)
BG (1) BG66169B1 (en)
BR (1) BR0114903A (en)
CA (1) CA2428468C (en)
CZ (1) CZ20031146A3 (en)
DE (1) DE50106993D1 (en)
DK (1) DK1330455T3 (en)
EE (1) EE05271B1 (en)
ES (1) ES2246349T3 (en)
HK (1) HK1053839A1 (en)
HR (1) HRP20030427B1 (en)
HU (1) HUP0303034A3 (en)
IL (2) IL155386A0 (en)
MX (1) MXPA03003624A (en)
NO (1) NO324947B1 (en)
NZ (1) NZ525369A (en)
PL (1) PL213999B1 (en)
PT (1) PT1330455E (en)
SK (1) SK287774B6 (en)
TW (1) TWI262920B (en)
WO (1) WO2002034747A1 (en)

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US20040014761A1 (en) * 1997-10-28 2004-01-22 Place Virgil A. Treatment of female sexual dysfunction with phosphodiesterase inhibitors
NZ564480A (en) * 2002-11-06 2008-12-24 Celgene Corp Use of selective cytokine inhibitory drugs for the treatment of Behcet's disease
DE10318610A1 (en) * 2003-04-24 2004-11-11 Elbion Ag 7-azaindoles and their use as therapeutic agents
US20050054691A1 (en) * 2003-08-29 2005-03-10 St. Jude Children's Research Hospital Carboxylesterase inhibitors
AU2004270733B2 (en) * 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
JP2008503446A (en) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド PDE4B inhibitor and use thereof
MY144903A (en) 2004-06-17 2011-11-30 Novartis Ag Pyrrolopyridine derivatives and their use as crth2 antagonists
US7605168B2 (en) * 2004-09-03 2009-10-20 Plexxikon, Inc. PDE4B inhibitors
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
GB0525143D0 (en) 2005-12-09 2006-01-18 Novartis Ag Organic compounds
MX2008014450A (en) 2006-05-18 2009-03-09 Mannkind Corp Intracellular kinase inhibitors.
CA2661850A1 (en) 2006-09-01 2008-03-06 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
US8012992B2 (en) 2008-06-30 2011-09-06 Allergan, Inc. Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2010033981A2 (en) * 2008-09-22 2010-03-25 Isis Innovation Ltd. 5-azaindole bisphosphonates
WO2011023696A1 (en) * 2009-08-26 2011-03-03 Nycomed Gmbh Methylpyrrolopyridinecarboxamides
WO2012072727A1 (en) * 2010-12-03 2012-06-07 Biotie Therapies Gmbh Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4
WO2012080329A1 (en) * 2010-12-17 2012-06-21 Biotie Therapies Gmbh Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide
CN102584842A (en) * 2011-01-17 2012-07-18 北京大学 Preparation of substituted indole lactam derivative and application of substituted indole lactam derivative as antimalarial agent
CN104736202B (en) 2012-08-22 2021-09-07 康奈尔大学 Methods for inhibiting fascin
JP6691869B2 (en) * 2014-02-20 2020-05-13 コーネル ユニヴァーシティー Compounds and methods for inhibiting fascin
WO2020077174A1 (en) 2018-10-12 2020-04-16 Board Of Regents Of The University Of Nebraska Phosphodiesterase inhibitors

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GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
WO1991009598A1 (en) 1990-01-05 1991-07-11 Pfizer Inc. Azaoxindole derivatives
US5023265A (en) 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
US5811432A (en) 1990-11-09 1998-09-22 Pfizer Inc Azaoxindole derivatives
CA2140441C (en) 1992-07-28 2006-11-21 Garry Fenton Inhibitors of c-amp phosphodiesterase and tnf
RU2155187C2 (en) 1992-08-06 2000-08-27 Варнер-Ламберт Компани Derivatives of indole, their tautomers, mixtures of their isomers or separate isomers and pharmaceutically acceptable salts, pharmaceutical composition showing antitumor or inhibiting protein tyrosine kinase activity and method of inhibition of protein tyrosine kinase-depending disease or control of aberrant growth of mammalian or human cells
JP3119758B2 (en) * 1993-02-24 2000-12-25 日清製粉株式会社 7-Azaindole derivative and antiulcer drug containing the same as active ingredient
DK0758233T3 (en) 1994-04-21 2004-03-22 Schering Ag PDE IV inhibitors for the treatment of multiple sclerosis
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9507297D0 (en) 1995-04-07 1995-05-31 Rh Ne Poulenc Rorer Limited New composition of matter
JPH09169665A (en) 1995-12-21 1997-06-30 Kenichi Miyamoto Agent for treatment osteoporosis
JP3601898B2 (en) 1996-02-14 2004-12-15 俊隆 鍋島 Drug-dependent formation inhibitor
AUPO282996A0 (en) * 1996-10-07 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Novel compounds
JP2002539124A (en) * 1999-03-10 2002-11-19 メルク エンド カムパニー インコーポレーテッド 6-azaindole compounds as gonadotropin-releasing hormone antagonists

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