AU2002221596A1 - Adsorbent having differently modified surface areas, method for the production thereof and use of the same - Google Patents

Adsorbent having differently modified surface areas, method for the production thereof and use of the same

Info

Publication number
AU2002221596A1
AU2002221596A1 AU2002221596A AU2159602A AU2002221596A1 AU 2002221596 A1 AU2002221596 A1 AU 2002221596A1 AU 2002221596 A AU2002221596 A AU 2002221596A AU 2159602 A AU2159602 A AU 2159602A AU 2002221596 A1 AU2002221596 A1 AU 2002221596A1
Authority
AU
Australia
Prior art keywords
adsorbent
carrier material
porous carrier
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002221596A
Inventor
Hanno Baumann
Franz-Josef Gerner
Michael Hoffmann
Roland Horres
Andreas Kokott
Hans-Peter Leinenbach
Gunter Mathar
Wolfgang Metzger
Veit Otto
Walter Ruger
Martin Schimmel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Hemocare GmbH
Original Assignee
Fresenius Hemocare GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Hemocare GmbH filed Critical Fresenius Hemocare GmbH
Publication of AU2002221596A1 publication Critical patent/AU2002221596A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/327—Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/328—Polymers on the carrier being further modified
    • B01J20/3282—Crosslinked polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Polymerisation Methods In General (AREA)

Abstract

An adsorbent for whole blood in the form of essentially spherical non-aggregated particles. The adsorbent comprises a porous carrier material having an average pore size of ≰1.5 μm, whereby a maximum of 50% of the pore volume may be in pores having a pore size of >1.5 μm, whereby the outer surfaces of the porous carrier material have at least one surface modification M1 so that the outer surface essentially does not interact with blood cells, and the inner surfaces of the porous carrier material, e.g., the surfaces of the pores of the porous carrier material, have at least one surface modification M2 which interacts with substances present in blood.
AU2002221596A 2000-09-14 2001-09-14 Adsorbent having differently modified surface areas, method for the production thereof and use of the same Abandoned AU2002221596A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10045434.8 2000-09-14
DE10045434A DE10045434B4 (en) 2000-09-14 2000-09-14 Adsorbent with differently modified surface areas, process for its preparation and use thereof
PCT/EP2001/010678 WO2002022253A2 (en) 2000-09-14 2001-09-14 Adsorbent having differently modified surface areas, method for the production thereof and use of the same

Publications (1)

Publication Number Publication Date
AU2002221596A1 true AU2002221596A1 (en) 2002-03-26

Family

ID=7656160

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002221596A Abandoned AU2002221596A1 (en) 2000-09-14 2001-09-14 Adsorbent having differently modified surface areas, method for the production thereof and use of the same

Country Status (8)

Country Link
US (1) US7838306B2 (en)
EP (1) EP1326708B1 (en)
JP (1) JP2004508188A (en)
AT (1) ATE332188T1 (en)
AU (1) AU2002221596A1 (en)
DE (2) DE10045434B4 (en)
ES (1) ES2267838T3 (en)
WO (1) WO2002022253A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291080A3 (en) * 2001-09-10 2004-05-19 Tosoh Corporation Process for production of partially hydrophilized porous adsorbents
DE10147463B4 (en) * 2001-09-20 2009-03-19 Hemoteq Ag Process for the preparation of an absorber, absorber and its use
DE10325304B3 (en) * 2003-06-04 2005-03-24 Fresenius Hemocare Adsorber Technology Gmbh Adsorbent for lowering the concentration of fibrinogen and / or fibrin in blood or blood plasma, process for its preparation and its use
WO2007069983A1 (en) 2005-12-13 2007-06-21 Exthera Ab Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
WO2008157570A2 (en) * 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood
US8758286B2 (en) 2009-12-01 2014-06-24 Exthera Medical Corporation Method for removing cytokines from blood with surface immobilized polysaccharides
AT509192B1 (en) * 2010-06-24 2011-07-15 Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems SORPTION FOR ENDOTOXINES
CA2823772C (en) 2011-01-06 2019-03-12 Cytosorbents Corporation Compositions and methods useful in selectively modifying the internal and external surfaces of porous polymer beads
US8192924B1 (en) 2011-04-21 2012-06-05 Tcp Reliable, Inc. Rapid cooling to and maintaining of whole blood at 20 to 24C for processing
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
JP6223347B2 (en) * 2011-11-01 2017-11-01 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Protein chromatography matrix with hydrophilic copolymer coating
ES2647577T3 (en) 2012-06-13 2017-12-22 Exthera Medical Corporation Use of heparin and carbohydrates to treat cancer
CN110772677A (en) 2013-06-24 2020-02-11 艾克塞拉医疗公司 Blood filtration system comprising mannose coated substrate
WO2015069942A1 (en) 2013-11-08 2015-05-14 Exthera Medical Corporation Methods for diagnosing infectious diseases using adsorption media
JP2017513636A (en) 2014-04-24 2017-06-01 エクスセラ メディカル コーポレイション Method for removing bacteria from blood using high flow rate
JP7100454B2 (en) 2014-09-22 2022-07-13 エクスセラ メディカル コーポレイション Wearable blood perfusion device
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
JP6862679B2 (en) * 2016-05-13 2021-04-21 昭和電工マテリアルズ株式会社 Method for producing porous polymer particles
CN112867550A (en) * 2018-10-19 2021-05-28 克劳斯·戈特沙尔 Filter media, materials and methods for removing contaminants

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US3770631A (en) * 1971-06-29 1973-11-06 Baxter Laboratories Inc Clarification of blood serum and plasma
SE457797B (en) * 1982-01-13 1989-01-30 Kureha Chemical Ind Co Ltd PROCEDURES FOR PREPARING POROEST SUBSTRATE INCLUDING PEARLS THAT HAVE METHYLOL GROUPS OF CO-POLYMS BASED BY THE CIRCUIT BOARD AND APPLICATION OF THE SUBSTRATE BY SCIENCE CHROMATOGRAPHY
FR2534486B1 (en) 1982-10-15 1987-11-20 Commissariat Energie Atomique SURFACE GRAFT PARTICULATE SUPPORT, ITS PREPARATION METHOD AND ADSORBENTS FOR AFFINITY CHROMATOGRAPHY INCORPORATING THIS SUPPORT, AS WELL AS THEIR USE, PARTICULARLY IN BIOLOGY
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Also Published As

Publication number Publication date
DE50110410D1 (en) 2006-08-17
EP1326708B1 (en) 2006-07-05
EP1326708A2 (en) 2003-07-16
JP2004508188A (en) 2004-03-18
WO2002022253A2 (en) 2002-03-21
WO2002022253A3 (en) 2002-10-10
ES2267838T3 (en) 2007-03-16
DE10045434A1 (en) 2002-04-04
US7838306B2 (en) 2010-11-23
DE10045434B4 (en) 2005-07-14
ATE332188T1 (en) 2006-07-15
US20040202783A1 (en) 2004-10-14

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